Gel for nursing rhagadia manus and pedis as well as preparation method and application thereof

Abstract

The invention relates to the technical field of nursing gel preparation, in particular to hand and foot rhagadia nursing gel and a preparation method and application thereof. The traditional Chinese medicine composition is specifically prepared from the following components in parts by mass: 3 to 5 parts of berberine, 3 to 5 parts of triptolide, 2 to 4 parts of dragon's blood extract, 1 to 3 parts of ligusticum wallichii extract, 1 to 3 parts of red halloysite extract, 0.5 to 0.9 part of frankincense extract, 0.4 to 0.8 part of calamine extract, 6 to 10 parts of plant essential oil, 6 to 10 parts of hyaluronic acid, 5 to 9 parts of carbomer and 200 to 300 parts of mineral oil. The nursing gel provided by the invention has an excellent treatment effect on hand and foot rhagades, also has the effects of resisting bacteria, diminishing inflammation, moisturizing skin, relieving allergy, relieving itching and the like, can repair a skin barrier, is mild and non-irritant to skin, and is short in treatment period, good in effect and quick in effect.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of nursing gels, and in particular to a nursing gel for chapped hands and feet, and a preparation method and application thereof. Background Art

[0002] Chapped hands and feet is a disease in which the skin of the hands and feet becomes dry and has linear cracks due to various reasons, often accompanied by pain. In severe cases, it can affect daily life and work. This disease is more common in the elderly and women because they are often stimulated by mechanical or chemical substances, and the cold winter climate reduces the secretion of subcutaneous sweat glands, dries the skin, thickens the skin keratin, loses elasticity, and are prone to chapped skin.

[0003] At present, there are many methods for treating chapped hands and feet at home and abroad. For example, in Western medicine treatment, commonly used drugs include chapped cream, sulfur salicylic acid ointment, etc.; in Chinese medicine treatment, commonly used drugs include badger ointment, wound burning ointment, etc. The most commonly used are external ointments, for example, antibiotic ointments: such as mupirocin ointment, fusidic acid cream, etc., which are suitable for skin cracks accompanied by infection. These drugs can inhibit the growth and reproduction of bacteria and prevent further infection and suppuration of the wound. After the skin cracks, external bacteria can easily invade. The use of antibiotic ointment can form a protective film on the surface of the wound to reduce bacterial invasion, while helping to reduce inflammatory reactions and promote wound healing. Vaseline: Vaseline is a classic skin moisturizer that can form an oil film on the surface of the skin to prevent the loss of skin moisture and moisturize and protect the cracked skin. Whether it is mild skin chapped or more severe chapped skin, vaseline can provide effective protection and reduce the stimulation of external factors to the cracked skin. Urea cream: Urea cream has the effect of moisturizing and softening keratin. Urea cream is a good choice for cracks caused by dry skin. It can increase the moisture content of the skin, soften the cracked skin, and reduce the possibility of further deepening of the cracks. By improving the dryness of the skin, it creates good conditions for the skin to repair itself. Although there are many products for treating chapped hands and feet, it is difficult to achieve satisfactory treatment results in terms of cure rate and recurrence rate.

[0004] Therefore, how to provide a gel preparation that can effectively prevent and treat chapped hands and feet to solve the technical problems of low cure rate and easy recurrence of preparations for treating chapped hands and feet in the prior art is an issue that needs to be urgently solved by those skilled in the art. Summary of the invention

[0005] The purpose of the present invention is to provide a chapped hands and feet care gel and a preparation method and application thereof.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides a chapped hands and feet care gel, comprising the following components in parts by mass: 3-5 parts of berberine, 3-5 parts of triptolide, 2-4 parts of dragon's blood extract, 1-3 parts of chuanxiong extract, 1-3 parts of red ochre extract, 0.5-0.9 parts of frankincense extract, 0.4-0.8 parts of calamine extract, 6-10 parts of plant essential oils, 6-10 parts of hyaluronic acid, 5-9 parts of carbomer and 200-300 parts of mineral oil.

[0008] Preferably, the plant essential oils are chamomile essential oil and lavender essential oil, with a volume ratio of 12-16:5-9;

[0009] Preferably, the mineral oil is white oil, microcrystalline wax or petrolatum.

[0010] Preferably, the molecular weight of the hyaluronic acid is 2000-4000 kDa.

[0011] The present invention also provides a method for preparing the chapped hands and feet care gel, comprising the following steps:

[0012] (1) Carbomer and mineral oil are mixed, and then water is added to obtain material 1;

[0013] (2) mixing the material 1, the plant essential oil and the hyaluronic acid to obtain the material 2;

[0014] (3) The material 2, berberine, triptolide, dragon's blood extract, chuanxiong extract, red ochre extract, frankincense extract, and calamine extract are mixed and homogenized, the pH is adjusted, and sterilization is performed to obtain a hand and foot chapped care gel.

[0015] Preferably, the mass ratio of the carbomer to water in step (1) is 1:20-30.

[0016] Preferably, the homogenization speed in step (3) is 4000-6000 rpm and the time is 3-5 min.

[0017] Preferably, in step (3), the pH is adjusted to 7.6-8.2.

[0018] Preferably, the sterilization temperature in step (3) is 120-125° C. and the time is 15-20 min.

[0019] The present invention also provides the use of the chapped hands and feet care gel or the chapped hands and feet care gel prepared by the preparation method of the chapped hands and feet care gel in preparing chapped hands and feet treatment drugs.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] Among the components added by the present invention, berberine, also known as berberine, is the main active ingredient extracted from the rhizome of Coptis chinensis, a plant of the genus Coptis chinensis of the family Ranunculaceae. It belongs to the isoquinoline alkaloids and has the effects of antibacterial and anti-inflammatory, heat-clearing, dampness-drying and itching-relieving, and blood circulation and blood stasis-removing. Calamine has a certain inhibitory effect on bacteria and fungi, which is beneficial to sterilization and anti-inflammatory, thereby achieving the purpose of treatment. Red ochre can be used externally to treat symptoms such as sores that do not heal, eczema pus infiltration, etc.

[0022] The added dragon's blood can invigorate blood circulation and relieve pain, dissipate blood stasis and stop bleeding, promote tissue regeneration and heal sores. The component can be used to treat wounds that have not healed for a long time, and frankincense can invigorate blood circulation and relieve pain, reduce swelling and promote tissue regeneration. Dragon's blood and frankincense work synergistically, can help dredge qi and blood blockage in meridians, and relieve pain.

[0023] Triptolide has strong anti-inflammatory and immunosuppressive effects, but the irritation of triptolide active compounds, especially triptolide, to skin and mucous membranes limits its development as an external preparation. The present invention adds Chuanxiong, the main active ingredients of Chuanxiong include volatile oil, ligustrazine, ferulic acid, etc., which have the effects of promoting blood circulation and qi, dispelling wind and relieving pain, wherein the ferulic acid contained in Chuanxiong also has the effect of improving the irritation of triptolide to skin and mucous membranes, because the stimulation of triptolide mainly causes the increase of prostaglandins, and Chuanxiong can reduce related indicators such as prostaglandins. In addition, the present invention prepares a gel preparation, and the gel itself has the effect of skin care, further reduces the irritation of triptolide to the skin, and improves the therapeutic effect of nursing gel for chapped hands and feet. Hyaluronic acid can reduce the inflammatory reaction of the affected part, and also helps the skin to absorb the active ingredients. The chamomile essential oil added by the present invention has anti-inflammatory, anti-allergic and soothing effects, and can effectively alleviate skin sensitivity and inflammatory symptoms. Lavender essential oil has antibacterial, anti-inflammatory and sedative effects, which can relieve skin inflammation and promote the regeneration of skin cells.

[0024] The care gel provided by the present invention not only has excellent therapeutic effect on chapped hands and feet, but also has the effects of antibacterial and anti-inflammatory, moisturizing and skin-moisturizing, soothing and relieving itching, etc. It can repair the skin barrier, is mild and non-irritating to the skin, has a short treatment cycle, good effect, and quick effect. DETAILED DESCRIPTION

[0025] The invention provides a chapped hands and feet care gel, comprising the following components in parts by weight: 3-5 parts of berberine, 3-5 parts of triptolide, 2-4 parts of dragon's blood extract, 1-3 parts of chuanxiong extract, 1-3 parts of red ochre extract, 0.5-0.9 parts of frankincense extract, 0.4-0.8 parts of calamine extract, 6-10 parts of plant essential oil, 6-10 parts of hyaluronic acid, 5-9 parts of carbomer and 200-300 parts of mineral oil;

[0026] Preferably, it is prepared by the following components in parts by weight: 4 parts of berberine, 4 parts of triptolide, 3 parts of dragon's blood extract, 2 parts of chuanxiong extract, 2 parts of red ochre extract, 0.6-0.8 parts of frankincense extract, 0.5-0.7 parts of calamine extract, 7-9 parts of plant essential oils, 7-9 parts of hyaluronic acid, 6-8 parts of carbomer and 220-280 parts of mineral oil;

[0027] It is further preferably prepared by the following components in parts by weight: 4 parts of berberine, 4 parts of triptolide, 3 parts of dragon's blood extract, 2 parts of chuanxiong extract, 2 parts of red ochre extract, 0.7 parts of frankincense extract, 0.6 parts of calamine extract, 8 parts of plant essential oil, 8 parts of hyaluronic acid, 7 parts of carbomer and 240-260 parts of mineral oil;

[0028] More preferably, it is prepared from the following components in parts by mass: 4 parts of berberine, 4 parts of triptolide, 3 parts of Sanguisorba officinalis extract, 2 parts of Chuanxiong extract, 2 parts of red ochre extract, 0.7 parts of frankincense extract, 0.6 parts of calamine extract, 8 parts of plant essential oils, 8 parts of hyaluronic acid, 7 parts of carbomer and 250 parts of mineral oil.

[0029] In the present invention, the plant essential oils are chamomile essential oil and lavender essential oil, and the volume ratio is 12-16:5-9; preferably 13-15:6-8; more preferably 14:6-8; more preferably 14:7.

[0030] In the present invention, the mineral oil is white oil, microcrystalline wax or petrolatum; preferably white oil.

[0031] In the present invention, the molecular weight of the hyaluronic acid is 2000-4000 kDa; preferably, the molecular weight of the hyaluronic acid is 2200-3800 kDa; more preferably, the molecular weight of the hyaluronic acid is 2400-3600 kDa; more preferably, the molecular weight of the hyaluronic acid is 2600-3200 kDa.

[0032] The present invention also provides a method for preparing the chapped hands and feet care gel, comprising the following steps:

[0033] (1) Carbomer and mineral oil are mixed, and then water is added to obtain material 1;

[0034] (2) mixing the material 1, the plant essential oil and the hyaluronic acid to obtain the material 2;

[0035] (3) The material 2, berberine, triptolide, Sanguisorba officinalis extract, Chuanxiong extract, Ophiopogon japonicus extract, frankincense extract, and calamine extract are mixed and homogenized, the pH value is adjusted, and sterilization is performed to obtain a hand and foot chapped skin care gel.

[0036] In the present invention, the mass ratio of the carbomer to water in step (1) is 1:20-30; preferably 1:22-28; more preferably 1:24-26; and more preferably 1:25.

[0037] In the present invention, the homogenization speed in step (3) is 4000-6000 rpm, and the time is 3-5 min; preferably, the homogenization speed is 4400-5600 rpm, and the time is 4 min; further preferably, the homogenization speed is 4800-5200 rpm, and the time is 4 min; more preferably, the homogenization speed is 5000 rpm, and the time is 4 min.

[0038] In the present invention, the pH value in step (3) is adjusted to 7.6-8.2; preferably, the pH value is adjusted to 7.7-8.1; more preferably, the pH value is adjusted to 7.8-8.1; and more preferably, the pH value is adjusted to 7.9.

[0039] In the present invention, the sterilization temperature in step (3) is 120-125°C and the time is 15-20 min; preferably, the sterilization temperature is 121-124°C and the time is 16-19 min; further preferably, the sterilization temperature is 121-123°C and the time is 17-18 min; more preferably, the sterilization temperature is 121°C and the time is 18 min.

[0040] The present invention also provides the use of the chapped hands and feet care gel or the chapped hands and feet care gel prepared by the preparation method of the chapped hands and feet care gel in preparing chapped hands and feet treatment drugs.

[0041] In the present invention, berberine was purchased from REVERE Biotechnology Co., Ltd.; triptolide was purchased from Shanghai Chunshi Biotechnology Co., Ltd.; dragon's blood extract was purchased from Changsha Shanghe Biotechnology Co., Ltd.; Chuanxiong extract was purchased from Xi'an Clover Biotechnology Co., Ltd.; red ochre extract was purchased from Nanjing Puyi Biotechnology Co., Ltd.; frankincense extract was purchased from Xi'an Jincuifang Plant Technology Development Co., Ltd.; calamine extract was purchased from Chengdu Pusi Biotechnology Co., Ltd.; chamomile essential oil and lavender essential oil were purchased from Hubei Shiteng Chemical Technology Co., Ltd.

[0042] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0043] Example 1

[0044] A chapped hands and feet care gel is prepared from the following components in parts by mass: 3 parts of berberine, 3 parts of triptolide, 2 parts of dragon's blood extract, 1 part of chuanxiong extract, 1 part of red ochre extract, 0.5 parts of frankincense extract, 0.4 parts of calamine extract, 6 parts of plant essential oils, 6 parts of hyaluronic acid (molecular weight of 2400-3600 kDa), 5 parts of carbomer and 200 parts of microcrystalline wax; the plant essential oils are chamomile essential oil and lavender essential oil, and the volume ratio is 12:5;

[0045] The preparation method of the chapped hands and feet care gel comprises the following steps:

[0046] (1) Carbomer and microcrystalline wax are mixed, and then water is added to obtain material 1; the mass ratio of carbomer to water is 1:20;

[0047] (2) mixing the material 1, the plant essential oil and the hyaluronic acid to obtain the material 2;

[0048] (3) The material 2, berberine, triptolide, Sanguisorba officinalis extract, Chuanxiong extract, Ophiopogon japonicus extract, frankincense extract, and calamine extract were mixed and homogenized at a speed of 4000 rpm for 3 min, the pH was adjusted to 7.6, and sterilized at 120° C. for 15 min to obtain a hand and foot chapped skin care gel.

[0049] Example 2

[0050] A chapped hands and feet care gel is prepared from the following components in parts by mass: 5 parts of berberine, 5 parts of triptolide, 4 parts of dragon's blood extract, 3 parts of chuanxiong extract, 3 parts of red ochre extract, 0.9 parts of frankincense extract, 0.8 parts of calamine extract, 10 parts of plant essential oil, 10 parts of hyaluronic acid (molecular weight of 2200-3800 kDa), 9 parts of carbomer and 300 parts of petrolatum; the plant essential oil is chamomile essential oil and lavender essential oil, and the volume ratio is 16:9;

[0051] The preparation method of the chapped hands and feet care gel comprises the following steps:

[0052] (1) Carbomer and petrolatum are mixed, and then water is added to obtain material 1; the mass ratio of carbomer to water is 1:30;

[0053] (2) mixing the material 1, the plant essential oil and the hyaluronic acid to obtain the material 2;

[0054] (3) The material 2, berberine, triptolide, Sanguisorba officinalis extract, Chuanxiong extract, Ophiopogon japonicus extract, frankincense extract, and calamine extract were mixed and homogenized at a speed of 6000 rpm for 5 min, the pH was adjusted to 8.2, and sterilized at 125° C. for 20 min to obtain a hand and foot chapped skin care gel.

[0055] Example 3

[0056] A chapped hands and feet care gel is prepared from the following components in parts by mass: 4 parts of berberine, 4 parts of triptolide, 3 parts of dragon's blood extract, 2 parts of chuanxiong extract, 2 parts of red ochre extract, 0.7 parts of frankincense extract, 0.6 parts of calamine extract, 8 parts of plant essential oils, 8 parts of hyaluronic acid (molecular weight of 2600-3200 kDa), 7 parts of carbomer and 250 parts of white oil; the plant essential oils are chamomile essential oil and lavender essential oil, and the volume ratio is 2:1;

[0057] The preparation method of the chapped hands and feet care gel comprises the following steps:

[0058] (1) Carbomer and white oil are mixed, and then water is added to obtain material 1; the mass ratio of carbomer to water is 1:25;

[0059] (2) mixing the material 1, the plant essential oil and the hyaluronic acid to obtain the material 2;

[0060] (3) The material 2, berberine, triptolide, Sanguisorba officinalis extract, Chuanxiong extract, Ophiopogon japonicus extract, frankincense extract, and calamine extract were mixed and homogenized at a speed of 5000 rpm for 4 min, the pH was adjusted to 7.9, and sterilized at 121° C. for 18 min to obtain a hand and foot chapped skin care gel.

[0061] Experimental Example 1

[0062] 1. Select rats weighing 180±15g to prepare rat skin cracking model:

[0063] The specific method is:

[0064] The rats were fed adaptively in the laboratory for 7 days before the model was established. The rats had normal drinking water and diet, and the laboratory temperature was 23±3℃. 24 hours before the experiment, the rats' backs were depilated, with an area of ​​about 3.0cm×3.0cm. 0.5mol / L NaOH solution was applied and 18℃ cold wind was added to stimulate the depilated area of ​​the rat skin twice a day, 30 minutes each time, for 7 consecutive days, so that the exposed skin of the rats was wrinkled and cracked, and the rat skin chapped model was obtained. The rats in the blank control group were not treated in any way.

[0065] 2. The rats after the above modeling were divided into groups, with 5 rats in each group, and the rats were treated according to the following groups:

[0066] Among them, the product obtained by the method of Example 3 was used as the experimental group.

[0067] In control group 1, other methods were the same as those in Example 3, except that triptolide was not added.

[0068] Control group 2: other methods were the same as those in Example 3, except that Chuanxiong was not added.

[0069] Control group 3: other methods were the same as those in Example 3, except that berberine and dragon's blood extract were not included.

[0070] Control group 4: other methods are the same as those of Example 3, except that hyaluronic acid is not included.

[0071] The use method of the experimental group and the control group 1 to the control group 4 is: according to 60mg / cm 2 The dose was applied to the skin of rats in the blank control group and the model group, once in the morning and once in the evening, for 7 consecutive days.

[0072] Prior art group: urea ointment was applied and used according to the method described in the instructions.

[0073] 3. Recovery investigation: After the medication was completed, the recovery of skin damage in rats in each test group was observed and scored. The scoring results are shown in Table 1.

[0074] The specific scoring criteria are:

[0075] 0 points: skin lesions completely disappeared;

[0076] 1 point: the skin lesion repair area reaches 1 / 2 to 1;

[0077] 2 points: the skin lesion repair area reaches 1 / 4 to 1 / 2;

[0078] 3 points: The skin lesion repair area is 0 to 1 / 4.

[0079] Table 1 Skin recovery

[0080]

[0081]

[0082] It can be seen from the data recorded in Table 1 that the wound healing speed of the rats in the experimental group is the fastest, followed by the prior art group, which shows that the gel provided by the present invention can effectively promote the healing of chapped skin.

[0083] 4. After the scoring was completed, all rats were killed, and the skin of the experimental part of the back (1×1 cm) was taken. After formalin fixation for 24 hours, paraffin sections were sliced ​​and HE staining was performed to observe the pathological changes of skin tissue under a microscope. The four aspects of epidermal structure, hair follicles, inflammatory cells, and capillary congestion were mainly observed. The above four parts of the observation content were scored, and the scoring criteria are shown in Table 2. The survey results are shown in Tables 3 to 6.

[0084] Table 2 Scoring table

[0085]

[0086] Table 3 Epidermal structure

[0087]

[0088]

[0089] Table 4 Hair follicles

[0090] Group 1 2 3 4 5 Total score Blank control group 0 0 0 0 0 0 Model Group 3 3 3 3 3 15 Experimental Group 1 0 0 1 1 3 Control group 1 1 2 2 2 1 8 Control group 2 2 1 1 1 2 7 Control group 3 2 2 2 2 2 10 Control group 4 1 2 2 1 1 7 Existing Technology Group 1 1 1 1 1 5

[0091] Table 5 Inflammatory cells

[0092] Group 1 2 3 4 5 Total score Blank control group 0 0 0 0 0 0 Model Group 3 3 3 3 2 14 Experimental Group 2 1 1 1 1 6 Control group 1 2 2 2 2 1 9 Control group 2 3 2 3 2 2 12 Control group 3 2 1 2 3 2 10 Control group 4 2 1 2 1 2 8 Existing Technology Group 1 2 0 1 1 5

[0093] Table 6 Capillary congestion

[0094]

[0095]

[0096] From the contents recorded in Tables 3 to 6, it can be seen that the gel provided by the present invention can help the recovery of the rat epidermis, effectively reduce the production of inflammatory cells, and reduce the congestion of capillaries. Its therapeutic effect is significantly better than that of the drugs in the prior art group.

[0097] From the data of the control group, it can be seen that only the complete formula of the present invention can achieve the best therapeutic effect. If some of the components are discarded, the therapeutic effect of the gel will be significantly affected. From the data of the control group 2, it can be seen that if Chuanxiong is not added, the gel will affect the improvement effect of the congestion of inflammatory cells and capillaries, which is caused by the stimulation of triptolide.

[0098] Experimental Example 2

[0099] The gel provided by the present invention is subjected to an adverse reaction test, specifically referring to the relevant requirements of the "Human Skin Patch Test" in the "Technical Specification for Safety of Cosmetics" (2015 edition) for the human skin adverse reaction test.

[0100] The specific experimental method is as follows: the flexed side of the forearm is used as the test site, with an area of ​​3×3cm 2 The test area should be kept dry, and 0.020 mL of the test substance should be evenly applied to the test area twice a day for 7 consecutive days, and the skin reaction should be observed.

[0101] 20 volunteers aged between 20 and 35 were selected for testing and were evenly divided into two groups. One group used the product obtained from the experimental group. The other group used the product obtained from the control group 2. The skin reactions of volunteers in different groups were investigated on the 1st, 3rd, 5th and 7th days. The specific evaluation criteria are shown in Table 7, and the investigation results are shown in Tables 8 to 11.

[0102] Table 7 Evaluation criteria

[0103]

[0104]

[0105] Table 8 Results of the 1st day survey

[0106] Group 0 1 2 3 4 Experimental Group 10 0 0 0 0 Control group 2 10 0 0 0 0

[0107] Table 9 Results of the 3rd survey

[0108] Group 0 1 2 3 4 Experimental Group 10 0 0 0 0 Control group 2 8 2 0 0 0

[0109] Table 10 Results of the 5th day survey

[0110] Group 0 1 2 3 4 Experimental Group 10 0 0 0 0 Control group 2 5 3 2 0 0

[0111] Table 11 Results of the 7th day survey

[0112] Group 0 1 2 3 4 Experimental Group 10 0 0 0 0 Control group 2 2 4 4 0 0

[0113] From the contents recorded in Tables 8 to 11, it can be seen that no adverse reactions occurred in all volunteers of the experimental group during the test, and the test results of the 10 volunteers were all negative, which shows that the gel prepared by the present invention has good safety. However, a small number of volunteers in the control group 2 developed erythema symptoms on the 3rd day, and the number of volunteers with adverse reactions increased on the 5th and 7th days, which shows that the addition of Chuanxiong helps to reduce the adverse reactions of triptolide.

[0114] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A gel for the care of chapped hands and feet, characterized in that: The invention comprises the following components in parts by weight: 3-5 parts of berberine, 3-5 parts of triptolide, 2-4 parts of dragon's blood extract, 1-3 parts of chuanxiong extract, 1-3 parts of red ochre extract, 0.5-0.9 parts of frankincense extract, 0.4-0.8 parts of calamine extract, 6-10 parts of plant essential oil, 6-10 parts of hyaluronic acid, 5-9 parts of carbomer and 200-300 parts of mineral oil.

2. A chapped hands and feet care gel according to claim 1, characterized in that: The plant essential oils are chamomile essential oil and lavender essential oil, and the volume ratio is 12-16:5-9.

3. The chapped hands and feet care gel according to claim 1, characterized in that: The mineral oil is white oil, microcrystalline wax or petrolatum.

4. The chapped hands and feet care gel according to claim 1, characterized in that: The molecular weight of the hyaluronic acid is 2000-4000 kDa.

5. The method for preparing the chapped hands and feet care gel according to any one of claims 1 to 4, characterized in that: The steps include: (1) Carbomer and mineral oil are mixed, and then water is added to obtain material 1; (2) mixing the material 1, the plant essential oil and the hyaluronic acid to obtain the material 2; (3) The material 2, berberine, triptolide, Sanguisorba officinalis extract, Chuanxiong extract, Ophiopogon japonicus extract, frankincense extract, and calamine extract are mixed and homogenized, the pH value is adjusted, and sterilization is performed to obtain a hand and foot chapped skin care gel.

6. The method for preparing a chapped hands and feet care gel according to claim 5, characterized in that: The mass ratio of the carbomer to water in step (1) is 1:20-30.

7. The method for preparing a chapped hands and feet care gel according to claim 5, characterized in that: The homogenization speed in step (3) is 4000-6000 rpm and the time is 3-5 min.

8. The method for preparing a chapped hands and feet care gel according to claim 5, characterized in that: Step (3) wherein the pH is adjusted to 7.6-8.

2.

9. The method for preparing a chapped hands and feet care gel according to claim 5, characterized in that: The sterilization temperature in step (3) is 120-125° C. and the time is 15-20 minutes.

10. Use of the chapped hands and feet care gel as claimed in any one of claims 1 to 4 or the chapped hands and feet care gel prepared by the preparation method of the chapped hands and feet care gel as claimed in any one of claims 5 to 9 in the preparation of chapped hands and feet treatment drugs.

Images