Tumor electric field treatment system and electric field applying method thereof

Abstract

The invention provides a tumor electric field treatment system which comprises an electric field treatment instrument and at least two pairs of insulated electrodes of the treatment instrument, and the electric field treatment instrument comprises an MCU control unit, a direction control unit, a DC power supply control unit and an AC voltage control unit. The MCU control unit is configured to control the AC voltage control unit to output an alternating electric signal according to system parameters of the electric field therapeutic apparatus. The MCU control unit is further configured to drive the direction control unit to cyclically and alternately apply the alternating electric signals received by the AC voltage control unit to different pairs of insulated electrodes cyclically and alternately based on system parameters of the electric field therapeutic apparatus, so that switching of the alternating electric signals between the different pairs of insulated electrodes is achieved. And the MCU control unit is further configured to control the DC power supply control unit to enable the AC voltage control unit to slowly rise or fall according to a voltage variation set in unit time t when the alternating electric signal is switched between different pairs of insulated electrodes.

Description

[0001] This application is a divisional application of the invention patent application with application date of December 31, 2021, application number 202111667246.0, and invention name “Tumor electric field therapy system and electric field application method thereof”. Technical Field

[0002] The present invention belongs to the technical field of medical devices, and in particular relates to a tumor electric field treatment system and an electric field application method thereof. Background Art

[0003] Chinese invention patent No. CN104771830B discloses a tumor electric field therapy system and an electric field application method thereof. The tumor electric field therapy system includes an electric field therapy device that generates an alternating voltage and two pairs of insulated electrodes electrically connected to the electric field therapy device. The two pairs of insulated electrodes are arranged perpendicular to each other around the malignant tumor site in the experimental animal or the proliferating cells in the tissue culture, and the alternating voltage generated by the electric field therapy device is periodically and alternately applied to the malignant tumor site in the experimental animal or the proliferating cells in the tissue culture to treat the malignant tumor in the experimental animal or inhibit the proliferation of cells in the tissue culture. The electric field therapy device includes an AC signal generator and an AC signal controller electrically connected to the AC signal generator. The AC signal controller generates a periodic control signal with two output states to control the AC signal generator to generate an alternating signal that is applied alternately and at intervals between the two pairs of insulated electrodes. Specifically, when the AC signal controller is in the first output state, the AC signal controller controls the AC signal generator to generate an alternating signal between the first pair of insulated electrodes of the two pairs of insulated electrodes, and does not generate an alternating signal between the second pair of insulated electrodes; when the AC signal controller is in the second output state, the AC signal controller controls the AC signal generator to generate an alternating signal between the second pair of insulated electrodes of the two pairs of insulated electrodes, but does not generate an alternating signal between the first pair of insulated electrodes. That is, when the alternating electrical signal between the first pair of insulated electrodes is turned on, the alternating electrical signal between the second pair of insulated electrodes is turned off; when the alternating electrical signal between the first pair of insulated electrodes is turned off, the alternating electrical signal between the second pair of insulated electrodes is turned on.

[0004] The above-mentioned tumor electric field treatment system realizes the switching of the alternating electric signal generated by the AC signal generator between the two pairs of insulated electrodes by controlling the switching of the AC signal controller between the first output state and the second output state, thereby realizing the alternating electric field of different directions to the proliferating cells of the malignant tumor site of the experimental animal or the tissue culture to treat the tumor or inhibit the proliferating cells. Although the tumor electric field treatment system achieves the purpose of treating tumors or inhibiting the proliferating cells by alternately applying the alternating electric field to the proliferating cells of the malignant tumor site of the experimental animal or the tissue culture through the AC signal controller through two pairs of insulated electrodes, the alternating voltage between the two pairs of insulated electrodes has a voltage mutation at the moment of switching from nothing to something or from something to nothing, and the voltage change per unit time is large, resulting in a signal mutation in the AC signal controller, generating a spike signal, and then impacting and easily damaging the electronic components in the AC signal controller; in addition, when the tumor electric field treatment device is used on the human body, there will also be a problem of tingling on the patient's scalp.

[0005] Therefore, it is necessary to provide an improved tumor electric field treatment system to overcome the defects in the prior art. Summary of the invention

[0006] The invention provides a tumor electric field treatment system which can prevent an alternating voltage from generating a peak signal, impacting or damaging an electronic component when switching.

[0007] The tumor electric field therapy system of the present invention is realized by the following technical scheme: a tumor electric field therapy system, used for applying an alternating electric field to proliferating tumor cells in a tumor site or tissue culture, used for applying an alternating electric field to proliferating tumor cells in a tumor site or tissue culture, comprising an electric field therapy device and at least two pairs of insulated electrodes electrically connected to the electric field therapy device, the electric field therapy device comprising an MCU control unit, a direction control unit connected to the MCU control unit, a DC power supply control unit electrically connected to the MCU control unit, and an AC voltage control unit connected to both the direction control unit and the MCU control unit, the MCU control unit being configured to control the AC voltage control unit to output an alternating electric signal according to system parameters of the electric field therapy device, the MCU control unit being further configured to drive the direction control unit to cycle, alternately cycle, and alternately apply the alternating electric signal received by the AC voltage control unit to non-rotating areas based on the system parameters of the electric field therapy device. On the same pair of insulated electrodes, in order to realize the switching of alternating electric signals between different pairs of insulated electrodes, the system parameters of the electric field therapy device include the output AC voltage amplitude, the preset specific voltage, the preset AC voltage change per unit time and the alternating electric field continuous conduction time t1 of each pair of insulated electrodes in their respective working cycles, and the electric field continuous conduction time t1 includes the initial switching on period t3, the intermediate conduction period and the final switching off period t4; within the switching on period t3, the MCU control unit controls the DC power supply control unit so that the AC voltage value applied by the AC voltage control unit to the insulated electrodes slowly increases from 0 to a specific voltage; the specific voltage is set to be no greater than the peak value of the AC voltage amplitude applied by the electric field therapy device to the insulated electrodes during the conduction period; within the switching off period t4, the MCU control unit controls the DC power supply control unit so that the AC voltage value applied by the AC voltage control unit to the insulated electrodes slowly decreases from the specific voltage to 0.

[0008] Furthermore, a ratio of a voltage variation of the AC voltage control unit per millisecond to the specific voltage is less than 5%.

[0009] Furthermore, it also includes an inverter boost control unit that is simultaneously connected to the MCU control unit and the DC power supply control unit, and a filter control unit connected to the inverter boost control unit. The system parameters of the electric field therapy device include the electric field frequency and the alternating electric signal direction switching period. The MCU control unit generates a pulse signal that is transmitted to the inverter boost control unit based on its reference voltage and the electric field frequency and output AC voltage amplitude of the electric field therapy device.

[0010] Furthermore, the MCU control unit drives the direction control unit to cyclically and alternately switch the alternating electric field applied to different insulated electrode pairs through the AC voltage control unit according to the direction switching cycle of the alternating electric signal of the electric field therapy device.

[0011] Furthermore, the MCU control unit controls the conduction and disconnection between it and the DC power supply control unit and whether to output a pulse signal to the inverter boost control unit according to the direction switching cycle of the alternating electric signal of the electric field therapy device.

[0012] Further, the direction control unit is configured to switch after the MCU control unit disconnects the communication between it and the DC power supply control unit and the MCU control unit stops outputting the pulse signal to the inverter boost control unit.

[0013] Furthermore, the MCU control unit starts the DC power control unit after the direction control unit performs the switching and controls the DC power control unit to output a direct current signal to the inverter boost control unit and simultaneously output a pulse signal to the inverter boost control unit.

[0014] Further, the switching on period t3 is determined by the following method: t3=V / ΔV*t, wherein V is a specific voltage, t is 1 millisecond, and ΔV is a voltage change of the AC voltage control unit per millisecond.

[0015] Furthermore, the alternating electrical signal is increased uniformly from 0 to a specific voltage in a manner of a voltage change of 4V per millisecond during the switching-on time period t3.

[0016] Furthermore, the MCU control unit includes a digital-to-analog conversion module having a DAC data register, and the MCU control unit calculates the voltage output increment of the digital-to-analog conversion module per millisecond based on its reference voltage, the voltage change of the AC voltage control unit per millisecond, the specific voltage, and the DAC data register value corresponding to the specific voltage.

[0017] Furthermore, the MCU control unit calculates the voltage output decrement of the digital-to-analog conversion module per millisecond based on its reference voltage, the voltage change of the AC voltage control unit per millisecond, the specific voltage, and the DAC data register value corresponding to the specific voltage.

[0018] Furthermore, the voltage output increment or decrement of the digital-to-analog conversion module per millisecond is determined by: ΔV DAC = (3.3*1000*△V*DAC) / (4096*V), where △V DAC The voltage output increment or decrement of the digital-to-analog conversion module every millisecond, in millivolts; the MCU reference voltage is 3.3V, and the DAC data register value corresponding to the MCU reference voltage is 4096=2 12 ; △V is the voltage change of the AC voltage control unit per millisecond, in volts; V is the specific voltage, in volts; DAC is the DAC data register value of the specific voltage in the DAC data register.

[0019] Further, the switching disconnection period t4 is obtained by the following method: t4=V / ΔV*t, wherein V is a specific voltage, t is 1 millisecond, and ΔV is a voltage change of the AC voltage control unit per millisecond.

[0020] Furthermore, the alternating electrical signal decreases uniformly from a specific voltage to 0 at a voltage change of 4 V per millisecond during the switching-off time period t4.

[0021] It is to be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a system block diagram of the tumor electric field treatment system of the present invention.

[0023] Figure 2 This is a schematic diagram of the waveform of the control signal generated by the AC signal controller of the electric field therapy device of the tumor electric field therapy system of the present invention.

[0024] Figure 3 Schematic diagram of a preferred waveform applied to the electrodes of the tumor electric field treatment system of the present invention.

[0025] Description of reference numerals:

[0026] Tumor electric field therapy system 1000, electric field therapy device 1, MCU control unit 11, storage module 110, execution module 111, digital-to-analog conversion module 112, DAC data register 1120, control module 113, DC power supply control unit 12, inverter boost control unit 13, boost module 130, inverter module 131, filter control unit 14, AC voltage control unit 15, AC signal generator 10, direction control unit 16, X-direction switch 17, Y-direction switch 18, AC signal controller 20, Y-direction electrode 21, X-direction electrode 22, Y-direction alternating electric field 23, X-direction alternating electric field 24, drive signals 31, 32, insulated electrode 2. DETAILED DESCRIPTION

[0027] Exemplary embodiments will be described in detail herein, examples of which are shown in the accompanying drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present invention. Instead, they are merely examples of devices, systems, equipment, and methods consistent with some aspects of the present invention.

[0028] refer to Figure 1As shown, the tumor electric field treatment system 1000 of the present invention is used to apply an alternating voltage to the proliferating cells in the tumor site or tissue culture to treat the tumor or inhibit the proliferating cells in the tissue culture, and includes an electric field treatment device 1 and two pairs of insulated electrodes 2 electrically connected to the electric field treatment device 1. The electric field treatment device 1 generates an alternating voltage signal for tumor treatment or inhibition of proliferating cells in tissue culture, and applies the generated alternating voltage signal cyclically and alternately between the two pairs of insulated electrodes 2, thereby alternately generating an alternating electric field with a changed direction between the two pairs of insulated electrodes 2. The two pairs of insulated electrodes 2 include a pair of Y-direction electrodes 21 and a pair of X-direction electrodes 22 electrically connected to the electric field treatment device 1. The two Y-direction electrodes 21 are arranged in parallel, and the two X-direction electrodes 22 are arranged in parallel. The two Y-direction electrodes 21 and the two X-direction electrodes 22 are arranged perpendicular to each other. A Y-direction alternating electric field 23 is generated between the two Y-direction electrodes 21. An X-direction alternating electric field 24 is generated between the two X-direction electrodes 22. The X-direction alternating electric field 24 and the Y-direction alternating electric field 23 are arranged perpendicularly.

[0029] The electric field therapy device 1 includes an MCU control unit 11, an inverter boost control unit 13 electrically connected to the MCU control unit 11, a DC power supply control unit 12 which is communicatively connected to the MCU control unit 11 and the inverter boost control unit 13, a filter control unit 14 electrically connected to the inverter boost control unit 13, and an AC voltage control unit 15 electrically connected to the filter control unit 14, a direction control unit 16 electrically connected to the MCU control unit 11, an X-direction switch 17 electrically connected to the direction control unit 16 and controlling the connection and disconnection between the AC voltage control unit 15 and two X-direction electrodes 22, and a Y-direction switch 18 electrically connected to the direction control unit 16 and controlling the connection and disconnection between the AC voltage control unit 15 and two Y-direction electrodes 21.

[0030] The MCU control unit 11 has a reference voltage of 3.3V, and includes a storage module 110, an execution module 111 in communication with the storage module 110, a digital-to-analog conversion module (DAC) 112 in communication with the execution module 111, and a control module 113 that controls the storage module 110, the execution module 111, and the digital-to-analog conversion module 112 to perform corresponding operations. The storage module 110 is configured to store system parameters of the electric field therapy device 1, including electric field frequency, output AC voltage amplitude, alternating electric signal direction switching cycle, etc.

[0031] The execution module 111 is configured to read the electric field frequency, output AC voltage amplitude, and alternating electric signal direction switching cycle of the electric field therapy device 1 from the storage module 110. The execution module 111 is also configured to output a periodic direction switching drive signal to the direction control unit 16 according to the read alternating electric signal direction switching cycle of the electric field therapy device 1. The execution module 111 is also configured to output a pulse signal having the same frequency as the read electric field frequency of the electric field therapy device 1 and the same AC voltage amplitude value as the reference voltage amplitude value of the MCU control unit 11 to the inverter boost control unit 13 according to the read electric field frequency and output AC voltage amplitude of the electric field therapy device 1 and the reference voltage of the MCU control unit 11. In this embodiment, the pulse signal output by the execution module 11 to the inverter boost control unit 13 is a square wave with a frequency of 200KHz, a voltage amplitude of 3.3V, and a duty cycle of 50%.

[0032] The digital-to-analog conversion module 112 is connected to the DC power control unit 12, and has a DAC data register 1120. It can output a corresponding DC voltage to the DC power control unit 12 according to the digital value in the DAC data register 1120 to start the DC power control unit 12. The digital value corresponding to the DAC data register 1120 of the digital-to-analog conversion module 112 and the reference voltage 3.3V of the MCU control unit 11 is 2 12 The control module 113 controls the execution module 111 to execute the above corresponding functions, and the control module 113 also controls the on and off of the communication between the digital-to-analog conversion module 112 and the DC power supply control unit 12 according to the direction switching cycle of the alternating electric signal of the electric field therapy device 1 read by the execution module 111, and controls whether the execution module 111 outputs a pulse signal to the inverter boost control unit 13.

[0033] The DC power supply control unit 12 receives a DC voltage signal of about 500mv outputted from the digital-to-analog conversion module 112 of the MCU control unit 11, and outputs a DC signal of about 20V to the inverter boost control unit 13. The inverter boost control unit 13 has a boost module 130 and an inverter module 131 communicating with the boost module 130. The boost module 130 simultaneously receives a square wave with a frequency of 200KHz, a voltage amplitude of 3.3V, and a duty cycle of 50% outputted from the execution module 111 of the MCU control unit 11 and a DC signal of 20V outputted from the DC power supply control unit 12, and performs a superposition process on the received square wave and the DC signal, and then performs a boost process to output a square wave with a frequency of 200KHz and an AC voltage amplitude of 80V to the inverter module 131. The inverter module 131 receives the square wave signal with a frequency of 200KHz and a voltage amplitude of 80V outputted from the boost module 130, and performs an inversion process on the received square wave signal to output a square wave with a frequency of 200KHz and a voltage amplitude of ±80V to the filter control unit 14. The filter control unit 14 performs a filtering process on the square wave with a frequency of 200KHz and a voltage amplitude of ±80V received from the inverter module 131 to obtain a sine wave with a frequency of 200KHz and an AC voltage peak of 160V, and outputs the filtered sine wave with a frequency of 200KHz and an AC voltage peak of 160V to the AC voltage control unit 15. The AC voltage control unit 15 is connected to the X-direction switch 17 and the Y-direction switch 18 at the same time, and selectively applies the sine wave with a frequency of 200KHz and an AC voltage peak of 160V processed by the filter control unit 14 to the two X-direction electrodes 22 or the two Y-direction electrodes 21 electrically connected to the AC voltage control unit 15 according to the on or off of the X-direction switch 17 and the Y-direction switch 18, so as to generate an X-direction alternating electric field 24 between the two X-direction electrodes 22 or a Y-direction alternating electric field 23 between the two Y-direction electrodes 21 to treat the tumor site or inhibit the proliferation of cells in tissue culture.

[0034] The direction control unit 16 cyclically controls the on and off of the X-direction switch 17 and the Y-direction switch 18 according to the periodic direction switching driving signal output by the execution module 111 of the MCU control unit 11. Specifically, the control module 113 of the MCU control unit 11 controls the execution module 111 to output the periodic direction switching driving signal to the direction control unit 16 according to the direction switching cycle of the alternating electric signal of the electric field therapy device 1 read by the execution module 111, and then the direction control unit 16 alternately and cyclically turns on the X-direction switch 17 and turns off the Y-direction switch 18 or turns off the X-direction switch 17 and turns on the Y-direction switch 18, so as to realize that the sine wave with a frequency of 200KHz and an AC voltage peak of 160V received by the AC voltage control unit 15 is periodically and alternately applied to the two X-direction electrodes 22 and the two Y-direction electrodes 21 electrically connected to the AC voltage control unit 15, so as to periodically and alternately apply the X-direction alternating electric field 24 and the Y-direction alternating electric field 23 to the proliferating cells of the tumor site or tissue culture.

[0035] That is, when the MCU control unit 11 controls the direction control unit 16 to turn on the X-direction switch 17 and turn off the Y-direction switch 18, the AC voltage control unit 15 applies a sine wave signal with a frequency of 200KHz and an AC voltage peak of 160V to the two X-direction electrodes 22 electrically connected thereto, and generates an X-direction alternating electric field 24 between the two X-direction electrodes 22; when the MCU control unit 11 controls the direction control unit 16 to turn off the X-direction switch 17 and turn on the Y-direction switch 18, the AC voltage control unit 15 applies a sine wave signal with a frequency of 200KHz and an AC voltage peak of 160V to the two Y-direction electrodes 21 electrically connected thereto, and generates a Y-direction alternating electric field 23 between the two Y-direction electrodes 21. In this embodiment, the duty cycle of the periodic direction switching drive signal output by the execution module 111 of the MCU control unit 11 to the direction control unit 16 is 50%, and the period is 2 seconds. That is, the direction control unit 16 controls the X-direction switch 17 to be turned on at the first second, the Y-direction switch 18 to be turned on at the second second, the X-direction switch 17 to be turned on at the third second, and the Y-direction switch 18 to be turned on at the fourth second, and so on. The tumor electric field treatment system 1000 applies an alternating voltage to the X-direction electrode 22 and the Y-direction electrode 21 cyclically by cyclically turning on the X-direction switch 17 and the Y-direction switch 18 to treat the tumor site or inhibit the proliferation of cells in tissue culture.

[0036] Figure 2It is a waveform diagram of a driving signal for controlling the periodic direction switching of the electric field direction switching applied between the Y-direction electrode 21 and the X-direction electrode 22, that is, a waveform diagram of the driving signal of the direction control unit 16 to the X-direction switch 17 and the Y-direction switch 18. The driving signal 31 and the driving signal 32 correspond to the X-direction electrode 22 and the Y-direction electrode 21, respectively. The duty ratios of the driving signals 31 and 32 are both 50%, and the periods are both 2 seconds. The X-direction switch 17 and the Y-direction switch 18 are switched on and off alternately, and each switch is switched on and off for 1 second each time, and at the same time point, only one of the X-direction switch 17 and the Y-direction switch 18 is switched on, that is, when the X-direction switch 17 is switched on, the X-direction electrode 22 generates an X-direction AC electric field, after the X-direction switch 17 is switched on for 1 second, the X-direction switch 17 is switched off, the Y-direction switch 18 is switched on, and the Y-direction electrode 21 generates a Y-direction AC electric field, after the Y-direction switch 18 is switched on for 1 second, the Y-direction switch 18 is switched off, and the X-direction switch 17 is switched on again, and the cycle repeats. The direction control unit 16 switches the X-direction switch 17 and the Y-direction switch 18 so that the target area is alternately subjected to the AC electric fields in the Y and X directions.

[0037] The storage module 110, the execution module 111, the digital-to-analog conversion module 112, the control module 113, the DC power supply control unit 12, the inverter boost control unit 13, the filter control unit 14, and the AC voltage control unit 15 of the MCU control unit 11 together constitute the AC signal generator 10 of the electric field therapy device 1. The storage module 110, the execution module 111, the control module 113, the direction control unit 16 of the MCU control unit 11, and the X-direction switch 17 and the Y-direction switch 18 electrically connected to the direction control unit 16 together constitute the AC signal controller 20. When the alternating current signal generated by the AC signal generator 10 is applied to the two X-direction electrodes 22, an X-direction alternating electric field 24 is generated between the two X-direction electrodes 22. When the alternating current signal generated by the AC signal generator 10 is applied to the two Y-direction electrodes 21, a Y-direction alternating electric field 23 is generated between the two Y-direction electrodes 21.

[0038] Before the X-direction alternating electric field 24 between the two X-direction electrodes 22 and the Y-direction alternating electric field 23 between the two Y-direction electrodes 21 need to switch directions, the MCU control unit 11 disconnects the communication connection between the digital-to-analog conversion module 112 and the DC power supply control unit 12 through the control module 113, and controls the execution module 111 to stop outputting pulse signals to the inverter boost control unit 13 through the control module 113, so as to avoid the X-direction alternating electric field 24 generated by the two X-direction electrodes 22 and the Y-direction alternating electric field 23 generated by the two Y-direction electrodes 21 being simultaneously turned on to affect the treatment or inhibition effect. After the execution module 111 stops outputting pulse signals to the inverter boost control unit 13 and the communication between the digital-to-analog conversion module 112 and the DC power supply control unit 12 is disconnected, the direction control unit 16 is controlled to switch the X-direction switch 17 and the Y-direction switch 18.

[0039] After the control module 113 of the MCU control unit 11 controls the direction control unit 16 to complete the switching between the X-direction alternating electric field 24 generated between the two X-direction electrodes 22 and the Y-direction alternating electric field 23 generated between the two Y-direction electrodes 21, the control module 113 of the MCU control unit 11 needs to control the digital-to-analog conversion module 112 to output a voltage of 484mV to the DC power control unit 12 to start the DC power control unit 12 and then enable the DC power control unit 12 to output a 20V DC signal to the inverter boost control unit 13. At the same time, the control module 113 controls the execution module 111 to output a 200KHz square wave signal to the inverter boost control unit 13, which is then processed by the filter control unit 14 so that the AC voltage control unit 15 can output a 200KHz, AC voltage peak 160V sine wave to the two X-direction electrodes 22 or the two Y-direction electrodes 21. The value in the DAC data register 1120 corresponding to the 484 mV DC signal output by the digital-to-analog conversion module 112 is 600 (484*4096 / 3300≈600).

[0040] The electric field therapy device 1 of the present invention controls the DC power supply control unit 12 to output a direct current signal in a manner of constant increase or decrease in voltage change per unit time through the control module 113 of the MCU control unit 11 according to the alternating electric signal direction switching cycle obtained by the execution module 111, thereby causing the AC voltage applied between the two pairs of insulated electrodes 2 to slowly increase or slowly decrease within their respective working cycles, so as to avoid the AC voltage sudden change output by the AC voltage control unit 15 generating a spike signal impact when the MCU control unit 11 controls the direction control unit 16 to complete the switching between the X-direction alternating electric field 24 and the Y-direction alternating electric field 23, thereby damaging the X-direction switch 17 and the Y-direction switch 18 of the AC signal controller 20, or the AC voltage sudden change generating a spike pulse transmitted to the X-direction electrodes 22 and the Y-direction electrodes 21 arranged around the tumor site, causing a tingling sensation in the experimental animal or human body, as described below for details.

[0041] Figure 3 Schematic diagram of the periodic direction switching driving signal output by the MCU control unit 11 to the direction control unit 16 so as to generate an X-direction alternating electric field 24 between the two X-direction electrodes 22 for tumor electric field therapy, wherein the driving signal 31 is a partial waveform diagram of the periodic direction switching driving signal, and the signal 41 is a schematic diagram of the sine wave applied to the two X-direction electrodes 22. The working time t1 of the X-direction alternating electric field 24 is the continuous conduction time of the electric field in each cycle in the direction. The stage corresponding to the alternating electric signal switching on period t3 is the process of the AC voltage applied to the two X-direction electrodes 22 being boosted from 0 to a specific value V (the AC voltage value applied to the electrodes), and the stage corresponding to the alternating electric signal switching off period t4 is the process of the AC voltage applied to the two X-direction electrodes 22 being stepped down from a specific value V to 0, and the alternating electric signal switching on period t3 and the alternating electric signal switching off period t4 are the same. In order to eliminate the spike pulse, the MCU control unit 11 controls the change of the value in the DAC data register 1120 to make the DC power control unit 12 output a direct current signal in a manner in which the voltage change is constant within a unit time t, thereby causing the AC voltage output to the AC voltage control unit 15 to be slowly increased during the voltage increase process or slowly decreased during the voltage decrease process. The overall voltage increase V is divided into n equal parts, and the AC voltage increase amplitude within a unit time t is △V=V / n. It is defined that the AC voltage needs to be increased from 0 to a specific voltage V within n unit times t, then the voltage change △V per unit time t is △V=V / n, and the switching-on period t3 of the alternating electric signal is n*t, that is, n=t3 / t. The voltage change △V per unit time t is obtained by the following calculation formula △V =V*t / t3. Similarly, the voltage reduction process also uses a constant voltage change △V to reduce the voltage to eliminate the spike pulse, and the overall voltage reduction is evenly divided into each unit time t. It is defined that the AC voltage needs to be reduced from a specific voltage V to 0 within n unit time t, so the voltage change per unit time t is , the switching off period t4 of the alternating electric signal is n*t, that is, n=t4 / t, and the voltage change △V in the unit time t is obtained by the following calculation formula △V =V*t / t4. That is to say, the AC voltage is boosted to a specific voltage V or reduced to 0 in a certain voltage change △V in the unit time t, and the boost time and the reduction time are different according to the value of the specific voltage.

[0042] Combination Figure 3 As shown, the boost control and buck control for different specific voltages are described in detail below.

[0043] The first boost implementation method: the specific voltage is 100V, the unit time t is set to 1 millisecond, and the voltage change △V is 4V, then n=100 / 4=25, and t3 is 25 milliseconds. That is, the voltage is increased from 0 to 100V with a boost of 4V per 1 millisecond for 25 milliseconds. The DAC data register 1120 value corresponding to the voltage 100V is 375, and the DAC data register 1120 value variable △DAC=375 / 25=15 per unit time t. The MCU control unit 11 increases the DAC data register 1120 value by 15 every 1 millisecond. The output corresponding to the DAC data register 1120 value 4096 is 3.3V. The output corresponding to the DAC data register 1120 value 15 is calculated to be (15*3.3 / 4096)*1000≈12mV. That is to say, the MCU control unit 11 increases the output of DAC112 by about 12mV every 1 millisecond, so that the AC voltage control unit 15 increases the voltage by 4V every millisecond, which lasts for 25 milliseconds. After 25 uniform changes, the AC voltage is increased from 0V to 100V. When the voltage is increased to 100V, even if there is a 100% spike pulse when the voltage suddenly changes, there is only a sudden change voltage of 4V, and 4V accounts for only 4% of 100V. Because the sudden change voltage is still within the 5% error range of the AC voltage output, it can be ignored.

[0044] The second boost implementation method: the specific voltage is 120V, the unit time t is set to 1 millisecond, and the voltage change △V is 4V, then n=120 / 4=30, t3 is 30 milliseconds, that is, the voltage is boosted by 4V every 1 millisecond for 30 milliseconds, and the voltage is raised from 0 to 120V. The value of the DAC data register 1120 corresponding to the voltage 120V is 450, and the value variable of the DAC data register 1120 per unit time t △DAC=450 / 30=15, and the MCU control unit 11 increases the value of the DAC data register 1120 by 15 every 1 millisecond. The output corresponding to the value 4096 of the DAC data register 1120 is 3.3V, and the output corresponding to the value 15 of the DAC data register 1120 is calculated to be (15*3.3 / 4096)*1000≈12mV. That is to say, the MCU control unit 11 increases the DAC112 output by about 12mV per millisecond, causing the AC voltage control unit 15 to increase the voltage by 4V per millisecond for 30 milliseconds. After 30 uniform changes, the voltage is increased from 0V to 120V. When the voltage is increased to 120V, even if there is a 100% spike pulse in the voltage mutation, there is only a 4V mutation voltage, and 4V accounts for only 3.3% of 120V, which still does not reach the 5% error range of the voltage output and can be ignored.

[0045] The third boost implementation method: the specific voltage is 160V, the unit time t is set to 1 millisecond, and the voltage change △V is 4V, then n=160 / 4=40, t3 is 40 milliseconds, that is, the voltage is boosted by 4V every 1 millisecond for 40 milliseconds, and the voltage is increased from 0 to 160V. The DAC data register 1120 value corresponding to the voltage 160V is 600, and the DAC data register 1120 value variable △DAC=600 / 40=15 per unit time t, and the MCU control unit 11 increases the DAC data register 1120 value by 15 every 1 millisecond. The output corresponding to the DAC data register 1120 value 4096 is 3.3V, and the output corresponding to the DAC data register 1120 value 15 is calculated to be (15*3.3 / 4096)*1000≈12mV. That is to say, the MCU control unit 11 increases the DAC112 output by about 12mV per millisecond, causing the AC voltage control unit 15 to increase the voltage by 4V per millisecond for 40 milliseconds. After 40 uniform changes, the voltage is increased from 0V to 160V. When the voltage is increased to 160V, even if there is a 100% spike pulse in the voltage mutation, there is only a 3.2V mutation voltage, and 4V accounts for only 2.5% of 160V, which has not yet reached the 5% error range of the voltage output, and the mutation voltage can be ignored.

[0046] In the above voltage boost implementation, because the average voltage amplitude during t3 is too low and does not reach the target voltage value, the generated AC electric field strength is too low, which has little effect on the mitosis of cancer cells, and the working time t1 of each cycle of the electric field is 1 second.

[0047] The voltage boosting process is a constant voltage boosting process. No matter what the specific value of the AC voltage is, the boosting amount per unit time t is the same. In the above embodiment, taking 4V as an example, the time t3 will become longer as the specific value of the AC voltage becomes larger. The longest time is 160V corresponding to 40 milliseconds. The AC electric field working cycle is 1 second. The voltage boosting process accounts for 4% of the working cycle, which has little effect on the overall treatment time.

[0048] The first step-down implementation method: the specific voltage is 100V, the unit time t is set to 1 millisecond, and the voltage change △V is 4V, then n=100 / 4=25, t4 is 25 milliseconds, that is, the voltage is reduced by 4V every 1 millisecond for 25 milliseconds, and the voltage is reduced from 100V to 0. The DAC data register 1120 value corresponding to the voltage 100V is 375, and the DAC data register 1120 value variable △DAC=375 / 25=15 per unit time t, and the MCU control unit 11 reduces the DAC data register 1120 value by 15 every 1 millisecond. The output corresponding to the DAC data register 1120 value 4096 is 3.3V, and the output corresponding to the DAC data register 1120 value 15 is calculated to be (15*3.3 / 4096)*1000≈12mV. That is to say, the MCU control unit 11 reduces the output of DAC112 by about 12mV per millisecond, so that the AC voltage control unit 15 reduces the voltage by 4V per 1 millisecond, and this lasts for 25 milliseconds. After 25 uniform changes, the voltage is reduced from 100V to 0V. When the voltage is reduced to 0V, even if there is a 100% spike pulse when the voltage suddenly changes, there is only a sudden voltage of 4V, which accounts for only 4% of 100V and has not reached the error range of 5% of the voltage output. The sudden voltage can be ignored.

[0049] The second voltage reduction implementation method: the specific voltage is 120V, the unit time t is set to 1 millisecond, and the voltage change △V is 4V, then n=120 / 4=30, t4 is 30 milliseconds, that is, the voltage is reduced by 4V per millisecond for 30 milliseconds, and the voltage is reduced from 120V to 0. The DAC data register 1120 value corresponding to the voltage 120V is 450, and the DAC data register 1120 value variable △DAC=450 / 30=15 per unit time t, and the MCU control unit 11 reduces the DAC data register 1120 value by 15 per millisecond. The output corresponding to the DAC data register 1120 value 4096 is 3.3V, and the output corresponding to the DAC data register 1120 value 15 is calculated to be (15*3.3 / 4096)*1000≈12mV. That is to say, the MCU control unit 11 reduces the output of DAC112 by about 12mV per millisecond to control the AC voltage control unit 15 to reduce the voltage by 4V per millisecond for 30 milliseconds. After 30 uniform changes, the voltage is reduced from 120V to 0V. When the voltage is reduced to 0V, even if there is a 100% spike pulse when the voltage suddenly changes, there is only a sudden voltage of 4V, which accounts for only 3.3% of 120V and has not reached the error range of 5% of the voltage output. The sudden voltage can be ignored.

[0050] The third voltage reduction implementation method: the specific voltage is 160V, the unit time t is set to 1 millisecond, and the voltage change △V is 4V, then n=160 / 4=40, t4 is 40 milliseconds, that is, the DC power supply control unit 12 reduces the voltage by 4V every 1 millisecond for 40 milliseconds, and reduces the voltage from 160V to 0. The DAC data register 1120 value corresponding to the voltage 160V is 600, and the DAC data register 1120 value variable △DAC=600 / 40=15 per unit time t, and the MCU control unit 11 reduces the DAC data register 1120 value by 15 every 1 millisecond. The output corresponding to the DAC data register 1120 value 4096 is 3.3V, and the output corresponding to the DAC data register 1120 value 15 is calculated to be (15*3.3 / 4096)*1000≈12mV. That is to say, the MCU control unit 11 reduces the output of DAC112 by about 12mV per millisecond to control the AC voltage control unit 15 to reduce the voltage by 4V per millisecond for 40 milliseconds. After 40 uniform changes, the voltage is reduced from 160V to 0V. When the voltage is reduced to 0V, even if there is a 100% spike pulse when the voltage suddenly changes, there is only a sudden voltage of 4V, which accounts for only 2.5% of 160V and has not reached the error range of 5% of the voltage output. The sudden voltage can be ignored.

[0051] In the above voltage reduction implementation, because the average voltage amplitude during t4 is too low and does not reach the target voltage value, the generated AC electric field strength is too low, which has little effect on the mitosis of cancer cells, and the working time t1 of each cycle of the electric field is 1 second.

[0052] The voltage reduction process is a constant voltage reduction process. No matter what the specific value of the AC voltage is, the voltage change △V per unit time t is constant. In the above embodiment, taking 4V as an example, the time t4 will increase as the specific value of the AC voltage increases. The longest time is 160V corresponding to 40 milliseconds. The AC electric field working cycle is 1 second. The voltage reduction process accounts for 4% of the working cycle, which has little effect on the overall treatment time. In this embodiment, the voltage change △V per unit time t in the boost process and the voltage reduction process is the same, both 4V.

[0053] The control module 113 of the MCU control unit 11 of the electric field therapy device 1 of the tumor electric field therapy system 1000 of the present invention controls the DC power supply control unit 12 to output a DC power signal by controlling the value change of the DAC data register 1120 per unit time to increase the voltage slowly at a constant voltage during the voltage increase process and to decrease the voltage slowly at a constant voltage during the voltage decrease process, thereby making the alternating voltage applied by the AC voltage control unit 15 to the two X-direction electrodes 22 or the two Y-direction electrodes 21 increase the voltage slowly during the connection process and decrease the voltage slowly during the disconnection process during their respective periodic working periods, and making the voltage value changed per unit time controlled within 5% of the working AC voltage, thereby preventing the AC voltage applied to the X-direction electrodes 22 and the Y-direction electrodes 21 from generating a sudden change when switching directions to damage the X-direction switch 17 or the Y-direction switch 18 of the AC signal controller 20, and also preventing the experimental animal or human body from generating a tingling sensation due to the sudden change of the AC voltage through the X-direction electrodes 22 and the Y-direction electrodes 21 arranged on the surface of the tumor site.

[0054] The above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A tumor electric field treatment system for applying an alternating electric field to a tumor site or proliferating tumor cells in tissue culture, comprising an electric field treatment device and at least two pairs of insulated electrodes electrically connected to the electric field treatment device, characterized in that: The electric field therapy device includes an MCU control unit, a direction control unit connected to the MCU control unit, a DC power supply control unit electrically connected to the MCU control unit, and an AC voltage control unit connected to both the direction control unit and the MCU control unit. The MCU control unit is configured to control the AC voltage control unit to output an alternating electric signal according to system parameters of the electric field therapy device. The MCU control unit is also configured to drive the direction control unit to circulate, alternately circulate, and alternately apply the alternating electric signal received by the AC voltage control unit to different pairs of insulated electrodes based on the system parameters of the electric field therapy device, so as to realize the switching of the alternating electric signal between different pairs of insulated electrodes. The system parameters of the electric field therapy device include the output AC voltage amplitude, the preset specific voltage, The AC voltage change in a preset unit time and the alternating electric field continuous conduction time t1 of each pair of insulated electrodes in their respective working cycles, wherein the electric field continuous conduction time t1 includes the initial switching on period t3, the intermediate conduction period and the final switching off period t4; within the switching on period t3, the MCU control unit controls the DC power supply control unit so that the AC voltage value applied by the AC voltage control unit to the insulated electrodes slowly increases from 0 to a specific voltage; the specific voltage is set to be no greater than the peak value of the AC voltage amplitude applied by the electric field therapy device to the insulated electrodes during the conduction period; within the switching off period t4, the MCU control unit controls the DC power supply control unit so that the AC voltage value applied by the AC voltage control unit to the insulated electrodes slowly decreases from a specific voltage to 0.

2. The tumor electric field treatment system according to claim 1, characterized in that: A ratio of a voltage variation per millisecond of the AC voltage control unit to the specific voltage is less than 5%.

3. The tumor electric field treatment system according to claim 1, characterized in that: It also includes an inverter boost control unit that is simultaneously connected to the MCU control unit and the DC power supply control unit, and a filter control unit that is connected to the inverter boost control unit. The system parameters of the electric field therapy device include the electric field frequency and the alternating electric signal direction switching period. The MCU control unit generates a pulse signal that is transmitted to the inverter boost control unit based on its reference voltage and the electric field frequency and output AC voltage amplitude of the electric field therapy device.

4. The tumor electric field treatment system according to claim 3, characterized in that: The MCU control unit drives the direction control unit according to the direction switching cycle of the alternating electric signal of the electric field therapy device to cyclically and alternately switch the alternating electric field applied to different insulated electrode pairs through the AC voltage control unit.

5. The tumor electric field treatment system according to claim 3, characterized in that: The MCU control unit controls the conduction and disconnection between it and the DC power supply control unit and whether to output a pulse signal to the inverter boost control unit according to the direction switching cycle of the alternating electric signal of the electric field therapy device.

6. The tumor electric field treatment system according to claim 5, characterized in that: The direction control unit is configured to switch after the MCU control unit disconnects the communication between the MCU control unit and the DC power supply control unit and the MCU control unit stops outputting the pulse signal to the inverter boost control unit.

7. The tumor electric field treatment system according to claim 6, characterized in that: The MCU control unit starts the DC power control unit after the direction control unit performs the switching and controls the DC power control unit to output a direct current signal to the inverter boost control unit and simultaneously output a pulse signal to the inverter boost control unit.

8. The tumor electric field treatment system according to claim 1, characterized in that: The switching-on period t3 is determined by: t3=V / ΔV*t, wherein V is a specific voltage, t is 1 millisecond, and ΔV is a voltage change amount of the AC voltage control unit per millisecond.

9. The tumor electric field treatment system according to claim 1, characterized in that: The alternating electric signal is increased uniformly from 0 to a specific voltage in a manner of a voltage change of 4V per millisecond during the switching-on time period t3.

10. The tumor electric field treatment system according to claim 1, characterized in that: The MCU control unit includes a digital-to-analog conversion module with a DAC data register. The MCU control unit calculates the voltage output increment of the digital-to-analog conversion module per millisecond based on its reference voltage, the voltage change of the AC voltage control unit per millisecond, the specific voltage, and the DAC data register value corresponding to the specific voltage.

11. The tumor electric field treatment system according to claim 10, characterized in that: The MCU control unit calculates the voltage output decrement of the digital-to-analog conversion module per millisecond based on its reference voltage, the voltage change of the AC voltage control unit per millisecond, the specific voltage, and the DAC data register value corresponding to the specific voltage.

12. The tumor electric field treatment system according to claim 11, characterized in that: The voltage output increment or decrement of the digital-to-analog conversion module per millisecond is determined as follows: , where △V DAC The voltage output increment or decrement of the digital-to-analog conversion module every millisecond, in millivolts; the MCU reference voltage is 3.3V, and the DAC data register value corresponding to the MCU reference voltage is 4096=2 12 ; △V is the voltage change of the AC voltage control unit per millisecond, in volts; V is the specific voltage, in volts; DAC is the DAC data register value of the specific voltage in the DAC data register.

13. The tumor electric field treatment system according to claim 1, characterized in that: The switching off period t4 is obtained by the following method: t4=V / ΔV*t, wherein V is a specific voltage, t is 1 millisecond, and ΔV is a voltage change of the AC voltage control unit per millisecond.

14. The tumor electric field treatment system according to claim 1, characterized in that: The alternating electric signal decreases uniformly from a specific voltage to 0 at a voltage variation of 4 V per millisecond during the switching-off time period t4.

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