A triple-band electromagnetically induced transparent metamaterial antibiotic sensing chip

Abstract

The present solution provides a three-band electromagnetically induced transparent metamaterial antibiotic sensor chip comprising: at least one sensor unit, wherein each sensor unit comprises a substrate layer and a π-type resonance unit and a rectangular resonance unit disposed on the substrate layer and spaced apart from each other, wherein the π-type resonance unit comprises a horizontal bar disposed transversely and two first and second vertical bars disposed perpendicularly relative to the horizontal bar, a π-type opening is formed between the first and second vertical bars, wherein the rectangular resonance unit is a rectangular closed-loop structure, and the opening direction of the π-type opening is arranged directly opposite to the rectangular resonance unit; multi-mode coupling occurs between the π-type resonance unit and the rectangular resonance unit, and interference destructive interaction generates three transparent window resonance peaks at three different frequencies, thereby realizing simultaneous detection of three antibiotics.

Description

Technical Field

[0001] The invention relates to an antibiotic sensor chip, in particular to a triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip. Background Art

[0002] With the widespread use of antibiotics in medicine, agriculture and food industry, the problem of antibiotic residues is becoming increasingly serious, posing a potential threat to human health and the ecological environment. Therefore, the development of efficient and sensitive antibiotic detection technology has become the focus of current research. Metamaterial sensors, due to their unique electromagnetic properties and high sensitivity, have shown great application potential in the field of antibiotic detection.

[0003] However, most existing metamaterial sensors have a single detection peak, which greatly limits their flexibility and versatility in actual complex detection scenarios. Specifically, they can only sense and detect a single antibiotic at a specific, fixed frequency, and it is difficult to detect multiple antibiotics simultaneously. In actual application scenarios, it is often necessary to face the detection needs of multiple antibiotics at the same time, such as the analysis of different antibiotic components in compound pharmaceutical preparations in the medical field, or the simultaneous detection of multiple antibiotic residues in the field of food safety monitoring. The mode of detecting a single antibiotic with a single transparent window and a fixed frequency is obviously difficult to meet these diversified and complex actual needs, which has undoubtedly become a key factor restricting the sensor from further large-scale practical applications.

[0004] Of course, there are also a small number of metamaterial sensor chips that can detect different antibiotics. For example, CN113138176A provides a terahertz metamaterial sensor and its application. By designing an asymmetric open ring structure, Fano resonance and electric dipole resonance are simultaneously generated, thereby realizing the detection of two resonance peaks. However, most of them can only realize dual-band or limited-band detection, which is still difficult to meet the actual needs of simultaneous detection of multiple different antibiotics. Summary of the invention

[0005] The purpose of the present invention is to provide a three-band electromagnetically induced transparent metamaterial antibiotic sensor chip, which can form three transparent window resonance peaks corresponding to three antibiotics, thereby realizing simultaneous detection of the three antibiotics.

[0006] To achieve the above objectives, the present technical solution provides a three-band electromagnetically induced transparent metamaterial antibiotic sensor chip comprising: at least one sensor unit, wherein each sensor unit comprises a substrate layer and a π-type resonance unit and a rectangular resonance unit disposed on the substrate layer and spaced apart from each other, wherein the π-type resonance unit 10 comprises a horizontally disposed horizontal bar and two first and second vertical bars disposed perpendicularly relative to the horizontal bar, a π-type opening is formed between the first and second vertical bars, wherein the rectangular resonance unit is a rectangular closed-loop structure, and the opening direction of the π-type opening is arranged opposite to the rectangular resonance unit; multi-mode coupling occurs between the π-type resonance unit and the rectangular resonance unit, and interference destructive interaction generates three transparent window resonance peaks at three different frequencies.

[0007] Compared with the prior art, this technical solution has the following characteristics and beneficial effects:

[0008] The three-band electromagnetically induced transparent metamaterial antibiotic sensor chip provided by this solution can generate three transparent window resonance peaks of different frequencies, corresponding to the fingerprint spectra of chlortetracycline, tetracycline and penicillin sodium, respectively, to achieve simultaneous detection of multiple antibiotics, breaking through the limitation that the existing technology may only be able to detect a single or a few antibiotics. Through chip structure design and parameter adjustment, when the transparent window resonance peak is close to the frequency position of the corresponding antibiotic fingerprint spectrum, the coupling effect effectively improves the sensing sensitivity. Slight changes in the metamaterial structure will bring about large changes in the electromagnetic response, which can be reflected by the transmission curve, and the π-type resonance unit has rich electromagnetic response, which can generate 3 transparent window resonance peaks for sensing detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 This is the overall structural diagram of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip provided in this scheme.

[0010] Figure 2 This is a schematic diagram of the structure of the sensing unit of the three-band electromagnetically induced transparent metamaterial antibiotic sensing chip provided in this scheme.

[0011] Figure 3 This is a transmission curve diagram of the simulated resonant unit of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip provided in this solution.

[0012] Figure 4 This is the electric field distribution diagram of the sensing unit of the three-band electromagnetically induced transparent metamaterial antibiotic sensing chip provided by this scheme.

[0013] Figure 5 This is a curve diagram showing the change in the transmission curve of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip and the refractive index of the object to be measured provided by this solution.

[0014] Figure 6This is a linear fitting diagram of the three window frequency shift values ​​of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip provided by this scheme and the refractive index of the object to be tested.

[0015] In the figure: 10-π-type resonant unit, 20-rectangular resonant unit, 11-horizontal bar, 12-first vertical bar, 13-second vertical bar, 100-π-type opening. DETAILED DESCRIPTION

[0016] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0017] Those skilled in the art should understand that, in the disclosure of the present invention, the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, which are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation. Therefore, the above terms should not be understood as limiting the present invention.

[0018] Embodiment 1

[0019] This scheme provides a three-band electromagnetically induced transparent metamaterial antibiotic sensor chip, which can generate transparent window resonance peaks of different frequencies, corresponding to the fingerprint spectra of three antibiotics, so as to detect multiple antibiotics simultaneously.

[0020] like Figure 1 As shown, the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip provided by this solution includes:

[0021] At least one sensing unit, wherein each sensing unit comprises a substrate layer and a π-type resonance unit 10 and a rectangular resonance unit 20 disposed on the substrate layer and spaced apart from each other, wherein the π-type resonance unit 10 comprises a horizontal bar 11 disposed horizontally and two first vertical bars 12 and second vertical bars 13 disposed perpendicularly relative to the horizontal bar 11, a π-type opening 100 is formed between the first vertical bar 12 and the second vertical bar 13, wherein the rectangular resonance unit 20 is a rectangular closed-loop structure, and an opening direction of the π-type opening 100 is disposed directly opposite to the rectangular resonance unit 20;

[0022] Multi-mode coupling occurs between the π-type resonance unit 10 and the rectangular resonance unit 20 , and interference destructive interaction generates three transparent window resonance peaks at three different frequencies.

[0023] In some embodiments, the material of the π-type resonant unit 10 and the rectangular resonant unit 20 is copper metal, and the substrate layer is quartz. Specifically, the electrical conductivity of copper metal is 5.96×10 7 S / m, and the relative dielectric constant of quartz is 1.9. The reason why this scheme chooses a material with a low dielectric constant as the material of the substrate layer is to enhance the sensing performance of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip.

[0024] In some embodiments, the π-type resonance unit 10 and the rectangular resonance unit 20 have the same thickness, which is between 0.15µm and 0.25µm, and preferably 0.2µm. The substrate layer has a thickness of 35-50µm, and preferably 40µm.

[0025] In some embodiments, the length of the horizontal bar 11 of the π-type resonance unit 10 is 272µm-276µm, the length of the first vertical bar 12 and the second vertical bar 13 is 80µm-84µm, and the width of the π-type opening 100 is 124µm-128µm.

[0026] In some embodiments, the rectangular resonance unit 20 includes two parallel long sides and two parallel short sides, and the long sides and the short sides are arranged vertically, and the length of the long side is greater than the length of the short side. Specifically, the long side of the rectangular resonance unit 20 is arranged parallel to the horizontal strip 11 of the π-type resonance unit 10, and the opening of the π-type opening 100 is arranged opposite to the long side of the rectangular resonance unit 20.

[0027] In some embodiments, the length of the long side of the rectangular resonant unit 20 is 150 μm to 154 μm, and the length of the short side is 86 μm to 90 μm.

[0028] In some embodiments, the substrate layer is a square structure, and the side length of the substrate layer is 175µm~185µm.

[0029] Correspondingly, the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip of this scheme produces transparent window resonance peaks at 0.76THz, 0.79THz and 0.85THz, corresponding to the fingerprint spectra of chlortetracycline, tetracycline and sodium penicillin, respectively, and the corresponding three transparent window resonance peaks are bright-bright-bright coupling, bright-dark-bright coupling and bright-dark-bright coupling modes.

[0030] This scheme uses the structural design and parameter adjustment of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip to generate three transparent window resonance peaks corresponding to chlortetracycline, tetracycline and penicillin sodium. When the transparent window resonance peak is close to the frequency position of the fingerprint spectrum of the corresponding antibiotic, this coupling effect can effectively improve the sensing sensitivity. It should be emphasized that slight changes in the metamaterial structure will lead to large changes in its electromagnetic response, which can be reflected by the transmission curve. The π-type resonant unit of this scheme has a richer electromagnetic response. Through the electric field analysis of the formation mode of its EIT window, it can be seen that the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip of this scheme can generate three transparent window resonance peaks, which can realize the sensing detection of three antibiotics.

[0031] like Figure 2 As shown, preferably, the length of the horizontal bar 11 of the π-type resonance unit 10 is c is 274µm, and the length of the first vertical bar 12 and the second vertical bar 13 is d The width of the π-shaped opening is 82µm and 100 g The long side of the rectangular resonant unit 20 is 126µm. l The length is 152µm, the short side w The length of the substrate layer is 88µm. Px and Py 180µm.

[0032] In some embodiments, the sensing units of the triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip are arranged in a periodic array.

[0033] This solution uses CST Studio Suite electromagnetic simulation software to complete the simulation of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip. During the simulation, the boundary conditions of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip unit in the x and y directions are set as unit cell boundaries, and the z direction is open (add space) boundary, so as to simulate an infinite metamaterial periodic array, select THz plane waves with incident direction z as the excitation source, and set the simulation frequency band to 0.3-1THz.

[0034] This scheme simulates the π-type resonant unit and the rectangular resonant unit respectively. The simulated transmission curve is shown in the figure below. Figure 3 As shown in Figure 2, the contribution of the three transparent windows is studied. Figure 3 Curve R1 represents the transmission curve when the π-type resonance unit is simulated alone, curve R2 represents the transmission curve when the rectangular resonance unit is simulated alone, and curve R3 represents the transmission curve of the overall sensor chip simulation. It can be seen that the three transparent windows are formed by coupling of multiple modes.

[0035] Next, we analyze its formation mode by combining the electric field distribution diagram and obtain the electric field distribution diagrams at seven key points with frequencies from low to high as shown in the figure below: Figure 4 As shown, Figure 4 (a) in the figure represents the first trough. Figure 4 (b) in the figure represents the first transparent window. Figure 4 (c) in the figure indicates the second trough. Figure 4 (d) in the figure indicates the second transparent window. Figure 4 (e) in the graph represents the third trough. Figure 4 (f) in the figure indicates the third transparent window. Figure 4 (g) in the figure indicates the fourth trough. The electric field distribution is divided into three parts for analysis, namely the horizontal bar P1 of the π-type resonance unit, the first and second vertical bars P2 of the π-type resonance unit, and the rectangular resonance unit as a whole P3. It can be seen that P2 and P3 are excited at the first trough, and only P1 is excited at the second trough. The three are all in an over-bright state before and after the first transparent window. The first transparent window is a bright-bright-bright coupling mode, and the electric field energy is gathered between the horizontal bar, the first and second vertical bars of the π-type resonance unit, and the rectangular resonance unit. Only P2 is strongly excited at the third trough, and P3 is not excited before and after the second transparent window. The second transmission window is a bright-dark-bright coupling mode, and the electric field energy is only gathered in the horizontal bar and two vertical bars of the π-type resonance unit. P1 is strongly excited at the fourth trough, and P3 is not excited before and after the third transparent window. The third transmission window is a bright-dark-bright coupling mode, and the electric field energy is only concentrated on the upper side and two arms of the π-type resonator. In summary, the three transparent windows are bright-bright-bright coupling, bright-dark-bright coupling and bright-dark-bright coupling modes respectively.

[0036] In addition, in order to test the sensitivity of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip to the analyte, this scheme tests the response of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip to different concentrations of the analyte. The test results are as follows: Figure 5 As shown, the analytes in this scheme are chlortetracycline, tetracycline and penicillin sodium.

[0037] like Figure 5As shown, different concentrations of the objects to be tested have different refractive indices, and the transparent window of the EIT effect will change significantly with a slight change in the refractive index of the object to be tested above the device. Based on this, sensing detection of the object to be tested can be achieved. When the refractive index of the object to be measured increases from 1.0 to 1.3 in steps of 0.1, the three transmission window resonance peaks all undergo frequency shifts to varying degrees. The resonance frequency of the first transmission window resonance peak moves from 0.755THz to 0.706THz, and corresponding to each refractive index of the object to be measured, the frequency shift of the first transparent window resonance peak is 164, 163, and 163THz, resulting in a total redshift of 490GHz; the resonance frequency of the second transmission window resonance peak moves from 0.798THz to 0.770THz, and corresponding to each refractive index of the object to be measured, the frequency shift of the second transparent window resonance peak is 95, 93, and 92 THz, resulting in a total redshift of 280GHz; the resonance frequency of the third transmission window resonance peak moves from 0.848THz to 0.802THz, and the frequency shift of the third transparent window resonance peak is 154, 154, and 152THz, resulting in a total redshift of 460GHz. By comparing with each other, it can be seen that the sensitivity of the three transmission window resonance peaks to the change of the refractive index of the object to be measured is, from low to high, the first transmission window resonance peak, the third transmission window resonance peak and the second transmission window resonance peak. The difference in sensitivity is caused by the different electromagnetic responses of the coupling fields of each transparent window to the object to be measured.

[0038] As mentioned above, it can be seen that by changing the refractive index of the object to be tested, the frequency shift of the EIT window peak of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip can be achieved. Therefore, the performance of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip depends on the sensitivity to the refractive index of the surrounding environment. The three values ​​of sensitivity, quality factor Q and FOM can be used to characterize the performance of the three-band electromagnetically induced transparent metamaterial antibiotic sensor chip.

[0039] (1) Sensitivity S, which indicates the relationship between the refractive index change of the object to be measured on the sensor surface and the window frequency shift. In experimental measurements, changes in the concentration of the object to be measured will cause changes in the refractive index. The commonly used unit of sensitivity is GHz / RIU. The specific formula is as follows:

[0040] (1);

[0041] is the change in refractive index, To change the frequency shift of the transparent window corresponding to the refractive index of the object to be measured.

[0042] (2) Quality factor Q, which indicates the resonance characteristics of the sensor. The sharper the peak at the transparent window, the higher the corresponding Q value. A high Q value can overcome a large amount of electromagnetic wave radiation loss. The Q value calculation formula is:

[0043] (2)

[0044] is the center frequency of the transparent window, and FWHM is the half-wave full width of the transparent window peak.

[0045] (3) FOM value, which is a comprehensive indicator of sensor performance and can be used to compare the performance of multiple sensors. The calculation formula of FOM is:

[0046] (3)

[0047] In order to more accurately express the sensitivity, a linear fit is performed on the refractive index change of each transparent window relative to the surrounding test object to obtain the fitting results as follows: Figure 6 As shown, S 1 , S 2 and S 3 They represent the first, second and third transparent windows respectively. The slope of the fitted straight line is the sensitivity of the corresponding transparent window. The slopes of the three fitted straight lines are expressed by k 1 , k 2 and k 3 It means that k 1 =-0.163, k 2 =-0.093, k 3 =-0.155, its R 2 are 0.99977, 0.99931 and 0.9938 respectively, so the sensitivities of the three transparent windows are S 1 =163GHz / RIU, S 2 =93GHz / RIU, S 3 =155GHz / RIU. The center frequencies of the three transparent windows are 0.755THz, 0.795THz and 0.848THz, and the half-height widths are 0.051THz, 0.043THz and 0.032THz, respectively. The Q values ​​are 14.8, 18.5 and 26.5, and the FOMs are 3.2, 2.2 and 4.8, respectively. The sensing performances of the three transparent windows are somewhat different, and the specific sensing detection of chlortetracycline, tetracycline and penicillin sodium can be realized at the corresponding frequencies.

[0048] Those skilled in the art should understand that the technical features of the above embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0049] The above embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. A three-band electromagnetically induced transparent metamaterial antibiotic sensor chip, characterized in that: include: At least one sensing unit, wherein each sensing unit comprises a substrate layer and a π-type resonance unit (10) and a rectangular resonance unit (20) disposed on the substrate layer and spaced apart from each other, wherein the π-type resonance unit (10) comprises a horizontally disposed horizontal bar (11) and two vertical bars (12) and (13) disposed perpendicularly to the horizontal bar (11), a π-type opening (100) is formed between the first vertical bar (12) and the second vertical bar (13), the horizontal bar (11) of the π-type resonance unit (10) has a length of 272µm to 276µm, the first vertical bar (12) and the second vertical bar (13) have a length of 80µm to 84µm, and the width of the π-type opening (100) is 124µm to 128µm; The rectangular resonance unit (20) is a rectangular closed-loop structure, the rectangular resonance unit (20) comprises two parallel long sides and two parallel short sides, the long sides and the short sides are arranged perpendicularly, the length of the long sides is greater than the length of the short sides, the long sides of the rectangular resonance unit (20) are arranged parallel to the horizontal strips (11) of the π-type resonance unit (10), and the opening of the π-type opening (100) is arranged opposite to the long sides of the rectangular resonance unit (20); Multi-mode coupling occurs between the π-type resonance unit (10) and the rectangular resonance unit (20), and interference destructive interaction generates three transparent window resonance peaks at three different frequencies.

2. The triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip according to claim 1, characterized in that: The length of the long side of the rectangular resonant unit (20) is 150µm to 154µm, and the length of the short side is 86µm to 90µm.

3. The triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip according to claim 1, characterized in that: The substrate layer has a square structure, and the side length of the substrate layer is 175µm~185µm.

4. The triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip according to claim 1, characterized in that: Transparent window resonance peaks are generated at 0.76THz, 0.79THz and 0.85THz, corresponding to the fingerprint spectra of chlortetracycline, tetracycline and penicillin sodium, respectively.

5. The triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip according to claim 1, characterized in that: The three transparent window resonance peaks are bright-bright-bright coupling, bright-dark-bright coupling and bright-dark-bright coupling modes.

6. The triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip according to claim 1, characterized in that: The π-type resonance unit (10) and the rectangular resonance unit (20) are made of metal copper, and the substrate layer is quartz.

7. The triple-band electromagnetically induced transparent metamaterial antibiotic sensor chip according to claim 1, characterized in that: The π-type resonance unit (10) and the rectangular resonance unit (20) have the same thickness, which is between 0.15µm and 0.25µm, and the thickness of the substrate layer is between 35µm and 50µm.

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