Method and device for evaluating cool feeling effect of daily chemical product

Abstract

The invention discloses a method and a device for evaluating a cool feeling effect of a daily chemical product. The method comprises the following steps: (1) collecting evaluation parameter information before and after a subject uses the daily chemical product; the evaluation parameters comprise a first parameter and an optional second parameter; the first parameters comprise at least one of a TiVi value, a redness value, a percutaneous water loss rate and a pore area; the second parameter comprises the number of pores and / or porphyrin; (2) calculating results of the evaluation parameter information before and after the daily chemical product is used; and (3) analyzing and evaluating the cool feeling effect of the daily chemical product according to the result. According to the method for evaluating the cool feeling effect of the daily chemical product, the cool feeling effect of the product is evaluated by collecting objective evaluation parameter information, and errors caused by existing measurement indexes and subjective evaluation of consumers can be effectively avoided, so that the cool feeling effect of the product is objectively evaluated more objectively, more comprehensively and more scientifically.

Description

Technical Field

[0001] The invention belongs to the technical field of daily chemical product evaluation, and in particular, relates to a method and a device for evaluating the cooling effect of daily chemical products. Background Art

[0002] Thermal energy in daily life causes skin temperature to increase through various transmission methods. Relevant studies have shown that overheating can stimulate the TRPV-1 ion channel in the epidermis, triggering inflammatory cascades and oxidative stress, leading to sensitive reactions such as redness and capillary dilation, reduced skin barrier function, enlarged pores, and more oil secretion by sebaceous glands.

[0003] Cool sensation refers to the cool feeling caused by the rapid loss of heat from the skin surface and the instantaneous drop in temperature, or the cool feeling "felt" through nerve induction. Appropriately lowering the skin temperature can relieve the discomfort symptoms caused by heat stimulation. At present, the cooling effect of daily chemical products is generally verified by single or fewer evaluation indicators such as the area of ​​the skin red zone, and subjective evaluation methods of consumer questionnaires. The evaluation method for the cooling effect of daily chemical products has not yet been perfected, and there are no relevant industry requirements, systems and industry standards. Therefore, how to evaluate the cooling effect of daily chemical products more objectively, scientifically and comprehensively has become an urgent problem to be solved. Summary of the invention

[0004] The technical problem solved by the invention is how to evaluate the cooling effect of daily chemical products more objectively, scientifically and comprehensively.

[0005] The technical solution provided by the present invention is as follows:

[0006] A first aspect of the present invention provides a method for evaluating the cooling effect of a daily chemical product, comprising the following steps:

[0007] (1) collecting evaluation parameter information of the subjects before and after using the daily chemical products;

[0008] The evaluation parameters include a first parameter and an optional second parameter; the first parameter includes at least one of a TiVi value, a redness value, a transepidermal water loss rate and a pore area; the second parameter includes the number of pores and / or porphyrin;

[0009] (2) calculating the results of the evaluation parameter information before and after using the daily chemical product;

[0010] (3) Analyze and evaluate the cooling effect of daily chemical products based on the results:

[0011] If the result of at least one evaluation parameter at any time point is statistically significantly different before and after using the daily chemical product or compared with the negative / blank control, it means that the product has a cooling effect; otherwise, it means that the product does not have a cooling effect.

[0012] A second aspect of the present invention provides a device for evaluating the cooling effect of daily chemical products, the device comprising:

[0013] A collection module, used to collect evaluation parameter information of the subject before and after using the daily chemical product;

[0014] A calculation module, used for calculating the results of the evaluation parameter information before and after using the daily chemical product;

[0015] An evaluation module is used to evaluate the cooling effect of the daily chemical product according to the result calculated by the calculation module.

[0016] The third aspect of the present invention provides an electronic system, comprising: a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein when the processor executes the program, the method for evaluating the cooling effect of daily chemical products as described above is implemented.

[0017] A fourth aspect of the present invention provides a computer-readable storage medium storing computer-executable instructions for causing a computer to execute the above-mentioned method for evaluating the cooling effect of daily chemical products.

[0018] The beneficial effects of the present invention include at least:

[0019] The cooling effect evaluation method of daily chemical products of the present invention evaluates the cooling effect of products by collecting objective evaluation parameter information. Different from the currently commonly used method for evaluating the cooling effect of products, the method can effectively avoid the errors caused by existing measurement indicators and subjective evaluations of consumers, thereby making an objective evaluation of the cooling effect of the product in a more objective, comprehensive and scientific manner. The method is suitable for promotion and application in the cooling effect evaluation of any daily chemical products that contact the skin, and has important practical significance.

[0020] Other features and advantages of the present invention will be described in detail in the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The present invention is a schematic flow chart of a method for evaluating the cooling effect of a daily chemical product.

[0022] Figure 2This is a graph showing the changes in skin TiVi value, redness value, transepidermal water loss, pore area, number of pores, porphyrin and environment / skin temperature in Example 1 of the present invention.

[0023] Figure 3 1 is a graph showing the change in TiVi value results and the difference analysis before and after using the mosquito repellent liquid in Example 2 of the present invention.

[0024] Figure 4 1. It is a graph showing the change in transepidermal water loss results and the difference analysis before and after using the gel in Example 3 of the present invention.

[0025] Figure 5 This is a graph showing the change in redness value results and the difference analysis before and after using the essence water in Example 4 of the present invention.

[0026] Figure 6 3 are images of pores before and after using essence water in Example 4 of the present invention, wherein (a) is the image of pores before use, and (b) is the image of pores after use.

[0027] Figure 7 1 and 2 are TiVi images before and after using mosquito repellent liquid in Example 2 of the present invention, wherein (a) is the TiVi image before use, and (b) is the TiVi image after use.

[0028] Figure 8 3 are redness value images before and after using the gel product in Example 3 of the present invention, wherein (a) is the redness value image before use, and (b) is the redness value image after use. DETAILED DESCRIPTION

[0029] In order to make the purpose, technical scheme and beneficial effects of the present invention clearer, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods or embodiments or examples. It should be understood that the specific contents described in the following implementation methods or embodiments or examples of the present invention are only exemplary and are intended to be used to explain the present invention, but do not constitute a limitation of the present invention.

[0030] The first aspect of the present invention provides a method for evaluating the cooling effect of daily chemical products, the process is as follows: Figure 1 As shown, the following steps are included:

[0031] (1) collecting evaluation parameter information of the subjects before and after using the daily chemical products;

[0032] The evaluation parameters include a first parameter and an optional second parameter; the first parameter includes at least one of a TiVi value, a redness value, a transepidermal water loss rate and a pore area; the second parameter includes the number of pores and / or porphyrin;

[0033] (2) calculating the results of the evaluation parameter information before and after using the daily chemical product;

[0034] (3) Analyze and evaluate the cooling effect of daily chemical products based on the results:

[0035] If the result of at least one evaluation parameter at any time point is statistically significantly different before and after using the daily chemical product or compared with the negative / blank control, it means that the product has a cooling effect; otherwise, it means that the product does not have a cooling effect.

[0036] At present, daily chemical products on the market usually act on the skin surface in different ways to produce a cool feeling on the skin surface, such as applying, spraying, and misting. For example: daily chemical products that produce a cool feeling on the skin surface by applying can relieve capillary dilation, congestion, skin burning, swelling, redness, etc., or appropriately restore the skin barrier function, or reduce the sebaceous glands from secreting oil, etc. The types and mechanisms of action of common daily chemical products on the market that produce a cool feeling on the skin surface vary. For example, floral water uses the volatility of ethanol to absorb heat through evaporation to produce a cool feeling; gel and jelly-textured dosage products use the high specific heat capacity of water to achieve a cooling effect and can prolong the cooling time; products with added cooling agents such as menthol and borneol can make the human nerves sense a cool experience similar to cooling, etc.

[0037] In the present invention, daily chemical products may also be referred to as products. In the present invention, daily chemical products are any daily chemical products that can contact the skin. In some preferred embodiments, the daily chemical products include at least one of cosmetic products, disinfection products, mechanical products, special products and pesticide products.

[0038] In some embodiments, the pesticide product comprises a mosquito repellent product.

[0039] Since daily chemical products act on the skin surface to produce a cool feeling on the skin surface, the skin physiology or biochemistry will change before and after use. Therefore, in the present invention, by collecting evaluation parameter information including skin physiology or biochemistry data information or image information, calculating the results of the evaluation parameter information, and then analyzing and evaluating the cooling effect of the daily chemical products according to the results, if the results of at least one evaluation parameter information at any time point are statistically significantly different compared with before and after using the daily chemical products or compared with the negative / blank control, it means that there is a cooling effect, otherwise it means that there is no cooling effect. The technical solution of the present invention can evaluate the cooling effect of daily chemical products more objectively, scientifically and comprehensively.

[0040] In some embodiments of the present invention, the evaluation parameter information includes skin physiological or biochemical data information or image information.

[0041] In the present invention, the first parameter and the second parameter are distinguished only based on whether they are obviously affected by temperature changes. The parameter that is obviously affected by temperature changes is the first parameter, and the parameter that is not obviously affected by temperature changes is the second parameter. However, it should be noted that both the first parameter and the second parameter can be used as a basis for determining the cooling effect of daily chemical products.

[0042] After exploration by the inventors, it was found that under the same conditions, compared with the second parameter, the first parameter is directly related to the change of subcutaneous blood flow velocity, transdermal absorption capacity, and the degree of pore contraction, and is significantly related to temperature changes. The second parameter is a parameter that acts through the mediation of the first parameter (such as showing significant changes only after being affected by the pore contraction effect and the water-oil balance change effect).

[0043] For common daily chemical products on the market (with multiple functions), the first parameter changes significantly after use by the subjects, but the second parameter may only have a trend of change. For products with high concentrations of active ingredients / obvious dosage form characteristics, it can be seen that both the first and second parameters change significantly; while in some other products, only the second parameter changes significantly. In short, depending on the different mechanisms of the cooling effect of the product, it will be reflected in different evaluation parameters (including the first parameter and / or the second parameter), and the product has a significant effect on at least one of the first parameter or the second parameter.

[0044] In some embodiments, the cooling effect of daily chemical products is based on the results of the first parameter and the second parameter. Wherein, the result of the first parameter is used as the main basis for judging that the daily chemical products have cooling effects. Wherein, before and after using the product or compared with the negative / blank control, the change results of at least one first parameter (including TiVi value, redness value, transepidermal water loss rate, pore area) at any time point are significantly different (p<0.05), indicating that the daily chemical products have cooling effects, otherwise the daily chemical products do not have cooling effects. The result of the second parameter can also be used as an auxiliary indicator for determining cooling to indirectly prove that the test product has cooling effects. Wherein, before and after using the product or compared with the negative / blank control, the change results of at least one second parameter (including the number of pores, porphyrin) at any time point are significantly different (p<0.05), indicating that the daily chemical products have improved the second parameter and have cooling effects, otherwise the daily chemical products do not have cooling effects.

[0045] In some embodiments, the result of the improvement of the first parameter is used as the basis for determining whether the test product has a cooling effect. Wherein, if the change result of at least one first parameter (including TiVi value, redness value, transepidermal water loss rate, pore area) at any time point before and after using the product or compared with the negative / blank control is significantly different (p<0.05), it means that the daily chemical product has a cooling effect, otherwise the daily chemical product does not have a cooling effect.

[0046] In some embodiments, the result of the improvement of the second parameter is used as a basis for determining whether the product has a cooling effect. If the change result of at least one second parameter (including the number of pores and porphyrin) at any time point before and after using the product or compared with the negative / blank control is significantly different (p<0.05), it means that the daily chemical product has a cooling effect, otherwise the daily chemical product does not have a cooling effect.

[0047] In the present invention, the collected evaluation parameter information can come from the subject's entire skin or any body tissue that can reflect the skin condition, including but not limited to facial and body skin, blood, and body fluids.

[0048] In the present invention, the method for evaluating the cooling effect of daily chemical products comprises collecting evaluation parameter information of the skin in a non-invasive manner or an invasive manner. In some preferred embodiments, collecting the evaluation parameter information of the skin in a non-invasive manner has the advantages of being non-invasive, convenient, and easy to accept.

[0049] In some embodiments, at least one of the epidermis, dermis, and subcutaneous tissue is detected to collect skin evaluation parameter information.

[0050] In some embodiments, the detection includes but is not limited to at least one of epithelial tissue, muscle tissue, connective tissue (such as blood, blood vessels, etc.), nerve tissue and body fluid to collect evaluation parameter information of the skin.

[0051] In some embodiments of the present invention, in step (1), the evaluation parameter information includes skin physiological or biochemical data information or image information.

[0052] In the present invention, a skin image analyzer (such as a facial image analyzer) can be used to collect evaluation parameter information such as redness value, pore area, number of pores, porphyrin, etc. Specifically, it includes but is not limited to a shooting system / high-definition digital camera that has a visible light / polarized light filter and has a high-definition pixel (pixel not less than 15 million) two-dimensional or three-dimensional image acquisition function such as a VISIA-CR facial image analyzer, an Antera 3D CS multifunctional skin imaging analyzer, or an imaging analyzer with a function of photographing the subcutaneous red zone, or other professional image analysis equipment with the same function.

[0053] In the present invention, the information collection of TiVi value can adopt a skin sensitivity tester or other testing instruments capable of measuring the TiVi value of the skin, such as TiVi700 series skin sensitivity tester.

[0054] In the present invention, the information of transepidermal water loss rate is collected by using a transepidermal water loss testing device, which may be an instrument with the function of measuring transepidermal water loss rate (TEWL value) or an instrument with the function of measuring transepidermal water loss rate, such as a VapoMeter transepidermal water loss measuring instrument.

[0055] In the present invention, the image analysis software includes software that is configured in the image analysis instrument or is capable of analyzing pore area, pore number, porphyrin, redness average parameter or data function software of the same degree.

[0056] In the present invention, after using the daily chemical product, the smaller the TiVi value of the skin, the slower the subcutaneous blood flow speed, and the more obvious the cooling effect of the product. In some embodiments, after using the daily chemical product, the lower the skin temperature, the darker the blue color displayed by the image information, and the better the cooling effect of the product.

[0057] In some preferred embodiments, the evaluation of the skin TiVi value includes: collecting skin images using a skin sensitivity tester and analyzing the skin TiVi value. The smaller the skin TiVi value, the slower the subcutaneous blood flow rate and the more obvious the cooling effect of the product.

[0058] In the present invention, after using the daily chemical product, the lower the value of the redness value, the better the cooling effect of the product. In some embodiments, after using the daily chemical product, the lighter the red color displayed by the image of the redness value, the lower the skin temperature, the slower the subcutaneous blood flow rate, and the better the cooling effect of the product.

[0059] In some preferred embodiments, the evaluation of the skin redness value includes: using an Antera 3D CS multifunctional skin imaging analyzer to collect skin images and analyze the skin redness value. The lower the skin temperature, the lighter the red color displayed in the image, and the better the cooling effect of the product.

[0060] In the present invention, after using the daily chemical product, the lower the value of the transepidermal water loss rate is, the better the skin barrier is, indicating that the product has a better water-locking effect and a better cooling effect.

[0061] In some preferred embodiments, the evaluation of transepidermal water loss rate includes: measuring the transepidermal water loss rate of facial skin using a transepidermal water loss test device. The lower the value of the transepidermal water loss rate, the better the skin barrier, indicating that the product has a better water-locking effect and a better cooling effect of the product.

[0062] In the present invention, after using the daily chemical product, the smaller the pore area is, the better the effect of the product in improving pores is, and the better the cooling effect of the product is.

[0063] In some preferred embodiments, the evaluation of pore area includes: collecting skin images using a facial image analyzer, and analyzing the facial pore area using image analysis software. The smaller the pore area, the better the effect of the product in improving pores, and the better the cooling effect of the product.

[0064] In the present invention, after using the daily chemical product, the fewer the number of pores, the better the effect of the product in improving pores, and the better the cooling effect of the product.

[0065] In some preferred embodiments, the evaluation of the number of pores includes: collecting skin images using a facial image analyzer, and analyzing the number of facial pores using image analysis software. The fewer the number of pores, the better the effect of the product in improving pores, and the better the cooling effect of the product.

[0066] In the present invention, after using the daily chemical product, the fewer the number of porphyrins in the skin, the better the improvement effect of the product on subcutaneous fat, and the more obvious the cooling effect of the product.

[0067] In some preferred embodiments, the evaluation of porphyrin includes: collecting skin images using a facial image analyzer, and analyzing the porphyrins in the subcutaneous layer using image analysis software. The fewer the porphyrins, the better the product's effect on improving subcutaneous fat, and the more obvious the cooling effect of the product.

[0068] In some preferred embodiments, the method for evaluating the cooling effect of daily chemical products further comprises the following steps: evaluating the level of the cooling effect according to the number of first parameters with significant differences in results and the number of second parameters with significant differences in results.

[0069] In some more preferred embodiments, the judgment criteria for the cooling effect include: on the premise that the result difference of at least one parameter in the first parameter is significant, if the result difference of one parameter in the first parameter is significant, it is level I; if the result difference of two parameters in the first parameter is significant, it is level II; if the result difference of three parameters in the first parameter is significant, it is level III; if the result difference of four parameters in the first parameter is significant, it is level IV; if there is no significant difference in the second parameters, there is no mark; if the result difference of one parameter in the second parameter is significant, a "+" sign is marked after the level symbol; if the result difference of two parameters in the second parameter is significant, two "++" signs are marked after the level symbol; on the premise that the result difference in the first parameter is not significant, if the result difference of one parameter in the second parameter is significant, a "+" sign is marked; if the result difference of two parameters in the second parameter is significant, two "++" signs are marked.

[0070] In some preferred embodiments, the method for evaluating the cooling effect of daily chemical products further comprises the following steps: before collecting evaluation parameter information, preselecting appropriate evaluation parameters according to the formula information of the daily chemical products to be tested.

[0071] In some preferred embodiments, the daily chemical product cool effect evaluation method further comprises the following steps: using a computer to process the parameter information of the daily chemical product collected, calculated and evaluated, so as to predict the cool effect according to the formula information of the daily chemical product to be tested. In some more preferred embodiments, the daily chemical product cool effect evaluation method further comprises the following steps: using an artificial intelligence method to process the parameter information of the daily chemical product collected, calculated and evaluated, so as to predict the cool effect according to the formula information of the daily chemical product to be tested. In the present invention, the artificial intelligence method includes at least one of the current main machine learning, deep learning, natural language processing, computer vision and expert system.

[0072] A second aspect of the present invention provides a device for evaluating the cooling effect of daily chemical products, the device comprising:

[0073] A collection module, used to collect evaluation parameter information of the subject before and after using the daily chemical product;

[0074] A calculation module, used for calculating the results of the evaluation parameter information before and after using the daily chemical product;

[0075] An evaluation module is used to evaluate the cooling effect of the daily chemical product according to the result calculated by the calculation module.

[0076] In some preferred embodiments, the cooling effect evaluation device for daily chemical products further comprises: an evaluation parameter preselection module for preselecting appropriate evaluation parameters according to the formula information of the daily chemical product to be tested before collecting the evaluation parameter information.

[0077] In some preferred embodiments, the cooling effect evaluation device for daily chemical products also includes an artificial intelligence information processing module for learning and analyzing parameter information of daily chemical products that have been collected, calculated and evaluated, so as to predict the cooling effect based on the formula information of the daily chemical products to be tested.

[0078] In some preferred embodiments, the cooling effect evaluation device for daily chemical products further comprises a subject screening module for including subjects meeting the inclusion criteria and excluding subjects meeting the exclusion criteria.

[0079] The subject screening module includes:

[0080] A subject screening unit is used to screen out subjects who meet the inclusion criteria;

[0081] The subject exclusion unit excludes subjects who do not meet the requirements according to the subject exclusion criteria;

[0082] The subject recording unit is connected to the subject screening unit and records the subjects who meet the selection criteria.

[0083] In some preferred embodiments, the inclusion criteria include at least one of the following a1-a8:

[0084] a1. Aged between 18 and 60, healthy and without history of serious illness;

[0085] a2. Volunteers have no obvious skin lesions, inflammation, eczema, etc. at the test site;

[0086] a3. Those without severe systemic diseases, immunodeficiency or autoimmune diseases;

[0087] a4. The tested area has not been subjected to skin treatment, cosmetic treatment or other tests that may affect the results;

[0088] a5. Those without active allergic diseases;

[0089] a6. Those who have not participated in other clinical trials in the past month;

[0090] a7. Those without highly sensitive constitution;

[0091] a8. Those who have not used hormone drugs or immunosuppressants in the past month;

[0092] In some preferred embodiments, the exclusion criteria include at least one of the following b1-b7:

[0093] b1. Pregnant or breastfeeding women (for female volunteers);

[0094] b2. Both arms have dermatitis, scars or severe folliculitis and other diseases that may affect the test results;

[0095] b3. Have the habit of taking medicines for a long time, such as aspirin, medicines containing aspirin, anti-inflammatory drugs, anti-allergic drugs, adrenocortical steroids, beta-blockers (including eye drops), and desensitization drugs;

[0096] b4. In the past 6 months, the patient has been hospitalized or consulted by the researcher for the following diseases: cardiopulmonary, digestive system, nervous system, mental illness, gynecological disease, urinary system, blood or endocrine disease (especially insulin-dependent diabetes mellitus);

[0097] b5. Received antihistamine or allergy medication in the past week;

[0098] b6. Have received any vaccination in the past month or plan to receive any vaccination during the study;

[0099] b7. Those who cannot cooperate with the experiment.

[0100] The third aspect of the present invention provides an electronic system, comprising: a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein when the processor executes the program, the method for evaluating the cooling effect of daily chemical products as described above is implemented.

[0101] A fourth aspect of the present invention provides a computer-readable storage medium storing computer-executable instructions for causing a computer to execute the above-mentioned method for evaluating the cooling effect of daily chemical products.

[0102] In the description of the present invention, the description with reference to the terms "one embodiment", "some embodiments", "an example", "specific embodiment" or "example" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or embodiment or example are included in at least one embodiment or embodiment or example of the present application. In this specification, the above terms are schematic expressions and are not necessarily for the same embodiment or embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine different embodiments or embodiments or examples described in this specification and the features of different embodiments or embodiments or examples, without contradiction.

[0103] Any process or method description described in the flowchart of the present invention or otherwise in this specification may be understood to represent a module, fragment or portion of a code including one or more executable instructions for implementing the steps of a specific logical function or process, and the scope of the preferred embodiments of the present application includes alternative implementations, in which functions may not be performed in the order shown or discussed, including performing functions in a substantially simultaneous manner or in the reverse order depending on the functions involved, which should be understood by technicians in the technical field to which the embodiments of the present application belong.

[0104] The logic and / or steps represented in the flowchart or described in other ways in this specification, for example, can be considered as an ordered list of executable instructions for implementing logical functions, and can be specifically implemented in any computer-readable storage medium for use by an instruction execution system, device or equipment (such as a computer-based system, a system including a processor, or other system that can fetch instructions from an instruction execution system, device or equipment and execute instructions), or in combination with these instruction execution systems, devices or equipment. For the purpose of this specification, a computer-readable storage medium can be any device that can contain, store, communicate, propagate or transmit a program for use by an instruction execution system, device or equipment or in combination with these instruction execution systems, devices or equipment. In practical applications, the computer-readable storage medium can adopt any combination of one or more computer-readable media. The computer-readable medium can be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of computer-readable storage media (a non-exhaustive list) include: an electrical connection with one or more conductors, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above. In this embodiment, a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

[0105] It should be understood that the various parts of the present application can be implemented by hardware, software, firmware or a combination thereof. In the above-mentioned embodiments, multiple steps or methods can be implemented by software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if implemented by hardware, as in another embodiment, it can be implemented by any one of the following technologies known in the art or their combination: a discrete logic circuit having a logic gate circuit for implementing a logic function for a data signal, a dedicated integrated circuit having a suitable combination of logic gate circuits, a programmable gate array (PGA), a field programmable gate array (FPGA), etc.

[0106] A person of ordinary skill in the art can understand that all or part of the steps carried by the method for implementing the above-mentioned implementation mode or embodiment can be completed by instructing the relevant hardware through a program, and the program can be stored in a computer-readable storage medium, and the program, when executed, includes one or a combination of the steps of the method embodiment. In addition, each functional unit in each implementation mode or embodiment of the present application can be integrated in a processing module, or each unit can exist physically separately, or two or more units can be integrated in one module. The above-mentioned integrated module can be implemented in the form of hardware or in the form of a software functional module. If the integrated module is implemented in the form of a software functional module and sold or used as an independent product, it can also be stored in a computer-readable storage medium. The above-mentioned storage medium can be a read-only memory, a disk or an optical disk, etc.

[0107] Obviously, the implementation modes or examples of the present invention are merely examples for clearly illustrating the present invention, and are not limitations of the present invention. For ordinary technicians in the relevant field, other different forms of changes or modifications can be made on the basis of the above description. It is impossible to list all the implementation modes or examples here. All obvious changes or modifications derived from the technical solution of the present invention are still within the scope of protection of the present invention.

[0108] Example

[0109] In order to make the purpose, technical scheme and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and examples. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. The experimental methods in the following examples that do not specify specific conditions are usually tested under conventional conditions or under conditions recommended by the manufacturer.

[0110] The endpoints and any values ​​of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this article.

[0111] In the following embodiments, the following contents need to be explained:

[0112] Subject requirements

[0113] Inclusion criteria:

[0114] a1. Aged between 18 and 60, healthy and without history of serious illness;

[0115] a2. Volunteers have no obvious skin lesions, inflammation, eczema, etc. at the test site;

[0116] a3. Those without severe systemic diseases, immunodeficiency or autoimmune diseases;

[0117] a4. The tested area has not been subjected to skin treatment, cosmetic treatment or other tests that may affect the results;

[0118] a5. Those without active allergic diseases;

[0119] a6. Those who have not participated in other clinical trials in the past month;

[0120] a7. Those who are not highly sensitive; and

[0121] a8. Those who have not used hormone drugs or immunosuppressants in the past month;

[0122] Exclusion criteria:

[0123] b1. Pregnant or breastfeeding women (for female volunteers);

[0124] b2. Both arms have dermatitis, scars or severe folliculitis and other diseases that may affect the test results;

[0125] b3. Have the habit of taking medicines for a long time, such as aspirin, medicines containing aspirin, anti-inflammatory drugs, anti-allergic drugs, adrenocortical steroids, beta-blockers (including eye drops), and desensitization drugs;

[0126] b4. In the past 6 months, the patient has been hospitalized or consulted by the researcher for the following diseases: cardiopulmonary, digestive system, nervous system, mental illness, gynecological disease, urinary system, blood or endocrine disease (especially insulin-dependent diabetes mellitus);

[0127] b5. Received antihistamine or allergy medication in the past week;

[0128] b6. Have received any vaccination in the past month or plan to receive any vaccination during the study; and

[0129] b7. Those who cannot cooperate with the experiment.

[0130] Evaluation methods include:

[0131] Subject determination: Screen and select suitable subjects. Inclusion criteria: Subjects are willing to participate and can cooperate with the test. Exclusion criteria: Pregnant or lactating women, those with severe systemic diseases, immunodeficiency or autoimmune diseases, or those with active allergic diseases / highly allergic constitutions, those who have received skin treatment, cosmetic surgery, or have wounds or wounds on the test site are not suitable for the test.

[0132] Collect the evaluation parameter information of the subject's skin: including the skin index data and skin image data measured by the non-invasive skin index test instrument covering multiple skin indexes of each subject, as well as the subject's skin feeling self-evaluation data. The evaluation parameter information collected by the test instrument includes: the first parameter (TiVi value, redness value, transepidermal water loss rate, pore area) and the second parameter (number of pores, porphyrin).

[0133] The evaluation of skin TiVi value includes: using a skin sensitivity tester to collect skin images and analyzing the skin TiVi value; the smaller the skin TiVi value, the slower the subcutaneous blood flow rate and the more obvious the cooling effect of the product.

[0134] The evaluation of skin redness value includes: using Antera 3D CS multifunctional skin imaging analyzer to collect skin images and analyze the skin redness value. The lower the skin temperature, the lighter the red color displayed in the image. The product has a better cooling effect.

[0135] The evaluation of transepidermal water loss rate includes: using transepidermal water loss testing equipment to measure the transepidermal water loss rate of facial skin. The lower the value, the better the skin barrier, which indicates that the product's water-locking effect is better and the product's cooling effect is better.

[0136] The evaluation of pore area includes: using a facial image analyzer to collect skin images, and using image analysis software to analyze the facial pore area. The smaller the pore area, the better the product's effect in improving pores, and the better the product's cooling effect.

[0137] The evaluation of the number of pores includes: using a facial image analyzer to collect skin images, and using image analysis software to analyze the number of facial pores. The fewer the number of pores, the better the effect of the product in improving pores, and the better the cooling effect of the product.

[0138] The evaluation of porphyrin includes: using a facial image analyzer to collect skin images, and using image analysis software to analyze the porphyrins in the subcutaneous layer of the skin. The fewer the number, the better the product's effect on improving subcutaneous oil, and the more obvious the product's cooling effect.

[0139] In the following embodiments, the above 6 parameters are collected and evaluated by TiVi7002.0 skin sensitivity tester, VapoMeter transepidermal water loss meter and VISIA-CR facial image analyzer, Antera 3D CS multifunctional 3D skin imaging analyzer professional image analysis equipment and matching analysis software, and are calculated, processed and analyzed.

[0140] Test design: Select the sample parameters collected according to the type, characteristics and mechanism of action of the test sample (select at least one first parameter as the product cooling effect determination index, the first parameter is referred to the content of the instructions). The subjects cannot apply any product to the test area on the day of the test, and rest for 30 minutes in a constant temperature and humidity environment (21±1)℃ and relative humidity (50±5)%. After that, the subject's skin is heat-treated (temperature 30℃-33℃, humidity 65%-70%). The heat treatment method includes but is not limited to outdoor sports warm-up (outdoor environment temperature 30℃-39℃, humidity 65%-70%), infrared heater irradiation (to make the skin surface temperature reach 40±2℃), etc. The subjects are tested immediately after the heat treatment (before using the product) and at any time point after using the product (including but not limited to immediately, 10min, 30min, etc.), and the test area position of each subject is consistent each time.

[0141] Evaluation process:

[0142] 1. After the subject cleans the skin of the evaluation area, the skin surface of the evaluation area is placed in a hot state through heat treatment;

[0143] 3. Use VISIA-CR / Antera 3D / skin sensitivity tester and other image acquisition equipment to take pictures of the evaluation area, and use a skin probe to measure and record the transepidermal water loss rate of the evaluation area of ​​the subject;

[0144] 3. The researcher guides the subjects to use the evaluation product according to the design of the research plan;

[0145] 4. Repeat step 3 after T10min and T30min after use.

[0146] Sample usage requirements

[0147] 1. The amount of product used should take into account factors such as product characteristics, usage location, and frequency of use;

[0148] 2. The dosage of the product is usually: Facial products: 2mL-5mL for the whole face; Body products: (2.0±0.1)mg / cm 2 .

[0149] Data analysis: SAS, SPSS, EXCEL and other special statistical software were used for statistics, and t or rank sum test was used (if the data were normally distributed, t test was used for data analysis and statistics; if the data were non-normally distributed, rank sum test was used for statistics).

[0150] Example 1 Verification of Cooling Effect Evaluation Parameters

[0151] Test 1: Simulating cool feeling conditions, skin heat treatment (skin surface temperature reaches 40±2℃) - Effect of cold environment (21±1℃, 50±10%RH) on TiVi value

[0152] Test steps: The inner forearms of 6 subjects were heat-treated, and then they sat quietly in a cold environment for at least 30 minutes. At two points after the heat treatment and after the quiet sitting, the skin sensitivity tester TiVi7002.0 was used to take photos and measure the skin TiVi value.

[0153] Data analysis: SAS, SPSS, EXCEL and other special statistical software were used for statistics, and t or rank sum test was used (if the data were normally distributed, t test was used for data analysis and statistics; if the data were non-normally distributed, rank sum test was used for statistics).

[0154] Test results: Under the simulated cool feeling condition, when the skin is changed from heat treatment to cold environment for 30 minutes, the skin TiVi value shows a significant downward trend as the skin temperature decreases. See Table 1 for details. Figure 2 .

[0155]

[0156] Conclusion: Experiment 1 used the skin sensitivity tester TiVi7002.0 to collect skin images, and used the instrument's supporting software to analyze the skin's TiVi value. The instrument's working principle is to use the characteristics of red blood cells in blood vessels to absorb green light to obtain the distribution and aggregation images of red blood cells in skin tissue. The results can reflect the reaction and changes of the subcutaneous microvessels of the skin. When the skin is under hot conditions, the subcutaneous blood flow speeds up and the skin's TiVi value increases; conversely, the smaller the skin's TiVi value, the slower the subcutaneous blood flow speed, and the more obvious the product's cooling effect.

[0157] Test 2: Effect of simulated coolness conditions (hot environment (33±1℃, 60±10%RH)-cold environment (21±1℃, 50±10%RH) on skin redness value

[0158] Test steps: 6 subjects sit in a hot environment and a cold environment for at least 30 minutes respectively. They are not allowed to go out during the test. Then photos are taken to measure the skin redness value.

[0159] Data analysis: SAS, SPSS, EXCEL and other special statistical software were used for statistics, and t or rank sum test was used (if the data was normally distributed, t test method was used for data analysis and statistics; if the data was non-normally distributed, rank sum test method was used for statistics). p < 0.05 indicated that the difference was significant.

[0160] Test results: Under the simulated cool feeling condition, the skin redness value shows a significant downward trend as the skin temperature decreases from a hot environment to a cold environment, as shown in Table 2. Figure 2 .

[0161]

[0162] Test 3: The effects of simulated cooling conditions (making the face in a high-heat state (38±1℃) after outdoor exercise) - immediately lowering the facial temperature (29±1℃)) on the four evaluation parameters of skin transepidermal water loss rate, pore area, number of pores, and porphyrin.

[0163] Test steps: Select 6 subjects, wash their faces with clean water 1 hour before the measurement, then exercise outdoors for half an hour to keep their faces in a high-heat state; immediately after the exercise, take facial images, use a skin probe to measure and record the transepidermal water loss rate of the volunteers (hot state); immediately after the measurement, wrap ice cubes with frozen facial tissue and place them close to the skin beside the nose to cool it down, take photos and measure after cooling for 5 minutes, and record the skin data (cold state). The above skin parameters are obtained through professional instrument measurement, professional image analysis equipment and corresponding supporting analysis software.

[0164] Data analysis: SAS, SPSS, EXCEL and other special statistical software were used for statistics, and t or rank sum test was used (if the data was normally distributed, t test method was used for data analysis and statistics; if the data was non-normally distributed, rank sum test method was used for statistics). p < 0.05 indicated that the difference was significant.

[0165] Test results: Under the simulated cooling condition, when the skin goes from a high temperature state to an immediate cooling state, the skin transepidermal water loss rate, pore area, number of pores, and porphyrins show a significant downward trend as the skin temperature decreases, and there are significant differences in transepidermal water loss rate and pore area. See Table 3-Table 6 for details. Figure 2 .

[0166]

[0167]

[0168] Conclusion: Thermal stimulation can lead to sensitive reactions such as redness, capillary dilation, decreased skin barrier function, enlarged pores, and more oil secretion by sebaceous glands. Experiments 2 and 3 simulated cool conditions to verify the effect of temperature on five skin parameters: skin redness, transepidermal water loss, pore area, number of pores, and porphyrin. That is, the values ​​of the above five parameters decreased as the skin temperature decreased.

[0169] The three experiments in Example 1 above prove that the six skin parameters of skin TiVi value, redness value, transepidermal water loss rate, pore area, number of pores, and porphyrin can be used as evaluation parameters for cooling effect products, and can be used as evaluation parameters for cooling effect of products. Among them, the TiVi value, redness value, transepidermal water loss rate, and pore area have significant differences in values ​​in hot and cold states, and can be used as the first parameter for determining the cooling effect of the product, while the number of pores and porphyrin can be used as the second parameter, which can be used as auxiliary indicators for determining the cooling effect.

[0170] Example 2

[0171] Based on the treatment of Experiment 1 in Example 1, the cooling effect of a mosquito repellent product containing 20-35% ethanol was evaluated using the TiVi value.

[0172] The product's cooling effect mechanism: It utilizes the volatility of ethanol to absorb heat through evaporation to create a cooling effect.

[0173] Selection of evaluation parameters: According to the product type and mechanism of action of mosquito repellent liquid, TiVi value is selected as the evaluation parameter of the product's cool feeling; judgment basis: after use, if the change results of TiVi value at any time point are significantly different (p<0.05), it means that the product has a cool effect, otherwise it means that the product does not have a cool effect.

[0174] Test steps: Prepare the test sample mosquito repellent liquid A1 to be evaluated for cooling effect. Recruit 10 subjects and apply the test sample A1 once quantitatively to the test area on the flexor side of the forearm. The product application area and the blank control area should be randomly distributed in the marked areas of the left and right arms. Measure the TiVi value at multiple time points (T0, Tmin30).

[0175] Data analysis: SAS, SPSS, EXCEL and other special statistical software were used for statistics, and t or rank sum test was used (if the data were normally distributed, t test was used for data analysis and statistics; if the data were non-normally distributed, rank sum test was used for statistics).

[0176] Test results: Intra-group comparison: Compared with the baseline value T0, the TiVi value of the A1 sample group showed a downward trend at 30 minutes, changing by -3.64%, with a significant difference (P<0.05); the TiVi value of the blank control group showed an upward trend at 30 minutes, changing by 5.31%, with a significant difference (P<0.05). Inter-group comparison: The TiVi value of the sample group at the measurement time point was significantly different from that of the blank group (P<0.05), as shown in Table 7, Figure 3 The TiVi images of the subjects before and after using the mosquito repellent are shown below. Figure 7 shown.

[0177]

[0178] Conclusion: Through the human body cooling test of Example 2, after using the test sample A1, the subcutaneous blood flow velocity of the human skin has a significant change within 30 minutes. The mosquito repellent A1 can continuously provide a cooling sensation to the skin within 30 minutes.

[0179] Example 3

[0180] Evaluation of the cooling effect of a gel product containing 1-5% Albizia Julibrissin flower extract and Gastrodia elata root extract based on the skin parameters in Tests 2 and 3 of Example 1

[0181] Product cooling mechanism: Gel-type products can utilize the high specific heat capacity of water to achieve a cooling effect and prolong the cooling time.

[0182] Selection of evaluation parameters: Based on the product type and mechanism of action, redness value, transepidermal water loss rate, pore area, number of pores, and porphyrin are selected as product cooling evaluation parameters; Judgment basis: At any time point, if the change results of at least one of the main parameters (redness value, transepidermal water loss rate, pore area) are significantly different (p < 0.05), it means that the product has a cooling effect, otherwise it means that the product does not have a cooling effect.

[0183] Test steps: Prepare the test sample gel A2 to be evaluated for cooling effect. Recruit 5 subjects, and after appropriate heat treatment of the subjects' skin, apply the test sample A2 and the negative control quantitatively and randomly on the left and right cheeks. At multiple time points (T0, Tmin10, Tmin30), use professional instruments and professional image analysis equipment to measure the redness value, transepidermal water loss, pore area, number of pores, and porphyrin.

[0184] Data analysis: SAS, SPSS, EXCEL and other special statistical software were used for statistics, and t or rank sum test was used (if the data were normally distributed, t test was used for data analysis and statistics; if the data were non-normally distributed, rank sum test was used for statistics).

[0185] Test results: Intra-group comparison: Compared with the baseline value T0, the transepidermal water loss rate of the A2 sample group showed a downward trend at 10 minutes, changing by -16.42%, with significant differences (P<0.05); the skin redness value, transepidermal water loss rate, and pore area showed a downward trend at 30 minutes, changing by -6.59%, -14.37%, and -6.56%, respectively, with significant differences (P<0.05). Inter-group comparison: The pore area and number of pores in the sample group at the measurement time point of 10 minutes were significantly different from those in the negative control group (P<0.05), as shown in Tables 8-12, see Figure 4 The redness value images of the subjects before and after using the gel product are as follows: Figure 8 shown.

[0186]

[0187]

[0188]

[0189] Conclusion: Through the human body cooling test of Example 3, after using the test sample A2, the human skin redness value, transepidermal water loss rate, and pore area have significant changes within 30 minutes. Gel A2 can continuously provide a cooling sensation to the skin within 30 minutes.

[0190] Example 4

[0191] Evaluation of the cooling effect of an essence water product containing 5-10% polyol and 3.8%-5% medicinal porphyra extract based on the skin parameters in Experiments 2 and 3 of Example 1

[0192] Product cooling mechanism: This essence water can absorb heat from the skin surface by evaporation, creating a cooling effect.

[0193] Selection of evaluation parameters: Based on the product type and mechanism of action, redness value, transepidermal water loss rate, pore area and porphyrin are selected as product cooling evaluation parameters. At any time point, if the change results of at least one of the main parameters (redness value, transepidermal water loss rate, pore area) are significantly different (p<0.05), it means that the product has a cooling effect; otherwise, it means that the product does not have a cooling effect.

[0194] Test steps: Prepare the test sample essence water A3 to be evaluated for cooling effect. Recruit 5 subjects, and after appropriate heat treatment of the subjects' skin, apply the test sample A3 and the blank control quantitatively and randomly on the left and right cheeks. At multiple time points (T0, Tmin10, Tmin30), use professional instrument measurement and professional image analysis equipment to measure the redness value, transepidermal water loss rate, pore area, and porphyrin.

[0195] Data analysis: SAS, SPSS, EXCEL and other special statistical software were used for statistics, and t or rank sum test was used (if the data were normally distributed, t test was used for data analysis and statistics; if the data were non-normally distributed, rank sum test was used for statistics).

[0196] Test results: Intra-group comparison: Compared with the baseline value T0, the skin redness value of the A3 sample group showed a downward trend at 10 minutes, changing by -7.71%, with a significant difference (P<0.05). Inter-group comparison: The porphyrin in the sample group at the measurement time point of 10 minutes was significantly different from that in the blank control group (P<0.05), as shown in Tables 13-17, Figure 5 The pores of the subjects before and after using the essence water are as follows Figure 6 shown.

[0197]

[0198]

[0199]

[0200] Conclusion: Through the human body cooling test of Example 4, after using the test sample A3, the redness value of human skin has a significant change within 10 minutes. Essence water A3 can continuously provide a cooling feeling to the skin within 10 minutes.

[0201] The above Examples 2, 3 and 4 prove that by using a non-invasive skin instrument to measure six evaluation parameters, namely, skin TiVi value, redness value, transepidermal water loss rate, pore area, number of pores and porphyrin, the six evaluation parameters can be applied to the evaluation of the cooling effect of daily chemical products. This can make an objective evaluation of the cooling effect of daily chemical products in a more objective, scientific and comprehensive manner, and is suitable for promotion and application in the evaluation of the cooling effect of any daily chemical products that come into contact with the skin.

[0202] The specific implementation methods of the present invention are described in detail above. Although some embodiments have been shown and described, those skilled in the art should understand that these embodiments can be modified and improved without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents. These modifications and improvements should also be within the scope of protection of the present invention.

[0203] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention and do not constitute a limitation on the content of the present invention. Within the technical concept of the present invention, the technical solution of the present invention can be subjected to a variety of simple modifications, including the combination of various technical features in any other suitable manner, and these simple modifications and combinations should also be regarded as the contents disclosed by the present invention and belong to the protection scope of the present invention.

Claims

1. A method for evaluating the cooling effect of daily chemical products, characterized in that: The following steps are involved: (1) collecting evaluation parameter information of the subjects before and after using the daily chemical products; The evaluation parameters include a first parameter and an optional second parameter; the first parameter includes at least one of a TiVi value, a redness value, a transepidermal water loss rate and a pore area; the second parameter includes the number of pores and / or porphyrin; (2) calculating the results of the evaluation parameter information before and after using the daily chemical product; (3) Analyze and evaluate the cooling effect of daily chemical products based on the results: If the result of at least one evaluation parameter at any time point is statistically significantly different before and after using the daily chemical product or compared with the negative / blank control, it means that the product has a cooling effect; otherwise, it means that the product does not have a cooling effect.

2. The method for evaluating the cooling effect of daily chemical products according to claim 1, characterized in that: In step (1), the evaluation parameter information includes skin physiological or biochemical data information or image information.

3. The method for evaluating the cooling effect of daily chemical products according to claim 2, characterized in that: In step (3), if the result of at least one first parameter at any time point is significantly different before and after using the daily chemical product or compared with the negative / blank control, that is, when p<0.05, it means that the product has a cooling effect; otherwise, it means that the product does not have a cooling effect; If the results of the first parameters are not significantly different, then if the results of at least one second parameter are significantly different at any time point compared with before and after using the daily chemical product or compared with the negative / blank control, that is, when p<0.05, it means that it has a cooling effect, otherwise it means that it does not have a cooling effect.

4. The method for evaluating the cooling effect of daily chemical products according to claim 1, characterized in that: The following steps are also included: Before collecting the evaluation parameter information, preselect appropriate evaluation parameters according to the formula information of the daily chemical product to be tested; and / or use a computer to process the parameter information of the daily chemical product that has been collected, calculated and evaluated, so as to predict the cooling effect according to the formula information of the daily chemical product to be tested.

5. The method for evaluating the cooling effect of daily chemical products according to claim 1, characterized in that: The daily chemical products include at least one of cosmetic products, disinfectant products, mechanical products, special products and pesticide products.

6. A cooling effect evaluation device for daily chemical products, characterized in that: The device comprises: A collection module, used to collect evaluation parameter information of the subject before and after using the daily chemical product; A calculation module, used for calculating the results of the evaluation parameter information before and after using the daily chemical product; An evaluation module is used to analyze and evaluate the cooling effect of the daily chemical product according to the result calculated by the calculation module.

7. The cooling effect evaluation device for daily chemical products according to claim 6, characterized in that: The device also includes: An evaluation parameter preselection module is used to preselect appropriate evaluation parameters according to the formula information of the daily chemical product to be tested before collecting the evaluation parameter information; and / or The data sharing module is used to provide evaluation parameter information through a computer network.

8. The cooling effect evaluation device for daily chemical products according to claim 6, characterized in that: The device also includes an artificial intelligence information processing module for learning and analyzing parameter information of daily chemical products that have been collected, calculated and evaluated, so as to predict the cooling effect according to the formula information of the daily chemical products to be tested.

9. An electronic system comprising: A memory, a processor, and a computer program stored in the memory and executable on the processor, wherein when the processor executes the program, the method for evaluating the cooling effect of daily chemical products as described in any one of claims 1 to 5 is implemented.

10. A computer-readable storage medium storing computer-executable instructions, characterized in that: The computer executable instructions are used to enable a computer to execute the cooling effect evaluation method for daily chemical products as described in any one of claims 1 to 5.

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