Portable dry biochemical analyzer and use method thereof

Abstract

The invention discloses a portable dry-type biochemical analyzer and a use method, and belongs to the technical field of blood biochemical detection.The biochemical analyzer mainly comprises a machine shell, a chip interface module, a pressurization module, a scanning light detection module, a control and calculation unit and a power module. The biochemical analyzer disclosed by the invention is a detection host with a small structure, realizes in-situ high-efficiency filter pressing of trace blood on the detection chip, obtains serum, performs microfluidic separation, enters a detection point of the detection chip to react with a drying reagent, and performs detection on the detection point of the detection chip. A micro multi-band integrated light source arranged on the detection host is used for optical joint detection, rapid and convenient biochemical detection is realized, meanwhile, the accuracy of blood biochemical detection is greatly improved, and the biochemical detection device is small in size, small in quantity demand of detected blood, short in detection time, low in detection cost and not limited by use places and environments.

Description

Technical Field

[0001] The present application belongs to the field of medical technology, and specifically to the field of blood biochemical detection technology. Background Art

[0002] The existing biochemical detection devices in the prior art have the following problems: large size, large amount of blood required for detection, long detection time, high detection cost, and limited location and environment for use of biochemical detection devices; On the one hand, it is not easy to achieve miniaturization and precision requirements for light source solutions used in biochemical detection. In particular, the miniaturization and integration of light sources in multiple frequency bands is more difficult and cannot effectively guarantee precision, which is not conducive to the convenience and accuracy of detection. On the other hand, general blood biochemical tests require the use of centrifugation technology to exclude blood cells to obtain serum and avoid the interference of blood cells in biochemical tests. The use of this centrifugation technology inevitably limits the miniaturization and convenience of blood biochemical tests. There are also the difficulties in the precision microfluidics technology in miniaturization and the precision optical inspection micro-integration innovation; However, the demand for blood biochemical testing, especially miniaturization and convenience, is becoming more and more prominent. The difficulty of miniaturization and convenience of blood biochemical testing lies in the difficulty of integrating and innovating the testing methods and testing systems. Therefore, there is an urgent need to research and develop ways to overcome the difficulties in micro-integration of blood biochemical testing and provide micro-convenient, fast and accurate blood biochemical testing solutions. Summary of the invention

[0003] The present application discloses a portable dry biochemical analyzer and a method of use, which are used to solve the difficulties in the background technology related to the current micro-integration of blood biochemical detection, and provide a micro-convenient, fast and accurate blood biochemical detection solution.

[0004] According to one aspect of the present application, the present application discloses a portable dry biochemical analyzer, comprising an analyzer; The analyzer is used in conjunction with a detection chip for convenient dry biochemical detection of trace amounts of blood; the detection chip is configured with a filter press cavity, sequence points, a microchannel, a detection point cavity, and a drying reagent; The analyzer includes a housing, which may be a small structure for accommodating various components of the analyzer; A chip interface module is arranged on one side of the housing, and is used for plugging and identifying the detection chip dripped with a trace amount of blood, and for temperature control of the detection chip; The pressurizing module is used to precisely drive the trace amount of blood in the detection chip to pass through the filter element in the filter cavity, and the serum obtained by filtration flows into all the detection point cavities of the sequence points through the microchannels one by one until the serum is filled with the dried reagents corresponding to the detection point cavities of the sequence points, so that the serum can fully react with the dried reagents corresponding to the detection point cavities of the sequence points, and then all the detection point cavities corresponding to the sequence points are kept full and fully reacted and wait for detection; A scanning optical inspection module is used to precisely drive the detection light of the micro multi-frequency optical module to perform corresponding optical scanning and penetration inspection on the sequence points of the detection chip waiting for detection, so as to obtain the multi-link optical detection information of the detection chip; A control and calculation unit, used for coordinating control and performing analysis and calculation based on the obtained multi-link optical detection information of the detection chip, to obtain and output the detection result corresponding to the detection chip; and a power module for supplying power.

[0005] Preferably, the filter press cavity forms an inlet on the upper surface of the detection chip, and a trace amount of blood drips into the filter press cavity of the detection chip through the inlet; The filter press cavity is provided with a filter press element for filtering blood cells to obtain serum; the sequence points include multiple detection points; the detection points are formed with detection point cavities in the detection chip; the detection point cavities are connected to the filter press cavity through microchannels in a one-to-one correspondence; the sequence points are configured with corresponding drying reagents in the corresponding detection point cavities.

[0006] Preferably, the chip interface module includes a crossbeam, an identity recognition module and a temperature control unit; The side of the housing is provided with a socket, the crossbeam is arranged on one side of the housing close to the socket, and both ends are fixed in the housing; The crossbeam is provided with a mating groove corresponding to the socket at the middle position along the length direction; One end of the detection chip can pass through the socket of the housing and be plugged into the plug-in slot of the beam; The detection chip is provided with an identity module; The identity recognition module corresponds to the identity module of the detection chip and is arranged on the housing, and cooperates with the identity module to identify the ID information of the detection chip; The mating slot is provided with a pressurized opening and an optical inspection opening on the upper side of the crossbeam; the optical inspection opening extends downward and penetrates the crossbeam to form an optical inspection slot; when the detection chip is plugged into the mating slot, the pressurized opening corresponds to the sample inlet of the detection chip; the optical inspection slot corresponds to the sequence point of the detection chip; The temperature control unit includes a heating plate and a temperature sensor, which are built into the bottom of the plug-in slot of the crossbeam. When the detection chip is plugged into the plug-in slot, the heating plate and the temperature sensor abut against the detection chip.

[0007] Preferably, the ID information of the detection chip includes the type of the detection chip and the information of the desiccated reagent built into the detection chip, and the detection chip has at least 7 types, and the corresponding detection types are liver function detection, kidney function detection, virus infection detection, glycolipid detection, pancreas detection, kidney glycolipid detection and myocardial detection; Each type of detection chip corresponds to a plurality of detection items, each detection item corresponds to at least one detection point, and corresponds to at least one dried reagent; the dried reagent information includes the type of dried reagent and a calibration curve.

[0008] Preferably, when the detection chip is plugged into the chip interface module and the detection chip is below a preset temperature, the heating plate performs pulse heating on the detection chip so that the detection chip is quickly heated to a pre-determined temperature range.

[0009] In an exemplary embodiment, the notch of the mating slot is provided with a guiding arc; a positioning protrusion is provided in the mating slot corresponding to the front end of the detection chip, and a positioning groove is provided at the front end of the detection chip corresponding to the positioning protrusion. The positioning groove is a semicircular notch, and the positioning protrusion is a cylinder; the positioning protrusion and the positioning slot are both provided with two and are asymmetrically designed.

[0010] Preferably, the pressurizing module comprises an elastic pressing bowl and an inclined arm lever type inclined arm lever type pressing unit for precisely pressing the elastic pressing bowl; the elastic pressing bowl is arranged above the pressurizing opening; The inclined arm lever-type lifting and pressing unit drives the elastic pressure bowl located above the pressurized opening to move downward. After passing through the pressurized opening and abutting the sampling port wrapped around the detection chip, the elastic pressure bowl is precisely lifted and elastically deformed, squeezing the air between the elastic pressure bowl and the sampling port to form a driving air pressure. The driving air pressure pushes the trace amount of blood to be filtered and micro-flown to the sequence points in the detection chip, and at the same time gradually squeezes and discharges the air in the microchannel in the detection chip and the detection point cavity corresponding to the sequence points until the serum obtained by the filtration fills all the detection point cavities of the sequence points.

[0011] Preferably, the oblique arm lever-type tilting and pressing unit is connected to the elastic pressing bowl, forming at least one pressing point on the outer side of the elastic pressing bowl; The inclined arm lever-type tilting pressure unit precisely controls the driving displacement of the pressing point, and then precisely controls the driving air pressure, and then precisely controls the rate of micro-blood filtration, the flow rate of the filtered serum in the microchannel, and the relative pressure balance state maintained after the filtered serum fills the sequence points.

[0012] Preferably, when the serum fills the sequence points, the elastic deformation of the elastic pressure bowl is reciprocatingly fine-tuned, and the driving air pressure is reciprocatingly fine-tuned, so that the serum is reciprocatingly filled in the detection point cavity, promoting a rapid and sufficient re-dissolution reaction between the serum and the dried reagent in the detection point cavity.

[0013] Preferably, the oblique arm lever type tilting and pressing unit comprises a tilting and pressing plate and a tilting and pressing fulcrum; The two sides of the tilting plate relative to the tilting fulcrum respectively form a tilting working end and a tilting driving end; The tilting and pressing working end of the tilting and pressing plate is connected to the elastic pressing bowl, and a pressing point of the elastic pressing bowl is formed at the connection; When the tilting pressure driving end is displaced relative to the tilting pressure fulcrum, the tilting pressure working end on the other side of the tilting pressure fulcrum is driven to be displaced.

[0014] Preferably, the elastic pressure bowl comprises a bowl body and a warping pressure column head, one end of the bowl body along the length direction is the outer surface of the bowl bottom, and the other end is the bowl mouth surface; The area between the outer surface of the bowl bottom and the bowl mouth is provided with an inner surface of the bowl bottom, a first bowl body section and a second bowl body section; The inner diameter and outer diameter of the bowl body between the inner surface of the bowl bottom and the first bowl body cross section gradually increase; The inner diameter and outer diameter of the bowl body gradually decrease between the first bowl body section and the second bowl body section; The inner diameter of the bowl body between the second bowl body cross section and the bowl mouth surface gradually increases, while the outer diameter first gradually increases and then gradually decreases, forming an airtight pressure interface; The warped column head is columnar; one end of the warped column head along the length direction is a fixed end, and the other end is a free end; The outer diameter of the warping column head between the free end and the fixed end gradually increases, and the fixed end is connected to the bottom surface of the bowl; An annular groove for clamping is provided in the middle of the warping column head, and both ends of the annular groove are in arc transition with the warping column head; The tilting and pressing working end is provided with a fork opening and is clamped on the annular groove through the fork opening.

[0015] Preferably, the oblique arm lever type tilting and pressing unit also includes a tilting and pressing motor installed in the casing, the tilting and pressing motor is a linear motor, the output shaft of the tilting and pressing motor is connected to the tilting and pressing driving end, and can drive the tilting and pressing driving end to produce displacement relative to the tilting and pressing fulcrum.

[0016] Preferably, the tilting pressure fulcrum is a tilting pressure shaft, which is installed in the casing through a tilting pressure bracket, and a tilting pressure travel switch is provided on the tilting pressure bracket corresponding to the tilting pressure plate, and a tilting pressure contact protrusion is provided on the tilting pressure plate corresponding to the tilting pressure travel switch.

[0017] In an exemplary embodiment, an elastic sheet is connected to the end of the tilting and pressing shaft for elastic tilting and pressing effect; the elastic sheet can be a torsion spring.

[0018] Preferably, the tilting plate is in a diamond shape; the two ends of the tilting plate along the length direction respectively form a tilting working end and a tilting driving end; the connecting line of the tilting working end and the tilting driving end obliquely intersects with the crossbeam to form an oblique arm lever; The tilting and pressing working end forms a tilting and pressing working fork adapted to the annular groove of the tilting and pressing column head; The tilting pressure driving end forms a tilting pressure driving fork adapted to the output shaft of the tilting pressure motor; The middle part of the tilting plate is provided with an axis groove for installing the tilting axis; A tilting and pressing contact convexity cooperating with the tilting and pressing travel switch is arranged on the side of the tilting and pressing plate.

[0019] In an exemplary embodiment, ribs are evenly arranged on the upper and lower sides of the tilting plate, and the ribs are arranged along the length direction of the tilting plate; the tilting working fork is a circular fork; and the tilting driving fork is a U-shaped fork.

[0020] In an exemplary embodiment, in order to ensure the filter pressing effect and make the filter pressing proceed smoothly; The filter press of the detection chip comprises a coarse filter element and a fine filter element which are arranged in sequence; the filter hole diameter of the coarse filter element is larger than that of the fine filter element; and the filtration path of the coarse filter element is much larger than that of the fine filter element.

[0021] Preferably, the optical inspection slot includes a first inspection positioning point and a sequence slot; When the detection chip is abutted and matched in the mating slot, the sequence points correspond to the sequence slots; The first detection positioning point is located at the outer side of the detection chip or on the detection chip; the detection light of the micro multi-frequency optical module can pass through the first detection positioning point without obstruction.

[0022] Preferably, the scanning optical detection module comprises a micro multi-frequency optical module, an optical detection slide rail, an optical detection slider and a scanning drive mechanism, wherein the micro multi-frequency optical module comprises a micro multi-frequency light source for selecting a detection light output of a frequency band from a plurality of frequency bands according to the frequency band; and a light receiving unit for receiving the detection light to obtain optical detection information; The optical detection slider is slidably matched on the optical detection slide rail, and the optical detection slider has a slider slot; the optical detection slot extends into the slider slot; the micro multi-frequency light source and the light receiving unit in the micro multi-frequency optical module are respectively configured on the optical detection slider corresponding to the slider slot, so that the optical detection slot is located between the micro multi-frequency light source and the light receiving unit; The scanning drive mechanism is connected to the optical inspection slider, driving the optical inspection slider to move precisely along the optical inspection slide rail, driving the micro multi-frequency optical module to optically inspect the serial points of the detection chip and the first detection positioning point one by one.

[0023] Preferably, the micro multi-frequency optical module includes a micro multi-frequency light source, which is used to selectively output at least one frequency band of detection light in a plurality of frequency bands according to the frequency band, and the detection light in the plurality of frequency bands includes the detection light in the first frequency band to the detection light in the second frequency band. Frequency band detection optical The detection light of the frequency band is is an integer greater than 1; and a light receiving unit, for receiving the detection light and obtaining optical detection information; Wherein, the micro multi-frequency light source includes a first frequency band optical element to a frequency band optical element, used to generate the first frequency band detection light to the Frequency band detection light; The micro-integrated optical path structure includes a plurality of dichroic mirrors for reflecting or transmitting a first frequency band detection light to a second frequency band detection light. frequency band detection light, shortening and conducting the first frequency band detection light to the An optical path for transmitting the frequency band detection light to the first light outlet; The first light outlet is used for the detection light of the first frequency band to The frequency band detection light is emitted out of the micro multi-frequency light source; and a collimation structure for detecting light in the first frequency band to the The frequency band detects the collimation of the light in the optical path.

[0024] Preferably, the micro multi-frequency light source further comprises a second light outlet for transmitting the first frequency band detection light to the second The micro-integrated optical path structure shortens the conduction of the first frequency band detection light to the first frequency band detection light. An optical path for transmitting detection light of at least one frequency band among the frequency band detection lights to the second light outlet.

[0025] Preferably, the micro-integrated optical path structure comprises a first dichroic mirror to a second dichroic mirror. Dichroic mirror, Wherein, the first dichroic mirror is used for reflecting the detection light of the first frequency band to the second dichroic mirror; No. Dichroic mirror, used to detect light in the first frequency band to the second 1 band detection light is transmitted to the Dichroic mirror and The frequency band detection light is reflected to the A dichroic mirror, where 1 to integer; No. Dichroic mirror, used to detect light in the first frequency band to the second The frequency band detection light is transmitted to the Dichroic mirror and The frequency band detection light is reflected to the Dichroic mirror; No. The dichroic mirror corresponds to the first light outlet and is used to detect the light from the first frequency band to the The frequency band detection light is reflected to the first light outlet, and the The frequency band detection light is transmitted to the first light outlet.

[0026] Preferably, the first to second dichroic mirrors Dichroic mirror The dichroic mirrors are stacked end to end in an alternating pattern, extending in a wave shape. The first frequency band optical element to the Frequency band optical components The optical elements are arranged alternately from the first dichroic mirror to the The side of the dichroic mirror.

[0027] Preferably, the collimating structure comprises an output lens, and the output lens is arranged between the micro-integrated optical path structure and the first light outlet.

[0028] Preferably, the collimating structure includes a first lens to a second lens. lenses, respectively arranged in the first frequency band optical element to the The side of the frequency band optical element; used to detect the first frequency band light generated corresponding to the first The frequency band detects the collimation of the light.

[0029] Preferably, the micro multi-frequency light source further comprises a power supply unit for supplying power from the first frequency band optical element to the The frequency band optical element selectively supplies single precision power and selectively outputs the first frequency band detection light to the Frequency band detection light; When the first frequency band optical element to the When the power supply parameters of any optical element of the frequency band optical element are consistent twice, the parameters of the detection light outputted by it under the same optical path are consistent; Among them, the power supply parameters include voltage and current; Parameters of the detected light include light intensity.

[0030] Preferably, the optical detection slide rail includes at least two optical detection guide rods; the optical detection slider is provided with a guide rod hole; the optical detection slider is slidably fitted on the optical detection guide rod; the scanning drive mechanism includes a driving rack, a scanning gear and a scanning motor installed in the housing; the driving rack is connected to the side of the optical detection slider away from the slider slot, and the scanning gear is connected to the output shaft of the scanning motor and meshes with the driving rack for transmission.

[0031] Preferably, the scanning optical inspection module matches at least two frequency bands of detection light to each detection point in the sequence of points for sequential transmission optical inspection; The two frequency bands of detection light include main frequency band detection light, and the main frequency band detection light can be characteristically absorbed by the product of the reaction between the built-in desiccated reagent and the serum at the corresponding detection point, and is used for characteristic absorption detection of the detection point; and a sub-band detection light, wherein the sub-band detection light cannot be characteristically absorbed by a product of a reaction between a built-in desiccated reagent and serum at a corresponding detection point, and is used for correction of characteristic absorption detection at the detection point; The main frequency band detection light and the sub-frequency band detection light are the first frequency band detection light to the second frequency band detection light. The frequency band detects two types of light.

[0032] Preferably, the light receiving unit is a light intensity detection unit, which is used to detect the light intensity of the first frequency band detection light to the Nth frequency band detection light; Using a light intensity detection unit to respectively detect the incident light intensity and the transmitted light intensity of the main frequency band detection light in the transmission light detection process; As well as the incident light intensity and transmitted light intensity of the sub-band detection light.

[0033] Preferably, when the spot diameter of the matching main-band detection light and / or sub-band detection light at the sequence point is close to the diameter of the detection point, the scanning optical detection module drives the detection light to perform transmission optical detection at the center of the detection point; When the spot diameter of the corresponding main-band detection light and / or sub-band detection light at the sequence point is smaller than the diameter of the detection point and the absolute value of the difference between the two is greater than a preset value, the scanning optical detection module drives the detection light to move within the plane range of the detection point for scanning optical detection.

[0034] Preferably, an integrated frame is provided in the housing; the integrated frame is provided with steps corresponding to the chip interface module, the scanning light detection module and the pressurizing module in sequence to form a stepped frame.

[0035] In an exemplary embodiment, a power slot for accommodating a power module is provided on one side of the integrated rack; The control and computing unit is integrated on two overlapping and plug-connected circuit boards; The other side of the integrated frame is provided with a plurality of fixing columns connected to the circuit board; The other side of the integrated frame relative to the chip interface module is provided with a fan slot for installing a heat dissipation fan; The machine compartment box or the machine compartment cover is provided with a heat dissipation window, and the heat dissipation window is provided with heat dissipation holes.

[0036] Preferably, the identity module is a QR code; the identity recognition module is a miniature camera.

[0037] Preferably, the housing includes a housing and a sliding cover; The machine compartment includes a machine compartment box and a machine compartment cover; A socket slot is provided on one side of the compartment cover; the socket is correspondingly arranged in the socket slot; The detection chip is plugged into the chip interface module and can be accommodated in the socket slot; The sliding cover is slidably matched with the top of the machine compartment cover, and can open or close the socket slot where the detection chip is inserted.

[0038] Preferably, two sliding blocks are symmetrically and parallelly arranged at the bottom of the sliding cover along its sliding direction; A slide groove is provided at one end of the top of the engine cover corresponding to the slide block; the slide block and the slide groove are slidably matched; A wire groove is provided in the middle of the engine cover, and a sliding cover in place switch is provided at the end of the wire groove away from the slide groove; The bottom of the sliding cover is provided with an in-place contact protrusion corresponding to the sliding cover in-place switch; the sliding cover is slidably matched with the top of the machine compartment cover, and the in-place contact protrusion is located in the wire groove.

[0039] Preferably, the analyzer further comprises a display and operation unit, the display and operation unit comprises a touch screen, and the touch screen is arranged on the top of the sliding cover; In an exemplary embodiment, the sliding cover includes a sliding cover body and a screen slot, a heat conducting plate and a slot bottom plate supporting the heat conducting plate are provided at the bottom of the screen slot, and a heat conducting outer frame is provided on the side of the slot bottom plate corresponding to the heat conducting plate.

[0040] On the other hand, the present application discloses a method for using the above-mentioned portable dry biochemical analyzer, comprising: step 1, sliding the slide cover to open the chip interface module; Step 2: plug the detection chip with a small amount of blood into the chip interface module; Step 3: The analyzer identifies the test chip and performs self-test, and then starts automatic testing; Step 4: Output the test results.

[0041] Compared with the prior art, this application has the following beneficial effects: The present application discloses a portable dry biochemical analyzer and a method for using the same. The analyzer can be a detection host with a small structure, realize in-situ high-efficiency pressure filtration on a detection chip, obtain serum, and perform microfluidic channeling to enter the detection point of the detection chip to react with a dry reagent. The micro multi-band integrated light source equipped with the detection host is used to perform optical joint inspection to realize rapid and convenient biochemical detection, and at the same time greatly improve the accuracy of blood biochemical detection, effectively solving the problems existing in the prior art such as large size of biochemical detection devices, large amount of blood required for detection, long detection time, high detection cost, and limited use location and environment of biochemical detection devices. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 A three-dimensional diagram of a portable dry biochemical analyzer in an exemplary embodiment of the present application; Figure 2 This is a schematic diagram of the microfluidics principle in the detection chip in the exemplary embodiment of the present application; Figure 3This is a schematic diagram of the assembly of the machine compartment and the sliding cover in an exemplary embodiment of the present application; Figure 4 This is a schematic diagram of the structure inside the machine cage box in an exemplary embodiment of the present application; Figure 5 This is a schematic diagram of the structure of the engine compartment cover in an exemplary embodiment of the present application; Figure 6 This is a schematic diagram of the structure of the slide-in-place switch in the exemplary embodiment of the present application; Figure 7 This is a schematic diagram of the bottom structure of the sliding cover in an exemplary embodiment of the present application; Figure 8 is a side view schematic diagram of a sliding cover in an exemplary embodiment of the present application; Fig. 9 This is a schematic diagram of assembling the sliding cover and the touch display screen in an exemplary embodiment of the present application; Fig.10 This is a schematic diagram of the internal structure of the top of the sliding cover in an exemplary embodiment of the present application; Fig.11 It is a schematic structural diagram of a heat-conducting outer frame on the top of the sliding cover in an exemplary embodiment of the present application; Fig.12 is a cross-sectional view of an elastic pressure bowl in an exemplary embodiment of the present application; Fig.13 It is a front view of the elastic pressure bowl in the exemplary embodiment of the present application; Fig.14 is a three-dimensional diagram of an elastic pressure bowl in an exemplary embodiment of the present application; Fig.15 is an assembly diagram of a chip interface module in an exemplary embodiment of the present application; Fig.16 It is a schematic diagram of the structure of the chip interface module in the exemplary embodiment of the present application; Fig.17 It is a structural schematic diagram of the optical inspection slot in the exemplary embodiment of the present application; Fig.18 It is a schematic structural diagram of the positioning protrusion in the exemplary embodiment of the present application; Fig.19 This is a schematic diagram of the cooperation between the detection chip and the chip interface module in the exemplary embodiment of the present application; Fig. 20 It is a structural schematic diagram of a pressurizing module in an exemplary embodiment of the present application; Fig.21 It is a schematic structural diagram of a tilting plate in an exemplary embodiment of the present application; Fig. 22 It is a schematic diagram of the structure of the tilting and pressing bracket in the exemplary embodiment of the present application; Fig.23 is a structural block diagram of a miniature multi-frequency light source in an exemplary embodiment of the present application; Fig.24 A schematic diagram of a micro-integrated optical path structure in an exemplary embodiment of the present application; Fig.25 A schematic diagram of a second light outlet configuration in an exemplary embodiment of the present application; Fig.26 This is a schematic diagram of the assembly of the scanning light detection module in the exemplary embodiment of the present application; Fig. 27 It is a schematic diagram of the assembly of the scanning drive mechanism in the exemplary embodiment of the present application; Fig.28 This is a schematic diagram of the assembly of an integrated rack in an exemplary embodiment of the present application; Fig.29 A schematic diagram of microfluidics in an exemplary embodiment of the present application; Fig.30 A schematic diagram of optical detection in an exemplary embodiment of the present application; Fig.31 A schematic diagram of optical detection in an exemplary embodiment of the present application; Fig.32 This is a detection schematic diagram when the detection light presents a larger light spot at the sequence points in the exemplary embodiment of the present application; Fig.33 This is a detection schematic diagram when the detection light presents a relatively small light spot at the sequence points in the exemplary embodiment of the present application.

[0043] Fig.34 It is a schematic diagram of the structure of the filter element in the exemplary embodiment of the present application.

[0044] Among them, in the figure, 100, analyzer; 10, housing; 14, control and computing unit; 15, power module; 500, integrated rack; 600, cabinet; 700, slide cover; 11, chip interface module; 200, detection chip; 201, injection port; 202, filter pressure chamber; 203, sequence point; 204, microchannel; 205, detection point chamber; 206, drying reagent; 400, filter pressure element; 401, coarse filter element; 4011, coarse filter path; 402, fine filter element; 4021, fine filter path; B, detection point, 12, pressurization module; 121, elastic pressure bowl; 20, identity module; 110, identity recognition module block; 61, machine box; 62, machine cover; 621, socket slot; 6210, socket; 622, slide slot; 623, wire slot; 624, slide cover in place switch; 6241, in place U-shaped slot; 6242, infrared switch assembly; 6243, switch terminal; 701, slide block; 702, in place contact convex; 801, touch screen; 800, display and operation unit; 71, slide cover body; 72, screen slot; 721, heat conduction plate; 722, slot bottom plate; 723, heat conduction frame; LD, length direction; 1301, free end; 1302, fixed end; 1211, bowl body; 1212, tilting column head; 1213, The outside of the bottom of the bowl; 1214, the surface of the bowl mouth; 1215, the inside of the bottom of the bowl; 1216, the first bowl body section; 1217, the second bowl body section; 1218, the airtight pressure interface; 1219, the annular groove; 501, the power supply notch; 502, the fixing column; 503, the fan notch; 111, the crossbeam; 112, the plug-in slot; 113, the positioning convex; 1122, the optical inspection opening; 1123, the optical inspection notch; B0, the first detection positioning point; 11230, the sequence notch; 1124, the guide arc opening; 1121, the pressurized opening; 162, the heating plate; 161, the wiring notch; 120, the inclined arm lever type tilting and pressing unit; 1201, the tilting and pressing plate; 1202, tilting and pressing fulcrum; 1203, tilting and pressing working end; 1204, tilting and pressing driving end; 1205, tilting and pressing motor; 1206, tilting and pressing bracket; 1200, tilting and pressing travel switch; 1207, tilting and pressing limit plate; 1304, shaft groove; 1305, tilting and pressing working fork; 1306, tilting and pressing driving fork; 1307, tilting and pressing contact protrusion; tp, elastic sheet; QYZ, tilting and pressing axis; 13, scanning optical inspection module, 131, micro multi-frequency optical module; GY, micro multi-frequency light source; GS, light receiving unit; GD, power supply unit; GL, micro integrated optical path structure; G1, first frequency band optical element; G02, second frequency band optical element; G , No. Band optical components; G +1, No. +1 Band Optics; G -1, No. -1 band optical components; G , No. Frequency band optical element; R1, first frequency band detection light; R02, second frequency band detection light; R , No. Frequency band detection light; R +1, No. +1 band detection light; R -1, No. -1 band detection light; R , No. Frequency band detection light; GZ, collimation structure; GC1, first light outlet; GC2, second light outlet; S1, first dichroic mirror; S2, second dichroic mirror; S , No. Dichroic mirror; S +1, No. +1 dichroic mirror; S -1, No. -1 dichroic mirror; S , No. Dichroic mirror; T0, output lens; T1, first lens; T2, second lens; T , No. Lens; T +1, No. +1 lens; T , No. Lens; T , No. Lens; 132, optical detection slide rail; 1321, optical detection guide rod; 133, optical detection slider; 134, scanning drive mechanism; 1341, driving rack; 1342, scanning gear; 1343, scanning motor; 1331, slider groove; 1308, rib; 141, circuit board; 1000, driving air pressure; L100, transmitted light of main-band detection light, L300, transmitted light of sub-band detection light; L000, incident light of main-band detection light; L200, incident light of sub-band detection light. DETAILED DESCRIPTION

[0045] The technical solution of the present application is further described in detail below in conjunction with specific implementation methods.

[0046] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0047] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application; the terms "first", "second", and "third" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance; in addition, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be a connection between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0048] See also Figures 1 to 34 , the embodiment of the present application discloses a portable dry biochemical analyzer, including an analyzer 100, wherein the analyzer 100 cooperates with a detection chip 200 and is used for a small, convenient and rapid dry biochemical detection of a trace amount of blood; The detection chip 200 has a filter press cavity 202, a sequence point 203, and a microchannel 204 connecting the filter press cavity 202 to the sequence point 203; the filter press cavity 202 forms the injection port 201 on the upper surface of the detection chip 200, and a trace amount of blood drips into the filter press cavity 202 of the detection chip 200 through the injection port 201; The filter press cavity 202 has a filter press element 400 in the detection chip 200 for filtering blood cells to obtain serum; the sequence point 203 includes a plurality of detection points B; the detection point B forms a detection point cavity 205 in the detection chip 200; the detection point cavity 205 is connected to the filter press cavity 202 through a microchannel 204 in a one-to-one correspondence; the sequence point 203 is configured with a corresponding dry reagent 206 in the corresponding detection point cavity 205; In an exemplary embodiment, the trace amount of blood is 1-4 drops; In an exemplary embodiment, the ID information of the detection chip 200 includes the type of the detection chip 200 and the information of the dried reagent 206 built into the detection chip 200. The detection chip 200 has at least 7 types, and the corresponding detection types are liver function detection, kidney function detection, virus infection detection, glycolipid detection, pancreas detection, kidney glycolipid detection and myocardial detection; Each type of detection chip 200 corresponds to a plurality of detection items, each detection item corresponds to at least one detection point B and corresponds to at least one dried reagent 206 ; the dried reagent 206 information includes the type of dried reagent 206 and a calibration curve.

[0049] The analyzer 100 mainly includes a housing 10, a chip interface module 11, a pressurizing module 12, a scanning optical detection module 13, a control and calculation unit 14 and a power module 15; In an exemplary embodiment, the housing 10 is a small structure for accommodating the various components of the analyzer; an integrated rack 500 is provided in the housing 10; the integrated rack 500 is provided with steps corresponding to the chip interface module 11, the scanning optical detection module 13 and the pressurizing module 12 in sequence to form a stepped rack.

[0050] The other side of the integrated frame 500 relative to the chip interface module 11 is provided with a fan slot 503 for installing a heat dissipation fan; In an exemplary embodiment, the housing 10 includes a housing 600 and a sliding cover 700; The machine compartment 600 includes a machine compartment box 61 and a machine compartment cover 62; a heat dissipation window is provided on the machine compartment box 61 or the machine compartment cover 62, and a heat dissipation hole is provided on the heat dissipation window.

[0051] A socket slot 621 is provided on one side of the compartment cover 62; the socket 6210 is correspondingly arranged in the socket slot 621; The detection chip 200 is plugged into the chip interface module 11 and can be accommodated in the socket slot 621; The sliding cover 700 is slidably matched with the top of the compartment cover 62 to open or close the socket slot 621 in which the detection chip 200 is inserted.

[0052] In an exemplary embodiment, two sliding blocks 701 are symmetrically and parallelly arranged at the bottom of the sliding cover 700 along its sliding direction; A slide groove 622 is provided at one end of the top of the machine cover 62 corresponding to the slide block 701; the slide block 701 is slidably matched with the slide groove 622; A wire groove 623 is provided in the middle of the machine cover 62, and a sliding cover in place switch 624 is provided at one end of the wire groove 623 away from the slide groove 622; A position-in-place contact protrusion 702 is provided at the bottom of the sliding cover 700 corresponding to the sliding cover position-in-place switch 624 ; the sliding cover 700 is slidably matched on the top of the machine compartment cover 62 , and the position-in-place contact protrusion 702 is located in the wire groove 623 .

[0053] In an exemplary embodiment, the slide-in position switch 624 includes a U-shaped position groove 6241, an infrared switch component 6242, and a switch terminal 6243; the position contact protrusion 702 slides into the U-shaped position groove 6241 to block the infrared light emitted by the infrared switch component 6242, thereby realizing position detection; In an exemplary embodiment, the chip interface module 11 is disposed on one side of the housing 10, and is used to plug and identify the detection chip 200 dripped with a trace amount of blood, and to perform temperature control on the detection chip 200; In an exemplary embodiment, the chip interface module 11 includes a beam 111 , an identification module 110 , and a temperature control unit; The side of the housing 10 is provided with a socket 6210, and the crossbeam 111 is arranged on one side of the housing 10 close to the socket 6210, with both ends fixed in the housing 10; The crossbeam 111 is provided with a mating groove 112 corresponding to the socket 6210 at the middle position along the length direction; One end of the detection chip 200 can pass through the socket 6210 of the housing 10 and be plugged into the plug-in slot 112 of the beam 111; The detection chip 200 is provided with an identity module 20; The identity recognition module 110 corresponds to the identity module 20 of the detection chip 200 and is disposed on the housing 10 , and cooperates with the identity module 20 to identify the ID information of the detection chip 200 ; In an exemplary embodiment, the identity module 20 is a QR code, which is set on the lower side of the rear end of the detection chip 200; the identity recognition module 110 is a miniature camera, which is set at the bottom of the socket slot 621. When the detection chip 200 is plugged into the chip interface module 11, the miniature camera is aligned with the QR code of the detection chip 200.

[0054] The mating slot 112 is provided with a pressurizing opening 1121 and a light inspection opening 1122 on the upper side of the crossbeam 111; the light inspection opening 1122 extends downward and penetrates the crossbeam 111 to form a light inspection slot 1123; when the detection chip 200 is plugged into the mating slot 112, the pressurizing opening 1121 corresponds to the injection port 201 of the detection chip 200; the light inspection slot 1123 corresponds to the sequence point 203 of the detection chip 200; The temperature control unit includes a heating plate 162 and a temperature sensor, which are built into the bottom of the mating slot 112 of the crossbeam 111. When the detection chip 200 is plugged into the mating slot 112, the heating plate 162 and the temperature sensor abut against the detection chip 200. In an exemplary embodiment, a wiring notch 161 is provided at one end of the bottom of the mating slot 112 corresponding to the lower side of the heating plate 162; the temperature sensor is embedded in the heating plate 162; In an exemplary embodiment, when the detection chip 200 is plugged into the chip interface module 11 and the detection chip 200 is lower than a preset temperature, the heating plate 162 performs pulse heating on the detection chip 200 so that the detection chip 200 is quickly heated to a preset temperature range.

[0055] In an exemplary embodiment, the slot of the mating slot 112 is provided with a guide arc 1124; a positioning protrusion 113 is provided in the mating slot 112 corresponding to the front end of the detection chip 200, and a positioning slot is provided at the front end of the detection chip 200 corresponding to the positioning protrusion 113. The positioning slot is a semicircular slot, and the positioning protrusion 113 is a cylinder; the positioning protrusion 113 and the positioning slot are both provided with two and asymmetrically designed, so as to facilitate positioning and prompt the sample inlet 201 of the detection chip 200 to face upward.

[0056] In an exemplary embodiment, the pressurizing module 12 is used to precisely drive the trace amount of blood in the detection chip 200 to pass through the filter press element 400 in the filter press cavity 202, and the serum obtained by filtration flows into all the detection point cavities 205 of the sequence point 203 through the microchannels 204 in a one-to-one correspondence until the serum is filled with the dried reagent 206 correspondingly configured in the detection point cavity 205 corresponding to the sequence point 203, and then all the detection point cavities 205 corresponding to the sequence point 203 remain filled and fully reacted and wait for detection; In an exemplary embodiment, the pressurizing module 12 includes an elastic pressing bowl 121 and an inclined arm lever type inclined arm lever type pressing unit 120 for precisely pressing the elastic pressing bowl 121; the elastic pressing bowl 121 is disposed above the pressurizing opening 1121; The inclined arm lever-type lifting and pressing unit 120 drives the elastic pressure bowl 121 located above the pressurized opening 1121 to move downward, and after passing through the pressurized opening 1121 and abutting against the sampling port 201 that wraps the detection chip 200, the elastic pressure bowl 121 is precisely lifted and pressed, and the elastic pressure bowl 121 is elastically deformed, squeezing the air between the elastic pressure bowl 121 and the sampling port 201 to form a driving air pressure 1000. The driving air pressure 1000 drives the trace amount of blood to be filtered and micro-flown in the detection chip 200 to the serial point 203, and at the same time gradually squeezes and discharges the air in the microchannel 204 in the detection chip 200 and the detection point cavity 205 corresponding to the serial point 203 until the serum obtained by the filter fills all the detection point cavities 205 of the serial point 203.

[0057] In an exemplary embodiment, the detection chip 200 discharges the air in the microchannel 204 and the detection point cavity 205 corresponding to the sequence point 203 along the plane direction; In an exemplary embodiment, the oblique arm lever type tilting and pressing unit 120 is connected to the elastic pressing bowl 121, and at least one pressing point is formed on the outer side of the elastic pressing bowl 121; The inclined arm lever type tilting pressure unit 120 precisely controls the driving displacement of the pressing point, and then precisely controls the driving air pressure 1000, and then precisely controls the rate of micro-blood filtration, the flow rate of the filtered serum in the microchannel 204, and the relative pressure balance state maintained after the filtered serum fills the sequence point 203.

[0058] In an exemplary embodiment, after the serum fills the sequence point 203, the elastic deformation of the elastic pressure bowl 121 is reciprocatingly fine-tuned, and the driving air pressure 1000 is reciprocatingly fine-tuned, so that the serum is reciprocatingly filled in the detection point cavity 205, thereby promoting a rapid and sufficient re-dissolution reaction between the serum and the dried reagent 206 in the detection point cavity 205.

[0059] In an exemplary embodiment, the oblique arm lever type tilting and pressing unit 120 includes a tilting and pressing plate 1201 and a tilting and pressing fulcrum 1202; The two sides of the tilting plate 1201 relative to the tilting fulcrum 1202 respectively form a tilting working end 1203 and a tilting driving end 1204; The tilting and pressing working end 1203 of the tilting and pressing plate 1201 is connected to the elastic pressing bowl 121, and a pressing point of the elastic pressing bowl 121 is formed at the connection; When the tilting pressure driving end 1204 is displaced relative to the tilting pressure fulcrum 1202 , the tilting pressure working end 1203 on the other side of the tilting pressure fulcrum 1202 is driven to be displaced.

[0060] In an exemplary embodiment, the elastic pressure bowl 121 includes a bowl body 1211 and a pressure column head 1212. The mouth of the elastic pressing bowl 121 faces downward, and the vertical direction is the length direction LD; the elastic pressing bowl 121 is made of integrated silicone; One end of the bowl body 1211 along the length direction LD is a bowl bottom outer surface 1213, and the other end is a bowl mouth surface 1214; Between the outer surface 1213 of the bowl bottom and the bowl mouth surface 1214, there are an inner surface 1215 of the bowl bottom, a first bowl body cross section 1216 and a second bowl body cross section 1217; The inner diameter and outer diameter of the bowl body 1211 between the inner surface 1215 of the bowl bottom and the first bowl body section 1216 gradually increase; The inner diameter and the outer diameter of the bowl body 1211 gradually decrease between the first bowl body cross section 1216 and the second bowl body cross section 1217; The inner diameter of the bowl body 1211 between the second bowl body cross section 1217 and the bowl mouth surface 1214 gradually increases, while the outer diameter first gradually increases and then gradually decreases, forming an airtight pressure interface 1218; The warping column head 1212 is columnar; one end of the warping column head 1212 along the length direction LD is a fixed end 1302, and the other end is a free end 1301; The outer diameter of the warping column head 1212 between the free end 1301 and the fixed end 1302 gradually increases, and the fixed end 1302 is connected to the bottom surface of the bowl; An annular groove 1219 for clamping is provided in the middle of the tilting and pressing column head 1212, and both ends of the annular groove 1219 transition to the tilting and pressing column head 1212 in an arc shape; The tilting and pressing working end 1203 is provided with a fork and is clamped on the annular groove through the fork.

[0061] In an exemplary embodiment, the inclined arm lever type tilting and pressing unit 120 also includes a tilting and pressing motor 1205 installed in the housing 10. The tilting and pressing motor 1205 is a linear motor. The output shaft of the tilting and pressing motor 1205 is connected to the tilting and pressing driving end 1204, and can drive the tilting and pressing driving end 1204 to produce displacement relative to the tilting and pressing fulcrum 1202.

[0062] In an exemplary embodiment, the tilting fulcrum 1202 is a tilting axis QYZ, which is installed in the housing 10 through a tilting bracket 1206. The tilting bracket 1206 is provided with a tilting travel switch 1200 corresponding to the tilting plate 1201, and the tilting plate 1201 is provided with a tilting contact protrusion 1307 corresponding to the tilting travel switch 1200.

[0063] In an exemplary embodiment, a tilting pressure limiting plate 1207 is provided on the tilting pressure bracket 1206 corresponding to the tilting pressure axis QYZ and close to the tilting pressure driving end 1204 .

[0064] In an exemplary embodiment, an elastic sheet tp is connected to the end of the tilting axis QYZ for elastic tilting effect; the elastic sheet tp can be a torsion spring.

[0065] In an exemplary embodiment, the tilting plate 1201 is in a diamond shape; the two ends of the tilting plate 1201 along the length direction respectively form a tilting working end 1203 and a tilting driving end 1204; the connecting line of the tilting working end 1203 and the tilting driving end 1204 is obliquely intersected with the crossbeam 111 to form an oblique arm lever; The tilting and pressing working end 1203 forms a tilting and pressing working fork 1305 adapted to the annular groove of the tilting and pressing column head 1212; The tilting pressure driving end 1204 forms a tilting pressure driving fork 1306 adapted to the output shaft of the tilting pressure motor 1205; The middle part of the tilting plate 1201 is provided with an axis groove 1304 for installing the tilting axis QYZ; A tilting pressure contact protrusion 1307 cooperating with the tilting pressure travel switch 1200 is provided on the side of the tilting pressure plate 1201 .

[0066] In an exemplary embodiment, the upper and lower sides of the tilting plate 1201 are evenly provided with ribs 1308, and the ribs 1308 are arranged along the length direction of the tilting plate 1201; the tilting working fork 1305 is a circular fork; and the tilting driving fork 1306 is a U-shaped fork.

[0067] In an exemplary embodiment, in order to ensure the filter pressing effect and make the filter pressing proceed smoothly, the filter pressing filter element 400 of the detection chip 200 includes a coarse filter element 401 and a fine filter element 402 arranged in sequence; the filter hole diameter of the coarse filter element 401 is larger than that of the fine filter element 402; the coarse filter path 4011 of the coarse filter element 401 is much larger than the fine filter path 4021 of the fine filter element 402. The design of the coarse filter element 401 improves the filter pressing efficiency, and the design of the fine filter element 402 ensures the filter pressing effect, effectively filters blood cells, and avoids the interference of blood cells on blood detection; In an exemplary embodiment, the scanning optical inspection module 13 is used to precisely drive the detection light of the micro multi-frequency optical module 131 to perform corresponding optical scanning inspection on the sequence points 203 of the detection chip 200 to be detected, so as to obtain the multi-link optical detection information of the detection chip 200; In an exemplary embodiment, the optical inspection slot 1123 includes a first inspection positioning point B0 and a sequence slot 11230; When the detection chip 200 is abutted and matched in the mating slot 112, the sequence point 203 corresponds to the sequence slot 11230; in an exemplary embodiment, the first detection positioning point B0 is located at the outer side of the detection chip 200, and the detection light of the micro multi-frequency optical module 131 can pass through the first detection positioning point B0 without obstruction; In some other embodiments, the first detection positioning point B0 is located on the detection chip 200 , and the detection chip 200 is provided with a hole corresponding to the first detection positioning point B0 .

[0068] In an exemplary embodiment, the scanning optical detection module 13 includes a micro multi-frequency optical module 131, an optical detection slide rail 132, an optical detection slider 133 and a scanning drive mechanism 134. The micro multi-frequency optical module 131 includes a micro multi-frequency light source GY, which is used to select a detection light output of a frequency band from multiple frequency bands according to the frequency band; and a light receiving unit GS, which is used to receive the detection light and obtain optical detection information; The optical detection slider 133 is slidably matched on the optical detection slide rail 132, and the optical detection slider 133 has a slider groove 1331; the optical detection notch 1123 extends into the slider groove 1331; the micro multi-frequency light source GY and the light receiving unit GS in the micro multi-frequency optical module 131 are respectively configured on the optical detection slider 133 corresponding to the slider groove 1331, so that the optical detection notch 1123 is located between the micro multi-frequency light source GY and the light receiving unit GS; in an exemplary embodiment, the micro multi-frequency light source GY is located on the lower side, and the light receiving unit GS is located on the upper side; in some other embodiments, the micro multi-frequency light source GY is located on the upper side, and the light receiving unit GS is located on the lower side; The scanning drive mechanism 134 is connected to the optical detection slider 133 to drive the optical detection slider 133 to move precisely along the optical detection rail 132, driving the micro multi-frequency optical module 131 to optically detect the sequence points 203 of the detection chip 200 and the first detection positioning point B0 one by one.

[0069] In an exemplary embodiment, the sequence point 203 includes M detection points B from B1 to BM; in an exemplary embodiment, M is 9; that is, the sequence point 203 includes 9 detection points BB1 to BB9; In an exemplary embodiment, the sequence point 203 and the first detection positioning point B0 are arranged in a straight line; at this time, the optical detection slide rail 132 is a linear slide rail; and the scanning drive mechanism 134 is configured accordingly; In an exemplary embodiment, the intervals of the detection points B in the sequence point position 203 are evenly arranged, the first detection positioning point B0 is located on the extension line of the line connecting the detection points B in the sequence point position 203, and the distance between the first detection positioning point B0 and the nearest detection point B is an integer multiple of the distance between adjacent detection points B; In some other embodiments, the intervals of the detection points B are arranged non-uniformly; in some other embodiments, the sequence points 203 and the first detection positioning point B0 are arranged in a curve; in this case, the optical detection slide rail 132 is a curved slide rail; and the scanning drive mechanism 134 is configured accordingly; In an exemplary embodiment, the optical inspection slide rail 132 includes at least two optical inspection guide rods 1321; the optical inspection slider 133 has guide rod holes; the optical inspection slider 133 is slidably fitted on the optical inspection guide rods 1321; In an exemplary embodiment, the scanning drive mechanism 134 includes a driving rack 1341, a scanning gear 1342 and a scanning motor 1343 installed in the housing 10; the driving rack 1341 is connected to the side of the optical detection slider 133 away from the slider groove 1331, and the scanning gear 1342 is connected to the output shaft of the scanning motor 1343 and meshes with the driving rack 1341 for transmission.

[0070] In an exemplary embodiment, the micro multi-frequency optical module 131 includes a micro multi-frequency light source GY, which is used to selectively output at least one frequency band of detection light in a plurality of frequency bands according to the frequency band, and the plurality of frequency bands of detection light include the first frequency band detection light R1 to the second frequency band detection light R2. Frequency band detection light R common The detection light of the frequency band is is an integer greater than 1; and a light receiving unit GS, for receiving the detection light and obtaining optical detection information; The micro multi-frequency light source GY includes a first frequency band optical element G1 to a second frequency band optical element G2. Band Optical Components G , used to generate the first frequency band detection light to the Frequency band detection light; The micro-integrated optical path structure GL includes a plurality of dichroic mirrors for reflecting or transmitting the first frequency band detection light to the second frequency band detection light. frequency band detection light, shortening and conducting the first frequency band detection light to the The first light outlet GC1 is used for transmitting the first frequency band detection light to the first light outlet GC1; The frequency band detection light is emitted to the outside of the micro multi-frequency light source GY; and the collimation structure GZ is used for the first frequency band detection light R1 to the second frequency band detection light R2. Frequency band detection light R Collimation in the optical path.

[0071] In an exemplary embodiment, the micro multi-frequency light source GY further includes a second light outlet GC2 for transmitting the first frequency band detection light R1 to the second frequency band detection light R2. Frequency band detection light R The micro-integrated optical circuit structure GL shortens the conduction of the first frequency band detection light R1 to the first frequency band detection light R2. Frequency band detection light R The optical path in which the detection light of at least one frequency band is transmitted to the second light output port GC2.

[0072] In an exemplary embodiment, the micro-integrated optical path structure GL includes a first dichroic mirror S1 to a second dichroic mirror S2. Dichroic Mirror S , The first dichroic mirror S1 is used for reflecting the first frequency band detection light R1 to the second dichroic mirror S2; No. Dichroic Mirror S , used for detecting light R1 in the first frequency band to 1 band detection light R 1 Transmit to Dichroic Mirror S and Frequency band detection light R Reflect to Dichroic Mirror S ;in, 1 to integer; No. Dichroic Mirror S ; Used for the first frequency band detection light R1 to the first The frequency band detection light is transmitted to the Dichroic Mirror S and Frequency band detection light Reflect to Dichroic Mirror S ; No. Dichroic Mirror S , corresponding to the first light outlet GC1, used for detecting the first frequency band light R1 to the Frequency band detection light Reflected to the first light outlet GC1, and the Frequency band detection light R In an exemplary embodiment, the first dichroic mirror S1 to the first Dichroic Mirror S common The dichroic mirrors are stacked end to end in an alternating pattern, extending in a wave shape. The first frequency band optical elements G1 to G2 Band Optical Components G common The optical elements are arranged alternately from the first dichroic mirror S1 to the Dichroic Mirror S side.

[0073] In an exemplary embodiment, the collimating structure includes an output lens T0 , and the output lens T0 is disposed between the micro-integrated optical path structure GL and the first light output port GC1 .

[0074] In an exemplary embodiment, the collimating structure GZ includes a first lens T1 to a second lens T2. Lens T , respectively corresponding to the optical elements G1 to G2 in the first frequency band Band Optical Components G for correspondingly generating the first frequency band detection light R1 to the first Frequency band detection light R of collimation.

[0075] In an exemplary embodiment, the micro multi-frequency light source GY further includes a power supply unit GD for supplying power to the first frequency band optical elements G1 to the second frequency band optical elements G2. Band Optical Components G Selectively supply single precision power and selectively output the first frequency band detection light R1 to the Frequency band detection light R ; When the first frequency band optical element G1 to the Band Optical Components G When the power supply parameters of any optical element are consistent twice, the parameters of the detection light outputted by it under the same optical path remain consistent; Among them, the power supply parameters include voltage and current; Parameters of the detected light include light intensity.

[0076] In an exemplary embodiment, the scanning optical detection module 13 matches at least two frequency bands of detection light to each detection point B in the sequence point position 203 and sequentially transmits optical detection; The two frequency bands of detection light include a main frequency band detection light, and the main frequency band detection light can be characteristically absorbed by a product of a reaction between the built-in dried reagent 206 and the serum corresponding to the detection point B, and is used for characteristic absorption detection of the detection point B; and a sub-band detection light, wherein the sub-band detection light cannot be characteristically absorbed by a product of a reaction between the built-in dried reagent 206 and the serum at the corresponding detection point B, and is used for characteristic absorption detection correction at the detection point B; The main frequency band detection light and the sub-frequency band detection light are the first frequency band detection light to the second frequency band detection light. The frequency band detects two types of light.

[0077] In an exemplary embodiment, the light receiving unit GS is a light intensity detection unit, which is used to detect the intensity of the first frequency band detection light to the first frequency band detection light. N The frequency band detects the light intensity; The light intensity detection unit is used to detect the light intensity of the incident light L000 of the main frequency band detection light and the light intensity of the transmitted light L100 of the main frequency band detection light in the transmission light detection process respectively; As well as the light intensity of the incident light L200 of the sub-band detection light and the light intensity of the transmitted light L300 of the sub-band detection light.

[0078] In an exemplary embodiment, when the spot diameter of the matching main-band detection light and / or sub-band detection light on the sequence point 203 is close to the diameter of the detection point B, exemplarily, when the absolute value of the difference between the two is less than or equal to the preset value, the scanning optical detection module 13 drives the detection light to perform transmission optical detection at the center of the detection point B; When the spot diameter of the matching main-band detection light and / or sub-band detection light at the serial point 203 is smaller than the diameter of the detection point B and the difference is large, exemplarily, when the absolute value of the difference between the two is greater than the preset value, the preset value can be 0.2mm; the scanning optical detection module 13 drives the detection light to move within the plane range of the detection point B for scanning optical detection.

[0079] Summarize the optical detection information of each detection point B in the sequence point 203 and the first detection positioning point B0 to obtain the multi-link optical detection information of the detection chip 200; In an exemplary embodiment, the control and calculation unit 14 is used to coordinate control and perform analysis and calculation based on the obtained multi-link optical detection information of the detection chip 200, obtain and output the detection result corresponding to the detection chip 200; in an exemplary embodiment, the control and calculation unit 14 is integrated on two overlapping and plug-connected circuit boards 141; the analysis and calculation method can adopt a quantitative analysis method of characteristic absorption, and the present application uses sub-band detection light to correct the characteristic absorption of the detection point B to improve the detection accuracy; in an exemplary embodiment, the Lambert-Beer law can be used for quantitative analysis, which is not specifically described in this application; The other side of the integrated frame 500 is provided with a plurality of fixing posts 502 connected to the circuit board 141; In an exemplary embodiment, a power slot 501 for accommodating a power module 15 is provided on one side of the integrated frame 500 ; the power module 15 is used to supply power to the biochemical analyzer 100 .

[0080] In an exemplary embodiment, the analyzer 100 further includes a display and operation unit 800 , wherein the display and operation unit 800 includes a touch screen 801 , and the touch screen 801 is disposed on the top of the slide cover 700 ; In an exemplary embodiment, the sliding cover 700 includes a sliding cover body 71 and a screen groove 72 , a heat conducting plate 721 and a groove bottom plate 722 supporting the heat conducting plate 721 are provided at the bottom of the screen groove 72 , and a heat conducting outer frame 723 is provided on the side of the groove bottom plate 722 corresponding to the heat conducting plate 721 .

[0081] On the other hand, the embodiment of the present application also discloses a method for using the above-mentioned portable dry biochemical analyzer, including: step 1, sliding the slide cover to open the chip interface module; Step 2: plug the detection chip with a small amount of blood into the chip interface module; Step 3: The analyzer identifies the test chip and performs self-test, and then starts automatic testing; Step 4: Output the test results.

[0082] In an exemplary embodiment, a database may be constructed and accessed through an APP including WeChat to query the test results.

[0083] Working principle of the embodiment of the present application: The embodiment of the present application discloses a portable dry biochemical analyzer based on warp pressure drive and a method of use. The analyzer can be a detection host with a small structure, which realizes in-situ high-efficiency pressure filtration on the detection chip to obtain serum, and performs microfluidic channeling to enter the detection point of the detection chip to react with the dry reagent. The micro multi-band integrated light source equipped with the detection host is used to perform optical joint inspection to achieve fast and convenient biochemical detection, while greatly improving the accuracy of blood biochemical detection, effectively solving the problems existing in the prior art such as large size of biochemical detection devices, large amount of blood required for detection, long detection time, high detection cost, and limited use location and environment of biochemical detection devices.

Claims

1. A portable dry biochemical analyzer, characterized in that: The invention comprises an analyzer, which cooperates with a detection chip for convenient dry biochemical detection of trace blood; the detection chip is equipped with a filter press cavity, sequence points, a microchannel, a detection point cavity and a drying reagent; The analyzer includes a housing for accommodating the components of the analyzer; The chip interface module is arranged on one side of the housing, and is used to plug and identify the detection chip dripped with a trace amount of blood, and to control the temperature of the detection chip; The pressurizing module is used to precisely drive the trace amount of blood in the detection chip to be filtered through the filter press cavity, and the serum obtained by filtration flows into all the detection point cavities of the sequence points one by one through the microchannels until the serum is filled with the dried reagents correspondingly configured in the detection point cavities corresponding to the sequence points, and then all the detection point cavities corresponding to the sequence points are kept filled and fully reacted and wait for detection; A scanning optical inspection module is used to precisely drive the detection light of the micro multi-frequency optical module to perform corresponding optical scanning and penetration inspection on the sequence points of the detection chip waiting for detection, so as to obtain the multi-link optical detection information of the detection chip; A control and calculation unit, used for coordinating control and performing analysis and calculation based on the obtained multi-link optical detection information of the detection chip, to obtain and output the detection result corresponding to the detection chip; and a power module for supplying power.

2. The portable dry biochemical analyzer according to claim 1, characterized in that: The filter press cavity forms an injection port on the upper surface of the detection chip, and a trace amount of blood drips into the filter press cavity of the detection chip through the injection port; The filter press cavity is provided with a filter press element for filtering blood cells to obtain serum; the sequence point position includes a plurality of detection points; the detection point forms a detection point cavity in the detection chip; The detection point cavity is connected to the filter press cavity through a one-to-one correspondence branch channel through a microchannel; and the sequence point is configured with a corresponding dry reagent in the corresponding detection point cavity.

3. The portable dry biochemical analyzer according to claim 2, characterized in that: The chip interface module includes a crossbeam, an identity recognition module and a temperature control unit; The side of the housing is provided with a socket, the crossbeam is arranged on a side of the housing close to the socket, and both ends are fixed in the housing; The crossbeam is provided with a mating groove corresponding to the socket at the middle position along the length direction; One end of the detection chip can pass through the socket of the housing and be plugged into the plug-in slot of the beam; The detection chip is provided with an identity module; The identity recognition module corresponds to the identity module of the detection chip and is arranged on the housing, and cooperates with the identity module to identify the ID information of the detection chip; The mating slot is provided with a pressurized opening and an optical inspection opening on the upper side of the crossbeam; the optical inspection opening extends downward and penetrates the crossbeam to form an optical inspection slot; when the detection chip is plugged into the mating slot, the pressurized opening corresponds to the sample inlet of the detection chip; the optical inspection slot corresponds to the sequence point of the detection chip; The temperature control unit includes a heating plate and a temperature sensor, which are built into the bottom of the plug-in slot of the crossbeam. When the detection chip is plugged into the plug-in slot, the heating plate and the temperature sensor abut against the detection chip.

4. The portable dry biochemical analyzer according to claim 3, characterized in that: The ID information of the detection chip includes the type of the detection chip and the information of the desiccated reagent built into the detection chip. The detection chip has at least 7 types, and the corresponding detection types are liver function detection, kidney function detection, virus infection detection, glycolipid detection, pancreas detection, kidney glycolipid detection and myocardial detection; Each type of detection chip corresponds to a plurality of detection items, each detection item corresponds to at least one detection point, and corresponds to at least one dried reagent; the dried reagent information includes the type of dried reagent and a calibration curve.

5. The portable dry biochemical analyzer according to claim 3, characterized in that: When the detection chip is plugged into the chip interface module and the detection chip is lower than the preset temperature, the heating plate performs pulse heating on the detection chip, so that the detection chip is quickly heated to the pre-test temperature range.

6. The portable dry biochemical analyzer according to claim 3, characterized in that: The pressurizing module comprises an elastic pressing bowl and an inclined arm lever type inclined arm lever type pressurizing unit for precisely pressing the elastic pressing bowl; the elastic pressing bowl is arranged above the pressurizing opening; The inclined arm lever-type lifting and pressing unit drives the elastic pressure bowl located above the pressurized opening to move downward. After passing through the pressurized opening and abutting the sampling port wrapped around the detection chip, the elastic pressure bowl is precisely lifted and elastically deformed, squeezing the air between the elastic pressure bowl and the sampling port to form a driving air pressure. The driving air pressure pushes the trace amount of blood to be filtered and micro-flown to the sequence points in the detection chip, and at the same time gradually squeezes and discharges the air in the microchannel in the detection chip and the detection point cavity corresponding to the sequence points until the serum obtained by the filtration fills all the detection point cavities of the sequence points.

7. The portable dry biochemical analyzer according to claim 6, characterized in that: The oblique arm lever type tilting and pressing unit is connected to the elastic pressing bowl, and at least one pressing point is formed on the outer side of the elastic pressing bowl; The inclined arm lever-type tilting pressure unit precisely controls the driving displacement of the pressing point, and then precisely controls the driving air pressure, and then precisely controls the rate of micro-blood filtration, the flow rate of the filtered serum in the microchannel, and maintains a relative pressure balance after the filtered serum fills the sequence points.

8. The portable dry biochemical analyzer according to claim 7, characterized in that: When the serum fills the sequence points, the elastic deformation of the elastic pressure bowl is reciprocated and fine-tuned, and the driving air pressure is reciprocated and fine-tuned, so that the serum is reciprocated and filled in the detection point cavity, promoting a rapid and full re-dissolution reaction between the serum and the dried reagent in the detection point cavity.

9. The portable dry biochemical analyzer according to claim 7, characterized in that: The oblique arm lever type tilting and pressing unit comprises a tilting and pressing plate and a tilting and pressing fulcrum; The two sides of the tilting plate relative to the tilting fulcrum respectively form a tilting working end and a tilting driving end; The tilting and pressing working end of the tilting and pressing plate is connected to the elastic pressing bowl, and a pressing point of the elastic pressing bowl is formed at the connection; When the tilting pressure driving end is displaced relative to the tilting pressure fulcrum, the tilting pressure working end on the other side of the tilting pressure fulcrum is driven to be displaced.

10. The portable dry biochemical analyzer according to claim 9, characterized in that: The elastic pressure bowl comprises a bowl body and a warping pressure column head, one end of the bowl body along the length direction is the outer surface of the bowl bottom, and the other end is the bowl mouth surface; The area between the outer surface of the bowl bottom and the bowl mouth is provided with an inner surface of the bowl bottom, a first bowl body section and a second bowl body section; The inner diameter and outer diameter of the bowl body between the inner surface of the bowl bottom and the first bowl body cross section gradually increase; The inner diameter and outer diameter of the bowl body gradually decrease between the first bowl body section and the second bowl body section; The inner diameter of the bowl body between the second bowl body cross section and the bowl mouth surface gradually increases, while the outer diameter first gradually increases and then gradually decreases, forming an airtight pressure interface; The warped column head is columnar; one end of the warped column head along the length direction is a fixed end, and the other end is a free end; The outer diameter of the warping column head between the free end and the fixed end gradually increases, and the fixed end is connected to the bottom surface of the bowl; An annular groove for clamping is provided in the middle of the warping column head, and both ends of the annular groove are in arc transition with the warping column head; The tilting and pressing working end is provided with a fork opening and is clamped on the annular groove through the fork opening.

11. The portable dry biochemical analyzer according to claim 9, characterized in that: The oblique arm lever type tilting and pressing unit also includes a tilting and pressing motor installed in the casing. The tilting and pressing motor is a linear motor. The output shaft of the tilting and pressing motor is connected to the tilting and pressing driving end, and can drive the tilting and pressing driving end to produce displacement relative to the tilting and pressing fulcrum.

12. The portable dry biochemical analyzer according to claim 9, characterized in that: The tilting pressure fulcrum is a tilting pressure shaft, which is installed in the casing through a tilting pressure bracket. A tilting pressure travel switch is provided on the tilting pressure bracket corresponding to the tilting pressure plate, and a tilting pressure contact protrusion is provided on the tilting pressure plate corresponding to the tilting pressure travel switch.

13. The portable dry biochemical analyzer according to claim 12, characterized in that: The tilting plate is in a diamond shape; the two ends of the tilting plate along the length direction respectively form a tilting working end and a tilting driving end; the connecting line of the tilting working end and the tilting driving end obliquely intersects with the crossbeam to form an oblique arm lever; The tilting and pressing working end forms a tilting and pressing working fork adapted to the annular groove of the tilting and pressing column head; The tilting pressure driving end forms a tilting pressure driving fork adapted to the output shaft of the tilting pressure motor; The middle part of the tilting plate is provided with an axis groove for installing the tilting axis; A tilting and pressing contact convexity cooperating with the tilting and pressing travel switch is arranged on the side of the tilting and pressing plate.

14. The portable dry biochemical analyzer according to claim 3, characterized in that: The optical inspection slot includes a first inspection positioning point and a sequence slot; When the detection chip is abutted and matched in the mating slot, the sequence points correspond to the sequence slots; The first detection positioning point is located at the outer side of the detection chip or on the detection chip; the detection light of the micro multi-frequency optical module can pass through the first detection positioning point without obstruction.

15. The portable dry biochemical analyzer according to claim 14, characterized in that: The scanning optical detection module includes a micro multi-frequency optical module, an optical detection slide rail, an optical detection slider, and a scanning drive mechanism. The micro multi-frequency optical module includes a micro multi-frequency light source, which is used to select a detection light output of a frequency band from multiple frequency bands according to the frequency band; and a light receiving unit, used for receiving the detection light and obtaining optical detection information; The optical detection slider is slidably matched on the optical detection slide rail, and the optical detection slider has a slider slot; the optical detection slot extends into the slider slot; the micro multi-frequency light source and the light receiving unit in the micro multi-frequency optical module are respectively configured on the optical detection slider corresponding to the slider slot, so that the optical detection slot is located between the micro multi-frequency light source and the light receiving unit; The scanning drive mechanism is connected to the optical inspection slider, driving the optical inspection slider to move precisely along the optical inspection slide rail, driving the micro multi-frequency optical module to optically inspect the serial points of the detection chip and the first detection positioning point one by one.

16. The portable dry biochemical analyzer according to claim 15, characterized in that: The micro multi-frequency optical module includes a micro multi-frequency light source, which is used to selectively output at least one frequency band of detection light in multiple frequency bands according to the frequency band, and the multiple frequency bands of detection light include the first frequency band detection light to the second frequency band detection light. Frequency band detection optical The detection light of the frequency band is is an integer greater than 1; and a light receiving unit, for receiving the detection light and obtaining optical detection information; Wherein, the micro multi-frequency light source includes a first frequency band optical element to a frequency band optical element, used to generate the first frequency band detection light to the Frequency band detection light; The micro-integrated optical path structure includes a plurality of dichroic mirrors for reflecting or transmitting a first frequency band detection light to a second frequency band detection light. frequency band detection light, shortening and conducting the first frequency band detection light to the An optical path for transmitting the frequency band detection light to the first light outlet; The first light outlet is used for the detection light of the first frequency band to The frequency band detection light is emitted out of the micro multi-frequency light source; and a collimation structure for detecting light in the first frequency band to the The frequency band detects the collimation of the light in the optical path.

17. The portable dry biochemical analyzer according to claim 16, characterized in that: The micro multi-frequency light source also includes a second light outlet for transmitting the first frequency band detection light to the second The micro-integrated optical path structure shortens the conduction of the first frequency band detection light to the first frequency band detection light. An optical path for transmitting detection light of at least one frequency band among the frequency band detection lights to the second light outlet.

18. The portable dry biochemical analyzer according to claim 16, characterized in that: The micro-integrated optical path structure includes a first dichroic mirror to a Dichroic mirror, Wherein, the first dichroic mirror is used for reflecting the detection light of the first frequency band to the second dichroic mirror; No. Dichroic mirror, used to detect light in the first frequency band to the second 1 band detection light is transmitted to the Dichroic mirror and The frequency band detection light is reflected to the A dichroic mirror, where 1 to integer; No. Dichroic mirror, used to detect light in the first frequency band to the second The frequency band detection light is transmitted to the Dichroic mirror and The frequency band detection light is reflected to the Dichroic mirror; No. The dichroic mirror corresponds to the first light outlet and is used to detect the light from the first frequency band to the The frequency band detection light is reflected to the first light outlet, and the The frequency band detection light is transmitted to the first light outlet.

19. The portable dry biochemical analyzer according to claim 18, characterized in that: The first dichroic mirror to the Dichroic Mirrors The dichroic mirrors are stacked end to end in an alternating pattern, extending in a wave shape. The first frequency band optical element to the Frequency band optical components The optical elements are arranged alternately from the first dichroic mirror to the The side of the dichroic mirror.

20. The portable dry biochemical analyzer according to claim 19, characterized in that: The collimating structure comprises an output lens, and the output lens is arranged between the micro-integrated optical path structure and the first light outlet.

21. The portable dry biochemical analyzer according to claim 19, characterized in that: The collimating structure includes a first lens to a lenses, respectively arranged in the first frequency band optical element to the The side of the frequency band optical element is used for collimating the first frequency band detection light to the second frequency band detection light generated accordingly.

22. The portable dry biochemical analyzer according to claim 16, characterized in that: The micro multi-frequency light source also includes a power supply unit for selectively and accurately supplying power to the first frequency band optical element to the second frequency band optical element, and selectively outputting the first frequency band detection light to the third frequency band optical element. Frequency band detection light; When the first frequency band optical element to the When the power supply parameters of any optical element of the frequency band optical element are consistent twice, the parameters of the detection light outputted by it under the same optical path are consistent; Among them, the power supply parameters include voltage and current; Parameters of the detected light include light intensity.

23. The portable dry biochemical analyzer according to claim 16, characterized in that: The optical detection slide rail includes at least two optical detection guide rods; the optical detection slider is provided with a guide rod hole; the optical detection slider is slidably fitted on the optical detection guide rod; the scanning drive mechanism includes a driving rack, a scanning gear and a scanning motor installed in the housing; the driving rack is connected to the side of the optical detection slider away from the slider groove, and the scanning gear is connected to the output shaft of the scanning motor and meshes with the driving rack for transmission.

24. The portable dry biochemical analyzer according to claim 16, characterized in that: The scanning optical detection module matches at least two frequency bands of detection light to each detection point in the sequence of points for sequential transmission optical detection; The two frequency bands of detection light include main frequency band detection light, and the main frequency band detection light can be characteristically absorbed by the product of the reaction between the built-in desiccated reagent and the serum at the corresponding detection point, and is used for characteristic absorption detection of the detection point; and a sub-band detection light, wherein the sub-band detection light cannot be characteristically absorbed by a product of a reaction between a built-in desiccated reagent and serum at a corresponding detection point, and is used for correction of characteristic absorption detection at the detection point; The main frequency band detection light and the sub-frequency band detection light are the first frequency band detection light to the second frequency band detection light. The frequency band detects two types of light.

25. The portable dry biochemical analyzer according to claim 24, characterized in that: The light receiving unit is a light intensity detection unit, which is used to detect the light intensity of the first frequency band detection light to the Nth frequency band detection light; Using a light intensity detection unit to respectively detect the incident light intensity and the transmitted light intensity of the main frequency band detection light in the transmission light detection process; As well as the incident light intensity and transmitted light intensity of the sub-band detection light.

26. The portable dry biochemical analyzer according to claim 24, characterized in that: When the spot diameter of the corresponding main frequency band detection light and / or sub-frequency band detection light at the sequence point is close to the diameter of the detection point, the scanning optical detection module drives the detection light to perform transmission optical detection at the center of the detection point; When the spot diameter of the corresponding main-band detection light and / or sub-band detection light at the sequence point is smaller than the diameter of the detection point and the absolute value of the difference between the two is greater than a preset value, the scanning optical detection module drives the detection light to move within the plane range of the detection point for scanning optical detection.

27. The portable dry biochemical analyzer according to any one of claims 3 to 26, characterized in that: An integrated frame is arranged in the casing; the integrated frame is provided with steps corresponding to the chip interface module, the scanning light detection module and the pressurizing module in sequence to form a stepped frame.

28. The portable dry biochemical analyzer according to claim 27, characterized in that: The identity module is a QR code; the identity recognition module is a miniature camera.

29. The portable dry biochemical analyzer according to claim 27, characterized in that: The housing includes a housing and a sliding cover; The machine compartment includes a machine compartment box and a machine compartment cover; A socket slot is provided on one side of the compartment cover; the socket is correspondingly arranged in the socket slot; The detection chip is plugged into the chip interface module and can be accommodated in the socket slot; The sliding cover is slidably matched with the top of the machine compartment cover, and can open or close the socket slot where the detection chip is inserted.

30. The portable dry biochemical analyzer according to claim 29, characterized in that: The bottom of the sliding cover is provided with two sliding blocks symmetrically and parallelly along its sliding direction; A slide groove is provided at one end of the top of the engine cover corresponding to the slide block; the slide block and the slide groove are slidably matched; A wire groove is provided in the middle of the engine cover, and a sliding cover in place switch is provided at the end of the wire groove away from the slide groove; The bottom of the sliding cover is provided with an in-place contact protrusion corresponding to the sliding cover in-place switch; the sliding cover is slidably matched with the top of the machine compartment cover, and the in-place contact protrusion is located in the wire groove.

31. The portable dry biochemical analyzer according to claim 29, characterized in that: The analyzer also includes a display and operation unit, which includes a touch screen, and the touch screen is arranged on the top of the sliding cover. The sliding cover includes a sliding cover body and a screen groove. A heat conducting plate and a groove bottom plate supporting the heat conducting plate are arranged at the bottom of the screen groove, and a heat conducting outer frame is arranged on the side of the groove bottom plate corresponding to the heat conducting plate.

32. The method for using the portable dry biochemical analyzer according to claim 29, characterized in that: include: Step 1: Slide the cover to open the chip interface module; Step 2: plug the detection chip with a small amount of blood into the chip interface module; Step 3: The analyzer identifies the test chip and performs self-test, and then starts automatic testing; Step 4: Output the test results.

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