Sphingosine single cell fermentation product extract composition and preparation method thereof

Abstract

The invention discloses a sphingosine single cell fermentation product extract composition and a preparation method thereof, and relates to the technical field of personal care products. The sphingosine single-cell bacterium fermentation product extract composition is prepared from the following components in parts by weight: 0.5 to 5 parts of sphingosine, 0.3 to 3 parts of sphingosine single-cell bacterium fermentation product extract, 1 to 5 parts of methyl glucose polyether-20, 0.01 to 0.5 part of lactic acid, 3 to 7 parts of glycerol, 10 to 20 parts of emulsifier, 0.5 to 1 part of antibacterial agent, 0.1 to 2 parts of EDTA (Ethylene Diamine Tetraacetic Acid) disodium and the balance of deionized water. The sphingosine single cell fermentation product extract composition disclosed by the invention is high in stability, wide in pH platform, high in oil loading capacity, long in moisturizing effect and fresh and cool in skin feeling.

Description

Technical Field

[0001] The present invention relates to the field of personal care products, and in particular to a sphingomonas fermentation product extract composition and a preparation method thereof. Background Art

[0002] In the development of modern cosmetics and personal care products, consumers have higher requirements for the naturalness, mildness and efficacy of products. Although traditional synthetic chemical ingredients can provide certain efficacy, their potential irritation and environmental impact are increasingly concerned. Therefore, the development of new compositions based on natural plant extracts and microbial fermentation products has become a trend in the industry.

[0003] As a natural polysaccharide with multiple biological activities, sphingosine gum can be used as a carrier in skin care, sun protection, and cosmetics to carry functional ingredients and achieve different skin care purposes. However, there is currently a lack of a sphingosine monocellular bacteria fermentation product extract composition with strong compatibility, high stability, wide pH platform, high oil loading, long-lasting moisturizing, and refreshing skin feel. Summary of the invention

[0004] The present invention is made in view of the above-mentioned problems and provides a sphingomonas fermentation product extract composition and a preparation method thereof.

[0005] The first aspect of the present invention provides a sphingosine monocyte fermentation product extract composition, which comprises, by weight, 0.5 to 5 parts of phytosphingosine, 0.3 to 3 parts of sphingosine monocyte fermentation product extract, 1 to 5 parts of methyl glucose polyether-20, 0.01 to 0.5 parts of lactic acid, 3 to 7 parts of glycerol, 10 to 20 parts of emulsifier, 0.5 to 1 part of antibacterial agent, 0.1 to 2 parts of disodium EDTA, and the balance is deionized water.

[0006] In some embodiments of the present invention, the molecular weight of the sphingomonas fermentation product extract is 4×10 5 Da~6×10 5 Da.

[0007] In some embodiments of the present invention, the Sphingomonas fermentation product extract comprises linear tetrasaccharide repeating units, wherein the tetrasaccharide repeating units comprise β(1→3)-D-glucose, β(1→4)-D-glucuronic acid, β(1→4)-D-glucose and α(1→4)-L-rhamnose.

[0008] In some embodiments of the present invention, the molar ratio of the β(1→3)-D-glucose, the β(1→4)-D-glucuronic acid, the β(1→4)-D-glucose and the α(1→4)-L-rhamnose is 1:1:1:1.

[0009] In some embodiments of the present invention, the sugar nucleotide precursors of the Sphingomonas fermentation product extract include UDP-D-glucose, UDP-D-glucuronic acid and dTDP-L-rhamnose.

[0010] In some embodiments of the present invention, the antibacterial agent comprises a liquid mixture of phenoxyethanol and chlorphenesin, wherein the mass ratio of phenoxyethanol to chlorphenesin is (1-5):1.

[0011] In some embodiments of the present invention, the emulsifier includes at least one of pentaerythritol stearate, pentaerythritol decanoate, pentaerythritol octanoate, and pentaerythritol adipate.

[0012] The second aspect of the present invention provides a method for preparing a sphingomonas fermentation product extract composition, comprising the following steps:

[0013] S1. preparing an extract of a fermentation product of Sphingomonas sphingomonas;

[0014] S2, adding deionized water into an emulsifying pot, heating to 38° C. to 50° C., adding lactic acid, disodium EDTA and the sphingomonas fermentation product extract in sequence under stirring, and continuously stirring until completely dissolved to form an aqueous phase mixture;

[0015] S3, mixing methyl glucose polyether-20, glycerin and emulsifier, heating to 75° C. to 80° C., adding phytosphingosine while stirring, and continuing to stir until completely dissolved to form an oil phase mixture;

[0016] S4. Slowly add the oil phase mixture into an emulsifying pot while homogenizing, and gradually lower the temperature to 40° C. to 45° C., add an antibacterial agent, stir and cool to room temperature, and let stand for 0.5 to 1 hour to obtain a sphingobacterium fermentation product extract composition.

[0017] In some embodiments of the present invention, step S1 comprises: inoculating Sphingosine monocellular bacteria into a culture medium containing UDP-D-glucose, UDP-D-glucuronic acid, dTDP-L-rhamnose, a nitrogen source and an inorganic salt, adjusting the pH value of the culture medium to 6.8-7.2, and fermenting with aeration and stirring at 30°C for 18 hours to 24 hours. After the fermentation is completed, the fermentation broth is centrifuged to obtain the supernatant to obtain a Sphingosine monocellular bacteria fermentation product extract.

[0018] In some embodiments of the present invention, in step S4, the homogenization speed is 3000 rpm to 5000 rpm, and the homogenization time is 5 minutes to 15 minutes.

[0019] The beneficial effects that can be achieved by the present invention are:

[0020] The present invention provides a composition of extracts of sphingosine fermentation products, wherein the plant sphingosine and sphingosine fermentation product extracts have moisturizing effects and can be used in combination with other active ingredients such as vitamins, antioxidants, anti-ultraviolet agents, etc., and have good compatibility with a variety of functional ingredients. Methyl glucose polyether-20 synergizes with an emulsifier to form a stable emulsified system, so that each component is evenly dispersed, the oil loading is increased, the needs of different formulas are met, and its application range in the fields of skin care, sun protection, and beauty is expanded. At the same time, the addition of lactic acid can not only adjust the pH value of the product, making it closer to the natural pH environment of human skin, improving the mildness and skin absorbability of the product, but also has a certain buffering effect, so that the product remains stable in a wider pH range and adapts to different use conditions. DETAILED DESCRIPTION

[0021] The following description is provided for those skilled in the art to fully understand the present invention, and is not intended to limit the subject matter described in the claims.

[0022] The "range" disclosed in the present invention is defined in the form of a lower limit and an upper limit, and a given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundaries of the particular range. The range defined in this way can be inclusive or exclusive of the end values, and can be arbitrarily combined, that is, any lower limit can be combined with any upper limit to form a range. For example, if a range of 60 to 120 and 80 to 110 is listed for a particular parameter, it is understood that a range of 60 to 110 and 80 to 120 is also expected. In addition, if the minimum range values ​​1 and 2 are listed, and if the maximum range values ​​3, 4 and 5 are listed, the following ranges can all be expected: 1 to 3, 1 to 4, 1 to 5, 2 to 3, 2 to 4 and 2 to 5. In the present invention, unless otherwise specified, the numerical range "a to b" represents an abbreviation of any real number combination between a and b, wherein a and b are both real numbers. For example, the numerical range "0-5" means that all real numbers between "0-5" are listed in this document, and "0-5" is just an abbreviation of these numerical combinations. In addition, when a parameter is expressed as an integer ≥ 2, it is equivalent to disclosing that the parameter is, for example, an integer of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.

[0023] If not otherwise specified, all embodiments and optional embodiments of the present invention can be combined with each other to form a new technical solution.

[0024] Unless otherwise specified, all technical features and optional technical features of the present invention can be combined with each other to form a new technical solution.

[0025] If not otherwise specified, all steps of the present invention may be performed sequentially or randomly, preferably sequentially. For example, the method includes steps (a) and (b), which means that the method may include steps (a) and (b) performed sequentially, or may include steps (b) and (a) performed sequentially. For example, the method may further include step (c), which means that step (c) may be added to the method in any order, for example, the method may include steps (a), (b) and (c), or may include steps (a), (c) and (b), or may include steps (c), (a) and (b), etc.

[0026] In the development of modern cosmetics and personal care products, consumers have higher requirements for the naturalness, mildness and efficacy of products. Although traditional synthetic chemical ingredients can provide certain efficacy, their potential irritation and environmental impact are increasingly concerned. Therefore, the development of new compositions based on natural plant extracts and microbial fermentation products has become a trend in the industry.

[0027] As a natural polysaccharide with multiple biological activities, sphingosine gum can be used as a carrier in skin care, sun protection, and cosmetics to carry functional ingredients and achieve different skin care purposes. However, there is currently a lack of a sphingosine monocellular bacteria fermentation product extract composition with strong compatibility, high stability, wide pH platform, high oil loading, long-lasting moisturizing, and refreshing skin feel.

[0028] In view of this, the present invention proposes a sphingosine monocyte fermentation product extract composition, which includes, by weight: 0.5 to 5 parts of phytosphingosine, 0.3 to 3 parts of sphingosine monocyte fermentation product extract, 1 to 5 parts of methyl glucose polyether-20, 0.01 to 0.5 parts of lactic acid, 3 to 7 parts of glycerol, 10 to 20 parts of emulsifier, 0.5 to 1 part of antibacterial agent, 0.1 to 2 parts of disodium EDTA, and the balance is deionized water.

[0029] Phytosphingosine and extracts of sphingosine fermentation products have moisturizing effects and can be used in combination with other active ingredients such as vitamins, antioxidants, and anti-ultraviolet agents. They have good compatibility with a variety of functional ingredients. Methyl glucose polyether-20 works synergistically with emulsifiers to form a stable emulsification system, which evenly disperses the ingredients, increases the oil loading, meets the needs of different formulas, and expands its application in skin care, sun protection, beauty and other fields. At the same time, the addition of lactic acid can not only adjust the pH value of the product to make it closer to the natural pH environment of human skin, improve the mildness and skin absorbability of the product, but also has a certain buffering effect, so that the product remains stable in a wider pH range and adapts to different usage conditions.

[0030] The extract composition of the fermentation product of Sphingobacterium sphingosum of the present solution can provide a lasting moisturizing effect on the skin surface, and has good ductility and absorbency, bringing a refreshing and comfortable use experience.

[0031] In some embodiments, the molecular weight of the Sphingomonas fermentation product extract is 4×10 5 Da~6×10 5 Da.

[0032] Extracts with larger molecular weights are generally more stable, less susceptible to environmental factors, and more biologically active, such as better antioxidant and anti-inflammatory effects, and can better penetrate into the deep layers of the skin to exert the moisturizing, anti-aging and repair effects of the added active ingredients. Despite its large molecular weight, the fermentation product extract of Sphingomonas has good solubility. This allows it to be better dispersed evenly when mixed with other ingredients.

[0033] In some embodiments, the Sphingomonas fermentation product extract comprises linear tetrasaccharide repeating units comprising β(1→3)-D-glucose, β(1→4)-D-glucuronic acid, β(1→4)-D-glucose, and α(1→4)-L-rhamnose.

[0034] The four glycogenins serve as a linear main chain, so that the extract of the fermentation product of Sphingomonas sphingomonas has low charge density, low charge repulsion and high molecular weight, and can increase the stability of the composition system.

[0035] In some embodiments, the molar ratio of the β(1→3)-D-glucose, the β(1→4)-D-glucuronic acid, the β(1→4)-D-glucose and the α(1→4)-L-rhamnose is 1:1:1:1. Due to the uniform distribution of various monosaccharides in the polysaccharide chain, the extract has good moisturizing properties. It can effectively absorb and lock moisture, providing a long-lasting moisturizing effect for skin or other applications.

[0036] In some embodiments, the sugar nucleotide precursors of the Sphingomonas fermentation product extract include UDP-D-glucose, UDP-D-glucuronic acid, and dTDP-L-rhamnose.

[0037] In some embodiments, the antibacterial agent includes a liquid mixture of phenoxyethanol and chlorphenesin, wherein the mass ratio of phenoxyethanol to chlorphenesin is (1-5):1. Chlorphenesin does not contain any organic or combined formaldehyde, and has good local skin or mucous membrane tolerance. Phenoxyethanol also has good skin tolerance. This compound antibacterial agent is used in cosmetics and other products that come into contact with the skin to reduce irritation and adverse reactions to the skin. In some embodiments, the mass ratio of phenoxyethanol to chlorphenesin is 4:1.

[0038] In some embodiments, the emulsifier includes at least one of pentaerythritol stearate, pentaerythritol decanoate, pentaerythritol octanoate, and pentaerythritol adipate. Pentaerythritol stearate, pentaerythritol decanoate, pentaerythritol octanoate, and pentaerythritol adipate as emulsifiers have good emulsifying properties, stability, and safety.

[0039] The second aspect of the present invention provides a method for preparing a sphingomonas fermentation product extract composition, comprising the following steps:

[0040] S1. preparing an extract of a fermentation product of Sphingomonas sphingomonas;

[0041] S2, adding deionized water into an emulsifying pot, heating to 38° C. to 50° C., adding lactic acid, disodium EDTA and the sphingomonas fermentation product extract in sequence under stirring, and continuously stirring until completely dissolved to form an aqueous phase mixture;

[0042] S3, mixing methyl glucose polyether-20, glycerin and emulsifier, heating to 75° C. to 80° C., adding phytosphingosine while stirring, and continuing to stir until completely dissolved to form an oil phase mixture;

[0043] S4. Slowly add the oil phase mixture into an emulsifying pot while homogenizing, and gradually lower the temperature to 40° C. to 45° C., add an antibacterial agent, stir and cool to room temperature, and let stand for 0.5 to 1 hour to obtain a sphingobacterium fermentation product extract composition.

[0044] In this scheme, the oil phase mixture is slowly added to the emulsifier while homogenizing, so that the oil and water phases are fully mixed to form a uniform emulsified system, thereby improving the stability of the product. Before adding the antibacterial agent, the temperature is lowered to 40°C to 45°C, which is beneficial to the stability and effectiveness of the antibacterial agent and avoids high temperature from destroying the activity of the antibacterial agent. After stirring and cooling to room temperature, it is allowed to stand for 0.5 to 1 hour to further stabilize the ingredients in the product and form a uniform sphingosine bacteria gum composition.

[0045] In some embodiments, step S1 includes: inoculating Sphingosine monocellular bacteria into a culture medium containing UDP-D-glucose, UDP-D-glucuronic acid, dTDP-L-rhamnose, a nitrogen source and an inorganic salt, adjusting the pH value of the culture medium to 6.8-7.2, and performing aeration and stirring fermentation at 30°C for 18 hours to 24 hours. After the fermentation is completed, the fermentation liquid is centrifuged to obtain the supernatant to obtain a Sphingosine monocellular bacteria fermentation product extract. The fermentation is carried out at 30°C for 18 hours to 24 hours with aeration and stirring. 30°C is a suitable growth temperature for Sphingosine monocellular bacteria, which is conducive to its rapid reproduction and metabolic activities. Ventilation and stirring can provide sufficient oxygen to promote aerobic fermentation process. At the same time, stirring helps to evenly mix the fermentation liquid, so that the microorganisms are fully in contact with nutrients and improve the fermentation efficiency.

[0046] During the fermentation process, Sphingomonas can secrete a variety of extracellular products, such as glycosphingolipids, gellan gum, etc. These ingredients have the effects of moisturizing, improving rough skin, promoting skin cell proliferation and migration, and delaying cell aging.

[0047] In some embodiments, in step S4, the homogenization speed is 3000 rpm to 5000 rpm, and the homogenization time is 5 minutes to 15 minutes. If the homogenization time is too long, the emulsion droplets may be too small, the viscosity of the emulsified system may be increased, and the fluidity and use effect of the product may be affected.

[0048] The technical solution of the present invention is further described in detail below in conjunction with specific embodiments. It should be understood that the following specific embodiments are only used to explain the present invention, and are not used to limit the present invention.

[0049] Example 1

[0050] S1. Inoculate Sphingomonas sphingomonas into a culture medium containing UDP-D-glucose, UDP-D-glucuronic acid, dTDP-L-rhamnose, a nitrogen source and an inorganic salt, adjust the pH value of the culture medium to 6.8-7.2, and perform aeration and stirring fermentation at 30°C for 20 hours. After the fermentation is completed, centrifuge the fermentation broth to obtain the supernatant to obtain a Sphingomonas sphingomonas fermentation product extract, which has a linear tetrasaccharide repeating unit, and the molar ratio of β(1→3)-D-glucose, β(1→4)-D-glucuronic acid, β(1→4)-D-glucose and α(1→4)-L-rhamnose is 1:1:1:1, and the molecular weight is 5×10 5 Da;

[0051] S2. Add 65 parts of deionized water into an emulsifying pot, heat to 42° C., and add 0.1 parts of lactic acid, 0.1 parts of disodium EDTA and 0.5 parts of sphingomonas fermentation product extract in parts by weight in a stirring state, and continue stirring until completely dissolved to form an aqueous phase mixture;

[0052] S3, 2 parts of methyl glucose polyether-20, 5 parts of glycerol and 10 parts of pentaerythritol stearate are mixed, heated to 75° C. to 80° C., and 2 parts of phytosphingosine are added under stirring, and stirring is continued until completely dissolved to form an oil phase mixture;

[0053] S4. Slowly add the oil phase mixture into an emulsifying pot while homogenizing at a speed of 3000 rpm for 10 minutes, gradually lower the temperature to 40°C to 45°C, add 0.6 parts of a mixture of phenoxyethanol and chlorphenesin in a mass ratio of 5:1, stir and cool to room temperature, let stand for 0.5 to 1 hour, and obtain a sphingobacterium fermentation product extract composition.

[0054] Example 2

[0055] The composition of the extract of the fermentation product of Sphingosine monocellular bacteria comprises, in parts by weight, 3 parts of phytosphingosine, 1 part of the extract of the fermentation product of Sphingosine monocellular bacteria, 2 parts of methyl glucose polyether-20, 0.05 parts of lactic acid, 3 parts of glycerol, 10 parts of pentaerythritol stearate, 0.5 parts of phenoxyethanol, 0.1 parts of chlorphenesin, 0.1 parts of disodium EDTA, and 65 parts of deionized water. For the rest, refer to Example 1.

[0056] Comparative Example 1

[0057] No Sphingomonas fermentation product extract was added, and the rest was as in Example 1.

[0058] Comparative Example 2

[0059] No phytosphingosine was added, and the rest was as in Example 1.

[0060] Performance Test:

[0061] The safety performance, viscosity, stability, pH value, and moisturizing effect of the sphingomonas fermentation product extract composition obtained in the examples and comparative examples were measured, and the results were recorded in Table 1:

[0062] 1. Safety performance

[0063] With reference to the fifth part of the human skin occluded patch test method of the "Technical Specification for Safety of Cosmetics" (2015 edition), 30 volunteers were selected and the occluded patch tests were carried out simultaneously on the samples of the above embodiments and comparative examples.

[0064] 2. Viscosity

[0065] The viscosity is calculated by measuring the shear stress and shear rate during rotation at a constant temperature of 37°C.

[0066] 3. Stability:

[0067] RT (room temperature) testing evaluates the stability of a product under normal storage conditions by placing the sample at room temperature (usually 25°C) for 1 month. The sample's physical properties such as appearance, color, and odor are checked.

[0068] The 50℃ 1 month test simulates the accelerated aging process under high temperature conditions to evaluate the thermal stability of the product. The samples are placed in a constant temperature box, set at 50℃, maintained for 1 month, and the physical properties of the samples, such as color, delamination, etc., are checked.

[0069] The freeze-thaw cycle 5 test evaluates the stability of the product under repeated freeze-thaw conditions, simulating the use under extreme climate conditions. Place the sample in a freezer, set the temperature to -20°C, and freeze for 4 hours. Take out the sample, put it in a constant temperature water bath, set the temperature to 20°C, and thaw for 4 hours. Repeat the above freeze-thaw process 5 times, and then check the physical properties, color, stratification, etc. of the sample.

[0070] The extract compositions of the fermentation products of Sphingomonas sphingomonas in the examples and comparative examples were loaded with 1% by weight of commercially available color powder, and the above freeze-thaw cycle test was repeated.

[0071] 4. Moisturizing effect

[0072] According to QB / T 4256-2011 Cosmetic Moisturizing Efficacy Evaluation Guide, 20 testers were selected for each sample, and the samples in each embodiment and comparative example were quantitatively applied to the circled area of ​​the forearm. The instrument MOISTURE METERS CMSC1212 (DELFIN) and the instrument TAPOMETER SWL5167 (DELFIN) were used to measure the hydration content of the skin stratum corneum 2h and 8h after using the sample, and the average value was calculated.

[0073] Table 1: Test results of Examples 1-2 and Comparative Examples 1-2

[0074]

[0075]

[0076] It can be seen from Table 1 that no allergic phenomena such as skin redness or erythema were observed in the embodiments of the present invention, which shows that the compositions prepared in the embodiments of the present invention are safe and do not cause any adverse phenomena.

[0077] The viscosity of Example 2 is the highest, which is due to the synergistic effect of phytosphingosine and the extract of the fermentation product of Sphingobacteria, which enhances the viscosity. The viscosity of Comparative Example 2 is the lowest, indicating that phytosphingosine has a significant contribution to the viscosity in the emulsified system.

[0078] There was no abnormality in Examples 1 and 2 during the 50°C stability test, indicating that they could remain stable under high temperature conditions. The stratification of Comparative Examples 1 and 2 was due to the instability of the emulsified system caused by the lack of the extract of the fermentation product of Sphingomonas sphingosine or phytosphingosine.

[0079] Examples 1 and 2 showed no abnormalities after freeze-thaw cycles, showing good anti-freeze-thaw performance. Comparative Examples 1 and 2 showed stratification, and Comparative Example 2 also showed powder precipitation, which further demonstrated that the synergistic effect of phytosphingosine and the extract of the fermentation product of Sphingosine Monocellular Bacteria played an important role in the stability of the emulsified system.

[0080] The stratum corneum hydration content of Examples 1 and 2 at 2 hours and 8 hours was higher than that of Comparative Examples 1 and 2, which proves that the sphingosine gum composition has a good moisturizing effect and can effectively improve the hydration level of the skin.

[0081] Based on the above performance, the plant sphingosine and sphingosine fermentation product extracts in the sphingosine fermentation product extract composition of this scheme have a moisturizing effect, and are conducive to compounding with other active ingredients such as vitamins, antioxidants, anti-ultraviolet agents, etc., and have good compatibility with a variety of functional ingredients. Methyl glucose polyether-20 works synergistically with the emulsifier to form a stable emulsification system, so that the various ingredients are evenly dispersed, the oil loading is increased, the needs of different formulas are met, and its application range in skin care, sun protection, beauty and other fields is expanded. At the same time, the addition of lactic acid can not only adjust the pH value of the product, making it closer to the natural pH environment of human skin, improving the mildness and skin absorbability of the product, but also has a certain buffering effect, so that the product remains stable in a wider pH range and adapts to different use conditions.

[0082] It should be noted that the present invention is not limited to the above-mentioned embodiments. The above-mentioned embodiments are only examples, and the embodiments having the same structure as the technical idea and exerting the same effect within the scope of the technical solution of the present invention are all included in the technical scope of the present invention. In addition, without departing from the scope of the main purpose of the present invention, various modifications that can be thought of by those skilled in the art to the embodiments and other methods of combining some of the constituent elements in the embodiments are also included in the scope of the present invention.

Claims

1. A composition of a sphingomonas fermentation product extract, characterized in that: In parts by weight, it includes: 0.5-5 parts of phytosphingosine, 0.3-3 parts of Sphingomonas fermentation product extract, 1-5 parts of methyl glucose polyether-20, 0.01-0.5 parts of lactic acid, 3-7 parts glycerin, 10-20 parts of emulsifier, 0.5-1 part antibacterial agent, 0.1-2 parts of disodium EDTA, The balance was deionized water.

2. The composition of the sphingomonas fermentation product extract according to claim 1, characterized in that: The molecular weight of the sphingosine monocellular bacteria fermentation product extract is 4×10 5 Da~6×10 5 Da.

3. The composition of the sphingomonas fermentation product extract according to claim 1, characterized in that: The sphingomonas fermentation product extract comprises linear tetrasaccharide repeating units, wherein the tetrasaccharide repeating units comprise β(1→3)-D-glucose, β(1→4)-D-glucuronic acid, β(1→4)-D-glucose and α(1→4)-L-rhamnose.

4. The composition of the extract of the fermentation product of Sphingomonas spp. according to claim 3, characterized in that: The molar ratio of the β(1→3)-D-glucose, the β(1→4)-D-glucuronic acid, the β(1→4)-D-glucose and the α(1→4)-L-rhamnose is 1:1:1:

1.

5. The composition of the extract of the fermentation product of Sphingomonas spp. according to claim 1, characterized in that: The sugar nucleotide precursors of the sphingomonas fermentation product extract include UDP-D-glucose, UDP-D-glucuronic acid and dTDP-L-rhamnose.

6. The composition of the sphingomonas fermentation product extract according to claim 1, characterized in that: The antibacterial agent comprises a liquid mixture of phenoxyethanol and chlorphenesin, wherein the mass ratio of phenoxyethanol to chlorphenesin is (1-5):

1.

7. The composition of the sphingomonas fermentation product extract according to claim 1, characterized in that: The emulsifier includes at least one of pentaerythritol stearate, pentaerythritol decanoate, pentaerythritol octanoate and pentaerythritol adipate.

8. A method for preparing a composition of an extract of a sphingomonas fermentation product according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1. preparing an extract of a fermentation product of Sphingomonas sphingomonas; S2, adding deionized water into an emulsifying pot, heating to 38° C. to 50° C., adding lactic acid, disodium EDTA and the sphingomonas fermentation product extract in sequence under stirring, and continuously stirring until completely dissolved to form an aqueous phase mixture; S3, mixing methyl glucose polyether-20, glycerin and emulsifier, heating to 75° C. to 80° C., adding phytosphingosine while stirring, and continuing to stir until completely dissolved to form an oil phase mixture; S4. Slowly add the oil phase mixture into an emulsifying pot while homogenizing, and gradually lower the temperature to 40° C. to 45° C., add an antibacterial agent, stir and cool to room temperature, and let stand for 0.5 to 1 hour to obtain a sphingobacterium fermentation product extract composition.

9. The method for preparing the sphingomonas fermentation product extract composition according to claim 8, characterized in that: Step S1 comprises: inoculating sphingomonas into a culture medium containing UDP-D-glucose, UDP-D-glucuronic acid, dTDP-L-rhamnose, a nitrogen source and an inorganic salt, adjusting the pH value of the culture medium to 6.8-7.2, performing aeration and stirring fermentation at 30° C. for 18 hours to 24 hours, and after the fermentation is completed, centrifuging the fermentation liquid to obtain the supernatant to obtain a sphingomonas fermentation product extract.

10. The method for preparing the sphingomonas fermentation product extract composition according to claim 8, characterized in that: In step S4, the homogenization speed is 3000 rpm to 5000 rpm, and the homogenization time is 5 minutes to 15 minutes.

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