A deeply nourishing hair conditioner and its preparation method

Abstract

The present application provides a deeply nourishing hair conditioner and a preparation method thereof, belonging to the field of hair conditioners. The hair conditioner is composed of the following chemical components: quaternized sodium alginate: 2-4%, polyquaternium: 1-3%, phosphorylated wheat protein: 1-3%, polyethylene glycol-150 distearate: 0.5-2%, temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes: 5-6%, polyaniline nanofiber composite conductive microplates: 0.1-0.3%, glucosylglycerol: 1.5-2.5%, acetylated hyaluronic acid: 0.5-1.5%, pH regulator ≤0.2%, emulsifier: 1-3%, thickener: 7-9%, lubricant: 2-4%, preservative: 0.5-0.7%, fragrance 0.3-0.5%, and the balance is deionized water. The hair conditioner achieves a full-dimensional hair care effect from surface protection to deep repair.

Description

Technical Field

[0001] This application relates to the technical field of hair conditioners, and particularly to a deeply nourishing hair conditioner and its preparation method. Background Art

[0002] The main function of hair conditioner is to protect and nourish hair, help repair hair quality, and make hair smoother and more lustrous. With the upgrading of consumers' functional requirements for hair care products, traditional hair conditioners are gradually showing technical bottlenecks in repairing damage caused by perming and dyeing, improving dry and frizzy hair, etc.

[0003] In the prior art, hair conditioners mainly neutralize the negative charges of hair through cationic surfactants (such as quaternary ammonium salts) to reduce static electricity, and rely on silicone oil components to enhance smoothness. However, such formulations have the following defects: traditional cationic conditioners (such as polyquaternium-10) are prone to excessive deposition on the hair surface, resulting in stiff hair strands, sticky touch, and incompatibility with anionic moisturizing components (such as hydrolyzed protein), which is prone to cause flocculation; conventional moisturizers (such as hyaluronic acid) are difficult to penetrate the hair cuticle due to their too large molecular weight (>100 kDa), and can only form a water-locking film on the surface, unable to penetrate deep into the cortex to repair keratin fractures; existing liposome or microcapsule technologies are mostly single-responsive (temperature or pH), unable to match hair care scenarios (such as hair drying and heating, slightly acidic scalp environment), resulting in an active ingredient release rate of less than 60%. Therefore, in view of the need to repair damaged hair caused by perming and dyeing, there is an urgent need in the market for a hair conditioner that can break through the surface action and achieve full-dimensional coordination of "softening - moisturizing - repairing", especially to solve the problems of intelligent release, deep penetration, and long-term maintenance of active ingredients. Summary of the Invention

[0004] This application provides a deeply nourishing hair conditioner and its preparation method to achieve a hair conditioner with full-dimensional coordination of "softening - moisturizing - repairing", especially to solve the problems of intelligent release, deep penetration, and long-term maintenance of active ingredients.

[0005] In the first aspect, this application provides a deeply nourishing hair conditioner. Calculated by mass fraction, the hair conditioner is composed of the following chemical components: quaternized sodium alginate: 2 - 4%, polyquaternium: 1 - 3%, phosphorylated wheat protein: 1 - 3%, polyethylene glycol-150 distearate: 0.5 - 2%, temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid)-coated liposome: 5 - 6%, polyaniline nanofiber composite conductive microplate: 0.1 - 0.3%, glucosylglycerol: 1.5 - 2.5%, acetylated hyaluronic acid: 0.5 - 1.5%, pH regulator ≤0.2%, emulsifier: 1 - 3%, thickener: 7 - 9%, lubricant: 2 - 4%, preservative: 0.5 - 0.7%, fragrance: 0.3 - 0.5%, and the balance is deionized water;

[0006] The liposomes of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes encapsulate keratin peptides and tea tree oil;

[0007] The polyaniline nanofiber composite conductive micro-sheet contains a polyethylene glycol-poly(lactic acid) coating layer.

[0008] Optionally, the quaternization substitution degree of the quaternized sodium alginate ranges from 60% to 80%, and the molecular weight is from 500,000 to 800,000 Da;

[0009] The polyquaternium is polyquaternium-67, and the cationic charge density is 0.8 - 1.2 meq / g;

[0010] The phosphorylation substitution degree of the phosphorylated wheat protein is ≥15%, and the molecular weight is from 10 to 30 kDa;

[0011] The HLB value of polyethylene glycol-150 distearate is 8 - 10.

[0012] Optionally, the liposomes of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes have a particle size of 80 - 120 nm, the coating layer thickness is 8 - 15 nm, and the mass ratio of the keratin peptides and tea tree oil encapsulated in the liposomes is (1 - 3):1.

[0013] Optionally, the nanofibers of the polyaniline nanofiber composite conductive micro-sheet have a diameter of 50 - 80 nm, a length of 1 - 3 μm, a conductivity ≥20 S / cm, and the polyethylene glycol-poly(lactic acid) coating layer thickness is 200 - 500 nm.

[0014] Optionally, the pH regulator is citric acid or lactic acid;

[0015] The emulsifier is PEG-40 hydrogenated castor oil;

[0016] The thickener is composed of xanthan gum and magnesium aluminum silicate, and the mass ratio of the xanthan gum and the magnesium aluminum silicate is 1:(1 - 3);

[0017] The lubricant is dimethyl silicone oil;

[0018] The preservative is composed of phenoxyethanol and ethylhexylglycerin, and the mass ratio of the phenoxyethanol and the ethylhexylglycerin is 1:(1 - 3);

[0019] The fragrance is natural plant essential oil encapsulated by β-cyclodextrin.

[0020] In a second aspect, the present application provides a method for preparing the deeply nourishing hair conditioner according to any one of the embodiments in the first aspect, and the method includes:

[0021] Obtaining each raw material of the hair conditioner;

[0022] Under stirring, add the quaternized sodium alginate, the glycerol glucoside, the acetylated hyaluronic acid, the polyquaternium and the phosphorylated wheat protein into deionized water at a set temperature, and keep warm to obtain an aqueous phase mixture;

[0023] Heat the polyethylene glycol-150 distearate, the emulsifier and the lubricant to a molten state to obtain an oil phase mixture;

[0024] Perform high-speed homogenization on the aqueous phase mixture and the oil phase mixture, and add a thickening agent to obtain a first emulsion mixture;

[0025] Add the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes and the polyaniline nanofiber composite conductive microsheets to the first emulsion mixture to obtain a second emulsion mixture;

[0026] Add the pH regulator, the preservative and the fragrance to the second emulsion mixture to obtain the hair conditioner.

[0027] Optionally, the pressure of the high-speed homogenization treatment is 5000-8000 psi, the number of cycles is 3-5 times, and the particle size of the emulsion after homogenization is ≤5 μm.

[0028] Optionally, the preparation method of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes includes:

[0029] Add linseed oil, lecithin and cholesterol into chloroform, and then perform rotary evaporation to obtain a lipid film;

[0030] Dissolve keratin peptides and tea tree oil in phosphate buffer to obtain a hydrated solution;

[0031] Under a nitrogen atmosphere, add the hydrated solution to the lipid film, and then perform high-pressure homogenization to obtain liposomes;

[0032] Under stirring, add the liposomes to a copolymer solution of N-isopropylacrylamide and acrylic acid to enable the copolymer to self-assemble on the surface of the liposomes to obtain the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes.

[0033] Optionally, the mass ratio of the linseed oil, the lecithin and the cholesterol is 7:(1-3):1;

[0034] The mass concentration of the keratin peptides is 1-3%, and the mass concentration of the tea tree oil is 0.5-1.5%;

[0035] The molar ratio of the N-isopropylacrylamide to the acrylic acid is 85:15;

[0036] The mass ratio of the liposome to the copolymer is 5:1.

[0037] Optionally, the method for preparing the polyaniline nanofiber composite conductive micro-sheet includes:

[0038] Mixing polyaniline nanofiber powder, polyethylene glycol-polylactic acid, and dichloromethane to obtain a spinning solution; the mass concentration of the polyethylene glycol-polylactic acid in the spinning solution is 1-3%, and the mass ratio of the polyaniline nanofiber powder to the polyethylene glycol-polylactic acid is (1-3):1;

[0039] Electrospinning the spinning solution and then performing a crushing treatment to form a polyethylene glycol-polylactic acid coating layer with a set thickness on the surface of the polyaniline nanofibers, thereby obtaining the polyaniline nanofiber composite conductive micro-sheet; the voltage of the electrospinning is 18-20 kV, the advancing rate is 0.7-0.9 mL / h, and the receiving distance is 10 cm.

[0040] The above technical solution provided by the embodiments of the present application has the following advantages compared with the prior art:

[0041] The present application provides a deeply nourishing hair conditioner, which rationally designs the chemical components of the hair conditioner and has a multi-dimensional synergistic mechanism. First, the charge gradient is designed as quaternized sodium alginate (+15 mV) → polyquaternium-67 (+5 mV) → phosphorylated wheat protein (-25 mV) to form a Zeta potential gradient. Thereby reducing the stiffness of the hair caused by excessive cation adsorption, and at the same time constructing a "softening-moisturizing" composite network through electrostatic crosslinking. Second, when blowing hair or heating the environment to 40°C, the liposome releases keratin peptides to repair the cortex. At the same time, the weak acidic environment (pH 5.5) of the scalp releases tea tree oil to inhibit Malassezia (inhibition rate ≥ 99%). In addition, the microcurrent of the conductive micro-sheet drives the migration of charged components. Finally, glucosylglycerol quickly penetrates to replenish water, and acetylated hyaluronic acid locks water to form a film. At the same time, keratin peptides fill the defects of the hair cuticle, and the crosslinking density of disulfide bonds is increased. Thus, a hair conditioner with "softening-moisturizing-repair" full-dimensional synergy is realized, especially solving the problems of intelligent release, deep penetration, and long-term maintenance of active ingredients. Description of the Drawings

[0042] The drawings here are incorporated into the specification and form a part of this specification, showing the embodiments that conform to the present application, and are used together with the specification to explain the principle of the present application.

[0043] To more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the accompanying drawings required for the description of the embodiments or the prior art. Obviously, for those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0044] Figure 1 It is a schematic flow chart of the preparation method of the deeply nourishing hair conditioner provided by the embodiment of the present application. Specific embodiments

[0045] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are some but not all of the embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present application without creative efforts fall within the scope of protection of the present application.

[0046] Unless otherwise specifically stated, all kinds of raw materials, reagents, instruments and equipment used in the present application can be obtained through market purchase or can be prepared by existing methods.

[0047] In the first aspect, the present application provides a deeply nourishing hair conditioner. Calculated by mass fraction, the hair conditioner is composed of the following chemical components: quaternized sodium alginate: 2-4%, polyquaternium: 1-3%, phosphorylated wheat protein: 1-3%, polyethylene glycol-150 distearate: 0.5-2%, temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposome: 5-6%, polyaniline nanofiber composite conductive microplate: 0.1-0.3%, glucosylglycerol: 1.5-2.5%, acetylated hyaluronic acid: 0.5-1.5%, pH regulator ≤ 0.2%, emulsifier: 1-3%, thickener: 7-9%, lubricant: 2-4%, preservative: 0.5-0.7%, fragrance: 0.3-0.5%, and the balance is deionized water;

[0048] The liposome of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposome encapsulates keratin peptides and tea tree oil;

[0049] The polyaniline nanofiber composite conductive microplate contains a polyethylene glycol-polylactic acid coating layer.

[0050] This hair conditioner realizes a full-dimensional hair care effect from surface protection to deep repair through charge gradient design, intelligent release mechanism, conductive enhanced penetration and moisturizing repair linkage. Each component acts synergistically at the molecular level, breaking through the single-effect limitation of traditional formulations, and is especially suitable for hair quality problems such as permed and dyed damage, dryness and frizz.

[0051] The functions of each chemical component are as follows:

[0052] (1) Quaternized sodium alginate (2-4%): through the quaternary ammonium group (-N + (CH3)3) and the negative charge of the hair cuticle (-COO - ) electrostatically bonded to form a continuous protective film, reducing the curling of hair scales and reducing the friction coefficient to below 0.55. At the same time, the polyhydroxy structure of the sodium alginate main chain absorbs water through hydrogen bonds, increasing the water content of hair (48h water retention rate ≥ 85%). In addition, the high molecular weight (500,000-800,000 Da) ensures the density of the film layer, prevents water evaporation, and provides a smooth surface for subsequent active ingredient penetration.

[0053] (2) Polyquaternium-67 (1-3%): The quaternary ammonium groups in the molecular chain are spaced far apart (charge density 0.8-1.2 meq / g), which prevents hair from becoming stiff due to excessive adsorption and forms a charge gradient with quaternized sodium alginate. At the same time, hydrophobic segments (such as long-chain alkyl groups) are embedded in the gaps of the hair scales to fill the gaps. Together with quaternized sodium alginate, a "high charge-low charge" gradient is formed to optimize the balance between softness and antistatic properties.

[0054] (3) Phosphorylated wheat protein (1-3%): phosphate group (-PO4³ - ) is electrostatically cross-linked with cationic components (quaternary ammonium salts) to form a three-dimensional network to lock in moisture. At the same time, the low molecular weight (10-30 kDa) allows it to penetrate the gaps between hair scales and replenish cortical keratin (repair rate ≥ 70%). Phosphorylation enhances hydrophilicity and forms a dual-effect structure of "outer layer moisture locking-inner layer repair" with the cationic membrane layer.

[0055] (4) Polyethylene glycol-150 distearate (0.5-2%): The nonionic PEG chain isolates cations (quaternary ammonium salts) and anions (phosphorylated proteins) to prevent flocculation. At the same time, the HLB value of 8-10 balances the oil-water compatibility and ensures that the liposomes and conductive microsheets are evenly dispersed (centrifugal stability > 95%). As a "charge buffer", it ensures the long-term stability of the multi-charged components in the formula.

[0056] (5) Temperature-controlled poly(NIPAM-co-AA)-coated liposomes (5-6%): The LCST (lowest critical solution temperature) property of polyNIPAM causes the liposome membrane to shrink at the temperature of hair drying, releasing keratin peptides. At the same time, the carboxyl group of acrylic acid is protonated in a weakly acidic environment, the membrane permeability increases, and tea tree oil is released. The dual-trigger release precisely matches the hair care scenario (heating caused by hair drying + slightly acidic scalp), and keratin peptides penetrate deep into the cortex to repair disulfide bonds.

[0057] (6)Polyaniline nanofiber composite conductive microflakes (0.1 - 0.3%): Conductive microflakes (conductivity ≥ 20 S / cm) form an electric potential gradient under a microcurrent (0.5 mA), driving charged components (such as keratin peptides) to migrate to the cortex. At the same time, local heating (ΔT ≈ 5 °C) accelerates the release of liposomes, synergistically enhancing the repair efficiency by 40%. The PEG-PLA coating layer (200 - 500 nm) prevents fiber oxidation and enhances compatibility with the conditioner matrix.

[0058] (7)Glucosylglycerol (1.5 - 2.5%) + acetylated hyaluronic acid (0.5 - 1.5%): Small molecule glucosylglycerol rapidly penetrates into the gaps between the hair cuticles and adsorbs moisture through an osmotic pressure gradient (the water content of the cuticle increases by 35% in 30 minutes). At the same time, the acetylation substitution (≥ 85%) of acetylated hyaluronic acid enhances hydrophobicity, forming a breathable moisture retention film on the hair surface (the water loss rate ≤ 15% in 48 h). The combination of the two achieves a "dynamic water replenishment - long-term water locking" cycle to maintain a moist environment in the cortex.

[0059] (8)pH regulator (citric acid / lactic acid, ≤ 0.2%): Maintains the system pH at 5.0 - 5.8, matching the natural acidic environment of the scalp (pH 5.5), enhancing the cation adsorption efficiency, and preventing over-acidification from damaging hair keratin.

[0060] (9)Emulsifier (PEG-40 hydrogenated castor oil, 1 - 3%): Stabilizes the oil-water interface (interface tension ≤ 2 mN / m) through the polyethylene glycol chain (PEG-40) and the hydrophobic group of hydrogenated castor oil, preventing the aggregation of liposomes and conductive microflakes.

[0061] (10)Thickener (xanthan gum + magnesium aluminum silicate, 7 - 9%): Xanthan gum provides shear thinning properties (thixotropic index ≥ 4.0), reducing viscosity during application to ensure uniform coverage. Magnesium aluminum silicate: Layered silicate structure suspended particles (the sedimentation rate of conductive microflakes < 0.5%), maintaining the uniformity of the system.

[0062] (11)Lubricant (dimethyl silicone oil, 2 - 4%): The silicone oxygen chain with a low surface tension (21 mN / m) spreads on the hair surface, reducing the friction coefficient and minimizing combing damage.

[0063] (12)Preservative (phenoxyethanol + ethylhexylglycerin, 0.5 - 0.7%): Phenoxyethanol disrupts the cell membranes of microorganisms, and ethylhexylglycerin inhibits biofilm formation.

[0064] (13)Fragrance (β-cyclodextrin-embedded essential oil, 0.3 - 0.5%): The cavity of β-cyclodextrin embeds volatile essential oils (such as lavender), slowly releasing the fragrance (the fragrance retention rate ≥ 80% in 12 h) and reducing the risk of direct contact sensitization.

[0065] In some embodiments, the quaternization substitution degree of the quaternized sodium alginate ranges from 60% to 80%, and the molecular weight is 500,000 to 800,000 Da;

[0066] The polyquaternium is polyquaternium-67, and the cationic charge density is 0.8 to 1.2 meq / g;

[0067] The phosphorylation substitution degree of the phosphorylated wheat protein is ≥15%, and the molecular weight is 10 to 30 kDa;

[0068] The HLB value of polyethylene glycol-150 distearate is 8 to 10.

[0069] In some embodiments, the liposome particle size of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposome is 80 to 120 nm, the coating layer thickness is 8 to 15 nm, and the mass ratio of keratin peptide and tea tree oil encapsulated in the liposome is (1 to 3):1.

[0070] In some embodiments, the nanofiber diameter of the polyaniline nanofiber composite conductive microplate is 50 to 80 nm, the length is 1 to 3 μm, the conductivity is ≥20 S / cm, and the thickness of the polyethylene glycol-polylactic acid coating layer is 200 to 500 nm.

[0071] In some embodiments, the pH regulator is citric acid or lactic acid;

[0072] The emulsifier is PEG-40 hydrogenated castor oil;

[0073] The thickener is composed of xanthan gum and magnesium aluminum silicate, and the mass ratio of xanthan gum to magnesium aluminum silicate is 1:(1 to 3);

[0074] The lubricant is dimethyl silicone oil;

[0075] The preservative is composed of phenoxyethanol and ethylhexylglycerin, and the mass ratio of phenoxyethanol to ethylhexylglycerin is 1:(1 to 3);

[0076] The fragrance is natural plant essential oil encapsulated by β-cyclodextrin.

[0077] In summary, the hair conditioner provided by this application has a multi-dimensional synergistic action mechanism, which is specifically as follows:

[0078] (1) Charge gradient synergy: The charge gradient is designed as quaternized sodium alginate (+15 mV) → polyquaternium-67 (+5 mV) → phosphorylated wheat protein (-25 mV) to form a Zeta potential gradient. Thereby reducing the stiffness of hair caused by excessive cation adsorption, and at the same time constructing a "soft and moisturizing" composite network through electrostatic crosslinking.

[0079] (2)Intelligent release coordination: When blowing air or raising the ambient temperature to 40°C, the liposome releases keratin peptides to repair the cortex. Meanwhile, the scalp's weakly acidic environment (pH 5.5) releases tea tree oil to inhibit Malassezia (inhibition rate ≥ 99%). In addition, the conductive microchip drives the migration of charged components through microcurrent.

[0080] (3)Moisturizing-repair linkage: Glucosyl glycerol quickly penetrates to replenish water, and acetylated hyaluronic acid locks in water to form a film. Meanwhile, keratin peptides fill the defects of hair cuticles, and the cross-linking density of disulfide bonds is increased.

[0081] Figure 1 It is a schematic flow chart of the preparation method of the deeply nourishing hair conditioner provided by the embodiment of the present application.

[0082] In the second aspect, as Figure 1 shown, the present application provides a preparation method of the deeply nourishing hair conditioner described in any one of the embodiments in the first aspect, and the method includes:

[0083] S1. Obtain each raw material of the hair conditioner;

[0084] S2. Under stirring, add the quaternized sodium alginate, the glucosyl glycerol, the acetylated hyaluronic acid, the polyquaternium and the phosphorylated wheat protein into deionized water with a set temperature, and keep warm to obtain an aqueous phase mixture;

[0085] S3. Heat the polyethylene glycol-150 distearate, the emulsifier and the lubricant to the molten state to obtain an oil phase mixture;

[0086] S4. Perform high-speed homogenization treatment on the aqueous phase mixture and the oil phase mixture, and add a thickener to obtain a first emulsion mixture;

[0087] S5. Add the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposome and the polyaniline nanofiber composite conductive microchip to the first emulsion mixture to obtain a second emulsion mixture;

[0088] S6. Add the pH regulator, the preservative and the fragrance to the second emulsion mixture to obtain the hair conditioner.

[0089] In some embodiments, the pressure of the high-speed homogenization treatment is 5000-8000 psi, the number of cycles is 3-5 times, and the particle size of the emulsion after homogenization is ≤ 5 μm.

[0090] In some embodiments, the preparation method of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposome includes:

[0091] S1. Add linseed oil, lecithin, and cholesterol into chloroform, and then perform rotary evaporation to obtain a lipid film;

[0092] S2. Dissolve keratin peptide and tea tree oil in phosphate buffer solution to obtain a hydrated solution;

[0093] S3. Under a nitrogen atmosphere, add the hydrated solution to the lipid film, and then perform high-pressure homogenization to obtain liposomes;

[0094] S4. Under stirring, add the liposomes to the copolymer of N-isopropylacrylamide and acrylic acid to enable the copolymer to self-assemble on the surface of the liposomes, thereby obtaining the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid)-coated liposomes.

[0095] In some embodiments, the mass ratio of the linseed oil, the lecithin, and the cholesterol is 7:(1-3):1;

[0096] The mass concentration of the keratin peptide is 1-3%, and the mass concentration of the tea tree oil is 0.5-1.5%;

[0097] The molar ratio of the N-isopropylacrylamide and the acrylic acid is 85:15;

[0098] The mass ratio of the liposomes and the copolymer is 5:1.

[0099] The function of defining linseed oil:lecithin:cholesterol = 7:(1-3):1: Linseed oil can provide lipid fluidity and enhance the encapsulation rate of keratin peptide. Lecithin, as the main film-forming material, can regulate the film flexibility. Cholesterol can stabilize the lipid bilayer and reduce leakage.

[0100] The function of defining NIPAM:AA = 85:15: NIPAM can dominate the thermosensitivity, LCST≈40°C, ensuring the release triggered by the blowing temperature. AA can provide pH responsiveness, and the carboxyl group is protonated at pH 5.5, and the membrane permeability is increased by 3 times.

[0101] Defining liposomes:copolymer = 5:1, if the ratio is too low, incomplete coating will result, and if it is too high, copolymer aggregation will be caused.

[0102] In some embodiments, the preparation method of the polyaniline nanofiber composite conductive microplate includes:

[0103] Obtain polyaniline nanofiber powder;

[0104] Mix the polyaniline nanofiber powder, polyethylene glycol-polylactic acid, and dichloromethane to obtain a spinning solution; the mass concentration of the polyethylene glycol-polylactic acid in the spinning solution is 1-3%, and the mass ratio of the polyaniline nanofiber powder to the polyethylene glycol-polylactic acid is (1-3):1;

[0105] Perform electrospinning on the spinning solution and then perform a pulverization treatment to form a polyethylene glycol-polylactic acid coating layer with a set thickness on the surface of the polyaniline nanofibers, thereby obtaining the polyaniline nanofiber composite conductive micropieces; the voltage of the electrospinning is 18-20 kV, the propulsion rate is 0.7-0.9 mL / h, and the receiving distance is 10 cm.

[0106] Through precise control of various process parameters (temperature, pressure, ratio, etc.), this hair conditioner achieves a high degree of unity between the functional design of the ingredients and the synergistic optimization of the process. The interaction between the parameters (such as high-pressure homogenization to refine the emulsion and electrospinning to regulate conductivity) ensures the intelligent release and deep penetration of the active ingredients, breaking through the technical bottleneck of traditional hair conditioners.

[0107] In summary, the advantages of this application are mainly reflected in the following aspects:

[0108] (1) Multi-dimensional hair care effect: Through the charge gradient design, intelligent release mechanism, and the linkage of moisturizing and repair, a full-dimensional hair care effect from surface protection to deep repair is achieved, breaking through the single-effect limitation of traditional hair conditioners.

[0109] (2) Efficient ingredient synergy: Each chemical component acts synergistically at the molecular level. For example, quaternized sodium alginate and polyquaternium form a charge gradient, and phosphorylated wheat protein and cationic components are electrostatically crosslinked to jointly construct a "softening-moisturizing" composite network, significantly improving the hair care effect.

[0110] (3) Intelligent release technology: The temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes can intelligently release keratin peptides and tea tree oil under specific conditions (such as hair drying and scalp weak acidic environment), precisely matching the hair care scenario and improving the repair efficiency.

[0111] (4) Conductive enhanced penetration: The polyaniline nanofiber composite conductive micropieces use microcurrent to drive the migration of charged components, accelerate the release of liposomes, and further improve the repair effect.

[0112] (5) Advanced preparation process: Through advanced processes such as high-pressure homogenization to refine the emulsion and electrospinning to regulate conductivity, ensure the intelligent release and deep penetration of the active ingredients, and achieve a high degree of unity between the functional design of the ingredients and the synergistic optimization of the process.

[0113] (6) Safe and mild formula: Natural plant essential oils are selected as fragrances, and β-cyclodextrin embedding reduces the risk of sensitization. At the same time, mild preservatives are used to ensure the safety and mildness of the formula, which is suitable for various hair quality problems.

[0114] The following will further elaborate on this application in combination with specific embodiments. It should be understood that these embodiments are only used to illustrate this application and not to limit the scope of this application. The experimental methods without specific conditions noted in the following embodiments are generally determined according to industry standards. If there is no corresponding industry standard, they are carried out according to general international standards, conventional conditions, or the conditions recommended by the manufacturer.

[0115] Example 1: This example provides a deeply nourishing hair conditioner, which, by mass fraction, consists of the following chemical components:

[0116] Quaternized sodium alginate: 2% (degree of substitution 60%, molecular weight about 500,000 Da);

[0117] Polyquaternium-67: 1% (charge density 0.8 meq / g);

[0118] Phosphorylated wheat protein: 1% (degree of substitution 15%, molecular weight about 10 kDa);

[0119] Polyethylene glycol-150 distearate: 0.5% (HLB 8);

[0120] Temperature-controlled poly(NIPAM-co-AA) coated liposomes: 5% (particle size 80 nm, coating layer thickness 8 nm, keratin peptide: tea tree oil = 1:1);

[0121] Polyaniline nanofiber composite conductive microplates: 0.1% (diameter 50 nm, length 1 μm, conductivity 20 S / cm, coating layer 200 nm);

[0122] Glycerol glucoside: 1.5%, acetylated hyaluronic acid: 0.5%;

[0123] pH regulator (citric acid): 0.1%;

[0124] Emulsifier (PEG-40 hydrogenated castor oil): 1%;

[0125] Thickener (xanthan gum: magnesium aluminum silicate = 1:1): 7%;

[0126] Lubricant (dimethyl silicone oil): 2%;

[0127] Preservative (phenoxyethanol: ethylhexylglycerol = 1:1): 0.5%;

[0128] Fragrance (β-cyclodextrin embedded lavender essential oil): 0.3%;

[0129] Surplus: Deionized water.

[0130] Meanwhile, based on the above hair conditioner, this embodiment also provides a preparation method of the hair conditioner, and the method includes the following steps:

[0131] (1) Obtain each raw material of the hair conditioner;

[0132] (2) At a stirring speed of 400 rpm, add the quaternized sodium alginate, the glucosyl glycerol, the acetylated hyaluronic acid, the polyquaternium and the phosphorylated wheat protein into deionized water at 70 °C, and keep warm for 60 min to obtain an aqueous phase mixture;

[0133] Among them, the preparation method of the quaternized sodium alginate is: dissolve sodium alginate in deionized water (concentration 8%), add NaOH to adjust the pH to 11; dropwise add 3-chloro-2-hydroxypropyltrimethylammonium chloride (dissolved in an equal volume of water), control the temperature at 60 °C, the stirring speed is 300 rpm, and react for 6 h to obtain quaternized sodium alginate;

[0134] The preparation method of the phosphorylated wheat protein is: mix hydrolyzed wheat protein (Maclean Biochemical, molecular weight about 10 kDa, purity > 90%), sodium tripolyphosphate and deionized water, adjust the pH to 9.2, and stir at a constant temperature of 50 °C until the reduction amount of amino groups corresponds to a substitution degree of 15% to obtain phosphorylated wheat protein;

[0135] (3) Heat the polyethylene glycol-150 distearate, the emulsifier and the lubricant to 60 °C to obtain a molten oil phase mixture;

[0136] Among them, the preparation method of the polyethylene glycol-150 distearate is: feed according to PEG-150:stearic acid = 1:2.2 (molar ratio), add a catalyst (PTSA 1%); then raise the temperature to 150 °C, stir and react for 8 h under nitrogen protection, and remove the generated water through a water separator to obtain polyethylene glycol-150 distearate;

[0137] (4) Perform high-speed homogenization treatment on the aqueous phase mixture and the oil phase mixture, and add a thickener to obtain a first emulsion mixture;

[0138] Among them, the pressure of the high-speed homogenization treatment is 5000 psi, the number of cycles is 5 times, and the particle size of the emulsion after homogenization is ≤ 5 μm;

[0139] (5) Add the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposome and the polyaniline nanofiber composite conductive microplate to the first emulsion mixture to obtain a second emulsion mixture;

[0140] Among them, the preparation method of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes includes: dissolving 7 g of linseed oil, 1 g of lecithin, and 1 g of cholesterol in 50 mL of chloroform, and then subjecting it to ultrasonic treatment (40 kHz, 15 minutes) until completely dissolved, and transferring it to a rotary evaporator to obtain a lipid film; dissolving 1 g of keratin peptide (Jianchu Biotech, CAS: 69430-36-0) and 1 g of tea tree oil (tea tree essential oil from Jiangxi Wanlu Natural Flavors Co., Ltd., active substance content: 99%, CAS: 68647-73-4) in 100 mL of phosphate buffer solution, and magnetically stirring (500 rpm, 30 minutes) until uniform, and then subjecting it to ultrasonic treatment (40 kHz, 10 minutes) to ensure that the oil phase is dispersed into nanoemulsion droplets to obtain a hydration solution; adding the hydration solution to the flask containing the lipid film, controlling the temperature at 55 ± 1 °C under nitrogen protection, and magnetically stirring (300 rpm, 30 minutes) until uniform, and then performing high-pressure homogenization at a homogenization pressure of 15,000 psi and a circulation times of 3 times to obtain liposomes; dissolving N-isopropylacrylamide and acrylic acid with a molar ratio of 85:15 in deionized water (concentration 10% w / v), adding ammonium persulfate (APS, monomer:APS = 1:1.2, molar ratio), and under nitrogen protection, heating to 70 °C and stirring for 12 h to obtain a copolymer; under stirring (300 rpm), dispersing 5 g of the liposomes in a dichloromethane solution of 1 g of the copolymer (concentration 1 mg / mL), controlling the temperature at 45 ± 1 °C (higher than the LCST), magnetically stirring (100 rpm, 2 h), and centrifugally purifying (10,000 rpm, 20 minutes) to remove the unadsorbed copolymer, so that the copolymer self-assembles on the surface of the liposomes to obtain the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes;

[0141] The preparation method of the polyaniline nanofiber composite conductive microparticles includes: placing the reaction kettle in an ice-salt bath, controlling the system temperature at 0 - 5°C, adding 200 mL of deionized water and 1.5 g of DBSA, stirring until completely dissolved, then adding 2.5 g of aniline monomer, and magnetically stirring (500 rpm, 30 minutes) to form an aniline-DBSA complex. Dissolve 5.0 g of APS in pre-cooled water (0°C), slowly drop it into the reaction system (drop rate 1 mL / min), maintain the temperature at 0 - 5°C, react for 24 h, the solution changes from colorless to dark green, and then carry out purification to obtain polyaniline nanofiber powder; dissolve 1 g of polyaniline nanofiber powder and 1 g of polyethylene glycol-poly(lactic acid) (Pluronic® PE 6800) in 100 mL of dichloromethane, and magnetically stir (40°C, 2 h), and ultrasonically treat (40 kHz, 30 minutes) until uniformly dispersed to obtain a spinning solution; load the spinning solution into a syringe (needle diameter 0.6 mm), start the high-voltage power supply and the propulsion pump, continuously spin until the film thickness is 500 μm, collect the fiber membrane. The voltage of the electrospinning is 18 kV, the propulsion rate is 0.7 mL / h, the receiving distance is 10 cm, cut the fiber membrane into pieces and put them into a jet mill (pressure 0.8 MPa), grind for 10 minutes, and screen through 200 meshes (pore diameter 75 μm) to obtain the polyaniline nanofiber composite conductive microparticles;

[0142] (6) Add the pH regulator, the preservative, and the fragrance to the second emulsion mixture to obtain the hair conditioner;

[0143] The preparation method of the fragrance includes: dissolving β-cyclodextrin (purity ≥ 98%, substitution degree ≥ 6.0) in deionized water at 60°C, with a concentration of 12% (w / v); mixing lavender essential oil (model: Givaudan Lavender Oil LIS 3256) and β-cyclodextrin in a mass ratio of 1:2, controlling the temperature at 60 ± 2°C, magnetically stirring (500 rpm) for 4 hours, and then adjusting the pH to 2.5 - 3.5 with dilute hydrochloric acid to enhance the inclusion stability to obtain the fragrance.

[0144] Example 2: This example provides a deeply nourishing hair conditioner. By mass fraction, the hair conditioner is composed of the following chemical components:

[0145] Quaternized sodium alginate: 3% (substitution degree 70%, molecular weight about 650,000 Da);

[0146] Polyquaternium-67: 2% (charge density 1.0 meq / g);

[0147] Phosphorylated wheat protein: 2% (substitution degree 20%, molecular weight about 20 kDa);

[0148] Polyethylene glycol-150 distearate: 1.2% (HLB 9);

[0149] Thermoresponsive poly(NIPAM-co-AA)-coated liposomes: 5.5% (particle size 100 nm, coating layer thickness 12 nm, keratin peptide: tea tree oil = 2:1);

[0150] Polyaniline nanofiber composite conductive microflakes: 0.2% (diameter 65 nm, length 2 μm, conductivity 25 S / cm, coating layer 350 nm);

[0151] Glucosylglycerol: 2.0%, acetylated hyaluronic acid: 1.0%;

[0152] pH regulator (lactic acid): 0.15%;

[0153] Emulsifier (PEG-40 hydrogenated castor oil): 2%;

[0154] Thickener (xanthan gum: magnesium aluminum silicate = 1:2): 8%;

[0155] Lubricant (dimethyl silicone oil): 3%;

[0156] Preservative (phenoxyethanol: ethylhexylglycerin = 1:2): 0.6%;

[0157] Fragrance (β-cyclodextrin-encapsulated lavender essential oil): 0.4%;

[0158] Balance: deionized water.

[0159] Meanwhile, based on the above hair conditioner, this example also provides a preparation method of the hair conditioner, and the method includes the following steps:

[0160] (1) Obtain each raw material of the hair conditioner;

[0161] (2) Under a stirring speed of 400 rpm, add the quaternized sodium alginate, the glucosylglycerol, the acetylated hyaluronic acid, the polyquaternium and the phosphorylated wheat protein into deionized water at 70 °C, and keep warm for 60 min to obtain an aqueous phase mixture;

[0162] Among them, the preparation method of the quaternized sodium alginate is: dissolve sodium alginate in deionized water (concentration 8%), add NaOH to adjust the pH to 11; dropwise add 3-chloro-2-hydroxypropyltrimethylammonium chloride (dissolved in an equal volume of water), control the temperature at 60 °C, the stirring speed at 300 rpm, and react for 6 h to obtain quaternized sodium alginate;

[0163] The preparation method of the phosphorylated wheat protein is as follows: Hydrolyzed wheat protein (Aladdin reagent, molecular weight about 20 kDa, purity > 90%) is mixed with sodium tripolyphosphate and deionized water, the pH is adjusted to 9.2, and the mixture is stirred at a constant temperature of 50 °C until the degree of substitution corresponding to the reduced amount of amino groups reaches 20%, obtaining phosphorylated wheat protein;

[0164] (3) Heat the polyethylene glycol-150 distearate, the emulsifier and the lubricant to 60 °C to obtain a molten oil-phase mixture;

[0165] Among them, the preparation method of the polyethylene glycol-150 distearate is as follows: Charge according to the molar ratio of PEG-150: stearic acid = 1: 2.2, and add a catalyst (1% PTSA); then raise the temperature to 150 °C, stir and react for 8 h under nitrogen protection, and remove the generated water through a water separator to obtain polyethylene glycol-150 distearate.

[0166] (4) Perform high-speed homogenization treatment on the aqueous-phase mixture and the oil-phase mixture, and add a thickening agent to obtain a first emulsion mixture;

[0167] Among them, the pressure of the high-speed homogenization treatment is 6000 psi, the number of cycles is 4 times, and the particle size of the emulsion after homogenization is ≤ 5 μm;

[0168] (5) Add the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid)-coated liposomes and the polyaniline nanofiber composite conductive microsheets to the first emulsion mixture to obtain a second emulsion mixture;

[0169] Among them, the preparation method of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes includes: dissolving 7 g of linseed oil, 2 g of lecithin, and 1 g of cholesterol in 50 mL of chloroform, and then subjecting it to ultrasonic treatment (40 kHz, 15 minutes) until completely dissolved, and transferring it to a rotary evaporator to obtain a lipid film; dissolving 2 g of keratin peptide and 1 g of tea tree oil in 100 mL of phosphate buffer solution, and magnetically stirring (500 rpm, 30 minutes) until uniform, and then subjecting it to ultrasonic treatment (40 kHz, 10 minutes) to ensure that the oil phase is dispersed into nanoemulsion droplets to obtain a hydration solution; adding the hydration solution to the flask containing the lipid film, controlling the temperature at 55±1°C under nitrogen protection, and magnetically stirring (300 rpm, 30 minutes) until uniform, and then performing high-pressure homogenization at a homogenization pressure of 15,000 psi and the number of cycles: 3 times to obtain liposomes; dissolving N-isopropylacrylamide and acrylic acid with a molar ratio of 85:15 in deionized water (concentration 10% w / v), adding ammonium persulfate (APS, monomer:APS = 1:1.2, molar ratio), and heating to 70°C under nitrogen protection and stirring for 12 h to obtain a copolymer; dispersing 5 g of the liposomes in a dichloromethane solution of 1 g of the copolymer (concentration 1 mg / mL) under stirring (300 rpm), controlling the temperature at 45±1°C (higher than the LCST), magnetically stirring (100 rpm, 2 h), and centrifuging and purifying (10,000 rpm, 20 minutes) to remove the unadsorbed copolymer so that the copolymer self-assembles on the surface of the liposomes to obtain the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes;

[0170] The preparation method of the polyaniline nanofiber composite conductive microflakes includes: placing the reaction kettle in an ice-salt bath, controlling the system temperature at 0 - 5°C, adding 200 mL of deionized water and 1.5 g of DBSA, stirring until completely dissolved, then adding 2.5 g of aniline monomer, and magnetically stirring (500 rpm, 30 minutes) to form an aniline-DBSA complex. Dissolve 5.0 g of APS in pre-cooled water (0°C), slowly add it dropwise to the reaction system (dropwise addition rate 1 mL / min), maintain the temperature at 0 - 5°C, react for 24 h, and the solution changes from colorless to dark green. Then, carry out purification to obtain polyaniline nanofiber powder; dissolve 4 g of polyaniline nanofiber powder and 2 g of polyethylene glycol-polylactic acid in 100 mL of dichloromethane, and magnetically stir (40°C, 2 h), and perform ultrasonic treatment (40 kHz, 30 minutes) until uniformly dispersed to obtain a spinning solution; load the spinning solution into a syringe (needle diameter 0.6 mm), start the high-voltage power supply and the propulsion pump, continuously spin until the film thickness reaches 500 μm, collect the fiber membrane. The voltage of the electrospinning is 19 kV, the propulsion rate is 0.8 mL / h, and the receiving distance is 10 cm. Cut the fiber membrane into pieces and put them into a jet mill (pressure 0.8 MPa), pulverize for 10 minutes, and screen through 200 meshes (pore diameter 75 μm) to obtain the polyaniline nanofiber composite conductive microflakes;

[0171] (6) Add the pH regulator, the preservative, and the fragrance to the second emulsion mixture to obtain the hair conditioner;

[0172] The preparation method of the fragrance includes: dissolving β-cyclodextrin (purity ≥ 98%, substitution degree ≥ 6.0) in deionized water at 60°C, with a concentration of 12% (w / v); mixing lavender essential oil (model: Givaudan Lavender Oil LIS 3256) and β-cyclodextrin in a mass ratio of 1:2, controlling the temperature at 60 ± 2°C, magnetically stirring (500 rpm) for 4 hours, and then adjusting the pH to 2.5 - 3.5 with dilute hydrochloric acid to enhance the inclusion stability to obtain the fragrance.

[0173] Example 3: This example provides a deeply nourishing hair conditioner. By mass fraction, the hair conditioner is composed of the following chemical components:

[0174] Quaternized sodium alginate: 4% (substitution degree 80%, molecular weight about 800,000 Da);

[0175] Polyquaternium-67: 3% (charge density 1.2 meq / g);

[0176] Phosphorylated wheat protein: 3% (substitution degree 25%, molecular weight about 20 kDa);

[0177] Polyethylene glycol-150 distearate: 2% (HLB 10);

[0178] Thermoresponsive poly(NIPAM-co-AA) coated liposomes: 6% (particle size 120 nm, coating layer thickness 15 nm, keratin peptide:tea tree oil = 3:1);

[0179] Polyaniline nanofiber composite conductive microplates: 0.3% (diameter 80 nm, length 3 μm, conductivity 30 S / cm, coating layer 500 nm);

[0180] Glycerol glucoside: 2.5%, acetylated hyaluronic acid: 1.5%;

[0181] pH regulator (lactic acid): 0.2%;

[0182] Emulsifier (PEG-40 hydrogenated castor oil): 3%;

[0183] Thickener (xanthan gum:aluminum magnesium silicate = 1:3): 9%;

[0184] Lubricant (dimethyl silicone oil): 4%;

[0185] Preservative (phenoxyethanol:ethylhexylglycerin = 1:3): 0.7%;

[0186] Fragrance (β-cyclodextrin encapsulated lavender essential oil): 0.5%;

[0187] Balance: deionized water.

[0188] Meanwhile, based on the above hair conditioner, this embodiment also provides a preparation method of the hair conditioner, and the method includes the following steps:

[0189] (1) Obtain each raw material of the hair conditioner;

[0190] (2) At a stirring speed of 400 rpm, add the quaternized sodium alginate, the glycerol glucoside, the acetylated hyaluronic acid, the polyquaternium and the phosphorylated wheat protein into deionized water at 70 °C, and keep warm for 60 min to obtain an aqueous phase mixture;

[0191] Among them, the preparation method of the quaternized sodium alginate is: dissolve sodium alginate in deionized water (concentration 8%), add NaOH to adjust the pH to 11; dropwise add 3-chloro-2-hydroxypropyltrimethylammonium chloride (dissolved in equal volume of water), control the temperature at 60 °C, stir at a speed of 300 rpm, and react for 6 h to obtain quaternized sodium alginate;

[0192] The preparation method of the phosphorylated wheat protein is as follows: Hydrolyzed wheat protein (Aladdin reagent, molecular weight about 20 kDa, purity > 90%) is mixed with sodium tripolyphosphate and deionized water, the pH is adjusted to 9.2, and it is stirred at a constant temperature of 50 °C until the reduction amount of amino groups corresponds to a substitution degree of 35% to obtain phosphorylated wheat protein;

[0193] (3) Heat the polyethylene glycol-150 distearate, the emulsifier and the lubricant to 60 °C to obtain a molten oil-phase mixture;

[0194] Among them, the preparation method of the polyethylene glycol-150 distearate is as follows: Charge according to PEG-150: stearic acid = 1: 2.2 (molar ratio), and add a catalyst (PTSA 1%); then raise the temperature to 150 °C, stir and react for 8 h under nitrogen protection, and remove the generated water through a water separator to obtain polyethylene glycol-150 distearate.

[0195] (4) Perform high-speed homogenization treatment on the aqueous-phase mixture and the oil-phase mixture, and add a thickener to obtain a first emulsion mixture;

[0196] Among them, the pressure of the high-speed homogenization treatment is 8000 psi, the number of cycles is 3 times, and the particle size of the emulsion after homogenization is ≤ 5 μm;

[0197] (5) Add the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes and the polyaniline nanofiber composite conductive micro-sheets to the first emulsion mixture to obtain a second emulsion mixture;

[0198] Among them, the preparation method of the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes includes: dissolving 7 g of linseed oil, 3 g of lecithin, and 1 g of cholesterol in 50 mL of chloroform, and then subjecting to ultrasonic treatment (40 kHz, 15 minutes) until completely dissolved, and transferring to a rotary evaporator to obtain a lipid film; dissolving 3 g of keratin peptides and 1 g of tea tree oil in 100 mL of phosphate buffer solution, and magnetically stirring (500 rpm, 30 minutes) until uniform, and then subjecting to ultrasonic treatment (40 kHz, 10 minutes) to ensure that the oil phase is dispersed into nanoemulsion droplets to obtain a hydration solution; adding the hydration solution to the flask containing the lipid film, controlling the temperature at 55±1°C under nitrogen protection, and magnetically stirring (300 rpm, 30 minutes) until uniform, and then performing high-pressure homogenization at a homogenization pressure of 15,000 psi and the number of cycles: 3 times to obtain liposomes; dissolving N-isopropylacrylamide and acrylic acid with a molar ratio of 85:15 in deionized water (concentration 10% w / v), adding ammonium persulfate (APS, monomer:APS = 1:1.2, molar ratio), and heating to 70°C under nitrogen protection and stirring for reaction for 12 h to obtain a copolymer; dispersing 5 g of the liposomes in a dichloromethane solution of 1 g of the copolymer (concentration 1 mg / mL) under stirring (300 rpm), controlling the temperature at 45±1°C (higher than the LCST), magnetically stirring (100 rpm, 2 h), and centrifugally purifying (10,000 rpm, 20 minutes) to remove the unadsorbed copolymer so that the copolymer self-assembles on the surface of the liposomes to obtain the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid) coated liposomes;

[0199] The preparation method of the polyaniline nanofiber composite conductive microflakes includes: placing the reaction kettle in an ice-salt bath, controlling the system temperature at 0 - 5°C, adding 200 mL of deionized water and 1.5 g of DBSA, stirring until completely dissolved, then adding 2.5 g of aniline monomer, and magnetically stirring (500 rpm, 30 minutes) to form an aniline-DBSA complex. Dissolve 5.0 g of APS in pre-cooled water (0°C), slowly dropwise add it to the reaction system (dropwise addition rate 1 mL / min), maintain the temperature at 0 - 5°C, react for 24 h, and the solution changes from colorless to dark green. Then, perform purification to obtain polyaniline nanofiber powder; dissolve 5 g of polyaniline nanofiber powder and 3 g of polyethylene glycol-polylactic acid in 100 mL of dichloromethane, and magnetically stir (40°C, 2 h), and perform ultrasonic treatment (40 kHz, 30 minutes) until evenly dispersed to obtain a spinning solution; load the spinning solution into a syringe (needle diameter 0.6 mm), start the high-voltage power supply and the propulsion pump, continuously spin until the film thickness reaches 500 μm, collect the fiber membrane. The voltage of the electrospinning is 20 kV, the propulsion rate is 0.9 mL / h, and the receiving distance is 10 cm. Cut the fiber membrane into pieces and put them into a jet mill (pressure 0.8 MPa), grind for 10 minutes, and screen through a 200-mesh sieve (pore diameter 75 μm) to obtain the polyaniline nanofiber composite conductive microflakes;

[0200] (6) Add the pH regulator, the preservative, and the fragrance agent to the second emulsion mixture to obtain the hair conditioner;

[0201] The preparation method of the fragrance agent includes: dissolving β-cyclodextrin (purity ≥ 98%, substitution degree ≥ 6.0) in deionized water at 60°C, with a concentration of 12% (w / v); mixing lavender essential oil (model: Givaudan Lavender Oil LIS 3256) and β-cyclodextrin in a mass ratio of 1:2, controlling the temperature at 60 ± 2°C, magnetically stirring (500 rpm) for 4 hours, and then adjusting the pH to 2.5 - 3.5 with dilute hydrochloric acid to enhance the inclusion stability to obtain the fragrance agent.

[0202] Comparative Example 1: Based on what was disclosed in Example 2, the following modifications were made in this comparative example:

[0203] Quaternized sodium alginate is not added to the hair conditioner.

[0204] Comparative Example 2: Based on what was disclosed in Example 2, the following modifications were made in this comparative example:

[0205] Polyquaternium is not added to the hair conditioner.

[0206] Comparative Example 3: Based on what was disclosed in Example 2, the following modifications were made in this comparative example:

[0207] Phosphorylated wheat protein is not added to the hair conditioner.

[0208] Comparative Example 4: On the basis of the disclosure of Example 2, the following modifications are made:

[0209] Polyethylene glycol-150 distearate is not added to the hair conditioner.

[0210] Comparative Example 5: On the basis of the disclosure of Example 2, the following modifications are made:

[0211] Thermoresponsive poly(N-isopropylacrylamide-co-acrylic acid)-coated liposomes are not added to the hair conditioner, and keratin peptides and tea tree oil are added alone.

[0212] Comparative Example 6: On the basis of the disclosure of Example 2, the following modifications are made:

[0213] Polyaniline nanofiber composite conductive microplates are not added to the hair conditioner.

[0214] Comparative Example 7: On the basis of the disclosure of Example 2, the following modifications are made:

[0215] Gluconolactone and acetylated hyaluronic acid are not added to the hair conditioner.

[0216] The hair conditioners obtained from Examples 1 to 3 and Comparative Examples 1 to 7 were subjected to performance measurements, and the measurement results are shown in Table 1. The measurement methods are as follows:

[0217] Coefficient of friction (100 combs): TRIBOgear friction tester (ASTM D1894), load 50 g, speed 10 cm / s, measure 10 times and take the average.

[0218] Water retention rate after 48 hours: Weigh the hair strands after applying the hair conditioner, place them in an environment of 30°C / 50%RH, and calculate the water loss rate.

[0219] Penetration depth of keratin peptides: Confocal Raman imaging (excitation wavelength 785 nm), labeled with a keratin peptide fluorescent probe (FITC).

[0220] Antibacterial rate of tea tree oil: Quantify the number of Malassezia furfur by qPCR and compare the number of colonies before and after treatment.

[0221] Dual-trigger release efficiency: Franz diffusion cell (40°C / pH 5.5), HPLC is used to measure the release amounts of keratin peptides and tea tree oil.

[0222] Conductive penetration depth: After electroosmotic driving, confocal Raman imaging is used to measure the distribution depth of keratin peptides.

[0223] Electrical conductivity: Four-probe method (Keithley 2400), surface conductivity was measured after applying conditioner to hair.

[0224] Aroma retention rate (12h): headspace GC-MS analysis of the percentage of free aroma.

[0225] Storage stability (6 months): Dynamic light scattering (DLS) was used to measure the change in particle size, and HPLC was used to detect the retention of active ingredients.

[0226] Table 1 Performance of the hair conditioners of Examples 1 to 3 and Comparative Examples 1 to 7

[0227]

[0228] From Table 1, we can see that:

[0229] Comparative Example 1 (without quaternized sodium alginate):

[0230] The friction coefficient increases (0.75): the lack of a cationic film layer cannot neutralize the static electricity on the hair, causing the hair scales to curl up more severely.

[0231] The water retention rate and penetration depth decrease: the charge gradient is destroyed, phosphorylated wheat protein cannot form a water-locking network, and the penetration of active ingredients is hindered.

[0232] Comparative Example 2 (without polyquaternium-67):

[0233] Reduced flexibility (friction coefficient 0.68): incomplete charge gradient and uneven cation deposition lead to stiff hair.

[0234] The antibacterial rate decreased (88%): the release efficiency of tea tree oil decreased, and the loss of charge gradient weakened the regulation of scalp microenvironment.

[0235] Comparative Example 3 (non-phosphorylated wheat protein):

[0236] The water retention rate drops sharply (59%): the three-dimensional water-locking network is lost and water is lost quickly.

[0237] The conductivity decreases (14 S / cm): the anion-cation electrostatic crosslinking is interrupted and the conductive network is incomplete.

[0238] Comparative Example 4 (without polyethylene glycol-150 distearate):

[0239] Poor emulsion stability (particle size change 5%): the charge shielding effect disappears, and the liposomes and conductive microsheets aggregate and settle.

[0240] Reduced release efficiency (keratin peptide 70%): The instability of the emulsification system leads to a decrease in the liposome encapsulation rate.

[0241] Comparative Example 5 (without temperature-controlled liposomes):

[0242] Dual-trigger release failure (51% keratin peptide, 54% tea tree oil): The active ingredients rely only on passive diffusion, resulting in low efficiency.

[0243] Decrease in antibacterial rate (65%): The tea tree oil cannot be released in a targeted manner, significantly reducing the antibacterial effect.

[0244] Comparative Example 6 (without conductive microchips):

[0245] Insufficient penetration depth (233 μm): Lack of electroosmotic drive, and the keratin peptide penetrates only by diffusion.

[0246] Extremely low conductivity (10 S / cm): The conductive network is missing, and it cannot cooperate with liposomes for release.

[0247] Comparative Example 7 (without glyceroglucoside + acetylated hyaluronic acid):

[0248] Decrease in water retention rate and aroma retention rate (58%, 50%): The dynamic moisturizing network is damaged, and moisture and aroma are lost quickly.

[0249] Fluctuation in repair depth (780 μm): Only relying on conductive penetration, lacking the support of a moist environment for repair efficiency.

[0250] It can be seen from this that Examples 1 to 3, through the linkage design of charge gradient coordination, intelligent dual-trigger release, conductive drive penetration, and dynamic moisturizing network, are significantly superior to all comparative examples in terms of core indicators such as flexibility, water retention rate, and repair depth. Each comparative example shows a significant decrease in performance due to the absence of a single component, verifying the necessity and synergistic effect of each component in the formula of the present invention.

[0251] In order to explore the safety of the hair conditioner, the hair conditioner obtained in Example 2 was subjected to a skin irritation test. The test method is as follows:

[0252] Patch test: Apply the hair conditioner to the back skin (0.02 g / cm²), seal and apply for 48 hours, and observe reactions such as erythema and edema. Continuously use it for 28 days, and evaluate the irritation symptoms daily (score according to the ICDRG standard).

[0253] Finally, the statistical result shows that the irritation index ≤ 0.3 (no irritation), meeting the ISO 10993-10 standard.

[0254] The various embodiments of the present application may exist in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity and should not be construed as a rigid limitation on the scope of the present application; therefore, it should be considered that the range description has specifically disclosed all possible sub-ranges and the individual values within that range. For example, it should be considered that the range description from 1 to 6 has specifically disclosed sub-ranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., and the individual numbers within that range, such as 1, 2, 3, 4, 5, and 6, and this applies regardless of the range. Additionally, whenever a numerical range is indicated herein, it means including any recited number (fractional or integer) within the indicated range.

[0255] In addition, in the description of the specification of the present application, the terms "including", "comprising", etc. mean "including but not limited to". In this document, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. In this document, "and / or" describes the associated relationship of associated objects and indicates that three relationships may exist. For example, A and / or B may represent: the case where A exists alone, the case where A and B exist simultaneously, and the case where B exists alone. Wherein A and B may be singular or plural.

[0256] The above are only specific embodiments of the present application, enabling those skilled in the art to understand or implement the present application. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to these embodiments shown herein, but rather to the broadest scope consistent with the principles and novel features claimed herein.

Claims

1. A deep nourishing conditioner, characterized in that: The hair conditioner is composed of the following chemical components by mass fraction: quaternized sodium alginate: 2-4%, polyquaternium salt: 1-3%, phosphorylated wheat protein: 1-3%, polyethylene glycol-150 distearate: 0.5-2%, temperature-controlled poly (N-isopropylacrylamide-co-acrylic acid) coated liposomes: 5-6%, polyaniline nanofiber composite conductive microsheets: 0.1-0.3%, glycerol glucoside: 1.5-2.5%, acetylated hyaluronic acid: 0.5-1.5%, pH regulator ≤ 0.2%, emulsifier: 1-3%, thickener: 7-9%, lubricant: 2-4%, preservative: 0.5-0.7%, fragrance 0.3-0.5%, and the balance is deionized water; wherein, The polyquaternium salt is polyquaternium-67; The temperature-controlled poly (N-isopropylacrylamide-co-acrylic acid)-coated liposomes contain keratin peptides and tea tree oil in the liposomes; The preparation method of the temperature-controlled poly (N-isopropylacrylamide-co-acrylic acid) coated liposomes comprises: Linseed oil, lecithin and cholesterol were added to chloroform and then rotary evaporated to obtain lipid film; Dissolving keratin peptide and tea tree oil in phosphate buffer to obtain a hydrated solution; Under a nitrogen atmosphere, the hydration solution is added to the lipid membrane, followed by high-pressure homogenization to obtain liposomes; Under stirring, adding the liposome to a copolymer solution of N-isopropylacrylamide and acrylic acid, so that the copolymer self-assembles on the surface of the liposome to obtain the temperature-controlled poly (N-isopropylacrylamide-co-acrylic acid) coated liposome; The polyaniline nanofiber composite conductive microsheet contains a polyethylene glycol-polylactic acid coating layer; The preparation method of the polyaniline nanofiber composite conductive microsheet comprises: The polyaniline nanofiber powder, polyethylene glycol-polylactic acid and dichloromethane are mixed to obtain a spinning solution; the mass concentration of the polyethylene glycol-polylactic acid in the spinning solution is 1-3%, and the mass ratio of the polyaniline nanofiber powder to the polyethylene glycol-polylactic acid is (1-3):1; The spinning solution is subjected to electrospinning and then pulverized to form a polyethylene glycol-polylactic acid coating layer with a set thickness on the surface of the polyaniline nanofiber to obtain the polyaniline nanofiber composite conductive microsheet; the voltage of the electrospinning is 18 to 20 kV, the propulsion rate is 0.7 to 0.9 mL / h, and the receiving distance is 10 cm.

2. The deep nourishing conditioner according to claim 1, characterized in that The quaternary ammonium substitution degree of the quaternary ammonium sodium alginate is in the range of 60% to 80%, and the molecular weight is in the range of 500,000 to 800,000 Da; The cationic charge density of the polyquaternary ammonium salt is 0.8 to 1.2 meq / g; The phosphorylated wheat protein has a phosphorylation substitution degree of ≥15% and a molecular weight of 10 to 30 kDa; The HLB value of the polyethylene glycol-150 distearate is 8-10.

3. The deep nourishing conditioner according to claim 1, characterized in that The liposome particle size of the temperature-controlled poly (N-isopropylacrylamide-co-acrylic acid) coated liposome is 80-120 nm, the coating layer thickness is 8-15 nm, and the mass ratio of keratin peptide and tea tree oil encapsulated in the liposome is (1-3):

1.

4. The deep nourishing conditioner according to claim 1, characterized in that The nanofiber diameter of the polyaniline nanofiber composite conductive microsheet is 50-80nm, the length is 1-3μm, the conductivity is ≥20S / cm, and the thickness of the polyethylene glycol-polylactic acid coating layer is 200-500nm.

5. The deep nourishing conditioner according to claim 1, characterized in that: The pH regulator is citric acid or lactic acid; The emulsifier is PEG-40 hydrogenated castor oil; The thickener is composed of xanthan gum and magnesium aluminum silicate, and the mass ratio of the xanthan gum to the magnesium aluminum silicate is 1:(1-3); The lubricant is dimethyl silicone oil; The preservative consists of phenoxyethanol and ethylhexylglycerin, and the mass ratio of the phenoxyethanol to the ethylhexylglycerin is 1:(1-3); The aromatic agent is natural plant essential oil embedded in beta-cyclodextrin.

6. A method for preparing the deep nourishing hair conditioner according to any one of claims 1 to 5, characterized in that: The method comprises: Obtaining the raw materials of the hair conditioner; Under stirring, adding the quaternized sodium alginate, the glycerol glucoside, the acetylated hyaluronic acid, the polyquaternium salt and the phosphorylated wheat protein into deionized water at a set temperature, and keeping the temperature to obtain an aqueous phase mixture; heating the polyethylene glycol-150 distearate, the emulsifier and the lubricant to a molten state to obtain an oil phase mixed liquid; The aqueous phase mixed liquid and the oil phase mixed liquid are subjected to high-speed homogenization treatment, and a thickener is added to obtain a first emulsion mixed liquid; Adding the temperature-controlled poly(N-isopropylacrylamide-co-acrylic acid)-coated liposomes and the polyaniline nanofiber composite conductive microsheet to the first emulsion mixture to obtain a second emulsion mixture; The pH regulator, the preservative and the fragrance are added to the second emulsion mixture to obtain the hair conditioner.

7. The method for preparing the deep nourishing hair conditioner according to claim 6, characterized in that: The high-speed homogenization treatment has a pressure of 5000-8000 psi, a cycle number of 3-5 times, and an emulsion particle size of ≤5 μm after homogenization.

8. The method for preparing the deep nourishing hair conditioner according to claim 6, characterized in that: The preparation method of the temperature-controlled poly (N-isopropylacrylamide-co-acrylic acid) coated liposomes comprises: Linseed oil, lecithin and cholesterol were added to chloroform and then rotary evaporated to obtain lipid film; Dissolving keratin peptide and tea tree oil in phosphate buffer to obtain a hydrated solution; Under a nitrogen atmosphere, the hydration solution is added to the lipid membrane, followed by high-pressure homogenization to obtain liposomes; Under stirring, the liposome is added to a copolymer solution of N-isopropylacrylamide and acrylic acid, so that the copolymer is self-assembled on the surface of the liposome to obtain the temperature-controlled poly (N-isopropylacrylamide-co-acrylic acid) coated liposome.

9. The method for preparing the deep nourishing hair conditioner according to claim 8, characterized in that: The mass ratio of the flaxseed oil, the lecithin and the cholesterol is 7:(1-3):1; The mass concentration of the keratin peptide is 1-3%, and the mass concentration of the tea tree oil is 0.5-1.5%; The molar ratio of the N-isopropylacrylamide to the acrylic acid is 85:15; The mass ratio of the liposome to the copolymer after high pressure homogenization is 5:1.

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