Mouse tail intravenous injection device

Abstract

The invention discloses a mouse tail intravenous injection device, which relates to the technical field of test instruments, and comprises a fixing part capable of accommodating a mouse and fixing the tail of the mouse; the positioning part is arranged above the fixing part and can identify the vein position of the tail part of the mouse; the injection part is arranged at one end of the fixing part and can drive an injection needle to inject liquid medicine into the vein of the tail of the mouse according to the recognized vein position of the tail of the mouse. The rat caudal vein injection device provided by the invention can be used for accurately positioning and injecting rat caudal veins.

Description

Technical Field

[0001] The invention relates to the technical field of experimental instruments, in particular to a rat tail vein injection device. Background Art

[0002] Tail vein injection is one of the main ways to administer drugs to experimental mice. When giving tail vein injection to mice in the laboratory, the operator fixes the mouse's body to expose the mouse's tail, and then injects the tail vein of the mouse. Since the mouse's tail is thin, it is not easy to locate and inject the tail vein when using manual injection. Therefore, it is urgent to design a technical solution that can accurately locate and inject the mouse's tail vein. Summary of the invention

[0003] The object of the present invention is to provide a rat tail vein injection device to solve the problems existing in the above-mentioned prior art and to enable accurate positioning and injection of the rat tail vein.

[0004] To achieve the above object, the present invention provides the following solutions:

[0005] The present invention provides a rat tail vein injection device, comprising:

[0006] A fixing part, which can accommodate a mouse and fix the tail of the mouse;

[0007] A positioning part, disposed above the fixing part, capable of identifying the position of the vein of the mouse tail;

[0008] The injection part is arranged at one end of the fixing part, and can drive the injection of intravenous injection liquid to the mouse tail according to the identified position of the mouse tail vein.

[0009] Preferably, the fixing part comprises a mouse cage and a mouse tail clamp, wherein the mouse cage is used to accommodate and fix the mouse, and the mouse tail clamp is provided at one end of the mouse cage, and the mouse tail clamp can fix and clamp the tail of the mouse.

[0010] Preferably, the mouse tail clamp comprises two symmetrically arranged magnet blocks, the end of the magnet block away from the mouse cage is a smooth wedge-shaped structure, and the two magnet blocks can fix and clamp the mouse tail.

[0011] Preferably, the positioning part includes a positioning bracket, on which is provided a vascular imager, which can illuminate the mouse's tail to identify the location of the vein and transmit the data to a control end, and the control end can control the injection part to inject the drug solution into the mouse's tail intravenously according to the data transmitted by the vascular imager.

[0012] Preferably, the injection part includes a first feeding device and a second feeding device, an injection needle is fixed on the top of the first feeding device, and the second feeding device is fixed on the end of the first feeding device, the first feeding device can drive the injection needle and the second feeding device to move axially and horizontally; the second feeding device can drive the piston rod of the injection needle to move axially.

[0013] Preferably, it further comprises a base, and the fixing part, the positioning part and the injection part are all arranged on the base; and a plurality of legs are threadedly connected to the bottom of the base.

[0014] Preferably, the first feeding device includes a first guide rail, two first guide rods are provided in the first guide rail, a first slider is slidably provided on the first guide rod, a first lead screw is provided between the two first guide rods, a lead screw nut on the first lead screw is fixedly connected to the first slider, and one end of the first lead screw is transmission-connected to a first stepper motor; a mounting plate is fixedly provided on the top of the first slider, a clamping groove is provided at one end of the mounting plate, and the clamping groove is used to fix and clamp the injection needle, and the second feeding device is provided at the other end of the mounting plate.

[0015] Preferably, the second feeding device comprises a linear motor, and a push block is fixedly provided at the end of the output shaft of the linear motor, and the push block can abut against the end of the piston rod of the injection needle.

[0016] Preferably, the positioning bracket is provided with a vertical slide rail, a vertical slide is slidably provided on the vertical slide rail, the vascular imager is fixed on the vertical slide, the vertical slide is connected with a vertical driving device, and the vertical driving device can drive the vertical slide to move up and down.

[0017] Preferably, the fixed part also includes a fixed bracket, two second guide rods are provided on the fixed bracket, a second slider is slidably provided on the second guide rods, a second lead screw is provided between the two second guide rods, a lead screw nut on the second lead screw is fixedly connected to the second slider, and one end of the second lead screw is transmission-connected to a second stepping motor; the squirrel cage and the rat tail clamp are fixedly provided on the top of the second slider; the second guide rod is arranged perpendicular to the axis of the injection part.

[0018] Compared with the prior art, the present invention has achieved the following technical effects:

[0019] The present invention adopts a fixing part, which can accommodate and fix the mouse to prevent it from moving around, and can also fix its tail, so as to facilitate exposing the position to be injected; the positioning part is arranged on one side of the upper part of the fixing part, and can realize the vein position of the mouse tail, and the injection part can drive the injection target to inject the drug solution at the vein position according to the recognized vein position information; thus, the present invention can accurately locate the vein position and inject the drug solution at the position. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 It is a schematic diagram of the structure of a rat tail vein injection device in one or some embodiments of the present invention;

[0022] Figure 2 It is a schematic diagram of the structure of the other side of the rat tail vein injection device in one or some embodiments of the present invention;

[0023] Figure 3 It is a schematic diagram of the partial structure of a rat tail vein injection device in one or some embodiments of the present invention;

[0024] Figure 4 Schematic diagram of the rat tail clamp of the rat tail vein injection device in one or some embodiments of the present invention.

[0025] In the figure: 1-base, 2-rat cage, 3-rat tail clamp, 4-positioning bracket, 5-vascular imager, 6-injection needle, 7-first guide rail, 8-first guide rod, 9-first lead screw, 10-first stepper motor, 11-first slider, 12-mounting plate, 13-linear motor, 14-push block, 15-fixed bracket, 16-second guide rod, 17-second lead screw, 18-second stepper motor, 19-second slider, 20-L-type limit rod. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] The object of the present invention is to provide a rat tail vein injection device to solve the problems existing in the above-mentioned prior art and to enable accurate positioning and injection of the rat tail vein.

[0028] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0029] Reference Figure 1 , Attachment Figure 2 , Attachment Figure 3 and attached Figure 4 As shown, the present invention provides a mouse tail vein injection device, including a base 1, wherein four threaded legs are provided at the bottom of the base 1, so that the height of the legs can be adjusted by rotating the threads, thereby adjusting the height and levelness of the base 1; a fixing part, a positioning part and an injection part are provided on the base 1, wherein the fixing part can accommodate a mouse and fix the mouse tail; the positioning part is arranged above the fixing part, and can identify the vein position of the mouse tail; the injection part is arranged at one end of the fixing part, and can drive the injection needle 6 to inject a liquid medicine into the mouse tail vein according to the identified vein position of the mouse tail.

[0030] In one embodiment, in order to achieve the separate fixation of the mouse and its tail, the fixing part of this embodiment includes a mouse cage 2 and a mouse tail clamp 3. A long strip-shaped accommodating cavity is provided in the mouse cage 2, and the accommodating cavity is used to accommodate the mouse. The cross-sectional area of ​​the accommodating cavity is adjusted by bolts and other structures to adapt to and fix mice of different sizes; a mouse tail clamp 3 is provided at one end of the mouse cage 2. The mouse tail clamp 3 of this embodiment includes two symmetrically arranged magnet blocks. The end of the magnet block away from the mouse cage 2 is a smooth wedge-shaped structure. After the mouse is fixed in the mouse cage 2, its tail is extended from one end of the mouse cage 2 to between the two magnet blocks. The suction force of the two magnet blocks can be used to fix and clamp the mouse tail; due to the smooth wedge-shaped structure at the end of the magnet block, the fixed position of the mouse tail has a certain downward tilt direction, which makes it convenient for the injection needle 6 to inject the mouse tail at this position.

[0031] In order to locate the mouse tail vein, a blood vessel imager 5 or a blood vessel detector or an infrared detector is provided on the positioning bracket 4 of the positioning part of this embodiment. The blood vessel imager 5 can illuminate the mouse tail. There is blood flowing in the vein, so it presents a different color from the skin of other parts of the mouse tail. Therefore, the blood vessel imager 5 can identify the position of the vein based on the difference in color between the vein and other parts of the mouse tail by illuminating the mouse tail, and transmit the data to the control end. The control end can control the injection part to inject the drug solution into the mouse tail vein according to the data transmitted by the blood vessel imager 5.

[0032] In another embodiment, the vascular imager 5 can be replaced with an infrared camera, which is used to develop images and illuminate the mouse's tail, thereby identifying the mouse's tail image to determine its vein position. When the needle tip of the injection needle 6 is bent, after the mouse's tail vein position is determined by ordinary infrared detection, it is difficult for the first feeding device to accurately drive the needle to insert the vein. In this embodiment, an infrared camera is used to capture the mouse's tail image and transmit it to a computer. The computer is used to identify the vein position, and the fixing part can be controlled to move left and right so that the vein position is docked with the needle end, and then the first feeding device is driven to insert the needle end into the vein.

[0033] In order to make the vein position clearer and the positioning more accurate, the present embodiment is provided with a vertical slide rail on the positioning bracket 4, a vertical slide rail is slidably provided with a vertical slide, the vascular imager 5 is fixedly provided on the vertical slide, and the vertical slide is connected with a vertical driving device, which can drive the vertical slide to move up and down. The vertical driving device can adopt a lead screw nut pair, a vertical lead screw nut is provided on the vertical lead screw, the vertical lead screw nut is connected with the vertical slide, and the lead screw driving motor of the vertical lead screw is started, which can control the vertical lead screw nut and the vertical slide to move up and down synchronously, thereby adjusting the distance between the vascular imager 5 and the mouse tail; in addition, a linear motor 13 or a gear rack structure can also be used to adjust the up and down position of the vertical slide.

[0034] The injection part of this embodiment includes a first feeding device and a second feeding device. An injection needle 6 is fixed on the top of the first feeding device. The injection needle 6 is a mature structure, generally including a syringe, a needle is fixed at one end of the syringe, and a piston rod is movably inserted at the other end. The second feeding device is fixed at the end of the first feeding device. The first feeding device can drive the injection needle 6 and the second feeding device to move axially and horizontally, so that the needle head of the injection needle 6 can be inserted into the vein according to the position of the vein; the second feeding device can drive the piston rod of the injection needle 6 to move axially, and then the liquid medicine in the syringe of the injection needle 6 is injected into the vein through the needle.

[0035] The specific structures of the first feeding device and the second feeding device are not limited. In this embodiment, the first feeding device includes a first guide rail 7, two first guide rods 8 are arranged in the first guide rail 7, a first slider 11 is slidably arranged on the first guide rod 8, a first lead screw 9 is arranged between the two first guide rods 8, a lead screw nut on the first lead screw 9 is fixedly connected to the first slider 11, and one end of the first lead screw 9 is transmission-connected to a first stepper motor 10; a mounting plate 12 is fixedly arranged on the top of the first slider 11, a clamping groove is arranged at one end of the mounting plate 12, and a syringe for fixing and clamping the injection needle 6 in the clamping groove, and a second feeding device is arranged at the other end of the mounting plate 12, so that the injection needle 6 can be moved forward and backward through the lead screw nut pair. 6 and the second feeding device move axially synchronously. The control device adopts a mature computer, which can control the start and stop of the stepper motor according to the position of the vein, and then control the needle of the injection needle 6 to accurately pierce the vein of the mouse's tail. A push block 14 with a triangular structure is fixed at the end of the output shaft of the linear motor 13 of the second feeding device. When the linear motor 13 runs, it drives the push block 14 to move axially. The push block 14 can abut against the end of the piston rod of the injection needle 6, and then the push block 14 squeezes the piston rod to move in the syringe, so that the liquid medicine in the syringe is pushed into the vein through the needle to complete the injection; the linear motor 13 can also be replaced by a screw nut substructure, which can also drive the push block 14 to move horizontally.

[0036] In order to simplify the overall structure, in other embodiments, the second feeding device can be omitted, and the injection needle 6 can be replaced by a butterfly wing needle. The butterfly wing needle is fixed on the clamping groove of the mounting plate 12, and then the tail of the butterfly wing needle is connected to an injection pump through an infusion pipeline. When the first feeding device drives the tip of the butterfly wing needle to pierce the rat's tail vein, the injection pump is started to realize intravenous injection, and the injection process is more convenient.

[0037] Since there are two veins and two arteries distributed on the mouse tail, in order to achieve accurate docking between the injection needle 6 and the vein, in one embodiment, the fixing part is provided with a fixing bracket 15, and two second guide rods 16 are provided on the fixing bracket 15. A second slider 19 is slidably provided on the second guide rod 16, and a second lead screw 17 is provided between the two second guide rods 16. The lead screw nut on the second lead screw 17 is fixedly connected to the second slider 19, and one end of the second lead screw 17 is transmission-connected to a second stepping motor 18; a mouse cage 2 and a mouse tail clamp 3 are fixedly provided on the top of the second slider 19; the second guide rod 16 is arranged perpendicular to the axis of the injection part, so that the injection part can drive the needle of the injection needle 6 to move forward and backward, thereby realizing the needle insertion operation on the vein, and the second stepping motor 18 can control the mouse cage 2 and the mouse tail clamp 3 to move left and right, so that the mouse tail can better dock with the needle, which is convenient for the needle to be accurately inserted into the vein.

[0038] In order to further improve the positioning and docking accuracy of the rat tail vein and the needle, in one embodiment, a vertical pillar is provided on one side of the rat tail clamp 3, and an L-shaped limit rod 20 with a horizontal step is hinged on the top of the pillar. The L-shaped limit rod 20 is connected to the pillar through a torsion spring, and the needle is located near one end of the L-shaped limit rod 20. When the rat cage 2 and the rat tail clamp 3 move to one side, the outer side of the rat tail clamp 3 abuts and squeezes the L-shaped limit rod 20. At this time, the rat tail fixed by the rat tail clamp 3 is coaxial with the needle, which is convenient for injection operation. When the rat cage 2 and the rat tail clamp 3 move in the opposite direction, the L-shaped limit rod 20 is reset under the elastic force of the torsion spring. The reset L-shaped limit rod 20 can also play a certain protective role on the end of the needle to prevent the operator from accidentally touching the needle when not injecting.

[0039] In order to improve work efficiency, in one embodiment, the structure of the fixing portion can be further improved, and a turntable is set on the top of the second slider 19, and a plurality of mouse cages 2 are evenly distributed radially on the turntable. The outer end of each mouse cage 2 is equipped with a mouse tail clamp 3, so that when the first mouse cage 2 and the mouse tail clamp 3 are rotated to be coaxial with the injection portion, the injection operation begins, and new mice can be placed in other mouse cages 2 at the same time. After the injection of the mice in the first mouse cage 2 is completed, the turntable is rotated to immediately inject the mice in the second mouse cage 2. During the process, the mice in the first mouse cage 2 can be taken out and new mice can be put in synchronously, thereby realizing continuous and efficient injection operations and improving injection efficiency.

[0040] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only used to help understand the method and core ideas of the present invention. At the same time, for those skilled in the art, according to the ideas of the present invention, there will be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A rat tail vein injection device, characterized in that: include: A fixing part, which can accommodate a mouse and fix the tail of the mouse; A positioning part, disposed above the fixing part, capable of identifying the position of the vein of the mouse tail; The injection part is arranged at one end of the fixing part, and can drive the injection of intravenous injection liquid to the mouse tail according to the identified position of the mouse tail vein.

2. The rat tail vein injection device according to claim 1, characterized in that: The fixing part comprises a mouse cage and a mouse tail clamp. The mouse cage is used to accommodate and fix mice. One end of the mouse cage is provided with the mouse tail clamp, and the mouse tail clamp can fix and clamp the tail of the mouse.

3. The rat tail vein injection device according to claim 2, characterized in that: The mouse tail clamp comprises two symmetrically arranged magnet blocks, the end of the magnet block away from the mouse cage is a smooth wedge-shaped structure, and the two magnet blocks can fix and clamp the mouse tail.

4. The rat tail vein injection device according to claim 1, characterized in that: The positioning part includes a positioning bracket, on which a blood vessel imager is provided. The blood vessel imager can illuminate the mouse's tail to identify the location of the vein and transmit the data to a control end. The control end can control the injection part to inject a drug solution into the mouse's tail intravenously according to the data transmitted by the blood vessel imager.

5. The rat tail vein injection device according to claim 1, characterized in that: The injection part includes a first feeding device and a second feeding device. An injection needle is fixed on the top of the first feeding device, and the second feeding device is fixed on the end of the first feeding device. The first feeding device can drive the injection needle and the second feeding device to move axially and horizontally; the second feeding device can drive the piston rod of the injection needle to move axially.

6. The rat tail vein injection device according to claim 5, characterized in that: It also includes a base, and the fixing part, the positioning part and the injection part are all arranged on the base; and a plurality of legs are threadedly connected to the bottom of the base.

7. The rat tail vein injection device according to claim 5, characterized in that: The first feeding device includes a first guide rail, two first guide rods are arranged in the first guide rail, a first slider is slidably arranged on the first guide rod, a first lead screw is arranged between the two first guide rods, a lead screw nut on the first lead screw is fixedly connected to the first slider, and one end of the first lead screw is transmission-connected to a first stepper motor; a mounting plate is fixedly arranged on the top of the first slider, a clamping groove is arranged at one end of the mounting plate, and the clamping groove is used to fix and clamp the injection needle, and the second feeding device is arranged at the other end of the mounting plate.

8. The rat tail vein injection device according to claim 7, characterized in that: The second feeding device comprises a linear motor, and a push block is fixedly provided at the end of the output shaft of the linear motor, and the push block can abut against the end of the piston rod of the injection needle.

9. The rat tail vein injection device according to claim 4, characterized in that: The positioning bracket is provided with a vertical slide rail, a vertical slide is slidably provided on the vertical slide rail, the blood vessel imager is fixed on the vertical slide, the vertical slide is connected with a vertical driving device, and the vertical driving device can drive the vertical slide to move up and down.

10. The rat tail vein injection device according to claim 2, characterized in that: The fixing part also includes a fixing bracket, on which two second guide rods are provided, on which a second slider is slidably provided, a second lead screw is provided between the two second guide rods, a lead screw nut on the second lead screw is fixedly connected to the second slider, and one end of the second lead screw is transmission-connected to a second stepping motor; the squirrel cage and the rat tail clamp are fixedly provided on the top of the second slider; the second guide rod is arranged perpendicular to the axis of the injection part.

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