Cosmetic use of topically applicable rinse-off composition (RC)

Abstract

The present invention relates to the cosmetic use of a topically applicable rinse-off composition (RC) comprising as component (A) sandalwood pentanol (3-methyl-5-(2, 2, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3-pentanol); the present invention relates to a cosmetic composition comprising (A) one or more 1, 3, 3-trimethylcyclopent-3-en-1-yl) pent-2-ol) and / or one or more sandalwood pentanol analogs, (B) caffeine, (C) at least one C10-C18 fatty acid and / or a salt thereof, (D) at least one surfactant and (E) at least one cosmetically acceptable solvent for (i) improving the hair structure and (ii) reducing hair loss. In another aspect, the invention relates to non-therapeutic methods of (i) improving hair structure and (ii) alopecia using the topically applicable rinse-type composition (RC).

Description

Technical Field

[0001] The present invention relates to the cosmetic use of a topically administrable rinse-off composition (RC), comprising as components (A) sandal pentanol (3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more sandal pentanol analogs, (B) caffeine, (C) at least one C10-C18 fatty acid and / or its salt, (D) at least one surfactant and (E) at least one cosmetically acceptable solvent, for (i) improving hair structure and (ii) reducing hair loss. In another aspect, the present invention relates to a non-therapeutic method for (i) improving hair structure and (ii) reducing hair loss using the topically administrable rinse-off composition (RC). Background Art

[0002] The growth of human hair occurs in a known manner according to a natural growth rhythm, which includes a growth phase (anagen), a transition phase (catagen), a resting phase (telogen), and a release phase (exogen). The normal natural hair cycle begins with the base of the hair popping out or detaching during the shedding phase or popping out or detaching before a new anagen phase begins. During anagen, cells in the hair root divide rapidly, causing new hair to form, with a typical growth rate of about 0.3 to 0.4 mm / day for hair on the scalp. The anagen phase lasts about 2-6 years. After the anagen phase, catagen represents a short transition period in which hair growth stops and the blood supply to the cells causing hair growth is cut off. The catagen phase lasts about ten days. During the telogen phase (which lasts about 100 days), individual hairs remain in the follicles, but no longer actively grow. Finally, in the shedding phase, individual hairs pop out or release. The shedding period lasts about 2-5 months.

[0003] During normal hair growth, 80 to 100 hairs fall out of the scalp each day. This number is an approximation and can occur over a shorter period of time and can also be larger or smaller without causing concern for natural hair growth. However, when the amount of hair lost each day exceeds this approximate normal amount, irreversible or reversible hair loss is occurring.

[0004] WO2022 / 112419 discloses a composition comprising santalol, caffeine and one or more C10-C18 fatty acids. This composition can be used to reduce hair loss.

[0005] Any loss of hair volume over time is often perceived as "thinning hair", but such volume loss can be caused by different phenomena. One obvious cause for perceived thinner hair is alopecia, i.e., a decrease in the number or areal density of hair follicles that produce hair. Another cause for perceived thinner hair is a change in the growth cycle. For example, the percentage of hair in anagen and the duration of anagen may decrease, resulting primarily in shorter hair, but perceived as an overall loss of hair volume.

[0006] Another reason for perceived thinner hair is the variation in the diameter or cross section of the hair, i.e. the thinning of individual hairs. The structure and size of human head hair or scalp hair differs according to ethnic origin. Asian hair has a round uniform shape and an average diameter of 80 to 120 microns. Caucasian hair has an oval shape, with 60 to 80 microns being considered as the typical average diameter of hair. African hair has a flat oval shape, with an average diameter of 50 to 70 microns being considered typical. The average diameter also varies with age, with the diameter increasing until the 40s, and after that age, the average diameter decreases at an increasing rate. Summary of the invention

[0007] It is therefore an object of the present invention to provide a care product suitable for reducing hair loss together with improving hair structure, in particular including increasing the diameter or cross-section of the hair or improving keratin expression. Furthermore, there is a need for a care product suitable for improving the structure of hair affected by age-related hair thinning. In particular, there is a need for such a product which can be applied topically.

[0008] This object is achieved by the cosmetic use of a topically administrable rinse-off composition (RC) comprising as a component

[0009] (A) santalpentyl alcohol ((3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more santalpentyl alcohol analogs,

[0010] (B) Caffeine,

[0011] (C) at least one C10-C18 fatty acid and / or a salt thereof,

[0012] (D) at least one surfactant, and

[0013] (E) at least one cosmetically acceptable solvent,

[0014] Its use

[0015] (i) improve hair structure, and

[0016] (ii) Reduce hair loss.

[0017] According to a preferred aspect, the present invention provides the cosmetic use of a topically administrable rinse-off composition (RC) for improving hair structure (i) as well as reducing hair loss (ii), in particular the structure of mammalian hair such as human hair.

[0018] According to the present invention, it has now surprisingly been found that the combination of santalol, caffeine and at least one C10-C18 fatty acid and / or its salt is effective for improving hair structure (i) and reducing hair loss (ii). The inventors have found that the combination of santalol, caffeine and at least one C10-C18 fatty acid and / or its salt is suitable for reducing hair loss (ii) together with improving hair structure (i), wherein improving hair structure preferably comprises increasing the cross-section of the hair.

[0019] Furthermore, the inventors have found that the combination of santalopentol, caffeine and at least one C10-C18 fatty acid and / or its salt is suitable for improving hair structure, wherein improving hair structure (i) preferably comprises increasing keratin expression, in particular keratin 85 expression, together with reducing hair loss (ii). Furthermore, the inventors have found that the combination of santalopentol, caffeine and at least one C10-C18 fatty acid and / or its salt is suitable for improving the structure of hair affected by age-related hair thinning.

[0020] The cosmetic use of the topically-applicable rinse-off composition (RC) of the present invention is suitable for improving hair structure (i) together with reducing hair loss (ii). In one aspect, the cosmetic use of the topically-applicable rinse-off composition (RC) of the present invention is suitable for improving hair structure, wherein improving hair structure (i) comprises increasing the cross-section of the hair together with reducing hair loss (ii). In another aspect, the cosmetic use of the topically-applicable rinse-off composition (RC) of the present invention is suitable for improving hair structure (i), wherein improving hair structure comprises increasing the expression of keratin (e.g., the expression of keratin 85) together with reducing hair loss (ii). In yet another aspect, the cosmetic use of the topically-applicable rinse-off composition (RC) of the present invention is suitable for improving the structure of hair affected by age-related hair thinning together with reducing hair loss.

[0021] The cosmetic use of the topically administrable rinse-off composition (RC) according to the invention is also suitable for topical application to the human scalp. The cosmetic use of the topically administrable rinse-off composition (RC) according to the invention is suitable for cosmetic and therapeutic use in improving hair structure (i) as well as reducing hair loss (ii).

[0022] definition

[0023] In this specification, the terms "sandalol" and "Sandalore 210" are used interchangeably. Sandalol is a synthetic odorant that has a scent similar to that of sandalwood and is therefore used as a less expensive ingredient in perfumes, emollients and skin cleansers to mimic the scent of sandalwood. Sandalol and its structurally similar analogs, such as the compound known as brahmanol, are alcohols with a chemical structure that is distinct from the components of natural sandalwood oil, which are extracted from mature sandalwood trees by steam distillation and are well-known valuable components for perfumes. The IUPAC name for sandalol is 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol.

[0024] As used in the specification and the appended claims, the singular forms "a", "an", and "the" include plural references unless the context clearly dictates otherwise. The term "may" in the context of this application means "allowed to" or "able to", and is a synonym for the term "can". As used herein, the term "may" does not mean possibility or chance.

[0025] The term "and / or" in the context of this application means one or the other or both. For example, an aqueous solution of A and / or B means an aqueous solution of A alone, an aqueous solution of B alone, and an aqueous solution of A and B in combination.

[0026] The term "about" is understood as ±10% of the recited number, numbers or numerical range. According to an embodiment, the term "about" is understood as ±2% of the recited number, numbers or numerical range.

[0027] As used herein, the term "optionally" means that the corresponding step or feature may or may not be present. It includes both possibilities.

[0028] The terms "parts by weight" (PBW) and "parts by volume" (PBV) are used in their ordinary sense. When used in the context of mixing, e.g., when an amount of a component expressed in PBW is mixed with a component expressed in PBV, the terms PBW and PBV as used herein represent the amount of the component expressed in PBW (in grams) relative to the amount of the component expressed in PBV (in milliliters).

[0029] As used herein, the term "composition" means a mixture or blend comprising at least two components. A typical composition comprises at least one functional component (such as, for example, an active ingredient, such as santalol) and at least one solvent component (such as water or alcohol). The composition can exist in any suitable physical form, including, for example, liquids (with different viscosities), gels, foams, creams, etc. Unless the context dictates otherwise, the term "composition" can mean a ready-to-use product.

[0030] "Ready-to-use scalp and hair treatment product" means a form in which the composition is actually applied to the human scalp or area of ​​skin including facial hair.

[0031] The term "substantially free" of a particular component means that the amount of the corresponding component in the entity is less than 1.0 wt %, based on the total weight of the entity (such as a composition). In particular, the term "substantially free" means that the amount of the corresponding component in the entity is less than 0.5 wt %, for example less than 0.1 wt %, such as less than 0.01 wt %.

[0032] The term "free of" a particular component means an amount below the detection limit (assuming detectability is on a ppm (parts per million) basis (by weight)). In particular, the term "free of" a particular component means that the amount of the corresponding component in the entity is less than 50 ppm (by weight), for example less than 10 ppm (by weight), such as less than 5 ppm (by weight).

[0033] The term "consisting essentially of means that no additional, not specifically listed components are present in an entity (such as a composition) in an amount exceeding 1.0 wt % based on the total weight of the entity. In particular, the term "consisting essentially of means that no additional, not specifically listed components are present in an amount exceeding 0.5 wt %, such as exceeding 0.1 wt %, such as exceeding 0.01 wt % in the entity. It goes without saying that any additional, not specifically listed components are compatible with the specifically listed components and do not interfere with their function.

[0034] The term "consisting of" means that no additional, non-specifically listed components are present in an entity (such as a composition) in an amount below the detection limit (assuming detectability is on a ppm (parts per million) basis (by weight)). In particular, the term "consisting of" means that no additional, non-specifically listed components are present in an amount exceeding 50 ppm (by weight), for example exceeding 10 ppm (by weight), such as exceeding 10 ppm (by weight) in an entity. It goes without saying that any additional, non-specifically listed components are compatible with the specifically listed components and do not interfere with their function.

[0035] As used herein, the term "hair" refers generally to mammalian hair, but particularly to human hair. More specifically, for the purposes of the present invention, the term "hair" refers to human "head hair" or "scalp hair" as well as human "facial hair." The term "facial hair" encompasses beards, eyebrows, and eyelashes.

[0036] The term "improved hair structure" refers to an improvement in one or more structural phenomena of the hair. For example, "improved hair structure" encompasses an improved / enlarged "diameter" or "cross-section" of the "grown" hair. In another example, "improved hair structure" encompasses improved / increased keratin expression, in particular improved / increased expression of KRT85. The term "keratin 85" or "KRT85" refers to human keratin 85.

[0037] The term "age-related hair thinning" refers to the perceived loss of human hair volume caused by a decrease in hair diameter or cross-section that occurs in an age-dependent manner with an age of onset typically in the early 40s. Scientific studies have demonstrated that the age-dependent decrease in hair diameter or cross-section is associated with decreased keratin expression, including decreased KRT85 expression.

[0038] The term "KRT85 expression" refers to the expression of human keratin 85. Just outside the proliferative zone of stem cells (which many studies refer to as the "germinal matrix" or zone A), KRT85 appears as one of the first keratins expressed in cortical cells that form short filaments (paired with KRT35 or KRT31) in the cytoplasm of the "precortical hair matrix." KRT85 promotes the lateral association of short intermediate filaments (IFs) into bundles. These initial bundles are the first signs of keratin ultrastructure and are usually found in the cortex, approximately flush with the top of the dermal papilla. These intermediate filaments always exist as tightly packed bundles. As cortical cells move into zone B, the final fiber diameter and shape are determined as the Henle's layer hardens (inner root sheath). In zone C, the beginning of the keratinogenic zone, the final shape and position are maintained. This suggests that KRT85 expression is directly related to hair shaft mass, with increased KRT85 expression leading to an enlarged hair cross section. DETAILED DESCRIPTION

[0039] The inventors of the present invention surprisingly found that the combination of santalol (component (A)), caffeine (component (B)) and at least one C10-C18 fatty acid and / or its salt (component (C)) is effective for improving hair structure (i) and reducing hair loss (ii). The inventors of the present invention surprisingly found that santalol (component (A)), caffeine (component (B)) and at least one C10-C18 fatty acid and / or its salt (component (C)) are effective in a synergistic manner for improving hair structure (i) and reducing hair loss (ii).

[0040] Component (A)

[0041] In the present application, the terms “(A)”, “component (A)”, “santalol and / or one or more santalol analogs” are used synonymously and thus preferably have the same meaning.

[0042] Santalum amyl alcohol is one of the active ingredients used for improving hair structure (i) and reducing hair loss (ii) according to the present disclosure. Santalum amyl alcohol is a synthetic odorant used as an ingredient to mimic the smell of sandalwood. Santalum amyl alcohol is an alcohol whose chemical structure is very different from the components of natural sandalwood oil, which are usually extracted from mature sandalwood trees by steam distillation.

[0043] The IUPAC name of santalopentyl alcohol is 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol. Santalopentyl alcohol has been shown to have a stimulatory effect on the olfactory receptor OR2AT4, which is expressed in the epithelium of human hair follicles.

[0044] Analogs or derivatives of santalpentyl alcohol are believed to have similar effects on improving hair structure (i) and reducing hair loss, respectively, and may be used in the present disclosure alternatively or in addition to santalpentyl alcohol. Analogs of santalpentyl alcohol suitable as active ingredients include:

[0045] ·(4Z)-3-Methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol (Santalenol)

[0046] ·1-Methyl-2-((1,2.2-trimethylbicyclo(3.1.0)hex-3-yl)methyl)-cyclopropane-methanol (sandalyl cyclopropane)

[0047] ·(E)-3,3-Dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol (Santalol Pentenol)

[0048] ·2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)butanol (Santalinyl Cyclopentane)

[0049] ·(E)-2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol (sandalrome)

[0050] ·(E)-2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (santalol butenol)

[0051] According to an embodiment, in addition to the active ingredient santalopentol, the topically administrable rinse-off composition (RC) for use according to the present disclosure may also contain one or more of the above-mentioned santalopentol analogs. If present, the santalopentol plus one or more santalopentol analogs are present in the total amounts indicated below for santalopentol alone.

[0052] According to other embodiments, the topically administrable rinse-off composition (RC) for use according to the present disclosure may comprise santalopentol as an active ingredient and be substantially free of or free of the above-mentioned santalopentol analogs.

[0053] According to another less preferred embodiment, the topically administrable rinse-off composition (RC) for use according to the present disclosure may comprise one or more of the above-mentioned santalopentyl alcohol analogs in place of the active ingredient santalopentyl alcohol.

[0054] The amount of santalpentanol in the topically applicable rinse-off composition (RC) used according to the present disclosure is not particularly critical. Typically, based on the weight of the topically applicable rinse-off composition (RC), santalpentanol will be present in an amount of 0.010 to 10.0 weight %. If the amount is less than 0.010 weight %, the effect sought by the present disclosure may be difficult to achieve. An amount higher than 10.0 weight % may not further enhance the effect, but leads to a higher cost of material resources for the topically applicable rinse-off composition (RC) used according to the present disclosure. According to an embodiment, based on the weight of the topically applicable rinse-off composition (RC), santalpentanol may be present in an amount of 0.050 to 5.0 weight %. According to a more specific embodiment, based on the weight of the topically applicable rinse-off composition (RC), santalpentanol may be present in an amount of 0.10 to 2.0 weight %. According to an even more specific embodiment, based on the weight of the topically applicable rinse-off composition (RC), santalpentanol may be present in an amount of 0.50 to 1.50 weight %.

[0055] If an analogue of santalpentanol is present so as to at least partially replace santalpentanol or is present in addition to santalpentanol, the total amount of santalpentanol plus one or more santalpentanol analogues (as indicated above) is only within the range indicated above for santalpentanol.

[0056] Component (B)

[0057] In the present application, the terms “(B)”, “component (B)” and “caffeine” are used synonymously and thus preferably have the same meaning.

[0058] Caffeine is another active ingredient for improving hair structure (i) and reducing hair loss (ii) according to the present disclosure. Caffeine is a plant alkaloid, also known by the names theobromine, methyltheobromine and guaranaline. The IUPAC name is 1,3,7-trimethylxanthine. Caffeine is a well-known stimulant, which is found, for example, in coffee, black tea, but also in cocoa solids and products containing them (particularly dark chocolate) or kola nuts. Caffeine has a vasodilatory effect, thereby increasing the blood and nutrient supply to the hair root. Studies have shown that caffeine enhances hair shaft elongation (makes the hair root larger), prolongs the duration of anagen (increases the anagen phase), and stimulates the proliferation of hair matrix keratinocytes (increases keratin production).

[0059] The amount of caffeine in the topically-applicable rinse-off composition (RC) used according to the present disclosure is not particularly critical. If present, caffeine will typically be present in an amount of 0.010 to 10.0 wt % based on the weight of the topically-applicable rinse-off composition (RC). If the amount is less than 0.010 wt %, the effects sought by the present disclosure may be difficult to achieve. Amounts greater than 10.0 wt % may not further enhance the effect, but result in higher costs of material resources for the topically-applicable rinse-off composition (RC) used according to the present disclosure.

[0060] According to an embodiment, caffeine may be present in an amount of 0.050 to 5.0 wt % based on the weight of the topically-applicable rinse-off composition (RC). According to a more specific embodiment, caffeine may be present in an amount of 0.10 to 2.0 wt % based on the weight of the topically-applicable rinse-off composition (RC). According to an even more specific embodiment, caffeine may be present in an amount of 0.50 to 1.5 wt % based on the weight of the topically-applicable rinse-off composition (RC).

[0061] Component (C)

[0062] In the present application, the terms "(C)", "component (C)", "at least one C10-C18 fatty acid and / or its salt" are used synonymously and therefore preferably have the same meaning. "At least one C10-C18 fatty acid and / or its salt" means exactly one C10-C18 fatty acid and / or its salt and a mixture of two or more different C10-C18 fatty acids and / or their salts.

[0063] Another active ingredient for improving hair structure (i) and reducing hair loss (ii) according to the present disclosure is a C10-C18 fatty acid. One or more fatty acids for improving hair structure (i) and reducing hair loss (ii) are one or more straight and / or branched saturated and / or unsaturated C10-C18 fatty acids. Typically, one or more C10-C18 fatty acids will be straight chain fatty acids. According to an embodiment, one or more C10-C18 fatty acids can be selected from capric acid (C10:0), lauric acid (C12:0), myristic acid (C14:0), isomyristic acid (C14:0), palmitic acid (C16:0), palmitoleic acid (C16:1), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1) or a combination thereof, and / or their salts.

[0064] According to an embodiment, one or more C10-C18 fatty acids may include lauric acid (C12:0), myristic acid (C14:0) or a combination thereof. According to a specific embodiment, one or more C10-C18 fatty acids may be selected from lauric acid (C12:0), myristic acid (C14:0) or a combination thereof. For example, the fatty acid component of the active ingredient combination may be lauric acid (C12:0) and / or a salt thereof.

[0065] According to an embodiment, the fatty acid component can include one or more unsaturated fatty acids. According to an embodiment, one or more C10-C18 fatty acids can include palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), octadecatetraenoic acid (C18:4), petroselinic acid (C18:1) or its combination. For example, the fatty acid component can include linoleic acid (C18:2) and / or its salt.

[0066] According to a specific embodiment, the fatty acid component can be selected from palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), octadecatetraenoic acid (C18:4), petroselinic acid (C18:1) or a combination thereof. For example, the fatty acid component can be selected from palmitoleic acid (C16:1) and / or linoleic acid (C18:2), and / or their salts.

[0067] If the fatty acid component comprises one or more unsaturated fatty acids, the corresponding composition preferably comprises an antioxidant to reduce auto-oxidation of double bonds.

[0068] According to an embodiment, the topically administrable rinse-off composition (RC) used according to the present disclosure may be substantially free or free of unsaturated C10-C18 fatty acids. According to a specific embodiment, the composition according to the present disclosure may be substantially free or free of unsaturated fatty acids per se.

[0069] If present, the one or more C10-C18 fatty acids may be present in the form of free acids, or in the form of cosmetically acceptable salts, such as alkali metal salts, alkaline earth metal salts, ammonium salts, or combinations thereof. For example, if present, the one or more C10-C18 fatty acids may be present in the form of one or more free acids.

[0070] The amount of one or more C10-C18 fatty acids in the topically applicable rinse-off composition (RC) used according to the present disclosure is not particularly critical. If present, one or more C10-C18 fatty acids will typically be present in an amount of 0.010 to 10.0 wt % based on the weight of the topically applicable rinse-off composition (RC). If the amount is less than 0.010 wt %, the effects sought by the present disclosure may be difficult to achieve. Amounts greater than 10.0 wt % may not further enhance the effect, but result in higher costs of material resources for the topically applicable rinse-off composition (RC) used according to the present disclosure.

[0071] High amounts of one or more C10-C18 fatty acids may also require higher amounts of surfactants (component (D)) and may result in a greasy appearance or hair feel. According to an embodiment, one or more C10-C18 fatty acids may be present in an amount of 0.050 to 3.0 wt.-%, based on the weight of the topically applicable rinse-off composition (RC). According to a more specific embodiment, the C10-C18 fatty acids may be present in an amount of 0.05 to 1 wt.-%, based on the weight of the topically applicable rinse-off composition (RC). According to an even more specific embodiment, the C10-C18 fatty acids may be present in an amount of 0.1 to 0.3 wt.-%, based on the weight of the topically applicable rinse-off composition (RC) used.

[0072] Component (D)

[0073] In the present application, the terms "(D)", "component (D)" and "at least one surfactant" are used synonymously and therefore preferably have the same meaning. The term "at least one surfactant" means exactly one surfactant, as well as mixtures of two or more different surfactants.

[0074] Surfactants suitable as component (D) include anionic, cationic, amphoteric and nonionic surfactants.

[0075] The anionic surfactant may be selected from the group consisting of salts of the following compounds (such as alkaline salts, e.g., sodium, ammonium, amine, aminoalcohol and magnesium salts): alkyl sulfates, alkyl ether sulfates, alkyl amido ether sulfates, alkyl aryl polyether sulfates, monoglyceride sulfates; alkyl sulfonates, alkyl phosphates, alkyl amide sulfonates, alkyl aryl sulfonates, α-olefin sulfonates, paraffin sulfonates; alkyl sulfosuccinates, alkyl ether sulfosuccinates, alkyl amide sulfosuccinates; alkyl sulfosuccinamates; alkyl sulfoacetates; alkyl ether phosphates; acyl sarcosinates; acyl isethionates; N-acyl taurates; and mixtures thereof. The alkyl or acyl groups of all these various compounds contain, for example, 8 to 24 carbon atoms, and the aryl groups are, for example, selected from phenyl and benzyl. Weak anionic surfactants such as alkyl-D-galactosiduronic acid and its salts, and polyoxyalkylene (C6-C24) alkyl ether carboxylic acids, polyoxyalkylene (C6-C24) alkyl aryl ether carboxylic acids, polyoxyalkylene (C6-C24) alkyl amido ether carboxylic acids and their salts (e.g., those containing 2 to 50 ethylene oxide groups), and mixtures thereof may also be used. Anionic derivatives of polysaccharides, such as carboxyalkyl ethers of alkyl polyglucosides, may also be used.

[0076] Suitable one or more anionic surfactants (component (D)) may contain at least one anionic functional group in its head selected from sulfate, sulfonate, phosphate and carboxylate. In order to avoid any overlap with the active ingredient combination of the present disclosure, the one or more anionic surfactants used in the composition according to the present disclosure do not include fatty acids or their salts.

[0077] Suitable alkyl sulfates include ammonium lauryl sulfate, sodium lauryl sulfate (sodium dodecyl sulfate, SLS or SDS) and alkyl ether sulfates, such as sodium laureth sulfate (sodium lauryl ether sulfate or SLES) and sodium myreth sulfate. Other suitable anionic surfactants can include docusate (dioctyl sodium sulfosuccinate), alkyl aryl ether phosphates, alkyl ether phosphates, sodium lauroyl sarcosinate, ammonium laureth sulfate, disodium lauryl sulfosuccinate and sodium lauryl sulfoacetate.

[0078] Preferred anionic surfactants may be selected from the group consisting of sodium lauryl ether sulfate, sodium laurethether sulfate, sodium dodecyl sulfate, ammonium laureth sulfate, ammonium dodecyl sulfate, alkylbenzene sulfonates, and combinations thereof.

[0079] Surfactant can be nonionic surfactant.Nonionic surfactant can be selected from the group consisting of the following: lanolin alcohol, and the polyoxyethylene ether of fatty alcohol, and their mixture.Nonionic surfactant can preferably be cetearyl alcohol polyoxyethylene ether (ceteareth)-n, wherein n is 2 to 100 or 10 to 30.Suitable nonionic surfactant is a well-known compound (see, for example, in this regard, MR Porter's " Handbook of Surfactants (Surfactant Handbook) ", published by Blackie & Son (Glasgow and London), 1991, pp.116-178).Preferred surfactants cover nonionic surfactants, particularly polyoxyethylated (polyoxyethylated) fatty alcohol or oil.Particularly preferred nonionic surfactants include polyoxyethylated castor oil and hydrogenated polyoxylated (polyoxylated) castor oil.The specific example of the nonionic surfactant that can be used in the composition of the present disclosure is PEG-35 castor oil, PEG-40 hydrogenated castor oil and combination thereof.

[0080] Component (D) is preferably present in an amount of 5 to 30 wt. %, more preferably in an amount of 10 to 25 wt. % and particularly preferably in an amount of 12 to 20 wt. %, wherein the wt. % values ​​are based on the total weight of the topically administrable rinse-off composition (RC).

[0081] Component (E)

[0082] In the present application, the terms "(E)", "component (E)" and "at least one cosmetically acceptable solvent" are used synonymously and therefore preferably have the same meaning. The term "at least one cosmetically acceptable solvent" means exactly one cosmetically acceptable solvent, as well as mixtures of two or more different cosmetically acceptable solvents.

[0083] The cosmetically acceptable solvent for the topically administrable rinse-off composition (RC) is preferably water-based, alcohol-based or water-alcohol-based. Typically, the cosmetically acceptable solvent comprises water and one or more monovalent and / or multivalent C1-C4 alcohols. According to an embodiment, the solvent comprises water and an alcohol selected from ethanol, n-propanol, isopropanol, glycerol, ethylene glycol, propylene glycol or a combination thereof.

[0084] Preferred as component (E) are water, glycerol or a mixture of water and glycerol.

[0085] Component (E) is preferably present in an amount of 45 to 94.97 wt.-%, based on the total weight of the topically administrable rinse-off composition (RC).

[0086] In a preferred embodiment, component (E) comprises at least 50% by weight, more preferably at least 70% by weight and particularly preferably at least 80% by weight of water, based on the total weight of component (E) contained in the topically administrable rinse-off composition (RC).

[0087] In another preferred embodiment, component (E) comprises at least 50 wt.-%, more preferably at least 70 wt.-% and particularly preferably at least 80 wt.-% glycerol, based on the total weight of component (E) contained in the topically administrable rinse-off composition (RC).

[0088] Optional additional components

[0089] The topically-applicable rinse-off composition (RC) used according to the present disclosure may optionally include additional components that enhance, supplement or increase the benefit obtained by santalpentyl alcohol alone or in combination of active ingredients. Such additional optional components will be referred to as support components, oil components and mineral components hereinafter. Support components encompass a wide range of materials that have a diverse impact on physiology or metabolic processes. Oil components encompass natural essential oils and modified oils. Modified oils include hydrogenated oils and oil constituents in particular. Mineral components encompass minerals in water-soluble or alcohol-soluble forms.

[0090] According to an embodiment, the composition according to the present disclosure may further comprise a supporting component. Examples of such supporting components include in particular vasodilators, blood circulation stimulants, antioxidants, vitamins, provitamins. If present, the amount of the supporting component or a combination thereof will be in the range of 0.0010 to 5.0 wt %, in particular 0.010 to 3.0 wt %, based on the weight of the topically administrable rinse-off composition (RC).

[0091] Support components can include, for example, one or more of tocopherols, tocotrienols, tocopherol esters, niacin, niacinamide, nicotinic acid esters, vasodilating plant extracts, camphor, royal jelly, biotin, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, vitamin K1, vitamin K2, panthenol (provitamin B5), omega-3 fatty acids, omega-6 fatty acids, folic acid (folate), amino acids, or a combination thereof.

[0092] According to an embodiment, the support component includes a vasodilator selected from the following: tocopherol (α-, β-, γ- or δ-tocopherol) (particularly α-tocopherol), tocopherol esters (including, for example, tocopherol acetate, tocopherol succinate, tocopherol nicotinate, tocopherol poly(ethylene oxide)-succinate), nicotinic acid, niacinamide, nicotinic acid esters, camphor; antioxidants, such as vitamin C or one or more polyphenols; inhibitors of testosterone-5-α-reductase, such as the ω-6 fatty acid arachidonic acid; substances that provide benefits for hair health, such as niacinamide (nicotinamide); or combinations thereof. According to an embodiment, the support component includes tocopherol or tocopherol acetate (vitamin E acetate) and / or niacinamide. Suitable vasodilating plant extracts include burnt or distilled nettle extract (Urtica Diocia), roasted chestnut extract (Aesculus Hippocastanum), Arnica extract (Arnica Montana).

[0093] The oil component may include, for example, peppermint oil, rosemary essential oil, lavender essential oil, tea tree oil, ylang-ylang, thyme oil, cedarwood oil, clary sage essential oil, bergamot oil, jojoba oil, sunflower oil, hydrogenated ethylhexyl olivetate, or a combination thereof. If present, the oil component will be present in the composition of the present disclosure in an amount of 0.0010 to 1.0 wt. %, specifically 0.010 to 0.50 wt. %, based on the weight of the topically administrable rinse-off composition (RC).

[0094] According to an embodiment, the oil component comprises peppermint oil and / or hydrogenated ethylhexyl olivetate.

[0095] The mineral component includes metal ions that have beneficial effects on hair and / or scalp health. The mineral component may include, for example, iron, zinc, or a combination thereof. If present, the mineral component will be present in the composition of the present disclosure at a concentration of 0.0050-0.50 molar, for example, at a concentration of 0.010-0.25 molar.

[0096] The topically administrable rinse-off composition (RC) used in accordance with the present disclosure may comprise a support component, an oil component, or a mineral component, alone or in any combination.

[0097] The topically administrable rinse-off composition (RC) used according to the present disclosure may optionally contain cosmetically acceptable additives that may help achieve or enhance the desired properties or effects. According to an embodiment, cosmetically acceptable additives may be selected from fragrances, sunscreens, preservatives, pH adjusters, chelating agents, hair care materials or skin care materials, physiologically compatible organosilicon derivative compounds, light protectants, anti-stripping agents, hair gloss imparting agents, combability improvers, degreasing agents, humectants, conditioners, viscosity modifiers, cooling agents. Cosmetically acceptable additives may be used in any combination as needed or desired.

[0098] Suitable cosmetically acceptable additives not specifically described below are listed in the International Cosmetics Ingredient Dictionary and Handbook (8th Edition; The Cosmetics, Toiletry, and Fragrance Association). In particular, Volume 2, Sections 3 (Chemical Class) and 4 (Function), which can be used to identify specific additives to achieve a particular purpose or purposes. Some of these additives are discussed below, and their disclosure is of course non-exhaustive.

[0099] Suitable amount ranges of fragrances, sunscreens, preservatives, pH regulators, chelating agents, hair care materials or skin care materials, physiologically compatible organosilicon derivative compounds, light protectants, anti-flaking agents, hair gloss imparting agents, combability improving agents, degreasing agents, moisturizers, conditioners, viscosity modifiers, cooling agents are indicated below for the additives discussed. Based on the weight of the topically applicable rinse-off composition (RC), these cosmetically acceptable additives can be present in a total amount of up to 20.0% by weight, especially up to 15.0% by weight. Typically, based on the weight of the topically applicable rinse-off composition (RC), the total amount of these cosmetically acceptable additives can be in the range of 0.010 to 10.0% by weight, conveniently in the range of 0.010 to 7.0% by weight. For example, based on the weight of the topically applicable rinse-off composition (RC) used, the total amount of these cosmetically acceptable additives can be in the range of 0.010 to 5.0% by weight, conveniently in the range of 0.010 to 3.0% by weight.

[0100] The topically-applicable rinse-off composition (RC) used according to the present disclosure may include a fragrance or flavor. For example, the topically-applicable rinse-off composition (RC) may include 0.0010 to 1.50 wt %, particularly 0.010-0.50 wt %, of a fragrance based on the weight of the topically-applicable rinse-off composition (RC). The fragrance may provide an enhanced user experience by making the composition smell pleasant and / or evoke emotions, such as a relaxing or exciting scent.

[0101] Alternatively, the topically-applicable rinse-off composition (RC) used in accordance with the present disclosure may be substantially free of fragrances and / or flavors. Some consumers prefer compositions free of fragrances. The fragrance may be an animal fragrance or a plant fragrance. The animal fragrance may be selected from the group consisting of: musk oil, civet, castoreum, ambergris, and mixtures thereof.

[0102] The botanical fragrance can be selected from the group consisting of nutmeg extract, cardamom extract, ginger extract, cinnamon extract, patchouli oil, geranium oil, orange oil, citrus oil, orange blossom extract, cedarwood, vetiver, lavandin, ylang-ylang extract, tuberose extract, sandalwood oil, bergamot oil, rosemary oil, spearmint oil, peppermint oil, lemon oil, lavender oil, citronella oil, chamomile oil, clove oil, sage oil, neroli oil, labdanum oil, eucalyptus oil, verbena oil, mimosa extract, narcissus extract, carrot seed extract, jasmine extract, frankincense extract, rose extract, and mixtures thereof.

[0103] The fragrance may include one or more fragrances selected from the group consisting of acetophenone, adoxal, aldehyde C-12, aldehyde C-14, aldehyde C-18, allyl octanoate, ambroxan, amyl acetate, dimethyl indane derivatives, α-amyl cinnamaldehyde, anethole, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol and ester derivatives, benzyl propionate, benzyl salicylate, borneol, butyl acetate, camphor, carbitol, cinnamaldehyde, cinnamyl acetate, cinnamyl alcohol, cis-3-hexanol and ester derivatives, cis-3-hexenyl methyl carbonate, citral, citronellol and ester derivatives, cuminaldehyde, cyclamen aldehyde, cyclo galbanate, damascones, decalactone, decanol, estragole, dihydromyrcenol, dimethylbenzyl alcohol, 6,8-dimethyl-2-nonanol, dimethylbenzyl methyl butyrate, ethyl acetate, ethyl isobutyrate, ethyl butyrate, ethyl propionate, ethyl octanoate, ethyl cinnamate, ethyl caproate, ethyl valerate, ethyl vanillin, eugenol, exaltolide, fenchone, fruity esters such as ethyl 2-methylbutyrate, galaxolide, geraniol and ester derivatives, helional, 2-heptonone, hexenol, α-hexylcinnamaldehyde, hydroxycitrolnellal, indole, isoamyl acetate, isoeugenol acetate, ionones, isoeugenol, isoamyl isovalerate, ambergris super), limonene, linalool, lilial, linalyl acetate, lyral, majantol, mayol, melonal, menthol, p-methylacetophenone, methyl anthranilate, methyl cedrylone, methyl dihydrojasmonate, methyl eugenol, methyl ionone ionone), methyl-α-naphthyl ketone, methyl phenyl methyl acetate, mugetanol, γ-nonalactone, octanal, phenylethyl acetate, phenylacetaldehyde dimethyl acetate, phenoxyethyl isobutyrate, phenylethyl alcohol, pinene, sandalore, santalol, stemone, thymol, terpenes, triplal, triethyl citrate, 3,3,5-trimethylcyclohexanol, γ-undecanoic acid lactone, undecenal, vanillin, veloutone, verdox and mixtures thereof.

[0104] The topically administrable rinse-off composition (RC) used in accordance with the present disclosure may contain a sunscreen, which is sometimes also represented by the term "turbidity inducing agent". For example, based on the weight of the topically administrable rinse-off composition (RC), the composition may contain 0.10 to 5.0 wt%, in particular 0.50-2.0 wt% of a sunscreen. Suitable sunscreens include mineral pigments such as, for example, titanium dioxide, aluminum oxide, calcium carbonate. Other suitable sunscreens include fatty alcohols and fatty acid esters such as, for example, cetearyl alcohol, cetyl alcohol, glycol distearate, glyceryl stearate, glyceryl oleate, stearyl stearate.

[0105] The topically administrable rinse-off composition (RC) used according to the present disclosure may contain a preservative or a mixture of preservatives. Based on the weight of the topically administrable rinse-off composition (RC), the composition may contain one or more preservatives in an amount of up to 1.0 wt %, for example 0.0010 to 1.0 wt %, in particular 0.010 to 0.50 wt %. Cosmetically acceptable preservatives include organic acids such as p-hydroxybenzoic acid; organic acid salts such as sodium benzoate; compounds such as benzyl alcohol, phenoxyethanol, 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione; and mixtures thereof.

[0106] The topically administrable rinse-off composition (RC) used according to the present disclosure may include a pH adjuster and / or a buffer in an amount sufficient to effectively adjust the pH of the composition. For example, based on the weight of the topically administrable rinse-off composition (RC), the composition may include up to 1.0 wt%, such as 0.000010 to 1.0 wt%, particularly 0.0010 to 0.50 wt% of a pH adjuster. Suitable pH adjusters and / or buffers for use herein include, but are not limited to, ammonia; alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, tripropanolamine, 2-amino-2-methyl-1-propanol, and 2-amino-2-hydroxymethyl-1,3,-propanediol; and guanidine salts, alkali metal hydroxides and carbonates, and ammonium hydroxides and carbonates, such as sodium hydroxide, sodium silicate, sodium metasilicate, and ammonium carbonate; and acids, such as organic and inorganic acids, for example, ascorbic acid, citric acid, acetic acid or tartaric acid, phosphoric acid, hydrochloric acid, and mixtures thereof.

[0107] Preferred alkaline pH adjusters include ammonia, ethanolamine and alkali metal hydroxides, especially sodium hydroxide. Preferred acidic pH adjusters include hydrochloric acid, ascorbic acid or citric acid.

[0108] The topically-applicable rinse-off compositions (RC) used in accordance with the present disclosure may also include one or more chelators (also referred to as "chelating agents / chelants" or "sequestering agents / sequestrants") in an amount sufficient to reduce the amount of metal available for interaction with the formulation components. Chelators are well known in the art, and a non-exhaustive list thereof can be found in AE Martell & RM Smith, Critical Stability Constants, Vol. 1, Plenum Press, New York & London (1974) and AE Martell & RD Hancock, Metal Complexes in Aqueous Solutions, Plenum Press, New York & London (1996). Typically, the composition may include one or more chelators in a total amount of 0.0010 to 1.0 wt %, particularly 0.010 to 0.50 wt %, based on the weight of the topically-applicable rinse-off composition (RC).

[0109] One or more chelating agents may be selected from the group consisting of carboxylic acids (such as aminocarboxylic acids), phosphonic acids (such as aminophosphonic acids), polyphosphoric acids (such as linear polyphosphoric acids), salts thereof and mixtures thereof. In the context of chelating agents, "salts thereof" means all salts containing the same functional structure as the chelating agents to which they refer, and includes alkali metal salts, alkaline earth metal salts, ammonium salts, substituted ammonium salts and mixtures thereof; alternatively sodium salts, potassium salts, calcium salts, magnesium salts, ammonium salts and mixtures thereof; alternatively monoethanolammonium salts, diethanolammonium salts, triethanolammonium salts and mixtures thereof.

[0110] One or more chelating agents can be one or more aminocarboxylic acid chelating agents comprising one or more carboxylic acid moieties (-COOH) and one or more nitrogen atoms. One or more aminocarboxylic acid chelating agents can be selected from the group consisting of diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), ethylenediamine-N,N'-diglutaric acid (EDDG), 2-hydroxypropylenediamine-N-N'-disuccinic acid (HPDDS), glycinamide-N,N'-disuccinic acid (GADS), ethylenediamine-N-N'-diglutaric acid (EDDG), 2-hydroxypropylenediamine-N-N'-disuccinic acid (HPDDS), ethylenediaminetetraacetic acid (EDTA), ethylenedisulfoalanine (EDC), ethylenediamine-N-N'-bis(o-hydroxyphenylacetic acid) (EDDHA), diaminoalkyldi(sulfosuccinic acid) (DDS), N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED), their salts and mixtures thereof. Conveniently, the chelating agent (if any) used in the compositions according to the present disclosure may be EDTA.

[0111] The topically-applicable rinse-off composition (RC) used according to the present disclosure may contain a viscosity modifier (also referred to in the art as a "thickener"). If present, such a viscosity modifier will typically be used in an amount of 0.010 to 3.0 wt. %, particularly 0.50 to 1.0 wt. %, based on the weight of the topically-applicable rinse-off composition (RC). Suitable cosmetically acceptable viscosity modifiers include nonionic polymers, for example polysaccharides such as cellulose, cellulose gum or xanthan gum, and polyether-1-based nonionic viscosity modifiers such as the commercially available viscosity modifier Pure Thix 1442.

[0112] The topically-applicable rinse-off composition (RC) used according to the present disclosure may also contain care materials, such as plant or vegetable extracts, cationic polymers or cationic surfactants that provide hair care or skin care. The typical amount of care materials in the composition according to the present disclosure will be in the range of 0.010 to 5.0 wt. %, particularly 0.050-2.0 wt. %, based on the weight of the topically-applicable rinse-off composition (RC).

[0113] Additional cosmetically acceptable additives that may be present in the topically administrable rinse-off compositions (RC) used in accordance with the present disclosure include:

[0114] Physiologically compatible silicone derivative compounds, such as volatile or non-volatile silicones or high molecular weight siloxane polymers, such as, for example, Quaternium-80, typically in amounts of 0.05 to 20% by weight, particularly 0.10 to 5.0% by weight, based on the weight of the composition

[0115] Photoprotectants, such as, for example, octyl methoxycinnamate

[0116] Anti-stripping agents, typically in amounts of about 0.01 to 2% by weight

[0117] Hair gloss-imparting agents, such as, for example, phenyl trimethicone,

[0118] Combability improvers, such as, for example, cationic surfactants such as behentrimonium chloride, or cationic polymers such as polyquaternium-10

[0119] Degreasing agent

[0120] Conditioning agent

[0121] Humectants, such as, for example, sodium lactate, sodium PCA, glycine, fructose, urea, niacinamide, inositol

[0122] Coolants, such as, for example, menthol, eucalptol, geraniol, linalool, isopulegol, cubedol, p-menthane-3,8-diol, hydroxycitronellal and its esters and derivatives; ketones, such as menthone and carvone; carboxamides, or evaporative coolants

[0123] Cosmetically acceptable additives may be used in any combination as needed or desired in the topically administrable rinse-off composition (RC) for use according to the present disclosure.

[0124] Substances that may be excluded

[0125] Topically administrable rinse-off compositions (RC) used in accordance with the present disclosure may be substantially free or free of certain substances or classes of chemical compounds.

[0126] According to an embodiment, the topically administrable rinse-off composition (RC) for use according to the present disclosure may be substantially free of biotin. According to an embodiment, the topically administrable rinse-off composition (RC) for use according to the present disclosure may be free of biotin. According to a particular embodiment, the concentration of biotin may be less than 5 ppm (by weight).

[0127] According to an embodiment, the topically-applicable rinse-off composition (RC) used according to the present disclosure may be substantially free of quaternary ammonium compounds. According to an embodiment, the topically-applicable rinse-off composition (RC) used according to the present disclosure may be free of quaternary ammonium compounds. According to a particular embodiment, the concentration of quaternary ammonium compounds may be less than 5 ppm (by weight).

[0128] According to an embodiment, the topically administrable rinse-off composition (RC) used according to the present disclosure may be substantially free of silicone. According to an embodiment, the composition according to the present disclosure may be free of silicone. According to a particular embodiment, the concentration of silicone may be less than 5 ppm (by weight).

[0129] According to an embodiment, the topically-applicable rinse-off composition (RC) used according to the present disclosure may be substantially free of quaternary ammonium compounds and silicones. According to an embodiment, the topically-applicable rinse-off composition (RC) used according to the present disclosure may be free of quaternary ammonium compounds and silicones. According to a particular embodiment, the concentration of quaternary ammonium compounds and silicones may be less than 5 ppm (by weight).

[0130] According to an embodiment, the polymer compounds present in the topically administrable rinse-off composition (RC) for use according to the present disclosure are only film-forming polymers. In other words, according to an embodiment, the topically administrable rinse-off composition (RC) for use according to the present disclosure may be substantially free of non-film-forming polymers. According to an embodiment, the topically administrable rinse-off composition (RC) for use according to the present disclosure may be free of non-film-forming polymers. According to a particular embodiment, the concentration of non-film-forming polymers may be less than 5 ppm (by weight).

[0131] According to an embodiment, the topically administrable rinse-off composition (RC) used according to the present disclosure may be substantially free or free of non-film-forming polymers selected from the group consisting of acrylates / steareth-20 methacrylate copolymer, carbomer, polyacrylamide, hydroxyethylcellulose, xanthan gum, and polymers of similar chemical properties.

[0132] According to an embodiment, the topically administrable rinse-off composition (RC) for use according to the present disclosure may be substantially free or free of unsaturated fatty acids.

[0133] Topical rinse-off composition (RC)

[0134] Typically, santalpentyl alcohol (component (A)) will be present in an amount of 0.010 to 10.0 wt % based on the weight of the topically-applicable rinse-off composition (RC). Typically, caffeine (component (B)) will be present in an amount of 0.010 to 10.0 wt % based on the weight of the topically-applicable rinse-off composition (RC). At least one C10-C18 fatty acid and / or salt thereof (component (C)) will typically be present in an amount of 0.010 to 2.0 wt % based on the weight of the topically-applicable rinse-off composition (RC). Conveniently, santalpentyl alcohol (component (A)) will be present in an amount of 0.10 to 5.0 wt %, caffeine (component (B)) will be present in an amount of 0.10 to 5.0 wt %, and at least one C10-C18 fatty acid (component (C)) will be present in an amount of 0.050 to 3.0 wt % (each based on the weight of the topically-applicable rinse-off composition (RC)).

[0135] According to an embodiment, santalpentanol (component (A)) will be present in an amount of 0.50 to 2.0 wt. %, caffeine (component (B)) will be present in an amount of 0.50 to 2.0 wt. %, and at least one C10-C18 fatty acid (component (C)) will be present in an amount of 0.10 to 2.0 wt. % (each based on the weight of the topically applicable rinse-off composition (RC)). According to a more specific embodiment, santalpentanol (component (A)) will be present in an amount of 0.80 to 1.50 wt. %, caffeine (component (B)) will be present in an amount of 0.80 to 1.50 wt. %, and at least one C10-C18 fatty acid (component (C)) will be present in an amount of 0.10 to 1.0 wt. % (each based on the weight of the topically applicable rinse-off composition (RC)).

[0136] According to an embodiment encompassing a combination of santalol (component (A)), caffeine (component (B)), and at least one C10-C18 fatty acid (component (C)), the weight ratio of santalol to caffeine may be 1:2 to 2:1, more specifically 1:1.5 to 1.5:1, and especially 1:1.2 to 1.2:1. In such an embodiment, the weight ratio of santalol to at least one C10-C18 fatty acid may be 10:1 to 1:1, more specifically 8:1 to 1.5:1, and especially 5:1 to 2:1. In addition, the weight ratio of caffeine to at least one C10-C18 fatty acid may similarly be 10:1 to 1:1, more specifically 8:1 to 1.5:1, and especially 5:1 to 2:1. Given that the molecular weights of santalol, caffeine, and C10-C18 fatty acids are fairly similar, the molecular ratios will be similar to the weight ratios.

[0137] The topically administrable rinse-off composition (RC) used in the present disclosure may have a pH in the range of 3.0 to 8.0. According to an embodiment, the pH may be in the range of 4.0 to 6.5, such as in the range of 4.5 to 6.0.

[0138] The topically-applicable rinse-off composition (RC) used in the present invention is preferably at least one composition selected from the group consisting of a hair lotion, a hair conditioner, a hair cream, a hair shampoo, a dry shampoo, a hair foam and a shampoo bar.

[0139] In a preferred embodiment, the topically administrable rinse-off composition (RC) is a shampoo or a conditioner.

[0140] Non-therapeutic methods

[0141] Another aspect of the present invention is a non-therapeutic method for (i) improving hair structure and (ii) reducing hair loss, comprising the steps of:

[0142] a) Rinse the hair and scalp with water,

[0143] b) applying topically to the hair and scalp a rinse-off composition (RC) as described herein for a period of at least 1 minute, preferably at least 2 minutes,

[0144] c) rinsing the hair and scalp with water to remove the rinse-off composition (RC) as described herein from the hair and scalp,

[0145] Wherein steps a), b) and c) are performed at least once within a period of 48 hours, preferably at least once within a period of 24 hours.

[0146] Hereinafter, the terms "topically-applicable rinse-off composition (RC)" and "composition (RC)" will be used synonymously. The topically-applicable rinse-off composition (RC) used according to the present disclosure may be employed according to a method in which the composition (RC) is applied to at least a portion of the scalp area, or to at least a portion of the skin area including facial hair. Conveniently, the composition (RC) may be applied to at least a portion of the scalp area, or to at least a portion of the skin area including facial hair, and subsequently or simultaneously gently worked in.

[0147] Preferably, the composition (RC) is gently applied after the hair and scalp have been rinsed with water. The composition (RC) used according to the present disclosure is applied in an amount sufficient to obtain the desired effects (i and ii). In particular, the composition (RC) can be applied to at least a portion of the scalp area, or to at least a portion of the skin area including facial hair, to deliver an effective amount of the active ingredient combination, namely a combination of santalol (component (A)), caffeine (component B)) and at least one fatty acid and / or its salt (component (C)).

[0148] For example, the composition (RC) used according to the present disclosure can be applied to at least a portion of the scalp area or to at least a portion of the skin area including facial hair once, twice, or even three times or more per day to deliver an effective amount of the active ingredient combination, i.e., a combination of santalol (component (A)), caffeine (component B)) and at least one fatty acid and / or a salt thereof (component (C)) per day.

[0149] For example, the active ingredient combination, i.e., a combination of santalol (component (A)), caffeine (component B)) and at least one fatty acid and / or a salt thereof (component (C)), can be applied once or twice a day (24 hours) to at least a portion of the scalp area or to at least a portion of the skin area including facial hair.

[0150] In case the composition (RC) is a shampoo, it has been found to be sufficient to apply the composition (RC) once a day (24 hours).

[0151] The composition (RC) used according to the present disclosure is preferably applied topically to at least a portion of the scalp area, or to at least a portion of the skin area including facial hair, for at least 1 minute, preferably at least 1.5 minutes and more preferably at least 2 minutes to obtain the desired effects (i and ii).

[0152] In particular, it is preferred to remove the composition (RC) by applying water to the hair and scalp after use.

[0153] Another subject of the present disclosure is the use of a composition (RC) for improving hair structure (i) and reducing hair loss (ii). For example, the present invention contemplates the use of a composition (RC) for improving hair structure (i), wherein the improving hair structure comprises increasing the cross-section of the hair. Furthermore, the present invention contemplates the use of a composition (RC) for improving hair structure (i) and reducing hair loss (ii), wherein the improving hair structure comprises increasing the expression of keratin, in particular the expression of keratin 85. Furthermore, the present invention contemplates the use of a composition (RC) according to the present disclosure for improving the structure of hair affected by age-related hair thinning (i).

[0154] The following examples shall illustrate the invention in more detail, but the details of these examples shall not be construed as limiting the claims.

[0155] Implementation

[0156] 1. Cosmetic use of a topically applicable rinse-off composition (RC) comprising as a component

[0157] (A) santalpentyl alcohol ((3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more santalpentyl alcohol analogs,

[0158] (B) Caffeine,

[0159] (C) at least one C10-C18 fatty acid and / or a salt thereof,

[0160] (D) at least one surfactant, and

[0161] (E) at least one cosmetically acceptable solvent,

[0162] Its use

[0163] (i) improve hair structure, and

[0164] (ii) Reduce hair loss.

[0165] 2. The cosmetic use according to embodiment 1, wherein the topically administrable rinse-off composition (RC) comprises

[0166] 0.010 to 10% by weight of component (A),

[0167] 0.010 to 10% by weight of component (B),

[0168] 0.010 to 5% by weight of component (C),

[0169] 5.0 to 30% by weight of component (D), and

[0170] 45 to 94.97 wt. % of component (E),

[0171] The weight % values ​​are based on the total weight of the topically administrable rinse-off composition (RC).

[0172] 3. The cosmetic use according to embodiment 1 or 2, wherein improving the hair structure (i) comprises increasing the cross-section of the hair.

[0173] 4. The cosmetic use according to any one of embodiments 1 to 3, wherein improving the hair structure (i) comprises increasing the expression of keratin.

[0174] 5. The cosmetic use according to any one of embodiments 1 to 4, wherein improving the hair structure (i) comprises increasing the expression of keratin 85.

[0175] 6. The cosmetic use according to any one of embodiments 1 to 5, wherein the reduction of hair loss (ii) is the reduction of androgenic alopecia.

[0176] 7. The cosmetic use according to any one of embodiments 1 to 6, wherein the weight ratio of component (A) to component (B) is in the range of 1:2 to 2:1, more specifically in the range of 1:1.5 to 1.5:1, and especially in the range of 1:1.2 to 1.2:1.

[0177] 8. The cosmetic use according to any one of embodiments 1 to 7, wherein component (D) is at least one detergent surfactant selected from the group consisting of anionic detergent surfactants, cationic detergent surfactants and nonionic detergent surfactants, excluding fatty acid surfactants.

[0178] 9. The cosmetic use according to any one of embodiments 1 to 8, wherein the one or more santalpentyl alcohol analogs that can be included in component (A) are at least one santalpentyl alcohol analog selected from the group consisting of: santalpentenol ((4Z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), santacyclopropane (1-methyl-2-((1,2.2-trimethylbicyclo(3.1.0)hex-3-yl)methyl)-cyclopropane-methanol), santalpentenol ((4Z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), ((E)-3,3-dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), santaline (2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)butanol), santaline ((E)-2-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol) and santaline butenol ((E)-2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol).

[0179] 10. The cosmetic use according to any one of embodiments 1 to 9, wherein improving the hair structure (i) comprises improving the structure of hair affected by age-related hair thinning.

[0180] 11. The cosmetic use according to any one of embodiments 1 to 10, wherein component (C) comprises at least 50% by weight of lauric acid and / or a salt thereof, based on the total amount of component (C) contained in the topically administrable rinse-off composition (RC).

[0181] 12. The cosmetic use according to any one of embodiments 1 to 11, wherein component (A) comprises at least 50% by weight of santalpentyl alcohol, based on the total amount of component (A) contained in the topically administrable rinse-off composition (RC).

[0182] 13. The cosmetic use according to any one of embodiments 1 to 12, wherein component (E) is at least one cosmetically acceptable solvent selected from the group consisting of water, ethanol, propanol, glycerol, ethylene glycol and propylene glycol.

[0183] 14. The cosmetic use according to any one of embodiments 1 to 13, wherein the topically administrable rinse-off composition (RC) is at least one composition selected from the group consisting of a hair lotion, a hair conditioner, a hair cream, a shampoo, a dry shampoo, a hair foam and a shampoo bar.

[0184] 15. A non-therapeutic method for (i) improving hair structure and (ii) reducing hair loss, the method comprising the steps of:

[0185] a) Rinse the hair and scalp with water,

[0186] b) topically applying a rinse-off composition (RC) according to any one of embodiments 1 to 14 to the hair and scalp for a period of at least 1 minute, preferably at least 2 minutes,

[0187] c) rinsing the hair and scalp with water to remove the rinse-off composition (RC) according to any one of embodiments 1 to 14 from the hair and scalp,

[0188] Wherein steps a), b) and c) are performed at least once within a period of 48 hours, preferably at least once within a period of 24 hours.

[0189] Example

[0190] Clinical research results

[0191] Research Methods

[0192] In a single-center randomized clinical study, the hair condition of the test subjects was Evaluation: The hair was cut into pieces at about 2 cm with the help of scissors. 2 The hair was trimmed in a small area of ​​. The designated area located on the lateral parietal region was trimmed and the template was placed on the area to enable precise hair trimming. For one subject, the test area was the same throughout the study. After 3 days, the hair was dyed and a video image magnified 20 times was stored. The image was taken at 0.903 cm 2 The image is taken in the area (measurement area). The measurements provide data on: hair thickness; telogen rate; anagen rate; number of hairs in anagen and telogen phases and anagen / telogen ratio.

[0193] Anagen rate was measured initially (T0) and after 12 weeks (T3M), 24 weeks (T6M), 36 weeks (T9M), and 48 weeks (T12M).

[0194] Hair thickness was measured initially (T0) and after 48 weeks (T12M).

[0195] Study participants

[0196] For anagen rate, the number of subjects included in each leg was 33. All included subjects had a telogen rate greater than 20% at the start of the study. The number of subjects who completed the study after 48 weeks was 30, with 50% females and 50% males (35 to 65 years old) in each leg.

[0197] For hair thickness, the number of subjects included in each group was 30. All included subjects had a telogen rate of hair growth higher than 20% at the beginning of the study. The number of subjects who completed the study after 48 weeks was 30, with 50% females and 50% males (35 to 65 years old) in each group.

[0198] Study Setting

[0199] Participants selected for the study used the product by applying it to the hair and scalp at home once a day, massaging for 2 minutes, for 48 weeks.

[0200] The following shows the recipe of the product used:

[0201]

[0202]

[0203] Evaluation Criteria

[0204] At the above time points, experts Measurements. Both anagen rate (% of hair in anagen) and hair thickness were analyzed.

[0205] Anagen is the active growth phase of the hair follicle. During anagen, cells in the hair root divide rapidly, adding to the hair shaft. An increase in the anagen rate indicates a decrease in hair loss because more hair is in the growth phase.

[0206] result

[0207] Before-after comparisons of hair thickness and anagen rate compared to the initial ("T0") anagen rate were statistically significant at all time points.

[0208] Hair thickness did increase, although the mean values ​​measured after 48 weeks of product use (T12M) were statistically significantly higher compared to the initial ("T0") hair thickness:

[0209] Anagen rate

[0210] time n Mean score ± SD Percent change relative to T0 P-Value* T0 33 69.92±12.22 - - T3M 33 72.55±12.22 2.63 0.0036 T6M 33 74.96±12.19 5.04 0.0001 T9M 30 79.10±10.93 9.11 <0.0001 T12M 30 81.90±11.19 11.91 <0.0001

[0211] *: If p < 0.05, the difference is statistically significant compared to T0

[0212] Hair thickness / mm

[0213] time n Mean score ± SD Percent change relative to T0 P-Value* T0 30 0.058±0.01 - - T12M 30 0.063±0.009 8.6 0.0003

[0214] *: If p < 0.05, there is a statistically significant difference relative to T0.

Claims

1. Cosmetic use of a topically applicable rinse-off composition (RC) comprising as a component (A) santalpentyl alcohol ((3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more santalpentyl alcohol analogs, (B) Caffeine, (C) at least one C10-C18 fatty acid and / or a salt thereof, (D) at least one surfactant, and (E) at least one cosmetically acceptable solvent, Its use (i) improve hair structure, and (ii) Reduce hair loss.

2. The cosmetic use according to claim 1, wherein the topically administrable rinse-off composition (RC) comprises 0.010 to 10% by weight of component (A), 0.010 to 10% by weight of component (B), 0.010 to 5% by weight of component (C), 5.0 to 30% by weight of component (D), and 45 to 94.97 wt. % of component (E), The weight % values ​​are based on the total weight of the topically administrable rinse-off composition (RC).

3. The cosmetic use according to claim 1 or 2, wherein improving the hair structure (i) comprises increasing the cross-section of the hair.

4. The cosmetic use according to any one of claims 1 to 3, wherein improving the hair structure (i) comprises increasing the expression of keratin.

5. The cosmetic use according to any one of claims 1 to 4, wherein improving the hair structure (i) comprises increasing the expression of keratin 85.

6. The cosmetic use according to any one of claims 1 to 5, wherein the reduction of hair loss (ii) is the reduction of androgenic alopecia.

7. The cosmetic use according to any one of claims 1 to 6, wherein the weight ratio of component (A) to component (B) is in the range of 1:2 to 2:1, more specifically in the range of 1:1.5 to 1.5:1, and especially in the range of 1:1.2 to 1.2:

1.

8. The cosmetic use according to any one of claims 1 to 7, wherein component (D) is at least one detergent surfactant selected from the group consisting of anionic detergent surfactants, cationic detergent surfactants and nonionic detergent surfactants, excluding fatty acid surfactants.

9. The cosmetic use according to any one of claims 1 to 8, wherein the one or more santalpentyl alcohol analogs that can be included in component (A) are at least one santalpentyl alcohol analog selected from the group consisting of santalpentenol ((4Z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), santacyclopropane (1-methyl-2-((1,2.2-trimethylbicyclo(3.1.0)hex-3-yl)methyl)-cyclopropane-methanol), santalpentenol ((4Z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), ((E)-3,3-dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), santaline (2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)butanol), santaline ((E)-2-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol) and santaline butenol ((E)-2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol).

10. The cosmetic use according to any one of claims 1 to 9, wherein improving the hair structure (i) comprises improving the structure of hair affected by age-related hair thinning.

11. The cosmetic use according to any one of claims 1 to 10, wherein component (C) comprises at least 50% by weight of lauric acid and / or a salt thereof, based on the total amount of component (C) contained in the topically applicable rinse-off composition (RC).

12. The cosmetic use according to any one of claims 1 to 11, wherein component (A) comprises at least 50% by weight of santalpentyl alcohol, based on the total amount of component (A) contained in the topically applicable rinse-off composition (RC).

13. The cosmetic use according to any one of claims 1 to 12, wherein component (E) is at least one cosmetically acceptable solvent selected from the group consisting of water, ethanol, propanol, glycerol, ethylene glycol and propylene glycol.

14. The cosmetic use according to any one of claims 1 to 13, wherein the topically administrable rinse-off composition (RC) is at least one composition selected from the group consisting of a hair lotion, a hair conditioner, a hair cream, a shampoo, a dry shampoo, a hair foam and a shampoo bar.

15. A non-therapeutic method for (i) improving hair structure and (ii) reducing hair loss, the method comprising the steps of: a) Rinse the hair and scalp with water, b) applying topically to the hair and scalp a rinse-off composition (RC) as claimed in any one of claims 1 to 14 for a period of at least 1 minute, preferably at least 2 minutes, c) rinsing the hair and scalp with water to remove the rinse-off composition (RC) according to any one of claims 1 to 14 from the hair and scalp, Wherein steps a), b) and c) are performed at least once within a period of 48 hours, preferably at least once within a period of 24 hours.

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