Composition for tonifying spleen and invigorating stomach as well as preparation method and application thereof

Abstract

The invention relates to the technical field of biological medicines, and provides a composition for tonifying spleen and invigorating stomach as well as a preparation method and application thereof. The composition for tonifying the spleen and invigorating the stomach is prepared from the following raw materials: erythritol, barley green, a cordyceps militaris extract, a broccoli extract, mannitol, maltodextrin, magnesium stearate and citric acid. According to the composition for tonifying the spleen and invigorating the stomach, the barley green, the cordyceps militaris extract and the broccoli extract in a specific ratio are adopted in the formula, so that the composition has the effects of tonifying the spleen and invigorating the stomach, and can be used for improving the symptoms such as weakness of the spleen and the stomach and undisappearing of diet.

Description

Technical Field

[0001] The present invention relates to the field of biomedicine technology, and in particular to a composition for invigorating the spleen and strengthening the stomach. The present invention also relates to a preparation method and application of the composition for invigorating the spleen and strengthening the stomach. Background Art

[0002] Spleen deficiency is a common clinical syndrome, which is mostly caused by overwork, excessive rest, improper diet, excessive thinking, and humid living environment. It is a syndrome characterized by the decline of the physiological function of the spleen and the dysfunction of water and grain transportation. There are many chemical drugs on the market for treating the symptoms of spleen deficiency, but these drugs often have many adverse reactions and are difficult to meet the needs of the majority of patients. However, in traditional Chinese medicine, many Chinese medicines have the effects of lowering adverse reactions and stopping vomiting, eliminating lumps and removing fullness, soothing the liver and promoting gallbladder, and regulating the spleen and stomach, and can treat spleen deficiency without side effects or with very little side effects. For this reason, it is of great significance to develop a product that can improve the symptoms of spleen and stomach weakness, indigestion, and almost no side effects. Summary of the invention

[0003] In view of this, the present invention aims to provide a composition for tonifying the spleen and strengthening the stomach, which has the effect of tonifying the spleen and strengthening the stomach.

[0004] To achieve the above object, the technical solution of the present invention is achieved as follows:

[0005] A composition for invigorating the spleen and strengthening the stomach, wherein the raw materials of the composition for invigorating the spleen and strengthening the stomach include chlorophyll, cordyceps militaris extract, broccoli extract and auxiliary materials.

[0006] Furthermore, the raw materials of the auxiliary material include erythritol, mannitol, maltodextrin, magnesium stearate and citric acid.

[0007] Furthermore, the raw materials of the composition for tonifying the spleen and strengthening the stomach are, by weight percentage, 30%-40% erythritol, 15%-25% chlorophyll, 15%-25% Cordyceps militaris extract, 10%-20% broccoli extract, 10%-20% mannitol, 7%-15% maltodextrin, 0.1%-1% magnesium stearate, and 0.1%-1% citric acid.

[0008] Chlorophyll has the effects of anti-oxidation, enhancing immunity, regulating metabolism, promoting digestion, assisting in reducing fat and improving sleep. Cordyceps militaris extract has the effects of enhancing immunity, anti-fatigue, anti-oxidation, regulating blood lipids, protecting the liver and kidneys, improving sleep, anti-tumor, and nourishing the lungs and kidneys. At the same time, broccoli extract has the effects of supplementing nutrition, nourishing the stomach, nourishing kidney essence, anti-oxidation, lowering blood sugar and blood lipids, preventing cancer, etc., enhancing the liver's detoxification ability, improving the body's immunity, and beautifying and nourishing the skin.

[0009] To this end, the composition for tonifying the spleen and strengthening the stomach of the present invention is based on the combined use of chlorophyll, Cordyceps militaris extract and broccoli extract, which can be rich in dietary fiber, beneficial to nourishing the stomach, and combined with the anti-inflammatory and digestion-promoting functions of chlorophyll, it also helps gastrointestinal digestion and absorption. At the same time, it works synergistically with the Cordyceps militaris extract, has the effect of tonifying the spleen and strengthening the stomach, can be used to improve symptoms such as spleen and stomach weakness, indigestion, etc., and has no side effects, thereby better meeting the needs of patients.

[0010] In addition, the present invention also provides a method for preparing the composition for invigorating the spleen and strengthening the stomach as described above, comprising:

[0011] Weighing: weigh erythritol, chlorophyll, Cordyceps militaris extract, broccoli extract, mannitol, maltodextrin, magnesium stearate, and citric acid according to the preset weight percentage;

[0012] Granulation: preparing a wet soft material with the weighed erythritol, the chlorophyll, the Cordyceps militaris extract, the broccoli extract, the mannitol, the maltodextrin, and the citric acid to obtain uniform wet granules;

[0013] Granulation: drying the wet granules obtained by granulation to obtain prefabricated materials;

[0014] Total mixing: mixing the granulated preformed material and the magnesium stearate to obtain an intermediate;

[0015] Tableting: pressing the intermediate into tablets;

[0016] Inner packaging: Put the compressed tablets into bottles.

[0017] Furthermore, the binder used to prepare the wet granules is ethanol with a concentration of 70%-90%.

[0018] Furthermore, the moisture content of the prefabricated material is controlled below 5.0%.

[0019] Furthermore, the tablet weight of the compressed tablet is 0.6 g / tablet.

[0020] Furthermore, during the process of pressing the intermediate into the tablets, the difference in the filling amount during the pressing process is regularly checked.

[0021] Furthermore, the limit of the difference in the filling amount during the pressing process is required to be ±5%.

[0022] The preparation method of the composition for invigorating the spleen and strengthening the stomach described in the present invention mainly uses wet granulation tableting technology, which can increase the compressibility and fluidity of the composition during tableting, reduce or eliminate the phenomenon of loose tablets and cracked tablets, so as to have a higher tablet output rate, and can increase the dissolution rate of the drug and improve the bioavailability of the drug, thereby achieving the purpose of reducing costs and ensuring the quality of tableting.

[0023] In addition, the present invention also provides the use of the above-mentioned composition for invigorating the spleen and stomach in invigorating spleen and stomach medicines, health products or foods. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The accompanying drawings constituting a part of the present invention are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0025] Figure 1 The present invention is a flowchart of a method for preparing a composition for invigorating the spleen and strengthening the stomach according to an embodiment of the present invention. DETAILED DESCRIPTION

[0026] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0027] The present invention will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0028] This embodiment relates to a composition for tonifying the spleen and strengthening the stomach, which can improve symptoms such as spleen and stomach weakness and indigestion, and is a product with almost no side effects, thereby better meeting the needs of patients.

[0029] In terms of overall design, the composition for invigorating the spleen and stomach in this embodiment comprises chlorophyll, Cordyceps militaris extract, broccoli extract and auxiliary materials. As a preferred implementation form, the auxiliary materials comprise erythritol, mannitol, maltodextrin, magnesium stearate and citric acid.

[0030] The main components of chlorophyll include superoxide dismutase (SOD), flavonoids, amino acids, active enzymes, and a variety of minerals and vitamins. Among them, superoxide dismutase (SOD), as a powerful antioxidant, can effectively remove free radicals in the body, play an anti-oxidation and anti-aging role. Flavonoids and active enzymes help to reduce the body's inflammatory response and regulate the body's lipid metabolism, sugar metabolism, etc. Rich nutrients such as amino acids, minerals and vitamins can enhance human immunity and improve physical fitness. In addition, chlorophyll also helps maintain acid-base balance, provide essential nutrients, anti-bacterial and anti-inflammatory, promote red blood cell production, and relieve symptoms of iron deficiency anemia.

[0031] The main component of Cordyceps militaris extract is cordycepin, which is a natural antibiotic and the first nucleoside antibiotic isolated from fungi. It has multiple biological activities such as anti-fatigue, anti-virus, and immunity enhancement. It can effectively regulate the function of the immune system, replenish the essence of the human body, and promote the long-term travel of qi and blood. The main components of broccoli extract include protein, fat, carbohydrates, dietary fiber, vitamins (such as vitamin A, C, E), carotene, and various minerals (such as calcium, phosphorus, iron, zinc, etc.), which have the effects of supplementing nutrition, nourishing the stomach, replenishing kidney essence, anti-oxidation, and anti-cancer. In addition, it also contains pharmacological ingredients such as isothiocyanates, flavonoids and volatile oils, which not only have the function of regulating and preventing hypertension and heart disease, but also can enhance the liver's detoxification ability and improve the body's immunity.

[0032] The main component of erythritol is a naturally occurring four-carbon sugar alcohol, which not only has multiple functions such as anti-oxidation, increasing appetite and improving food flavor, reducing swelling and promoting blood circulation, protecting the oral cavity, but also has the functions of promoting digestion, improving skin condition (such as moisturizing), anti-inflammatory, promoting wound healing, and delaying skin aging. Mannitol is a powerful moisturizer that can attract and lock water molecules, help the skin retain moisture, prevent water evaporation, and thus maintain the moisture of the skin. At the same time, mannitol has the functions of anti-oxidation, anti-inflammatory, and enhancing the overall efficacy of the product.

[0033] Magnesium stearate has the effects of moisturizing, anti-oxidation, and inhibiting bacterial growth, and the main function of magnesium stearate is to assist in the preparation of the composition or tableting. For example, during the preparation of the composition, magnesium stearate has good anti-adhesive properties, which can prevent tablets or capsules from adhering to the equipment during the production process, thereby improving production efficiency. As a glidant, magnesium stearate can improve the fluidity of the powder and ensure the uniform distribution of the drug ingredients in the capsule or tablet. At the same time, in pharmaceutical preparations, magnesium stearate is mainly used as a lubricant, which can reduce the friction of the tablets during the pressing process, making the tablet molding smoother. Magnesium stearate has a certain hydrophobicity, which can slow down the dissolution rate of the drug in the gastrointestinal tract, thereby achieving a sustained-release effect, which helps to improve the stability and efficacy of the drug.

[0034] The main components of maltodextrin are glucose, maltose and other oligosaccharides, which have the functions of providing energy, promoting metabolism, moisturizing the intestines and laxatives, maintaining the balance of intestinal microecology, improving digestive function, preventing constipation and diarrhea, and promoting intestinal health. At the same time, maltodextrin can also increase the viscosity and solubility of food, making the food taste better. The main component of citric acid is a natural organic acid contained in fruits such as lemons, citrus, and pineapples. It has the functions of preservation and seasoning, freshness enhancement, improvement of indigestion, anti-oxidation, enhancement of human immunity, and help improve the stability and absorption rate of drugs.

[0035] In specific implementation, the raw materials of the composition for tonifying the spleen and strengthening the stomach are calculated by weight percentage: 30%-40% erythritol, 15%-25% chlorophyll, 15%-25% Cordyceps militaris extract, 10%-20% broccoli extract, 10%-20% mannitol, 7%-15% maltodextrin, 0.1%-1% magnesium stearate, and 0.1%-1% citric acid.

[0036] The composition for invigorating the spleen and strengthening the stomach of the present invention includes the above-mentioned raw materials, so that the raw materials can have a mutual promotion and synergistic effect, and have the effect of "1+1>2", especially through the specific ratio of chlorophyll, Cordyceps militaris extract and broccoli extract, so that the composition has the effect of invigorating the spleen and strengthening the stomach, and can be used to improve symptoms such as weak spleen and stomach and indigestion. Among them, broccoli extract is rich in dietary fiber, which is beneficial to nourish the stomach. Combined with the anti-inflammatory and digestion-promoting functions of chlorophyll, it is helpful for gastrointestinal digestion and absorption. At the same time, the synergistic effect of broccoli extract, chlorophyll and Cordyceps militaris extract not only has a good effect of invigorating the spleen and strengthening the stomach, but also has no side effects, and can better meet the needs of patients.

[0037] In addition, this embodiment also provides a method for preparing a composition for invigorating the spleen and stomach, such as Figure 1 As shown, including:

[0038] S1. Weighing: weigh erythritol, chlorophyll, Cordyceps militaris extract, broccoli extract, mannitol, maltodextrin, magnesium stearate, and citric acid according to preset weight percentages;

[0039] S2, granulation: the weighed erythritol, chlorophyll, Cordyceps militaris extract, broccoli extract, mannitol, maltodextrin, and citric acid are made into a wet soft material to obtain uniform wet granules;

[0040] S3, granulation: drying the wet granules obtained by granulation to obtain prefabricated materials;

[0041] S4, total mixing: mixing the granulated preformed material and magnesium stearate to obtain an intermediate;

[0042] S5, tableting: pressing the intermediate into tablets, and regularly checking the difference in loading during the pressing process;

[0043] S6, inner packaging: put the compressed tablets into bottles.

[0044] The binder used to prepare the wet granules is ethanol with a concentration of 70%-90%, and for example, it can be 80%. Here, 80% ethanol is used as the binder of the wet granules to prepare the wet soft material and granulate. Because the volatility of ethanol is moderate, it can effectively bind the raw materials to form wet granules with regular shapes and uniform sizes during the granulation process, which is convenient for subsequent processing, and can be quickly volatilized in the subsequent drying step, without excessive impurities remaining to affect the purity and quality of the product. Moreover, during granulation, the raw materials are fully mixed under the action of the binder, which further ensures that the ingredients are evenly distributed in each particle, avoiding the problem of unstable product efficacy or inconsistent taste caused by local ingredient concentration differences.

[0045] Furthermore, as a preferred embodiment, the moisture content of the prefabricated material is controlled below 5.0%. In this way, the product can be effectively prevented from becoming moldy, agglomerated, or deteriorating, ensuring the stability of the product during storage and transportation and extending the shelf life of the product. At the same time, precise moisture control also helps maintain the taste of the product and the activity of each component, ensuring that the product can achieve the best effect when used.

[0046] At the same time, as a preferred implementation form, the intermediate of this embodiment is compressed by a tablet press to form a compressed tablet, and the tablet weight is 0.6g / tablet. This arrangement will make the content of each raw material of the compressed tablet moderate, which is conducive to the subsequent use of the patient according to different dosage requirements. In addition, the loading difference limit requirement of the tablet press during the compression process is ±5% to ensure that the composition and content of each compressed tablet are moderate. Of course, the loading difference limit requirement is the weight difference limit requirement of the intermediate filled by the tablet press each time. Of course, the above-mentioned bottled compressed tablets should be qualified compressed tablets.

[0047] The preparation method of the composition for tonifying the spleen and strengthening the stomach in this embodiment is mainly based on wet granulation tableting technology, which can increase the compressibility and fluidity of the composition during tableting, reduce or eliminate the phenomenon of loose tablets and cracked tablets, so as to have a higher tablet output rate, and can increase the dissolution rate of the drug and improve the bioavailability of the drug, thereby achieving the purpose of reducing costs and ensuring the quality of tableting.

[0048] Here, the present invention is further described in conjunction with specific embodiments:

[0049] Example 1

[0050] A composition for invigorating the spleen and strengthening the stomach, wherein the raw materials are respectively as follows by weight percentage: 40% erythritol, 15% chlorophyll, 15% cordyceps militaris extract, 10% broccoli extract, 10% mannitol, 9% maltodextrin, 0.5% magnesium stearate and 0.5% citric acid.

[0051] The preparation method of the above-mentioned composition for invigorating the spleen and strengthening the stomach comprises:

[0052] S1. Weighing: weigh erythritol, chlorophyll, Cordyceps militaris extract, broccoli extract, mannitol, maltodextrin, magnesium stearate, and citric acid according to the above weight percentages;

[0053] S2. Granulation: Weighed erythritol, chlorophyll, Cordyceps militaris extract, broccoli extract, mannitol, maltodextrin, and citric acid are made into a wet soft material, and 80% ethanol is used as a binder for the wet granules to obtain uniform wet granules;

[0054] S3, granulation: placing the wet granules obtained by granulation into a hot air circulation oven for drying, and controlling the moisture content to no more than 5.0%, to obtain a prefabricated material;

[0055] S4, total mixing: mixing the granulated preformed material and magnesium stearate to obtain an intermediate;

[0056] S5, tableting: The intermediate is compressed into tablets with a tablet press having a tablet weight of 0.6 g / tablet, and the loading difference of the tablet press is regularly checked during the compression process, and the loading difference limit is required to be controlled to ±5%;

[0057] S6, inner packaging: put qualified tablets into bottles.

[0058] Example 2

[0059] A composition for invigorating the spleen and strengthening the stomach, wherein the raw materials are respectively as follows by weight percentage: 35% erythritol, 15% chlorophyll, 15% cordyceps militaris extract, 13% broccoli extract, 12% mannitol, 9% maltodextrin, 0.5% magnesium stearate and 0.5% citric acid.

[0060] The preparation method of the composition for invigorating the spleen and strengthening the stomach in this embodiment is the same as that in Example 1.

[0061] Example 3

[0062] A composition for invigorating the spleen and strengthening the stomach, wherein the raw materials are respectively as follows by weight percentage: 30% erythritol, 20% chlorophyll, 20% cordyceps militaris extract, 10% broccoli extract, 10% mannitol, 9% maltodextrin, 0.5% magnesium stearate and 0.5% citric acid.

[0063] The preparation method of the composition for invigorating the spleen and strengthening the stomach in this embodiment is the same as that in Example 1.

[0064] Example 4

[0065] A composition for invigorating the spleen and strengthening the stomach, wherein the raw materials are respectively as follows by weight percentage: 40% erythritol, 10% chlorophyll, 15% cordyceps militaris extract, 15% broccoli extract, 10% mannitol, 9% maltodextrin, 0.5% magnesium stearate and 0.5% citric acid.

[0066] The preparation method of the composition for invigorating the spleen and strengthening the stomach in this embodiment is the same as that in Example 1.

[0067] Example 5

[0068] A composition for invigorating the spleen and strengthening the stomach, wherein the raw materials are respectively as follows by weight percentage: 31% erythritol, 18% chlorophyll, 20% cordyceps militaris extract, 10% broccoli extract, 10% mannitol, 10% maltodextrin, 0.5% magnesium stearate and 0.5% citric acid.

[0069] The preparation method of the composition for invigorating the spleen and strengthening the stomach in this embodiment is the same as that in Example 1.

[0070] Evaluation of the ability of the composition for invigorating the spleen and stomach to assist gastrointestinal digestion and absorption:

[0071] In this example, the digestion and absorption capacity were evaluated by measuring the gastric emptying rate and the D-xylose excretion rate, and the improvement was visually evaluated through the changes.

[0072] Modeling and administration: 90 rats were randomly divided into a control group (i.e., a blank group), a model group, a mosapride group, and a low-dose group, a medium-dose group, and a high-dose group of the composition, with 15 rats in each group. Except for the control group, the 15 rats in the remaining groups were subcutaneously injected with reserpine injection in the neck every day, and the 15 rats in the control group were subcutaneously injected with an equal amount of normal saline in the neck every day for 14 consecutive days. The above composition is the composition for tonifying the spleen and strengthening the stomach in Example 1.

[0073] Then, the rats in the low-dose group, the medium-dose group and the high-dose group were gavaged daily with the drug (the composition for invigorating the spleen and strengthening the stomach in Example 1) for 14 consecutive days. The control group and the model group were gavaged with an equal volume of animal water, and the mosapride group was gavaged with an equal volume of mosapride solvent. The rats were fasted for about 12 hours before the last administration, and 2 hours after the last administration, each rat was gavaged with a semisolid paste. Among them, as a preferred embodiment, the dosage of the composition in the low-dose group, the medium-dose group and the high-dose group can be, for example, 0.45 g·kg -1 , 0.90g·kg -1 and 1.80 g kg -1 , and the administration is described by taking the low-dose group of the composition as an example. Specifically, the dosage s of each rat in the group and the weight (kg) m of the rat satisfy: s = m*0.45 g·kg -1 .

[0074] The gastric emptying rate of rats was calculated by the mass method, specifically:

[0075] 20 minutes after oral administration of the semisolid paste, the rats were anesthetized with 10% chloral hydrate solution, and then the abdominal cavity of the rats was opened and blood was collected from the abdominal aorta. At the same time, the gastric cardia and pylorus were ligated, and the stomach and small intestine were taken.

[0076] The mucosa on the surface of the stomach was removed, and the surface was dried with filter paper to measure the total mass of the stomach. Then the stomach body was cut open along the greater curvature of the stomach, the stomach contents were rinsed with saline and dried with filter paper to measure the net mass of the stomach. The difference between the total mass of the stomach and the net mass of the stomach was the mass of the residual in the stomach, and the gastric emptying rate was calculated. The calculation formula is: gastric emptying rate = 1-(total mass of the stomach-net mass of the stomach) / mass of solid paste. The results are shown in Table 1.

[0077] Table 1 Effects of different doses of the composition on gastric emptying function in spleen deficiency model rats

[0078]

[0079] The results are shown in Table 1. Compared with the control group, the gastric emptying rate of the model group rats decreased significantly. Compared with the model group, the gastric emptying rate of the positive drug mosapride group rats increased significantly, and the gastric emptying rate of the composition medium dose group and the composition high dose group rats also increased significantly.

[0080] In addition, experimental groups 1 to 5 were set up according to the above method. As mentioned above, 15 rats were allocated to each experimental group. The above-mentioned administration method was adopted. The rats in each experimental group were administered with the composition (high dose) of Examples 1 to 5 respectively. The results are shown in Table 2 below.

[0081] Table 2 Effects of the compositions of Examples 1 to 5 on gastric emptying function in spleen deficiency model rats

[0082]

[0083] The results are shown in Table 2. Due to the lower weight percentage of chlorophyll in experimental group 4, its gastric emptying rate was lower than that of experimental groups 1 to 3 and experimental group 5. A careful observation of experimental groups 1 to 3 and experimental group 5 showed that with the increase of the weight percentage of chlorophyll, Cordyceps militaris extract and broccoli extract, the gastric emptying rate of rats gradually increased.

[0084] The urinary D-xylose excretion rate of rats was detected by the sulfuric acid phenol method, specifically:

[0085] After the modeling and administration (i.e., as mentioned above: 90 rats were randomly divided into a control group, a model group, a mosapride group, and a low-dose group, a medium-dose group and a high-dose group of the composition, with 15 rats in each group. Except for the control group, the 15 rats in the other groups were subcutaneously injected with reserpine injection in the neck every day, and the 15 rats in the control group were subcutaneously injected with an equal amount of normal saline in the neck every day for 14 consecutive days. The above composition is the composition for tonifying the spleen and strengthening the stomach in Example 1. Then, the rats in the low-dose group, the medium-dose group and the high-dose group were subcutaneously injected with reserpine injection in the neck every day. Daily oral administration (composition for invigorating spleen and strengthening stomach in this embodiment 1) was continuously administered for 14 days. The control group and model group were respectively administered with equal volumes of animal water, and the mosapride group was administered with equal volumes of mosapride solvent. Fasting was performed for about 12 hours before the last administration. After 2 hours of the last administration, each rat was gavaged with semisolid paste. ), then the rats were fasted for 12 hours, and each rat was gavaged with D-xylose solution. After 14 days of the experiment, urine was collected for 5 hours (that is, all urine within 5 hours was collected), and after 28 days of the experiment, urine was collected for 3 hours (that is, all urine within 3 hours was collected). The calculation formula of urine D-xylose excretion rate is: urine D-xylose excretion rate (%) = (urine D-xylose concentration × urine volume × dilution multiple) / (gavage D-xylose volume × gavage D-xylose concentration) × 100%, and the results are shown in Table 3.

[0086] Table 3 Effect of the composition on urinary D-xylose excretion rate in spleen deficiency model rats

[0087]

[0088] The results are shown in Table 3. Compared with the control group, the urinary D-xylose excretion rate of the rats in the spleen deficiency model group was significantly reduced. Compared with the model group, the urinary D-xylose excretion rate of the rats in the positive drug mosapride group was significantly increased, and the D-xylose excretion rate of the rats in the medium dose group and the high dose group of the composition was also significantly increased.

[0089] In addition, experimental groups 1 to 5 were set up according to the grouping method for the above-mentioned urine D-xylose test, and 15 rats were allocated to each experimental group. The rats in each experimental group were administered with the composition (high dose) of Examples 1 to 5, respectively. After the administration, the rats in each group were gavaged with D-xylose solution and urine was collected using the above-mentioned experimental method. The results are shown in Table 4 below.

[0090] Table 4 Effect of the compositions of Examples 1 to 5 on urinary D-xylose excretion rate in spleen deficiency model rats

[0091]

[0092] The results are shown in Table 4. Due to the lower weight percentage of chlorophyll in experimental group 4, its urinary D-xylose excretion rate was lower than that of experimental groups 1 to 3 and experimental group 5. A careful observation of experimental groups 1 to 3 and experimental group 5 showed that with the increase of the weight percentage of chlorophyll, Cordyceps militaris extract and broccoli extract, the urinary D-xylose excretion rate of rats gradually increased.

[0093] Of course, for the various method parts not mentioned in the gastric emptying test and urinary D-xylose excretion test process of this embodiment, reference can be made to the relevant method parts in the gastric emptying test and urinary D-xylose excretion test well known to those skilled in the art, and no further description will be given here.

[0094] Therefore, the composition for invigorating the spleen and strengthening the stomach of the present embodiment has good invigorating the spleen and strengthening the stomach effect, and can be used to improve symptoms such as spleen and stomach weakness, indigestion, etc. In addition, the composition for invigorating the spleen and strengthening the stomach of the present embodiment can be used in invigorating the spleen and strengthening the stomach medicine, health care products or foods, especially made into health care products or foods, and the effect is better if consumed in moderation for a long time.

[0095] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A composition for invigorating the spleen and stomach, characterized in that: The raw materials of the composition for invigorating the spleen and stomach include chlorophyll, cordyceps militaris extract, broccoli extract and auxiliary materials.

2. The composition for invigorating the spleen and stomach according to claim 1, characterized in that: The raw materials of the auxiliary material include erythritol, mannitol, maltodextrin, magnesium stearate and citric acid.

3. The composition for invigorating the spleen and stomach according to claim 2, characterized in that: The raw materials of the composition for invigorating the spleen and strengthening the stomach are respectively as follows by weight percentage: Erythritol 30%-40%, chlorophyll 15%-25%, Cordyceps militaris extract 15%-25%, broccoli extract 10%-20%, mannitol 10%-20%, maltodextrin 7%-15%, magnesium stearate 0.1%-1%, citric acid 0.1%-1%.

4. A method for preparing the composition for invigorating the spleen and stomach according to claim 2 or 3, characterized in that: include: Weighing: weigh erythritol, chlorophyll, Cordyceps militaris extract, broccoli extract, mannitol, maltodextrin, magnesium stearate, and citric acid according to the preset weight percentage; Granulation: preparing a wet soft material with the weighed erythritol, the chlorophyll, the Cordyceps militaris extract, the broccoli extract, the mannitol, the maltodextrin, and the citric acid to obtain uniform wet granules; Granulation: drying the wet granules obtained by granulation to obtain prefabricated materials; Total mixing: mixing the granulated preformed material and the magnesium stearate to obtain an intermediate; Tableting: pressing the intermediate into tablets; Inner packaging: Put the compressed tablets into bottles.

5. The preparation method according to claim 4, characterized in that: The binder used to prepare the wet granules is ethanol at a concentration of 70%-90%.

6. The preparation method according to claim 4, characterized in that: The moisture content of the prefabricated material is controlled below 5.0%.

7. The preparation method according to claim 4, characterized in that: The tablet weight of the tablet is 0.6 g / tablet.

8. The preparation method according to claim 4, characterized in that: During the compression of the intermediate into the compressed tablets, the filling amount difference during the compression process is regularly checked.

9. The preparation method according to claim 8, characterized in that: The filling amount difference limit during the compression process is required to be ±5%.

10. Use of the composition for invigorating the spleen and stomach according to any one of claims 1 to 3 in invigorating the spleen and stomach medicines, health products or foods.

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