Preparation method of hirudo hypoglycemic capsule nanoparticles

Abstract

The invention relates to a preparation method of hirudo blood sugar-reducing capsule nanoparticles. The preparation method comprises the following steps: step 1, drying hirudo blood sugar-reducing capsule powder; step 2, adding the dried hirudo blood glucose reducing capsule powder into a grinding device for grinding to obtain nano powder; wherein the grinding equipment is an agate bead ball mill, the grinding equipment comprises a rack and a barrel used for containing agate grinding beads, and the barrel is rotationally erected on the rack; a plurality of guide pipes extending in the length direction are evenly laid on the outer wall of the cylinder body, the guide pipes are attached to the outer wall of the cylinder body, a water inlet pipe and a water outlet pipe extending towards the two ends are arranged at the centers of the two ends of the cylinder body respectively, and the cylinder body is rotationally connected with the rack through the water inlet pipe and the water outlet pipe. According to the technical scheme, the medicine can be fully ground, and meanwhile the stable medicine property of the medicine can be kept as much as possible.

Description

Technical Field

[0001] The invention relates to the technical field of drug preparation, and in particular to a method for preparing Danzhi Jiangtang Capsule nanoparticles. Background Art

[0002] Danzhi Jiangtang Capsule is an in-hospital preparation of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine (Anhui Medicine Manufacturing Code Z20090006), which consists of six medicinal herbs: Radix Pseudostellariae, Radix Rehmanniae, Cortex Moutan, Semen Cuscutae, Rhizoma Alismatis, and Hirudo. It is mainly used in the treatment of Qi deficiency, Yin deficiency, and blood stasis syndrome of type 2 diabetes and its chronic complications of vascular diseases, with significant efficacy. However, there are still some problems in which the powder formed by ordinary grinding and pulverization of traditional Chinese medicine is highly hydrophobic, has poor in vivo stability, and has low bioavailability, resulting in limited clinical application.

[0003] The combination of nanotechnology and traditional Chinese medicine can effectively solve these problems. That is, "nano-TCM" in nano-TCM technology refers to the processing of the effective ingredients, effective parts, original drugs and their compound preparations of TCM to nano-size based on nanotechnology, thereby improving the bioavailability of drugs and increasing drug targeting. Summary of the invention

[0004] In view of this, the purpose of the present invention is to provide a method for preparing Danzhi Jiangtang Capsule nanoparticles to solve the problems in the prior art that some traditional Chinese medicine powders formed by ordinary grinding and pulverization have strong hydrophobicity, poor in vivo stability, low bioavailability, and limited clinical application.

[0005] The present invention is achieved through the following technical solutions:

[0006] A method for preparing Danzhi Jiangtang Capsule nanoparticles comprises the following steps:

[0007] Step 1, drying the powder of Danzhijiangtang Capsule;

[0008] Step 2, adding the dried Danzhi Jiangtang Capsule powder into a grinding device for grinding to obtain nanometer powder;

[0009] Wherein, the grinding equipment is an agate bead ball mill, and the grinding equipment comprises a frame and a cylinder for accommodating agate grinding beads, and the cylinder is rotatably mounted on the frame;

[0010] The outer wall of the cylinder is evenly laid with a plurality of conduits extending in the length direction, and the conduits are in contact with the outer wall of the cylinder. The centers of both ends of the cylinder are respectively provided with water inlet pipes and water outlet pipes extending outwards from both ends, and are rotatably connected to the frame through the water inlet pipes and water outlet pipes;

[0011] The two ends of the plurality of conduits are respectively connected to the water inlet pipe and the water outlet pipe, and the outer wall of the water outlet conduit away from the cylinder is surrounded by a plurality of drainage pipes, one end of the plurality of drainage pipes is connected to the water outlet pipe, and the other end is inclined to the same side;

[0012] A protective cover covering the outer ends of the plurality of drainage pipes is fixedly mounted on the frame, and a discharge port is arranged at the bottom of the protective cover;

[0013] A water pump is also arranged on the frame, the inlet of the water pump is communicated with the discharge port, and the outlet of the water pump is communicated with an end of the water inlet pipe away from the cylinder.

[0014] It is further defined that the water inlet pipe is connected to a first seat plate at one end facing the cylinder, the first seat plate is detachably connected to the end of the cylinder, and the first seat plate is provided with a first conical water guide protruding into the water inlet pipe;

[0015] The end of the water outlet pipe facing the cylinder is connected with a second seat plate, the second seat plate is detachably connected to the end of the cylinder, and the second seat plate is provided with a second conical water guide portion protruding into the water outlet pipe.

[0016] It is further defined that a radiator is arranged between the drain outlet and the inlet of the water pump, and the radiator includes a shunt pipe, a confluence pipe and a plurality of heat dissipation pipes, the shunt pipe and the confluence pipe are arranged in parallel, and the plurality of heat dissipation pipes are arranged in parallel between the shunt pipe and the confluence pipe, and the two ends are respectively connected to the shunt pipe and the confluence pipe, and a gap for air circulation is arranged between any two adjacent heat dissipation pipes.

[0017] It is further defined that a rotating shaft is rotatably connected to the frame, one end of the rotating shaft is rotatably connected to the frame, and a plurality of blades are arranged outside the other end. The rotating shaft is arranged parallel to the water outlet pipe, and the rotating shaft and the water outlet pipe are transmission-connected.

[0018] It is further defined that the heat dissipation pipe is provided with a heat conduction fin extending toward a side away from the rotating shaft.

[0019] It is further defined that a sealing plate is provided at one end of the water inlet pipe away from the cylinder, a plurality of through holes are opened on the sealing plate, the plurality of through holes are evenly distributed with the center of the sealing plate as the center of a circle, the plurality of through holes are arc-shaped strip holes, and the inner diameter of the end of the plurality of through holes facing the rotation direction is smaller than the hole diameter of the end facing away from the rotation direction;

[0020] A hollow shell-shaped diverter cover is arranged outside the end of the water inlet pipe away from the cylinder body. The diverter cover is fixedly mounted on the frame and is connected to the outlet of the water pump through a pipeline. The diverter cover is a planar structure on the side facing the water inlet pipe, and a plurality of drainage holes corresponding to the plurality of through holes are opened on this side, and the aperture of the drainage hole is not less than the aperture of the larger end of the through hole.

[0021] It is further defined that a sleeve is connected to the diverter cover, and the sleeve is rotatably sleeved outside the water inlet pipe.

[0022] It is further defined that the cylinder is wrapped with a heat-conducting layer, a plurality of flow channels penetrating along the axial direction are opened in the heat-conducting layer, and the conduit is composed of the flow channels.

[0023] It is further defined that a liner is provided in the cylinder, and a spiral guide groove is provided on the inner wall of the liner;

[0024] There are two liner tubes, and the spiral directions of the guide grooves opened on two adjacent liner tubes are opposite.

[0025] It is further defined that a water storage tank is provided between the inlet of the water pump and the radiator.

[0026] The beneficial effects of the present invention are:

[0027] The method for preparing Danzhi hypoglycemic capsule nanoparticles uses a water pump as a power source, and multiple conduits are respectively connected to the outlet and the inlet of the water pump through a water inlet pipe and a water outlet pipe to form a loop. When the water pump is started, water can be pushed to flow in the loop. The heat transfer structure formed by the multiple conduits on the cylinder can transfer the heat generated by the cylinder during the grinding process to the water flowing inside, so that the cylinder is kept in a relatively low temperature state, and then the internal medicine is kept in a relatively low temperature state during the grinding process, so that the medicine can be fully ground and the medicinal properties of the medicine can be kept as stable as possible.

[0028] Other advantages, objectives and features of the present invention will be described in the following description to some extent, and to some extent, will be obvious to those skilled in the art based on the following examination and study, or can be taught from the practice of the present invention. The objectives and other advantages of the present invention can be realized and obtained through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The three-dimensional Figure 1 ;

[0030] Figure 2 The three-dimensional Figure 2 ;

[0031] Figure 3 It is a front view of the present invention;

[0032] Figure 4 It is a schematic diagram of the internal structure of the present invention;

[0033] Figure 5 It is a schematic diagram of the matching structure of the water inlet pipe and the splitter cover;

[0034] Figure 6 It is a structural diagram of the drainage pipe;

[0035] Figure 7 is a structural schematic diagram of a radiator;

[0036] In the figure: 1, frame; 2, cylinder; 3, conduit; 4, water inlet pipe; 5, water outlet pipe; 6, drain pipe; 7, protective cover; 8, discharge port; 9, water pump; 10, first seat plate; 11, first conical water guide part; 12, second seat plate; 13, second conical water guide part; 14, diverter pipe; 15, converging pipe; 16, heat dissipation pipe; 17, rotating shaft; 18, blade; 19, transmission belt; 20, heat conduction fin plate; 21, sealing plate; 22, through hole; 23, diverter cover; 24, heat conduction layer; 25, liner; 26, guide groove; 27, water storage tank; 28, drain hole; 29, casing. DETAILED DESCRIPTION

[0037] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0038] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0039] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0040] In the above description of the present invention, it should be noted that the terms "one side", "the other side", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the product of the invention is usually placed when in use, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0041] In addition, the term "same" does not mean that the parts must be absolutely the same, but slight differences are allowed. The term "vertical" only means that the positional relationship between the parts is more vertical than "parallel", and does not mean that the structure must be completely vertical, but can be slightly tilted.

[0042] See also Figure 1-7 The present invention provides a technical solution: a method for preparing Danzhi Jiangtang Capsule nanoparticles, comprising the following steps:

[0043] Step 1, drying the powder of Danzhijiangtang Capsule;

[0044] Step 2, adding the dried Danzhi Jiangtang Capsule powder into a grinding device for grinding to obtain nanometer powder;

[0045] The grinding device is an agate bead ball mill, which comprises a frame 1 and a cylinder 2 for accommodating agate grinding beads, wherein the cylinder 2 is rotatably mounted on the frame 1;

[0046] The outer wall of the cylinder 2 is evenly paved with a plurality of conduits 3 extending in the length direction, and the conduits 3 are in contact with the outer wall of the cylinder 2. The centers of both ends of the cylinder 2 are respectively provided with a water inlet pipe 4 and a water outlet pipe 5 extending outwards from both ends, and the cylinder 2 is rotatably connected to the frame 1 through the water inlet pipe 4 and the water outlet pipe 5;

[0047] The two ends of the plurality of conduits 3 are respectively connected to the water inlet pipe 4 and the water outlet pipe 5. The outer wall of the water outlet conduit 3 away from the cylinder 2 is surrounded by a plurality of drain pipes 6. One end of the plurality of drain pipes 6 is connected to the water outlet pipe 5, and the other end is inclined to the same side.

[0048] A protective cover 7 covering one end of a plurality of drainage pipes 6 is fixedly mounted on the frame 1, and a discharge port 8 is arranged at the bottom of the protective cover 7;

[0049] The frame 1 is also provided with a water pump 9 , the inlet of the water pump 9 is connected with the discharge port 8 , and the outlet is connected with the end of the water inlet pipe 4 away from the cylinder 2 .

[0050] The water pump 9 is used as a power source, and the plurality of conduits 3 are respectively connected to the outlet and the inlet of the water pump 9 through the water inlet pipe 4 and the water outlet pipe 5 to form a loop. When the water pump 9 is started, the water can be pushed to flow in the loop. The heat transfer structure formed by the plurality of conduits 3 on the cylinder 2 can transfer the heat generated by the cylinder 2 during the grinding process to the water flowing inside, so that the cylinder 2 is kept at a relatively low temperature state, and the internal medicine is kept at a relatively low temperature state during the grinding process, so that the medicine can be fully ground and the medicinal properties of the medicine can be kept as stable as possible;

[0051] Moreover, a plurality of drain pipes 6 are arranged on the water outlet pipe 5 as outlets for water injection, and the injection ends thereof are inclined to the same side. Then, during injection, the cylinder 2 is pushed to rotate on the frame 1 by the reaction force. The cylinder 2 rotates by relying on the reaction force of the water jet as the power, and its rotation speed can be regulated by the rotation speed of the water pump 9. By utilizing the work done by the water pump 9, energy is integrated and the utilization rate of energy is improved.

[0052] In this embodiment, the end of the water inlet pipe 4 facing the cylinder 2 is connected to a first seat plate 10, the first seat plate 10 is detachably connected to the end of the cylinder 2, and the first seat plate 10 is provided with a first conical water guide portion 11 protruding into the water inlet pipe 4;

[0053] The end of the water outlet pipe 5 facing the cylinder 2 is connected to a second seat plate 12 , the second seat plate 12 is detachably connected to the end of the cylinder 2 , and a second conical water guide portion 13 protruding into the water outlet pipe 5 is provided on the second seat plate 12 .

[0054] The top of the first conical water guide 11 faces the water flow. When the water flows in, it will diffuse around under the action of the first conical water guide 11 and enter multiple conduits 3. When the water flows into the outlet pipe 5, it will flush the side wall of the second conical water guide 13 and gather toward the top of the cone, both of which can guide the water flow and reduce the energy loss when the water flow changes direction.

[0055] In this embodiment, a radiator is arranged between the drain outlet and the inlet of the water pump 9, and the radiator includes a shunt pipe 14, a confluence pipe 15 and a plurality of heat dissipation pipes 16. The shunt pipe 14 and the confluence pipe 15 are arranged in parallel, and the plurality of heat dissipation pipes 16 are arranged in parallel between the shunt pipe 14 and the confluence pipe 15, and the two ends are respectively connected to the shunt pipe 14 and the confluence pipe 15, and a gap for air circulation is arranged between any two adjacent heat dissipation pipes 16.

[0056] By dividing the water flow through a plurality of heat dissipation pipes 16, the contact area with the outside world can be effectively increased, the heat exchange effect with the outside world is improved, and it is beneficial to dissipate the heat of the cylinder 2 to the outside world.

[0057] In this embodiment, a rotating shaft 17 is rotatably connected to the frame 1, one end of the rotating shaft 17 is rotatably connected to the frame 1, and a plurality of blades 18 are arranged on the other end. The rotating shaft 17 is arranged parallel to the water outlet pipe 5, and the rotating shaft 17 and the water outlet pipe 5 are transmission-connected.

[0058] The rotating shaft 17 and the water outlet pipe 5 can be connected by a transmission structure such as a transmission belt or gears. When the water outlet pipe 5 rotates with the cylinder 2, it will drive the rotating shaft 17 to rotate synchronously. When the rotating shaft 17 rotates, it will drive multiple blades 18 to rotate, forming a fan-like structure for promoting air flow, thereby improving the heat exchange effect between the air and the heat dissipation pipe 16.

[0059] In this embodiment, the heat dissipation pipe 16 is provided with a heat conducting fin plate 20 extending toward a side away from the rotating shaft 17 .

[0060] The heat-conducting fins 20 can increase the contact area between the heat dissipation pipe 16 and the outside world, further improving the heat exchange effect between the heat dissipation pipe 16 and the outside world. At the same time, the heat-conducting fins 20 have a guiding effect when in contact with the flowing air, reducing the turbulence formed during the air flow, that is, reducing the vibration of the flowing air on the heat dissipation pipe 16, and improving the structural stability.

[0061] In this embodiment, a sealing plate 21 is provided at one end of the water inlet pipe 4 away from the cylinder 2, and a plurality of through holes 22 are opened on the sealing plate 21. The plurality of through holes 22 are evenly distributed with the center of the sealing plate 21 as the center of the circle, and the plurality of through holes 22 are arc-shaped strip holes, and the inner diameter of the end of the plurality of through holes 22 facing the rotation direction is smaller than the hole diameter of the end facing away from the rotation direction;

[0062] A hollow shell-shaped diverter cover 23 is arranged outside the end of the water inlet pipe 4 away from the cylinder 2. The diverter cover 23 is fixedly mounted on the frame 1 and is connected to the outlet of the water pump 9 through a pipeline. The diverter cover 23 is a planar structure on the side facing the water inlet pipe 4, and a plurality of drainage holes 28 corresponding to the plurality of through holes 22 are opened on this side, and the aperture of the drainage hole 28 is not less than the aperture of the larger end of the through hole 22.

[0063] The sealing plate 21 is connected to the water inlet pipe 4, and rotates with the water inlet pipe 4. During the rotation, the through hole 22 and the drain hole 28 are displaced, so that the passage connecting the two changes periodically. When the connecting passage becomes larger, the internal water flow is large, and the amount of water discharged from the drain pipe 6 is large, and the reaction force formed is large. On the contrary, when the connecting passage becomes smaller, the internal water flow is small, and the amount of water discharged from the drain pipe 6 is small, and the reaction force formed is small.

[0064] The rotation of the cylinder 2 is driven by the reaction of water discharged from the drain pipe 6. When the power changes periodically, the rotation speed of the cylinder 2 will also change periodically, causing the movement speed of the agate grinding beads inside to fluctuate, thereby improving the grinding effect of the medicine.

[0065] In this embodiment, a sleeve 29 is connected to the diverter cover 23 , and the sleeve 29 is rotatably sleeved outside the water inlet pipe 4 .

[0066] The splitter cover 23 is wrapped around the end of the water inlet pipe 4 by the sleeve 29, which can improve the stability of the connection structure with the sleeve 29. At the same time, the sleeve 29 serves as an extension of the contact surface between the two, which can increase the contact area between the two and improve the sealing between the two.

[0067] In this embodiment, the cylinder 2 is wrapped with a heat-conducting layer 24 , a plurality of flow channels penetrating along the axial direction are provided in the heat-conducting layer 24 , and the conduit 3 is composed of the flow channels.

[0068] The heat-conducting layer 24 may be a tubular structure made of a metal material with good heat transfer effect such as copper, which can quickly dissipate the heat generated in the cylinder 2 due to grinding.

[0069] In this embodiment, a liner tube 25 is provided in the cylinder body 2, and a spiral guide groove 26 is provided on the inner wall of the liner tube 25; two liner tubes 25 are provided, and the spiral directions of the guide grooves 26 opened on two adjacent liner tubes 25 are opposite.

[0070] The liner 25 is fixed to the inner wall of the cylinder 2, and can be made of a high-hardness alloy such as stainless steel. It has a spiral guide groove 26 as a rolling guide structure for the internal agate grinding beads during rotation, so that the agate grinding beads can move toward one end of the cylinder 2 when the cylinder 2 rotates. The spiral directions of the guide grooves 26 provided on the two liner tubes 25 are opposite. When the two liner tubes 25 rotate in the same direction, the internal agate grinding beads will move inward synchronously, forming extrusion at the intersection of the two liner tubes 25, further improving the grinding effect of the medicine.

[0071] The inclination direction of the drainage pipe 6 is determined according to the spiral direction of the guide grooves 26 in the two lining pipes 25 .

[0072] In this embodiment, a water storage tank 27 is provided between the inlet of the water pump 9 and the radiator.

[0073] The water storage tank 27 is used to contain water, and the ratio of its content to the water flow loop capacity is not less than 3, providing sufficient water source for the water pump 9 to avoid idling due to lack of water before the water pump 9 starts the water flow to form a closed loop flow.

[0074] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the purpose and scope of the technical solution of the present invention, which should be included in the scope of the claims of the present invention.

Claims

1. A method for preparing Danzhi Jiangtang Capsule nanoparticles, characterized in that: The steps include: Step 1, drying the powder of Danzhijiangtang Capsule; Step 2, adding the dried Danzhi Jiangtang Capsule powder into a grinding device for grinding to obtain nanometer powder; Wherein, the grinding equipment is an agate bead ball mill, and the grinding equipment comprises a frame and a cylinder for accommodating agate grinding beads, and the cylinder is rotatably mounted on the frame; The outer wall of the cylinder is evenly laid with a plurality of conduits extending in the length direction, and the conduits are in contact with the outer wall of the cylinder. The centers of both ends of the cylinder are respectively provided with water inlet pipes and water outlet pipes extending outwards from both ends, and are rotatably connected to the frame through the water inlet pipes and water outlet pipes; The two ends of the plurality of conduits are respectively connected to the water inlet pipe and the water outlet pipe, and the outer wall of the water outlet conduit away from the cylinder is surrounded by a plurality of drainage pipes, one end of the plurality of drainage pipes is connected to the water outlet pipe, and the other end is inclined to the same side; A protective cover covering the outer ends of the plurality of drainage pipes is fixedly mounted on the frame, and a discharge port is arranged at the bottom of the protective cover; A water pump is also arranged on the frame, the inlet of the water pump is communicated with the discharge port, and the outlet of the water pump is communicated with an end of the water inlet pipe away from the cylinder.

2. The method for preparing the Danzhi Jiangtang Capsule nanoparticles according to claim 1, characterized in that: The water inlet pipe is connected to a first seat plate at one end facing the cylinder, the first seat plate is detachably connected to the end of the cylinder, and a first conical water guide portion protruding into the water inlet pipe is provided on the first seat plate; The end of the water outlet pipe facing the cylinder is connected with a second seat plate, the second seat plate is detachably connected to the end of the cylinder, and the second seat plate is provided with a second conical water guide portion protruding into the water outlet pipe.

3. The method for preparing Danzhi Jiangtang Capsule nanoparticles according to claim 1, characterized in that: A radiator is arranged between the drain outlet and the inlet of the water pump, and the radiator includes a shunt pipe, a confluence pipe and a plurality of heat dissipation pipes. The shunt pipe and the confluence pipe are arranged in parallel, and the plurality of heat dissipation pipes are arranged in parallel between the shunt pipe and the confluence pipe, and the two ends are respectively connected to the shunt pipe and the confluence pipe, and a gap for air circulation is arranged between any two adjacent heat dissipation pipes.

4. The method for preparing Danzhi Jiangtang Capsule nanoparticles according to claim 3, characterized in that: A rotating shaft is rotatably connected to the frame, one end of the rotating shaft is rotatably connected to the frame, and a plurality of blades are arranged outside the other end. The rotating shaft is arranged parallel to the water outlet pipe, and the rotating shaft and the water outlet pipe are transmission-connected.

5. The method for preparing Danzhi Jiangtang Capsule nanoparticles according to claim 4, characterized in that: The heat dissipation pipe is provided with a heat conduction fin plate extending toward a side away from the rotating shaft.

6. The method for preparing the Danzhi Jiangtang Capsule nanoparticles according to claim 1, characterized in that: A sealing plate is provided at one end of the water inlet pipe away from the cylinder, and a plurality of through holes are opened on the sealing plate, and the plurality of through holes are evenly distributed with the center of the sealing plate as the center of a circle, and the plurality of through holes are arc-shaped strip holes, and the inner diameter of the plurality of through holes at one end facing the rotation direction is smaller than the hole diameter at the end facing away from the rotation direction; A hollow shell-shaped diverter cover is arranged outside the end of the water inlet pipe away from the cylinder body. The diverter cover is fixedly mounted on the frame and is connected to the outlet of the water pump through a pipeline. The diverter cover is a planar structure on the side facing the water inlet pipe, and a plurality of drainage holes corresponding to the plurality of through holes are opened on this side, and the aperture of the drainage hole is not less than the aperture of the larger end of the through hole.

7. The method for preparing Danzhi Jiangtang Capsule nanoparticles according to claim 6, characterized in that: The diverter cover is connected with a sleeve, and the sleeve is rotatably sleeved outside the water inlet pipe.

8. The method for preparing Danzhi Jiangtang Capsule nanoparticles according to claim 1, characterized in that: The outer surface of the cylinder is wrapped with a heat-conducting layer, a plurality of flow channels penetrating along the axial direction are provided in the heat-conducting layer, and the conduit is composed of the flow channels.

9. The method for preparing Danzhi Jiangtang Capsule nanoparticles according to claim 1, characterized in that: A liner is provided in the cylinder, and a spiral guide groove is provided on the inner wall of the liner; There are two liner tubes, and the spiral directions of the guide grooves opened on two adjacent liner tubes are opposite.

10. The method for preparing Danzhi Jiangtang Capsule nanoparticles according to claim 3, characterized in that: A water storage tank is arranged between the inlet of the water pump and the radiator.

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