Coating-drying-laminating-rolling equipment for intelligent continuous manufacturing of patch

Abstract

The invention provides intelligent coating-drying-laminating-rolling equipment for continuous manufacturing of patches. The continuous manufacturing equipment comprises a coating box, a drying box and a laminating-rolling box, and a medicine storage device, an online detection and process control device, a monitoring and adjusting device and a coating device are arranged in the coating box; the medicine storage device is directly connected with the automatic feeding device through a conveying hose, and the automatic feeding device is connected with the coating device through a conveying hose. According to the intelligent continuous manufacturing coating-drying-film laminating-winding device, all sensors are interconnected, integrated control is achieved, process parameters are recorded in real time, and production backtracking and process adjustment are facilitated; and meanwhile, the production process is automatically controlled, each link can be accurately controlled, and the product production process is strictly controlled, so that the product quality is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of automated production equipment, and in particular to an intelligent continuous manufacturing coating-drying-laminating-reeling equipment for patches. Background Art

[0002] As the largest organ in the human body, the skin area of ​​an adult can reach 2m². After administration through the skin, the drug will penetrate into the skin layers or enter the systemic circulation to produce local or systemic therapeutic effects. This drug delivery system that adheres to the human skin and delivers drugs through the skin to produce systemic and local therapeutic effects is called a transdermal and topical drug delivery system (TDS), also traditionally known as a patch, and is the third largest drug delivery system after oral and injection. Compared with traditional oral or injectable drugs, TDS can avoid the first-pass effect of the liver, avoid drug degradation in the gastrointestinal tract, prolong the effective action time, stabilize blood drug concentration, and reduce toxic and side effects; compared with oral drugs, TDS will reduce damage to organs such as the liver, making medication safer; at the same time, it can improve patient compliance, especially for some patients with uncontrolled autonomous behavior who have difficulty and high risk in using traditional drug delivery methods.

[0003] The continuous coating production equipment of TDS or patches integrates the feeding of semi-finished glue, the drying of glue, and the lamination and winding of the backing layer. It can continuously complete the coating, drying, lamination and lamination of TDS or patches, and obtain the patch composite film sample before cutting and packaging. This continuous production process determines the component content and coating thickness of the final product. Therefore, monitoring the key quality attributes of the product in this continuous production process is an important research topic. However, at present, research on the monitoring of the continuous production process of TDS or patches is relatively scarce at home and abroad. The quality evaluation of TDS patch finished products usually adopts offline detection, which is analyzed by ultraviolet visible spectroscopy or high performance liquid chromatography. Both methods include sample preparation steps such as dissolving, ultrasonication, diluting and filtering samples, which are very time-consuming.

[0004] In addition, in the process of TDS or patch production, drug glue coating often relies on manual operation, which has problems such as uneven coating, low efficiency, and unstable quality. In order to improve production efficiency and product quality, it is necessary to develop a highly automated, precisely controlled, thin-film intelligent continuous manufacturing coating-drying-laminating-winding equipment.

[0005] In view of this, the present invention is proposed. Summary of the invention

[0006] The purpose of the present invention is to provide intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches. The coater can realize intelligent operation, achieve uniform coating of drug glue, precise drying, lamination and thickness monitoring, reduce manual intervention, and enable the preparation process to be accurately controlled, thereby ensuring stable and reliable product quality; at the same time, a modular design is adopted between the various components, so that the various components are easy to adjust, disassemble and install, suitable for packaging materials of different specifications and types, and convenient for cleaning and maintenance.

[0007] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted: The present invention provides an intelligent continuous manufacturing coating-drying-film laminating-winding equipment for patches. The continuous manufacturing equipment comprises: a coating box, a drying box, and a film lamination-winding box, wherein a drug storage device, a near-infrared online detection and process control device, a monitoring and adjustment device, and a coating device are arranged in the coating box; the drug storage device is directly connected to an automatic feeding device via a conveying hose, and the automatic feeding device is connected to a coating device via a conveying hose; the near-infrared online detection and process control device is arranged at the starting end of the coating box; a drying box pipe is arranged outside the coating box, one side of the drying box pipe is connected to the coating device arranged in the coating box, and the other side is connected to the film lamination-winding box; a film lamination device, a drug winding device, a near-infrared online detection and process control device, and a monitoring and correction device are respectively arranged in the film lamination-winding box.

[0008] Preferably, as a further specific implementation, near-infrared online detection and process control devices are provided in the coating box and the laminating and winding box; a bracket and a scraper are provided in the coating device, a liquid level sensor is fixed on the bracket, a coater is provided directly below the liquid level sensor, and a monitoring and adjusting device is provided inside the coater, and the monitoring and adjusting device is used to monitor the thickness of the medicine film in the coater and the height of the scraper.

[0009] The continuous manufacturing equipment of the present invention is divided into three large devices, namely a coating box, a drying box, and a film lamination-winding box. The three are connected in sequence, so that the drug is coated in the coating box and then dried through the drying box pipeline, and finally enters the drug film lamination-winding box for monitoring, film lamination, winding, and correction of some drug patches of different thicknesses, thereby ensuring the quality of the patch drug.

[0010] The intelligent continuous manufacturing equipment for patches of the present invention adopts a near-infrared online detection and process control device to realize non-destructive, automated, digital process analysis and quality control of the production coating process. A near-infrared online detection and process control device is provided in the coating box (the starting end of coating) and in the laminating and winding box (the drying end, i.e. before laminating). Among them, a near-infrared online detection and process control device is provided in the coating box, and the near-infrared spectrum is processed by spectral preprocessing and characteristic wavelength screening methods, and a quantitative detection model of the properties of the intermediate glue liquid is established, which can quickly detect the quality attributes of the intermediate glue liquid, and provide a device function for realizing online detection and control of the coating glue liquid by near-infrared rapid detection technology. In addition, an online detection and process control device is installed in the laminating and winding box. A Fourier transform near-infrared spectrometer is used to collect the near-infrared spectrum of the drug film product after coating and drying, and different quantitative detection models for patch weight and active drug ingredient content are established. It can quickly detect the patch weight and active drug ingredient content of the patch coating-drying process product, and provide a non-destructive, automated, and digital process analysis technology equipment function for a TDS or patch production coating process.

[0011] The coating box is equipped with a feeding device, a coating device and a monitoring and adjusting device. The feeding device can stably feed the coating machine. The feeding device and the coating device are connected by a conveying hose to achieve drug delivery. The feeding device is linked with the monitoring and adjusting device to monitor the thickness and uniformity of the coated drug glue, record experimental data, and feed back the experimental data to adjust the height of the scraper. In addition, the coating device itself can automatically load materials. When there is a shortage of materials, its built-in monitoring device can detect and extract raw materials from the feeding device in time. The coating device is equipped with a coating device and a height adjustment device. The height adjustment device can precisely adjust the height of the scraper, thereby adjusting the thickness of the drug and ensuring the coating thickness.

[0012] The drug laminating and winding box is divided into a laminating device, a winding device and a monitoring and correcting device. The monitoring and correcting device can monitor the thickness of the drug film in real time, and correct the drug that is not properly attached or crooked, so as to ensure the quality of the patch drug.

[0013] The feeding device can pump the medicine in the storage device into the coating device. The feeding device mainly includes a peristaltic pump and a delivery hose. During operation, the medicine storage device mainly includes a medicine gel storage box, a liquid level sensor and a delivery hose. At the same time, the medicine in the medicine storage device can be delivered to the coating device through the delivery hose for subsequent processing. When the raw materials in the storage device are exhausted, the coating device cannot be fed. The monitoring device in the coating device can promptly issue an alarm to remind the operator to add raw materials to the storage device or replace the storage device.

[0014] Preferably, as a further specific embodiment, the coating device is provided with a bracket and a scraper, a liquid level sensor is fixed on the bracket, a coater is provided directly below the liquid level sensor, a monitoring and adjusting device is provided inside the coater, and the monitoring and adjusting device is used to monitor the thickness of the medicine film in the coater and the height of the scraper.

[0015] The coating device is a platform structure, and the bracket is an "L"-shaped hollow structure. The bracket is set on the platform structure and is used to fix the liquid level sensor. A film applicator is set just below the liquid level sensor. The liquid level sensor is used to monitor the amount of medicine in the film applicator. When the amount of medicine is small, the data can be fed back to the feeding device in time to transport the medicine to the film applicator.

[0016] The film applicator is equipped with a monitoring and adjustment device, which includes a near-infrared spectrometer integrated with a near-infrared process analysis module and a chemometric model, a height adjuster, a camera, and a sensor. The camera can take real-time photos of the coating process, which is convenient for operators to monitor the coating process in real time; the sensor is mainly composed of a magnetic powder clutch and a tension sensor, which can accurately control the tension of the drug film to prevent the drug film from rupturing when the tension is too high, or shrinking when the tension is too low.

[0017] When the drug raw materials are dissolved or dispersed evenly and mixed evenly with the adhesive, a drug-containing adhesive liquid is formed. After being coated to form a drug adhesive film, the drug adhesive film and the anti-adhesive film are pasted together. The built-in monitoring device of the applicator can monitor the adhesion between the drug adhesive film and the anti-adhesive film in real time to achieve precise fitting between the drug adhesive film and the anti-adhesive film.

[0018] The height adjustment instrument and the near infrared spectrometer are interconnected. The near infrared spectrometer is equipped with a scanning system to monitor the entire coating width and coating uniformity and record data. The height adjustment instrument can adjust the height of the scraper to adjust the thickness and uniformity of the drug film.

[0019] Preferably, as a further specific embodiment, the coating device is provided with a coating platform and a film applicator, the anti-sticking film is placed flat on the coating platform after passing through a passive roller, the film applicator is placed on the anti-sticking film, the anti-sticking film is connected to the tractor in the laminating and winding box on the other side to realize the movement of the anti-sticking film, and the anti-sticking film is connected to the unwinding device through a passive roller.

[0020] Preferably, as a further specific embodiment, the coating device is provided with a coating platform and a film applicator, the anti-sticking film is placed flat on the coating platform after passing through a passive roller, the film applicator is placed on the anti-sticking film, the anti-sticking film is connected to the tractor in the laminating and winding box on the other side to realize the movement of the anti-sticking film, and the anti-sticking film is connected to the unwinding device through a passive roller.

[0021] The anti-sticking film passes through the passive roller on the unwinding side and is laid flat on the coating platform. The other end passes through the drying pipe and enters the laminating and winding box and is connected to the tractor. The tractor provides power for the movement of the anti-sticking film to achieve continuous movement of the anti-sticking film from the unwinding side to the winding side.

[0022] The film applicator is placed on the surface of the anti-adhesive film on the coating platform, and the drug-containing glue is evenly coated on the anti-adhesive film through the gap formed by the film applicator and the scraper under the movement of the anti-adhesive film. The anti-adhesive film coated with the drug-containing glue on the surface is transported to the drying pipeline by traction for drying.

[0023] Preferably, as a further specific implementation manner, the top and rear of the coating box are provided with exhaust vents; and the coating box is also provided with a touch screen.

[0024] In the present invention, the data in all the sensing devices can be displayed on the touch screen, and the operator can manually adjust or monitor the displayed data. An exhaust port is provided in the coating box to realize the gas exchange inside the coating box. Since the coating box is connected to the drying duct, the exhaust port can prevent the temperature inside the coating box from being too high on the one hand, and on the other hand, the exhaust port can ensure the gas exchange inside the coating box to prevent the corrosion of equipment or drugs in the rainy season or under the condition of excessive humidity.

[0025] Preferably, as a further specific embodiment, a composite film unwinding shaft is arranged in the drug laminating and winding box, and the composite film unwinding shaft is connected to a monitoring and correcting device, and the monitoring and correcting device includes an anti-sticking film corrector, and the anti-sticking film corrector is directly connected to the composite film corrector and the drug corrector through a composite roller.

[0026] The main function of the drug laminating and winding box is to laminate and wind the drug-containing layer of the drug film. At the same time, the internal monitoring and correction devices can monitor the situation inside the drug laminating and winding box in real time; the correction device can promptly correct and repair the drug film that is not fitted, misaligned or has other problems.

[0027] After entering the drug laminating and winding box, the dried drug film is laminated and pasted with the backing material to form a patch composite film with a three-layer structure (anti-adhesive film layer, drug film layer, backing layer). Before pasting, the anti-adhesive film carrying the dried drug film is corrected and tested to keep its position on the composite roller unchanged. At the same time, the composite film is also corrected and tested to align with the edge of the anti-adhesive film after entering the composite roller for precise fitting. Preferably, as a further specific implementation, the drug deviation corrector is connected to a drug monitor, and the drug monitor is connected to a winder via a composite roller.

[0028] At this time, the drug monitor plays the role of quality inspection, and is mainly responsible for quality inspection of finished products that have completed correction, reducing human intervention and ensuring the quality of finished products.

[0029] Preferably, as a further specific implementation, the near-infrared online detection and process control device realizes non-destructive, automated, digital process analysis and quality control of the production coating process. Near-infrared online detection and process control devices are provided in the coating box (the starting end of coating) and in the laminating and winding box (the drying end, i.e. before laminating). Among them, a near-infrared online detection and process control device is provided in the coating box, and the near-infrared spectrum is processed by spectral preprocessing and characteristic wavelength screening methods to establish a quantitative detection model for the properties of the intermediate glue solution, which can provide rapid detection of the quality attributes of the intermediate glue solution, and provide a device function that realizes online detection and control of the coated intermediate glue solution by near-infrared rapid detection technology. In addition, an online detection and process control device is installed in the laminating and winding box. A Fourier transform near-infrared spectrometer is used to collect the near-infrared spectrum of the drug film product after coating and drying, and different quantitative detection models for patch weight and active drug ingredient content are established. The patch weight and active drug ingredient content of the drug film after the patch coating-drying process can be quickly detected, thereby providing a non-destructive, automated, and digital process analysis technology equipment function for the continuous production process of a TDS or patch.

[0030] Preferably, as a further specific embodiment, the drug monitor includes a fixing seat, and the fixing seat is used to fix the drug monitor in the drug laminating and winding box; the optical axis fixing seat is connected to the optical axis, and the optical axis is used to rotate and transport the drug film; the optical axis is also provided with two fixing frames, and a bracket is connected in the middle of the two fixing frames, and a clamp is provided in the middle position of the bracket, and the clamp fixes the measuring rod and the digital micrometer, and the clamp can adjust the fixed measuring rod and the digital micrometer forward and backward for monitoring drug films of different thicknesses.

[0031] The digital micrometer is set in front of the winder and is used for quality inspection of the drug film. It mainly detects the thickness of the drug film and returns the data to the near-infrared spectrometer. The data processing module in the near-infrared spectrometer can process the return data of the digital micrometer and other monitoring data, and transmit the processed data to the height adjuster. The height adjuster then adjusts the height of the scraper according to the data to ensure the thickness and uniformity of the drug film.

[0032] The clamp can fix the digital micrometer to prevent it from falling backward due to its own gravity; when the digital micrometer is set in the middle of the fixed frame, it can also ensure the accuracy of detection and prevent inaccurate detection results caused by edge detection.

[0033] Preferably, as a further specific embodiment, the drug laminating and winding box is provided with an air inlet on the outside, and the air inlet is connected to a heater, and the heater absorbs and heats the ambient air and sends it to the hot air inlet of the drying duct. The drug laminating and winding box is also provided with a touch screen and an air outlet on the outside.

[0034] Preferably, as a further specific implementation, the drying duct is composed of a plurality of drying ducts connected horizontally; the drying duct is also provided with a plurality of drying duct supporting legs.

[0035] Preferably, as a further specific implementation, the monitoring and correcting device has a built-in EPC control unit and a position monitoring sensor.

[0036] The finished composite medicine film after completing the above steps is rolled up by a rolling device arranged inside the film lamination-rolling box to obtain a prepared medicine roll for easy storage.

[0037] Compared with the prior art, the present invention has the following beneficial effects: (1) The sensors are interconnected to achieve integrated control, and the process parameters are recorded in real time, which is conducive to production traceability and process adjustment. At the same time, the production process is automated, which can achieve precise control of each link and strict control of the product production process, thereby ensuring product quality.

[0038] (2) Each component is designed to be easy to adjust, disassemble and install. It is suitable for packaging materials of different specifications and types, and is convenient for cleaning and maintenance. It can adapt to different working environments and conditions to ensure stable operation of the equipment.

[0039] (3) Adopt near-infrared online detection and process control devices to realize non-destructive, automated, digital process analysis and quality control of the production coating process. Near-infrared online detection and process control devices are installed in the coating box (the starting end of coating) and in the laminating and winding box (the drying end, i.e. before laminating). Among them, a near-infrared online detection and process control device is installed in the coating box, and the near-infrared spectrum is processed by spectral preprocessing and characteristic wavelength screening methods to establish a quantitative detection model for the properties of the intermediate glue liquid, which can provide rapid detection of the quality attributes of the intermediate glue liquid and provide a device function that realizes online detection and control of the coated intermediate glue liquid by near-infrared rapid detection technology. In addition, an online detection and process control device is installed in the lamination and winding box. A Fourier transform near-infrared spectrometer is used to collect the near-infrared spectrum of the drug film product after coating and drying, and different quantitative detection models for patch weight and active drug ingredient content are established. It can quickly detect the patch weight and active drug ingredient content of the patch coating-drying process product, and thus provide a non-destructive, automated, and digital process analysis technology equipment function for the production coating process of a transdermal drug delivery system. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the detailed description of the preferred embodiments below. The accompanying drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the present invention. Moreover, the same reference symbols are used throughout the accompanying drawings to represent the same components. In the accompanying drawings: Figure 1 : Machine structure diagram; Figure 2 : Schematic diagram of the drug storage device and the automatic feeding device; Figure 3 : Schematic diagram of drying pipeline; Figure 4 : Schematic diagram of the drug monitor structure; Figure 5 : Interior plan of the drug laminating / laminating-winding box.

[0041] The symbols in the accompanying drawings are: 1. Drug storage device; 2. Automatic feeding device; 3. Coating device; 4. Touch screen; 5. Exhaust vent; 6. Passive roller; 7. Anti-sticking film unwinding device; 8. Drying pipe; 9. Drying pipe supporting legs; 10. Touch screen; 11. Exhaust vent; 12. Retractor; 13. Anti-adhesive film deviation corrector; 14. Composite film unwinding shaft; 15. Heating box; 16. Winder; 17. Drug monitor; 18. Drug deviation corrector; 19. Composite film deviation corrector; 20. Window; 21. Peristaltic pump; 22. Back plate; 23. Delivery hose; 24. Liquid level sensor; 25. Delivery hose; 26. Coating platform; 27. Bracket; 28. Liquid level sensor; 29. ​​Drug glue storage box; 30. Anti-adhesive film; 31. Discharge port; 32. Film applicator; 33. Drug glue film; 34. Exhaust port; 35. Drying duct; 36. Drying duct; 37. Drying duct; 38. Hot air inlet of drying duct; 39. Air inlet; 40. Scraper; 41. Hot air outlet; 42. Medicine film; 43. Optical axis; 44. Optical axis fixing seat; 45. Fixing frame; 46. Measuring rod; 47. Clamp; 48. Bracket; 49. digital micrometer; 50. fixed frame; 51. back plate; 52. composite roller; 53. composite film; 54. Near infrared detector (coating start); 55. Near infrared detector (drying end) A: Coating box; B: Drug laminating and winding box; C: Drying box with drying pipe. DETAILED DESCRIPTION

[0042] The technical scheme of the present invention will be clearly and completely described below in conjunction with the accompanying drawings and specific embodiments, but it will be understood by those skilled in the art that the following described embodiments are part of embodiments of the present invention, rather than all embodiments, and are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative work are within the scope of protection of the present invention. If specific conditions are not specified in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer is not specified in the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0043] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0044] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0045] In order to more clearly explain the technical solution of the present invention, it is described in the form of specific embodiments below.

[0046] Example Device structure: The whole machine structure is as follows Figure 1 and Figure 3 As shown, A is a coating box, B is a drug laminating and winding box, and C is a drying duct of a drying box. The coating box A and the drug laminating and winding box B are connected through the drying duct C of the drying box. An exhaust port 5 is provided on the top of the coating box A, and a hot air outlet 41 is provided inside, which is used for gas circulation inside the coating box A to prevent the temperature inside the coating box A from being too high and can also effectively prevent moisture reversion; an air inlet 39 is provided on the side of the drug laminating and winding box B, and a drying duct hot air inlet 38 is provided at the same time. The drying duct hot air inlet 38 is connected to the heating box 15 through a hot air duct. This design can ensure that a relatively stable temperature is maintained inside the drug laminating and winding box B, and at the same time, it is conducive to gas circulation therein. A touch screen 4 is built into the coating box A, and a touch screen 10 is externally provided in the drug laminating and winding box B. The touch screen 4 and the touch screen 10 can respectively display the data returned by various monitoring devices inside the coating box A and the drug laminating and winding box B, and make manual adjustments.

[0047] Inside the coating box A, there are provided a drug storage device 1, an automatic feeding device 2 and a coating device 3. The relationship between the three is as follows: Figure 2 As shown, the drug storage device 1 , the automatic feeding device 2 and the coating device 3 are connected via a delivery hose 23 and a delivery hose 25 , and all three are arranged on the same back plate 22 .

[0048] The drug storage device 1 includes a drug gel storage box 29, which is a hollow box-type structure. A liquid level sensor 24 is arranged on the top of the box-type structure for monitoring the content of the drug in the drug gel storage box 29. The drug gel storage box 29 is connected to a delivery hose 23, and the delivery hose 23 is connected to a peristaltic pump 21. The peristaltic pump 21 is also connected to a delivery hose 25, and the delivery hose 25 is connected to a film applicator 32.

[0049] The film coater 32 has a built-in monitoring and adjustment device, which includes a near-infrared spectrometer, a height adjuster and a sensor that integrates a near-infrared process analysis module and a chemometric model; the above-mentioned device is integrated on the inner wall of the film coater 32, and a camera can be set at any position of the film coater 32 for real-time monitoring of the coating process. The film coater 32 includes a coating platform 26, on which a bracket 27 is set. The bracket 27 is an "L"-shaped hollow structure. The top of the bracket 27 can be used to fix the liquid level sensor 28, and the hollowing on the "L"-shaped top surface of the bracket 27 can make the liquid level sensor 28 slide so as to adjust the position of the liquid level sensor 28. The film coater 32 is provided with a scraper 40 for scraping the glue liquid. The bottom of the scraper 40 is provided with a drug-carrying plate to transport the prepared drug glue film 33. The prepared drug glue film 33 is continuously transported outward through the anti-adhesive film 30 of the drug-carrying plate and passes through the drying pipe of the drying box C. After drying, the drug film 33 enters the laminating and winding box B, and is covered with a backing material and laminated to form a three-layer patch composite film (anti-adhesive film layer, drug film layer, backing layer). A passive roller 6 is arranged below the coating device 3, and the passive roller 6 is connected to the coating device 3 and the anti-adhesive film unwinding device 7 through a shaft belt 53. The anti-adhesive film unwinding device 7 is used to place the anti-adhesive film.

[0050] Figure 3 The relationship between the coating box A, the drug laminating-laminating-winding box B and the drying duct of the drying box C is clearly shown. The anti-adhesive film 30 of the drug-carrying plate is directly connected to the drying duct 8, which is composed of a plurality of drying ducts 35-37 that are interconnected. Figure 3 35-37 are all connected to the drying pipes, and the surface of each drying pipe is provided with a transparent window 20, which can observe the real-time status of the medicine film in the drying pipe 8 with the naked eye; a plurality of drying pipe support legs 9 are provided at the bottom of the drying pipe 8 for supporting the drying pipe 8.

[0051] The other end of the drying duct 8 is connected to the drug laminating and winding box B, and the drug laminating and winding box B is provided with monitoring, deviation correction and film coating and winding structures. The above devices are connected to each other through the movement of the composite roller 52 and the shaft belt. A composite film unwinding shaft 14 is provided on one side of the drug laminating and winding box B. The composite film unwinding shaft 14 is used to place the composite film. The composite film unwinding shaft 14 is connected to the composite film deviation corrector 19 through the composite roller 52. The composite film deviation corrector 19 is connected to the anti-adhesive film deviation corrector 13 through the composite roller 52. The anti-adhesive film deviation corrector 13 is connected to the tractor 12. The tractor 12 is used to provide power for the movement between the composite roller 52 and the shaft belt. The tractor 12 is connected to the drug monitor 17 through the composite roller 52, and the drug monitor 17 is finally connected to the winder 16. The above devices are all arranged on the back plate 51.

[0052] Figure 4 It can be seen that the structure of the drug monitor 17 includes an optical axis fixing seat 44, which is fixed on the back plate 51. The optical axis fixing seat 44 fixes a cylindrical optical axis 43. A fixing frame 45 and a fixing frame 50 are arranged on the optical axis 43. The distance between the two fixing frames can be adjusted according to the width of the selected drug film. A bracket 48 is arranged between the fixing frame 45 and the fixing frame 50. A slide groove is arranged on the bracket 48. The digital micrometer 49 and the measuring rod 46 are fixed on the slide groove on the bracket 48 through a clamp 47. The digital micrometer 49 and the measuring rod 46 can slide on the slide groove of the bracket 48. The drug film 42 is continuously moved by the rotation of the optical axis 43.

[0053] Working method: 1. Equipment self-check Plug the equipment into the power supply, and then the coater starts self-checking to check whether all the passive rollers 6 and the composite roller 52 are stuck, and whether the shaft belt of the drug-loaded composite film 53 is broken or has other faults; at the same time, monitor whether all devices in the coater are faulty and whether all monitoring and correcting instruments are normal. After the equipment self-check is completed, it will be displayed on the touch screen 10 and the touch screen 4.

[0054] When it is detected that a certain part of the equipment fails, or the external material storage device does not contain enough material, the situation will be displayed on the touch screen 10 and the touch screen 4, and an alarm will be sounded.

[0055] 2. Working process After the equipment self-check is completed, the peristaltic pump 21 transports the glue from the glue storage box 29 to the applicator 32 through the delivery hose 25. The liquid level sensor 28 above the applicator 32 monitors the liquid level of the glue in the applicator 32 in real time. When the set upper limit threshold is reached, the peristaltic pump 21 will stop working, and the applicator 32 will continue to consume the glue. When the glue liquid level reaches the set lower limit threshold, the peristaltic pump 21 restarts, and the cycle continues. The liquid level sensor 24 monitors the glue liquid level in the glue storage box 29 in real time. When the alarm threshold is reached, the equipment sends an alarm message to remind the staff to replenish the glue.

[0056] During operation, the exhaust port 5 in the coating box A continuously exhausts air, and the peristaltic pump 21 can continuously pump the raw materials in the drug glue storage box 29 into the delivery hose 25 through the delivery hose 23, and the delivery hose 25 is directly connected to the film applicator 32. At the same time, the heating box 15 enters the hot air inlet 38 of the drying pipeline through the heating pipeline to heat the drug laminating and winding box B, and the air inlet 39 ensures the exchange of gas.

[0057] During the working process, the tractor 12 continuously pulls the anti-adhesive film 30 to move toward the winding end, and the raw material slurry flows out through the gap formed by the film applicator 32 and the scraper 40, and is evenly coated on the anti-adhesive film 30 to form a drug film 33 under the movement of the anti-adhesive film 30. The anti-adhesive film 30 carries the drug film 33 and enters the drying pipe 8 for preliminary drying, and then enters the drying pipes 35-37 in sequence for further drying; during this process, the operator can observe the state of the drug film 33 in real time from the window 20. After completing the drying step, the anti-adhesive film 30 carrying the drug film 33 enters the drug laminating-winding box B, in which the anti-adhesive film deviation corrector 13 will correct the position of the anti-adhesive film 30 carrying the drug film 33 to ensure that its position on the composite roller 52 is fixed, and at the same time, the composite film deviation corrector 19 will correct the position of the composite film 53 to ensure that it is aligned with the edge of the anti-adhesive film 30 on the composite roller 52 and is bonded to complete the lamination.

[0058] During this process, the near-infrared spectrometer, height adjuster, camera and sensor in the applicator 32 continuously scan and monitor the situation in the applicator 32 in real time, monitor the thickness, tension and working process of the drug film in real time, and feed back the experimental data to the processor of the touch screen 4 for processing in real time, and return the processed data to the sensor of the applicator 32 and adjust the height of the scraper 40.

[0059] The backing material is laminated with the anti-adhesive film 30 carrying the drug film 33 to form a three-layer patch composite film (anti-adhesive film layer, drug film layer, backing layer) after close adhesion, and enters the drug monitor 17. The optical axis 43 in the drug monitor 17 rotates continuously to make the drug film move continuously. During the rotation process, the digital micrometer 49 set on the bracket 48 performs quality inspection on the prepared finished drug, monitors the thickness and quality of the drug film, and returns the monitored data to the touch screen 10 for display, and returns the data to the near-infrared spectrometer. The data processing module in the near-infrared spectrometer can process the data and adjust the height of the scraper 40 for a second time. The prepared finished drug film is rolled up by the winder 16.

[0060] In the present invention, the drug film can be subjected to multiple deviation correction monitoring, and the finished product can be inspected at the same time; the various built-in monitoring devices can return data for processing, thereby realizing self-adjustment detection, reducing manual intervention in the process, and ensuring the stability of the finished product. At the same time, the modular design between the various components facilitates the size replacement, maintenance, disassembly and installation, reduces the cost of maintenance and operation, can adapt to different working environments and conditions, and realizes intelligent coating.

[0061] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. Intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches, characterized in that: The continuous manufacturing equipment comprises: a coating box, a drying box, and a film lamination-winding box, wherein a drug storage device, a near-infrared online detection and process control device, a monitoring and adjustment device, and a coating device are arranged in the coating box; the drug storage device is directly connected to an automatic feeding device via a conveying hose, and the automatic feeding device is connected to a coating device via a conveying hose; the near-infrared online detection and process control device is arranged at the starting end of the coating box; a drying box pipe is arranged outside the coating box, one side of the drying box pipe is connected to the coating device arranged in the coating box, and the other side is connected to the film lamination-winding box; a film lamination device, a drug winding device, a near-infrared online detection and process control device, and a monitoring and correction device are respectively arranged in the film lamination-winding box.

2. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 1, characterized in that: The coating box and the laminating and winding box are both provided with near-infrared online detection and process control devices; the coating device is provided with a bracket and a scraper, a liquid level sensor is fixed on the bracket, a coater is provided directly below the liquid level sensor, and a monitoring and adjusting device is provided inside the coater, and the monitoring and adjusting device is used to monitor the thickness of the medicine film in the coater and the height of the scraper.

3. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 1, characterized in that: The coating device is provided with a coating platform and a film applicator. The anti-sticking film is placed flat on the coating platform after passing through a passive roller. The film applicator is placed on the anti-sticking film. The anti-sticking film is connected to a tractor in a laminating and winding box on the other side to realize the movement of the anti-sticking film. The anti-sticking film is connected to the unwinding device through a passive roller.

4. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 1, characterized in that: The top and rear of the coating box are provided with air outlets; the coating box is also provided with a touch screen.

5. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 1, characterized in that: A composite film unwinding shaft is arranged in the drug laminating and winding box, and the composite film unwinding shaft is connected to a monitoring and correcting device, and the monitoring and correcting device includes an anti-adhesive film corrector, and the anti-adhesive film corrector is directly connected to the composite film corrector and the drug corrector through a composite roller.

6. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 5, characterized in that: The drug deviation corrector is connected to a drug monitor, and the drug monitor is connected to a winder via a composite roller.

7. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 6, characterized in that: The drug monitor includes a fixing seat, which is used to fix the drug monitor in the drug laminating and winding box; the optical axis fixing seat is connected to the optical axis, and the optical axis is used to rotate and transport the drug film; two fixing frames are also arranged on the optical axis, and a bracket is connected in the middle of the two fixing frames, and a clamp is arranged in the middle position of the bracket, and the clamp fixes the measuring rod and the digital micrometer, and the clamp can adjust the fixed measuring rod and the digital micrometer forward and backward, so as to monitor drug films of different thicknesses.

8. The intelligent continuous manufacturing coating-drying-film laminating-winding equipment for patches according to claim 1, characterized in that: A drying duct hot air inlet is arranged outside the drug laminating and winding box, and the drying duct hot air inlet is connected to the heating box through a heating duct; a touch screen and an exhaust port are also arranged outside the drug laminating and winding box.

9. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 1, characterized in that: The drying duct is composed of a plurality of drying ducts connected horizontally; the drying duct is also provided with a plurality of drying duct supporting legs.

10. The intelligent continuous manufacturing coating-drying-laminating-winding equipment for patches according to claim 1, characterized in that: The monitoring and correcting device has an EPC control unit and a position monitoring sensor built in.

Images