Dispensing machine and analysis device

Abstract

A multi-split dispenser (100) is provided with: a plurality of syringes (103) each comprising a plunger (101) and a housing (102); a drive motor (104) that drives the at least one plunger (101); a tip section (106) to which the dispensing tip (105) is attached; and tubes (107A, 107B) connecting the syringes (103) and the tip section (106), the outer diameter (109) of the housing (102) being larger than the pitch distance (108) of the dispensing tips (105), and the plurality of syringes (103) being arranged in a plurality of rows. As a result, it is possible to increase the diameter of the plunger and to dispense from a small volume to a large volume compared to the prior art.

Description

Technical Field

[0001] The present invention relates to a dispensing machine and an analyzing device. Background Art

[0002] As an example of a multi-dispensing device, the following is recorded in Patent Document 1: it comprises: a plurality of dispensing pressurizing units, which have syringes, pistons, solenoid valves, tubes and a piston driving unit for driving the pistons; a multi-nozzle unit, which has a plurality of nozzles capable of installing a plurality of nozzle tips at one end; and a controller, which drives the piston driving unit and drives the solenoid valve, and sets the solenoid valve between the syringe and the tube to connect the tube with the other end of the nozzle.

[0003] Prior art literature

[0004] Patent Literature

[0005] Patent Document 1: Japanese Patent Application Publication No. 2008-246363 Summary of the invention

[0006] Problems to be solved by the invention

[0007] In experiments and analyses in the field of biochemistry, a dispensing operation is sometimes performed to divide liquids such as test bodies and reagents and transfer and inject them into a sample reaction plate as a dedicated sample container. In this dispensing operation, a multi-unit dispensing device having a predetermined number of dispensing nozzles for sucking and discharging liquids is used.

[0008] The sample reaction plate is provided with a plurality of (for example, 96) small holes for collecting samples. The front end of a dispensing tip mounted on a dispensing nozzle is inserted into these small holes, and the liquid in the small holes is sucked into the dispensing tip and discharged, thereby performing dispensing.

[0009] When dispensing reagents and the like into a 96-well sample plate having 8×12 wells as a general sample reaction plate, faster dispensing can be achieved by using an 8-channel dispensing machine to perform a total of 12 dispensings as described in Patent Document 1, compared to 96 times of reagent dispensing by one dispensing machine. In addition, there is also a 96-channel dispensing machine as a method of faster dispensing.

[0010] Here, regarding the dispensing amount, the larger the diameter of the plunger of the dispensing machine, the shorter the distance the plunger moves for suction and discharge of the solution, and the larger the volume can be dispensed in a short time. On the other hand, the smaller the plunger diameter, the higher the accuracy of the solution volume can be, but the longer the distance the plunger moves in large-volume dispensing, the longer it takes to dispense.

[0011] In order to cope with the high density of sample reaction plates, multi-dispensing devices are required to be miniaturized to cope with various dispensing amounts from trace amounts to large volumes with a small pitch width.

[0012] In order to cope with large volumes, it is required to increase the plunger diameter as much as possible. This is because, as mentioned above, the larger the plunger diameter, the larger the volume can be dispensed even if the plunger moves a short distance, and the shorter the time can be.

[0013] On the other hand, since the pitch of the plunger of the multi-dispensing machine depends on the pitch of the holes of the sample reaction plate, there is a problem that the increase in the diameter of the plunger is restricted.

[0014] The present invention provides a dispensing machine and an analyzing device that can increase the plunger diameter compared to the conventional ones and can perform dispensing from a trace amount to a large volume.

[0015] Solutions to Solve Problems

[0016] The present invention includes multiple solutions to the above-mentioned problems. To cite one example, a dispensing machine comprises: multiple syringes, which are composed of a plunger and a shell; a drive motor, which drives at least one of the plungers; a front end portion, which is equipped with a dispensing tip; and a tube, which connects the syringe and the front end portion, wherein the outer diameter of the shell is larger than the configuration spacing distance of the dispensing tip, and the multiple syringes are arranged in multiple rows.

[0017] Effects of the Invention

[0018] According to the present invention, the plunger diameter can be increased compared to the related art, and dispensing from a minute amount to a large volume can be performed. Other problems, structures, and effects than those described above will become clear from the following description of the embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a diagram showing an example of the configuration of an analysis device including the multiple dispenser according to the first embodiment.

[0020] Figure 2 This is a diagram showing an example of the structure of the multi-unit dispensing machine according to the first embodiment.

[0021] Figure 3 yes Figure 2 AA section view of the.

[0022] Figure 4 It is a figure which shows the state when viewing an example of the structure of the multi-unit dispensing machine of 1st Embodiment from different angles.

[0023] Figure 5 This is a diagram showing an example of the structure of a multi-unit dispensing machine according to the second embodiment.

[0024] Figure 6 It is a figure which shows the state when viewing an example of the structure of the multi-unit dispensing machine of 2nd Embodiment from different angles.

[0025] Figure 7 This is a diagram showing an example of the structure of a multi-unit dispensing machine according to a third embodiment. DETAILED DESCRIPTION

[0026] Hereinafter, embodiments of the dispensing machine and the analyzing device of the present invention will be described using the drawings. It should be noted that in the drawings used in this specification, the same or corresponding components are denoted by the same or similar reference numerals, and duplicate descriptions of these components may be omitted.

[0027] <First Embodiment>

[0028] use Figures 1 to 4 A first embodiment of the dispensing machine and the analyzing device of the present invention will be described.

[0029] First, use Figure 1 The overall structure of the analysis device will be described. Figure 1 This is a block diagram showing an overview of the analysis device of this embodiment.

[0030] Figure 1 The analysis device 1 shown includes an analysis unit 10 composed of a sample storage unit 11, a multi-unit dispensing machine 100, an extraction unit 12, a single-unit dispensing machine 200, a reaction unit 13, consumables for the reaction unit 14, consumables for extraction 15, a reagent storage unit 16, and an operation unit 20.

[0031] The sample storage unit 11 is a part for inputting and collecting sample racks, temporarily storing one or more sample racks containing sample containers containing input samples to be analyzed, and temporarily storing one or more sample racks before collection.

[0032] The reaction unit consumables 14 is an area for placing and storing various consumables used for detecting the sample in the reaction unit 13 .

[0033] The extraction consumables 15 are used to set and store various consumables (dispensing tips 105 (see Figure 2 etc.) areas.

[0034] The reagent storage section 16 is an area for placing and storing various reagents used for detecting the sample in the reaction section 13 .

[0035] The multi-dispenser 100 is a part that dispenses samples from sample containers in a sample rack placed on the sample storage unit 11 into the collection unit 12, and moves above the sample storage unit 11 and the collection unit 12. Details of its structure will be described later.

[0036] The extraction unit 12 obtains a portion including biological molecules to be measured from the sample put into the sample storage unit 11 .

[0037] The single-piece dispensing machine 200 is a part that dispenses reagents into biological molecules from the reagent storage unit 16 to the extraction unit 12 or the reaction unit 13. It has a driving mechanism and a dispensing probe in the X-axis, Y-axis and Z-axis directions, and moves above the reagent storage unit 16, the extraction unit 12 and the reaction unit 13.

[0038] The reaction section 13 is a part that measures the biomolecules introduced into the sample storage section 11 and obtained by the extraction section 12 .

[0039] Here, the number of extraction units 12 and reaction units 13 is an example, and any number of more than one may be used. Similarly, although the example in which the multi-unit dispensing machine 100 or the single-unit dispensing machine 200 is also constituted by one each is shown, two or more may be constituted each.

[0040] Furthermore, the analysis unit 10 of the analysis device 1 is connected to the operation unit 20 by wire or wirelessly via a communication line.

[0041] The operation unit 20 is composed of a display unit, a control unit 21, and the like.

[0042] The display unit is a touch panel type display also serving as an input unit, and displays various information related to the analyzer 1, information related to the sample to be analyzed, and information required for executing the analysis. In addition, the input unit may include input devices such as a mouse and a keyboard.

[0043] The control unit 21 performs analytical calculation processing based on the measurement results in the reaction unit 13 and controls the operation of each unit in the analysis device 1 individually or as a whole.

[0044] The information storage unit is, for example, a recording medium storing control parameters corresponding to each unit, sample information related to various samples, and the like.

[0045] The control unit 21 can be constituted as hardware by a dedicated circuit substrate, or can be constituted by software executed by a computer. In the case of being constituted by hardware, it can be realized by integrating multiple operators that perform processing on a wiring substrate, or in a semiconductor chip or package. In the case of being constituted by software, it can be realized by carrying a high-speed general-purpose CPU on a computer and executing a program that performs the desired calculation processing. Existing devices can also be upgraded by recording a recording medium with the program recorded. In addition, these devices, circuits, and computers are connected through a wired or wireless network to appropriately send and receive data.

[0046] The above is the structure of the analysis device 1 of this embodiment.

[0047] The analysis flow in the analysis device 1 will be briefly described below.

[0048] A sample rack having sample containers mounted thereon is provided in the sample storage section 11, and when analysis is started, the sample is dispensed from the sample storage section 11 to the extraction section 12 by the multi-link dispenser 100. Thereafter, the extraction section 12 extracts biological molecules including the measurement object according to the request item. The extracted extract reacts with the reagent provided in the reagent storage section 16, and a predetermined reaction is carried out in the reaction section 13 and measurement is carried out.

[0049] In addition, the analysis device to which the present invention is applied is not limited to Figure 1 The illustrated method can be applied to various devices that automatically dispense liquids such as samples or reagents to analyze the samples.

[0050] For example, in the above Figure 1 In the analysis device, the method of dispensing reagents by the integrated dispensing machine 200 is shown, but as long as it is an analysis device that analyzes the same analysis items for a large number of test bodies, the dispensing machine of the present invention can also be used for reagent dispensing.

[0051] Next, refer to Figures 2 to 4 The specific structure of the multi-dispensing machine 100 according to this embodiment will be described. Figure 2 1 is a diagram showing an example of the structure of a multi-unit dispensing machine according to the first embodiment. Figure 3 yes Figure 2 Sectional view AA of Figure 4 It is a figure which shows the state when viewing an example of the structure of the multi-unit dispensing machine of 1st Embodiment from different angles.

[0052] The multi-unit dispensing machine 100 includes a syringe 103 , a drive motor 104 , a distal end portion 106 , tubes 107A and 107B, a ball screw 110 , a coupling 111 , and the like.

[0053] The syringe 103 is composed of a plunger 101 and a housing 102, and there are 8 of them in total. The housing 102 is a sleeve-shaped component that accommodates the plunger 101. The lower end side of the plunger 101 is respectively accommodated in the corresponding housing 102, and the upper end side is fixed to the connecting component 114. By the rotation drive of the drive motor 104, the connecting component 114 rises or falls, and the upper end side rises or falls accordingly.

[0054] A total of eight tip portions 106 for mounting the dispensing tips 105 are provided, and are connected to the respective syringes 103 in a one-to-one relationship via tubes 107A and 107B.

[0055] The driving motor 104 is connected to the connecting member 114 in the coupling 111, and by rotational driving, the connecting member 114 is raised or lowered by a predetermined amount based on the spacing specified by the ball screw 110. As a result, each plunger 101 whose end is fixed to the connecting member 114 is also raised or lowered, and the volume of the working fluid (here, air) in the housing 102 and the tubes 107A and 107B changes, thereby performing the dispensing or discharge action of the test body.

[0056] Here, in this embodiment, if Figure 2 , Figure 4 As shown, the spacing distance 108 between adjacent dispensing tips 105 is not changed in particular from the conventional multi-link dispensing machine, or is not changed by a predetermined value and is arranged in a straight line in the Y direction without changing the X-direction position. Figures 2 to 4 As shown, the syringe 103 side is arranged in multiple rows.

[0057] Furthermore, especially Figure 3 Therefore, at least one of the eight syringes 103 is arranged such that the X-direction position of the central axis thereof is offset from the X-direction position of the central axis of the dispensing head 105 or the tip 106 .

[0058] More specifically, the syringe 103 with the most negative Y direction in the figure is positioned the same as the third negative syringe 103, the fifth syringe 103, and the seventh syringe 103 in the X direction, and the second negative syringe 103, the fourth negative syringe 103, the sixth syringe 103, and the eighth syringe 103 in the X direction are positioned the same.

[0059] Furthermore, in this embodiment, if Figure 3 As shown, in order to realize not only micro-amount dispensing but also large-volume dispensing, the outer diameter 109 of the housing 102 is made larger than the spacing distance 108 between adjacent dispensing tips 105 .

[0060] In this way, by staggering the syringes 103 including the plungers 101 in the front and back directions, the outer diameter of the plungers 101 can be increased to twice the pitch distance 108 of the dispensing tips 105 in principle. In this case, the plunger diameter can be 4 to 10 times as compared to the case where the plungers are arranged horizontally, so the moving distance of the plunger 101 in the up-down direction (Z direction in the figure) is 1 / 16 to 1 / 100 times as compared to the previous structure, and the time can also be shortened to 1 / 16 to 1 / 100 times in simple calculation. Therefore, it is easy to handle not only micro-amount dispensing, but also large-volume dispensing, continuous dispensing, and deep wells.

[0061] In addition, the distance between each syringe 103 and the dispensing tip 105 is preferably constant in the plurality of tubes 107A and 107B. Figure 4 As shown, the distance can be obtained by making the tube 107A connecting the syringe 103 on the positive side in the X direction (the syringe 103 with the most negative position in the Y direction and the third negative syringe 103, the fifth syringe 103, and the seventh syringe 103 in the Y direction in the figure) and the dispensing nozzle 105 protrude toward the positive side in the X direction relative to the tube 107B connecting the syringe 103 on the negative side in the X direction compared with the syringe 103 on the positive side in the X direction (the second negative syringe 103, the fourth negative syringe 103, the sixth syringe 103, and the eighth syringe 103 in the figure) and the dispensing nozzle 105.

[0062] Alternatively, the volume of the working fluid between each syringe 103 and the dispensing tip 105 can be made constant in the plurality of tubes 107A and 107B. In this case, measures such as changing the cross-sectional area between the tubes 107A and 107B in the axial direction can be taken.

[0063] In the present embodiment, there is one drive motor 104 , and the volume of the sample dispensed by one ascending / descending operation (dispensing operation) can be made the same in the eight syringes 103 .

[0064] Next, the effects of this embodiment will be described.

[0065] In an analysis device 1 including a sample storage unit 11 for inserting a sample of the first embodiment of the present invention described above, a reaction unit 13 for measuring a specific substance in the sample inserted into the sample storage unit 11, a multi-unit dispensing machine 100 for dispensing any one of the sample inserted into the sample storage unit 11 or a reagent that reacts with the sample, and a control unit 21 for controlling the operation of each unit in the device, the multi-unit dispensing machine 100 includes a plurality of syringes 103 consisting of a plunger 101 and a housing 102, a driving motor 104 for driving at least one of the plungers 101, a front end portion 106 for mounting a dispensing tip 105, and tubes 107A and 107B for connecting the syringes 103 and the front end portion 106, an outer diameter 109 of the housing 102 is larger than a spacing distance 108 between the dispensing tips 105, and the plurality of syringes 103 are arranged in a plurality of rows.

[0066] Thus, the diameter of the plunger 101 is made larger than the diameter in the case where the plungers are arranged in a straight line as in the prior art, and it is possible to cope with micro-amount dispensing to large-volume dispensing.

[0067] In addition, multiple syringes 103 arranged in multiple rows are arranged alternately with each other, so the syringes 103 can be densely arranged and their diameters can be increased, thereby suppressing the enlargement of the surroundings of the syringes 103 and achieving an increase in the diameter of the plunger 101 while avoiding the enlargement of the multi-unit dispensing machine 100.

[0068] Furthermore, since only one drive motor 104 is provided, the drive system can be simplified, thereby achieving space saving and cost reduction.

[0069] <Second Embodiment>

[0070] use Figure 5 and Figure 6 A dispensing machine and an analyzing device according to a second embodiment of the present invention will be described. Figure 5 1 is a diagram showing an example of the structure of a multi-unit dispensing machine according to a second embodiment. Figure 6 It is a figure which shows the state when viewing an example of the structure of the multi-unit dispensing machine of 2nd Embodiment from different angles.

[0071] Figure 5 and Figure 6 The multi-dispensing machine 100A shown is different from the multi-dispensing machine 100 of the first embodiment in that it also includes pressure sensors 113A, 113B for detecting the pressure of tubes 107A, 107B, and pressure piping 112A, 112B connecting the tubes 107A, 107B and the pressure sensors 113A, 113B.

[0072] The multi-dispensing machine 100A of this embodiment is the same as the multi-dispensing machine 100 of the first embodiment in the following aspects: it is provided with 8 syringes 103; the configuration of the syringe 103 side is set to multiple rows and the 8 syringes 103 are arranged alternately; and the outer diameter 109 of the shell 102 is made larger than the spacing distance 108 between adjacent dispensing tips 105.

[0073] The difference is that, as described above, in addition to having a total of 8 pressure sensors 113A, 113B, the multi-dispensing machine 100A of this embodiment also has the pressure sensors 113A, 113B arranged in a staggered manner in multiple columns. More specifically, the multiple pressure sensors 113A, 113B are staggered in an opposite manner to the staggered arrangement of the multiple syringes 103.

[0074] like Figure 6 As shown, by arranging the pressure sensor 113A connected to the tube 107A connecting the syringe 103 on the positive side in the X direction (the most negative syringe 103 and the third negative syringe 103, the fifth syringe 103, and the seventh syringe 103 in the Y direction in the figure) and the dispensing tip 105 at a position closer to the negative side in the X direction than the pressure sensor 113B connected to the tube 107B connecting the syringe 103 on the negative side in the X direction in the figure (the second negative syringe 103, the fourth negative syringe 103, the sixth syringe 103, and the eighth syringe 103) and the dispensing tip 105, the plurality of pressure sensors 113A and 113B are staggered in the opposite direction to the staggered arrangement of the plurality of syringes 103.

[0075] In addition, it is preferable that the sum of the distance between each pressure sensor 113A, 113B and the syringe 103 and the distance between the syringe 103 and the dispensing tip 105 is constant in the plurality of tubes 107A, 107B and the pressure pipes 112A, 112B.

[0076] Alternatively, it is preferable that the sum of the volumes of the working fluid between each pressure sensor 113A, 113B and the syringe 103 and the volumes of the working fluid between the syringe 103 and the dispensing tip 105 be constant in the plurality of tubes 107A, 107B and the pressure pipes 112A, 112B.

[0077] The other structures and operations are substantially the same as those of the dispensing machine and the analyzing device of the first embodiment described above, and detailed description thereof will be omitted.

[0078] The dispensing machine and the analyzing device according to the second embodiment of the present invention can also achieve substantially the same effects as those of the dispensing machine and the analyzing device according to the first embodiment described above.

[0079] In addition, by providing a plurality of pressure sensors 113A, 113B for detecting the pressure of the tubes 107A, 107B and arranging them in a staggered manner in multiple rows, the constraints on the size of the pressure sensors 113A, 113B due to the narrow spacing between the configurations can be alleviated, thereby improving the degree of freedom in design.

[0080] Moreover, by staggering the plurality of pressure sensors 113A, 113 B in the opposite manner to the staggered arrangement of the plurality of syringes 103, it is possible to easily utilize the pressure piping 112 A which is longer than the pressure piping 112 B to absorb the volume difference of the lengthened portion of the tube 107B which is longer than the tube 107A, thereby further reducing the volume difference between the tubes 107A, 107B and the pressure piping 112A, 112B.

[0081] In addition, by having multiple pressure sensors 113A and 113B for detecting the pressure of the tubes 107A and 107B, the sum of the distance between each pressure sensor 113A and 113B and the syringe 103, and the distance between the syringe 103 and the dispensing tip 105 is constant in the multiple tubes 107A and 107B and the pressure piping 112A and 112B, or by having multiple pressure sensors 113A and 113B for detecting the pressure of the tubes 107A and 107B, the sum of the volume of the working fluid between each pressure sensor 113A and 113B and the syringe 103, and the volume of the working fluid between the syringe 103 and the dispensing tip 105 is constant in the multiple tubes 107A and 107B and the pressure piping 112A and 112B, it is possible to strongly suppress the difference in the amount of the test body dispensed by the multiple syringes 103, and to achieve higher precision dispensing.

[0082] <Third Embodiment>

[0083] use Figure 7 A dispensing machine and an analyzing device according to a third embodiment of the present invention will be described. Figure 7 This is a diagram showing an example of the structure of a multi-unit dispensing machine according to a third embodiment.

[0084] exist Figure 7 In the multi-dispensing machine 100B of the present embodiment shown, the configuration of the syringe 103 side is set to multiple rows in the same manner as the multi-dispensing machine 100 of the first embodiment and the multi-dispensing machine 100A of the second embodiment. In contrast, the syringes 103 are not arranged in a staggered manner, but the Y-direction positions of the syringes 103 on the positive side of the X-direction and the Y-direction positions of the syringes 103 on the negative side of the X-direction are arranged to be the same.

[0085] The other structures and operations are substantially the same as those of the dispensing machine and the analyzing device of the first embodiment described above, and detailed description thereof will be omitted.

[0086] Also in the dispensing machine and the analyzing device according to the third embodiment of the present invention, substantially the same effects as those of the dispensing machine and the analyzing device according to the first embodiment described above can be obtained.

[0087] <Others>

[0088] The present invention is not limited to the above-described embodiment, and includes various modifications. The above-described embodiment is described in detail to explain the present invention in an easily understandable manner, and is not necessarily limited to having all the described configurations.

[0089] In addition, a part of the structure of a certain embodiment may be replaced with the structure of another embodiment, and the structure of another embodiment may be added to the structure of a certain embodiment. In addition, for a part of the structure of each embodiment, other structures may be added, deleted, or replaced.

[0090] Explanation of symbols

[0091] 1—analyzer, 10—analyzer, 11—sample storage section (input section), 12—extraction section, 13—reaction section (measurement section), 14—consumables for reaction section, 15—consumables for extraction, 16—reagent storage section, 20—operation section, 21—control section, 100, 100A, 100B—multi-dispensing machine (dispensing machine), 101—plunger, 102—housing, 103—syringe, 104—drive motor, 105—dispensing tip, 106—front end, 107A, 107B—tube, 108—spacing distance, 109—outer diameter, 110—ball screw, 111—coupling, 112A, 112B—pressure piping, 113A, 113B—pressure sensor, 114—connecting component, 200—single-dispensing machine.

Claims

1. A dispensing machine, comprising: a plurality of syringes, each consisting of a plunger and a housing; a drive motor, which drives at least one of the plungers; a front end portion, on which a dispensing tip is mounted; and a tube, which connects the syringe and the front end portion, wherein the dispensing machine is characterized in that: The outer diameter of the housing is larger than the spacing distance of the dispensing tips. The plurality of syringes are arranged in a plurality of rows.

2. The dispensing machine according to claim 1, characterized in that: The plurality of syringes arranged in a plurality of rows are arranged in a staggered manner.

3. The dispensing machine according to claim 2, characterized in that: A plurality of pressure sensors are provided to detect the pressure of the tube, The pressure sensors are arranged in a staggered manner in a plurality of columns.

4. The dispensing machine according to claim 3, characterized in that: The plurality of pressure sensors are staggered in a manner opposite to the staggered arrangement of the plurality of syringes.

5. The dispensing machine according to claim 2, characterized in that: A plurality of pressure sensors are provided to detect the pressure of the tube, The sum of the distances between each of the pressure sensors and the syringe and the distance between the syringe and the dispensing tip is constant in the plurality of tubes.

6. The dispensing machine according to claim 2, characterized in that: A plurality of pressure sensors are provided to detect the pressure of the tube, The sum of the volumes of the working fluid between each of the pressure sensors and the syringe and the volumes of the working fluid between the syringe and the dispensing tip is constant in the plurality of tubes.

7. The dispensing machine according to claim 1, characterized in that: The number of the driving motor is one.

8. An analysis device comprising: an input section for inputting a sample; a measuring section for measuring a specific substance in the sample inputted into the input section; a dispensing machine for dispensing at least one of the sample inputted into the input section or a reagent that reacts with the sample; and a control section for controlling the operation of each section in the device, wherein the analysis device is characterized in that: The dispensing machine has: A plurality of syringes, which are composed of a plunger and a housing; a drive motor that drives at least one of the plungers; A front end portion, which is provided with a dispensing tip; and a tube connecting the syringe and the front end portion, The outer diameter of the housing is larger than the spacing distance of the dispensing tips. The plurality of syringes are arranged in a plurality of rows.

9. The analysis device according to claim 8, characterized in that The plurality of syringes arranged in a plurality of rows are arranged in a staggered manner.

10. The analysis device according to claim 9, characterized in that A plurality of pressure sensors are provided to detect the pressure of the tube, The pressure sensors are arranged in a staggered manner in a plurality of columns.

11. The analysis device according to claim 10, characterized in that The plurality of pressure sensors are staggered in a manner opposite to the staggered arrangement of the plurality of syringes.

12. The analysis device according to claim 9, characterized in that A plurality of pressure sensors are provided to detect the pressure of the tube, The sum of the distances between each of the pressure sensors and the syringe and the distance between the syringe and the dispensing tip is constant in the plurality of tubes.

13. The analysis device according to claim 9, characterized in that A plurality of pressure sensors are provided to detect the pressure of the tube, The sum of the volumes of the working fluid between each of the pressure sensors and the syringe and the volumes of the working fluid between the syringe and the dispensing tip is constant in the plurality of tubes.

14. The analysis device according to claim 8, characterized in that The number of the driving motor is one.

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