Composition with repairing effect as well as preparation method and application thereof

Abstract

The invention relates to the technical field of skin care products, and particularly discloses a composition with a repairing effect as well as a preparation method and application thereof. The composition with the repairing effect is formed by compounding an artemisia capillaris extract, a vibrio alginolyticus extract, a nannochloropsis oculata extract and a solvent. The traditional Chinese medicine composition has the advantage that the effect of repairing the skin more quickly is achieved.

Description

Technical Field

[0001] The present invention relates to the field of skin care products, and in particular to a composition with repairing effect, a preparation method thereof and an application thereof. Background Art

[0002] Skin care products are products used to repair the skin. Existing skin care products have a variety of functions and can solve different skin problems in a targeted manner. For allergic and damaged skin, skin care products with repair effects are usually used to repair the skin.

[0003] Existing skin care products with repairing effects usually add ingredients with soothing, anti-inflammatory and other effects to make the skin care products relieve skin discomfort and accelerate skin repair. Although existing skin care products with repairing effects can have a certain degree of soothing and anti-inflammatory effects, their effects are slow to take effect and the time to repair the skin is long. It is difficult to achieve the effect of quickly repairing the skin and it is difficult to meet the needs of consumers. Therefore, there is still room for improvement. Summary of the invention

[0004] In order to achieve a faster skin repair effect, the present application provides a composition with repair effect, a preparation method and an application thereof In the first aspect, the present application provides a composition with repairing effect, which adopts the following technical solution: A composition with repairing effect is a compound of an Artemisia capillaris extract, a Vibrio alginolyticus extract, a Nannochloropsis oculi extract and a solvent.

[0005] By adopting the above technical scheme, by adopting the compound of Artemisia capillaris extract, Vibrio alginolyticus extract and Nannochloropsis oculata extract, the active ingredients in Artemisia capillaris extract, Vibrio alginolyticus extract and Nannochloropsis oculata extract cooperate with each other, which can have significant soothing and anti-inflammatory effects, can quickly repair the skin, and promote the rapid recovery of the skin barrier on the skin surface. By quickly rebuilding the skin barrier, the skin no longer has to deal with the exposed state, and further attacks by external stimuli are limited, thereby making the skin heal faster, better promoting the rapid recovery of skin health, and achieving a faster effect of repairing the skin.

[0006] Preferably, the mass ratio of the Artemisia capillaris extract, the Vibrio alginolyticus extract, the Nannochloropsis oculata extract, and the solvent is 10-25: 0.00001-0.00003: 0.1-0.2: 74.79997-89.89999.

[0007] By adopting the above technical scheme and specifically selecting the mass ratios of Artemisia capillaris extract, Vibrio alginolyticus extract, Nannochloropsis oculata extract and solvent, the individual active ingredients can be better combined in specific ratios, thereby playing a better role in repairing the skin, further accelerating the speed of repairing the skin, and achieving a better effect of quickly repairing the skin.

[0008] In a second aspect, the present application provides a method for preparing a composition having a repairing effect, using the following technical solution: A method for preparing the above-mentioned composition with repairing efficacy is as follows: The Artemisia capillaris extract, the Vibrio alginolyticus extract, the Nannochloropsis oculi extract and the solvent are uniformly mixed to obtain a composition with repairing effect.

[0009] By adopting the above technical scheme, the prepared composition with repairing effect can quickly repair the skin, especially promote the repair of the skin barrier, so that the damaged skin parts can heal better and faster, and achieve a faster effect of repairing the skin.

[0010] In a third aspect, the present application provides an application of a composition having a repairing effect, using the following technical solution: An application of the above-mentioned composition with repairing efficacy, wherein the composition with repairing efficacy is added to skin care products to prepare skin care products with repairing efficacy.

[0011] By adopting the above technical solution, the prepared skin care products have the effect of quickly repairing the skin, can quickly soothe and reduce inflammation, and can promote the rapid repair of the skin barrier, so that the skin recovers health faster, and well meet the needs of consumers.

[0012] Preferably, the skin care product is skin care water.

[0013] By adopting the above technical solution, by making skin care products into skin care water, the skin care products are easier to be absorbed by the skin, so that the active substances in the composition with repairing effect can better care for the skin, take effect faster, and better play the effect of quickly repairing the skin.

[0014] Preferably, the skin care water is a compound of a solvent, a moisturizer, a preservative, an antioxidant, and a composition with a repairing effect.

[0015] By adopting the above technical scheme, by specifically selecting skin care water as a solvent, a moisturizer, a preservative, an antioxidant, and a composition with repairing effect, the quality of the skin care water is better, the stability is better, and the effect of repairing the skin is better.

[0016] Preferably, the mass ratio of the solvent, the moisturizer, the preservative, the antioxidant, and the composition with repairing effect is 87.3-92.7:6-10:0.4-0.6:0.4-0.6:0.5-1.5.

[0017] By adopting the above technical scheme and specifically selecting the mass ratio of the solvent, moisturizer, preservative, antioxidant and the composition with repairing effect, the skin care effect is made more significant and the skin can be repaired better and faster.

[0018] Preferably, the moisturizing agent is a compound of glycerol and butylene glycol, and the mass ratio of the glycerol to butylene glycol is 2-4:4-6.

[0019] By adopting the above technical solution and specifically selecting a moisturizer as a compound of glycerin and butylene glycol, the moisturizing effect of the skin care water is improved, which helps to assist skin repair, makes the skin recover faster, and has a better skin care effect.

[0020] Preferably, the preservative is hexylene glycol.

[0021] By adopting the above technical solution and specifically selecting hexylene glycol as the preservative, the skin care water has a longer shelf life and is less irritating to the skin, thereby reducing skin irritation caused by the preservative, thereby achieving a better skin repair effect.

[0022] Preferably, the antioxidant is p-hydroxyacetophenone.

[0023] By adopting the above technical solution and specifically selecting parahydroxyacetophenone as the antioxidant, the quality of the skin care water is made more stable, the effect of repairing the skin is better, and at the same time, the irritation is lower and the product quality is higher.

[0024] In summary, this application has the following beneficial effects: 1. Since the present application adopts a compound of Artemisia capillaris extract, Vibrio alginolyticus extract and Nannochloropsis oculi extract, the active ingredients in Artemisia capillaris extract, Vibrio alginolyticus extract and Nannochloropsis oculi extract cooperate with each other, which can have significant soothing and anti-inflammatory effects, can quickly repair the skin, and promote the rapid recovery of the skin barrier on the skin surface. By quickly rebuilding the skin barrier, the skin no longer has to deal with the exposed state, and further attacks by external stimuli are limited, thereby making the skin heal faster, better promoting the rapid recovery of skin health, and achieving a faster effect of repairing the skin.

[0025] 2. In the present application, it is preferred to specifically select the mass ratio of Artemisia capillaris extract, Vibrio alginolyticus extract, Nannochloropsis oculata extract, and solvent so that the active ingredients are better matched in a specific ratio, thereby exerting a better skin repair effect, further accelerating the speed of skin repair, and achieving a better effect of rapid skin repair. DETAILED DESCRIPTION

[0026] The present application is further described in detail below in conjunction with embodiments.

[0027] Example 1 A composition with repairing effect, comprising the following components: Artemisia capillaris extract, Vibrio alginolyticus extract, Nannochloropsis oculata extract, solvent.

[0028] The Artemisia capillaris extract was purchased from Yantai Oriental Chemical Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0029] The Vibrio alginolyticus extract was purchased from Guangzhou Derui Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0030] The extract of Nannochloropsis oculi was purchased from Guangzhou Derui Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0031] The solvent was deionized water, which was commercially available.

[0032] The preparation method of the composition with repairing effect is as follows: 10 kg of Artemisia capillaris extract, 0.00001 kg of Vibrio alginolyticus extract, 0.1 kg of Nannochloropsis oculata extract and 89.89999 kg of deionized water were put into a stirring kettle at a speed of 60 r / min and stirred for 10 minutes to obtain a composition with repairing effect.

[0033] Example 2 A composition with repairing effect, comprising the following components: Artemisia capillaris extract, Vibrio alginolyticus extract, Nannochloropsis oculata extract, solvent.

[0034] The Artemisia capillaris extract was purchased from Yantai Oriental Chemical Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0035] The Vibrio alginolyticus extract was purchased from Guangzhou Derui Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0036] The extract of Nannochloropsis oculi was purchased from Guangzhou Derui Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0037] The solvent was deionized water, which was commercially available.

[0038] The preparation method of the composition with repairing effect is as follows: 17.5 kg of Artemisia capillaris extract, 0.00002 kg of Vibrio alginolyticus extract, 0.15 kg of Nannochloropsis oculata extract and 82.34998 kg of deionized water were put into a stirring kettle at a speed of 60 r / min and stirred for 10 minutes to obtain a composition with repairing effect.

[0039] Example 3 A composition with repairing effect, comprising the following components: Artemisia capillaris extract, Vibrio alginolyticus extract, Nannochloropsis oculata extract, solvent.

[0040] The Artemisia capillaris extract was purchased from Yantai Oriental Chemical Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0041] The Vibrio alginolyticus extract was purchased from Guangzhou Derui Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0042] The extract of Nannochloropsis oculi was purchased from Guangzhou Derui Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0043] The solvent was deionized water, which was commercially available.

[0044] The preparation method of the composition with repairing effect is as follows: 25 kg of Artemisia capillaris extract, 0.00003 kg of Vibrio alginolyticus extract, 0.2 kg of Nannochloropsis oculata extract and 74.79997 kg of deionized water were put into a stirring kettle at a speed of 60 r / min and stirred for 10 minutes to obtain a composition with repairing effect.

[0045] Comparative Example 1 A composition with repairing effect, compared with Example 2, the only difference is: An equal amount of chamomile extract was used to replace the Artemisia capillaris extract.

[0046] Chamomile extract was purchased from Xi'an Jiatian Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0047] Comparative Example 2 A composition with repairing effect, compared with Example 2, the only difference is: The Vibrio alginolyticus extract was replaced with an equal amount of Centella asiatica extract.

[0048] Centella asiatica extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0049] Comparative Example 3 A composition with repairing effect, compared with Example 2, the only difference is: An equal amount of the Nannochloropsis oculata extract was replaced with lavender extract.

[0050] Lavender extract was purchased from Shaanxi Tianshengyuan Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0051] Comparative Example 4 A composition with repairing effect, compared with Example 2, the only difference is: An equal amount of chamomile extract was used to replace the Artemisia capillaris extract, an equal amount of Centella asiatica extract was used to replace the Vibrio alginolyticus extract, and an equal amount of lavender extract was used to replace the Nannochloropsis oculata extract.

[0052] Chamomile extract was purchased from Xi'an Jiatian Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0053] Centella asiatica extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0054] Lavender extract was purchased from Shaanxi Tianshengyuan Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0055] Application Example 1 A skin care water, comprising the following components: Solvents, moisturizers, preservatives, antioxidants, compositions with restorative properties.

[0056] The solvent was deionized water, which was commercially available.

[0057] The moisturizer is a compound of glycerin and butylene glycol.

[0058] Glycerol was purchased from Shandong Yijia Chemical Co., Ltd.

[0059] Butanediol was purchased from Nanjing Xinhuayuan Chemical Co., Ltd., 1,3-butanediol.

[0060] The preservative was hexylene glycol, which was purchased from Xi'an Hongyao Pharmaceutical Excipients Co., Ltd.

[0061] The antioxidant was p-hydroxyacetophenone, which was purchased from Wuhan Smack Biotechnology Co., Ltd.

[0062] The composition with repairing effect is the composition with repairing effect of Example 1.

[0063] The preparation method of skin care water is as follows: Step 1), 92.7 kg of deionized water, 2 kg of glycerol, 4 kg of butanediol, and 0.4 kg of p-hydroxyacetophenone were added to an emulsifying pot, heated to 85°C, homogenized and dispersed at 2500 r / min for 5 minutes, rotated at 120 r / min, stirred for 15 minutes, and cooled.

[0064] Step 2), cool to 35°C, rotate at 120r / min, add 0.4kg hexanediol while stirring, and stir to dissolve evenly.

[0065] Step 3), add 0.5 kg of the composition with repairing effect, rotate at 120 r / min, stir for 10 min, filter the material, and obtain skin care water.

[0066] Application Example 2 A skin care water, comprising the following components: Solvents, moisturizers, preservatives, antioxidants, compositions with restorative properties.

[0067] The solvent was deionized water, which was commercially available.

[0068] The moisturizer is a compound of glycerin and butylene glycol.

[0069] Glycerol was purchased from Shandong Yijia Chemical Co., Ltd.

[0070] Butanediol was purchased from Nanjing Xinhuayuan Chemical Co., Ltd., 1,3-butanediol.

[0071] The preservative was hexylene glycol, which was purchased from Xi'an Hongyao Pharmaceutical Excipients Co., Ltd.

[0072] The antioxidant was p-hydroxyacetophenone, which was purchased from Wuhan Smack Biotechnology Co., Ltd.

[0073] The composition with repairing effect is the composition with repairing effect of Example 1.

[0074] The preparation method of skin care water is as follows: Step 1), 90kg deionized water, 3kg glycerol, 5kg butylene glycol, and 0.5kg p-hydroxyacetophenone were put into an emulsifying pot, heated to 85°C, homogenized and dispersed at 2500r / min for 5min, rotated at 120r / min, stirred for 15min, and cooled.

[0075] Step 2), cool to 35°C, rotate at 120r / min, add 0.5kg hexanediol while stirring, and stir to dissolve evenly.

[0076] Step 3), add 1 kg of the composition with repairing effect, rotate at 120 r / min, stir for 10 min, filter the material, and obtain skin care water.

[0077] Application Example 3 A skin care water, comprising the following components: Solvents, moisturizers, preservatives, antioxidants, compositions with restorative properties.

[0078] The solvent was deionized water, which was commercially available.

[0079] The moisturizer is a compound of glycerin and butylene glycol.

[0080] Glycerol was purchased from Shandong Yijia Chemical Co., Ltd.

[0081] Butanediol was purchased from Nanjing Xinhuayuan Chemical Co., Ltd., 1,3-butanediol.

[0082] The preservative was hexylene glycol, which was purchased from Xi'an Hongyao Pharmaceutical Excipients Co., Ltd.

[0083] The antioxidant was p-hydroxyacetophenone, which was purchased from Wuhan Smack Biotechnology Co., Ltd.

[0084] The composition with repairing effect is the composition with repairing effect of Example 1.

[0085] The preparation method of skin care water is as follows: Step 1), 87.3 kg of deionized water, 4 kg of glycerol, 6 kg of butanediol, and 0.6 kg of p-hydroxyacetophenone were added to an emulsifying pot, heated to 85°C, homogenized and dispersed at 2500 r / min for 5 minutes, rotated at 120 r / min, stirred for 15 minutes, and cooled.

[0086] Step 2), cool to 35°C, rotate at 120r / min, add 0.6kg hexanediol while stirring, and stir to dissolve evenly.

[0087] Step 3), add 1.5 kg of the composition with repairing effect, rotate at 120 r / min, stir for 10 min, filter the material, and obtain skin care water.

[0088] Experiment 1 The hyaluronidase activity inhibition rate of the test samples prepared from the compositions with repairing efficacy of each embodiment and comparative example was detected.

[0089] Experimental methods 1. Take 99g of deionized water and 1g of the composition with repairing effect, mix them evenly, and prepare a test sample with a concentration of 1%.

[0090] 2. The sample reacts with the hyaluronidase solution.

[0091] 3. Test the absorbance at 530 nm.

[0092] 4. Calculate the inhibition rate of hyaluronidase activity. The calculation formula of hyaluronidase activity inhibition rate is: Hyaluronidase activity inhibition rate (%) = [1-(A2 / A1)] × 100% Where: A1—mean absorbance of blank test; A2—is the average absorbance of the sample to be tested.

[0093] Experiment 2 A number of volunteers were recruited and divided into groups to use the test samples prepared from the compositions with repairing effects of the embodiments and comparative examples to detect the transepidermal water loss (TEWL value) and the skin hemoglobin content. Each group consisted of 30 volunteers.

[0094] Testing Process D0: 1) Volunteer sign-in The subjects exposed the test area (face) and signed an informed consent form.

[0095] 2) Clean the test area The subjects cleansed their entire face uniformly with warm water and wiped it clean with dry tissue.

[0096] 3) Expose the test area and wait The subjects exposed the test part (face) and sat quietly in a laboratory with a temperature of 21±1℃ and 50±5%RH for 30min.

[0097] 4) Volunteer screening ①Laboratory technicians use Tewameter to test the transepidermal water loss of the subject's cheek 2 cm near the nose; ②Only those with TEWL>15g / m² / h were included in the group.

[0098] 5) Test subject's skin basic value After enrollment, the subjects sat in a laboratory at a temperature of 21±1°C and 50±10%RH and were not allowed to drink water or beverages; The face is exposed, in a testing state, and remains relaxed; The transepidermal water loss (TEWL value) and skin hemoglobin content in the cheek area 2 cm near the nose were tested, and each value was measured 3 times.

[0099] 6) Laboratory technicians instruct subjects on how to use the product according to the product usage requirements and site of use.

[0100] 7) The laboratory technician numbers the samples and records their weights. The subjects receive the samples and leave the laboratory.

[0101] D28 1) Follow-up interview with subjects The laboratory technicians inquired about the subjects' use of the samples and adverse reaction follow-up. The subjects handed over the samples and recorded the sample weighing.

[0102] 2) Clean the test area The subjects cleaned their entire face with warm water and dried their skin with dry facial tissue.

[0103] 3) Expose the test area and wait Expose the test area (face), sit quietly in a laboratory at 21±1℃ and 50±10% RH for 30min, and complete the questionnaire at the same time.

[0104] 4) On the 28th day, the skin parameters of the cheek 2 cm near the nose were measured, including transepidermal water loss (TEWL) and skin hemoglobin content. Each value was measured 3 times.

[0105] 5) Testing of the same subject must be completed by the same tester using the same instrument.

[0106] 6) Clean the test probe with deionized water, wipe it dry with dry tissue, and wait for the next use.

[0107] The specific experimental data of Experiment 1-2 are shown in Table 1.

[0108] Table 1

[0109] According to the data comparison of each embodiment and comparative example in Table 1, the soothing, anti-inflammatory and skin barrier repair effects of each embodiment are significantly better than those of each comparative example, which proves that the special combination of Artemisia capillaris extract, Vibrio alginolyticus extract and Nannochloropsis oculi extract in each embodiment can exert a significant synergistic effect, thereby quickly eliminating discomfort of the skin, promoting rapid recovery of skin health, and achieving a faster effect of repairing the skin.

[0110] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but such modifications are protected by patent law as long as they are within the scope of the claims of the present application.

Claims

1. A composition with repairing effect, characterized in that: The composition with repairing effect is a compound of Artemisia capillaris extract, Vibrio alginolyticus extract, Nannochloropsis oculi extract and solvent.

2. A composition with repairing effect according to claim 1, characterized in that: The mass ratio of the Artemisia capillaris extract, the Vibrio alginolyticus extract, the Nannochloropsis oculata extract, and the solvent is 10-25: 0.00001-0.00003：0.1-0.2：74.79997-89.89999。 3. A method for preparing the composition with repairing effect according to claim 1 or 2, characterized in that: The preparation method of the composition with repairing effect is as follows: The Artemisia capillaris extract, the Vibrio alginolyticus extract, the Nannochloropsis oculi extract and the solvent are uniformly mixed to obtain a composition with repairing effect.

4. An application of the composition with repairing effect according to claim 1 or 2, characterized in that: The composition with repairing effect is added into skin care products to prepare skin care products with repairing effect.

5. The use of a composition with repairing effect according to claim 4, characterized in that: The skin care product is skin care water.

6. The use of a composition with repairing effect according to claim 5, characterized in that: The skin care water is a compound of a solvent, a moisturizer, a preservative, an antioxidant, and a composition with a repairing effect.

7. The use of a composition with repairing effect according to claim 6, characterized in that: The mass ratio of the solvent, moisturizer, preservative, antioxidant and the composition with repairing effect is 87.3-92.7:6-10:0.4-0.6:0.4-0.6:0.5-1.

5.

8. The use of a composition with repairing effect according to claim 7, characterized in that: The moisturizing agent is a compound of glycerin and butylene glycol, and the mass ratio of the glycerin to butylene glycol is 2-4:4-6.

9. The use of a composition with repairing effect according to claim 7, characterized in that: The preservative is hexylene glycol.

10. The use of a composition with repairing effect according to claim 7, characterized in that: The antioxidant is p-hydroxyacetophenone.

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