A sterile transport device for freeze-dried drugs for injection and its use method

Abstract

The present invention discloses an aseptic transfer device for injectable freeze-dried drugs and a method for using the same, relating to the field of material transfer technology, comprising a box body, the interior of the box body being configured as a storage cavity, a bottom plate being installed at the bottom of the storage cavity, a first moving part being fixedly connected to the inner wall of the other opposite side surface of the box body located at the storage cavity position, a moving output end of the first moving part being fixedly connected to a first connecting frame placed horizontally, a sterilization lamp being fixedly installed below the first connecting frame, a first scanning part being fixedly connected to the top middle portion of the first connecting frame, a liquid storage tank being provided at the top of the box body, a sterilization liquid being stored in the liquid storage tank, a transfer lifting part being provided on the outer side of the box door, an output end of the transfer lifting part being fixedly connected to a support rod, a lifting frame being fixedly installed at the bottom of the support rod, the device realizes the intelligent transfer and aseptic processing process of freeze-dried drugs.

Description

Technical Field

[0001] The present invention relates to the technical field of material transportation, in particular to a sterile transportation device for freeze-dried injection drugs and a method for using the device. Background Art

[0002] Lyophilized injectable drugs are an important form of preparation in the modern pharmaceutical industry. Their production process involves multiple key links, including aseptic packaging, freeze-drying, and aseptic transportation. Lyophilization technology freezes the drug solution at low temperatures and then sublimates it under vacuum conditions to remove moisture, thereby obtaining a stable and easy-to-store powdered injection.

[0003] In the production process of freeze-dried drugs, aseptic transfer equipment plays a vital role, mainly involving canning, packaging, loading and unloading of packaging boxes, etc. Each link needs to strictly control the risk of contamination to ensure the sterility and quality of the product.

[0004] The transportation process of pharmaceutical packaging boxes can also be understood as the storage and transportation of semi-finished products. The boxes carrying the transportation boxes usually need to enter different levels of clean environments to ensure the sterile conditions of the transportation process. In addition, in the aseptic conversion process, manual intervention is usually reduced to reduce the risk of contact for operators. However, in actual transportation, most people still use macro-control of the aseptic environment and manual handling to move the pharmaceutical packaging boxes into the box. Combined with the current development needs of intelligent manufacturing, how to realize the intelligent aseptic transportation of products has become an urgent problem to be solved by people in this field. Summary of the Invention

[0005] The object of the present invention is to provide a sterile transport device for freeze-dried injection drugs and a method of using the same to solve the problems raised in the above background technology.

[0006] In order to solve the above technical problems, the present invention provides the following technical solutions: an aseptic transport device for freeze-dried drugs for injection, comprising a box body, the interior of the box body being configured as a storage cavity, a group of box doors being rotatably mounted on surfaces of opposite sides of the box body at the storage cavity position, a bottom plate being mounted on the bottom of the storage cavity, a first moving part being fixedly connected to the inner wall of the other opposite side surface of the box body at the storage cavity position, a moving output end of the first moving part being fixedly connected to a first connecting frame placed horizontally, a sterilization lamp being fixedly mounted below the first connecting frame, a first scanning part being fixedly connected to the top middle portion of the first connecting frame, a liquid storage tank being arranged on the top of the box body, and a sterilization liquid being stored in the liquid storage tank;

[0007] The outer side of the box door is provided with a transfer lifting part, the output end of the transfer lifting part is fixedly connected to the support rod, the bottom of the support rod is fixedly installed with a lifting frame, the middle part of the frame body of the lifting frame close to the box body is fixedly connected to the first clamping part, and a second clamping part is provided below the first clamping part. The lifting frame is located above the middle of the first clamping part and is fixed with a first telescopic part, the downward output end of the first telescopic part is fixedly connected to the first clamping part, and the first clamping part is evenly penetrated all around and fixedly connected to the suction part;

[0008] A data receiving terminal is provided on the outside of the box or the transfer lifting part, a first data processing terminal is provided at the transfer lifting part, a second data processing terminal is provided on the box, an infection monitoring part is installed on the surface of the support rod, an air inlet pipe is passed through the side wall of the infection monitoring part, a humidity detector is installed at the air inlet pipe, an air outlet pipe is passed through the top of the infection monitoring part, a partition cavity is provided on the upper part of the interior of the infection monitoring part, a monitoring cavity is provided in the middle part of the interior, a dust collection pump is provided at the lower end of the air outlet pipe inside the partition cavity, the monitoring cavity is communicated with the air inlet pipe, the suction parts are connected to the air inlet pipe, and a second scanning part and a display panel are respectively provided on both sides of the monitoring cavity along the airflow direction.

[0009] The present invention further describes that a first pump body is fixedly connected to one side of the top of the first connecting frame, the input end of the first pump body is connected to the liquid storage tank through a pipeline, and a plurality of first atomization parts are installed through the surface of the first connecting frame, and the plurality of first atomization parts are communicated with the output end of the first pump body.

[0010] The present invention further describes that the bottom height of the suction part is consistent with the bottom height of the first clamping part, and the diameter length of the lower end of the suction part is not less than the diameter length of the middle and upper end of the suction part, and the outer surface of the middle and upper end of the suction part passes through and is slidably connected to the frame body of the lifting frame.

[0011] The present invention further describes that a pushing assembly is also provided on the lifting frame, and the pushing assembly includes a third driving part fixed on the lifting frame, the output end of the third driving part is transmission-connected to a conveyor belt, the other end of the conveyor belt is supported and connected to a supporting part, the surface of the conveyor belt located below is fixedly connected to a fixed block, the bottom surface of the fixed block is fixedly connected to a connecting block, and the bottom surface of the connecting block is fixedly connected to an L-shaped block.

[0012] The present invention further describes that the L-shaped block is fixedly connected to at least one set of second sliders toward the upper surface of the lifting frame body, and a second slide rail is fixedly connected to the position of the second slider at the bottom of the lifting frame body, and the second slide rail is slidably connected to the second slider, and a push block is fixedly connected to one end of the second slide rail close to the first clamping part.

[0013] The present invention further states that the first data processing end is signal-connected to the dust collection pump, the second scanning unit, and the humidity detector to monitor the infection status of particulate debris on the surface of the packaging box and establish an infection prediction coefficient Ψ to represent the degree of infection;

[0014]

[0015] in, The environmental humidity is determined and recorded as the environmental impact coefficient. The scanning area of the second scanning unit is recorded as R. The second scanning unit determines the debris particle ratio by shooting the area occupied by the debris particles in the R area, which is recorded as r. i , the maximum allowable proportion of debris particles is pre-set to r max , i is the serial number of the clamped packaging box.

[0016] The present invention further describes that a liquid pump is installed on the top of the storage cavity of the box body, and the liquid pump is connected to a flow part through a pipeline. The flow part is connected to the liquid storage tank by a pipeline. A sterilization tube is fixedly installed above the side wall of the storage cavity, and several second atomization parts are evenly installed on the surface of the sterilization tube facing the inside of the storage cavity. The sterilization tube and the flow part are connected by a pipeline and a control valve is provided on the pipeline.

[0017] The present invention further describes that a plurality of first grid plate groups are provided on the surface of the bottom plate, a group of third slide rails are fixedly connected to both sides of the surface of the bottom plate below the first grid plate group, a pumping box is slidably connected between the third slide rails, a pumping pipe is connected through one side of the bottom of the pumping box, the pumping pipe is connected to a dehumidification pump through a pipeline, and a switch valve is installed on the pumping pipe;

[0018] A second grid plate group is arranged below the first grid plate group, and the first grid plate group and the second grid plate group can be plugged in. The bottom surface of the second grid plate group is fixedly connected to a connecting plate, and the two sides of the connecting plate are fixedly connected to a second telescopic part. The second data processing end is connected to the first pump body, the one-way valve, the sterilization lamp, the liquid pump, the control valve, the dehumidification pump, the switch valve, and the second telescopic part signal.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] By setting up a transfer lifting part, a first clamping part, a second clamping part, a suction part, an infection monitoring part, a sterilization lamp and an atomization part, on the one hand, the intelligent clamping and loading and unloading processes of the medicine packaging box are realized; on the other hand, with the help of the internal settings of the infection monitoring part, the infection situation on the surface of the packaging box is monitored, and the infection prediction coefficient is determined according to the environmental humidity and the amount of debris particles, so as to judge the degree of infection, and take corresponding supplementary sterilization measures according to the obtained degree of infection, so as to improve the sterilization effect and ensure the sterilization of the box during transportation. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0022] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0023] Figure 2 Schematic diagram of the structure of the first atomization part of the present invention;

[0024] Figure 3 This invention Figure 1 Schematic diagram of the top view structure;

[0025] Figure 4 It is a structural schematic diagram of the transfer lifting part of the present invention;

[0026] Figure 5 This invention Figure 4 A schematic diagram of the enlarged structure of region A;

[0027] Figure 6 Schematic diagram of the external structure of the infection monitoring unit of the present invention;

[0028] Figure 7 This invention Figure 6 Schematic diagram of the partial cross-section structure;

[0029] Figure 8 This invention Figure 7 Schematic diagram of the structure viewed from above;

[0030] Figure 9 It is a schematic diagram of the R region of the present invention;

[0031] Figure 10 Schematic diagram of the structure of the sterilization tube of the present invention;

[0032] Figure 11 It is a schematic diagram of the connection of the liquid storage tank pipeline of the present invention;

[0033] Figure 12 It is a schematic diagram of the bottom plate structure of the present invention;

[0034] Figure 13 This invention Figure 12 Schematic diagram of the top view structure;

[0035] Figure 14 This invention Figure 12 Schematic diagram of the side section structure;

[0036] Figure 15 This invention Figure 14 A magnified schematic diagram of the B region structure;

[0037] Figure 16 This invention Figure 14 Schematic diagram of the closed state;

[0038] Figure 17 This invention Figure 14 A magnified schematic diagram of the C region structure;

[0039] In the figure: 1, box body; 2, box door; 3, first driving part; 4, bottom plate; 5, first connecting frame; 6, first moving part; 7, first slide; 8, first pump body; 9, sterilization lamp; 10, first atomization part; 11, liquid storage tank; 12, first scanning part; 13, transport lifting part; 14, lifting frame; 15, infection monitoring part; 151, air inlet pipe; 152, air outlet pipe; 153, compartment; 154, second driving part; 155, display board; 156, scraping part; 157, chute; 158, slide; 159, second scanning part; 16, Second connecting frame; 17. Third driving part; 18. Conveyor belt; 19. Fixed block; 20. Support part; 21. Connecting block; 22. L-shaped block; 23. Second slider; 24. Second slide rail; 25. First clamping part; 26. Push block; 27. Second clamping part; 28. First telescopic part; 29. Suction part; 30. Flow-through part; 31. Sterilization tube; 32. Control valve; 33. Third slide rail; 34. Pumping box; 35. Pumping tube; 36. Switch valve; 37. First grid plate group; 38. Connecting plate; 39. Second grid plate group; 40. Second telescopic part. DETAILED DESCRIPTION

[0040] EXAMPLES Preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present invention and are not used to limit the present invention.

[0041] Example: Figure 1-Figure 5 As shown, the present invention provides a sterile transport device for freeze-dried drugs for injection, comprising a box 1, which is a packaging box for transporting and storing freeze-dried drugs for injection, hereinafter referred to as a packaging box. The box 1 is in a cubic shape and has a storage cavity inside, which is convenient for stacking the packaging boxes. A set of box doors 2 are rotatably mounted on the surface of each side of the box 1 opposite to the storage cavity. The number of the two box doors in a set is set to two. By changing the rotation state, the box doors 2 are closed and opened, respectively, for transport, storage, and loading and unloading processes. The box door 2 is connected to the top of one side of the box 1 and is connected to a first driving part 3 through a rod transmission, which is used to drive the rotation of the box door 2.

[0042] In addition, it is noted that rollers are installed around the bottom of the box 1 for moving the box 1 to the corresponding loading and unloading location; a hand-push or electric control mode can be used, which will not be described in detail here; Figure 1As shown, a position sensor is provided at the loading and unloading location to determine the loading and unloading position of the box 1 and ensure the accuracy of the loading and unloading position.

[0043] A bottom plate 4 is installed at the bottom of the storage cavity in the box body 1. The bottom plate 4 can be connected by plugging, snapping, threading, etc. The upper surface of the bottom plate 4 is used to support the packaging box; among them, a linear array stacking method is preferably used.

[0044] A first movable portion 6 is fixedly connected to the inner wall of the other side surface of the box body 1 opposite to the storage cavity. The first movable portion 6 can be configured as a linear motor or a screw-nut mechanism that moves up and down. The first movable portion 6 includes a first slide rail, and a first slider 7 is fixedly connected to the moving output end of the first slide rail.

[0045] like Figure 2 As shown, the top of the first slider 7 is fixedly connected to a horizontally placed first connecting frame 5, and the first connecting frame 5 is a U-shaped structure. The first connecting frame 5 is fixedly connected to the first pump body 8 near the top of the first slider 7. The input end of the first pump body 8 is connected to a liquid storage tank 11 through a pipeline. A one-way valve is installed on the pipeline. The liquid storage tank 11 stores a sterilizing liquid; the sterilizing liquid stock solution can be but is not limited to peracetic acid, ethanol, and quaternary ammonium salt disinfectant. By mixing with water in a certain proportion, a sterilizing liquid is formed to perform sterilization treatment, thereby improving the sterility of the transportation environment;

[0046] Furthermore, a plurality of first atomizing parts 10 are installed through the surface of the first connecting frame 5. The first atomizing parts 10 can be configured as an atomizer structure. The sterilizing liquid is in an atomized state when spraying. On the one hand, it expands the sterilization coverage and has a longer suspension time. On the other hand, it reduces liquid residue and reduces the damage to the surface of the packaging box.

[0047] Several first atomization parts 10 are connected to the output end of the first pump body 8. When the first pump body 8 is started, the one-way valve opens. According to its set operating power, the sterilization liquid enters the first connecting frame 5 through the pipeline and is sprayed out through the first atomization part 10 to carry out the sterilization process of the packaging box during shipment.

[0048] A sterilization lamp 9 is fixedly installed below the first connecting frame 5 for performing ultraviolet disinfection on the surface of the packaging box.

[0049] like Figure 4 、 Figure 5As shown, a transfer lifting portion 13 is correspondingly provided on the outer side of the box door 2 at the loading and unloading location. Referring to the setting of the manipulator, the transfer lifting portion 13 is composed of a telescopic rod and a rotary motor, which can adjust the height of different positions of the output end and realize different angles of rotation at the corresponding height. The details are not described here. The output end of the transfer lifting portion 13 is fixedly connected to a support rod, and a lifting frame 14 is fixedly installed at the bottom of the support rod. The lifting frame 14 is welded by multiple trusses.

[0050] When the transfer lifting part 13 places the packaging box into the storage cavity of the box body 1, the lifting frame 14 is fixedly connected to the middle of the frame body on one side close to the box body 1, and a second clamping part 27 is provided below the first clamping part 25. Specifically, the lifting frame 14 is fixed with a first telescopic part 28 above the middle of the first clamping part 25, and the downward output end of the first telescopic part 28 is fixedly connected to the first clamping part 25. The first clamping part 25 is evenly penetrated and fixedly connected with a suction Part 29, the bottom height of the suction part 29 is consistent with the bottom height of the first clamping part 25, the suction part 29 adopts a tubular structure, and the diameter of the lower end of the suction part 29 is not less than the diameter of the middle and upper end of the suction part 29, and the outer surface of the middle and upper end of the suction part 29 passes through and is slidably connected to the frame body of the lifting frame 14; the first clamping part 25 and the bottom surface of the suction part 29 are directly in contact with the upper surface of the packaging box, and the second clamping part 27 is in contact with the lower surface of the packaging box to achieve upper and lower clamping of the packaging box.

[0051] The lifting frame 14 is also provided with a pushing assembly for pushing and stacking the packaging boxes. The pushing assembly includes a third driving part 17 fixed to the lifting frame 14, and the third driving part 17 is arranged on the side of the lifting frame 14 away from the first telescopic part 28. The output end of the third driving part 17 is connected to the conveyor belt 18 in a transmission manner. The other end of the conveyor belt 18 is supported and connected to the support part 20. The support part 20 includes a gear and an ear seat connected to the middle bearing of the gear. The ear seat is fixed to the frame body of the lifting frame 14. The gear and the conveyor belt 18 are connected by a meshing transmission. A fixed block 19 is fixedly connected to the surface of the conveyor belt 18, and a connecting block 21 is fixedly connected to the bottom surface of the fixed block 19. An L-shaped block 22 is fixedly connected to the bottom surface of the connecting block 21. At least one set of second sliders 23 are fixedly connected to the upper surface of the L-shaped block 22 facing the upper surface of the lifting frame 14. A second slide rail 24 is fixedly connected to the position of the bottom of the lifting frame 14 corresponding to the second slider 23. The second slide rail 24 is slidably connected to the second slider 23 to ensure the movement stability of the second clamping portion 27; a push block 26 is fixedly connected to the end of the second slide rail 24 close to the first clamping portion 25;

[0052] A data receiving end is provided on the outside of the box body 1 or the transfer lifting part 13, a first data processing end is provided at the transfer lifting part 13, and a second data processing end is provided on the box body 1. The data receiving end is signal-connected with the first data processing end and the second data processing end, and is used to receive and analyze the received monitoring data, and output corresponding execution instructions to the corresponding data processing end to complete the sterile transfer process.

[0053] In this embodiment, the first data processing end is signal-connected to the transfer lifting part 13, the third driving part 17, and the first telescopic part 28, and executes the loading and unloading process of the packaging box through a pre-set program.

[0054] Specifically, when the box body 1 moves to the set loading location, the box door 2 remains in the open state, wherein the number of the box doors 2 on both sides that are opened is related to the number of packaging boxes placed. For the position where the box door 2 is opened, the transfer lifting part 13 drives the lifting frame 14 to move and rotate to the packaging box loading point. The packaging box loading point can be placed by manual handling or by intelligent loading method, so that the packaging box can be clamped and unloaded during the transfer process; the intelligent loading method is that the lifting frame 14 moves to the side of the packaging box to be clamped under program control, the second clamping part 27 maintains the longest extended state, and the downward output end of the first telescopic part 28 controls the first clamping part 25 to be in the retracted state. Thereafter, the lifting frame 14 contacts the packaging box to the lower surface of the packaging box under the drive of the transfer lifting part 13, and the downward output end of the first telescopic part 28 controls the first clamping part 25 to move down to the extended state, so that the lifting frame 14 clamps the packaging box;

[0055] Then it moves to the unloading point of the packaging box set on the bottom plate 4 to unload. Specifically, when unloading, the suction part 29 maintains the suction state and applies suction force to the upper surface of the packaging box. When the packaging box is above the unloading point, the pushing component is started, that is, the third driving part 17 is started to Figure 4 For example, the conveyor belt 18 is driven in a clockwise direction, and the conveyor belt 18 drives the second clamping part 27 to retract through the connected fixed block 19, the connecting block 21, and the L-shaped block 22. Under the blocking action of the push block 26, until the second clamping part 27 is no longer in contact with the packaging box, at a preset height, the first telescopic part 28 drives the first clamping part 25 and the suction part 29 to move downward. After being placed stably at the bottom of the packaging box, the suction part 29 stops sucking, and the first telescopic part 28 returns to the retracted state, thereby completing the loading and unloading process of the packaging box.

[0056] During the loading process, the sterilization lamp 9 is used as needed. In addition, the first movable part 6 can be adjusted in height synchronously according to the height of the package box during loading. During the unloading process of the package box, the sterilization lamp 9 can sterilize the package box from bottom to top with the maximum irradiation area. After the package box is placed stably, the sterilization lamp 9 remains at a position not lower than the height of the upper surface of the package box and prepares for irradiation and sterilization of the next package box.

[0057] like Figure 6-Figure 8 As shown, an infection monitoring unit 15 is mounted on the surface of the support rod above the lifting frame 14. The back of the infection monitoring unit 15 is fixedly connected to a second connecting frame 16, which is fixedly mounted on the support rod to complete the fixed installation of the infection monitoring unit 15.

[0058] like Figure 6 As shown, the side wall of the infection monitoring unit 15 is connected to an air inlet pipe 151, a humidity detector is installed at the air inlet pipe 151, and the top of the infection monitoring unit 15 is connected to an air outlet pipe 152. Figure 7 As shown, a compartment 153 is provided at the upper portion of the infection monitoring portion 15, and a monitoring chamber is provided in the middle portion thereof. A dust collecting pump is provided in the compartment 153 at the lower end of the air outlet pipe 152. The input end of the dust collecting pump passes through the bottom of the compartment 153 through a pipe and communicates with the monitoring chamber. The monitoring chamber is communicated with the air inlet pipe 151. The above-mentioned suction portions 29 are all connected to the air inlet pipe 151. The dust collecting pump can provide the suction force required by the suction portion 29.

[0059] like Figure 8 As shown, the monitoring chamber is provided with a second scanning unit 159 and a display panel 155 on both sides along the airflow direction; Figure 9 As shown, the scanning area of the second scanning unit 159 is marked as R. The second scanning unit 159 determines the debris particle ratio by photographing the area occupied by the debris particles in the R area, which is marked as r. i , i is the serial number of the clamped packaging box, and the maximum proportion coefficient of the allowed debris particles is pre-set to r max During the period when the first telescopic portion 28 controls the first clamping portion 25 to move downward to the extended state, the dust collection pump is started and absorbs the ambient air near the packaging box. After the clamping is completed, the suction process is suspended, and then the debris particle ratio coefficient is obtained.

[0060] In this embodiment, the first data processing terminal is also connected to the dust collection pump, the second scanning unit 159, and the humidity detector signal to monitor the contamination of the particles on the surface of the packaging box and establish an infection prediction coefficient Ψ to indicate the degree of contamination;

[0061]

[0062] in, It is determined by the ambient humidity and recorded as the environmental impact coefficient. The real-time humidity measured by the humidity detector is recorded as Si, and the maximum humidity that the freeze-dried drug can adapt to the environment is recorded as Smax. It should be noted that the humidity of the transportation environment in most warehouses or workshops is controllable, but there are also phenomena where the ambient humidity cannot be macro-controlled. Therefore, the environmental impact coefficient is established. ; When Si≤Smax, Take 1, the environment is in normal humidity state; when Si>Smax, If -1 is selected, the environment is in a high humidity state;

[0063] Therefore, the infection prediction coefficient Ψ is determined by the environmental impact coefficient and the debris particle ratio coefficient. The first data processing end transmits the infection prediction coefficient to the data receiving end. The data receiving end predicts the infection level on the surface of the packaging box based on the infection prediction coefficient, and transmits the treatment measures to the second data processing end. According to the obtained infection level, corresponding supplementary sterilization measures are taken to improve the sterility level during the transportation process.

[0064] Furthermore, a transparent cover is installed on the side of the scanning end of the second scanning unit 159 facing the inside of the monitoring cavity, preferably made of glass, to facilitate cleaning of debris particles on the scanning end; a lamp bead for brightening is installed in the middle of the display panel 155 to improve the clarity of the scanning results.

[0065] The monitoring chamber is further provided with a set of scraping parts 156 for cleaning the transparent shield and the surface of the display panel 155. The upper and lower ends of the scraping parts 156 are slidably connected to a slide 157, which is fixed to the inner wall of the monitoring chamber. A slide 158 is fixedly connected between the tops of the scraping parts 156. The middle part of the slide 158 is rotatably connected to a screw structure, one end of which is fixedly connected to the second drive part 154.

[0066] After completing the monitoring of the particles on the surface of the packaging box marked i, if If the value is lower than a preset comparison parameter, usually not higher than 0.5, the second drive unit 154 will not start; otherwise, the second drive unit 154 will start to perform the scraping process. When the airflow flows next time, the particles are extracted and separated from the airflow under the action of the dust collecting pump. For example, the compartment 153 is provided with a space for storing debris particles, and the airflow is discharged from the air outlet pipe 152. This is a conventional debris filtering and isolation process when the dust collecting pump is used, which will not be elaborated here. It is intended to achieve clean outflow of airflow and debris collection.

[0067] like Figure 10 As shown, a liquid pump is installed on the top of the storage chamber of the box body 1, and the liquid pump is connected to the flow part 30 through a pipeline. The flow part 30 is connected to the liquid storage tank 11 by a pipeline. A sterilization tube 31 is fixedly installed above the side wall of the storage chamber, and a plurality of second atomization parts are evenly installed on the surface of the sterilization tube 31 facing the inside of the storage chamber. The sterilization tube 31 and the flow part 30 are connected by a pipeline and a control valve 32 is provided on the pipeline to control the output state of the sterilization liquid.

[0068] like Figure 12-14As shown, the surface of the bottom plate 4 is provided with a plurality of first grid plate groups 37. The first grid plate group 37 is composed of a plurality of first grids arranged in an array with a certain gap. A group of third slide rails 33 are fixedly connected to both sides of the surface of the bottom plate 4 below the first grid plate group 37. A suction box 34 is slidably connected between the third slide rails 33. A suction pipe 35 is connected to the bottom side of the suction box 34 through a pipe. The suction pipe 35 is connected to a dehumidification pump through a pipeline. An on-off valve 36 is installed on the suction pipe 35 to control the connection state of the suction pipe 35.

[0069] Furthermore, a second grid plate group 39 is provided below the first grid plate group 37. The second grid plate group 39 is composed of a plurality of second grids arranged in an array with a certain gap, and the first grid plate group 37 can be completely plugged into the second grid plate group 39 to fill the gap, so that the bottom plate 4 has a flat and gapless upper surface; preferably, the positions of the first grid and the second grid are staggered, and the cross-section is a trapezoidal structure;

[0070] The bottom surface of the second grid plate group 39 is fixedly connected to the connecting plate 38, and the two sides of the connecting plate 38 are fixedly connected to the second telescopic portion 40. By the extension and contraction of the second telescopic portion 40, the first grid plate group 37 and the second grid plate group 39 switch the separation and closing states of the bottom plate 4; Figure 15 As shown, the bottom plate 4 is in a separated state, and the air flow containing the atomized sterilizing liquid in the box body 1 can be discharged from the suction pipe 35 through the gap between the first grid plate group 37 and the second grid plate group 39, as shown in FIG. Figure 16 、 Figure 17 As shown, the bottom plate 4 is in a closed state, and the air flow cannot flow out through the bottom plate 4.

[0071] In this embodiment, the second data processing end is signal-connected to the first pump body 8, the one-way valve, the sterilization lamp 9, the liquid pump, the control valve 32, the dehumidification pump, the switch valve 36, and the second telescopic part 40;

[0072] In addition, a first scanning unit 12 is fixedly connected to the top middle of the first connecting frame 5 for monitoring moisture on the surface of the packaging box during the sterilization process; it can be combined with the above-mentioned supplementary sterilization measures to ensure the normal storage state of the packaging box in the box body 1.

[0073] Specifically, a qualified infection coefficient ∂1 and a severe infection coefficient ∂2 are established, 0<∂1≤1, -1≤∂2<0, the qualified infection coefficient ∂1 is used to judge the degree of infection under normal environmental conditions, and the severe infection coefficient ∂2 is used to judge the degree of infection under high humidity environments;

[0074] When Ψ=0, it indicates that the environment has reached an ideal sterile environment and no additional sterilization measures are required. During the transportation of the packaging box, the sterilization lamp 9 is at the top of the box body 1 and lights up, performing routine sterilization on the box body 1, and the bottom plate 4 is in a closed state;

[0075] When 0<Ψ≤∂1, it indicates that the environmental humidity is normal and the infection level is low. During the transportation of the packaging box, the germicidal lamp 9 is at the top of the box body 1 and lights up. The sterilization pipe 31 sprays a fixed amount of atomized sterilization liquid downward to enhance the sterilization effect, which is reflected by the spraying time. The bottom plate 4 is in a separated state, and the dehumidification pump is started at the primary power to accelerate the flow of atomized molecules and improve the sterilization effect.

[0076] When Ψ>∂1, it indicates that the ambient humidity is normal and the infection level is high. During the transportation of the packaging box, the sterilization lamp 9 is at the top of the box body 1 and lights up. The sterilization pipe 31 sprays a second-level quantitative atomized sterilization liquid downward, where the second-level quantitative is higher than the first-level quantitative. The sterilization lamp 9 is at the top of the box body 1 and lights up. In addition, the bottom plate 4 is in a separated state, and the dehumidification pump is started at a high power level, further accelerating the flow and discharge of the atomized molecules, thereby improving the sterilization effect and preventing the atomized molecules from staying on the surface of the packaging box for too long, thereby accelerating the drying speed after sterilization.

[0077] When ∂2≤Ψ<0, it indicates a high humidity environment and a low infection level. A high humidity environment will reduce the sterilization effect of the sterilization lamp 1. Therefore, to ensure its sterilization effect, the sterilization lamp 9 is adjusted in height synchronously with the position of the packaging box at the loading point; the sterilization pipe 31 stops spraying the sterilization liquid to avoid excessive increase in ambient humidity. In addition, the first pump body 8 is started at the primary power, and the first atomization part 10 accurately achieves enhanced sterilization of the packaging box surface by following the operation of the sterilization lamp 9. The bottom plate 4 is in a separated state, and the dehumidification pump is started at the primary power.

[0078] When Ψ<∂2, it means that the environment is in high humidity and the degree of infection is high. Therefore, the sterilization lamp 9 adjusts its height synchronously with the position of the packaging box at the loading point, the sterilization pipe 31 stops spraying the sterilization liquid, the first pump body 8 is started at high power, the bottom plate 4 is in a separated state, and the dehumidification pump is started at high power to improve the sterilization effect.

[0079] In addition, when the first pump body 8 is started, the first scanning unit 12 monitors the moisture phenomenon on the surface of the packaging box. That is, after the sterilization liquid is sprayed, the first scanning unit 12 obtains the moisture points on the surface of the packaging box that can be measured. If there are moisture points, the second data processing end will transmit the moisture data to the data receiving end and perform alarm processing to prevent the packaging box from getting damp and rotting, which will affect the medicines.

[0080] According to the above-mentioned method for using the sterile transport device for freeze-dried injection drugs, the specific contents are as follows:

[0081] S1: Box 1 moves to the set loading location and clamps the packaging box;

[0082] S2: When the first telescopic portion 28 controls the first clamping portion 25 to move downward, the dust collection pump is started, and the first data processing end monitors the infection status of the particles and debris on the surface of the packaging box and establishes an infection prediction coefficient;

[0083] S3: The first data processing end transmits the infection prediction coefficient to the data receiving end. The data receiving end predicts the infection level of the packaging box surface based on the infection prediction coefficient and transmits the treatment measures to the second data processing end.

[0084] S4: After the lifting frame 14 completes clamping the packaging box, it moves to the unloading point for unloading;

[0085] S5: During unloading, the second data processing terminal performs corresponding supplementary sterilization measures according to the obtained infection degree, so as to improve the sterilization effect and ensure the aseptic transportation of the box 1.

[0086] In the description of the present invention, it should be understood that the terms "up", "down", "front", "back", "left", "right", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings, and are only used to facilitate the description of the present invention, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as a limitation on the present invention.

[0087] Finally, it should be noted that the above embodiments are intended only to illustrate the technical solutions of the present invention and are not intended to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will appreciate that modifications may be made to the technical solutions described in the aforementioned embodiments, or that some of the technical features may be replaced with equivalents. Such modifications or replacements do not deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A sterile transport device for freeze-dried drugs for injection, comprising a box body (1), the interior of the box body (1) being configured as a storage cavity, and a set of box doors (2) being rotatably mounted on the surface of each side of the box body (1) opposite to the storage cavity, characterized in that: A bottom plate (4) is installed at the bottom of the storage cavity, and a first moving part (6) is fixedly connected to the inner wall of the other opposite side surface of the box body (1) at the storage cavity position, and a moving output end of the first moving part (6) is fixedly connected to a first connecting frame (5) placed horizontally, a sterilization lamp (9) is fixedly installed below the first connecting frame (5), and a first scanning part (12) is fixedly connected to the middle of the top of the first connecting frame (5), and a liquid storage tank (11) is provided on the top of the box body (1), and a sterilization liquid is stored in the liquid storage tank (11); A transfer lifting portion (13) is provided on the outer side of the box door (2), the output end of the transfer lifting portion (13) is fixedly connected to a support rod, and a lifting frame (14) is fixedly installed on the bottom of the support rod. A first clamping portion (25) is fixedly connected to the middle of the lifting frame (14) on one side close to the box body (1), and a second clamping portion (27) is provided below the first clamping portion (25). A first telescopic portion (28) is fixed above the middle of the first clamping portion (25) on the lifting frame (14), and the downward output end of the first telescopic portion (28) is fixedly connected to the first clamping portion (25). A suction portion (29) is evenly penetrated and fixedly connected to the four sides of the first clamping portion (25); A data receiving terminal is provided on the outside of the box (1) or the transfer lifting part (13), a first data processing terminal is provided at the transfer lifting part (13), a second data processing terminal is provided on the box (1), an infection monitoring part (15) is installed on the surface of the support rod, an air inlet pipe (151) is connected to the side wall of the infection monitoring part (15), a humidity detector is installed at the air inlet pipe (151), an air outlet pipe (152) is connected to the top of the infection monitoring part (15), a partition (153) is provided on the upper part of the interior of the infection monitoring part (15), a monitoring chamber is provided in the middle part of the interior, a dust collecting pump is provided at the lower end of the air outlet pipe (152) in communication with the interior of the partition (153), the monitoring chamber is communicated with the air inlet pipe (151), the suction part (29) is connected to the air inlet pipe (151), and a second scanning part (159) and a display board (155) are provided on both sides of the monitoring chamber along the air flow direction.

2. The aseptic transport device for freeze-dried injection drugs according to claim 1, characterized in that: A first pump body (8) is fixedly connected to one side of the top of the first connecting frame (5); an input end of the first pump body (8) is connected to a liquid storage tank (11) via a pipeline; a plurality of first atomizing parts (10) are installed through the surface of the first connecting frame (5); and the plurality of first atomizing parts (10) are in communication with an output end of the first pump body (8).

3. The aseptic transport device for freeze-dried injection drugs according to claim 1, characterized in that: The bottom height of the suction portion (29) is consistent with the bottom height of the first clamping portion (25), and the diameter of the lower end of the suction portion (29) is not less than the diameter of the middle and upper end of the suction portion (29). The outer surface of the middle and upper end of the suction portion (29) passes through and is slidably connected to the frame body of the lifting frame (14).

4. The aseptic transport device for freeze-dried injection drugs according to claim 1, characterized in that: The lifting frame (14) is also provided with a pushing assembly, which includes a third driving part (17) fixed on the lifting frame (14), the output end of the third driving part (17) is connected to a conveyor belt (18), the other end of the conveyor belt (18) is supported and connected to a supporting part (20), the surface of the conveyor belt (18) located below is fixedly connected to a fixed block (19), the bottom surface of the fixed block (19) is fixedly connected to a connecting block (21), and the bottom surface of the connecting block (21) is fixedly connected to an L-shaped block (22).

5. The aseptic transport device for freeze-dried injection drugs according to claim 4, characterized in that: The L-shaped block (22) is fixedly connected to the upper surface of the lifting frame (14) with at least one set of second sliders (23), and the bottom of the lifting frame (14) is fixedly connected to a second slide rail (24) at a position corresponding to the second slider (23). The second slide rail (24) is slidably connected to the second slider (23), and the second slide rail (24) is fixedly connected to one end of the second slide rail (24) close to the first clamping portion (25). A push block (26) is fixedly connected.

6. The sterile transport device for freeze-dried drugs for injection according to claim 2, characterized in that: The first data processing end is connected to the dust collection pump, the second scanning unit (159), and the humidity detector signal to monitor the infection status of the particle debris on the surface of the packaging box and establish an infection prediction coefficient Ψ to represent the degree of infection; ,in, The environmental humidity is determined and recorded as the environmental influence coefficient. The scanning area of the second scanning unit (159) is recorded as R. The second scanning unit (159) determines the debris particle ratio coefficient by photographing the area occupied by the debris particles in the R area, which is recorded as r. i , the maximum allowable proportion of debris particles is pre-set to r max , i is the serial number of the clamped packaging box.

7. The aseptic transport device for freeze-dried injection drugs according to claim 6, characterized in that: A liquid pump is installed on the top of the storage chamber of the box body (1), and the liquid pump is connected to a flow portion (30) through a pipeline. The flow portion (30) is connected to the liquid storage box (11) through a pipeline. A sterilization tube (31) is fixedly installed above the side wall of the storage chamber. A plurality of second atomization parts are evenly installed on the surface of the sterilization tube (31) facing the inside of the storage chamber. The sterilization tube (31) and the flow portion (30) are connected by a pipeline, and a control valve (32) is provided on the pipeline.

8. The aseptic transport device for freeze-dried injection drugs according to claim 7, characterized in that: A plurality of first grid plate groups (37) are provided on the surface of the bottom plate (4); a group of third slide rails (33) are fixedly connected to both sides of the surface of the bottom plate (4) below the first grid plate group (37); a pumping box (34) is slidably connected between the third slide rails (33); a pumping pipe (35) is connected through one side of the bottom of the pumping box (34); the pumping pipe (35) is connected to a dehumidification pump through a pipeline; and a switch valve (36) is installed on the pumping pipe (35); A second grid plate group (39) is provided below the first grid plate group (37). The first grid plate group (37) and the second grid plate group (39) can be plugged into each other. A connecting plate (38) is fixedly connected to the bottom surface of the second grid plate group (39). A second telescopic portion (40) is fixedly connected to both sides of the connecting plate (38). The second data processing end is signal-connected to the first pump body (8), the one-way valve, the sterilization lamp (9), the liquid pump, the control valve (32), the dehumidification pump, the switch valve (36), and the second telescopic portion (40).

9. The aseptic transport device for freeze-dried injection drugs according to claim 6, characterized in that: A transparent shield is installed on the side of the scanning end of the second scanning part (159) facing the inside of the monitoring chamber, a lamp bead is installed in the middle of the display panel (155), and a group of scraping parts (156) are also provided inside the monitoring chamber, and the scraping parts (156) are transmission-connected to the second driving part (154).

10. The method for using the sterile transport device for freeze-dried injection drugs according to claim 8, characterized in that: Here’s how: S1: The box (1) moves to the designated loading location and clamps the packaging box; S2: When the first telescopic portion (28) controls the first clamping portion (25) to move downward, the dust collection pump is started, and the first data processing end monitors the infection status of the particles and debris on the surface of the packaging box and establishes an infection prediction coefficient; S3: The first data processing end transmits the infection prediction coefficient to the data receiving end. The data receiving end predicts the infection level of the packaging box surface based on the infection prediction coefficient and transmits the treatment measures to the second data processing end. S4: After the lifting frame (14) completes the clamping of the packaging box, it moves to the unloading point for unloading; S5: During unloading, the second data processing terminal performs corresponding supplementary sterilization measures according to the obtained infection degree, thereby improving the sterilization effect and ensuring the aseptic transportation of the box (1).

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