Anti-aging composition and application thereof

Abstract

The invention relates to the field of daily chemical health care, in particular to a composition for delaying senescence, which contains coenzyme, flavonoid and cubilose peptide. The cubilose peptide added in the formula can reduce nausea, vomiting and other side effects possibly caused by PQQ and dihydroquercetin, and glutathione yeast is added to promote digestion and absorption and improve the absorption effect of the whole formula.

Description

Technical Field

[0001] The invention relates to the field of daily chemical health care, and in particular to an anti-aging composition and application thereof. Background Art

[0002] Human aging refers to the various physiological, metabolic and functional changes that occur gradually in various systems, organs and tissues of the body after they grow, develop and mature. With age, human cells, especially skin cells, gradually age due to their own characteristics and the influence of the external environment, resulting in skin problems such as reduced skin fullness and elasticity, increased wrinkles, sagging and aging skin, pigmentation, dullness, etc. In addition, digestion ability and sleep quality will also be affected with age.

[0003] At present, there are many ingredients used for anti-aging, such as PQQ and quercetin. Among them, quercetin belongs to flavonoids, which is a kind of polyphenolic compound widely distributed in the plant kingdom (mainly in the leaves, flowers, roots, stems and fruits of plants). Its structure contains phenolic hydroxyl groups, which can react with free radicals to generate stable semiquinone free radicals, thereby effectively removing free radicals and achieving antioxidant effects; it also has many protective mechanisms for the cardiovascular system, such as reducing blood lipid content, inhibiting LDL oxidation, inhibiting platelet aggregation, reducing capillary permeability and fragility, etc.; flavonoids such as tea polyphenols and soy isoflavones also have the effect of inhibiting tumors. PQQ belongs to coenzymes, which is a general term for a large class of organic cofactors and is an essential factor for enzyme-catalyzed redox reactions, group transfer and isomerization reactions.

[0004] However, the inventors found in their research that although anti-aging ingredients such as PQQ and quercetin have outstanding effects, long-term use as health products, functional drinks, etc. may cause discomfort reactions such as nausea, vomiting, and indigestion. In addition, some users have a decline in digestive function due to aging, which leads to poor absorption of active ingredients, affecting the final anti-aging effect. Therefore, how to reduce these side effects while maintaining or improving the anti-aging effect is still a technical problem that needs to be solved in this field. Summary of the invention

[0005] The inventors, based on a large number of experiments, provide a composition for delaying aging, which has little side effects and good anti-aging effects.

[0006] The technical solution of the present invention is as follows:

[0007] A composition comprising coenzymes, flavonoids and bird's nest peptides.

[0008] In some embodiments, the coenzyme is selected from at least one of glutathione or its derivatives, adenosine triphosphate and its derivatives, pyrroloquinoline quinone or its derivatives, adenosine methionine or its derivatives, coenzyme A or its derivatives, and coenzyme Q or its derivatives, preferably pyrroloquinoline quinone and / or coenzyme Q10.

[0009] In some embodiments, the flavonoid is selected from one or more of quercetin, dihydroquercetin, fisetin, catechin, gallin, resveratrol, hesperetin, preferably quercetin and / or dihydroquercetin.

[0010] In some specific embodiments, the weight ratio of coenzyme, flavonoid and bird's nest peptide is (5-15): (0.05-0.015): (10-25), preferably 10:0.09:15.

[0011] In some embodiments, the composition further comprises glutathione yeast.

[0012] In some specific embodiments, the weight ratio of coenzyme, flavonoid, bird's nest peptide, and glutathione yeast is (5-15): (0.05-0.015): (10-25): (0.3-1), preferably 10: 0.09: 15: 0.5.

[0013] In some embodiments, the composition further contains complex vitamins and / or complex minerals, preferably complex vitamins and complex minerals.

[0014] In some specific embodiments, the compound vitamin is selected from one or more of L-ascorbic acid, dl-α-tocopherol acetate, riboflavin, niacin, vitamin A acetate, D-calcium pantothenate, pyridoxine hydrochloride, thiamine hydrochloride, folic acid, vitamin D3, and cyanocobalamin.

[0015] In some specific embodiments, the complex mineral is selected from one or more of calcium hydrogen phosphate, magnesium carbonate, zinc gluconate, and ferric pyrophosphate.

[0016] The invention also provides an edible composition for delaying aging, which comprises the composition described above.

[0017] In some embodiments, the edible composition further contains a food-acceptable excipient, wherein the excipient has any of the following characteristics:

[0018] 1) containing flavoring agents, wherein the flavoring agents are selected from one or more of oligofructose, lactose, stevioside, xylitol, honey, syrup, mint oil, instant tea powder, fruit juice powder, edible flavors, and citric acid;

[0019] 2) Containing dosage form excipients, wherein the dosage form excipients are selected from one or more of maltodextrin, calcium stearate, magnesium stearate, hydroxypropyl methylcellulose, microcrystalline cellulose, and silicon dioxide.

[0020] The invention also provides the use of the above-mentioned compound composition in the preparation of the following products:

[0021] (1) Anti-aging products;

[0022] (2) Products that improve sleep;

[0023] (3) Products that enhance immunity;

[0024] (4) Antioxidant products.

[0025] In practical applications, the product is one or more of solid beverages, liquid beverages, dairy products, seasoning powders, nutritional products, and oral health care products.

[0026] The beneficial effects of the present invention are:

[0027] 1. The bird's nest peptide added to the formula can reduce the side effects such as nausea and vomiting that may be caused by PQQ and dihydroquercetin, while increasing glutathione yeast to promote digestion and absorption, and improve the absorption effect of the entire formula.

[0028] 2. The ingredients of the composition are reasonably matched, which can synergistically fight against aging from many aspects such as improving skin quality, anti-oxidation, promoting sleep, and enhancing immunity. DETAILED DESCRIPTION

[0029] The present invention is further described below by way of examples, but the present invention is not limited to the scope of the examples. The experimental methods in the following examples without specifying specific conditions are carried out according to conventional methods and conditions, or selected according to the product specifications.

[0030] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

[0031] Example

[0032] Example 1 Composition of the invention

[0033] Formula 1: The ingredients and their weight ratios of the composition are:

[0034] PQQ: 10 parts

[0035] Dihydroquercetin: 0.09 parts

[0036] Bird's nest peptide: 15 servings

[0037] Glutathione yeast: 0.5 parts

[0038] Formula 2: The ingredients and their weight ratios of the composition are:

[0039] PQQ: 10 parts

[0040] Dihydroquercetin: 0.09 parts

[0041] Bird's nest peptide: 15 servings

[0042] Glutathione yeast: 0.5 parts

[0043] Vitamin complex: 15 servings

[0044] Compound minerals: 100 parts

[0045] Example 2 Human body verification of the anti-aging effect of the composition of the invention

[0046] 2.1 Experimental Grouping:

[0047] The proportion of each ingredient is shown in Table 2.1. Add auxiliary materials to make up to 5g. Each portion contains 200mg of active ingredient. Use 300ml of purified water to brew and then take.

[0048] Table 2.1

[0049]

[0050] 2.2 Experimental methods:

[0051] Subject grouping: 50 volunteers were randomly divided into 10 experimental groups, with 5 volunteers in each group, aged 31-53 years old. They can complete the evaluation work as required and truly and objectively reflect their feelings after use.

[0052] Usage: Each group of volunteers took it separately, once a day, 1 serving each time, for 5 consecutive days, and then rested for 2 days, for two consecutive cycles, a total of 14 days.

[0053] The scoring criteria are: very satisfied (5 points) (the test results improved by more than 20% compared to before the test); satisfied (3-4 points) (the test results improved by 10-20% compared to before the test); average (1-2 points) (the test results improved by 0-10% compared to before the test); and dissatisfied (0 point) (no improvement in the test results compared to before the test).

[0054] 2.3 Experimental results:

[0055] The results showed that compared with the blank group, experimental groups 1-3 showed significant improvements in skin smoothness and sleep levels. On this basis, the addition of bird's nest peptides and glutathione yeast further enhanced the anti-aging effect. Glutathione yeast can promote the absorption of nutrients and assist other ingredients in exerting their effects.

[0056] Table 2.2

[0057]

[0058] Example 3 Verification of the improvement of side effects of the composition of the invention

[0059] 3.1 Experimental methods:

[0060] The volunteers in the blank group, experimental group 2 (as the control group) and experimental groups 4-9 in Example 2 continued to take the composition of the invention, once a day, 1 serving each time, for 5 consecutive days, 2 days of suspension, two consecutive cycles, 2 cycles in the example, a total of 4 cycles, a total of 28 days. Fill in the scoring table according to the discomfort symptoms after taking it.

[0061] 3.2 Scoring criteria:

[0062] 5 points (no discomfort symptoms after taking the medicine), 3-4 points (mild indigestion symptoms, which are relieved after stopping taking the medicine), generally 1-2 points (symptoms such as indigestion and belching exist, which will continue for a period of time after stopping taking the medicine), 0 points (indigestion, belching, regurgitation, nausea and other discomfort symptoms occur).

[0063] 3.3 Experimental results:

[0064] The results showed that compared with the blank group, the control group (i.e., experimental group 2) experienced discomfort symptoms such as indigestion and belching after long-term use. After adding bird's nest peptide (experimental groups 4-6), the discomfort symptoms of the users were significantly reduced, and the relationship was dose-dependent, but after reaching a certain dose, the effect remained at a plateau. On this basis, glutathione yeast was further added to enhance the absorption effect, but no side effects were increased.

[0065] Table 3.2

[0066]

Claims

1. A composition, characterized in that The composition contains coenzymes, flavonoids and bird's nest peptides.

2. The composition according to claim 1, characterized in that The coenzyme is selected from at least one of glutathione or its derivatives, adenosine triphosphate and its derivatives, pyrroloquinoline quinone or its derivatives, adenosine methionine or its derivatives, coenzyme A or its derivatives, and coenzyme Q or its derivatives, preferably pyrroloquinoline quinone and / or coenzyme Q10.

3. The composition according to any one of claims 1 to 2, characterized in that The flavonoids are selected from one or more of quercetin, dihydroquercetin, fisetin, catechin, gallin, resveratrol, and hesperetin, preferably quercetin and / or dihydroquercetin.

4. The composition according to any one of claims 1 to 3, characterized in that The weight ratio of coenzyme, flavonoid and bird's nest peptide is (5-15): (0, 05-0, 015): (10-25), preferably 10:0, 09:

15.

5. The composition according to any one of claims 1 to 4, characterized in that The composition also contains glutathione yeast.

6. The composition according to claim 5, characterized in that The weight ratio of coenzyme, flavonoid, bird's nest peptide and glutathione yeast is (5-15): (0, 05-0, 015): (10-25): (0, 3-1), preferably 10: 0, 09: 15：0、5。 7. The composition according to any one of claims 1 to 6, characterized in that The composition further contains complex vitamins and / or complex minerals, preferably complex vitamins and complex minerals.

8. The composition according to claim 7, characterized in that The compound vitamin is selected from one or more of L-ascorbic acid, dl-α-tocopherol acetate, riboflavin, niacin, vitamin A acetate, D-calcium pantothenate, pyridoxine hydrochloride, thiamine hydrochloride, folic acid, vitamin D3, and cyanocobalamin.

9. The composition according to claim 7, characterized in that The composite mineral is selected from one or more of calcium hydrogen phosphate, magnesium carbonate, zinc gluconate, and ferric pyrophosphate.

10. An edible composition for delaying aging, characterized in that: The invention comprises a composition according to any one of claims 1 to 9.

11. The edible composition according to claim 10, characterized in that The edible composition further comprises a food-friendly excipient, wherein the excipient has any of the following characteristics: 1) containing flavoring agents, wherein the flavoring agents are selected from one or more of oligofructose, lactose, stevioside, xylitol, honey, syrup, mint oil, instant tea powder, fruit juice powder, edible flavors, and citric acid; 2) Containing dosage form excipients, wherein the dosage form excipients are selected from one or more of maltodextrin, calcium stearate, magnesium stearate, hydroxypropyl methylcellulose, microcrystalline cellulose, and silicon dioxide.

12. Use of the composition according to any one of claims 1 to 9 in the preparation of the following products: (1) Anti-aging products; (2) Products that improve sleep; (3) Products that enhance immunity; (4) Antioxidant products.

13. The use according to claim 12, characterized in that The product is one or more of a solid beverage, a liquid beverage, a dairy product, a seasoning powder, a nutrient, and an oral health care product, preferably a solid beverage.

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