Nanofiber eye patch prepared based on electrostatic spinning technology

Abstract

The electrostatic spinning technology is adopted, and the nanofiber eye patch which is high in active matter concentration, good in application performance, good in biocompatibility, low in cost and free of any corrosion resistance is prepared. The eye patch is composed of a polycaprolactone fiber membrane and a polyvinyl alcohol fiber membrane. Due to the fact that the hydrophilic and hydrophobic properties of the two fiber membranes are different, a wettability gradient can be formed, essence is sucked from the outside to the inside, and meanwhile external particles are prevented from making contact with eye skin. The nano-fibers have small diameters, so that the nano-fibers can penetrate into gullies of the skin, the contact area with the skin is increased, and compared with a common non-woven fabric mask carrying essence, the nano-fiber mask has the advantage that the adhesion to the skin is improved. Meanwhile, the polyvinyl alcohol nanofiber membrane can be dissolved in water, and a local high-concentration environment with high permeability can be formed. And finally, all materials (polycaprolactone and polyvinyl alcohol) used in the invention are biodegradable, and cannot cause any damage to the environment.

Description

Technical Field

[0001] The invention belongs to the field of cosmetics, and in particular relates to a nanofiber eye patch prepared based on electrospinning technology. Background Art

[0002] Eyes are the fastest and most intuitive window for humans to contact the outside world, and people are paying more and more attention to eye protection. With the continuous development of science and technology and the medical beauty industry, the research and development of eye patches is endless. Traditional eye patch substrates are mainly made of non-woven fabrics, which are generally made of cheaper fibers such as polypropylene and polyester. Polypropylene and polyester fibers have poor hydrophilicity, which is not conducive to the adsorption of nutrient solution. Then a series of high-end substrates were developed, mainly made of fibers with good skin affinity such as cotton and silk. The combination of traditional fiber substrates and nutrient solution will have many problems in use, such as many active substances in the nutrient solution are easy to deteriorate in the solution. It is difficult to unfold in the state of adsorbing nutrient solution and accurately apply it on the user's face, affecting the user experience.

[0003] Nanofiber membranes prepared by electrospinning technology have the advantages of ultra-fine fibers and small pores, and have been successfully introduced into the cosmetics field to prepare nanofiber eye patches. However, there are relatively few products on the market, and the price is relatively expensive, so the cost performance needs to be further improved. Some researchers have also used marine fish collagen to add plant ingredients and then electrospun them. The resulting nanofiber membranes can quickly penetrate into the deep layers of the skin and achieve the effects of increasing skin moisture content and improving wrinkles. This also proves that nanofiber eye patches have important application prospects in the cosmetics field.

[0004] Therefore, the present invention adopts electrostatic spinning technology to prepare a nanofiber eye patch with high active substance concentration, good applicability, good biocompatibility, low cost and no antiseptic. The eye patch is composed of two parts, a polycaprolactone fiber membrane and a polyvinyl alcohol fiber membrane. Due to the different hydrophilic and hydrophobic properties of the two layers of fiber membranes, a wettability gradient will be formed, and the essence will be sucked from the outside to the inside while preventing particles from the outside from contacting the eye skin. And because the nanofiber has a smaller diameter, it can go deep into the ravines of the skin, increasing the area of ​​contact with the skin. Compared with the ordinary non-woven fabric mask carrying the essence, the nanofiber mask increases the applicability to the skin. At the same time, the polyvinyl alcohol nanofiber membrane will dissolve in water and can form a local high-concentration environment with high permeability. Finally, all materials used in the present invention (polycaprolactone, polyvinyl alcohol) are biodegradable and will not cause any damage to the environment. Summary of the invention

[0005] The purpose of the present invention is to prepare a nanofiber eye patch prepared based on electrospinning technology. In addition, the prepared nanofiber eye patch can achieve the function of unidirectional moisture conduction.

[0006] In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0007] A nanofiber eye patch prepared based on electrospinning technology, composed of two layers of nanofiber membranes: the inner layer is a polyvinyl alcohol fiber membrane; the outer layer is a polycaprolactone fiber membrane;

[0008] Furthermore, the materials used are biodegradable polycaprolactone and polyvinyl alcohol.

[0009] Furthermore, the preparation method includes the following steps: dissolving polycaprolactone in a mixed solvent of methanol and chloroform, and adjusting the corresponding voltage and flow rate to prepare the outer layer of the nanofiber membrane.

[0010] Furthermore, the preparation method of the fiber membrane is as follows: the polycaprolactone concentration is 16% to 20% (w / v); the spinning voltage is 14kV to 16kV; and the flow rate is 5mL / h to 6mL / h.

[0011] Furthermore, the preparation method of the fiber membrane is as follows: the concentration of polyvinyl alcohol is 12% to 20% (w / v); the spinning voltage is 15kV to 17kV; and the flow rate is 0.2mL / h to 0.3mL / h.

[0012] The above technical solutions have the following benefits:

[0013] (1) The eye patch has a unidirectional moisture conduction effect. PVA is a hydrophilic film, while PCL is a hydrophobic film. PCL is on the outer layer. When the essence is poured into the PCL part, the essence will flow toward the PVA nanofiber layer, forming a moisture gradient.

[0014] (2) The outer layer intercepts particles and prevents them from penetrating into the essence layer.

[0015] (3) Since biodegradable materials such as polycaprolactone and polyvinyl alcohol are selected, the prepared eye patch can be completely degraded and will not cause any burden to the environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings / schedules required for use in the embodiments or the description of the prior art.

[0017] Figure 1 This is a schematic diagram of the two-layer structure of the eye patch; DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention are described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] Example 1: Preparation of polycaprolactone nanofiber membrane

[0020] Weigh 4.8 g of polycaprolactone into a glass bottle, add a certain proportion of methanol and chloroform, stir to dissolve, set the voltage to 14 kV ~ 16 kV; the flow rate is 5 mL / h ~ 6 mL / h.

[0021] Example 2: Preparation of polyvinyl alcohol nanofiber membrane

[0022] Weigh 5.4 g of polyvinyl alcohol into a glass bottle, add water and stir to dissolve, set the voltage to 15 kV to 17 kV, and the flow rate to 0.2 mL / h to 0.3 mL / h.

Claims

1. A nanofiber eye patch prepared based on electrospinning technology, characterized in that: It consists of two layers of nanofiber membranes: the inner layer is polyvinyl alcohol fiber membrane; the outer layer is polycaprolactone fiber membrane.

2. The nanofiber eye patch prepared based on electrospinning technology according to claim 1, characterized in that: The materials used are biodegradable polycaprolactone and polyvinyl alcohol.

3. The nanofiber eye patch prepared based on electrospinning technology according to claim 1, characterized in that: The preparation method comprises the following steps: dissolving polycaprolactone in a mixed solvent of methanol and chloroform, and adjusting the corresponding voltage and flow rate to prepare the outer layer nanofiber membrane.

4. The nanofiber eye patch prepared based on electrospinning technology according to claim 3, characterized in that: The preparation method of the fiber membrane is as follows: the concentration of polycaprolactone is 16% to 20% (w / v); the spinning voltage is 14kV to 16kV; and the flow rate is 5mL / h to 6mL / h.

5. The nanofiber eye patch prepared based on electrospinning technology according to any one of claim 3, characterized in that: The concentration of polyvinyl alcohol is 12% to 20% (w / v); the spinning voltage is 15 kV to 17 kV; and the flow rate is 0.2 mL / h to 0.3 mL / h.

Images