Tooth-protecting toothpaste for removing berry stains and preparation method of tooth-protecting toothpaste

Abstract

The invention discloses a tooth-protecting toothpaste for removing berry stains and a preparation method thereof, and relates to the technical field of oral health, and the tooth-protecting toothpaste comprises the following components in parts by weight: 24-31 parts of a friction agent, 1-1.5 parts of a surfactant, 4.8-7.5 parts of a stain-removing active component, 0.8-1.7 parts of an enzyme component, 5.42-6.75 parts of a protecting component, 1-1.5 parts of an antioxidant component, 1.5-2.5 parts of a natural extract, 35-40 parts of a wetting agent and 0.2-0.5 part of a refreshing component. According to the toothpaste disclosed by the invention, through the synergistic effect of introduced stain-removing active components and enzyme components, the removal efficiency of berry stains is remarkably improved, and by adopting the innovative combination of nano-hydroxyapatite, strontium chloride, graphene oxide and sodium hyaluronate, not only can micropores and cracks on the surface of enamel be repaired, but also the surface of the enamel can be protected; a smooth protective film can be formed on the surface of teeth, so that acidic components of berry stains are prevented from eroding the teeth, and meanwhile, reattachment of pigments is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of oral health, in particular to a toothpaste for removing berry stains and a preparation method thereof. Background Art

[0002] Berry fruits (such as blueberries, raspberries, blackberries, etc.) are widely favored by consumers worldwide due to their rich nutrients and antioxidant effects. Berries are not only a common health food, but are also widely used in the preparation of various beverages, including berry juice, berry wine, etc. Although berries have many benefits for human health, the stubborn stains formed after their pigments are deposited on the surface of teeth, namely berry stains, have become a troubling problem. These stains not only affect the beauty of teeth, but may also cause a series of oral health problems. The formation of berry stains is mainly attributed to the large amount of natural polyphenols (such as anthocyanins, ellagic acid) and organic acids (such as citric acid and malic acid) rich in berries. Polyphenols are the main source of dark pigments and have strong chemical stability. They can react chemically with the protein film and mineralized components (such as hydroxyapatite) on the surface of teeth to form a strong complex. In addition, the organic acids in berries are corrosive and can accelerate the erosion of the enamel surface, providing more favorable conditions for pigment deposition. At the same time, berries also contain a certain amount of pectin, a sticky substance that not only increases the stability of pigment adhesion, but also places higher demands on cleaning methods. The presence of berry stains not only increases the roughness of the tooth surface, making it easier for pigments to deposit, but may also become a breeding ground for bacteria, further threatening oral health.

[0003] Compared with other types of stains (such as coffee stains, tea stains or smoke stains), the formation mechanism of berry stains is more complicated. This complexity is reflected in the following aspects: (1) The adhesion of the pectin matrix: The pectin in berries can bind to the tooth surface to form a protective film, making the pigment more difficult to remove. (2) The stability of the dark polyphenol complex: After the polyphenol compounds combine with the mineralized components on the tooth surface, they form a dark complex with high chemical stability, which increases the difficulty of cleaning. (3) The erosion of the acidic components: Organic acids can erode the surface of tooth enamel, expand the micropores and cracks of the teeth, and make it easier for pigments to penetrate and adhere deeply. These characteristics determine that berry stains are not only difficult to remove by ordinary cleaning methods, but also pose a potential threat to tooth and oral health. However, the common stain removal toothpastes on the market are mostly designed for the characteristics of coffee stains and tea stains, while there is a relative lack of specialized research and solutions for berry stains. This deficiency has caused many consumers to face the problem of being unable to effectively remove tooth stains after eating berries for a long time.

[0004] Traditional stain-removing toothpastes have the following main shortcomings when dealing with berry stains: (1) Limitations of high-hardness abrasives. Although abrasives (such as calcium carbonate, silica, etc.) can remove surface stains on teeth through physical friction, they are almost ineffective against deep pigments (such as pectin and polyphenol complexes). In addition, long-term use of high-hardness abrasives will cause irreversible damage to tooth enamel, making the tooth surface rough, thereby exacerbating the vicious cycle of pigment deposition. (2) Irritation of bleaching agents. Chemical bleaching agents (such as hydrogen peroxide or perborate) decompose pigment molecules through redox reactions. Although they can achieve a certain cleaning effect in the short term, they are highly irritating and may cause damage to tooth enamel and oral mucosa. In particular, long-term use can cause tooth sensitivity or oral discomfort. Therefore, this method is not suitable for daily use. (3) Lack of anti-reattachment ability. Ordinary stain-removing toothpastes usually lack effective protection mechanisms and it is difficult to prevent pigments from reattaching after cleaning. In particular, the polyphenol pigments and pectin matrix in berry stains are very easy to adhere to the surface of teeth. This characteristic makes it difficult for the cleaning effect of existing toothpaste to last long, and consumers need to use it frequently to keep their teeth clean. Summary of the invention

[0005] The purpose of this section is to summarize some aspects of embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the specification abstract and the invention title of this application to avoid blurring the purpose of this section, the specification abstract and the invention title, and such simplifications or omissions cannot be used to limit the scope of the present invention.

[0006] In view of the above and / or existing problems in existing toothpastes for removing berry stains, the present invention is proposed.

[0007] Therefore, the problem to be solved by the present invention is how to provide a toothpaste for removing berry stains.

[0008] In order to solve the above technical problems, the present invention provides the following technical solutions: a toothpaste for removing berry stains, comprising, by weight, 24 to 31 parts of abrasives, 1 to 1.5 parts of surfactants, 4.8 to 7.5 parts of stain removal active ingredients, 0.8 to 1.7 parts of enzyme components, 5.42 to 6.75 parts of protective components, 1 to 1.5 parts of antioxidant components, 1.5 to 2.5 parts of natural extracts, 35 to 40 parts of wetting agents, and 0.2 to 0.5 parts of freshening components; the stain removal active ingredients are sodium pyrophosphate, sodium citrate, polyaspartic acid and chitosan derivatives.

[0009] As a preferred embodiment of the toothpaste for removing berry stains of the present invention, the mass ratio of the sodium pyrophosphate, sodium citrate, polyaspartic acid and chitosan derivative is 1.5-2.5:2-3:1-1.5:0.3-0.5.

[0010] As a preferred embodiment of the toothpaste for removing berry stains of the present invention, the mass ratio of the sodium pyrophosphate, sodium citrate, polyaspartic acid and chitosan derivative is 2.3:2.6:1.3:0.35.

[0011] As a preferred embodiment of the toothpaste for removing berry stains of the present invention, the enzyme components are pectinase, papain and laccase, wherein the mass ratio of pectinase, papain and laccase is 0.5-1:0.2-0.4:0.1-0.3.

[0012] As a preferred embodiment of the toothpaste for removing berry stains according to the present invention, the protective ingredients are nano-hydroxyapatite, strontium chloride, graphene oxide and sodium hyaluronate, wherein the mass ratio of nano-hydroxyapatite, strontium chloride, graphene oxide and sodium hyaluronate is 5-6: 0.3-0.5: 0.02-0.05: 0.1-0.2.

[0013] As a preferred embodiment of the toothpaste for removing berry stains of the present invention, the abrasive is microcrystalline silicon dioxide and aluminum hydroxide, wherein the mass ratio of microcrystalline silicon dioxide to aluminum hydroxide is 20-25:4-6.

[0014] As a preferred embodiment of the toothpaste for removing berry stains according to the present invention, the natural extracts are blueberry extract and rosehip extract, wherein the mass ratio of the blueberry extract to the rosehip extract is 1-1.5:0.5-1.

[0015] As a preferred embodiment of the toothpaste for removing berry stains of the present invention, the surfactant is sodium lauroyl glutamate.

[0016] As a preferred embodiment of the toothpaste for removing berry stains of the present invention, the antioxidant component is L-ascorbic acid; the wetting agent is glycerol and water, wherein the mass ratio of glycerol to water is 20-22:15-18; and the refreshing component is peppermint oil.

[0017] The present invention also provides a method for preparing a toothpaste for removing berry stains, which comprises the following steps: step 1: adding glycerin and deionized water into a stirred reactor in proportion, stirring evenly to completely dissolve the glycerin to form a transparent and uniform base liquid, then slowly adding sodium lauroyl glutamate, continuing to stir until it is completely dissolved to form a stable liquid phase system;

[0018] Step 2: Pre-dissolve sodium pyrophosphate, sodium citrate and polyaspartic acid in a small amount of deionized water, and slowly add them to the base liquid in turn after dissolution, stirring at a low speed to form a stain removal active system; dissolve pectinase and laccase in warm water, and slowly add them to the base liquid after dissolution, stirring evenly, stirring at a low speed, and finally add papain;

[0019] Step 3: Disperse the nano-hydroxyapatite with deionized water and treat it with an ultrasonic disperser, then add the base liquid and stir evenly, dissolve the chitosan derivative in warm water, stir at a low speed until it is completely dissolved, and then add it to the stain removal active system to form a tooth enamel protective layer component, dissolve strontium chloride directly in a small amount of water and add it slowly, disperse graphene oxide with a high shear disperser, then add the base liquid at a low speed, gradually add microcrystalline silicon dioxide and aluminum hydroxide, and stir with a high-speed stirring device to form a stable suspension system;

[0020] Step 4: Dissolve L-ascorbic acid in a small amount of water, stir evenly and add to the suspension system. Add blueberry extract and rosehip extract to the base liquid under low-speed stirring conditions and continue stirring until evenly distributed. Add peppermint oil as a freshener and stir at a low speed. Add sodium hyaluronate, dissolve it in deionized water and slowly add it to the system and stir at a low speed to form a water-locking protective layer for tooth enamel.

[0021] Step 5: Place the mixed liquid in a vacuum environment for degassing, adjust the ratio of glycerin and water, and control the viscosity of the mixed liquid within the range of 20,000 to 30,000 cps. After cooling the mixed liquid to room temperature, fill and seal it.

[0022] The beneficial effects of the present invention are: by introducing the synergistic effect of stain removal active ingredients and enzyme components, the removal efficiency of berry stains is significantly improved. The innovative combination of nano-hydroxyapatite, strontium chloride, graphene oxide and sodium hyaluronate can not only repair the micropores and cracks on the enamel surface, but also form a smooth protective film on the tooth surface to prevent the acidic components of berry stains from eroding the teeth, while reducing the re-attachment of pigments. DETAILED DESCRIPTION

[0023] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below.

[0024] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0025] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0026] Example 1

[0027] A tooth-protecting toothpaste for removing berry stains comprises the following components, measured by weight: 23 parts of microcrystalline silicon dioxide, 5 parts of aluminum hydroxide, 1.5 parts of sodium lauroyl glutamate, 0.8 parts of pectinase, 0.3 parts of papain, 0.2 parts of laccase, 5.5 parts of nano-hydroxyapatite, 0.4 parts of strontium chloride, 0.03 parts of graphene oxide, 1.2 parts of L-ascorbic acid, 1.2 parts of blueberry extract, 0.8 parts of rosehip extract, 21 parts of glycerin, 16 parts of water, and 0.3 parts of peppermint oil.

[0028] The components of sodium pyrophosphate, sodium citrate, polyaspartic acid, and chitosan derivatives are shown in Table 1:

[0029] Table 1 Test data table

[0030]

[0031]

[0032] This embodiment also provides a method for preparing a toothpaste for removing berry stains, which comprises the following steps:

[0033] Step 1: Add glycerin and deionized water to a stirred reactor according to the formula ratio, stir evenly at a speed of 300-500rpm, maintain the temperature at 30-40℃, ensure that the glycerin is completely dissolved, and form a transparent and uniform base liquid. Then slowly add sodium lauroyl glutamate and continue to stir until it is completely dissolved to form a stable liquid phase system, providing a uniform medium for the dispersion of subsequent ingredients.

[0034] Step 2: Pre-dissolve sodium pyrophosphate, sodium citrate and polyaspartic acid in a small amount of deionized water to ensure that there is no lumps. After dissolution, slowly add them to the base liquid in turn, and keep stirring at a low speed (200-300rpm) for 5 minutes to form a stain removal active system. Pectinase and laccase are dissolved in warm water (<40℃) to ensure that the activity of the enzyme is not affected by high temperature. After dissolution, slowly add the base liquid, stir evenly (200rpm), and stir at a low speed for 10 minutes to avoid foaming. Papain is added last to further enhance the stain removal activity.

[0035] Step 3: Disperse the nanohydroxyapatite with deionized water and treat it with an ultrasonic disperser for 5 minutes to prevent particle agglomeration, then add the base liquid and stir evenly. Dissolve the chitosan derivative in warm water, stir at a low speed (200rpm) until completely dissolved, and then add it to the system to form a component of the enamel protective layer. After strontium chloride is directly dissolved in a small amount of water, add it slowly to ensure uniform distribution. Graphene oxide is dispersed with a high shear disperser (shear rate 2000rpm), and then the base liquid is added at a low speed. Add microcrystalline silicon dioxide and aluminum hydroxide gradually, and stir for 15 minutes using a high-speed stirring device (800-1000rpm) to ensure uniform distribution and form a stable suspension system.

[0036] Step 4: Dissolve L-ascorbic acid in a small amount of water, stir well and add to the system to further enhance the antioxidant performance. Add blueberry extract and rosehip extract to the base liquid under low-speed stirring (100-200rpm) to prevent degradation or loss of active ingredients under high shear. Continue stirring for 10 minutes until evenly distributed. Add peppermint oil as a freshener and stir at low speed for 5 minutes to prevent it from volatilizing during mixing. Add sodium hyaluronate, dissolve it in deionized water and slowly add it to the system, stirring at low speed to form a water-locking protective layer for tooth enamel.

[0037] Step 5: Place the mixed liquid in a vacuum environment (-0.08~-0.1MPa) for degassing for 10 minutes to remove bubbles in the mixing process and ensure that the toothpaste has a uniform texture. According to the formula requirements, adjust the ratio of glycerin and water to control the viscosity of the mixed liquid within the range of 20,000~30,000cps to meet the use requirements of toothpaste. Cool the mixed liquid to room temperature (25~30℃) to ensure that the stability of all active ingredients is not affected by high temperature. After cooling, use a hose filling machine to fill the toothpaste into the hose and seal it with high-frequency heat sealing equipment to ensure the airtightness and hygiene of the packaging. After filling, conduct finished product inspections on appearance, uniformity, viscosity and pH value to ensure that the product meets quality requirements.

[0038] Example 2

[0039] The toothpaste prepared in Example 1 was subjected to enamel color measurement, and the measurement process was as follows:

[0040] The toothpastes prepared in Example 1 and Comparative Examples 1 to 3 were subjected to enamel color measurement, and the measurement process was as follows:

[0041] (1) Preparation of in vitro tooth specimens: Fresh calf anterior teeth were selected, the root tissue was removed, and after ultrasonic cleaning, the tooth specimens were stored in 0.1 M phosphate buffer (PBS, pH 7.4). Teeth with no cracks, caries, or stains on the crown surface were selected as subsequent experimental models.

[0042] (2) Staining of in vitro tooth specimens:

[0043] Pretreatment: Immerse the prepared bovine tooth specimen in 1% hydrochloric acid, stir for 60 seconds, take it out and rinse it with clean water. Then immerse it in saturated sodium carbonate solution, stir for 60 seconds, take it out and rinse it with clean water. Finally, immerse it in 1% phytic acid solution, stir for 60 seconds, take it out and rinse it with clean water.

[0044] Prepare dye solution: Add black tea to hot water and stir evenly, then cool. Add FeCl3 solution maintained at 4°C before use. The final concentration of each component is 4.0g / L black tea and 0.05g / L FeCl3.

[0045] Staining: Immerse the pre-treated bovine tooth specimen in the staining solution and place it at 4°C for 7 days. After soaking, take out the bovine tooth and rinse it with water for 1-2 minutes.

[0046] (3) Colorimeter to measure L* value before and after brushing

[0047] After brushing teeth, a sample of the brushing solution was taken and the Fe content in the solution was detected by ICP-MS. 3+ 、Al 3+ The concentration was measured, and the color of the enamel was measured with a colorimeter (L* before brushing). The specimens were randomly assigned to the sample group and the control group, with 3 pieces in each group. There was no significant difference between the groups (P>0.05). The specimens were brushed with the test substance and the control substance respectively. The sample group used it twice a day and brushed for 3 minutes. During the treatment interval, the bovine tooth specimens were immersed in artificial saliva, and the environment was maintained at 37°C to simulate the oral environment. The total test cycle was 7 days. After the brushing cycle, the color of the enamel was measured again with a colorimeter (L* after brushing), and the difference in L* values ​​before and after brushing was calculated, ΔL*=L*(after brushing)-L*(before brushing).

[0048] (4) Results analysis

[0049] Perform t-test statistical analysis on the ΔL* value. If the ΔL* value of the sample group is greater than that of the control group and there is a significant difference (P<0.05), the sample has a stain removal and whitening effect.

[0050] The measurement data are shown in Table 2.

[0051] Table 2 Measurement results

[0052] Group Enamel before brushing L* Enamel after brushing L* Difference in L* before and after brushing (ΔL*) Control group 1 41.2 49.2 8 Control group 2 40.9 50.9 10 Control group 3 41.8 50.8 9 Control group 4 42.1 52.1 10 Control group 5 40.7 52.7 12 Experimental Group 1 41 55 14 Experimental Group 2 41.3 57.3 16 Experimental Group 3 42 56.5 14.5 Experimental Group 4 40.8 57.8 17 Experimental Group 5 41.5 59.5 18 Experimental Group 6 41.7 60.7 19 Test Group 7 42 62 20 Experimental Group 8 41 59.3 18.3 Experimental Group 9 40.8 61.5 20.7 Test Group 10 41 62.3 21.3 Experimental Group 11 41.6 63.6 22 Test Group 12 41.1 64.9 23.8 Test Group 13 41 65.5 24.5 Test Group 14 41.2 65.5 24.3 Test group 15 40.9 68.4 27.5

[0053] The metal ion removal rate of the toothpaste prepared in Example 1 was measured, and the measurement process was as follows:

[0054] Step 1: Prepare metal ion standard solution.

[0055] Add 10 mg / L FeCl3 and 10 mg / L AlCl3 to 1000 mL of deionized water to simulate the metal ion environment commonly found in tea stains, and take 50 mL of the metal solution into different beakers.

[0056] Step 2: Add the test formula.

[0057] The toothpaste solutions of different test groups (test groups 1-8 and comparative examples 1-3) were added to the metal ion solution, respectively, according to the recommended dilution ratio of toothpaste (1 g toothpaste + 50 mL deionized water) to ensure that the formula ingredients work effectively.

[0058] Step 3: Stir the reaction.

[0059] Use a magnetic stirrer to stir for 30 minutes to simulate the mixing effect of toothpaste in the oral environment. During this period, the temperature is controlled at 37°C and the pH is 6.5-7.5 to ensure the simulation of the oral environment.

[0060] Step 4: Centrifugal separation.

[0061] The precipitate and solution were separated by centrifugation at 5000 rpm for 10 min, and the supernatant was used for subsequent detection.

[0062] Step 5: ICP-MS measurement of metal concentration.

[0063] Take the supernatant and add 1M HNO3 to acidify it to make Fe 3+ 、Al 3+ Stable in solution. Determination of Fe using ICP-MS or ICP-OES 3+ 、Al 3+ of the residual concentration.

[0064] Step 6: Calculate the removal rate

[0065] Removal rate calculation formula:

[0066]

[0067] Where C0 is the initial concentration of metal ions before treatment, C f is the residual concentration of metal ions after treatment.

[0068] The measured data are shown in Table 3:

[0069]

[0070]

[0071] In summary, the beneficial effects of the present invention are as follows: (1) The present invention significantly improves the removal efficiency of berry stains by introducing the synergistic effect of active stain removal ingredients (sodium pyrophosphate, sodium citrate, polyaspartic acid, chitosan derivatives) and enzyme ingredients (pectinase, papain, laccase)**. Sodium pyrophosphate chelates metal ions in berry stains, sodium citrate neutralizes acidic components, polyaspartic acid and chitosan derivatives decompose the stable complex of pectin and pigments; pectinase decomposes the pectin matrix in berries, and laccase targets the oxidative degradation of polyphenolic pigments, thereby achieving deep pigment removal. This multi-mechanism synergistic effect effectively solves the problem of insufficient cleaning of stubborn berry stains by traditional toothpaste, and significantly improves the removal efficiency.

[0072] (2) The innovative combination of nano-hydroxyapatite, strontium chloride, graphene oxide and sodium hyaluronate can not only repair the micropores and cracks on the surface of tooth enamel, but also form a smooth protective film on the surface of teeth to prevent the acidic components of berry stains from eroding teeth and reduce the re-attachment of pigments. Sodium hyaluronate further enhances the water-locking and moisturizing effect on the tooth surface, improves the durability and smoothness of tooth enamel, and thus provides comprehensive protection.

[0073] (3) By adding natural ingredients such as blueberry extract and rosehip extract, the present invention not only enhances the stain removal effect, but also provides mild antioxidant protection, reducing oxidative damage while giving the toothpaste a natural fresh taste. The antioxidant ingredient L-ascorbic acid further decomposes the pigment molecules and protects the enamel from oxidation. The refreshing ingredient peppermint oil improves the user's oral experience, making the toothpaste suitable for daily and long-term use.

[0074] (4) The present invention avoids the use of high-hardness abrasives or strong irritating bleaching agents, and uses microcrystalline silicon dioxide and aluminum hydroxide as mild abrasives, which can effectively clean surface pigments without causing wear to tooth enamel. At the same time, a mild surfactant (sodium lauroyl glutamate) is selected, which has no irritation to the oral mucosa, further improving the safety of the toothpaste and making it suitable for long-term use.

[0075] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A toothpaste for removing berry stains, characterized in that: In terms of weight, it includes 24-31 parts of abrasives, 1-1.5 parts of surfactants, 4.8-7.5 parts of active ingredients for stain removal, 0.8-1.7 parts of enzyme ingredients, 5.42-6.75 parts of protective ingredients, 1-1.5 parts of antioxidant ingredients, 1.5-2.5 parts of natural extracts, 35-40 parts of wetting agents, and 0.2-0.5 parts of fresh ingredients; The stain removing active ingredients are sodium pyrophosphate, sodium citrate, polyaspartic acid and chitosan derivatives.

2. The toothpaste for removing berry stains according to claim 1, characterized in that: The mass ratio of the sodium pyrophosphate, sodium citrate, polyaspartic acid and chitosan derivative is 1.5-2.5:2-3:1-1.5:0.3-0.

5.

3. The toothpaste for removing berry stains according to claim 2, characterized in that: The mass ratio of the sodium pyrophosphate, sodium citrate, polyaspartic acid and chitosan derivative is 2.3:2.6:1.3:0.

35.

4. The toothpaste for removing berry stains according to claim 3, characterized in that: The enzyme components are pectinase, papain and laccase, wherein the mass ratio of pectinase, papain and laccase is 0.5-1:0.2-0.4:0.1-0.

3.

5. The toothpaste for removing berry stains according to any one of claims 1, 2 and 4, characterized in that: The protective components are nano hydroxyapatite, strontium chloride, graphene oxide and sodium hyaluronate, wherein the mass ratio of nano hydroxyapatite, strontium chloride, graphene oxide and sodium hyaluronate is 5-6: 0.3-0.5: 0.02-0.05: 0.1-0.

2.

6. The toothpaste for removing berry stains according to claim 5, characterized in that: The natural extracts are blueberry extract and rosehip extract, wherein the mass ratio of the blueberry extract to the rosehip extract is 1-1.5:0.5-1.

7. The toothpaste for removing berry stains according to claim 6, characterized in that: The friction agent is microcrystalline silicon dioxide and aluminum hydroxide, wherein the mass ratio of microcrystalline silicon dioxide to aluminum hydroxide is 20-25:4-6.

8. The toothpaste for removing berry stains according to claim 6 or 7, characterized in that: The surfactant is sodium lauroyl glutamate.

9. The toothpaste for removing berry stains according to claim 8, characterized in that: The antioxidant component is L-ascorbic acid; the wetting agent is glycerol and water, wherein the mass ratio of glycerol to water is 20-22:15-18; and the refreshing component is peppermint oil.

10. A method for preparing a toothpaste for removing berry stains according to any one of claims 1 to 9, characterized in that: The following steps are included: Step 1: Add glycerol and deionized water in a proportion to a stirred reactor, stir evenly to completely dissolve the glycerol to form a transparent and uniform base liquid, then slowly add sodium lauroyl glutamate, continue stirring until it is completely dissolved to form a stable liquid phase system; Step 2: Pre-dissolve sodium pyrophosphate, sodium citrate and polyaspartic acid in a small amount of deionized water, and slowly add them to the base liquid in turn after dissolution, stirring at a low speed to form a stain removal active system; dissolve pectinase and laccase in warm water, and slowly add them to the base liquid after dissolution, stirring evenly, stirring at a low speed, and finally add papain; Step 3: Disperse the nano-hydroxyapatite with deionized water and treat it with an ultrasonic disperser, then add the base liquid and stir evenly, dissolve the chitosan derivative in warm water, stir at a low speed until it is completely dissolved, and then add it to the stain removal active system to form a tooth enamel protective layer component, dissolve strontium chloride directly in a small amount of water and add it slowly, disperse graphene oxide with a high shear disperser, then add the base liquid at a low speed, gradually add microcrystalline silicon dioxide and aluminum hydroxide, and stir with a high-speed stirring device to form a stable suspension system; Step 4: Dissolve L-ascorbic acid in a small amount of water, stir evenly and add to the suspension system. Add blueberry extract and rosehip extract to the base liquid under low-speed stirring conditions and continue stirring until evenly distributed. Add peppermint oil as a freshener and stir at a low speed. Add sodium hyaluronate, dissolve it in deionized water and slowly add it to the system and stir at a low speed to form a water-locking protective layer for tooth enamel. Step 5: Place the mixed liquid in a vacuum environment for degassing, adjust the ratio of glycerin and water, and control the viscosity of the mixed liquid within the range of 20,000 to 30,000 cps. After cooling the mixed liquid to room temperature, fill and seal it.

Images