Hydrogel moisturizing eye protection patch and preparation method thereof

Abstract

The invention belongs to the technical field of eye patches, and particularly relates to a hydrogel moisturizing eye protection patch and a preparation method thereof. The anti-aging mask is prepared from the following components in parts by weight: 10 to 20 parts of sodium carboxymethyl cellulose, 5 to 10 parts of hyaluronic acid, 4 to 6 parts of polyethylene glycol diacrylate, 1 to 2 parts of aspartic acid, 3 to 6 parts of hydroxypropylated hyaluronic acid, 0.5 to 1 part of antioxidant, 0.5 to 1 part of vitamin E, 3 to 6.5 parts of active extract, 2 to 4 parts of jojoba oil, 8 to 12 parts of glycerol, 5 to 8 parts of propylene glycol, 0.5 to 1 part of phenoxyethanol and 85 to 100 parts of deionized water. According to the hydrogel moisturizing eye protection patch, the hydroscopicity is enhanced through hydroxypropylation of hyaluronic acid, a stable three-dimensional network structure is constructed with sodium carboxymethyl cellulose, active ingredients are uniformly dispersed, and layering is prevented. Glycerin is added to synergistically moisturize, and PEGDA is used as a cross-linking agent to improve the mechanical strength and softness and optimize the distribution of active components.

Description

Technical Field

[0001] The invention belongs to the technical field of eye patches, and particularly relates to a hydrogel moisturizing eye patch and a preparation method thereof. Background Art

[0002] With the advancement of technology and the change of lifestyle, people's interaction time with electronic screens has increased significantly. Whether it is work, study or entertainment, staring at devices such as computer screens, smartphones or tablets for a long time has become a part of daily life. This continuous eye muscle tension and reduced blinking frequency directly lead to problems such as dry eyes, fatigue, blurred vision and even headaches. These problems not only affect people's visual health, but also have a negative impact on the skin around the eyes. Environmental pollution is becoming more and more serious. Pollutants such as tiny particles (PM2.5), smoke, and pollen in the air are easy to adhere to the fragile skin around the eyes, causing irritation and accelerating the aging process of the skin. In addition, the low humidity in the air-conditioned environment further aggravates the loss of skin moisture, and with the increase of age, the skin's own moisturizing ability decreases. Under the combined effect of these factors, the skin around the eyes is more prone to fine lines, sagging and other problems. In order to meet the above challenges, the market has launched various types of eye care products, including eye creams, eye essences and eye patches. Among them, eye patches have become the first choice for many consumers because of their convenience and targetedness. However, although most existing eye patch products can provide an immediate moisturizing effect, their moisturizing effect is often not long-lasting due to the fact that their ingredients are easily volatile or quickly absorbed by the skin, and frequent use is required to maintain the ideal moisturizing state. In addition, some products may add more chemical preservatives or other irritants, which may cause adverse reactions to sensitive skin. Therefore, based on the above problems, it is extremely necessary to develop an eye patch that can provide an immediate and long-lasting moisturizing effect while ensuring safety. Summary of the invention

[0003] In view of the defects of the prior art, the object of the present invention is to provide a hydrogel moisturizing eye patch and a preparation method thereof.

[0004] The technical effect described in the present invention is achieved through the following technical scheme: a hydrogel moisturizing eye patch, which comprises the following ingredients in parts by weight: 10 to 20 parts of sodium carboxymethyl cellulose, 5 to 10 parts of hyaluronic acid, 4 to 6 parts of polyethylene glycol diacrylate, 1 to 2 parts of aspartic acid, 3 to 6 parts of hydroxypropylated hyaluronic acid, 0.5 to 1 part of antioxidant, 0.5 to 1 part of vitamin E, 3 to 6.5 parts of active extract, 2 to 4 parts of jojoba oil, 8 to 12 parts of glycerin, 5 to 8 parts of propylene glycol, 0.5 to 1 part of phenoxyethanol and 85 to 100 parts of deionized water.

[0005] Preferably, the specific preparation steps of the hydroxypropylated hyaluronic acid are as follows: A1: Add hyaluronic acid to deionized water, stir and dissolve evenly to obtain a 2-5wt% hyaluronic acid solution; adjust the pH of the hyaluronic acid solution to 8-9 with sodium bicarbonate solution, then slowly add 1,2-propylene glycol, control the reaction temperature at 30-40°C, and stir to react for 4-6 hours; A2: The solution after stirring in step A1 is adjusted to pH 5.5-6.5 with hydrochloric acid, cooled to room temperature, then added to an equal volume of ethanol, allowed to stand for 1 hour, centrifuged at 3000 rpm for 10-15 minutes, washed with cold ethanol, and freeze-dried at -40°C for 12 hours to obtain hydroxypropylated hyaluronic acid; Preferably, in step A1, the ratio of the amount of hyaluronic acid to that of 1,2-propylene glycol is 1 g: 0.02-0.03 mL.

[0006] Preferably, the antioxidant is any one of ascorbyl palmitate, tea polyphenols and tartrazine.

[0007] Preferably, the active extract is composed of the following raw materials in parts by weight: 0.5-1.5 parts of Centella asiatica extract, 1-2 parts of oat extract, 0.5-1 part of chamomile extract, 0.3-0.5 parts of dipotassium glycyrrhizinate, 0.2-0.5 parts of phycocyanin and 0.5-1 parts of arbutin.

[0008] Preferably, the Centella asiatica extract is prepared by a cold extraction method using ethanol as a solvent.

[0009] Preferably, the oat extract is prepared by a soaking method using deionized water as a solvent.

[0010] Preferably, the chamomile extract is prepared by an immersion method using ethanol as a solvent.

[0011] Preferably, another aspect of the present invention is to provide a method for preparing a hydrogel moisturizing eye patch, and the specific preparation steps are as follows: S1: adding sodium carboxymethyl cellulose to 20 to 30 times the weight of a 70 wt % ethanol solution, heating to 45 to 50° C., stirring to dissolve uniformly, then adding hydroxypropylated hyaluronic acid, continuing to stir, and obtaining a hydrogel matrix after dissolving uniformly; S2: Add glycerin, jojoba oil and propylene glycol to the hydrogel matrix prepared in step S1, stir and mix evenly, then add vitamin E, antioxidants, active extracts and phenoxyethanol, stir and disperse evenly, then add polyethylene glycol diacrylate and aspartic acid, stir and dissolve evenly; S3: Slowly add deionized water to the solution after stirring and dissolving uniformly in step S2, adjust the pH to 4.5-5.5 with 0.1M citric acid, perform ultrasonic treatment at 40-60W for 5-12min, let stand for 1-2h, then add glycerol and propylene glycol, stir and dissolve uniformly, perform liquid nitrogen treatment and freeze-drying, and obtain a hydrogel moisturizing eye patch; Preferably, in step S3, the liquid nitrogen freezing treatment parameters are: cooling to -80°C using liquid nitrogen at a rate of 1-2°C / min, then slowly heating to -40--20°C at a rate of 2-4°C / h, vacuum degree 0.01-0.1 mbar, time 20-24h.

[0012] The beneficial effects of the present invention are as follows: The hydrogel moisturizing eye patch prepared by the present invention makes full use of the synergistic mechanism between the raw materials in terms of ingredient selection and structural design to form a mutually reinforcing multi-level efficacy network. First, by introducing hydrophilic groups into hyaluronic acid through hydroxypropylation, it has higher water absorption and moisturizing capabilities. When it is used in conjunction with sodium carboxymethylcellulose, the polymer chain of hydroxypropylated hyaluronic acid and the anionic groups of sodium carboxymethylcellulose construct a stable and fine three-dimensional network structure through hydrogen bonds and electrostatic interactions, so that the active ingredients are evenly dispersed, stratification is prevented, and moisture is effectively locked; the network structure also produces a synergistic effect with glycerin, and the moisturizing properties of glycerin are fully utilized in this network, so that moisture continues to stay on the surface of the skin around the eyes, ensuring long-term moisturizing. As a cross-linking agent, polyethylene glycol diacrylate (PEGDA) forms a stable cross-linking network with hydroxypropylated hyaluronic acid through copolymerization, significantly improving the mechanical strength and softness of the hydrogel. At the same time, polyethylene glycol diacrylate is combined with sodium carboxymethylcellulose to form an interlocking network structure, further enhancing the stability and durability of the hydrogel, optimizing the distribution of active ingredients, and achieving long-lasting moisturizing and soothing effects. In addition, in the process of promoting collagen synthesis, Centella asiatica glycoside is superimposed with the deep moisturizing ability of hyaluronic acid to synergistically improve skin elasticity and density. In addition, the antioxidant effect of vitamin E can produce a synergistic effect with phycocyanin, allowing the skin to be repaired more deeply and protected from free radicals in a highly hydrated environment. Soothing extracts such as oats and chamomile are easier to disperse and adhere to the skin surface in the sodium carboxymethylcellulose matrix. Based on the enhanced adhesion properties of sodium carboxymethylcellulose, the soothing and anti-inflammatory molecules of oats can be in contact with the skin around the eyes for a long time. Dipotassium glycyrrhizinate helps reduce pigmentation in this environment and works with arbutin to even out skin tone. This combination not only amplifies the efficacy of individual ingredients, but also achieves the slow release and full play of plant active molecules through the viscosity regulation of sodium carboxymethylcellulose. Polyethylene glycol diacrylate and aspartic acid form polymer blocks to synergistically construct a cross-linked network with a fine pore structure, which not only improves the mechanical strength and softness of the hydrogel, but also optimizes the stability and release characteristics of the active ingredients by adjusting the pH value and ionic atmosphere of the microenvironment. Jojoba oil improves the softness in the network and slows down the loss of water together with glycerin, keeping the skin surface soft and comfortable. Finally, deionized water is used as an anti-solvent to promote the full dissolution of multiple components and ensure the uniformity and consistency of the hydrogel matrix. Liquid nitrogen rapid freezing and freeze-drying technology is used to avoid the formation of large ice crystals, ensuring the fineness and uniformity of the hydrogel structure, while shortening the freeze-drying time and reducing the risk of degradation of sensitive active ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0014] Figure 1 1 is a graph showing the stability test results of the hydrogel moisturizing eye patches prepared in Example 2 of the present invention and Comparative Examples 1 to 4; Figure 2 This is a graph showing the biocompatibility test results of the hydrogel moisturizing eye patch samples prepared in Examples 1 to 3 of the present invention; Figure 3 It is a test result diagram of the moisturizing performance of the hydrogel moisturizing eye patch prepared in Example 2 of the present invention and Comparative Examples 1 to 4; Figure 4 This is a SEM scanning electron microscope image of the hydrogel moisturizing eye patch prepared in Example 2 of the present invention. DETAILED DESCRIPTION

[0015] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. It should be noted that, unless otherwise specified, the raw materials involved in the present invention are purchased through conventional commercial channels.

[0016] Example 1: A hydrogel moisturizing eye patch, comprising the following ingredients in parts by weight: 10 parts of sodium carboxymethyl cellulose, 5 parts of hyaluronic acid, 4 parts of polyethylene glycol diacrylate, 1 part of aspartic acid, 3 parts of hydroxypropylated hyaluronic acid, 0.5 parts of antioxidant, 0.5 parts of vitamin E, 3 parts of active extracts, 2 parts of jojoba oil, 8 parts of glycerin, 5 parts of propylene glycol, 0.5 parts of phenoxyethanol and 85 parts of deionized water.

[0017] The specific preparation steps of hydroxypropylated hyaluronic acid are as follows: A1: Add 4g hyaluronic acid into 200mL deionized water, stir and dissolve evenly to obtain a 2wt% hyaluronic acid solution; adjust the pH of the hyaluronic acid solution to 8 with sodium bicarbonate solution, then slowly add 0.12mL of 1,2-propylene glycol, control the reaction temperature at 30℃, and stir and react for 4h; A2: The solution after stirring in step A1 was adjusted to pH 6.5 with hydrochloric acid, cooled to room temperature, then added to an equal volume of ethanol, allowed to stand for 1 hour, centrifuged at 3000 rpm for 10 minutes, washed with cold ethanol, and freeze-dried at -40°C for 12 hours to obtain hydroxypropylated hyaluronic acid; The active extract is composed of the following raw materials in parts by weight: 0.5 parts of Centella asiatica extract, 1 part of oat extract, 0.5 parts of chamomile extract, 0.3 parts of dipotassium glycyrrhizinate, 0.2 parts of phycocyanin and 0.5 parts of arbutin; Centella asiatica extract was prepared by cold extraction method using ethanol as solvent; The oat extract was prepared by soaking method using deionized water as solvent; Chamomile extract was prepared by an immersion method using ethanol as solvent; The specific preparation steps of the hydrogel moisturizing eye patch are as follows: S1: adding sodium carboxymethyl cellulose to 20 times the weight of a 70wt% ethanol solution, heating to 45°C, stirring to dissolve evenly, then adding hydroxypropylated hyaluronic acid, continuing to stir, and obtaining a hydrogel matrix after dissolving evenly; S2: Add glycerin, jojoba oil and propylene glycol to the hydrogel matrix prepared in step S1, stir and mix evenly, then add vitamin E, antioxidants, active extracts and phenoxyethanol, stir and disperse evenly, then add polyethylene glycol diacrylate and aspartic acid, stir and dissolve evenly; S3: Slowly add deionized water to the solution after stirring and dissolving uniformly in step S2, adjust the pH to 4.5 with 0.1M citric acid, ultrasonically treat at 40W for 5 minutes, let stand for 1 hour, then add glycerol and propylene glycol, stir and dissolve uniformly, use liquid nitrogen to cool to -80°C at a rate of 1°C / min, then slowly heat to -40°C at a rate of 2°C / h, vacuum degree 0.01mbar, time 20 hours, to obtain a hydrogel moisturizing eye patch.

[0018] Example 2: A hydrogel moisturizing eye patch, comprising the following ingredients in parts by weight: 18 parts of sodium carboxymethyl cellulose, 8 parts of hyaluronic acid, 5 parts of polyethylene glycol diacrylate, 1.5 parts of aspartic acid, 5 parts of hydroxypropylated hyaluronic acid, 0.8 parts of antioxidant, 0.8 parts of vitamin E, 5.5 parts of active extract, 3 parts of jojoba oil, 10 parts of glycerin, 7 parts of propylene glycol, 0.8 parts of phenoxyethanol and 95 parts of deionized water.

[0019] The specific preparation steps of hydroxypropylated hyaluronic acid are as follows: A1: Add 8g of hyaluronic acid into 200mL of deionized water, stir and dissolve evenly to obtain a 4wt% hyaluronic acid solution; adjust the pH of the hyaluronic acid solution to 8.5 with sodium bicarbonate solution, then slowly drop 0.2mL of 1,2-propylene glycol, control the reaction temperature at 37°C, and stir and react for 5h; A2: The solution after stirring in step A1 was adjusted to pH 6 with hydrochloric acid, cooled to room temperature, then added to an equal volume of ethanol, allowed to stand for 1 hour, centrifuged at 3000 rpm for 12 minutes, washed with cold ethanol, and freeze-dried at -40°C for 12 hours to obtain hydroxypropylated hyaluronic acid; The active extract is composed of the following raw materials in parts by weight: 1.2 parts of Centella asiatica extract, 1.8 parts of oat extract, 0.8 parts of chamomile extract, 0.4 parts of dipotassium glycyrrhizinate, 0.4 parts of phycocyanin and 0.9 parts of arbutin; Centella asiatica extract was prepared by cold extraction method using ethanol as solvent; The oat extract was prepared by soaking method using deionized water as solvent; Chamomile extract was prepared by an immersion method using ethanol as solvent; The specific preparation steps of the hydrogel moisturizing eye patch are as follows: S1: adding sodium carboxymethyl cellulose to 25 times the weight of a 70wt% ethanol solution, heating to 48°C, stirring to dissolve evenly, then adding hydroxypropylated hyaluronic acid, continuing to stir, and obtaining a hydrogel matrix after dissolving evenly; S2: Add glycerin, jojoba oil and propylene glycol to the hydrogel matrix prepared in step S1, stir and mix evenly, then add vitamin E, antioxidants, active extracts and phenoxyethanol, stir and disperse evenly, then add polyethylene glycol diacrylate and aspartic acid, stir and dissolve evenly; S3: Slowly add deionized water to the solution after stirring and dissolving uniformly in step S2, adjust the pH to 5.5 with 0.1M citric acid, ultrasonically treat at 50W for 10 minutes, let stand for 1.5 hours, then add glycerol and propylene glycol, stir and dissolve uniformly, use liquid nitrogen to cool to -80°C at a rate of 1.5°C / min, then slowly heat to -20°C at a rate of 4°C / h, vacuum degree 0.01mbar, time 24 hours, to obtain a hydrogel moisturizing eye patch.

[0020] Example 3: A hydrogel moisturizing eye patch, comprising the following ingredients in parts by weight: 20 parts of sodium carboxymethyl cellulose, 10 parts of hyaluronic acid, 6 parts of polyethylene glycol diacrylate, 2 parts of aspartic acid, 6 parts of hydroxypropylated hyaluronic acid, 1 part of antioxidant, 1 part of vitamin E, 6.5 parts of active extracts, 4 parts of jojoba oil, 12 parts of glycerin, 8 parts of propylene glycol, 1 part of phenoxyethanol and 100 parts of deionized water.

[0021] The specific preparation steps of hydroxypropylated hyaluronic acid are as follows: A1: Add 10g hyaluronic acid into 200mL deionized water, stir and dissolve evenly to obtain a 5wt% hyaluronic acid solution; adjust the pH of the hyaluronic acid solution to 9 with sodium bicarbonate solution, then slowly drop 0.2mL 1,2-propylene glycol, control the reaction temperature at 40℃, and stir and react for 6h; A2: The solution after stirring in step A1 was adjusted to pH 5.5 with hydrochloric acid, cooled to room temperature, then added to an equal volume of ethanol, allowed to stand for 1 hour, centrifuged at 3000 rpm for 15 minutes, washed with cold ethanol, and freeze-dried at -40°C for 12 hours to obtain hydroxypropylated hyaluronic acid; The active extract is composed of the following raw materials in parts by weight: 1.5 parts of Centella asiatica extract, 2 parts of oat extract, 1 part of chamomile extract, 0.5 parts of dipotassium glycyrrhizinate, 0.5 parts of phycocyanin and 1 part of arbutin; Centella asiatica extract was prepared by cold extraction method using ethanol as solvent; The oat extract was prepared by soaking method using deionized water as solvent; Chamomile extract was prepared by an immersion method using ethanol as solvent; The specific preparation steps of the hydrogel moisturizing eye patch are as follows: S1: adding sodium carboxymethyl cellulose to 30 parts by weight of a 70wt% ethanol solution, heating to 50°C, stirring to dissolve evenly, then adding hydroxypropylated hyaluronic acid, continuing to stir, and obtaining a hydrogel matrix after dissolving evenly; S2: Add glycerin, jojoba oil and propylene glycol to the hydrogel matrix prepared in step S1, stir and mix evenly, then add vitamin E, antioxidants, active extracts and phenoxyethanol, stir and disperse evenly, then add polyethylene glycol diacrylate and aspartic acid, stir and dissolve evenly; S3: Slowly add deionized water to the solution after stirring and dissolving uniformly in step S2, adjust the pH to 5 with 0.1M citric acid, ultrasonically treat at 60W for 12min, let stand for 2h, then add glycerol and propylene glycol, stir and dissolve uniformly, use liquid nitrogen to cool to -80℃ at a rate of 2℃ / min, then slowly heat to -30℃ at a rate of 3℃ / h, vacuum degree 0.05mbar, time 22h, to obtain a hydrogel moisturizing eye patch.

[0022] Comparative Example 1: The operation of Comparative Example 1 is substantially the same as that of Example 2, except that polyethylene glycol diacrylate is not added in Comparative Example 1.

[0023] Comparative Example 2: The operation of Comparative Example 2 is substantially the same as that of Example 2, except that aspartic acid is not added in Comparative Example 2.

[0024] Comparative Example 3: The operation of Comparative Example 3 is basically the same as that of Example 2, except that hyaluronic acid is used in Comparative Example 3 to replace hydroxypropylated hyaluronic acid.

[0025] Comparative Example 4: The operation of Comparative Example 4 is basically the same as that of Example 2, except that liquid nitrogen freezing treatment is not used in Comparative Example 4, and freeze drying is directly performed at -40°C.

[0026] Performance Testing: Stability test: The hydrogel moisturizing eye patch prepared in Example 2 and Comparative Examples 1 to 4 was placed in an environment of 40°C and 80% humidity for 28 days, and the pH value of the gel was measured and recorded on the 3rd, 7th, 14th and 28th days. The results are as follows: Figure 1 shown.

[0027] Depend on Figure 1 As a result, the pH of the hydrogel moisturizing eye patch prepared by the present invention fluctuates within the range of ±0.2 during the storage time of 28 days, and has excellent stability; from the results of Comparative Example 1 and Example 2, it can be seen that the lack of polyethylene glycol diacrylate may cause the hydrogel to lack a strong cross-linked structure, and the moisture retention performance is affected, and the loss of water may cause a large fluctuation in pH; from the results of Comparative Example 2 and Example 2, it can be seen that the lack of aspartic acid, but the formula still contains polyethylene glycol diacrylate and hydroxypropylated hyaluronic acid, has a good promoting effect on the stability of pH, and the pH fluctuation range is small; from the results of Comparative Example 3 and Example 3, it can be seen that the use of hyaluronic acid to replace hydroxypropylated hyaluronic acid may affect the cross-linking of the hydrogel, which may cause a slight decrease in the pH value of the system. In addition, since hyaluronic acid itself is highly acidic, this may lead to a lower initial pH change and range fluctuation; from the results of Comparative Example 4 and Example 2, it can be seen that not using liquid nitrogen freezing treatment may cause the hydrogel to lose water faster, affect the structural stability, and then affect the pH stability, resulting in a larger range of pH fluctuations.

[0028] Biocompatibility test: The hydrogel moisturizing eye patch samples prepared in Examples 1 to 3 were placed at the bottom of the culture plate, and each group of samples was evenly distributed in a 96-well plate with 8 wells. 50 μL of DMEM medium was added to each well, and then the fibroblasts were diluted to 1×10 4After 50 μL of 5 mg / mL of MTT solution was added to the wells, the temperature was set to 37°C and the CO2 concentration was 5%. After 24 hours of incubation, 5 μL of 5 mg / mL MTT solution was added. After further incubation for 4 hours, the culture medium in the wells was aspirated, and then 50 μL of dimethyl sulfoxide was added to the wells. The absorbance (OD value) was measured at 490 nm using a microplate reader, and the activity percentage was calculated [biocompatibility (%) = (OD value of the embodiment - OD value of the negative control group) / (OD value of the positive control group - OD value of the negative control group) × 100%], the positive control group: treated with 10wt% dimethyl sulfoxide solution; the negative control group: untreated cells were used as the control; the cell survival rate results are shown in FIG. Figure 2 shown.

[0029] Depend on Figure 2 The results show that the hydrogel moisturizing eye patch prepared by the present invention has no obvious effect on the activity of cells, no obvious toxic damage to cells, and has excellent biocompatibility.

[0030] Moisturizing performance test: 0.5 g of the hydrogel moisturizing eye patch samples prepared in Example 2 and Comparative Examples 1 to 4 were soaked in deionized water for 30 min, and their weight changes were measured at 5 min, 10 min, 20 min and 30 min, respectively, and their water absorption rate was calculated (water absorption rate = (weight after water absorption - weight before water absorption) / weight before water absorption × 100%). The results are as follows: Figure 3 shown.

[0031] Depend on Figure 3 As a result, the hydrogel moisturizing eye patch prepared by the present invention can effectively, slowly and continuously absorb water, and has excellent moisturizing performance and sustained release effect; from the results of comparative example 1 and example 2, it can be seen that the lack of polyethylene glycol diacrylate leads to an unstable cross-linking network, a loose hydrogel structure, enhanced water absorption, a higher water absorption rate in the early stage, and a long-term moisturizing performance is affected, and disintegration occurs in the later stage of water absorption; from the results of comparative example 2 and example 2, it can be seen that the lack of aspartic acid weakens the pH adjustment ability, but based on the cross-linking stability provided by polyethylene glycol diacrylate, the water absorption rate is faster, and the sustained release performance is affected to a certain extent; from the results of comparative example 3 and example 2, it can be seen that hyaluronic acid has stronger water absorption, but the cross-linking network is not as stable as hydroxypropylated hyaluronic acid, and it shows a higher water absorption rate in a shorter time; from the results of comparative example 4 and example 2, it can be seen that the lack of liquid nitrogen freezing treatment leads to a relatively loose hydrogel structure, a higher water absorption rate in the early stage, but reduced stability, and an excessively fast water absorption rate is not conducive to slow release.

[0032] Spectrum test: The microstructure of the hydrogel sample prepared in Example 2 of the present invention was observed by scanning electron microscope to obtain a SEM scanning electron microscope image. The results are as follows: Figure 4 shown.

[0033] Depend on Figure 4 The results show that the SEM image has an obvious hydrogel porous structure, which is suitable for the release of active ingredients. At the same time, the image has a dense and regular network structure, which can effectively lock in moisture and ensure the uniform dispersion of active ingredients.

[0034] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A hydrogel moisturizing eye patch, characterized in that: The composition includes the following ingredients in parts by weight: 10 to 20 parts of sodium carboxymethyl cellulose, 5 to 10 parts of hyaluronic acid, 4 to 6 parts of polyethylene glycol diacrylate, 1 to 2 parts of aspartic acid, 3 to 6 parts of hydroxypropylated hyaluronic acid, 0.5 to 1 part of antioxidant, 0.5 to 1 part of vitamin E, 3 to 6.5 parts of active extract, 2 to 4 parts of jojoba oil, 8 to 12 parts of glycerin, 5 to 8 parts of propylene glycol, 0.5 to 1 part of phenoxyethanol and 85 to 100 parts of deionized water.

2. A hydrogel moisturizing eye patch according to claim 1, characterized in that: The specific preparation steps of the hydroxypropylated hyaluronic acid are as follows: A1: Add hyaluronic acid into deionized water, stir and dissolve evenly to obtain a hyaluronic acid solution; adjust the pH of the hyaluronic acid solution with a sodium bicarbonate solution, then slowly drop 1,2-propylene glycol, control the reaction temperature, and stir the reaction; A2: The pH of the solution after stirring in step A1 is adjusted with hydrochloric acid, cooled to room temperature, then added to an equal volume of ethanol, allowed to stand, centrifuged, washed with cold ethanol, and freeze-dried to obtain hydroxypropylated hyaluronic acid.

3. A hydrogel moisturizing eye patch according to claim 2, characterized in that: In step A1, the ratio of the amount of hyaluronic acid to that of 1,2-propylene glycol is 1 g: 0.02-0.03 mL.

4. A hydrogel moisturizing eye patch according to claim 3, characterized in that: The antioxidant is any one of ascorbyl palmitate, tea polyphenols and tartrazine.

5. The hydrogel moisturizing eye patch according to claim 4, characterized in that: The active extract is composed of the following raw materials in parts by weight: 0.5-1.5 parts of Centella asiatica extract, 1-2 parts of oat extract, 0.5-1 part of chamomile extract, 0.3-0.5 parts of dipotassium glycyrrhizinate, 0.2-0.5 parts of phycocyanin and 0.5-1 parts of arbutin.

6. A method for preparing the hydrogel moisturizing eye patch according to any one of claims 1 to 5, characterized in that: The specific preparation steps are as follows: S1: adding sodium carboxymethyl cellulose to an ethanol solution, heating, stirring and dissolving uniformly, then adding hydroxypropylated hyaluronic acid, continuing to stir, and dissolving uniformly to obtain a hydrogel matrix; S2: Add glycerin, jojoba oil and propylene glycol to the hydrogel matrix prepared in step S1, stir and mix evenly, then add vitamin E, antioxidants, active extracts and phenoxyethanol, stir and disperse evenly, then add polyethylene glycol diacrylate and aspartic acid, stir and dissolve evenly; S3: Slowly add deionized water to the solution after stirring and dissolving uniformly in step S2, adjust the pH with citric acid, perform ultrasonic treatment, let stand, then add glycerol and propylene glycol, stir and dissolve uniformly, treat with liquid nitrogen and freeze-dry to obtain a hydrogel moisturizing eye patch.

7. The method for preparing a hydrogel moisturizing eye patch according to claim 6, characterized in that: In step S3, the liquid nitrogen freezing treatment parameters are: using liquid nitrogen to cool to -80°C at a rate of 1-2°C / min, and then slowly heating to -40--20°C at a rate of 2-4°C / h, with a vacuum degree of 0.01-0.1 mbar and a time of 20-24h.

Images