Method and device for selecting default calibration curve and sample analysis system

Abstract

The invention relates to a default calibration curve selection method and device and a sample analysis system. The method comprises the steps that a list containing a plurality of calibration curves used for detecting reagents is displayed on a display device of a sample analyzer, the sample analyzer comprises a sample loading mechanism and a reagent loading mechanism, the sample loading mechanism is used for loading samples to be detected, the reagent loading mechanism can contain kits needed by all detection items, and the reagent loading mechanism is used for loading the samples to be detected. A detection reagent to-be-detected sample is contained in the kit; in response to a selection operation for the calibration curves in the list, determining a target calibration curve according to the selection operation; setting the target calibration curve as a current default calibration curve, wherein the sample analyzer calculates the concentration data of the sample to be detected by means of the default calibration curve when obtaining the detection signal. According to the scheme provided by the invention, flexible selection of the default calibration curve can be realized, so that the accuracy of the sample detection result value is improved.

Description

Technical Field

[0001] The present application relates to the technical field of sample analysis, and in particular to a method and device for selecting a default calibration curve and a sample analysis system. Background Art

[0002] The sample analyzer is an instrument that uses a test reagent to analyze a blood sample. In the test, the test reagent corresponding to the substance to be tested in the blood is used to detect the concentration of the substance to be tested. The test reagent and the sample are mixed to produce a biochemical reaction, which emits a light signal. This signal reflects the concentration of the substance to be tested. The concentration of the substance to be tested can be calculated based on the conversion curve between the light signal value and the concentration stored in the sample analyzer.

[0003] In the related art, only a fixed calibration curve can be used as the curve for calculating sample results, but this curve may not be effective. For example, due to quality problems of the calibration material or the reading of the photoelectric detector of the sample analyzer, the calibration curve is not ideal, resulting in the actual detection result value converted to be inaccurate. Summary of the invention

[0004] In order to solve or partially solve the problems existing in the related art, the present application provides a method, device and sample analysis system for selecting a default calibration curve, which can realize flexible selection of the default calibration curve, thereby improving the accuracy of the sample detection result value.

[0005] The first aspect of the present application provides a method for selecting a default calibration curve.

[0006] Displaying a list of multiple calibration curves for testing reagents on a display device of a sample analyzer, wherein the sample analyzer includes a sample loading mechanism and a reagent loading mechanism, wherein the sample loading mechanism can load samples to be tested, and the reagent loading mechanism can accommodate a reagent kit required for each test item, wherein the reagent kit contains reagents to be tested;

[0007] In response to a selection operation on a calibration curve in the list, determining a target calibration curve according to the selection operation;

[0008] The target calibration curve is set as the current default calibration curve, wherein the analyzer calculates the concentration data of the sample to be tested with the help of the default calibration curve when obtaining the detection signal.

[0009] In some embodiments, the multiple calibration curves displayed by the display device are obtained after multiple calibration tests are performed on at least the same batch of detection reagents in the sample analyzer.

[0010] In some embodiments, determining the target calibration curve according to the selection operation includes:

[0011] Determining the distances between the plurality of calibration curves in the list and each calibration concentration point, and sorting the plurality of calibration curves according to the distances;

[0012] According to the selection operation, the calibration curve closest to each calibration concentration point is determined as the target calibration curve.

[0013] In some embodiments, determining the target calibration curve according to the selection operation includes:

[0014] The distances between the multiple calibration curves in the list and the respective calibration concentration points are determined. If the distances are greater than a set deviation threshold, the calibration curve corresponding to the adjacent batch of the detection reagent to the current batch of the detection reagent is determined as the target calibration curve according to the selection operation.

[0015] In some embodiments, setting the target calibration curve as a default calibration curve comprises:

[0016] Determining whether the target calibration curve is valid;

[0017] If it is valid and within the validity period, the target calibration curve is determined as the current default calibration curve.

[0018] In some embodiments, before setting the target calibration curve as the current default calibration curve, the method includes:

[0019] It is determined whether there is an initial default calibration curve in the sample analyzer. If so, the initial default calibration curve is set as a non-default calibration curve, and the target calibration curve is set as a current default calibration curve.

[0020] A second aspect of the present application provides a device for selecting a default calibration curve, comprising:

[0021] A calibration display module, used to display a list of multiple calibration curves for detection reagents on a display device of a sample analyzer; wherein the sample analyzer includes a sample loading mechanism and a reagent loading mechanism, wherein the sample loading mechanism can load a sample to be tested, and the reagent loading mechanism can accommodate a reagent kit required for each detection item, wherein the reagent kit contains a detection reagent;

[0022] A first processing module, configured to respond to a selection operation on a calibration curve in the list and determine a target calibration curve according to the selection operation;

[0023] The second processing module is used to set the target calibration curve as the current default calibration curve, wherein the sample analyzer calculates the concentration data of the sample to be tested with the help of the default calibration curve when obtaining the detection signal.

[0024] In some embodiments, the first processing module includes:

[0025] A distance determination submodule, used to determine the distances between the plurality of calibration curves in the list and each calibration concentration point;

[0026] The curve selection submodule is used to sort the error values ​​corresponding to the multiple calibration curves, and determine the calibration curve with the smallest error value as the target calibration curve according to the selection operation.

[0027] A third aspect of the present application provides a sample analysis system, including a sample analyzer, wherein the sample analyzer is provided with the device provided in the second aspect above.

[0028] A fourth aspect of the present application provides an electronic device, including:

[0029] Processor; and

[0030] A memory having executable codes stored thereon, which, when executed by the processor, causes the processor to execute the method described in the first aspect above.

[0031] The technical solution provided by this application may have the following beneficial effects:

[0032] The present application displays a list of multiple calibration curves for detection reagents on a display device of a sample analyzer; then responds to a selection operation for a calibration curve in the list, determines a target calibration curve according to the selection operation; then sets the target calibration curve as the current default calibration curve, and the sample analyzer calculates the concentration data of the sample to be tested with the help of the default calibration curve when obtaining a detection signal. After the above processing, the defect of the related art that only a fixed calibration curve can be used as a curve for calculating sample results can be avoided, and the flexible selection of the default calibration curve is achieved, thereby improving the accuracy of the sample detection result value.

[0033] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] The above and other objects, features and advantages of the present application will become more apparent by describing in more detail exemplary embodiments of the present application in conjunction with the accompanying drawings, wherein the same reference numerals generally represent the same components in the exemplary embodiments of the present application.

[0035] Figure 1 It is a flowchart of a method for selecting a default calibration curve shown in an embodiment of the present application;

[0036] Figure 2is another flow chart of the method for selecting a default calibration curve shown in an embodiment of the present application;

[0037] Figure 3 is a schematic structural diagram of a device for selecting a default calibration curve shown in an embodiment of the present application;

[0038] Figure 4 It is a schematic diagram of the structure of an electronic device shown in an embodiment of the present application. DETAILED DESCRIPTION

[0039] The embodiments of the present application will be described in more detail below with reference to the accompanying drawings. Although the embodiments of the present application are shown in the accompanying drawings, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided to make the present application more thorough and complete, and to fully convey the scope of the present application to those skilled in the art.

[0040] The terms used in this application are for the purpose of describing specific embodiments only and are not intended to limit this application. The singular forms of "a", "said" and "the" used in this application and the appended claims are also intended to include plural forms unless the context clearly indicates other meanings. It should also be understood that the term "and / or" used herein refers to and includes any or all possible combinations of one or more associated listed items.

[0041] It should be understood that although the terms "first", "second", "third", etc. may be used in this application to describe various information, this information should not be limited to these terms. These terms are only used to distinguish the same type of information from each other. For example, without departing from the scope of this application, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Thus, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0042] In the related art, only a fixed calibration curve can be used as the curve for calculating the sample results, but this curve may not be effective. For example, due to quality problems of the calibration material or the reading of the photoelectric detector of the sample analyzer, the calibration curve is not ideal, resulting in the final converted actual test result value not being accurate enough. In response to the above problems, the embodiments of the present application provide a method, device and sample analysis system for selecting a default calibration curve, which can realize flexible selection of the default calibration curve during the sample concentration test, thereby improving the accuracy of the sample test result value.

[0043] The technical solution of the embodiments of the present application is described in detail below with reference to the accompanying drawings.

[0044] Figure 1 It is a flowchart of a method for selecting a default calibration curve shown in an embodiment of the present application.

[0045] See also Figure 1 , the method of the embodiment of the present application includes:

[0046] S101. Displaying a list of multiple calibration curves for detection reagents on a display device of a sample analyzer, wherein the sample analyzer comprises a sample loading mechanism and a reagent loading mechanism, wherein the sample loading mechanism is capable of loading samples to be tested, and the reagent loading mechanism is capable of accommodating a reagent kit required for each detection item, wherein the reagent kit contains reagents to be detected, and the detection reagents may be reagents to be calibrated.

[0047] Wherein, the sample analyzer is a chemiluminescence analyzer, in particular, a photoluminescence analyzer, and the display device can be a display screen provided on the sample analyzer. The chemiluminescence analyzer also includes an incubation mechanism and a detection mechanism. The incubation mechanism is used to incubate a mixture of a sample to be tested and a detection reagent to achieve optimal reaction conditions. The detection mechanism is used to detect the light signal emitted by the mixture.

[0048] The calibration curve is obtained by testing a calibrator with a standard concentration. During calibration, a calibrator with a known concentration is used as the sample to be tested and mixed with the detection reagent to generate a light signal. The generated light signal is used as the standard signal value corresponding to the concentration of the calibrator. Calibrations with different concentration gradients are performed in turn to obtain a conversion curve between the light signal value and the concentration. This conversion curve is the calibration curve.

[0049] S102: In response to a selection operation on a calibration curve in the list, determine a target calibration curve according to the selection operation.

[0050] The user issues an operation instruction to select a calibration curve as a target calibration curve, and the sample analyzer executes the selection operation according to the instruction.

[0051] S103, setting the target calibration curve as the current default calibration curve, wherein the sample analyzer calculates the concentration data of the sample to be tested with the help of the default calibration curve when obtaining the detection signal.

[0052] After the target calibration curve is set as the current default calibration curve, when the kit is used for subsequent tests, the sample analyzer can obtain the concentration data of the sample to be tested with the help of the default calibration curve.

[0053] Through the above method, during the test of the sample analyzer on the sample to be tested, the user can select a suitable calibration curve from multiple calibration curves as the default calibration curve according to the reagent testing requirements, avoiding the situation in the related technology that only a fixed calibration curve can be used as the default calibration curve for calculating the sample results. The default calibration curve can be flexibly selected, and the concentration of the reagent of unknown concentration and the same type as the sample reagent can be tested more accurately.

[0054] In the related art, since different batches of detection reagents may have slight differences, each batch of detection reagents needs to be calibrated, but if only one calibration test is performed, the generated calibration curve may have errors in the test results. Even if the calibration curve is allowed to be updated in some existing technical solutions, the common practice in the existing technical solutions is to automatically overwrite the original calibration curve with the latest completed calibration curve, so it is difficult for users to select a more suitable calibration curve, which sometimes leads to problems with detection accuracy.

[0055] The present application eliminates the practice in the prior art of automatically overwriting the original calibration curve with the latest calibration curve, so that the user can select the calibration curve that best suits the current test from multiple valid calibration curves to obtain the most accurate test results.

[0056] In order to improve the test accuracy, in the method of this embodiment, the multiple calibration curves displayed on the display device are obtained after multiple calibration tests are performed on at least the same batch of detection reagents in the sample analyzer. The detection reagents in the same batch are usually the same reagents to be calibrated. The generated multiple calibration curves are stored in the sample analyzer and displayed in the form of a list on the display device for the user to select an optimal calibration curve as the target calibration curve.

[0057] In this embodiment, in the sample analyzer, the same calibrator may be used to perform multiple calibration tests on at least the same batch of detection reagents to obtain multiple curves, or different calibrators may be used to perform multiple calibration tests to obtain multiple calibration curves.

[0058] Figure 2 It is another flowchart of the method for selecting a default calibration curve shown in an embodiment of the present application.

[0059] See also Figure 2 , the method provided in this embodiment includes:

[0060] S101 . Displaying a list including a plurality of calibration curves for detection reagents on a display device of a sample analyzer.

[0061] Among them, 3-6 concentration gradient data can be obtained according to the detection reagents of the test kit of a certain test item, and these 3-6 concentration gradient data are fitted according to the selected fitting algorithm to obtain a fitting curve, which is the calibration curve.

[0062] S102: In response to a selection operation on a calibration curve in the list, determine a target calibration curve according to the selection operation.

[0063] S113, determine whether there is an initial default calibration curve in the sample analyzer, if yes, go to step S133; if no, go to S123. Whether the target calibration curve is valid refers to the validity judgment of the calibration curve, that is, whether the difference between the detection value of each calibration point and the fitted curve meets the predetermined standard.

[0064] S123. Setting the target calibration curve as the current default calibration curve.

[0065] S133, setting the initial default calibration curve as the non-default calibration curve, and setting the target calibration curve as the current default calibration curve, so that the initial calibration curve is replaced by the newly selected default calibration curve.

[0066] In some embodiments, determining the target calibration curve according to the selection operation includes: determining the distance between the multiple calibration curves in the list and each calibration concentration point; if the distance is greater than a set deviation threshold, then determining the calibration curve corresponding to the adjacent batch of detection reagents of the current batch of detection reagents as the target calibration curve according to the selection operation, thereby selecting the optimal default calibration curve and improving the detection accuracy of the current default calibration curve for the reagent concentration.

[0067] In some embodiments, determining the target calibration curve according to the selection operation includes: determining the distance between the multiple calibration curves in the list and each calibration concentration point; if the distance is greater than a set deviation threshold, then determining the calibration curve corresponding to the detection reagent of the batch adjacent to the current batch of detection reagent as the target calibration curve according to the selection operation; after such processing, when each batch of detection reagent is only calibrated once, for the detection reagent corresponding to the calibration curve with an unsatisfactory calibration, the calibration curve of the detection reagent of the batch adjacent to the batch of detection reagent can also be selected as the default calibration curve, thereby further improving the detection accuracy of the default calibration curve.

[0068] Corresponding to the aforementioned application function implementation method embodiment, the present application also provides a device for selecting a default calibration curve.

[0069] Figure 3 It is a structural schematic diagram of a device for selecting a default calibration curve shown in an embodiment of the present application.

[0070] See also Figure 3 The default calibration curve selection device 200 includes a calibration display module 201 , a first processing module 202 and a second processing module 203 .

[0071] The calibration display module 201 is used to display a list of multiple calibration curves for detection reagents on the display device of the sample analyzer, wherein the sample analyzer includes a sample loading mechanism and a reagent loading mechanism, the sample loading mechanism is used to load the sample to be tested, and the reagent loading mechanism can accommodate the reagent kit required for each detection item, and the reagent kit contains the detection reagent; the first processing module 202 is used to respond to the selection operation of the calibration curve in the list of the calibration display module 201, and determine the target calibration curve according to the selection operation; the second processing module 203 is used to set the target calibration curve as the current default calibration curve, wherein the sample analyzer calculates the concentration data of the sample to be tested in the current reagent kit with the help of the default calibration curve when obtaining the detection signal.

[0072] In some embodiments, the first processing module 202 includes a distance determination submodule 212 and a curve selection submodule 222. The distance determination submodule 212 is used to determine the distances between the multiple calibration curves in the list and each calibration concentration point. The curve selection submodule 222 is used to sort the error values ​​corresponding to the multiple calibration curves, and determine the calibration curve with the smallest error value as the target calibration curve according to the selection operation.

[0073] Regarding the device in the above embodiment, the specific manner in which each module performs operations has been described in detail in the embodiment of the method, and will not be elaborated again here.

[0074] The device provided in this embodiment allows the user to select an appropriate calibration curve from multiple calibration curves as the default calibration curve according to the reagent testing requirements, avoiding the use of only a fixed calibration curve as the default calibration curve for sample result calculation in the related art, and realizing flexible selection of the default calibration curve.

[0075] The present application also provides a sample analysis system, including a sample analyzer, wherein the sample analyzer is provided with a device for selecting a default calibration curve as described in the above embodiment. With the sample analysis system of the present invention, flexible selection of a default calibration curve can be achieved, and the concentration of a reagent of the same type as the sample reagent of unknown concentration can be tested more accurately.

[0076] Accordingly, the present application also provides an electronic device, see Figure 4 , the electronic device 300 includes a memory 301 and a processor 302.

[0077] The processor 302 may be a central processing unit (CPU), or other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field-programmable gate arrays (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. A general-purpose processor may be a microprocessor or the processor may be any conventional processor, etc.

[0078] The memory 301 may include various types of storage units, such as system memory, read-only memory (ROM) and permanent storage devices. Among them, ROM can store static data or instructions required by the processor 302 or other modules of the computer. The permanent storage device may be a readable and writable storage device. The permanent storage device may be a non-volatile storage device that does not lose the stored instructions and data even after the computer is powered off. In some embodiments, the permanent storage device uses a large-capacity storage device (such as a magnetic or optical disk, flash memory) as a permanent storage device. In some other embodiments, the permanent storage device may be a removable storage device (such as a floppy disk, an optical drive). The system memory may be a readable and writable storage device or a volatile readable and writable storage device, such as a dynamic random access memory. The system memory may store some or all instructions and data required by the processor at run time. In addition, the memory 301 may include any combination of computer-readable storage media, including various types of semiconductor memory chips (such as DRAM, SRAM, SDRAM, flash memory, programmable read-only memory), and disks and / or optical disks may also be used. In some embodiments, the memory 301 may include a readable and / or writable removable storage device, such as a laser disc (CD), a read-only digital versatile disc (such as a DVD-ROM, a double-layer DVD-ROM), a read-only Blu-ray disc, an ultra-density optical disc, a flash memory card (such as an SD card, a mini SD card, a Micro-SD card, etc.), a magnetic floppy disk, etc. Computer-readable storage media do not include carrier waves and transient electronic signals transmitted wirelessly or wired.

[0079] The memory 301 stores executable codes, and when the executable codes are processed by the processor 302 , the processor 302 can execute part or all of the methods described above.

[0080] In addition, the method according to the present application may also be implemented as a computer program or a computer program product, which includes computer program code instructions for executing some or all of the steps in the above method of the present application.

[0081] Alternatively, the present application can also be implemented as a computer-readable storage medium (or non-transitory machine-readable storage medium or machine-readable storage medium) on which executable code (or computer program or computer instruction code) is stored. When the executable code (or computer program or computer instruction code) is executed by a processor of an electronic device (or server, etc.), the processor executes part or all of the steps of the above-mentioned method according to the present application.

[0082] The embodiments of the present application have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or improvements to the technology in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A method for selecting a default calibration curve, characterized in that: Displaying a list of multiple calibration curves for detection reagents on a display device of a sample analyzer, wherein the sample analyzer includes a sample loading mechanism and a reagent loading mechanism, the sample loading mechanism can load a sample to be tested, the reagent loading mechanism can accommodate a reagent kit required for each detection item, and the reagent kit contains a detection reagent; In response to a selection operation on a calibration curve in the list, determining a target calibration curve according to the selection operation; The target calibration curve is set as the current default calibration curve, wherein the sample analyzer calculates the concentration data of the sample to be tested with the help of the default calibration curve when obtaining the detection signal.

2. The method according to claim 1, characterized in that: The multiple calibration curves displayed by the display device are obtained after multiple calibration tests are performed on at least the same batch of detection reagents in the sample analyzer.

3. The method according to claim 1, characterized in that Determining the target calibration curve according to the selection operation includes: Determining the distances between the plurality of calibration curves in the list and each calibration concentration point, and sorting the plurality of calibration curves according to the distances; According to the selection operation, the calibration curve closest to each calibration concentration point is determined as the target calibration curve.

4. The method according to claim 1, characterized in that: Determining the target calibration curve according to the selection operation includes: The distances between the multiple calibration curves in the list and the respective calibration concentration points are determined. If the distances are greater than a set deviation threshold, the calibration curve corresponding to the adjacent batch of the detection reagent to the current batch of the detection reagent is determined as the target calibration curve according to the selection operation.

5. The method according to claim 1, characterized in that The setting the target calibration curve as a default calibration curve comprises: Determining whether the target calibration curve is valid; If it is valid and within the validity period, the target calibration curve is determined as the current default calibration curve.

6. The method according to claim 1, characterized in that Before setting the target calibration curve as the current default calibration curve, the method includes: It is determined whether there is an initial default calibration curve in the sample analyzer. If so, the initial default calibration curve is set as a non-default calibration curve, and the target calibration curve is set as a current default calibration curve.

7. A device for selecting a default calibration curve, characterized in that: include: A calibration display module, used to display a list of multiple calibration curves for detection reagents on a display device of the sample analyzer; wherein the sample analyzer includes a sample loading mechanism and a reagent loading mechanism, the sample loading mechanism is used to load the sample to be tested, the reagent loading mechanism can accommodate the reagent kit required for each detection item, and the reagent kit contains the detection reagent; A first processing module, configured to respond to a selection operation on a calibration curve in the list and determine a target calibration curve according to the selection operation; The second processing module is used to set the target calibration curve as the current default calibration curve, wherein the sample analyzer calculates the concentration data of the sample to be tested with the help of the default calibration curve when obtaining the detection signal.

8. The device according to claim 7, characterized in that The first processing module comprises: A distance determination submodule, used to determine the distances between the plurality of calibration curves in the list and each calibration concentration point; The curve selection submodule is used to sort the error values ​​corresponding to the multiple calibration curves, and determine the calibration curve with the smallest error value as the target calibration curve according to the selection operation.

9. A sample analysis system, characterized in that: It comprises a sample analyzer, wherein the sample analyzer is provided with the device as claimed in any one of claims 7-8.

10. An electronic device, characterized in that: include: processor; as well as A memory having executable codes stored thereon, which, when executed by the processor, causes the processor to execute the method according to any one of claims 1 to 6.

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