Ramelteon liquid preparation as well as preparation method and application thereof
By developing a liquid preparation of rametamine administered through mucosal administration, the solubility is improved by using specific solvents and solubilizers, and the stability is ensured through the mixed solvent composed of specific components, the problems of low bioavailability and inconvenience in drug use are solved, achieving efficient and stable drug absorption and good drug use experience.
CN119950417APending Publication Date: 2025-05-09HUNAN HUIZE BIO PHARMA CO LTD
1 Cites 1 Cited by
Patent Information
- Application Number
- CN202411488607.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-11-09
- Filing Date
- 2024-10-23
- Publication Date
- 2025-05-09
AI Technical Summary
Technical Problem
The water insoluble in rametamine leads to low bioavailability, slow absorption of oral preparations in the human body, and the existing sublingual preparations are inconvenient to use, affecting patient compliance.
Method used
A liquid preparation of rametamine administered through mucosal administration is developed. By selecting specific types of composite solvents and solubilizers, the solubility of rametamine in water is improved, and the stability of the preparation is ensured through a mixed solvent composed of specific components.
Benefits of technology
It improves the bioavailability of rametiramine, shortens absorption time, enhances the stability and storage value of the preparation, and improves the patient's medication experience and compliance.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the field of pharmaceutical preparations, in particular to a ramelteon liquid preparation as well as a preparation method and application thereof. The preparation comprises the following components: ramelteon, a first solvent, a second solvent and a third solvent, and optionally comprises one or more of water, a solubilizer, a surfactant, a polymer film-forming material, a plasticizer, a flavoring agent and a diluent. The preparation is high in stability, convenient to take and high in bioavailability, effectively overcomes the defects in the prior art, and has commercial application value.
Need to check novelty before this filing date? Find Prior Art