A biological sample preparation device

Abstract

The application provides a biological sample preparation device, and relates to the technical field of biological research. The biological sample preparation device is used for preparing a biological sample preparation, and comprises a slide positioning plate, a plurality of first positioning openings arranged in an array, each of the first positioning openings being used for placing a slide provided with a cover glass, and a sealing glue cutting assembly provided with a plurality of cutting pieces arranged in an array, each of the cutting pieces being matched with the profile of the cover glass. When the sealing glue cutting assembly is stacked on the slide positioning plate, the cutting pieces are arranged correspondingly with the first positioning openings, and each of the cutting pieces cuts the solidified sealing glue at the edge of each cover glass. The biological sample preparation device provided by the application can improve the efficiency of preparation.

Description

Technical Field

[0001] This application relates to the field of biological research technology, and in particular to a biological sample preparation device. Background Technology

[0002] In micropaleontology research, the preparation of micropaleontological specimens helps to analyze and identify the characteristics of micropaleontological fossils in strata, thereby laying the foundation for inferring sedimentary environments and geological history, and helping to determine the distribution and scale of petroleum resources.

[0003] In preparing microfossil specimens (such as pollen and diatom specimens), the process begins by placing sample solutions (containing different biological cells) onto multiple glass slides. After the sample solutions on the slides are dried, the biological samples remain. Then, solid mounting adhesive is melted by heating and applied to the biological samples. Multiple coverslips are then placed on the slides one by one, adhering to the slides using the mounting adhesive. Once the mounting adhesive has cured, the specimen preparation process is complete.

[0004] To ensure a firm bond between the coverslip and the slide, a sufficient amount of mounting adhesive is applied to the slide. After the coverslip and slide are bonded, the mounting adhesive may overflow during biological sample preparation, requiring manual removal of the excess adhesive. This reduces the efficiency of biological sample preparation. Summary of the Invention

[0005] In view of the above problems, this application provides a biological sample preparation device that can improve the efficiency of sample preparation.

[0006] To achieve the above objectives, the embodiments of this application provide the following technical solutions:

[0007] This application provides a biological sample preparation apparatus for preparing biological sample slides. The biological sample preparation apparatus includes:

[0008] A glass slide positioning plate has multiple first positioning ports arranged in an array, and each first positioning port is used to place a glass slide covered with a cover glass slide.

[0009] The cover glass adhesive cutting assembly is provided with multiple cutting elements arranged in an array, each of which matches the contour of the cover glass slide;

[0010] When the sealing adhesive cutting assembly is stacked on the glass slide positioning plate, the cutting element is positioned corresponding to the first positioning port, and each cutting element cuts the edge of each cover glass slide to cure the sealing adhesive.

[0011] In some embodiments of this application, at least one first connector is provided on the first side of the slide positioning plate, and at least one second connector is provided on the side of the sealing adhesive cutting assembly corresponding to the first connector;

[0012] The first connector and the second connector are detachably and rotatably connected.

[0013] In some embodiments of this application, the sealing adhesive cutting assembly is provided with a cutting handle, which is located on the side of the sealing adhesive cutting assembly corresponding to the second side of the glass slide positioning plate;

[0014] Move the cutting handle away from or near the slide positioning plate, causing one side of the sealing adhesive cutting assembly to move away from or near the slide positioning plate.

[0015] In some embodiments of this application, the sealing adhesive cutting assembly array has multiple second positioning ports arranged in a manner;

[0016] When the sealing adhesive cutting assembly is stacked on the glass slide positioning plate, each second positioning port corresponds to each first positioning port and their shapes match.

[0017] In some embodiments of this application, a support frame is included, the bottom of which is used to place a glass slide positioning plate;

[0018] The biological sample preparation device also includes a heated quantitative dispensing device, which is detachably connected to the support frame. The heated quantitative dispensing device is positioned above the slide positioning plate and is used to apply sealing adhesive to the slide.

[0019] At least one of the heated quantitative dispensing device and the glass slide positioning plate moves horizontally.

[0020] In some embodiments of this application, the heated quantitative dispensing device is provided with a receiving cavity, which contains solid sealing adhesive;

[0021] The inner wall of the receiving cavity is provided with a heating element, which heats the solid sealing adhesive to form a liquid sealing adhesive;

[0022] The receiving cavity is connected to the outlet of the heated metering dispenser, and the liquid sealing adhesive is dripped into the glass slide through the outlet.

[0023] In some embodiments of this application, the heated quantitative dispensing device is provided with an adjustment button, the adjustment button is connected to a valve plate, and the valve plate is rotatably located at the liquid outlet;

[0024] The adjustment button drives the valve plate to rotate around the central axis of the valve plate, controlling the gap between the valve plate and the liquid outlet, and changing the amount of liquid sealant dispensed.

[0025] In some embodiments of this application, the heated quantitative dispensing device is provided with a pressing head, and the pressing chamber inside the pressing head is in communication with the receiving chamber;

[0026] Pressing the press head causes the pressure chamber to change, forcing the liquid sealing adhesive to flow out of the outlet and drip into the glass slide.

[0027] In some embodiments of this application, the heated quantitative dispensing device is provided with a visualization window, through which the amount of liquid sealing adhesive in the receiving cavity can be observed.

[0028] In some embodiments of this application, the support frame includes a base, a vertical beam, a first horizontal beam, and a second horizontal beam. The vertical beam is vertically fixed to the base, the first horizontal beam is fixed to the top of the vertical beam, and the second horizontal beam is installed vertically to the first horizontal beam. The second horizontal beam reciprocates along the extension direction of the first horizontal beam.

[0029] When the heated metering dispenser is positioned on the second crossbeam, the heated metering dispenser moves back and forth along the extension direction of the second crossbeam.

[0030] This application provides a biological sample preparation apparatus, including a slide positioning plate and a slide positioning device. The slide positioning plate has multiple first positioning openings arranged in an array. A mounting adhesive cutting assembly has multiple cutting elements arranged in an array, each cutting element matching the contour of a coverslip. A slide, bonded to a coverslip, is placed on each of the first positioning openings, and then the mounting adhesive cutting assembly is stacked on top of the slide positioning plate, with the cutting elements corresponding to the positions of the coverslips. A force is applied to the mounting adhesive cutting assembly towards the slide positioning plate, and each cutting element cuts the cured mounting adhesive at the edge of each coverslip. By cutting the cured mounting adhesive at the edge of each coverslip, the cured mounting adhesive on all four sides of the coverslip can be removed. Furthermore, because the mounting adhesive cutting assembly has multiple cutting elements arranged in an array, the cured mounting adhesive of multiple biological sample preparations can be removed in one operation, thus improving the efficiency of biological sample preparation. Attached Figure Description

[0031] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0032] Figure 1 This is a schematic diagram of the structure of the slide positioning plate and the sealing adhesive cutting assembly provided in the embodiments of this application;

[0033] Figure 2 This is a schematic diagram of the structure of the biological sample preparation device provided in the embodiments of this application;

[0034] Figure 3 This is a schematic diagram of the structure of the heated quantitative dispensing device provided in the embodiments of this application.

[0035] Figure label:

[0036] 10 - Slide positioning plate;

[0037] 110 - First positioning port; 120 - First connecting piece;

[0038] 20-Sealing adhesive cutting assembly;

[0039] 210 - Cutting part; 220 - Second connecting part; 230 - Second positioning port;

[0040] 30-Support frame;

[0041] 310 - Base; 320 - Vertical beam; 330 - First horizontal beam; 340 - Second horizontal beam;

[0042] 40 - Heated metering dispenser;

[0043] 410 - Receiving cavity; 420 - Liquid outlet; 430 - Adjustment button; 440 - Pressing head; 450 - Visual window; 451 - Scale line; 452 - Pointer; 453 - Window switch. Detailed Implementation

[0044] As described in the background section, related technologies require the simultaneous preparation of multiple micro-paleontological sample slides (such as those for pollen and diatoms) for micro-paleontological research. First, a sample solution (containing different biological cells) is dropped onto multiple glass slides. Then, the sample solutions on the slides are dried, leaving the biological samples. Next, solid mounting adhesive is heated and melted to form a liquid mounting adhesive, which is then dropped onto the samples. Subsequently, multiple coverslips are sequentially placed on the glass slides, adhering them to the slides using the liquid mounting adhesive. After the liquid mounting adhesive cures, the biological sample preparation process is complete.

[0045] To ensure a firm bond between the coverslip and the slide, a sufficient amount of liquid mounting adhesive is applied to the slide. After the coverslip and slide are bonded, the liquid mounting adhesive may overflow during biological sample preparation. To ensure a strong bond between the coverslip and slide, the overflowing and cured mounting adhesive needs to be manually removed one by one after it has cured. Manually removing the overflowing and cured mounting adhesive is time-consuming, thus reducing the efficiency of biological sample preparation.

[0046] In view of this, the biological sample preparation apparatus provided in this application includes a slide positioning plate and a slide positioning device. The slide positioning plate has multiple first positioning openings arranged in an array. The sealing adhesive cutting assembly has multiple cutting elements arranged in an array, each cutting element matching the contour of a coverslip. A slide, after being bonded to a coverslip, is placed on each of the first positioning openings, and then the sealing adhesive cutting assembly is stacked on top of the slide positioning plate, with the cutting elements corresponding to the positions of the coverslips. When the sealing adhesive cutting assembly applies a force toward the slide positioning plate, each cutting element cuts the cured sealing adhesive at the edge of each coverslip. By cutting the cured sealing adhesive at the edge of each coverslip, the cured sealing adhesive on all four sides of the coverslip can be removed. Furthermore, because the sealing adhesive cutting assembly has multiple cutting elements arranged in an array, the cured sealing adhesive of multiple biological sample preparations can be removed at once, thus improving the efficiency of biological sample preparation.

[0047] To make the above-mentioned objectives, features, and advantages of the embodiments of this application more apparent and understandable, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of this application, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0048] This application provides a biological sample preparation apparatus for producing biological sample slides. Biological sample preparation refers to the process of preparing biological samples into microscope slides for observation, facilitating subsequent research and analysis. For example, microfossils such as pollen and diatoms can be prepared into biological sample slides to analyze sedimentary environments and geological history.

[0049] Biological sample preparation uses glass slides as the carrier of biological samples. Slides are divided into glass slides and coverslips. Glass slides can be rectangular glass or quartz slides, offering good light transmission. Glass slides are typically thicker and larger than coverslips. Coverlips can be square or rectangular glass slides. Their good light transmission ensures clear observation of the sample under a microscope. In biological sample preparation, glass slides are typically used to hold the biological sample, and coverslips are typically used to cover the biological sample on the glass slide.

[0050] Before placing the coverslip onto the slide, a drop of mounting adhesive needs to be applied to the slide. The mounting adhesive is used to seal and protect the biological sample on the slide, and it also helps to bond the coverslip to the slide. Common mounting adhesives include resins and glycerin gelatin.

[0051] Among these, resins typically include neutral resin, fir resin, and rosin. These three types of glue are relatively inexpensive and suitable for large-scale experimental operations such as geological surveys. Neutral resin is a liquid, but its pungent odor is harmful to health. Fir resin and rosin are natural resins, harmless to human health, and suitable for large-scale use. However, fir resin and rosin are mostly solid at room temperature and need to be melted before use.

[0052] Reference Figure 1 As shown, the biological sample preparation apparatus provided in this application embodiment includes a slide positioning plate 10. The slide positioning plate 10 has multiple first positioning openings 110 arranged in an array, each first positioning opening 110 being used to place a slide. This arrangement allows multiple slides or multiple glued coverslips and slides to be placed neatly and orderly, facilitating subsequent slide preparation operations.

[0053] Furthermore, each of the first positioning openings 110 can be configured as a shallow recess, into which the slide can be embedded. This prevents the slide from moving when liquid mounting adhesive is applied, thus preventing it from dripping outside the slide and wasting the liquid mounting adhesive.

[0054] For example, multiple first positioning ports 110 are arranged in an array of two rows and ten columns. This arrangement can accommodate twenty glass slides at the same time, which helps to improve slide preparation efficiency.

[0055] The biological sample preparation apparatus provided in this application includes a mounting adhesive cutting assembly 20. The mounting adhesive cutting assembly 20 is provided with a plurality of arrayed cutting elements 210, each cutting element 210 matching the contour of a coverslip. After the coverslip is placed on the slide, any excess cured mounting adhesive can be removed by the cutting elements 210.

[0056] For example, the cutter 210 can be a square blade, the cutting edge of which can cut off excess cured sealant. The square size of the blade is slightly larger than the outer contour of the coverslip to ensure that the cutter 210 can completely cover and cut into the cured sealant at the edge of the coverslip.

[0057] When the sealing adhesive cutting assembly 20 is stacked on the slide positioning plate 10, the cutting element 210 is positioned corresponding to the first positioning opening 110. That is, the slides bonded to the coverslips are placed on the respective first positioning openings 110, and the sealing adhesive cutting assembly 20 is stacked on the slide positioning plate 10, with the cutting element 210 corresponding to the position of the coverslip. A force is applied to the sealing adhesive cutting assembly 20 toward the slide positioning plate 10, causing the cutting element 210 to cut and cure the sealing adhesive at the edges of each coverslip.

[0058] By cutting the cured sealing adhesive at the edges of each coverslip using the cutting element 210, the cured sealing adhesive on all four sides of the coverslip can be removed in one go. This improves the efficiency of biological sample preparation. The sealing adhesive cutting assembly 20 is equipped with multiple arrayed cutting elements 210, allowing the removal of cured sealing adhesive from multiple biological sample slides at once, thus further improving the efficiency of biological sample preparation.

[0059] The cutter 210 is shaped to match the contour of the coverslip, allowing for precise removal of cured sealant from multiple edges of the coverslip. When the cutter 210 is applied to the coverslip, it does not damage the coverslip itself or the biological sample on the slide, improving the consistency and accuracy of biological sample preparation. Furthermore, this design eliminates the need for manual removal of cured sealant, preventing accidental hand injury when handling the cutter 210.

[0060] Reference Figure 2 As shown, the biological sample preparation apparatus provided in this application includes a support frame 30. The bottom of the support frame 30 is used to place a slide positioning plate 10. For example, a base 310 is provided at the bottom of the support frame 30, and the slide positioning plate 10 is placed on the base 310. The slide positioning plate 10 can be fixed to the base 310 by adhesive or the like to assist in the subsequent slide preparation process.

[0061] The biological sample preparation apparatus provided in this application also includes a heated quantitative dispensing device 40. The heated quantitative dispensing device 40 is used to dispense a quantitative amount of liquid mounting adhesive onto the glass slide. The heated quantitative dispensing device 40 ensures that a fixed amount of mounting adhesive is dispensed onto the glass slide each time, thereby reducing the possibility of dispensing excessive mounting adhesive, decreasing the probability of overflowing mounting adhesive, eliminating the need to handle overflowing mounting adhesive, and improving slide preparation efficiency. The quantitative dispensing of mounting adhesive also reduces waste and lowers the cost of biological sample preparation.

[0062] The heated quantitative dispensing device 40 can directly dispense a measured amount of liquid sealing adhesive onto the slide. When the slide positioning plate 10 is placed at the bottom of the support frame 30, the heated quantitative dispensing device 40 can also be fixed at the top of the support frame 30, allowing the heated quantitative dispensing device 40 to directly dispense liquid sealing adhesive onto the slide on the slide positioning plate 10. Therefore, the heated quantitative dispensing device 40 and the support frame 30 are detachably connected. This design improves the applicability of the heated quantitative dispensing device 40.

[0063] For example, the detachable connection between the support frame 30 and the heated metering dispenser 40 can be configured as a snap-fit ​​connection, facilitating the removal of the heated metering dispenser 40 from the support frame 30. Alternatively, the detachable connection between the support frame 30 and the heated metering dispenser 40 can be configured as a screw-and-threaded connection, where the heated metering dispenser 40 is securely fixed by screws.

[0064] When the heated metering dispenser 40 is positioned above the slide positioning plate 10, the slide is placed in the first positioning opening 110, and sealing adhesive can be dispensed onto the slide by the heated metering dispenser 40. After the sealing adhesive is dispensed onto the slide by the heated metering dispenser 40, a coverslip can be placed on the slide. Next, after the coverslip and slide are bonded together, the sealing adhesive cutting assembly 20 is stacked on the slide positioning plate 10, and the excess cured sealing adhesive is cut off by the cutting element 210.

[0065] In some embodiments, the heated metering dispenser 40 and the slide positioning plate 10 can move in two directions, horizontal and vertical. This arrangement increases the application range of the sealing adhesive, allowing it to be applied to each slide on the slide positioning plate 10, thereby improving slide preparation efficiency.

[0066] For example, the support frame 30 has a first slide rail at its bottom, on which a slide positioning plate 10 is fixed. The slide positioning plate 10 can move along the extension direction of the first slide rail. The support frame 30 also has a second slide rail at its bottom, perpendicular to the first slide rail. A heated quantitative dispensing device 40 is fixed to the second slide rail. The heated quantitative dispensing device 40 can move along the second slide rail, and the slide positioning plate 10 can move along the first slide rail. This configuration allows the heated quantitative dispensing device 40 to dispense liquid onto each slide of the slide positioning plate 10, increasing the dispensing range of the liquid mounting adhesive.

[0067] In other embodiments, one of the heated metering dispenser 40 and the slide positioning plate 10 moves in two directions within the horizontal plane. Similarly, this increases the application range of the mounting adhesive.

[0068] For example, the support frame 30 includes a base 310, a vertical beam 320, a first horizontal beam 330, and a second horizontal beam 340. The bottom of the vertical beam 320 is vertically fixed to the base 310. The first horizontal beam 330 is laterally fixed to the top of the vertical beam 320. The second horizontal beam 340 is installed perpendicularly to the first horizontal beam 330. A heated metering dispenser 40 can be installed on the second horizontal beam 340. The second horizontal beam 340 reciprocates along the extension direction of the first horizontal beam 330, so that the heated metering dispenser 40 reciprocates in a direction parallel to the first horizontal beam 330. Furthermore, the heated metering dispenser 40 reciprocates along the extension direction of the second horizontal beam 340. The heated metering dispenser 40 can dispense liquid onto each slide of the slide positioning plate 10 to improve slide preparation efficiency.

[0069] For example, the heated metering dispenser 40 has gear teeth on its outer side, and the second crossbeam 340 has a meshing rack. Through the cooperation of the gear and the rack, the heated metering dispenser 40 can achieve reciprocating movement.

[0070] Reference Figure 3 As shown, the heated quantitative liquid dispenser 40 is provided with a receiving cavity 410, and a heating element is provided on the inner wall of the receiving cavity 410. The heating element can heat the object inside the receiving cavity 410.

[0071] For example, the heating element can be configured as a heating wire, which is evenly wound around the inner wall of the receiving cavity 410 to improve the uniformity of heating. In addition, a heat insulation layer is provided on the outer side of the receiving cavity 410 to prevent heat loss.

[0072] Solid sealing adhesive is added into the receiving cavity 410, and the solid sealing adhesive in the receiving cavity 410 is heated by the heating unit to form liquid sealing adhesive. This allows a fixed amount of liquid sealing adhesive to be directly dispensed onto the glass slide, which improves the applicability of the heated metering dispenser 40.

[0073] The heated quantitative liquid dispenser 40 is provided with a liquid outlet 420, which is connected to the receiving cavity 410. Liquid sealing adhesive is dripped into the glass slide through the liquid outlet 420.

[0074] For example, the outlet 420 is located on the lower side of the heated metering dispenser 40 so that the heated metering dispenser 40 can flow out liquid sealing adhesive more smoothly.

[0075] The heated quantitative liquid dispenser 40 can be equipped with a power plug, which provides energy to the heating unit by inserting the plug into the socket.

[0076] A portion of the receiving cavity 410 of the heated metering dispenser 40 can be configured as a viewing window 450. By observing the viewing window 450, the volume of liquid sealing adhesive within the receiving cavity 410 can be determined. The viewing window 450 can be hinged, allowing the receiving cavity 410 to be opened. This allows for the addition of solid sealing adhesive to the receiving cavity 410, ensuring sufficient adhesive volume and preventing flow interruptions. For example, the viewing window 450 can be a transparent acrylic window, which can reduce the cost of the heated metering dispenser 40.

[0077] The visualization window 450 may also be equipped with a window switch 453, which can be used to open the visualization window 450 to facilitate the addition of solid sealing adhesive into the receiving cavity 410. For example, the window switch 453 may be configured as a rotary latch, which closes the receiving cavity 410 by locking the visualization window 450.

[0078] The heated quantitative dispensing device 40 is equipped with an adjustment button 430, which is used to adjust the dispensing volume of liquid sealing adhesive. By rotating the adjustment button 430, the dispensing volume of liquid sealing adhesive can be adjusted to prevent excessive liquid sealing adhesive from being added to the slide, causing the liquid sealing adhesive to overflow after the coverslip is placed on top, thus reducing the efficiency of slide preparation. In some embodiments, the heated quantitative dispensing device 40 is connected to a valve plate, which is rotatably disposed at the dispensing port 420.

[0079] Adjusting button 430 drives the valve plate to rotate around its central axis, thereby controlling the gap between the valve plate and the outlet 420, changing the flow area of ​​the liquid sealant, and thus changing the amount of liquid sealant dispensed. For example, the valve plate can be configured as a butterfly valve, which is simple in structure and easy to install.

[0080] The adjustment button 430 can be located on the outer wall of the receiving cavity 410 for easy operation by the operator.

[0081] In addition, the visualization window 450 has a scale line 451 and a pointer 452 printed on it. The pointer 452 can be adjusted by adjusting the button 430 to indicate different scales on the scale line 451, and the amount of liquid sealing adhesive flowing out can be adjusted according to the scale value on the scale line 451.

[0082] For example, through multiple comparative experiments, a one-to-one correspondence was established between the angle of rotation of the valve disc around its central axis and the scale line 451. The pointer 452 can be set to slide, and the adjustment button 430 is connected to the pointer 452 via a linkage. When the adjustment button 430 rotates, the rotation angle of the valve disc also changes, and the position of the pointer 452 on the scale line 451 changes accordingly, allowing the liquid output to be adjusted based on the scale value on the scale line 451.

[0083] The heated quantitative dispensing device 40 is also equipped with a pressing head 440. The pressing head 440 has a pressing chamber (not shown in the figure) that is connected to the receiving chamber 410.

[0084] Pressing the pressing head 440 changes the volume of the pressing chamber, forcing liquid sealing adhesive to flow out of the outlet 420 and drip onto the glass slide. For example, the pressing head 440 can be made of rubber to allow the liquid sealing adhesive to flow out. Furthermore, the pressing head 440 is provided with a connecting hole between the pressing chamber and the outside, so that the pressing head 440 can return to its original state after being pressed.

[0085] The pressing head 440 is located on the upper part of the receiving cavity 410 for easy operation by the operator.

[0086] Reference Figure 1As shown, in some embodiments, one side of the wide edge of the slide positioning plate 10 is designated as the first side of the slide positioning plate, and the first side of the slide positioning plate is provided with one or more first connectors 120. The sealing adhesive cutting assembly 20 is provided with at least one second connector 220. When the sealing adhesive cutting assembly 20 is stacked on the slide positioning plate 10, the first connector 120 and the second connector 220 are positioned correspondingly, and the first connector 120 and the second connector 220 are detachably and rotatably connected.

[0087] For example, the first connector 120 and the second connector 220 can be configured as a hinge. The hinge enables the first connector 120 and the second connector 220 to be rotatably connected.

[0088] For example, the first connector 120 and the second connector 220 can be configured as a pin and a hole that mates with it. The first connector 120 and the second connector 220 are rotatably connected through the engagement of the pin and the hole.

[0089] In some embodiments, the second side of the slide positioning plate 10 is opposite to the first side of the slide positioning plate, and the sealing adhesive cutting assembly 20 has a cutting handle on the side corresponding to the second side of the slide positioning plate.

[0090] By holding the cutting handle and applying a force away from or close to the slide positioning plate 10, one side of the sealing adhesive cutting assembly 20 can be moved away from or close to the slide positioning plate 10 to cut off the overflowing cured sealing adhesive.

[0091] For example, the first side of the slide positioning plate 10 is rotatably connected to the sealing adhesive cutting assembly 20. By applying a force close to the slide positioning plate 10 to the cutting handle, the second side of the sealing adhesive cutting assembly 20 can be moved close to the slide positioning plate 10, thereby cutting off the excess cured sealing adhesive. This arrangement utilizes the lever principle, making the operation of cutting off the excess cured sealing adhesive more effortless.

[0092] In some embodiments, the adhesive sealing cutter assemblies 20 are arrayed with multiple second positioning openings 230. When the adhesive sealing cutter assemblies 20 are stacked on the slide positioning plate 10, each second positioning opening 230 corresponds one-to-one with each first positioning opening 110 and their shapes are matched. The shape-matched second positioning openings 230 provide additional support, making the adhesive sealing cutter assemblies 20 more stable under force during the cutting process.

[0093] The various embodiments or implementation methods described in this specification are presented in a progressive manner. Each embodiment focuses on the differences from other embodiments, and the same or similar parts between the embodiments can be referred to each other.

[0094] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with an embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0095] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A biological sample preparation apparatus for preparing biological sample slides, characterized in that, The biological sample preparation device includes: The slide positioning plate (10) has multiple first positioning ports (110) arranged in an array, and each first positioning port (110) is used to place a slide covered with a cover glass. The cover glass cutting assembly (20) is provided with multiple arrayed cutting elements (210), each of which matches the outline of the cover glass. When the sealing adhesive cutting assembly (20) is stacked on the glass slide positioning plate (10), the cutting element (210) is correspondingly set with the first positioning port (110), and each cutting element (210) cuts the sealing adhesive at the edge of each cover glass slide; The slide positioning plate (10) has at least one first connector (120) on its first side, and the sealing adhesive cutting assembly (20) has at least one second connector (220) on the side corresponding to the first connector (120). The first connector (120) and the second connector (220) are detachably connected; The sealing adhesive cutting assembly (20) has multiple second positioning ports (230) arranged in an array. When the sealing adhesive cutting assembly (20) is stacked on the glass slide positioning plate (10), each of the second positioning ports (230) corresponds to each of the first positioning ports (110) and their shapes match.

2. The biological sample preparation device according to claim 1, characterized in that, The sealing adhesive cutting assembly (20) is provided with a cutting handle, which is located on the side of the sealing adhesive cutting assembly (20) corresponding to the second side of the slide positioning plate (10); The cutting handle moves away from or near the slide positioning plate (10), causing one side of the sealing adhesive cutting assembly (20) to move away from or near the slide positioning plate (10).

3. The biological sample preparation device according to claim 1 or 2, characterized in that, include: A support frame (30) is provided at the bottom for placing the slide positioning plate (10). The biological sample preparation device also includes a heated quantitative liquid dispenser (40), which is detachably connected to the support frame (30). The heated quantitative liquid dispenser (40) is positioned above the slide positioning plate (10) and is used to dispense sealing adhesive onto the slide. At least one of the heated quantitative dispensing device (40) and the glass slide positioning plate (10) moves in the horizontal direction.

4. The biological sample preparation device according to claim 3, characterized in that, The heated quantitative dispensing device (40) is provided with a receiving cavity (410), which contains solid sealing adhesive; The inner wall of the receiving cavity (410) is provided with a heating part, which heats the solid sealing adhesive to form a liquid sealing adhesive; The receiving cavity (410) is connected to the outlet (420) of the heated quantitative liquid dispenser (40), and the liquid sealing adhesive is dripped into the glass slide through the outlet (420).

5. The biological sample preparation device according to claim 4, characterized in that, The heated quantitative liquid dispenser (40) is equipped with an adjustment button (430), and the adjustment button (430) is connected to a valve plate, which is rotatably located at the liquid outlet (420). The adjustment button (430) drives the valve plate to rotate around the central axis of the valve plate, controls the gap between the valve plate and the liquid outlet (420), and changes the liquid output of the liquid sealing adhesive.

6. The biological sample preparation apparatus according to claim 4, characterized in that, The heated quantitative dispensing device (40) is provided with a pressing head (440), and the pressing chamber in the pressing head (440) is connected to the receiving chamber (410); Pressing the pressing head (440) causes the pressing chamber to change, forcing the liquid sealing adhesive to flow out from the outlet (420) and drip into the glass slide.

7. The biological sample preparation device according to claim 4, characterized in that, The heated quantitative dispensing device (40) is provided with a visualization window (450) through which the amount of liquid sealing adhesive in the receiving cavity (410) can be observed.

8. The biological sample preparation device according to claim 3, characterized in that, The support frame (30) includes a base (310), a vertical beam (320), a first crossbeam (330) and a second crossbeam (340). The vertical beam (320) is vertically fixed on the base (310), the first crossbeam (330) is fixed on the top of the vertical beam (320), and the second crossbeam (340) is installed vertically to the first crossbeam (330). The second crossbeam (340) reciprocates along the extension direction of the first crossbeam (330). When the heated metering dispenser (40) is disposed on the second crossbeam (340), the heated metering dispenser (40) reciprocates along the extension direction of the second crossbeam (340).

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