Traditional Chinese medicine composition for improving lung function as well as preparation method and application of traditional Chinese medicine composition
Through a traditional Chinese medicine composition containing Chinese medicine ingredients such as Astragalus, ginseng, Codonopsis, etc., the problems of lung dysfunction and pulmonary fibrosis after the infection of the new coronavirus were solved, and the effect of improving lung function and reducing side effects was achieved.
Patent Information
- Application Number
- CN202510257058.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-05
- Publication Date
- 2025-05-13
AI Technical Summary
After the new coronavirus infection, many people found lung nodules, lung imaging changes or lung fibrosis during the recovery period, resulting in symptoms such as cough, difficulty breathing, shortness of breath and fatigue. The existing treatment drugs are not effective and have great side effects, and there is a risk of improper use of traditional Chinese medicine treatment.
Provide a traditional Chinese medicine composition for improving lung function, including astragalus, ginseng, Codonopsis pilosula, five-finger peach, wolfberry, dried ginger and licorice, and is prepared by decoction and extraction, concentration under reduced pressure, spray drying and other processes.
This traditional Chinese medicine composition can effectively improve the symptoms of cough and shortness of breath after viral infection with pneumonia, and has the effect of treating pulmonary fibrosis. It is also highly safe because it uses raw materials that are of the same origin as medicine and food, and is suitable for use in a wide range of people.
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Abstract
Description
Technical Field
[0001] The present application relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for improving lung function, a preparation method thereof, and an application thereof. Background Art
[0002] After recovering from COVID-19 infection, most people have lung nodules after physical examinations, and some people occasionally have lung imaging changes. What is more alarming is that a small number of people show a trend of developing pulmonary fibrosis. Its external manifestations include coughing, labored breathing, shortness of breath, fatigue, dizziness, and palpitations, which not only affect the body's normal ability to move and the quality of life, but also bring potential risks to the health of this group of people.
[0003] After viral infection, the body's airway mucosa is damaged, and inflammation, edema, mucus plugging, smooth muscle spasm and other problems occur, causing the airway to narrow. During the recovery process, the body starts the repair mechanism, which may lead to excessive repair, affecting the normal ventilation and elasticity of the lungs, and then long-term manifestations such as weakened respiratory function. Or because the functional changes of small airways such as bronchioles may persist for a period of time, it is one of the reasons why patients still feel shortness of breath, cough and other symptoms after recovery. It is difficult to completely eliminate them.
[0004] There are currently a variety of therapeutic drugs for the recovery stage after viral pneumonia. However, the use of chemical drugs is not effective and is accompanied by many side effects and risks of adverse reactions. At the same time, there are some problems that cannot be ignored when using traditional Chinese medicine to treat the recovery period of viral pneumonia. Some traditional Chinese medicine treatment drugs either contain a variety of slightly toxic medicinal materials or have strict requirements for Chinese medicine syndrome differentiation. Once the medication is not accurately prescribed based on the results of the syndrome differentiation, it is easy to harm those who do not fully meet the indications for medication, which will affect the treatment effect and may even cause other adverse consequences.
[0005] Therefore, there is a need to provide a new therapeutic drug to improve lung function. Summary of the invention
[0006] In order to solve the above technical problems, the present application provides a Chinese medicine composition for improving lung function and a preparation method and application thereof.
[0007] In the first aspect, the present application provides a traditional Chinese medicine composition for improving lung function, specifically comprising the following components in parts by weight: 17-23 parts of astragalus, 7-13 parts of ginseng, 8-12 parts of codonopsis, 4-6 parts of quinquefolius, 17-23 parts of wolfberry, 9-11 parts of dried ginger, and 8-10 parts of licorice.
[0008] Preferably, the Chinese medicine composition for improving lung function specifically comprises the following components in parts by weight: 18-22 parts of astragalus, 8-12 parts of ginseng, 9-11 parts of codonopsis, 4.5-5.5 parts of quinquefolius, 18-22 parts of wolfberry, 9.5-10.5 parts of dried ginger, and 9-11 parts of licorice.
[0009] Preferably, the Chinese medicine composition for improving lung function specifically comprises the following components in parts by weight: 19-21 parts of astragalus, 9-11 parts of ginseng, 9.5-10.5 parts of codonopsis, 4.5-5.5 parts of quinquefolius, 19-21 parts of wolfberry, 9.5-10.5 parts of dried ginger, and 9.5-10.5 parts of licorice.
[0010] In a second aspect, the present application provides a traditional Chinese medicine preparation, characterized in that the traditional Chinese medicine preparation comprises an excipient and the traditional Chinese medicine composition according to any one of claims 1 to 4; the excipient is a pharmaceutical excipient or an edible excipient.
[0011] Preferably, the auxiliary material is selected from one or more of microcrystalline cellulose, magnesium stearate, gelatin, carrageenan, grass jelly powder, white sugar, and potassium sorbate.
[0012] Preferably, the Chinese medicine preparation is a solid Chinese medicine preparation or a liquid Chinese medicine preparation; the solid Chinese medicine preparation is selected from one or more of tablets, capsules, solid beverages, biscuits, and soft candies.
[0013] Preferably, when the Chinese medicine preparation is a tablet, the auxiliary material is selected from one or more of microcrystalline cellulose and magnesium stearate; when the Chinese medicine preparation is a soft candy, the auxiliary material is selected from one or more of gelatin, carrageenan, grass jelly powder, white sugar, and potassium sorbate.
[0014] In the third aspect, the present application provides a method for preparing the Chinese medicine preparation, which specifically includes the following steps in sequence: weigh the corresponding weight portions of each component raw material of astragalus, ginseng, codonopsis, quinoa, wolfberry, dried ginger, and licorice, respectively, add 11-13 times the amount of water, 11-13 times the amount of water, and 9-11 times the amount of water, respectively, and decoct and extract three times in sequence, each time for 100-140 minutes, filter, concentrate under reduced pressure, spray dry, crush, sieve, and add auxiliary materials to make a solid Chinese medicine preparation.
[0015] In a fourth aspect, the present application provides a method for preparing the Chinese medicine preparation, which specifically includes the following steps in sequence: weigh corresponding weight portions of each component raw material of astragalus, ginseng, codonopsis, quinoa, wolfberry, dried ginger, and licorice, add water and boil, boil and extract 3 times with 11-13 times the amount of water, 11-13 times the amount of water, and 9-11 times the amount of water in sequence, each time for 100-140 minutes, filter, concentrate under reduced pressure, prepare, and fill; add auxiliary materials to make a liquid Chinese medicine preparation.
[0016] The Chinese medicine composition involved in the present application can effectively treat symptoms such as cough, shortness of breath and fatigue in the late recovery period of viral pneumonia, and has a therapeutic effect on pulmonary fibrosis.
[0017] In the Chinese medicine composition involved in this application, only raw materials that are both medicinal and edible are selected for compatibility. It is worth mentioning that each of these raw materials has unique properties. They are both medicines that can play corresponding medicinal effects, help regulate the body and deal with diseases, and at the same time belong to the category of food, with high safety and can be eaten daily.
[0018] The efficacy of the Chinese medicine composition is relatively mild, and it will not cause excessive stimulation to the body, but it has a very good therapeutic effect. Because of this advantage, it is suitable for most people to take. While solving health problems for people, it can also avoid various hidden dangers caused by medication to a great extent, allowing users to use it with more confidence to improve their physical condition and restore their health.
[0019] The specific mechanism of the formula provided in this application is analyzed as follows: During the recovery period of COVID-19 infection, cough, labored breathing, shortness of breath, fatigue, dizziness, palpitations and other discomfort reactions often occur, and a small number of people show a trend of pulmonary fibrosis. Pulmonary fibrosis (PF) is a diffuse lung disease of unknown etiology that often involves the lung interstitium, alveoli and (or) bronchioles. It manifests as chronic, progressive, fibrotic interstitial pneumonia, and the clinical features are mainly irritating dry cough, progressive dyspnea and decreased lung function. Its cause is usually related to viral infection, smoking history, dust environment exposure and genetic factors.
[0020] Modern doctors usually classify the above clinical characteristics into the categories of "pulmonary consumption", "asthma", "pulmonary paralysis", "shortness of breath" and "consumption". The characteristics of the pathogenesis are deficiency of both qi and yin, accumulation of phlegm and blood stasis, and stagnation of qi and blood.
[0021] According to the principle of syndrome differentiation and treatment, this prescription uses Chinese medicine with the effects of nourishing the lungs and kidneys, resolving phlegm and unblocking collaterals, and promoting blood circulation and removing blood stasis. In this prescription, astragalus and ginseng are both the main medicines. Ginseng tastes sweet, slightly bitter, and slightly warm in nature. It belongs to the lung, spleen, and heart meridians. Ginseng is an important medicine for replenishing qi, which can greatly replenish vital energy. It has excellent therapeutic effects on various reasons such as long-term illness, physical weakness, and excessive fatigue, such as deficiency of vital energy and shortness of breath and fatigue. Astragalus tastes sweet, is slightly warm in nature, and belongs to the lung and spleen meridians. Astragalus has the effects of replenishing qi and raising yang, benefiting the body and consolidating the exterior. It has a strong power to replenish qi, and is good at replenishing lung qi and spleen qi. In the treatment of shortness of breath and fatigue, astragalus can help ginseng enhance the effect of replenishing qi, focusing on replenishing the qi of the lungs and spleen, so that the body's qi is sufficient and runs in an orderly manner. The lungs are responsible for qi and breathing, and the spleen is the source of qi and blood biochemical transformation. If the lung qi is sufficient, the breathing is smooth, and if the spleen qi is strong, the qi and blood biochemical transformation is active, which can better nourish the whole body and relieve fatigue caused by insufficient qi. The combination of ginseng and astragalus can jointly enhance the effect of replenishing qi and nourishing blood, one inside and one outside, to replenish the body's innate and acquired qi.
[0022] Codonopsis and five-fingered ginseng are both ministerial drugs. Codonopsis is sweet and mild in nature, and it belongs to the lung and spleen meridians. The effect of Codonopsis is similar to that of ginseng, but the medicinal effect is relatively slow. It can also nourish the spleen and lung qi, nourish blood and produce body fluid. In the prescription, it can assist the main medicine ginseng and astragalus to further nourish the qi of the lungs and spleen, play a synergistic effect, and make the qi-tonifying effect more comprehensive and lasting. In addition, Codonopsis is relatively mild, suitable for a wider range of people to take it for a long time to slowly recuperate the body, strengthen the physique, improve the symptoms such as shortness of breath, fatigue and weakness caused by weak lung qi and spleen qi, and make the qi-tonifying effect of the whole prescription more stable. Five-fingered ginseng is sweet in taste and slightly warm in nature. It belongs to the lung, spleen, stomach, large intestine, and liver meridians. It has the effects of strengthening the spleen and lungs, promoting qi and removing dampness, and relaxing muscles and activating collaterals. When treating shortness of breath and fatigue, its function of strengthening the spleen and tonifying the lungs can cooperate with the main and auxiliary medicines to enhance the nourishment of the lungs and spleen, optimize the biochemistry of qi and blood and the nourishment of lung qi, and improve shortness of breath and fatigue from the perspective of regulating organ function; at the same time, its effect of promoting qi and removing dampness can also avoid the disadvantages of qi stagnation and dampness caused by large amounts of qi supplementation, so that the supplemented qi can flow smoothly in the body and play a better role.
[0023] Wolfberry and dried ginger are adjuvants. Wolfberry is sweet and mild in nature, and belongs to the liver and kidney meridians. Wolfberry has the effect of nourishing the liver and kidney, improving the essence and improving eyesight. The liver and kidney are of the same origin. By nourishing the liver and kidney, the essence and blood can be sufficient, and the essence and blood can be transformed into qi, which indirectly plays the role of replenishing qi, assisting in enhancing the overall qi replenishing effect, and providing a more sufficient material basis for the generation of human qi; on the other hand, while replenishing qi in large quantities, it is necessary to prevent the situation where excess qi is fire. The yin-nourishing nature of wolfberry can restrain the possible dryness and heat, making the prescription as a whole tend to be peaceful, which is conducive to long-term use to regulate the symptoms of shortness of breath and fatigue, especially for long-term illness that consumes qi and damages yin or middle-aged and elderly people with insufficient qi and yin accompanied by shortness of breath and fatigue.
[0024] Dried ginger is pungent and hot in nature, and it enters the lung, spleen, and stomach meridians. Dried ginger has the effects of warming the middle and dispersing cold, restoring yang and unblocking meridians, and warming the lungs and transforming phlegm. It can dispel cold evil, invigorate yang, restore the normal function of the internal organs, assist the main and auxiliary drugs to better replenish qi, and make qi run more smoothly in the warm internal environment, improving symptoms such as shortness of breath, heaviness and fatigue caused by cold stagnation and qi stagnation; at the same time, the warm nature of dried ginger can also restrain the nourishing and greasy nature of drugs such as wolfberry, making the compatibility of the various drugs in the prescription more harmonious.
[0025] Licorice is a guiding drug. Licorice is sweet and mild in nature, and it enters the heart, lung, spleen, and stomach meridians. Licorice mainly plays the role of harmonizing the various drugs in this prescription. It can alleviate the medicinal properties of drugs such as ginseng and dried ginger, avoid conflicts between drugs or excessively strong medicinal properties, and make the efficacy of the entire prescription more stable and gentle. At the same time, licorice itself has the effects of invigorating qi and replenishing the middle, moistening the lungs and relieving coughs, relieving acute pain, etc. While harmonizing the various drugs, it also participates in replenishing qi and improving symptoms related to shortness of breath and fatigue, playing a role in auxiliary treatment.
[0026] In summary, each medicine in this prescription performs its respective function and cooperates with each other to jointly exert a therapeutic effect.
[0027] The effect of this prescription in treating lung deficiency cough and asthma: In traditional Chinese medicine, lung deficiency cough and asthma are mainly caused by insufficient lung qi and abnormal descending. In terms of treatment, the main method is to nourish qi and lungs. Commonly used Chinese medicines in clinical practice include ginseng, astragalus, and codonopsis. Ginseng has the effects of replenishing vital energy, nourishing the spleen and lungs, promoting fluid production, calming the mind and improving intelligence, and can be used to treat symptoms such as lung deficiency and asthma. Codonopsis has the effects of replenishing the middle qi and qi, promoting fluid production and nourishing blood, and replenishing the spleen and lungs. It has a certain therapeutic effect on symptoms such as weak lung qi, cough and asthma, and shortness of breath. In addition, lung deficiency cough and asthma are often accompanied by phlegm. Lung deficiency and phlegm can be treated with spleen-strengthening drugs, such as codonopsis. Lung deficiency and long-term cough can be treated with lung qi-replenishing Chinese medicine, ginseng, astragalus, licorice, etc.
[0028] The effect of this prescription on treating spleen and stomach qi deficiency: spleen and stomach qi deficiency can be manifested as loss of appetite, fatigue, loose stools and other symptoms. This prescription has a good therapeutic effect on spleen and stomach qi deficiency. Ginseng, astragalus, and codonopsis can replenish qi, promote fluid production and nourish blood, and nourish the spleen and lungs; licorice and five-fingered peach have the effects of replenishing qi and strengthening the spleen, and helping the spleen and stomach to transport and transform. They have a certain therapeutic effect on symptoms such as weakness in the limbs, weight loss, diarrhea, and sallow complexion caused by spleen deficiency and dampness. It helps to improve physical discomfort, gradually restore the balance and coordination of viscera functions, and improve overall health.
[0029] The effect of this prescription in treating pulmonary fibrosis: After 2 weeks of use, this prescription showed significant improvement in the lung function of mice and could alleviate the progression of pulmonary fibrosis.
[0030] In summary, the technical solution of this application has the following effects: The Chinese medicine composition provided in the present application only uses raw materials that are both medicinal and edible for combination; they are both medicines that can exert corresponding medicinal effects, help regulate the body and cope with diseases, and at the same time they belong to the category of food, are relatively safe, and can be consumed daily.
[0031] The Chinese medicine composition prescription provided in the present application is matched and combined by selecting specific types of drugs in specific dosages. Each drug in the prescription performs its own function and cooperates with each other to jointly exert a therapeutic effect. It has the effects of treating lung deficiency, cough and asthma, and spleen and stomach qi deficiency. It can also effectively treat cough, shortness of breath, fatigue and other symptoms associated with the late recovery period of viral pneumonia, and has a therapeutic effect on pulmonary fibrosis. DETAILED DESCRIPTION
[0032] The present application is further described in detail below in conjunction with examples, comparative examples and performance testing experiments. These examples should not be construed as limiting the scope of protection claimed in the present application. Example
[0033] Example 1 This embodiment provides a traditional Chinese medicine preparation.
[0034] The preparation method of the Chinese medicine preparation in this embodiment is: Take 20g of Astragalus, 10g of Ginseng, 10g of Codonopsis, 5g of Prunus mume, 20g of Lycium barbarum, 10g of Dry Ginger, and 10g of Licorice, weigh the raw materials in proportion, add 12 times of water, 12 times of water, and 10 times of water respectively, decoct and extract three times in sequence, each time for 2 hours, filter, concentrate under reduced pressure, spray dry, crush, sieve, and add auxiliary materials to make tablets. The addition method of auxiliary materials is: taking the chewable tablet specification of 2g / tablet as an example, the amount of magnesium stearate is 0.02g (equivalent to 1% of the total amount), stevioside is 0.01g (equivalent to 0.5% of the total amount), citric acid is 0.01g (equivalent to 0.5% of the total amount), and microcrystalline cellulose is supplemented to 2g (equivalent to 35% of the total amount).
[0035] Example 2 This embodiment provides a traditional Chinese medicine preparation.
[0036] The preparation method of the Chinese medicine preparation in this embodiment is: Take 20g of astragalus, 10g of ginseng, 10g of codonopsis, 5g of quinoa, 20g of wolfberry, 10g of dried ginger, and 10g of licorice, weigh the raw materials in proportion, add 12 times the amount of water, 12 times the amount of water, and 10 times the amount of water respectively, decoct and extract 3 times in sequence, each time for 2 hours, filter, concentrate under reduced pressure, spray dry, crush, and sieve, add 20% gelatin, 2% carrageenan, 9% grass jelly powder, 1% white sugar, and 1‰ potassium sorbate in an amount by weight to make soft candy.
[0037] Example 3 This embodiment provides a traditional Chinese medicine preparation.
[0038] The preparation method of the Chinese medicine preparation in this embodiment is: Take 20g of astragalus, 10g of ginseng, 10g of codonopsis, 5g of quinoa, 20g of wolfberry, 10g of dried ginger, and 10g of licorice, weigh the raw materials in proportion, add 12 times the amount of water, 12 times the amount of water, and 10 times the amount of water respectively, decoct and extract 3 times in sequence, each time for 2 hours, filter, and concentrate under reduced pressure, add flavoring agents (such as white sugar, xylitol and other sweeteners, flavors and fragrances, and potassium sorbate as a preservative) in an amount that meets the limit of GB2760, adjust the pH to 3-5 with citric acid-sodium citrate, add water to make up to volume, fill, and make a beverage.
[0039] Embodiment 4-9 Examples 4-9 each provide a traditional Chinese medicine preparation.
[0040] The difference between the above embodiment and embodiment 1 is that the dosage of each component in the traditional Chinese medicine preparation is different, as shown in Table 1.
[0041] Table 1 The dosage of each component in the Chinese medicine preparations in Examples 1, 4-9 The other process parameters in the above embodiment are the same as those in embodiment 1.
[0042] Comparative Example Comparative Examples 1-4 Comparative Examples 1-4 respectively provide a traditional Chinese medicine preparation.
[0043] The difference between the above comparative example and Example 1 is as follows.
[0044] In comparative example 1: an equal amount of Schisandra chinensis was used to replace ginseng.
[0045] In comparative example 2: an equal amount of Ophiopogon japonicus was used to replace Psoralea corylifolia.
[0046] In comparative example 3: an equal amount of cinnamon twigs was used to replace dried ginger.
[0047] In comparative example 4: liquorice was replaced with an equal amount of dried tangerine peel.
[0048] The other process parameters in the above comparative example are the same as those in Example 1.
[0049] Comparative Examples 5-6 Comparative Examples 5-6 each provide a traditional Chinese medicine preparation.
[0050] The difference between the comparative example and Example 1 is that the dosage of each component in the traditional Chinese medicine preparation is different, as shown in Table 1.
[0051] Table 2 The dosage of each component in the Chinese medicine preparation in Comparative Examples 5-6 The other process parameters in the above comparative example are the same as those in Example 1.
[0052] Performance testing Test methods 1. Experimental animals and groups Healthy male C57BL / 6 mice, SPF grade, 7-8 weeks old, body weight 20-25g. The animals were randomly divided into four groups: blank control group, model control group (BLM, intratracheal instillation of BLM 3mg / kg), low-dose and high-dose test drug groups (BLM + Chinese medicine preparation sample 0.2g (equivalent to crude drug) / kg, BLM + Chinese medicine preparation sample 0.4g (equivalent to crude drug) / kg).
[0053] 2. Experimental process The bleomycin (BLM) pulmonary fibrosis mouse model was established.
[0054] After 1 week of adaptive feeding, the mice were fasted for 12 hours before modeling, disinfected with iodine, and anesthetized with 2% sodium pentobarbital (40 mg / kg) by intraperitoneal injection. The mice were placed in a prone position, the upper incisors of the mice were fixed to open the mouth, and the tongue root was pressed with a tongue depressor. Bleomycin (3 mg / kg) was dripped into the lungs along the midline of the upper palate through the main bronchus. Immediately after the drip, the mice were erected and rotated along the longitudinal axis to evenly distribute the drug solution in both lungs, and the vital signs were observed and monitored. After the mice woke up, they were sent to the SPF observation room for routine feeding.
[0055] 24 hours after bleomycin modeling, each test drug group was gavaged with the drug according to the grouped dose, and the blank control group and the model control group were gavaged with the same volume of distilled water once a day for 14 consecutive days.
[0056] One day after the end of the administration, the samples were collected for testing. When collecting the samples, the animals were anesthetized with 2% sodium pentobarbital injected intraperitoneally, and the abdomen was opened after the animal's muscles relaxed and the corneal reflex disappeared. The lung function was first tested with an animal lung function instrument. After the lung function test was completed, blood and lungs were collected for subsequent testing.
[0057] (2) Experimental results (2.1) Basic information of animals Days 1-7 of drug administration: except for the blank control group, the mice in other groups lost weight, and the weight loss of mice in the model control group was particularly obvious. The mice were in poor condition, with bloodshot eyes, listlessness, reduced food intake, and shortness of breath. After days 4-7, the feeding activity of the test drug group gradually increased, the weight increased, and the shortness of breath was milder than that of the model control group.
[0058] On the 8th to 14th day of administration: the weight of mice in each group increased, and the increase in the model control group and the comparative group was smaller. The spirits of mice in each group treated with the Chinese medicine preparation prepared in the embodiment of the present application as the test drug improved, their hair was smoother, their breathing gradually became stable, their activities increased, and their food intake increased, especially in the test drug group.
[0059] (2.2) Histopathological examination The left lung was fixed with 4% formaldehyde solution, embedded after dehydration, and sliced for HE and Masson staining. Pathological changes such as lung tissue collagen deposition and lung tissue inflammation were observed under a microscope (blank control group comparison, model control group, and the Chinese medicine preparation prepared in Example 11 of the present application as the high-dose group of the test drug). The Szapiel score was used to evaluate alveolar inflammation, and the Ashcroft score was used to evaluate the severity of fibrosis.
[0060] Compared with the blank control group, the model control group mice had a large number of inflammatory cell infiltrations in the lung tissue, disordered alveolar structure, and ruptured alveolar walls; compared with the model control group, the lung tissue pathological morphology of the high-dose group of the Chinese medicine preparation prepared in the example of the present application as the test drug was significantly improved. Compared with the blank control group, the lung fibrosis score of the model control group mice was significantly increased; compared with the model control group, the lung fibrosis score of the high-dose group of the Chinese medicine preparation prepared in Example 1 of the present application as the test drug was significantly reduced.
[0061] This indicates that the test substance can effectively improve pulmonary fibrosis in mice.
[0062] (2.3) Pulmonary function test The BUXCO small animal respiratory lung function test system was used for testing, and the results are shown in Table 3.
[0063] Compared with the blank control group, the forced vital capacity (FVC) of mice in the model control group was significantly reduced; compared with the model control group, the FVC of each test drug group increased, and the parameters were close to those of the blank control group. This shows that the Chinese medicine preparation prepared in the embodiment of the present application can effectively maintain the lung function of mice as a test drug and slow down the decline in lung function caused by bleomycin sulfate.
[0064] (2.4) Determination of hydroxyproline (HYP) content in lung tissue The HYP content was determined using the HYP kit, and the results are shown in Table 3.
[0065] The results of HYP content determination showed that compared with the blank control group, the HYP content of the model control group showed an upward trend, with significant differences. Compared with the model control group, the Chinese medicine preparation prepared in the embodiment of the present application as a test drug has an effect on reducing the HYP content in the low-dose group, and the HYP content in the high-dose group has significantly decreased, and the effect is obviously more excellent.
[0066] This indicates that the test substance can effectively reduce the hydroxyproline content in the lungs of mice and effectively inhibit the development of pulmonary fibrosis in mice.
[0067] Table 3 Application performance test results of Chinese medicine preparations in Examples and Comparative Examples Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements may be made thereto based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.
Claims
1. A Chinese medicine composition for improving lung function, characterized in that: Specifically, the invention comprises the following components in parts by weight: 17-23 parts of astragalus, 7-13 parts of ginseng, 8-12 parts of codonopsis, 4-6 parts of quinquefolius, 17-23 parts of wolfberry, 9-11 parts of dried ginger and 8-10 parts of liquorice.
2. The Chinese medicine composition for improving lung function according to claim 1, characterized in that: Specifically, the invention comprises the following components in parts by weight: 18-22 parts of astragalus, 8-12 parts of ginseng, 9-11 parts of codonopsis, 4.5-5.5 parts of quinquefolius, 18-22 parts of wolfberry, 9.5-10.5 parts of dried ginger and 9-11 parts of liquorice.
3. The Chinese medicine composition for improving lung function according to claim 1, characterized in that: Specifically, the invention comprises the following components in parts by weight: 19-21 parts of astragalus, 9-11 parts of ginseng, 9.5-10.5 parts of codonopsis, 4.5-5.5 parts of quinquefolius, 19-21 parts of wolfberry, 9.5-10.5 parts of dried ginger and 9.5-10.5 parts of liquorice.
4. A Chinese medicine preparation, characterized in that: The Chinese medicine preparation comprises an auxiliary material and the Chinese medicine composition according to any one of claims 1 to 4; the auxiliary material is a pharmaceutical auxiliary material or an edible auxiliary material.
5. The Chinese medicine preparation according to claim 4, characterized in that: The auxiliary materials are selected from one or more of microcrystalline cellulose, magnesium stearate, gelatin, carrageenan, grass jelly powder, white sugar, and potassium sorbate.
6. The Chinese medicine preparation according to claim 4, characterized in that: The Chinese medicine preparation is a solid Chinese medicine preparation or a liquid Chinese medicine preparation; the solid Chinese medicine preparation is selected from one or more of tablets, capsules, solid beverages, biscuits, and soft candies.
7. The Chinese medicine preparation according to claim 4, characterized in that: When the Chinese medicine preparation is a tablet, the auxiliary material is selected from one or more of microcrystalline cellulose, magnesium stearate, and steviol glycosides; when the Chinese medicine preparation is a soft candy, the auxiliary material is selected from one or more of gelatin, carrageenan, grass jelly powder, white sugar, and potassium sorbate.
8. The method for preparing the Chinese medicine preparation according to any one of claims 4 to 7, characterized in that: Specifically, the following steps are performed in sequence: Weigh corresponding weight portions of astragalus, ginseng, codonopsis, quinquefolius, wolfberry, dried ginger and licorice respectively, add 11-13 times, 11-13 times and 9-11 times of water respectively, decoct and extract three times in sequence, each time for 100-140 minutes, filter, concentrate under reduced pressure, spray dry, crush and sieve, and add auxiliary materials to make a solid Chinese medicine preparation.
9. The method for preparing the Chinese medicine preparation according to any one of claims 4 to 7, characterized in that: Specifically, the following steps are performed in sequence: Weigh corresponding weight portions of astragalus, ginseng, codonopsis, quinquefolius, wolfberry, dried ginger and licorice respectively, add water for decoction, decoct and extract three times with 11-13 times, 11-13 times and 9-11 times water in sequence, each time for 100-140 minutes, filter, concentrate under reduced pressure, prepare and fill; add auxiliary materials to make a liquid Chinese medicine preparation.