Antibacterial and anti-inflammatory preparation with tackifying and moisturizing effects

Abstract

The invention discloses an antibacterial and anti-inflammatory preparation with tackifying and moisturizing effects. The preparation at least contains an antibacterial component, a non-antibiotic anti-inflammatory component and a tackifying and moisturizing component, wherein the antibacterial component is a component containing effective iodine; the non-antibiotic anti-inflammatory component is one or a combination of glycyrrhizic acid compounds; the tackifying and moisturizing component comprises one or a combination of more of glycerol and cellulose substances. When the preparation is used, the tackifying and moisturizing component can increase the adhesive force of the preparation and reduce the loss speed of water in the preparation, so that the purposes of tackifying and moisturizing are achieved, and the acting time of the preparation acting on a treatment part is effectively prolonged; the effective iodine can play a bactericidal role, meanwhile, the glycyrrhizic acid compounds play a continuous anti-inflammatory role to prevent inflammation expansion and shorten the duration time of inflammation, and compared with an original treatment technology, the preparation can improve the treatment efficiency of infected wounds.

Description

Technical Field

[0003] The invention belongs to the field of infection treatment preparations, and in particular relates to an antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects. Background Art

[0005] The invention of application number 2024115614419: a preparation with antibacterial and anti-inflammatory effects, which has good effects when tested under ideal test conditions for its bactericidal efficiency, but when sprayed on the surface of the pharyngeal mucosa in actual use, if the spraying amount is slightly too much, the droplets will condense and flow and be spit out or swallowed, and it is impossible to ensure that the preparation adheres stably to the treatment site and maintain a certain spraying amount; in addition, in general, after the initial stage of a cold, the nasopharyngeal mucosa is infected by bacteria and viruses, which will cause its ability to moisten the inhaled air to deteriorate, and when the dry air is continuously inhaled, the sprayed preparation will be The moisture in the preparation will evaporate quickly with continuous breathing and become dry. After the preparation becomes dry, the effective iodine and glycyrrhizic acid substances cannot play their bactericidal and anti-inflammatory effects normally. Combining the above two reasons, the effective bactericidal time of the preparation adhering to the pharyngeal mucosa and being in a moist state is short, which will lead to a decrease in the actual bactericidal efficiency. At the same time, the anti-inflammatory effect time of glycyrrhizic acid compounds in a moist state on the treated area will also be shortened. Therefore, if the bactericidal efficiency and the action time of the anti-inflammatory ingredients contained in it are to be guaranteed, solving the problem of the preparation adhering to the treatment area and keeping it moist becomes an urgent problem to be solved. Summary of the invention

[0007] The technical problem to be solved by the present invention is: to develop a preparation for the above-mentioned original invention "a preparation with antibacterial and anti-inflammatory effects" to solve the problem that the effective moist state time of its antibacterial components and anti-inflammatory components on the treatment site is short. To solve this problem, an antibacterial and anti-inflammatory preparation with viscosity-enhancing and moisturizing effects is provided. The preparation is added with viscosity-enhancing and moisturizing components to increase the adhesion of the preparation and slow down the evaporation rate of water in the preparation with breathing, so that the antibacterial components and non-antibiotic anti-inflammatory components of the original invention of a preparation with antibacterial and anti-inflammatory effects have better adhesion to the treatment site and maintain a moist state, so as to ensure that the preparation has a high killing efficiency for bacteria and viruses and the purpose of early intervention and continuous anti-inflammatory of non-antibiotic anti-inflammatory treatment.

[0008] To solve the above problems, the technical solution adopted by the present invention is as follows: an antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects contains at least an antibacterial component, a non-antibiotic anti-inflammatory component and a viscosity-increasing and moisturizing component.

[0009] The antibacterial component in an antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects is a preparation component containing an effective iodine component. An effective iodine component refers to a preparation component that uses iodine (including elemental iodine, iodine ions, iodine complexes, organic iodine, etc.) as an antibacterial component. The principle of effective iodine sterilization is mainly that the iodine in the iodine preparation oxidizes the active groups of pathogen proteins and combines with the amino groups of the pathogens, thereby denaturing the amino acids and enzymes of the pathogens and achieving the purpose of sterilization. Common preparations in life are iodine tincture, iodine wine, and composite iodine-containing disinfectants.

[0010] Non-antibiotic anti-inflammatory ingredients refer to other preparation ingredients that do not use antibiotics to kill bacteria and viruses as anti-inflammatory treatment. The most common anti-inflammatory ingredients of this type are glucocorticoid anti-inflammatory ingredients, which can help eliminate inflammatory reactions and inhibit inflammation, thereby preventing the spread of inflammation and eliminating various symptoms caused by inflammation, thereby achieving the purpose of treating infection. Anti-inflammatory pathways are usually achieved: 1. Inhibit the migration of granulocytes and macrophages outside blood vessels and reduce inflammatory invasive tissue reactions. 2. Inhibit the recruitment of neutrophils, monocytes and macrophages to inflammatory sites. 3. Inhibit inflammatory capillary dilation, reduce the permeability of capillary walls and the formation of edema. 4. Stabilize the lysosomal membrane and reduce the release of hydrolases in the lysosomes, thereby reducing damage to tissues.

[0011] A non-antibiotic anti-inflammatory ingredient in an antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects is a glycyrrhizic acid compound. Glycyrrhizic acid compounds are a general term for glycyrrhizic acid, glycyrrhizic acid glycosides, and glycyrrhizic acid salts, including: glycyrrhizic acid, ammonium glycyrrhizinate, diammonium glycyrrhizinate, glycyrrhizic acid glycosides, potassium glycyrrhizinate, sodium glycyrrhizinate, and magnesium glycyrrhizinate. Glycyrrhizic acid compounds have an anti-inflammatory effect similar to that of glucocorticoids, among which glycyrrhizic acid is the most representative, which has a strong anti-inflammatory effect and can inhibit inflammatory reactions. The anti-inflammatory mechanism of glycyrrhizic acid is: inhibiting the metabolic levels of phospholipase A2 / arachidonic acid (PLA2 / AA), NF-κB and MAPK / AP-1 key inflammatory response signals induced by inflammatory stimulation at the initial stage, inhibiting the activity of inflammatory response signals related to the three inflammatory pathways, down-regulating the expression of pro-inflammatory cytokines related to the upstream of the inflammatory pathway, including TNF-α, IL-8, IL-1β, IIL-6, related chemokines and cyclooxygenase (COX), and blocking the downstream of the inflammatory pathway, including the generation of nitric oxide (NO), prostaglandins (PG) and reactive oxygen species (ROS). In other words, glycyrrhizic acid can play a good inhibitory role in the further development and expansion of inflammatory diseases, and glycyrrhizic acid does not have some side effects and indications of glucocorticoids, and can be used as a non-antibiotic anti-inflammatory preparation for early application to the site of infection.

[0012] A viscosity-increasing and moisturizing ingredient in an antibacterial and anti-inflammatory preparation with a viscosity-increasing and moisturizing effect refers to a substance containing a hydroxyl group added to increase the intermolecular pulling force (i.e., increase the adhesion) by utilizing the "hydrogen bond" formed by the hydroxyl group and the hydrogen in the water molecule. At the same time, the "hydrogen bond" formed by the hydroxyl group and the hydrogen in the water molecule can reduce the loss of water (i.e., the water-locking and moisturizing effect) to achieve the purpose of viscosity-increasing and moisturizing. This type of ingredient includes one or a combination of glycerol and cellulose substances.

[0013] Glycerin (‌propylene glycol) is a colorless and odorless liquid with excellent hygroscopicity. The glycerin molecule has three hydroxyl groups (-OH). The oxygen atom in the hydroxyl group carries a partial negative charge, while the water molecule is polar and its hydrogen atom carries a partial positive charge. When the hydroxyl group and the water molecule are close to each other, the negative charge of the oxygen atom and the positive charge of the hydrogen atom in the water molecule will interact to form the so-called "hydrogen bond", which makes glycerin have strong water absorption. Glycerin can even absorb moisture in the air (1 gram of glycerin can absorb about 0.4 grams of water) and lock the moisture; the high adhesion of glycerin is also based on the three hydroxyl groups in the glycerin molecule. This intermolecular interaction makes the pulling force between glycerin molecules larger, and it is not easy for a single molecule to leave, so the viscosity of glycerin is higher. When the glycerin aqueous solution is sprayed on the surface of the skin mucosa, a protective film with a certain viscosity will be formed to prevent water loss, so the use of glycerin in the present invention can increase the adhesion of the preparation and the moisturizing ability of locking moisture.

[0014] Cellulose materials include hydroxyethyl cellulose (HEC) and hydroxypropyl methyl cellulose (HPMC).

[0015] Hydroxyethyl cellulose (HEC) is a white or light yellow, odorless, non-toxic fibrous or powdered solid. There are a large number of hydroxyethyl groups (-CH2CH2OH) on its molecular chain. The hydroxyl group (-OH) in the hydroxyethyl group can form a "hydrogen bond" with the hydrogen in the water molecule. The polymer chain structure of hydroxyethyl cellulose will form a network structure in water, further capturing and fixing water molecules, thereby tightly locking water and preventing water loss; at the same time, this intermolecular interaction makes the pulling force between hydroxyethyl cellulose molecules larger, and a single molecule is not easy to leave, so the viscosity of hydroxyethyl cellulose is higher. Therefore, hydroxyethyl cellulose can be used in the present invention to increase the adhesion ability of the preparation and the moisture retention ability of locking water.

[0016] Hydroxypropyl methylcellulose (HPMC), also known as hydroxypropyl methylcellulose, is a semi-synthetic, inactive, viscoelastic polymer. Its molecular structure contains a large number of functional groups such as hydroxyl and methyl. The hydroxyl group has the same effect as the above-mentioned hydroxyethyl cellulose. The hydroxyl group (-OH) can form a "hydrogen bond" with hydrogen in water molecules to lock in moisture and increase the intermolecular pulling force, so that HPMC exhibits a certain viscosity and water-locking performance in aqueous solution. Therefore, hydroxypropyl methylcellulose can be used in the present invention to increase the adhesion ability of the preparation and the moisture-locking ability of the preparation.

[0017] In summary, when using an antibacterial and anti-inflammatory preparation with a viscosity-increasing and moisturizing effect, the viscosity-increasing and moisturizing component can increase the adhesion of the preparation and reduce the rate of water loss, thereby achieving the purpose of viscosity-increasing and moisturizing. This effectively prolongs the effective action time of the preparation adhering to the treatment site and being in a moist state, and can effectively play a bactericidal role while the glycyrrhizic acid compound plays a sustained anti-inflammatory role to prevent the expansion of inflammation and shorten the duration of inflammation. Compared with the original treatment technology, the preparation of the present invention can improve the treatment efficiency of infected wounds. DETAILED DESCRIPTION

[0019] The embodiments of the present invention include but are not limited to the following:

[0020] 1. Take 500 ml of purified water, add 3 g of glycyrrhizic acid (HPLC content 70%) into the water, heat and stir until completely dissolved, take another 300 ml of purified water, slowly add 100 g of povidone iodine powder and stir, after the temperature of the glycyrrhizic acid solution drops to room temperature, add the glycyrrhizic acid solution into the povidone iodine solution and stir evenly, then add 200 ml of glycerol and stir evenly, thus obtaining a preparation containing povidone iodine, glycyrrhizic acid and glycerol.

[0021] After testing by CMA testing and certification agency, the test items and results are as follows (suspension quantitative method): 1. Killing rate against Staphylococcus aureus ≥99% 2. Killing rate against Escherichia coli ≥99% 3. Killing rate against Candida albicans ≥99% 4. Killing logarithm of influenza virus H3N2 ≥4 5. Killing rate against Pneumococcus ≥99% 6. Killing rate against Haemophilus influenzae ≥99% 7. Multiple eye irritation test: no irritation 8. Acute oral toxicity test: practically non-toxic.

Claims

1. An antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects, characterized in that: The preparation contains at least an antibacterial component, a non-antibiotic anti-inflammatory component and a viscosity-enhancing and moisturizing component.

2. The antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects according to claim 1, characterized in that: The antibacterial component is a preparation component containing an effective iodine component.

3. The antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects according to claim 1, characterized in that: The non-antibiotic anti-inflammatory component is one or a combination of glycyrrhizic acid compounds.

4. The antibacterial and anti-inflammatory preparation with viscosity-increasing and moisturizing effects according to claim 1, characterized in that: The viscosity-increasing and moisturizing ingredients include one or a combination of glycerin and cellulose substances.