Pre-filled syringe and filling method thereof

Abstract

The invention relates to the technical field of pre-filled syringes, and particularly discloses a pre-filled syringe which comprises a needle cylinder, a needle head, a protective cap and a push rod, a piston head is arranged at one end of the push rod, the piston head is arranged in the needle cylinder in a sliding mode, and the end, away from the piston head, of the push rod extends out of the needle cylinder. The needle cylinder is connected with the needle head through the conical head, a charging opening is formed in the end, close to the conical head, of the needle cylinder, and the conical head is detachably connected with the charging opening. The inner diameter of the charging hole is not greater than that of the needle cylinder; a butt-joint cavity is formed in one end of the conical head, and the charging opening is in butt joint with the butt-joint cavity and abuts against the cavity bottom of the butt-joint cavity; a sealing ring is arranged at the cavity bottom of the butt joint cavity and abuts against the cavity bottom of the butt joint cavity and the charging opening at the same time. External threads are arranged at the end, located at the charging opening, of the needle cylinder, internal threads are arranged in the butt joint cavity, and the external threads are meshed with the internal threads; the problems that when an existing pre-filling syringe is used for loading powder, the powder is prone to flying, filling is slow and the like are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of prefilled syringes, in particular to a prefilled syringe and a filling method thereof. Background Art

[0002] Prefilled Syringe (PFS) is a new type of drug packaging system that combines drug storage and injection functions. Its core feature is that the drug is pre-filled in a sterile environment and can be used directly for injection. Prefilled syringes are gradually replacing traditional injection packaging and becoming a key technology in the biomedicine field due to their convenience, safety and environmental protection advantages.

[0003] There are many prefilled syringe products in China at present, but there is still room for optimization in product structure. For example, the existing structure is difficult to operate for prefilled powders. When the medicine is poured into the syringe from the end away from the needle and then the piston is inserted, the powder is easily caused to fly. Inhalation from the end close to the needle is very slow. The slow filling cannot meet the requirements of mass production. Summary of the invention

[0004] The object of the present invention is to provide a prefilled syringe and a filling method thereof, which solve the problems of the existing prefilled syringes that when loading powder, powder is easily caused to fly and the filling is slow.

[0005] The present invention is implemented by the following technical scheme: a prefilled syringe, comprising a syringe, a needle and a protective cap connected in sequence, a push rod with a piston head at one end, the piston head is slidably placed in the syringe, and the push rod extends out of the syringe at one end away from the piston head;

[0006] The syringe is connected to the needle head through a cone head, and a loading port is provided at one end of the syringe close to the cone head, and the cone head is detachably connected to the loading port.

[0007] Furthermore, the inner diameter of the loading port is not greater than the inner diameter of the syringe.

[0008] Furthermore, a docking cavity is provided at one end of the cone head, the charging port is docked with the docking cavity, and the charging port abuts against the cavity bottom of the docking cavity.

[0009] Furthermore, a sealing ring is provided at the bottom of the docking cavity, and the sealing ring abuts against the bottom of the docking cavity and the loading port at the same time.

[0010] Furthermore, an external thread is provided at one end of the syringe located at the loading port, and an internal thread is provided in the docking cavity, and the external thread is meshed with the internal thread.

[0011] Furthermore, the needle head is detachably connected to the cone head, and a docking joint is provided at one end of the cone head away from the syringe;

[0012] A docking sleeve is arranged at one end of the needle away from the needle tip, and the docking head is placed in the docking sleeve and is interference-fitted or thread-fitted with the docking sleeve.

[0013] Furthermore, a docking ring is coaxially arranged at one end of the cone head away from the syringe, and the protective cap is threadedly fitted or interference fit with the docking ring.

[0014] Furthermore, a limiting ring is coaxially arranged at one end of the syringe away from the loading port, the outer diameter of the limiting ring is larger than the outer diameter of the syringe, a conical cavity is arranged inside the limiting ring, and the end with a small diameter of the conical cavity is connected to the inner cavity of the syringe.

[0015] Furthermore, it also includes a mounting seat, on which two groups of buckle parts are symmetrically arranged, and the mounting seat is sleeved on the limiting ring and the syringe, and the limiting ring and the mounting seat are interference fit.

[0016] Further, a method for filling a prefilled syringe, using a prefilled syringe, comprises the following steps;

[0017] S1, installing the mounting seat on the syringe;

[0018] S2, push the end of the push rod with the piston head into the syringe from the side of the syringe close to the mounting seat, and sufficient canning space needs to be reserved between the piston head and the loading port;

[0019] S3, placing the loading port of the syringe at the top, and loading the medicine from one end of the loading port;

[0020] The piston head is pushed by the push rod to make the loaded medicine approach the loading port;

[0021] S4, connecting the cone head to the charging port;

[0022] S5, connecting the needle head to the cone head;

[0023] S6. Connect the protective cap to the cone head.

[0024] The technical solution of the present invention has at least the following advantages and beneficial effects:

[0025] 1. The inner diameter of the loading port is consistent with the inner diameter of the syringe, so compared with sucking from the front end of the traditional syringe, this method greatly improves the efficiency of filling. First, place the piston head inside the syringe, and then load the material from the loading port at the front end of the syringe. After loading, install the cone head to seal the loading port. There is basically no need to adjust the piston head, thereby avoiding drug spillage, especially powdered drugs, to avoid powdered drugs flying into the air.

[0026] 2. After the drug is filled, the piston head is pushed by the push rod to bring the loaded drug close to the loading port, thereby reducing the overall length of the needle as much as possible after the drug is filled, which is convenient for packaging and transportation; at the same time, since the loading port is large, it is not easy to spray out the powdered drug, which meets the filling rate while preventing the powder from flying. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0028] Figure 1 A schematic diagram of the structure of a prefilled syringe provided by the present invention;

[0029] Figure 2 for Figure 1 A magnified schematic diagram of the structure at center A;

[0030] Figure 3 A schematic diagram of the structure of a cone head in a prefilled syringe provided by the present invention;

[0031] Figure 4 A schematic diagram of the explosion structure of a cone head and a needle in a prefilled syringe provided by the present invention;

[0032] Figure 5 A schematic diagram of the explosion structure of a syringe and a mounting seat in a prefilled syringe provided by the present invention;

[0033] Icons: 1. Syringe, 11. Loading port, 12. External thread, 13. Limiting ring, 131. Conical cavity, 2. Needle, 21. Docking sleeve, 3. Protective cap, 4. Piston head, 5. Push rod, 6. Conical head, 61. Docking cavity, 62. Sealing ring, 63. Internal thread, 64. Docking joint, 65. Docking ring, 7. Mounting seat, 71. Hand piece. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0035] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Reference Figures 1 to 5 As shown, this embodiment provides a prefilled syringe, including a syringe 1, a needle 2 and a protective cap 3 connected in sequence, a push rod 5 with a piston head 4 at one end, and the push rod 5 is threadedly matched or press-fitted with the piston head 4; the piston head 4 is slidably placed in the syringe 1, and the end of the push rod 5 away from the piston head 4 extends out of the syringe 1, and the end of the push rod 5 away from the piston head 4 is provided with a handle, which is a straight design or an arc-edge design, which can meet the usage habits of different groups of people.

[0037] More specifically, Figure 1-Figure 4 As shown, the syringe 1 is connected to the needle 2 through the cone head 6, and a loading port 11 is provided at one end of the syringe 1 near the cone head 6. The cone head 6 and the loading port 11 are detachably connected. In specific implementation, the inner diameter of the loading port 11 is not larger than the inner diameter of the syringe 1. Usually, the inner diameter of the loading port 11 is consistent with the inner diameter of the syringe 1. Therefore, compared with inhaling from the front end of the traditional syringe 1, this method greatly improves the filling efficiency. First, the piston head 4 is placed inside the syringe 1, and then the material is loaded from the loading port 11 at the front end of the syringe 1. After the loading is completed, the cone head 6 is installed to seal the loading port 11. There is basically no need to adjust the piston head 4, thereby avoiding drug overflow, especially powdered drugs, to avoid powdered drugs flying into the air.

[0038] A docking cavity 61 is provided at one end of the cone head 6, and the loading port 11 is docked with the docking cavity 61, which can be an interference fit, so that the loading port 11 abuts against the bottom of the docking cavity 61; more specifically, a sealing ring 62 is provided at the bottom of the docking cavity 61, and the sealing ring 62 abuts against the bottom of the docking cavity 61 and the loading port 11 at the same time, and then the gap between the loading port 11 and the docking cavity 61 can be further sealed by the sealing ring 62, thereby ensuring the air tightness between the syringe 1 and the cone head 6.

[0039] More specifically, Figure 1-Figure 3As shown, as another connection method, the syringe 1 is provided with an external thread 12 at one end of the loading port 11, and an internal thread 63 is provided in the docking cavity 61. The external thread 12 is meshed with the internal thread 63, and then the cone head 6 is rotated to match the external thread 12 with the internal thread 63, so that the cone head 6 and the syringe 1 can be stably connected. Based on the loading of the loading port 11, the loading port 11 can be quickly sealed, thereby improving the overall connection strength and the efficiency of assembly and production.

[0040] More specifically, Figure 1-Figure 4 As shown, the needle 2 and the cone head 6 are detachably connected, and a docking joint 64 is provided at the end of the cone head 6 away from the syringe 1; in specific implementation, a docking sleeve 21 is provided at the end of the needle 2 away from the needle tip, and the docking joint 64 is placed in the docking sleeve 21 and has an interference fit or a threaded fit with the docking sleeve 21. The interference fit is consistent with the traditional connection method of the needle 2 and the Luer connector, and can be plugged in, so that the cone head 6 can be replaced with different needles 2.

[0041] The end of the syringe 1 close to the cone head and the cone head 6 may be provided with reinforcing ribs or polygons that are conducive to rotation, so as to facilitate the screwing or plugging of the cone head 6 and the loading port 11 on the syringe 1.

[0042] More specifically, the cone head 6 can be an independent accessory of the 6:100 threaded Luer cone head 6, that is, the cone head 6 and the needle head 2 are two separate accessories, the needle head 2 and the cone head 6 are threadedly matched, and the two are connected to each other after rotation.

[0043] The cone head 6 can also adopt a 6:100 screw-mouth Luer cone head 6 with a needle as an independent accessory, that is, the needle head 2 and the cone head 6 are a whole, and the needle head 2 is not separated from the cone head 6.

[0044] The cone head 6 can also adopt an independent accessory of the 6:100 straight-mouth Luer cone head 6, that is, the cone head 6 and the needle 2 are two separate accessories, the needle 2 and the cone head 6 fit together, and the two are connected to each other after being plugged in.

[0045] like Figure 1 and Figure 2 As shown, a docking ring 65 is coaxially provided at one end of the cone head 6 away from the syringe 1, and the protective cap 3 is threadedly fitted or interference fit with the docking ring 65, so that the protective cap 3 can be firmly connected to the cone head 6 while preventing the protective cap 3 from being detached in unexpected circumstances such as falling.

[0046] Based on the above-mentioned connection and cooperation mode between the cone head 6 and the needle head 2, the protective cap 3 can be connected to the cone head 6, and the two can be threadedly matched or interference-fitted with each other.

[0047] As another embodiment, based on the above-mentioned connection and cooperation mode between the cone head 6 and the needle head 2, the protective cap 3 can also be directly connected to the needle head 2, and the two are interference fit or thread fit.

[0048] For the selection of the protective cap 3, plastic or rubber material can be selected. The protective cap 3 can also be composed of materials such as silicone inside and a PP transparent sheath structure outside. The silicone is used to seal the gap between the needle 2 and the PP transparent part, and the material of the PP transparent part sheath is harder to protect the silicone and the needle 2.

[0049] like Figure 1 and Figure 5 As shown, a limit ring 13 is coaxially arranged at one end of the syringe 1 away from the loading port 11. The outer diameter of the limit ring 13 is larger than the outer diameter of the syringe 1. A conical cavity 131 is arranged in the limit ring 13. The end with a small diameter of the conical cavity 131 is connected with the inner cavity of the syringe 1. When the piston head 4 is pushed into the syringe 1, the piston head 4 can quickly enter the conical cavity 131 and then quickly enter the syringe 1 through the guidance of the end with a large diameter of the conical cavity 131, thereby improving the overall assembly speed.

[0050] More specifically, Figure 1 and Figure 5 As shown, it also includes a mounting seat 7, on which two groups of hand latches 71 are symmetrically arranged. The hand latches 71 are usually flanges or finger rests. The mounting seat 7 is sleeved on the limiting ring 13 and the syringe 1. The limiting ring 13 and the mounting seat 7 are interference fit, so that the mounting seat 7 and the syringe 1 are detachably connected, and different types of hand latches 71 are selected according to different finished syringes.

[0051] like Figure 1-Figure 5 As shown, a method for filling a prefilled syringe, using a prefilled syringe, is characterized in that it includes the following steps:

[0052] S1, install the mounting seat 7 on the syringe 1; put the mounting seat 7 on the syringe 1 from one end of the loading port 11, and then move it to the other end until the mounting seat 7 and the limiting ring 13 are interference fit.

[0053] S2. Push the end of the push rod 5 with the piston head 4 into the syringe 1 from the side of the syringe 1 close to the mounting seat 7. Sufficient canning space needs to be reserved between the piston head 4 and the loading port 11.

[0054] S3. Place the loading port 11 of the syringe 1 at the top, and load the medicine from one end of the loading port 11 through the injection device; the syringe 1 can be set on an assembly line, and then the medicine can be quickly loaded with the help of a machine.

[0055] During manual filling, after the medicine is filled, the piston head 4 is pushed by the push rod 5 to bring the loaded medicine close to the loading port 11, thereby reducing the overall length of the needle as much as possible after the medicine is filled, which is convenient for packaging box transportation; at the same time, since the loading port 11 is large, it is not easy to spray out the powdered medicine, which meets the filling rate while preventing the powder from flying.

[0056] S4, then connect the cone head 6 to the charging port 11, and block the charging port 11. S5, connect the needle head 2 to the cone head 6; S6, connect the protective cap 3 to the cone head 6, and complete the assembly and filling of the entire syringe.

[0057] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A prefilled syringe, comprising a syringe (1), a needle (2) and a protective cap (3) connected in sequence, a push rod (5) with a piston head (4) at one end, the piston head (4) being slidably disposed in the syringe (1), and an end of the push rod (5) away from the piston head (4) extending out of the syringe (1); Features: The syringe (1) is connected to the needle (2) via a cone head (6); a loading port (11) is provided at one end of the syringe (1) close to the cone head (6); and the cone head (6) and the loading port (11) are detachably connected.

2. A prefilled syringe according to claim 1, characterized in that: The inner diameter of the loading port (11) is no greater than the inner diameter of the syringe (1).

3. A prefilled syringe according to claim 2, characterized in that: A docking cavity (61) is provided at one end of the cone head (6), the charging port (11) is docked with the docking cavity (61), and the charging port (11) abuts against the cavity bottom of the docking cavity (61).

4. A prefilled syringe according to claim 3, characterized in that: A sealing ring (62) is provided at the bottom of the docking cavity (61), and the sealing ring (62) abuts against the bottom of the docking cavity (61) and the charging port (11) at the same time.

5. A prefilled syringe according to claim 4, characterized in that: An external thread (12) is provided at one end of the syringe (1) located at the loading port (11), and an internal thread (63) is provided in the docking cavity (61), and the external thread (12) is meshed with the internal thread (63).

6. A prefilled syringe according to claim 5, characterized in that: The needle head (2) is detachably connected to the cone head (6), and a docking joint (64) is provided at one end of the cone head (6) away from the syringe (1); A docking sleeve (21) is provided at one end of the needle (2) away from the needle tip, and the docking head (64) is placed in the docking sleeve (21) and is interference-fitted or thread-fitted with the docking sleeve (21).

7. A prefilled syringe according to claim 5, characterized in that: A docking ring (65) is coaxially arranged at one end of the cone head (6) away from the syringe (1), and the protective cap (3) is threadedly fitted or interference-fitted with the docking ring (65).

8. A prefilled syringe according to any one of claims 1 to 7, characterized in that: A limiting ring (13) is coaxially arranged at one end of the syringe (1) away from the loading port (11); the outer diameter of the limiting ring (13) is larger than the outer diameter of the syringe (1); a conical cavity (131) is arranged inside the limiting ring (13); the end with a smaller diameter of the conical cavity (131) is connected to the inner cavity of the syringe (1).

9. A prefilled syringe according to claim 8, characterized in that: It also comprises a mounting seat (7), on which two groups of buckle parts (71) are symmetrically arranged, and the mounting seat (7) is sleeved on the limiting ring (13) and the syringe (1), and the limiting ring (13) and the mounting seat (7) are interference fit.

10. A method for filling a prefilled syringe, using the prefilled syringe according to claim 9, characterized in that: The steps include: S1, installing the mounting seat (7) on the syringe (1); S2. Push the end of the push rod (5) with the piston head (4) into the syringe (1) from the side of the syringe (1) close to the mounting seat (7), and sufficient canning space needs to be reserved between the piston head (4) and the loading port (11); S3, placing the loading port (11) of the syringe (1) upward, and loading the medicine from one end of the loading port (11); The piston head (4) is pushed by the push rod (5) so that the loaded medicine approaches the loading port (11); S4, connecting the cone head (6) to the charging port (11); S5, connecting the needle (2) and the cone (6); S6. Connect the protective cap (3) to the cone head (6).

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