Traditional Chinese medicine skin care cream for repairing skin and preparation method thereof

Abstract

The present invention relates to the technical field of skin care product preparation, and specifically to a traditional Chinese medicine skin care cream for skin repair and a preparation method thereof. The preparation method comprises the following steps: preparing an acylated alkyl glucoside; preparing a safflower extract; preparing a suspension of naringin and the safflower extract; and preparing a traditional Chinese medicine skin care cream for skin repair. The present invention utilizes myristic acid and an alkyl glucoside to prepare the acylated alkyl glucoside. The myristic acid is then acylated on the alkyl glucoside using the lipase Lipozyme 435, thereby preventing damage to the flavonoid structure during microwave extraction. Furthermore, after acylation, the alkyl glucoside significantly enhances its lipophilicity. This enhanced lipophilicity enables the alkyl glucoside to more effectively interact with fat-soluble flavonoids, thereby improving its solubility and dispersibility in the lipid phase. This reduces oxidative loss of flavonoids during the safflower leaf extraction process and increases the flavonoid content in the safflower leaf extract.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care product preparation, in particular to a traditional Chinese medicine skin care cream for repairing skin and a preparation method thereof. Background Art

[0002] The leaves of the genus Amaranth are used as medicine. Turpinia arguta The dried leaves of Seem. are often used in traditional Chinese medicine to clear away heat and detoxify, promote blood circulation and reduce swelling. They can be used externally to treat skin inflammation, sores, etc. Because its extract is rich in flavonoids, phenolic acids and polysaccharides, adding Seem. extract to skin care products can make the skin care products have antioxidant and skin repair effects.

[0003] The extract of the Chinese yam is generally prepared by microwave extraction or ultrasonic extraction of the Chinese yam leaves. Microwave extraction uses microwave radiation to make molecules vibrate at high speed, generating heat to promote the release of solutes. Ultrasonic extraction uses ultrasonic cavitation effect to destroy cell walls and accelerate solvent penetration. Compared with ultrasonic extraction, microwave extraction is faster and the extraction temperature is lower during ultrasonic extraction. The flavonoids in the Chinese yam leaves are easily oxidized under long-term exposure. Therefore, in order to increase the content of flavonoids in the Chinese yam extract, microwave extraction is generally used on the Chinese yam leaves.

[0004] The use of surfactants in conjunction with microwave extraction can improve the extraction efficiency of the leaves of the Schizonepeta tenuifolia. The conventional surfactant sodium lauryl sulfate is often used to assist ultrasonic extraction. However, sodium lauryl sulfate is irritating to the skin, so it is necessary to remove sodium lauryl sulfate as an auxiliary extraction agent after microwave extraction. However, sodium lauryl sulfate is easily soluble in water and can solubilize flavonoids. Therefore, if strict removal operations and testing are not performed, sodium lauryl sulfate is very likely to remain in the Schizonepeta tenuifolia extract. Therefore, a surfactant that can replace sodium lauryl sulfate is needed. While improving the extraction effect of flavonoids in the Schizonepeta tenuifolia, the irritation to the skin is weaker than sodium lauryl sulfate, thereby reducing the subsequent complexity of removing the surfactant and the production cost.

[0005] Therefore, the present invention provides a traditional Chinese medicine skin care cream for repairing skin and a preparation method thereof, in order to solve the deficiencies of the above-mentioned prior art. Summary of the Invention

[0006] In view of the deficiencies in the prior art, the present invention aims to provide a traditional Chinese medicine skin care cream for repairing skin and a preparation method thereof.

[0007] A method for preparing a traditional Chinese medicine skin care cream for repairing skin comprises the following steps:

[0008] S1: Preparation of acylated alkyl glucoside

[0009] After mixing alkyl glucoside and myristic acid, adding 4A molecular sieve and lipase, removing lipase and molecular sieve after reaction, to obtain acylated alkyl glucoside;

[0010] S2: Preparation of the Psoralea corylifolia extract

[0011] The acylated alkyl glucoside is mixed with water to obtain an acylated alkyl glucoside solution, the leaves of the Herba Cynanchifolia are weighed and crushed, and the mixture is mixed with water to obtain a Herba Cynanchifolia extract, the acylated alkyl glucoside solution and the Herba Cynanchifolia extract are mixed, and microwave extraction is performed to obtain a Herba Cynanchifolia extract;

[0012] S3: Preparation of naringin and scutellaria baicalensis extract suspension

[0013] Oleic acid is dissolved in a NaOH solution to obtain an oleic acid solution, acylated alkyl glucoside is dissolved in ethanol, and the oleic acid solution is added to prepare composite vesicles, naringin and a Psoralea corylifolia extract are mixed to prepare a composite core material, and the composite core material is injected into the composite vesicles using an ethanol injection method to obtain a suspension of naringin and the Psoralea corylifolia extract;

[0014] S4: Preparation of traditional Chinese medicine skin care cream for skin repair

[0015] Carbomer, glycerin, sclerotium gum, naringin, a suspension of the scutellaria baicalensis extract and deionized water are mixed and stirred evenly, and triethanolamine is added dropwise and subjected to swelling treatment to obtain a traditional Chinese medicine skin care cream for repairing skin.

[0016] Furthermore, step S1 prepares acylated alkyl glucoside, comprising the following steps:

[0017] S1.1: Mix 1-2 parts by weight of alkyl glycoside and 10-20 parts by weight of myristic acid, stir magnetically at 300-350 rpm for 12-13 hours, and heat to 50-55°C. Then, add 100 mg / mL of 4A molecular sieves and 20-25 mg / mL of lipase, and react for 24-26 hours.

[0018] S1.2: After the reaction is completed, the product is centrifuged at 11,000-12,000 rpm at 4°C for 7-10 minutes. Finally, the product is filtered through a membrane to remove the lipase and molecular sieves to obtain the acylated alkyl glucoside.

[0019] Furthermore, step S2 of preparing the Psoralea corylifolia extract comprises the following steps:

[0020] S2.1: Mix the acylated alkyl glucoside with water at a solid-liquid ratio of 1 g:(20-30) mL to obtain an acylated alkyl glucoside solution;

[0021] S2.2: Weigh the dried leaves of Scutellaria baicalensis, crush them into 60 mesh, mix the crushed Scutellaria baicalensis leaves with water at a material-liquid ratio of 1 g: (10-20) mL to obtain the Scutellaria baicalensis extract, mix the acylated alkyl glucoside solution and the Scutellaria baicalensis extract at a mass ratio of 1: (1-5), put them into a microwave extractor preheated to 60-70°C, and perform microwave extraction for 5-20 minutes to obtain the Scutellaria baicalensis extract.

[0022] Furthermore, step S3 prepares a suspension of naringin and the Herba Cynanchifoliae extract, comprising the following steps:

[0023] S3.1: Dissolve 1-2 parts by mass of oleic acid in 4-8 parts by mass of 0.1-0.2 mol / L NaOH solution and stir at 400 rpm for 15-20 minutes to obtain an oleic acid solution;

[0024] S3.2: Dissolve 1-2 parts by mass of acylated alkyl glucoside in ethanol and stir for 5-10 minutes until completely dissolved. Then, add an equal volume of oleic acid solution and adjust the pH of the system to 6-6.5. Magnetic stirring is continued at 400-450 rpm for 1-1.5 hours to obtain composite vesicles.

[0025] S3.3: mixing naringin and the extract of the Chinese yew tree in a mass ratio of (2-2.5):1, and then adding anhydrous ethanol in a mass fraction of 5-15 wt % to obtain a composite core material;

[0026] S3.4: Inject the composite core material into the composite vesicles using an ethanol injection method, and then remove the ethanol by magnetic stirring at a speed of 400-450 r / min and an environment of 75-80° C. for 1-1.5 hours to obtain a suspension of naringin and the scutellaria baicalensis extract.

[0027] Furthermore, step S4 prepares a traditional Chinese medicine skin care cream for repairing skin, comprising the following steps:

[0028] S4.1: Mix 1-3 wt% carbomer, 5-8 wt% glycerol, 4-8 wt% sclerotium gum, and 40-50 wt% naringin with the suspension of the Scutellaria baicalensis extract and deionized water, stirring uniformly at 100-150 rpm for 30-35 min.

[0029] S4.2: Add an appropriate amount of triethanolamine to adjust the pH to 6-7, let it stand for 12-14 hours to allow it to swell, then add 50% of the system mass of deionized water, stir for 30-35 minutes, and obtain a traditional Chinese medicine skin care cream for repairing skin.

[0030] Furthermore, the specific preparation steps of alkyl glycoside are:

[0031] Preheat 15-25 parts by mass of n-octanol and 0.5-1 parts by mass of an acid catalyst in a reaction flask to 40-50°C for 30-35 minutes, then add 10-20 parts by mass of glucosamine hydrochloride, reduce the internal pressure of the reaction flask to 0.05-0.08 MPa, stir magnetically for 5-10 minutes, heat in an oil bath to 75-80°C, and react for 2-3 hours. After the reaction is completed, filter the reaction product under reduced pressure, then rinse with water, dissolve and collect, and concentrate by reduced pressure distillation on a rotary evaporator. Place in an oven at 105-110°C to quickly dry the water to obtain a crude product.

[0032] The crude product was extracted, allowed to stand and decomposed, and the resulting aqueous phase was separated and collected using a separatory funnel. The aqueous solution obtained by extraction was then neutralized with a 10 wt % sodium hydroxide solution to a pH of 7-7.5, concentrated by reduced pressure distillation using a rotary evaporator, and then transferred to a vacuum oven for drying at 50-55° C. to obtain an alkyl glycoside.

[0033] Furthermore, the lipase is specifically Lipozyme 435 enzyme.

[0034] Furthermore, the filtration diameter of the filter membrane is 0.22 μm.

[0035] A traditional Chinese medicine skin care cream for repairing skin is prepared by the above-mentioned method for preparing the traditional Chinese medicine skin care cream for repairing skin.

[0036] Compared with the prior art, the present invention has at least the following beneficial effects:

[0037] 1. The present invention utilizes myristic acid and alkyl glycoside to prepare acylated alkyl glycoside, and uses lipase Lipozyme 435 to acylate the alkyl glycoside with myristic acid. Myristic acid has a moderate carbon chain length and can provide better balance after combining with the alkyl glycoside, thereby maintaining stability under weak acid to weak alkaline conditions and avoiding damage to the flavonoid structure during microwave extraction. In addition, after the alkyl glycoside is acylated, the lipophilicity is significantly enhanced. This enhanced lipophilicity enables the alkyl glycoside to more effectively interact with fat-soluble flavonoid compounds, thereby improving its solubility and dispersibility in the lipid phase, thereby reducing the oxidative loss of flavonoids during the extraction of the leaves of the safflower oil plant and increasing the content of flavonoids in the safflower oil plant extract.

[0038] 2. The present invention combines the prepared acylated alkyl glucoside with oleic acid to prepare vesicles for encapsulating naringin and the Herba Cynanchifoliae extract, and then prepares a suspension of naringin and the Herba Cynanchifoliae extract. The flavonoids in the naringin and Herba Cynanchifoliae extract are poorly water-soluble, while the molecular groups of the acylated alkyl glucoside and oleic acid can be chemically bonded to prepare vesicles having a double-layer structure of a hydrophilic shell and a hydrophobic core. The flavonoids in the naringin and Herba Cynanchifoliae extract can be encapsulated in the double-layer vesicles, thereby improving the encapsulation efficiency of the dispersed vesicles in the suspension for the core material. In addition, the groups of the acylated alkyl glucoside can attract the naringin and Herba Cynanchifoliae extract in the core material, thereby preventing the core material from escaping and further improving the encapsulation efficiency.

[0039] 3. The present invention uses acylated alkyl glucoside for extracting the Schizonepeta tenuifolia extract and preparing vesicles. Acylated alkyl glucoside has high surface activity and low surface tension, and at the same time, as a polar solvent, can be combined with microwave extraction to extract the Schizonepeta tenuifolia leaves, thereby increasing the content of flavonoids in the Schizonepeta tenuifolia extract. Moreover, the acylated alkyl glucoside used as an auxiliary extractant is a bio-based derivative material. Compared with high-molecular chemical synthetic products, the acylated alkyl glucoside has low skin irritation, good biodegradability, and is mild and safe. Moreover, the acylated alkyl glucoside can not only be used as an auxiliary extractant, but also be used to prepare vesicles for coating, and has multiple functions, thereby reducing the preparation cost.

[0040] 4. The present invention combines naringin with the extract of Glechoma longituba. Both naringin and the extract of Glechoma longituba contain a variety of natural active ingredients. For example, naringin has antioxidant and antibacterial effects. The extract of Glechoma longituba has the effect of repairing the skin. When naringin is used in combination with the extract of Glechoma longituba, the damaged skin is first repaired by the extract of Glechoma longituba, and then the antioxidant and antibacterial effects of naringin are exerted, thereby improving the effect of skin repair. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the present disclosure and, together with the description, further serve to explain the principles of the present disclosure and to enable one skilled in the relevant art to make and use the present disclosure.

[0042] Figure 1 This is a flow chart of a method for preparing a traditional Chinese medicine skin cream for repairing skin adopted in an embodiment of the present invention. DETAILED DESCRIPTION

[0043] The following describes in detail a traditional Chinese medicine skin care cream for skin repair and its preparation method provided by the present invention, in conjunction with the accompanying drawings and specific embodiments. It is also noted that, in order to provide a more detailed description, the following embodiments are best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement certain known technologies. Furthermore, the accompanying drawings are only for the purpose of describing the embodiments in more detail and are not intended to limit the present invention in any specific manner.

[0044] Example 1:

[0045] A method for preparing a traditional Chinese medicine skin care cream for repairing skin, such as Figure 1 As shown, the following steps are included:

[0046] S1: Preparation of acylated alkyl glucoside

[0047] S1.1: Preheat 15 parts by mass of n-octanol and 0.5 parts by mass of an acid catalyst in a reaction flask to 40°C for 30 minutes, then add 10 parts by mass of glucosamine hydrochloride. Reduce the internal pressure of the reaction flask to 0.05 MPa, stir magnetically for 5 minutes, heat in an oil bath to 75°C, and react for 2 hours. After the reaction, filter the resulting product under reduced pressure, then rinse with water, dissolve, collect, and concentrate under reduced pressure using a rotary evaporator. Place in an oven at 105°C to quickly dry the product to obtain a crude product.

[0048] The crude product was extracted, and after standing for separation, the aqueous phase was separated and collected using a separatory funnel. The aqueous solution obtained by extraction was then neutralized with a 10 wt % sodium hydroxide solution to a pH of 7, concentrated by reduced pressure distillation using a rotary evaporator, and then transferred to a vacuum oven and dried at 50° C. to obtain an alkyl glycoside.

[0049] 1 part by mass of alkyl glycoside and 10 parts by mass of myristic acid were mixed and magnetically stirred at 300 r / min for 12 h while heating to 50°C. Subsequently, 100 mg / mL of 4A molecular sieves and 20 mg / mL of Lipozyme 435 enzyme were added and reacted for 24 h.

[0050] S1.2: After the reaction is completed, the product is centrifuged at 11,000 rpm for 7 minutes at 4°C. Finally, the product is filtered through a 0.22 μm filter membrane to remove the lipase and molecular sieves to obtain the acylated alkyl glucoside.

[0051] S2: Preparation of the Psoralea corylifolia extract

[0052] S2.1: Mix the acylated alkyl glucoside with water at a material-liquid ratio of 1 g:20 mL to obtain an acylated alkyl glucoside solution;

[0053] S2.2: Weigh the dried leaves of Scutellaria baicalensis, crush them into 60 mesh, mix the crushed Scutellaria baicalensis leaves with water at a material-liquid ratio of 1 g:10 mL to obtain the Scutellaria baicalensis extract, mix the acylated alkyl glucoside solution and the Scutellaria baicalensis extract at a mass ratio of 1:1, put them into a microwave extractor preheated to 60°C, and extract them for 5 minutes to obtain the Scutellaria baicalensis extract.

[0054] S3: Preparation of naringin and scutellaria baicalensis extract suspension

[0055] S3.1: Dissolve 1 part by mass of oleic acid in 4 parts by mass of 0.1 mol / L NaOH solution and stir at 400 rpm for 15 min to obtain an oleic acid solution;

[0056] S3.2: Dissolve 1 part by mass of acylated alkyl glucoside in ethanol and stir for 5 minutes until completely dissolved. Then, add an equal volume of oleic acid solution, adjust the pH of the system to 6, and magnetically stir at 400 rpm for 1 hour to obtain composite vesicles.

[0057] S3.3: mixing naringin and the extract of the Chinese yew tree in a mass ratio of 2:1, and then adding anhydrous ethanol at a mass fraction of 5 wt % to obtain a composite core material;

[0058] S3.4: The composite core material was injected into the composite vesicles by the ethanol injection method, and then the ethanol was removed by magnetic stirring at a speed of 400 r / min and an environment of 75°C for 1 hour to obtain a suspension of naringin and the scutellaria baicalensis extract.

[0059] S4: Preparation of traditional Chinese medicine skin care cream for skin repair

[0060] S4.1: Mix 1 wt% carbomer, 5 wt% glycerol, 4 wt% sclerotium gum, and 40 wt% naringin with the suspension of the Herba Cynanchifoliae extract and deionized water, stirring uniformly at 100 rpm for 30 min.

[0061] S4.2: Add an appropriate amount of triethanolamine to adjust the pH to 6, let it stand for 12 hours to allow it to swell, then add 50% of the system mass of deionized water, stir for 30 minutes, and obtain a traditional Chinese medicine skin care cream for repairing skin.

[0062] Example 2:

[0063] A method for preparing a traditional Chinese medicine skin care cream for repairing skin, such as Figure 1 As shown, the following steps are included:

[0064] S1: Preparation of acylated alkyl glucoside

[0065] S1.1: Preheat 25 parts by mass of n-octanol and 1 part by mass of an acid catalyst in a reaction flask to 40°C for 30 minutes, then add 20 parts by mass of glucosamine hydrochloride. Reduce the internal pressure of the reaction flask to 0.05 MPa, stir magnetically for 5 minutes, heat in an oil bath to 75°C, and react for 2 hours. After the reaction, filter the resulting product under reduced pressure, rinse with water, dissolve, collect, and concentrate by vacuum distillation on a rotary evaporator. Place in an oven at 105°C to quickly dry the product to obtain a crude product.

[0066] The crude product was extracted, and after standing for separation, the aqueous phase was separated and collected using a separatory funnel. The aqueous solution obtained by extraction was then neutralized with a 10 wt % sodium hydroxide solution to a pH of 7, concentrated by reduced pressure distillation using a rotary evaporator, and then transferred to a vacuum oven and dried at 50° C. to obtain an alkyl glycoside.

[0067] 2 parts by mass of alkyl glycoside and 20 parts by mass of myristic acid were mixed and magnetically stirred at a speed of 300 r / min for 12 h while heating to 50°C. Subsequently, 100 mg / mL of 4A molecular sieves and 20 mg / mL of Lipozyme 435 enzyme were added and reacted for 24 h.

[0068] S1.2: After the reaction is completed, the product is centrifuged at 11,000 rpm for 7 minutes at 4°C. Finally, the product is filtered through a 0.22 μm filter membrane to remove the lipase and molecular sieves to obtain the acylated alkyl glucoside.

[0069] S2: Preparation of the Psoralea corylifolia extract

[0070] S2.1: Mixing the acylated alkyl glucoside with water at a material-liquid ratio of 1 g:30 mL to obtain an acylated alkyl glucoside solution;

[0071] S2.2: Weigh the dried leaves of Scutellaria baicalensis, crush them into 60 mesh, mix the crushed Scutellaria baicalensis leaves with water at a material-liquid ratio of 1g:20mL to obtain the Scutellaria baicalensis extract, mix the acylated alkyl glucoside solution and the Scutellaria baicalensis extract at a mass ratio of 1:5, put them into a microwave extractor preheated to 60°C, and extract them for 5 minutes to obtain the Scutellaria baicalensis extract.

[0072] S3: Preparation of naringin and scutellaria baicalensis extract suspension

[0073] S3.1: Dissolve 2 parts by mass of oleic acid in 8 parts by mass of 0.1 mol / L NaOH solution and stir at 400 rpm for 15 min to obtain an oleic acid solution;

[0074] S3.2: Dissolve 2 parts by mass of acylated alkyl glucoside in ethanol and stir for 5 minutes until completely dissolved. Then, add an equal volume of oleic acid solution, adjust the pH of the system to 6, and magnetically stir at 400 rpm for 1 hour to obtain composite vesicles.

[0075] S3.3: mixing naringin and the extract of the Chinese yew tree in a mass ratio of 2.5:1, and then adding anhydrous ethanol at a mass fraction of 5 wt % to obtain a composite core material;

[0076] S3.4: The composite core material was injected into the composite vesicles by the ethanol injection method, and then the ethanol was removed by magnetic stirring at a speed of 400 r / min and an environment of 75°C for 1 hour to obtain a suspension of naringin and the scutellaria baicalensis extract.

[0077] S4: Preparation of traditional Chinese medicine skin care cream for skin repair

[0078] S4.1: Mix 3 wt% carbomer, 8 wt% glycerol, 8 wt% sclerotium gum, 50 wt% naringin, the suspension of the Herba Cynanchifoliae extract, and deionized water, stirring uniformly at 100 rpm for 30 min.

[0079] S4.2: Add an appropriate amount of triethanolamine to adjust the pH to 6, let it stand for 12 hours to allow it to swell, then add 50% of the system mass of deionized water, stir for 30 minutes, and obtain a traditional Chinese medicine skin care cream for repairing skin.

[0080] Example 3:

[0081] A method for preparing a traditional Chinese medicine skin care cream for repairing skin, such as Figure 1 As shown, the following steps are included:

[0082] S1: Preparation of acylated alkyl glucoside

[0083] S1.1: Preheat 15 parts by mass of n-octanol and 0.5 parts by mass of an acid catalyst in a reaction flask to 50°C for 35 minutes, then add 10 parts by mass of glucosamine hydrochloride. Reduce the internal pressure of the reaction flask to 0.05 MPa, stir magnetically for 10 minutes, heat in an oil bath to 80°C, and react for 3 hours. After the reaction, filter the resulting product under reduced pressure, then rinse with water, dissolve, collect, and concentrate under reduced pressure using a rotary evaporator. Place in an oven at 110°C to quickly dry the product to obtain a crude product.

[0084] The crude product was extracted, and after standing for separation, the aqueous phase was separated and collected using a separatory funnel. The aqueous solution obtained by extraction was then neutralized with a 10 wt % sodium hydroxide solution to a pH of 7.5, concentrated by reduced pressure distillation using a rotary evaporator, and then transferred to a vacuum oven and dried at 55° C. to obtain an alkyl glycoside.

[0085] 1 part by mass of alkyl glycoside and 10 parts by mass of myristic acid were mixed and magnetically stirred at 350 r / min for 13 h while heating to 55°C. Subsequently, 100 mg / mL of 4A molecular sieves and 20 mg / mL of Lipozyme 435 enzyme were added and reacted for 26 h.

[0086] S1.2: After the reaction is completed, the product is centrifuged at 12,000 rpm for 10 min at 4°C. Finally, the product is filtered through a 0.22 μm filter membrane to remove the lipase and molecular sieves to obtain the acylated alkyl glucoside.

[0087] S2: Preparation of the Psoralea corylifolia extract

[0088] S2.1: Mix the acylated alkyl glucoside with water at a material-liquid ratio of 1 g:20 mL to obtain an acylated alkyl glucoside solution;

[0089] S2.2: Weigh the dried leaves of Scutellaria baicalensis, crush them into 60 mesh, mix the crushed Scutellaria baicalensis leaves with water at a material-liquid ratio of 1g:10mL to obtain the Scutellaria baicalensis extract, mix the acylated alkyl glucoside solution and the Scutellaria baicalensis extract at a mass ratio of 1:1, put them into a microwave extractor preheated to 70°C, and extract them for 5 minutes to obtain the Scutellaria baicalensis extract.

[0090] S3: Preparation of naringin and scutellaria baicalensis extract suspension

[0091] S3.1: Dissolve 1 part by mass of oleic acid in 4 parts by mass of 0.2 mol / L NaOH solution and stir at 400 rpm for 20 min to obtain an oleic acid solution;

[0092] S3.2: Dissolve 1 part by mass of acylated alkyl glucoside in ethanol and stir for 10 min until completely dissolved. Then, add an equal volume of oleic acid solution, adjust the pH of the system to 6, and magnetically stir at 450 rpm for 1.5 h to obtain composite vesicles.

[0093] S3.3: mixing naringin and the extract of the Chinese yew tree in a mass ratio of 2:1, and then adding anhydrous ethanol at a mass fraction of 5 wt % to obtain a composite core material;

[0094] S3.4: The composite core material was injected into the composite vesicles by the ethanol injection method, and then the ethanol was removed by magnetic stirring at a speed of 400 r / min and an environment of 80°C for 1.5 h to obtain a suspension of naringin and the scutellaria baicalensis extract.

[0095] S4: Preparation of traditional Chinese medicine skin care cream for skin repair

[0096] S4.1: Mix 1 wt% carbomer, 5 wt% glycerol, 4 wt% sclerotium gum, and 40 wt% naringin with the suspension of the Scutellaria baicalensis extract and deionized water, stirring uniformly at 150 rpm for 30 min.

[0097] S4.2: Add an appropriate amount of triethanolamine to adjust the pH to 7, let it stand for 14 hours to allow it to swell, then add 50% of the system mass of deionized water, stir for 35 minutes, and obtain a traditional Chinese medicine skin care cream for repairing skin.

[0098] Comparative Example 1:

[0099] Compared with Example 1, the difference of Comparative Example 1 is that myristic acid is not added to react with the alkyl glucoside in step S1, and in step S2, the acylated alkyl glucoside is replaced by the alkyl glucoside prepared in step S1.1, specifically:

[0100] S1: Preparation of alkyl glycosides

[0101] S1.1: Preheat 15 parts by mass of n-octanol and 0.5 parts by mass of an acid catalyst in a reaction flask to 40°C for 30 minutes, then add 10 parts by mass of glucosamine hydrochloride. Reduce the internal pressure of the reaction flask to 0.05 MPa, stir magnetically for 5 minutes, heat in an oil bath to 75°C, and react for 2 hours. After the reaction, filter the resulting product under reduced pressure, then rinse with water, dissolve, collect, and concentrate under reduced pressure using a rotary evaporator. Place in an oven at 105°C to quickly dry the product to obtain a crude product.

[0102] The crude product was extracted, and after standing for separation, the aqueous phase was separated and collected using a separatory funnel. The aqueous solution obtained by extraction was then neutralized with a 10 wt % sodium hydroxide solution to a pH of 7, concentrated by reduced pressure distillation using a rotary evaporator, and then transferred to a vacuum oven and dried at 50° C. to obtain an alkyl glycoside.

[0103] S2: Preparation of the Psoralea corylifolia extract

[0104] S2.1: Mix the alkyl glycoside and water at a material-liquid ratio of 1 g:20 mL to obtain an alkyl glycoside solution;

[0105] S2.2: Weigh the dried leaves of Scutellaria baicalensis, crush them into 60-mesh pieces, mix the crushed leaves with water at a material-liquid ratio of 1 g:10 mL to obtain a Scutellaria baicalensis extract, mix the alkyl glycoside solution and the Scutellaria baicalensis extract at a mass ratio of 1:1, and microwave-extract for 5 min in a microwave extractor preheated to 60°C to obtain a Scutellaria baicalensis extract. In the subsequent steps, the alkyl glycoside solution is used instead of the acylated alkyl glucoside solution, and the remaining steps remain unchanged.

[0106] Comparative Example 2:

[0107] Compared with Example 1, the difference of Comparative Example 2 is that, instead of adding acylated alkyl glucoside in step S2, surfactant sodium dodecyl sulfate is added, specifically "S2.2: weigh the dried Cynanchum sibiricum leaves and crush them into 60 mesh, mix the crushed Cynanchum sibiricum leaves with water at a material-liquid ratio of 1 g:10 mL to obtain Cynanchum sibiricum extract, mix sodium dodecyl sulfate and Cynanchum sibiricum extract at a mass ratio of 1:1, put them into a microwave extractor preheated to 60°C for microwave extraction for 5 minutes, and obtain Cynanchum sibiricum extract", and the other steps remain unchanged.

[0108] Comparative Example 3:

[0109] Compared with Example 1, Comparative Example 3 is different in that no acylated alkyl glucoside is added in step S3. Specifically, “S3.1: dissolving 1 part by mass of oleic acid in 4 parts by mass of 0.1 mol / L NaOH solution, stirring at 400 r / min for 15 minutes to obtain an oleic acid solution, adjusting the pH value of the system to 6, and magnetically stirring at 400 r / min for 1 hour to obtain vesicles;

[0110] S3.2: mixing naringin and the extract of the Chinese yew tree in a mass ratio of 2:1, and then adding anhydrous ethanol at a mass fraction of 5 wt % to obtain a composite core material;

[0111] S3.3: Inject the composite core material into the vesicles using the ethanol injection method, then remove the ethanol by magnetic stirring at 400 r / min and 75°C for 1 h to obtain a suspension of naringin and Scutellaria baicalensis extract. The remaining steps remain unchanged.

[0112] Comparative Example 4:

[0113] Compared with Example 1, Comparative Example 4 is different in that oleic acid is not added in step S3. Specifically, “S3.1: dissolving 1 part by mass of acylated alkyl glucoside in ethanol and stirring for 5 minutes until completely dissolved, adjusting the pH value of the system to 6, and magnetically stirring at a speed of 400 r / min for 1 hour to obtain vesicles;

[0114] S3.2: mixing naringin and the extract of the Chinese yew tree in a mass ratio of 2:1, and then adding anhydrous ethanol at a mass fraction of 5 wt % to obtain a composite core material;

[0115] S3.3: Inject the composite core material into the vesicles using the ethanol injection method, then remove the ethanol by magnetic stirring at 400 r / min and 75°C for 1 h to obtain a suspension of naringin and Scutellaria baicalensis extract. The remaining steps remain unchanged.

[0116] The flavonoid content in the extracts of the Herba Lycoris Radiatae of Examples 1-3 and Comparative Examples 1-2 was determined, and the extraction rate of the Herba Lycoris Radiatae flavonoids was calculated, as shown in Table 1.

[0117] Among them, the content of flavonoids in the Scutellaria baicalensis extract (%) = the mass of flavonoids in the Scutellaria baicalensis extract / the mass of the Scutellaria baicalensis extract*100%.

[0118] The encapsulation efficiency of the suspensions of naringin and the extract of the Herba Citri Reticulatae in Examples 1-3 and Comparative Examples 3-4 was determined, as shown in Table 2.

[0119] Among them, the encapsulation rate (%) = (the amount of naringin and Glechoma longituba extract input - the content of naringin and Glechoma longituba in the suspension of naringin and Glechoma longituba extract) / the amount of naringin and Glechoma longituba extract input * 100%.

[0120]

[0121] As can be seen from Table 1, the flavonoid content in the extracts of the Scutellaria baicalensis in Examples 1-3 exceeds 46.03%, which is much higher than 34.46% and 38.14% in the comparative examples. It can be seen that the acylated alkyl glucoside used in the present invention to extract flavonoids from the Scutellaria baicalensis is better than conventional surfactants and alkyl glucosides.

[0122] As can be seen from Table 2, the encapsulation efficiency of Examples 1-3 is above 58.31%, which is better than 45.17% of Comparative Example 3 and 43.69% of Comparative Example 4, indicating that the composite vesicles after the acylated alkyl glucoside and oleic acid are combined have better encapsulation effect than the single material.

[0123] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the present invention. Anyone skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by one of ordinary skill in the art without departing from the spirit and technical principles disclosed herein are intended to be covered by the claims of the present invention.

Claims

1. A method for preparing a traditional Chinese medicine skin care cream for repairing skin, characterized in that: The steps include: S1: Preparation of acylated alkyl glucoside S1.1: Mix 1-2 parts by weight of alkyl glycoside and 10-20 parts by weight of myristic acid, stir magnetically at 300-350 rpm for 12-13 hours, and heat to 50-55°C. Then, add 100 mg / mL of 4A molecular sieves and 20-25 mg / mL of lipase, and react for 24-26 hours. S1.2: After the reaction is complete, the product is centrifuged at 11,000-12,000 rpm at 4°C for 7-10 minutes. Finally, the product is filtered through a membrane to remove the lipase and molecular sieves to obtain the acylated alkyl glucoside. S2: Preparation of the Psoralea corylifolia extract S2.1: Mix the acylated alkyl glucoside with water at a solid-liquid ratio of 1 g:(20-30) mL to obtain an acylated alkyl glucoside solution; S2.2: Weigh the dried leaves of Scutellaria baicalensis, crush them into 60-mesh pieces, mix the leaves with water at a material-liquid ratio of 1 g:(10-20) mL to obtain a Scutellaria baicalensis extract, mix the acylated alkyl glucoside solution and the Scutellaria baicalensis extract at a mass ratio of 1:(1-5), and microwave-extract for 5-20 minutes in a microwave extractor preheated to 60-70°C to obtain a Scutellaria baicalensis extract. S3: Preparation of naringin and scutellaria baicalensis extract suspension S3.1: Dissolve 1-2 parts by mass of oleic acid in 4-8 parts by mass of 0.1-0.2 mol / L NaOH solution and stir at 400 rpm for 15-20 minutes to obtain an oleic acid solution; S3.2: Dissolve 1-2 parts by mass of acylated alkyl glucoside in ethanol and stir for 5-10 minutes until completely dissolved. Then, add an equal volume of oleic acid solution and adjust the pH of the system to 6-6.

5. Magnetic stirring is continued at 400-450 rpm for 1-1.5 hours to obtain composite vesicles. S3.3: mixing naringin and the extract of the Chinese yew tree in a mass ratio of (2-2.5):1, and then adding anhydrous ethanol in a mass fraction of 5-15 wt % to obtain a composite core material; S3.4: Injecting the composite core material into the composite vesicles using an ethanol injection method, and then removing the ethanol by magnetic stirring at a speed of 400-450 rpm and an environment of 75-80°C for 1-1.5 hours to obtain a suspension of naringin and the scutellaria baicalensis extract; S4: Preparation of traditional Chinese medicine skin care cream for skin repair Carbomer, glycerin, sclerotium gum, naringin, a suspension of the scutellaria baicalensis extract and deionized water are mixed and stirred evenly, and triethanolamine is added dropwise and subjected to swelling treatment to obtain a traditional Chinese medicine skin care cream for repairing skin.

2. A method for preparing a traditional Chinese medicine skin care cream for repairing skin according to claim 1, characterized in that, Step S4 is preparing a Chinese medicine skin care cream for repairing skin, comprising the following steps: S4.1: Mix 1-3 wt% carbomer, 5-8 wt% glycerol, 4-8 wt% sclerotium gum, and 40-50 wt% naringin with the suspension of the Scutellaria baicalensis extract and deionized water, stirring uniformly at 100-150 rpm for 30-35 min. S4.2: Add an appropriate amount of triethanolamine to adjust the pH to 6-7, let it stand for 12-14 hours to allow it to swell, then add 50% of the system mass of deionized water, stir for 30-35 minutes, and obtain a traditional Chinese medicine skin care cream for repairing skin.

3. A method for preparing a traditional Chinese medicine skin care cream for repairing skin according to claim 1, characterized in that, The specific preparation steps of alkyl glycoside are: Preheat 15-25 parts by mass of n-octanol and 0.5-1 parts by mass of an acid catalyst in a reaction flask to 40-50°C for 30-35 minutes, then add 10-20 parts by mass of glucosamine hydrochloride, reduce the internal pressure of the reaction flask to 0.05-0.08 MPa, stir magnetically for 5-10 minutes, heat in an oil bath to 75-80°C, and react for 2-3 hours. After the reaction is completed, filter the reaction product under reduced pressure, then rinse with water, dissolve and collect, and concentrate by reduced pressure distillation on a rotary evaporator. Place in an oven at 105-110°C to quickly dry the water to obtain a crude product. The crude product was extracted, allowed to stand and decomposed, and the resulting aqueous phase was separated and collected using a separatory funnel. The aqueous solution obtained by extraction was then neutralized with a 10 wt % sodium hydroxide solution to a pH of 7-7.5, concentrated by reduced pressure distillation using a rotary evaporator, and then transferred to a vacuum oven for drying at 50-55° C. to obtain an alkyl glycoside.

4. The method for preparing a traditional Chinese medicine skin care cream for repairing skin according to claim 1, wherein: The lipase is specifically Lipozyme 435 enzyme.

5. A method for preparing a traditional Chinese medicine skin care cream for repairing skin according to claim 1, characterized in that, The filtration diameter of the filter membrane is 0.22 μm.

6. A Chinese medicine skin care cream for repairing skin, characterized in that: The skin-repairing cream is prepared by the method for preparing the traditional Chinese medicine skin-repairing cream according to any one of claims 1 to 5.

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