Antioxidant coenzyme Q10 capsule and preparation method thereof

Abstract

The present invention discloses an antioxidant coenzyme Q10 capsule and a preparation method thereof, belonging to the field of health care products. The coenzyme Q10 capsule contains an antioxidant composition comprising coenzyme Q10, Herba Euphorbiae Herba Extracts, Citronellol Peel Extracts, and Phellodendron Chinense Fruit Extracts. The combination of coenzyme Q10, Herba Euphorbiae Herba Extracts, Citronellol Peel Extracts, and Phellodendron Chinense Fruit Extracts creates a synergistic effect, thereby achieving an excellent antioxidant effect.

Description

Technical Field

[0001] The present invention relates to the field of health care products, and in particular to an antioxidant coenzyme Q10 capsule and a preparation method thereof. Background Art

[0002] Coenzyme Q10 itself is a naturally occurring fat-soluble quinone compound with a structure similar to vitamin K, vitamin E, and plastoquinone. It participates in energy production and activation within human cells and is the most effective antioxidant for preventing the formation of arteriosclerosis. Coenzyme Q10 has two primary functions in the body: first, it plays a vital role in the conversion of nutrients into energy within mitochondria, and second, it has a significant anti-lipid peroxidation effect. However, with aging, the body's ability to synthesize Coenzyme Q10 decreases. Therefore, supplementing with Coenzyme Q10 capsules can effectively boost immunity, enhance antioxidant capacity, slow aging, and enhance vitality.

[0003] While Coenzyme Q10 has significant antioxidant effects, it has some drawbacks, such as low in vivo absorption and its antioxidant activity primarily concentrated within mitochondria, with limited antioxidant activity outside of cells. Flavonoids, phenolic compounds, and terpenes found in plant extracts possess strong antioxidant effects and high absorption rates. Therefore, there is a need for a composition comprising Coenzyme Q10 and plant extracts that can synergistically achieve superior antioxidant efficacy by leveraging the combined effects of Coenzyme Q10 and plant extracts. Summary of the Invention

[0004] The present invention aims to provide an antioxidant coenzyme Q10 capsule and a preparation method thereof. The capsule contains an antioxidant composition, which is prepared using coenzyme Q10, Euphorbia euphorbia extract, pomelo peel extract, and Phellodendron chinense fruit extract as raw materials and has excellent antioxidant effect.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] In a first aspect, the present invention provides an antioxidant composition comprising the following ingredients: coenzyme Q10, Euphorbia pulegosa extract, pomelo peel extract, and Phellodendron chinense fruit extract.

[0007] The antioxidant composition comprises the following raw materials in parts by mass:

[0008] Coenzyme Q10: 3-5 parts;

[0009] Euphorbia pulegosa L. extract: 10-15 parts;

[0010] Grapefruit peel extract: 20-25 parts;

[0011] Phellodendron chinense fruit extract: 30-50 parts.

[0012] Furthermore, the antioxidant composition comprises the following raw materials in parts by mass:

[0013] Coenzyme Q10: 4-5 parts;

[0014] Euphorbia pulegosa L. extract: 10-13 parts;

[0015] Grapefruit peel extract: 20-23 parts;

[0016] Phellodendron chinense fruit extract: 40-50 parts.

[0017] Most preferably, the antioxidant composition comprises the following raw materials in parts by mass:

[0018] Coenzyme Q10: 4 parts;

[0019] Euphorbia pulegosa L. extract: 13 parts;

[0020] Grapefruit peel extract: 23 parts;

[0021] Phellodendron chinense fruit extract: 40 parts.

[0022] In a second aspect, the present invention provides an antioxidant coenzyme Q10 capsule, comprising capsule contents and a capsule shell, wherein the capsule contents include the following components in mass percentage:

[0023] The antioxidant composition of the first aspect: 50-70 wt%;

[0024] Drinking water was added to make up to 100 wt%.

[0025] Preferably, the capsule shell is a soft capsule shell or a hard capsule shell.

[0026] More preferably, the capsule shell is a soft capsule shell.

[0027] In a third aspect, the present invention provides a method for preparing the antioxidant coenzyme Q10 capsule according to the second aspect, the preparation method comprising the following steps:

[0028] S1: Mixing Euphorbia euphorbiae extract, Citrus grandiflora peel extract, and Phellodendron chinense fruit extract with half of the drinking water to obtain a mixed solution A;

[0029] S2: Mixing coenzyme Q10 and remaining drinking water to obtain mixed solution B;

[0030] S3: Mixing the mixed solution A and the mixed solution B, and ultrasonically shaking to obtain the capsule contents;

[0031] S4: placing the capsule contents in a fully automatic soft capsule machine to prepare a soft capsule preparation, sterilizing the soft capsule preparation, sealing it, and storing it at room temperature away from light.

[0032] Compared with the prior art, the present invention has the following beneficial effects: the present invention provides an antioxidant coenzyme Q10 capsule and a preparation method thereof, the capsule comprising an antioxidant composition, the antioxidant composition being compounded by coenzyme Q10, Herba Euphorbiae Herba Extract, Citronelloides Peel Extract, and Phellodendron Amurense Extract; research has found that there is a synergistic effect between coenzyme Q10 and Herba Euphorbiae Herba Extract, Citronelloides Peel Extract, and Phellodendron Amurense Extract, specifically: on the one hand, Herba Euphorbiae Herba Extract, Citronelloides Peel Extract, and Phellodendron Amurense Extract are rich in a variety of flavonoids, polyphenols, and terpenoids, which can act in different pathways and jointly exert antioxidant effects; on the other hand, coenzyme Q10 has excellent electron transfer and free radical scavenging effects, and it synergizes with the polyphenols and flavonoids in Herba Euphorbiae Herba Extract, Citronelloides Peel Extract, and Phellodendron Amurense Extract, complementing each other in the antioxidant mechanism and jointly improving the antioxidant effect. DETAILED DESCRIPTION

[0033] In order to better understand the present invention, the present invention is further described below in conjunction with specific application examples, wherein the terms used in the application examples are for describing specific embodiments and do not constitute a limitation on the scope of protection of the present invention.

[0034] In the following examples, the experimental methods without specific conditions are generally based on conventional conditions or the conditions recommended by the manufacturer. Unless otherwise specified, the percentages and parts by mass are calculated.

[0035] Some of the raw materials and their sources are as follows:

[0036] Coenzyme Q10: purchased from Shandong Huiheng Biotechnology Co., Ltd.

[0037] Euphorbia euphorbia extract: purchased from Shanyang Lianfeng Biotechnology Co., Ltd.

[0038] Grapefruit peel extract: purchased from Guangdong Mingcheng Biotechnology Co., Ltd.

[0039] Phellodendron chinense fruit extract: purchased from Ningxia Vanilla Biotechnology Co., Ltd.

[0040] Fully automatic soft capsule machine: ZTHT-125 fully automatic soft capsule machine, purchased from Beijing Zhongtian Huitong Technology Co., Ltd.

[0041] The components of the antioxidant composition and their weight ratios are shown in Table 1.

[0042] Table 1 Components of the antioxidant composition and their mass ratios

[0043]

[0044]

[0045] The components and their mass percentages of the antioxidant coenzyme Q10 capsules are shown in Table 2.

[0046] Table 2 Components and mass percentages of antioxidant coenzyme Q10 capsules

[0047]

[0048] The preparation methods of the above application examples 1-5 are as follows:

[0049] S1: Mixing Euphorbia euphorbiae extract, Citrus grandiflora peel extract, and Phellodendron chinense fruit extract with half of the drinking water to obtain a mixed solution A;

[0050] S2: Mix the coenzyme Q10 and the remaining drinking water to obtain a mixture B;

[0051] S3: Mixing the mixed solution A and the mixed solution B, and ultrasonically shaking to obtain the contents of the capsule. The ultrasonic shaking frequency is 60 kHz and the ultrasonic time is 5 minutes;

[0052] S4: Place the capsule contents in a fully automatic soft capsule machine to prepare a capsule preparation, sterilize the capsule preparation, seal it, and store it at room temperature away from light.

[0053] Among them, the capsule preparation described in S4 is a gelatin soft capsule preparation, and the gelatin soft capsule shell is made of gelatin, glycerin and water with a mass ratio of 1:0.35:0.8.

[0054] Antioxidant assay

[0055] Experiment 1: Antioxidant test in mice

[0056] Healthy adult KM mice weighing 20-30 g were selected and adaptively fed for 5 days. According to the experimental requirements, they were divided into 1 normal control group, 1 model control group, and 10 sample groups, with 9 mice in each group. The model control group and sample group used modeling mice, and the normal control group used normal mice.

[0057] Sample concentration: Compositions 1-3, ①-⑦ were prepared with drinking water to form a 60 wt% sample solution.

[0058] Modeling method: The model was established according to the D-galactose oxidative damage model specified in the National Food and Drug Administration

[2012] No. 107 "Antioxidant Function Evaluation Method".

[0059] Oral administration concentration: Feed mice with ten times the daily dose of 8.33 mg / kg for adults (60 kg). The feeding dose for mice is 0.75 g / kg, once a day for 3 days. The dose conversion coefficient between mice and humans is 9.01.

[0060] Experimental Methods: Model mice were gavaged with the drug sample at 0.75g / kg, while the model control and blank control groups were gavaged with an equal volume of drinking water. After the gavage, tail venous blood was collected and assayed for MDA and SOD. The test results are shown in Table 3.

[0061] Test 2: In vitro antioxidant test

[0062] Test sample concentration: Compositions 1-3, ①-⑦ were prepared with drinking water to form a 60 wt% sample solution.

[0063] Positive control group: Vitamin C, prepared in drinking water at 0.03 mg / mL.

[0064] Test method: Refer to the test kit instructions.

[0065] The total antioxidant capacity (DPPH method) test kit used was purchased from Shanghai ELISA Biotechnology Co., Ltd., catalog number ml092650. The test results are shown in Table 3.

[0066] Table 3 Antioxidant test results

[0067]

[0068] Note: “#” indicates comparison with the model control group, p < 0.05; “*” indicates comparison with the blank control group, p < 0.05; “a” indicates comparison with composition 1, p < 0.05; “b” indicates comparison with the positive control group, p < 0.05; “-” indicates blank.

[0069] Result analysis:

[0070] 1. Analysis of the results of the mouse antioxidant test

[0071] Comparison of the results of compositions 1-3 with the model control group shows that the antioxidant composition of the present invention has significant antioxidant efficacy.

[0072] Comparing the results of composition 1 with compositions ①-④, it can be seen that there is a significant synergistic effect among coenzyme Q10, Euphorbia euphorbiae extract, pomelo peel extract, and Phellodendron chinense fruit extract in the present invention.

[0073] Comparing the results of composition 1 with compositions ⑤-⑦, it can be seen that within the dosage range specified in the present invention, there is a significant synergistic effect between coenzyme Q10, Euphorbia euphorbiae extract, pomelo peel extract, and Phellodendron chinense fruit extract.

[0074] 2. Analysis of in vitro antioxidant test results

[0075] Comparing the results of compositions 1-3 with the positive control group, it can be seen that the antioxidant composition of the present invention has significant antioxidant efficacy.

[0076] Comparing the results of composition 1 with compositions ①-④, it can be seen that there is a significant synergistic effect among coenzyme Q10, Euphorbia euphorbiae extract, pomelo peel extract, and Phellodendron chinense fruit extract in the present invention.

[0077] Comparing the results of composition 1 with compositions ⑤-⑦, it can be seen that within the dosage range specified in the present invention, there is a significant synergistic effect between coenzyme Q10, Euphorbia euphorbiae extract, pomelo peel extract, and Phellodendron chinense fruit extract.

[0078] The embodiments described above are some embodiments of the present invention, rather than all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but merely represents selected embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

Claims

1. An antioxidant composition, characterized in that The composition is composed of the following raw materials in parts by mass: Coenzyme Q10: 3-5 parts; Euphorbia pulegosa L. extract: 10-15 parts; Grapefruit peel extract: 20-25 parts; Phellodendron chinense fruit extract: 30-50 parts.

2. The composition according to claim 1, characterized in that The composition is composed of the following raw materials in parts by mass: Coenzyme Q10: 4 parts; Euphorbia pulegosa L. extract: 13 parts; Grapefruit peel extract: 23 parts; Phellodendron chinense fruit extract: 40 parts.

3. Use of the antioxidant composition according to claim 1 or 2 in the preparation of health products.

4. The application according to claim 3, characterized in that The health product is an antioxidant product.

5. An antioxidant product according to claim 4, characterized in that The antioxidant product is in the form of any one of capsules, tablets, and oral liquid.

6. An antioxidant coenzyme Q10 capsule, characterized in that: The capsule comprises capsule contents and a capsule shell, wherein the capsule contents comprise the following components in mass percentage: The antioxidant composition according to claim 1 or 2: 50-70wt%; Drinking water was added to 100 wt%.

7. A method for preparing the antioxidant coenzyme Q10 capsule according to claim 6, characterized in that: The preparation method comprises the following steps: S1: Mix the Herba Euphorbiae Ichthyophthirius extract, the Citronella citron peel extract, the Phellodendron chinense fruit extract and 1 / 2 drinking water to obtain a mixed solution A; S2: Mixing coenzyme Q10 and remaining drinking water to obtain mixed solution B; S3: Mixing the mixed solution A and the mixed solution B, and ultrasonically shaking to obtain the capsule contents; S4: placing the capsule contents in a fully automatic soft capsule machine to prepare a soft capsule preparation, sterilizing the soft capsule preparation, sealing it, and storing it at room temperature away from light.

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