Urea pyrimidine compound containing sulfonyl and application thereof

Abstract

The invention discloses a sulfonyl-containing uracil compound and an application thereof. The structure of the compound is shown as a general formula I, wherein the definition of each substituent group in a # imgabs0 # formula is shown in the specification; also disclosed in the specification are their use as herbicides.

Description

Technical Field

[0001] The present invention belongs to the field of agricultural herbicides, and specifically relates to a sulfonyl-containing uracil compound and its application. Background Art

[0002] Weed control is a crucial link in achieving efficient agricultural production. Although there are various types of herbicides on the market, the weed control performance of these known compounds against harmful plants and the selectivity for crops are not completely satisfactory. In addition, due to the continuous expansion of the market, weed resistance, service life of drugs, economic efficiency of drugs and other issues as well as people's increasing attention to the environment, it is necessary to continuously research and develop new varieties of herbicides that are efficient, safe, economical and have different modes of action.

[0003] In the prior art, there is no report on the uracil compounds and their herbicidal activities as shown in the present invention. Summary of the invention

[0004] In order to develop a new herbicide to solve the increasingly serious problem of herbicide resistance, the present invention provides a sulfonyl-containing uracil compound and application thereof.

[0005] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0006] A sulfonyl-containing uracil compound, as shown in the general formula I:

[0007]

[0008] In the general formula I:

[0009] Y is selected from Y 1 -Y 11 One of the groups shown:

[0010]

[0011] R 1 , R 2 are each independently selected from hydrogen, halogen, nitro, amino, cyano, C 1 -C 6 Alkyl or halogenated C 1 -C 6 alkyl;

[0012] R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R12 and R 13 are each independently selected from hydrogen, C 1 -C 6 alkyl or halo-C 1 -C 6 alkyl;

[0013] X 1 , X 2 , X 3 , X 4 , X 5 , X 6 are each independently selected from hydrogen, halogen, cyano, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl; or, X 1 and X 2 together form a C 3 -C 8 cycloalkyl; or, X 3 and X 4 together form a C 3 -C 8 cycloalkyl; or, X 5 and X 6 together form a C 3 -C 8 cycloalkyl;

[0014] n is selected from 0, 1 or 2;

[0015] Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , Q 7 , Q 8 , Q 9 , Q 10 are each independently selected from hydrogen, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, cyano-C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, allyl, propargyl, C 1 -C 6 alkylcarbonyl, halo-C 1 -C 6 alkylcarbonyl, C3 -C 8 Cycloalkylcarbonyl, C 1 -C 6 Alkoxycarbonyl, C 2 -C 8 Alkenylcarbonyl, C 2 -C 8 Alkynylcarbonyl, C 1 -C 6 Alkoxy C 1 -C 6 Alkylcarbonyl, C 1 -C 6 Alkoxycarbonyl C 1 -C 6 Alkylcarbonyl, C 1 -C 6 Alkoxycarbonyl C 1 -C 6 Alkyl, C 1 -C 6 Alkylsulfonyl, halo C 1 -C 6 Alkylsulfonyl, C 3 -C 8 Cycloalkylsulfonyl,

[0016] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 6 Alkyl, halogenated C 1 -C 6 Alkyl, C 1 -C 6 Alkoxy, halogenated C 1 -C 6 Alkoxy, C 1 -C 6 Alkylthio or halogenated C 1 -C 6 Alkylthio;

[0017] or a stereoisomer of the compound of formula I;

[0018] or a salt of a compound of formula I;

[0019] or a salt of a stereoisomer of a compound of formula I.

[0020] In a possible implementation, in the general formula I,

[0021] Y is selected from Y 1-Y 11 One of the groups shown;

[0022] R 1 and R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 alkyl or halo C 1 -C 4 alkyl;

[0023] R 3 and R 4 and R 5 and R 6 and R 7 and R 8 and R 9 and R 10 and R 11 and R 12 and R 13 are each independently selected from hydrogen, C 1 -C 4 alkyl or halo C 1 -C 4 alkyl;

[0024] X 1 and X 2 and X 3 and X 4 and X 5 and X 6 are each independently selected from hydrogen, halogen, cyano, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl; or, X 1 and X 2 together form a C 3 -C 6 cycloalkyl; or, X 3 and X 4 together form a C 3 -C 6 cycloalkyl; or, X 5 and X 6 together form a C 3 -C 6 cycloalkyl;

[0025] n is selected from 0, 1 or 2;

[0026] Q 1 and Q 2 and Q 3 and Q 4 and Q 5 and Q 6 and Q 7 and Q 8, Q 9 , Q 10 are each independently selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 3 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 3 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 3 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0027] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0028] or a stereoisomer of the compound of formula I;

[0029] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0030] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0031] In a possible implementation, in the general formula I,

[0032] Y is selected from Y 1 -Y 11 One of the groups shown;

[0033] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0034] R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 are each independently selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0035] X 1 , X 2 , X 3 , X 4 , X 5, X 6 are each independently selected from hydrogen, halogen, cyano, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl; or, X 1 With X 2 Together they form C 3 -C 6 Cycloalkyl; or, X 3 With X 4 Together they form C 3 -C 6 Cycloalkyl; or, X 5 With X 6 Together they form C 3 -C 6 Cycloalkyl;

[0036] n is selected from 0, 1 or 2;

[0037] Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , Q 7 , Q 8 , Q 9 , Q 10 are each independently selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0038] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0039] or a stereoisomer of the compound of formula I;

[0040] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0041] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0042] In a possible implementation, in the general formula I,

[0043] Y is selected from Y 1 -Y 11 One of the groups shown;

[0044] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0045] R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 each independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0046] X 1 , X 2 , X 3 , X 4 , X 5 , X 6 are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 1 With X 2 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; or, X 3 With X 4 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; or, X 5 With X 6 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl;

[0047] n is selected from 0, 1 or 2;

[0048] Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , Q 7, Q 8 , Q 9 , Q 10 each independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, Cyclopentylpropyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl , cyclohexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl , t-Butylcarbonyl, t-Butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, t-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0049] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0050] or a stereoisomer of the compound of formula I;

[0051] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0052] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0053] In a possible implementation, in the general formula I,

[0054] Y is selected from Y 1 ;

[0055] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0056] R 3 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0057] X 1 , X 2 are each independently selected from hydrogen, halogen, cyano, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl; or, X 1 With X 2Together they form C 3 -C 6 Cycloalkyl;

[0058] Q 1 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0059] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1-C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0060] or a stereoisomer of the compound of formula I;

[0061] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0062] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0063] In a possible implementation, in the general formula I,

[0064] Y is selected from Y 1 ;

[0065] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0066] R 3 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0067] X 1 , X 2are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 1 With X 2 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl;

[0068] Q 1 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0069] W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0070] or a stereoisomer of the compound of formula I;

[0071] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0072] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0073] In a possible implementation, in the general formula I,

[0074] Y is selected from Y 2 ;

[0075] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0076] R 4 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0077] X 3 , X4 are each independently selected from hydrogen, halogen, cyano, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl; or, X 3 With X 4 Together they form C 3 -C 6 Cycloalkyl;

[0078] Q 2 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0079] W 1 , W2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0080] or a stereoisomer of the compound of formula I;

[0081] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0082] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0083] In a possible implementation, in the general formula I,

[0084] Y is selected from Y 2 ;

[0085] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0086] R 4 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0087] X 3 , X4 are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 3 With X 4 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl;

[0088] Q 2is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0089] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0090] or a stereoisomer of the compound of formula I;

[0091] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0092] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0093] In a possible implementation, in the general formula I,

[0094] Y is selected from Y 3 ;

[0095] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0096] R 5 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0097] X 5 , X 6 are each independently selected from hydrogen, halogen, cyano, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl; or, X 5 With X 6Together they form C 3 -C 6 Cycloalkyl;

[0098] Q 3 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0099] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1-C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0100] or a stereoisomer of the compound of formula I;

[0101] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0102] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0103] In a possible implementation, in the general formula I,

[0104] Y is selected from Y 3 ;

[0105] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0106] R 5 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0107] X 5 , X 6are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 5 With X 6 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl;

[0108] Q 3 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0109] W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0110] or a stereoisomer of the compound of formula I;

[0111] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0112] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0113] In a possible implementation, in the general formula I,

[0114] Y is selected from Y 4 ;

[0115] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0116] R 6 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0117] Q 4 Selected from hydrogen, C1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0118] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0119] or a stereoisomer of the compound of formula I;

[0120] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0121] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0122] In a possible implementation, in the general formula I,

[0123] Y is selected from Y 4 ;

[0124] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0125] R 6 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0126] Q 4is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0127] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0128] or a stereoisomer of the compound of formula I;

[0129] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0130] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0131] In a possible implementation, in the general formula I,

[0132] Y is selected from Y 5 ;

[0133] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0134] R 7 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0135] Q 5 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0136] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0137] or a stereoisomer of the compound of formula I;

[0138] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0139] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0140] In a possible implementation, in the general formula I,

[0141] Y is selected from Y 5 ;

[0142] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0143] R 7 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0144] Q 5is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0145] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0146] or a stereoisomer of the compound of formula I;

[0147] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0148] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0149] In a possible implementation, in the general formula I,

[0150] Y is selected from Y 6 ;

[0151] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0152] R 8 , R 9 are each independently selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0153] Q 6 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0154] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0155] or a stereoisomer of the compound of formula I;

[0156] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0157] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0158] In a possible implementation, in the general formula I,

[0159] Y is selected from Y 6 ;

[0160] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0161] R 8 , R 9 each independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0162] Q 6is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0163] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0164] or a stereoisomer of the compound of formula I;

[0165] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0166] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0167] In a possible implementation, in the general formula I,

[0168] Y is selected from Y 7 ;

[0169] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0170] R 10 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0171] n is selected from 0, 1 or 2;

[0172] or a stereoisomer of the compound of formula I;

[0173] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0174] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0175] In a possible implementation, in the general formula I,

[0176] Y is selected from Y 7 ;

[0177] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0178] R 10 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0179] n is selected from 0, 1 or 2;

[0180] or a stereoisomer of the compound of formula I;

[0181] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0182] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0183] In a possible implementation, in the general formula I,

[0184] Y is selected from Y8 ;

[0185] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0186] R 11 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0187] Q 7 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C6 Cycloalkylsulfonyl,

[0188] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0189] or a stereoisomer of the compound of formula I;

[0190] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0191] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0192] In a possible implementation, in the general formula I,

[0193] Y is selected from Y 8 ;

[0194] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0195] R 11is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0196] Q 7 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0197] W 1 , W2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0198] or a stereoisomer of the compound of formula I;

[0199] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0200] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0201] In a possible implementation, in the general formula I,

[0202] Y is selected from Y 9 ;

[0203] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0204] Q 8 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0205] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0206] or a stereoisomer of the compound of formula I;

[0207] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0208] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0209] In a possible implementation, in the general formula I,

[0210] Y is selected from Y 9 ;

[0211] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0212] Q 8is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0213] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0214] or a stereoisomer of the compound of formula I;

[0215] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0216] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0217] In a possible implementation, in the general formula I,

[0218] Y is selected from Y 10 ;

[0219] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0220] R 12 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0221] Q 9 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0222] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0223] or a stereoisomer of the compound of formula I;

[0224] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0225] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0226] In a possible implementation, in the general formula I,

[0227] Y is selected from Y 10 ;

[0228] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0229] R 12 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0230] Q 9is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0231] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0232] or a stereoisomer of the compound of formula I;

[0233] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0234] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0235] In a possible implementation, in the general formula I,

[0236] Y is selected from Y 11 ;

[0237] R 1 , R 2 are each independently selected from hydrogen, halogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0238] R 13 Selected from hydrogen, C 1 -C 4 Alkyl or halogenated C 1 -C 4 alkyl;

[0239] Q 10 Selected from hydrogen, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, cyano C 1 -C 4 Alkyl, C 3 -C 6Cycloalkyl, C 3 -C 6 Cycloalkyl C 1 -C 4 Alkyl, allyl, propargyl, C 1 -C 4 Alkylcarbonyl, haloC 1 -C 4 Alkylcarbonyl, C 3 -C 6 Cycloalkylcarbonyl, C 1 -C 4 Alkoxycarbonyl, C 2 -C 4 Alkenylcarbonyl, C 2 -C 4 Alkynylcarbonyl, C 1 -C 4 Alkoxy C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkylcarbonyl, C 1 -C 4 Alkoxycarbonyl C 1 -C 2 Alkyl, C 1 -C 4 Alkylsulfonyl, halo C 1 -C 4 Alkylsulfonyl, C 3 -C 6 Cycloalkylsulfonyl,

[0240] W 1 , W 2 , W 3 , W 4 , W 5 are each independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C 1 -C 4 Alkyl, halogenated C 1 -C 4 Alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 Alkoxy, C 1 -C 4 Alkylthio or halogenated C 1 -C 4 Alkylthio;

[0241] or a stereoisomer of the compound of formula I;

[0242] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0243] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0244] In a possible implementation, in the general formula I,

[0245] Y is selected from Y 10 ;

[0246] R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0247] R 13 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl;

[0248] Q 10is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl,

[0249] W 1 , W 2 , W 3 , W 4 , W 5each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio;

[0250] or a stereoisomer of the compound of formula I;

[0251] or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid;

[0252] or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

[0253] In the definitions of the compounds of the general formula given above, the terms used collectively generally represent the following substituents:

[0254] Halogen: refers to fluorine, chlorine, bromine or iodine.

[0255] Alkyl: straight-chain or branched alkyl, for example methyl, ethyl, n-propyl, isopropyl or the different butyl, pentyl or hexyl isomers.

[0256] Haloalkyl: a straight or branched chain alkyl group, in which the hydrogen atoms may be partially or completely substituted by halogen, for example, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl.

[0257] Cycloalkyl: substituted or unsubstituted cyclic alkyl, such as cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; substituents such as methyl, halogen, etc.

[0258] Cycloalkylalkyl: a substituted or unsubstituted cyclic alkyl group attached to the structure via a straight chain alkyl group, for example, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylpropyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl or cyclohexylbutyl, etc.

[0259] Cyanoalkyl: a straight or branched chain alkyl group in which some or all of the hydrogen atoms are replaced by cyano groups, such as cyanomethyl (CNCH 2 -), cyanoethyl (CNCH 2 CH 2 -), cyanopropyl (CNCH 2 CH 2 CH 2 -) or cyanobutyl (CNCH 2 CH 2 CH 2 CH 2 -).

[0260] Alkoxy: A straight or branched chain alkyl group connected to the structure via an oxygen atom bond, such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy or tert-butoxy.

[0261] Haloalkoxy: a straight-chain or branched alkoxy group, in which the hydrogen atoms may be partially or completely replaced by halogen, such as fluoromethoxy, difluoromethoxy, trifluoromethoxy or 2,2,2-trifluoroethoxy.

[0262] Alkylthio: A straight or branched chain alkyl group connected to the structure via a sulfur atom bond, such as methylthio or ethylthio.

[0263] Haloalkylthio: a straight-chain or branched alkylthio group, in which the hydrogen atoms may be partially or completely substituted by halogen, such as difluoromethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio.

[0264] Alkylcarbonyl: An alkyl group is attached to the structure via a carbonyl group, such as methylcarbonyl (CH 3 CO-), ethylcarbonyl (CH 3 CH 2 CO-), n-propylcarbonyl (CH 3 CH 2 CH 2 CO-), isopropylcarbonyl ((CH 3 ) 2 CHCO-), n-butylcarbonyl (CH 3 CH 2 CH 2 CH 2CO-), isobutylcarbonyl (CH 3 CH(CH 3 ) 2 CO-), sec-butylcarbonyl (CH 3 CH 2 CH(CH 3 )CO-) or tert-butylcarbonyl ((CH 3 ) 3 CCO-) etc.

[0265] Haloalkylcarbonyl: The hydrogen atoms on the alkyl group of the alkylcarbonyl group may be partially or completely substituted by halogen atoms, for example monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl or perfluoroethylcarbonyl.

[0266] Cycloalkylcarbonyl: The cycloalkyl group is attached to the structure via a carbonyl group, for example, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl or cyclohexylcarbonyl, etc.

[0267] Alkoxycarbonyl: alkyl-O-CO-, such as methoxycarbonyl (CH 3 OCO-), ethoxycarbonyl (CH 3 CH 2 OCO-), n-propoxycarbonyl (CH 3 CH 2 CH 2 OCO-), isopropoxycarbonyl ((CH 3 ) 2 CHOCO-), n-butyloxycarbonyl (CH 3 CH 2 CH 2 CH 2 OCO-), isobutyloxycarbonyl (CH 3 CH(CH 3 ) 2 OCO-), sec-butyloxycarbonyl (CH 3 CH 2 CH(CH 3 )OCO-) or tert-butyloxycarbonyl ((CH 3 ) 3 COCO-) etc.

[0268] Alkoxycarbonylalkyl: alkyl-O-CO-alkyl-, for example, wait.

[0269] Alkoxycarbonylalkylcarbonyl: alkyl-O-CO-alkyl-CO-, e.g. wait.

[0270] Alkoxyalkylcarbonyl: alkyl-O-alkyl-CO-, for example methoxymethylcarbonyl (CH 3 OCH 2 CO-), ethoxymethylcarbonyl (CH 3 CH 2 OCH 2 CO-), n-propoxymethylcarbonyl (CH 3 CH 2 CH 2 OCH 2 CO-), isopropoxymethylcarbonyl ((CH 3 ) 2 CHOCH 2 CO-), n-butyloxymethylcarbonyl (CH 3 CH 2 CH 2 CH 2 OCH 2 CO-), isobutyloxymethylcarbonyl (CH 3 CH(CH 3 ) 2 OCH 2 CO-), sec-butoxymethylcarbonyl (CH 3 CH 2 CH(CH 3 )OCH 2 CO-), tert-butoxymethylcarbonyl ((CH 3 ) 3 COCH 2 CO-), methoxyethylcarbonyl (CH 3 OCH 2 CH 2 CO-), ethoxyethylcarbonyl (CH 3 CH 2 OCH 2 CH 2 CO-), n-propoxyethylcarbonyl (CH 3 CH 2 CH 2 OCH 2 CH 2 CO-), isopropoxyethylcarbonyl ((CH 3 ) 2 CHOCH 2 CH 2 CO-), n-butoxyethylcarbonyl (CH 3 CH 2 CH 2 CH 2 OCH 2 CH 2CO-), isobutyloxyethylcarbonyl (CH 3 CH(CH 3 ) 2 OCH 2 CH 2 CO-), sec-butoxyethylcarbonyl (CH 3 CH 2 CH(CH 3 )OCH 2 CH 2 CO-), tert-butoxyethylcarbonyl ((CH 3 ) 3 COCH 2 CH 2 CO-).

[0271] Alkylsulfonyl: a straight chain or branched alkyl sulfonyl group (-SO 2 -) attached to the structure, such as methylsulfonyl (CH 3 SO 2 -), ethylsulfonyl (CH 3 CH 2 SO 2 -), n-propylsulfonyl (CH 3 CH 2 CH 2 SO 2 -), isopropylsulfonyl ((CH 3 ) 2 CHSO 2 -), n-butylsulfonyl (CH 3 CH 2 CH 2 CH 2 SO 2 -), isobutylsulfonyl (CH 3 CH(CH 3 ) 2 SO 2 -), sec-butylsulfonyl (CH 3 CH 2 CH(CH 3 )SO 2 -) or tert-butylsulfonyl ((CH 3 ) 3 CSO 2 -)wait.

[0272] Alkenylcarbonyl: The alkenyl group is attached to the structure via a carbonyl group, for example, vinylcarbonyl, 1-propenylcarbonyl, 2-propenylcarbonyl and different butenylcarbonyl groups.

[0273] Alkynylcarbonyl: The alkynyl group is attached to the structure via the carbonyl group, for example, ethynylcarbonyl, 1-propynylcarbonyl, 2-propynylcarbonyl and the different butynylcarbonyl groups.

[0274] Haloalkylsulfonyl: The hydrogen atoms on the alkyl group of the alkylsulfonyl group may be partially or completely substituted by halogen atoms, for example monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl or perfluoroethylsulfonyl.

[0275] Cycloalkylsulfonyl: The cycloalkyl is attached to the structure via a sulfonyl group, for example, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl or cyclohexylsulfonyl, etc.

[0276] Allyl:

[0277] Propargyl:

[0278] Some of the compounds of general formula I of the present invention are shown in Tables 1 to 118, but the present invention is by no means limited to these compounds.

[0279] When Y is selected from Y 1 When the compound of general formula I is selected from the compound of general formula IA, the compound of general formula IA is shown in Table 1 to Table 28 (for the convenience of description, Q 1 Further defined as -CO-K 1 or -SO 2 -K 2 , K 1 and K 2 The substitution is shown in Tables 1 to 28):

[0280]

[0281] Table 1: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 =X 2 =R 3 =H, K 1 , K 2 The different substituents are shown in Table 1 and the compound numbers are 1.1-1.708.

[0282] Table 1

[0283]

[0284]

[0285]

[0286]

[0287]

[0288]

[0289]

[0290]

[0291]

[0292]

[0293]

[0294]

[0295]

[0296]

[0297]

[0298]

[0299]

[0300]

[0301] Note: “—” in Table 1 means no substitution, the same below.

[0302] Table 2: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 =X 2 =H, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 2.1-2.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0303] Table 3: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 =CH 3 , X 2 =H, R 3 =H, the substituent K 1 , K 2Consistent with Table 1 , the representative compound numbers are 3.1-3.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0304] Table 4: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 =CH 3 , X 2 =H, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 4.1-4.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0305] Table 5: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 =CH 3 , X 2 =CH 3 , R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 5.1-5.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0306] Table 6: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 =CH 3 , X 2 =CH 3 , R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 6.1-6.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0307] Table 7: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 With X 2 Together they form cyclopropyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 7.1-7.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0308] Table 8: In the general formula IA, when R 1 =F,R 2=Cl and X 1 With X 2 Together they form cyclopropyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 8.1-8.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0309] Table 9: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 With X 2 Together they form cyclobutyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 9.1-9.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0310] Table 10: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 With X 2 Together they form cyclobutyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 10.1-10.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0311] Table 11: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 With X 2 Together they form cyclopentyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 11.1-11.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0312] Table 12: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 With X 2 Together they form cyclopentyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 12.1-12.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0313] Table 13: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 With X 2 Together they form cyclohexyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 13.1-13.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0314] Table 14: In the general formula IA, when R 1 =F,R 2 =Cl and X 1 With X 2 Together they form cyclohexyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 14.1-14.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0315] Table 15: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 =X 2 =R 3 =H, K 1 , K 2 The different substituents are shown in Table 1, and the compound numbers are 15.1-15.708, corresponding to 1.1-1.708 in Table 1 respectively.

[0316] Table 16: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 =X 2 =H, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 16.1-16.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0317] Table 17: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 =CH 3 , X 2 =H, R 3 =H, the substituent K 1 , K 2Consistent with Table 1 , the representative compound numbers are 17.1-17.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0318] Table 18: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 =CH 3 , X 2 =H, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 18.1-18.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0319] Table 19: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 =CH 3 , X 2 =CH 3 , R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 19.1-19.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0320] Table 20: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 =CH 3 , X 2 =CH 3 , R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 20.1-20.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0321] Table 21: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 With X 2 Together they form cyclopropyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 21.1-21.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0322] Table 22: In Formula IA, when R 1 =H,R2 =Cl and X 1 With X 2 Together they form cyclopropyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 22.1-22.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0323] Table 23: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 With X 2 Together they form cyclobutyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 23.1-23.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0324] Table 24: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 With X 2 Together they form cyclobutyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 24.1-24.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0325] Table 25: In Formula IA, when R 1 =H,R 2 =Cl and X 1 With X 2 Together they form cyclopentyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 25.1-25.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0326] Table 26: In Formula IA, when R 1 =H,R 2 =Cl and X 1 With X 2 Together they form cyclopentyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 26.1-26.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0327] Table 27: In Formula IA, when R 1 =H,R 2 =Cl and X 1 With X 2 Together they form cyclohexyl, R 3 =H, the substituent K 1 , K 2 Consistent with Table 1 , the representative compound numbers are 27.1-27.708, corresponding to 1.1-1.708 in Table 1 , respectively.

[0328] Table 28: In the general formula IA, when R 1 =H,R 2 =Cl and X 1 With X 2 Together they form cyclohexyl, R 3 =CH 3 When the substituent K 1 , K 2 Consistent with Table 1, the representative compound numbers are 28.1-28.708, corresponding to 1.1-1.708 in Table 1, respectively.

[0329] When Y is selected from Y 2 When the compound of general formula I is selected from the compound of general formula IB, the compound of general formula IB is shown in Table 29 to Table 56 (for the convenience of description, Q 2 Further defined as -CO-K 3 or -SO 2 -K 4 , K 3 and K 4 The substitutions are shown in Tables 29 to 56):

[0330]

[0331] Table 29: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 =X 4 =R 4 =H, K 3 , K 4 The different substituents are shown in Table 29 and the compound numbers are 29.1-29.708.

[0332] Table 29

[0333]

[0334]

[0335]

[0336]

[0337]

[0338]

[0339]

[0340]

[0341]

[0342]

[0343]

[0344]

[0345]

[0346]

[0347]

[0348]

[0349]

[0350] Table 30: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 =X 4 =H, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 30.1-30.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0351] Table 31: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 =CH 3 , X 4 =H, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 31.1-31.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0352] Table 32: In general formula I-B, when R 1 = F, R 2 = Cl and X 3 = CH 3 、X 4 = H、R 4 = CH 3 , the substituents K 3 、K 4 are consistent with Table 29, representing compound numbers 32.1 - 32.708, corresponding to 29.1 - 29.708 of Table 29 in sequence.

[0353] Table 33: In general formula I-B, when R 1 = F, R 2 = Cl and X 3 = CH 3 、X 4 = CH 3 、R 4 = H, the substituents K 3 、K 4 are consistent with Table 29, representing compound numbers 33.1 - 33.708, corresponding to 29.1 - 29.708 of Table 29 in sequence.

[0354] Table 34: In general formula I-B, when R 1 = F, R 2 = Cl and X 3 = CH 3 、X 4 = CH 3 、R 4 = CH 3 , the substituents K 3 、K 4 are consistent with Table 29, representing compound numbers 34.1 - 34.708, corresponding to 29.1 - 29.708 of Table 29 in sequence.

[0355] Table 35: In general formula I-B, when R 1 = F, R 2 = Cl and X 3 and X 4 together form a cyclopropyl group, R 4 = H, the substituents K 3 、K 4 are consistent with Table 29, representing compound numbers 35.1 - 35.708, corresponding to 29.1 - 29.708 of Table 29 in sequence.

[0356] Table 36: In general formula I-B, when R 1 = F, R 2 = Cl and X 3 and X 4Together they form cyclopropyl, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 36.1-36.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0357] Table 37: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 With X 4 Together they form cyclobutyl, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 37.1-37.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0358] Table 38: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 With X 4 Together they form cyclobutyl, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 38.1-38.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0359] Table 39: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 With X 4 Together they form cyclopentyl, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 39.1-39.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0360] Table 40: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 With X 4 Together they form cyclopentyl, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 40.1-40.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0361] Table 41: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 With X 4 Together they form cyclohexyl, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 41.1-41.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0362] Table 42: In the general formula IB, when R 1 =F,R 2 =Cl and X 3 With X 4 Together they form cyclohexyl, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 42.1-42.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0363] Table 43: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 =X 4 =R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 43.1-43.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0364] Table 44: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 =X 4 =H, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 44.1-44.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0365] Table 45: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 =CH 3 , X 4 =H, R 4 =H, the substituent K 3 , K 4Consistent with Table 29, the representative compound numbers are 45.1-45.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0366] Table 46: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 =CH 3 , X 4 =H, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 46.1-46.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0367] Table 47: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 =CH 3 , X 4 =CH 3 , R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 47.1-47.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0368] Table 48: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 =CH 3 , X 4 =CH 3 , R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 48.1-48.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0369] Table 49: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclopropyl, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 49.1-49.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0370] Table 50: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclopropyl, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 50.1-50.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0371] Table 51: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclobutyl, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 51.1-51.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0372] Table 52: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclobutyl, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 52.1-52.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0373] Table 53: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclopentyl, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 53.1-53.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0374] Table 54: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclopentyl, R 4 =CH 3 When the substituent K 3 , K4 Consistent with Table 29, the representative compound numbers are 54.1-54.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0375] Table 55: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclohexyl, R 4 =H, the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 55.1-55.708, corresponding to 29.1-29.708 in Table 29 respectively.

[0376] Table 56: In the general formula IB, when R 1 =H,R 2 =Cl and X 3 With X 4 Together they form cyclohexyl, R 4 =CH 3 When the substituent K 3 , K 4 Consistent with Table 29, the representative compound numbers are 56.1-56.708, corresponding to 29.1-29.708 in Table 29, respectively.

[0377] When Y is selected from Y 3 When the compound of general formula I is selected from the compound of general formula IC, the compound of general formula IC is shown in Table 57 to Table 84 (for the convenience of description, Q 3 Further defined as -CO-K 5 or -SO 2 -K 6 , K 5 and K 6 The substitutions are shown in Tables 57 to 84):

[0378]

[0379] Table 57: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 =X 6 =R 5 =H, K 5 , K 6 See Table 57 for different substituents, and the compound numbers are 57.1-57.708.

[0380] Table 57

[0381]

[0382]

[0383]

[0384]

[0385]

[0386]

[0387]

[0388]

[0389]

[0390]

[0391]

[0392]

[0393]

[0394]

[0395]

[0396]

[0397]

[0398]

[0399] Table 58: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 =X 6 =H, R 5 . =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 58.1-58.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0400] Table 59: In the general IC, when R 1 =F,R 2 =Cl and X 5 =CH 3 , X 6 =H, R 5=H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 59.1-59.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0401] Table 60: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 =CH 3 , X 6 =H, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 60.1-60.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0402] Table 61: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 =CH 3 , X 6 =CH 3 , R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 61.1-61.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0403] Table 62: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 =CH 3 , X 6 =CH 3 , R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 62.1-62.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0404] Table 63: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclopropyl, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 63.1-63.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0405] Table 64: In the general IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclopropyl, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 64.1-64.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0406] Table 65: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclobutyl, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 65.1-65.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0407] Table 66: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclobutyl, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 66.1-66.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0408] Table 67: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclopentyl, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 67.1-67.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0409] Table 68: In the general IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclopentyl, R 5 =CH 3 When the substituent K5 , K 6 Consistent with Table 57, the representative compound numbers are 68.1-68.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0410] Table 69: In the general IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclohexyl, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 69.1-69.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0411] Table 70: In the general formula IC, when R 1 =F,R 2 =Cl and X 5 With X 6 Together they form cyclohexyl, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 70.1-70.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0412] Table 71: In the general IC, when R 1 =H,R 2 =Cl and X 5 =X 6 =R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 71.1-71.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0413] Table 72: In the general IC, when R 1 =H,R 2 =Cl and X 5 =X 6 =H, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 72.1-72.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0414] Table 73: In the general formula IC, when R 1 =H,R 2 =Cl and X5 =CH 3 , X 6 =H, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 73.1-73.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0415] Table 74: In the general formula IC, when R 1 =H,R 2 =Cl and X 5 =CH 3 , X 6 =H, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 74.1-74.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0416] Table 75: In the general IC, when R 1 =H,R 2 =Cl and X 5 =CH 3 , X 6 =CH 3 , R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 75.1-75.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0417] Table 76: In the general formula IC, when R 1 =H,R 2 =Cl and X 5 =CH 3 , X 6 =CH 3 , R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 76.1-76.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0418] Table 77: In the general IC, when R 1 =H,R 2 =Cl and X 5 With X 6 Together they form cyclopropyl, R 5 =H, the substituent K 5 , K6 Consistent with Table 57, the representative compound numbers are 77.1-77.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0419] Table 78: In the general IC, when R 1 =H,R 2 =Cl and X 5 With X 6 Together they form cyclopropyl, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 78.1-78.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0420] Table 79: In the general IC, when R 1 =H,R 2 =Cl and X 5 With X 6 Together they form cyclobutyl, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 79.1-79.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0421] Table 80: In the general IC, when R 1 =H,R 2 =Cl and X 5 With X 6 Together they form cyclobutyl, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 80.1-80.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0422] Table 81: In the general IC, when R 1 =H,R 2 =Cl and X 5 With X 6 Together they form cyclopentyl, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 81.1-81.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0423] Table 82: In the general IC, when R 1 =H,R 2 =Cl and X 5With X 6 Together they form cyclopentyl, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 82.1-82.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0424] Table 83: In the general IC, when R 1 =H,R 2 =Cl and X 5 With X 6 Together they form cyclohexyl, R 5 =H, the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 83.1-83.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0425] Table 84: In the general IC, when R 1 =H,R 2 =Cl and X 5 With X 6 Together they form cyclohexyl, R 5 =CH 3 When the substituent K 5 , K 6 Consistent with Table 57, the representative compound numbers are 84.1-84.708, corresponding to 57.1-57.708 in Table 57 respectively.

[0426] When Y is selected from Y 4 When the compound of general formula I is selected from the compound of general formula ID, the compound of general formula ID is shown in Table 85 to Table 88 (for the convenience of description, Q 4 It is further defined as K 7 、-CO-K 8 or -SO 2 -K 9 , K 7 , K 8 , K 9 The replacement is shown in Table 85 to Table 88):

[0427]

[0428] Table 85: In the general formula ID, when R 1 =F,R 2 =Cl and R 6 =H, K 7 , K 8 , K 9 See Table 85 for different substituents, and the compound numbers are 85.1-85.723.

[0429] Table 85

[0430]

[0431]

[0432]

[0433]

[0434]

[0435]

[0436]

[0437]

[0438]

[0439]

[0440]

[0441]

[0442]

[0443]

[0444]

[0445]

[0446]

[0447]

[0448] Table 86: In the general formula ID, when R 1 =F,R 2 =Cl and R 6 =CH 3 When the substituent K 7 , K 8 , K 9 Consistent with Table 85, the representative compound numbers are 86.1-86.723, corresponding to 85.1-85.723 in Table 85 respectively.

[0449] Table 87: In the general formula ID, when R 1 =H,R 2=Cl and R 6 =H, the substituent K 7 , K 8 , K 9 Consistent with Table 85, the representative compound numbers are 87.1-87.723, corresponding to 85.1-85.723 in Table 85.

[0450] Table 88: In the general formula ID, when R 1 =H,R 2 =Cl and R 6 =CH 3 When the substituent K 7 , K 8 , K 9 Consistent with Table 85, the representative compound numbers are 88.1-88.723, corresponding to 85.1-85.723 in Table 85, respectively.

[0451] When Y is selected from Y 5 When the compound of general formula I is selected from the compound of general formula IE, the compound of general formula IE is shown in Table 89 to Table 92 (for the convenience of description, Q 5 It is further defined as K 10 、-CO-K 11 or -SO 2 -K 12 , K 10 , K 11 , K 12 The replacement is shown in Table 89 to Table 92):

[0452]

[0453] Table 89: In the general formula IE, when R 1 =F,R 2 =Cl and R 7 =H, K 10 , K 11 , K 12 See Table 89 for different substituents, and the compound numbers are 89.1-89.723.

[0454] Table 89

[0455]

[0456]

[0457]

[0458]

[0459]

[0460]

[0461]

[0462]

[0463]

[0464]

[0465]

[0466]

[0467]

[0468]

[0469]

[0470]

[0471]

[0472]

[0473] Table 90: In the general formula IE, when R 1 =F,R 2 =Cl and R 7 =CH 3 When the substituent K 10 , K 11 , K 12 Consistent with Table 89, the representative compound numbers are 90.1-90.723, corresponding to 89.1-89.723 in Table 89, respectively.

[0474] Table 91: In the general formula IE, when R 1 =H,R 2 =Cl and R 7 =H, the substituent K 10 , K 11 , K 12 Consistent with Table 89, the representative compound numbers are 91.1-91.723, corresponding to 89.1-89.723 in Table 89, respectively.

[0475] Table 92: In the general formula IE, when R 1 =H,R 2 =Cl and R 7 =CH 3 When the substituent K 10 , K11 , K 12 Consistent with Table 89, the representative compound numbers are 92.1-92.723, corresponding to 89.1-89.723 in Table 89, respectively.

[0476] When Y is selected from Y 6 When the compound of general formula I is selected from the compound of general formula IF, the compound of general formula IF is shown in Table 93 to Table 100 (for the convenience of description, Q 6 It is further defined as K 13 、-CO-K 14 or -SO 2 -K 15 , K 13 , K 14 , K 15 The replacement is shown in Tables 93 to 100):

[0477]

[0478] Table 93: In the general formula IF, when R 1 =F,R 2 =Cl and R 8 =R 9 =H, K 13 , K 14 , K 15 See Table 93 for different substituents, and the compound numbers are 93.1-93.729.

[0479] Table 93

[0480]

[0481]

[0482]

[0483]

[0484]

[0485]

[0486]

[0487]

[0488]

[0489]

[0490]

[0491]

[0492]

[0493]

[0494]

[0495]

[0496]

[0497]

[0498] Table 94: In General Formula I-F, when R 1 = F, R 2 = Cl and R 8 = H, R 9 = CH 3 , the substituents K 13 , K 14 , K 15 are consistent with Table 93, representing compound numbers 94.1 - 94.729, corresponding to 93.1 - 93.723 of Table 93 in sequence.

[0499] Table 95: In General Formula I-F, when R 1 = F, R 2 = Cl and R 8 = CH 3 , R 9 = H, the substituents K 13 , K 14 , K 15 are consistent with Table 93, representing compound numbers 95.1 - 95.729, corresponding to 93.1 - 93.723 of Table 93 in sequence.

[0500] Table 96: In General Formula I-F, when R 1 = F, R 2 = Cl and R 8 = CH 3 , R 9 = CH 3 , the substituents K 13 , K 14 , K 15 are consistent with Table 93, representing compound numbers 96.1 - 96.729, corresponding to 93.1 - 93.723 of Table 93 in sequence.

[0501] Table 97: In General Formula I-F, when R 1 = H, R 2 = Cl and R8 =H, R 9 =H, the substituent K 13 , K 14 , K 15 Consistent with Table 93, the representative compound numbers are 97.1-97.729, corresponding to 93.1-93.723 in Table 93 respectively.

[0502] Table 98: In the general formula IF, when R 1 =H,R 2 =Cl and R 8 =H, R 9 =CH 3 When the substituent K 13 , K 14 , K 15 Consistent with Table 93, the representative compound numbers are 98.1-98.729, corresponding to 93.1-93.723 in Table 93, respectively.

[0503] Table 99: In the general formula IF, when R 1 =H,R 2 =Cl and R 8 =CH 3 , R 9 =H, the substituent K 13 , K 14 , K 15 Consistent with Table 93, the representative compound numbers are 99.1-99.729, corresponding to 93.1-93.723 in Table 93 respectively.

[0504] Table 100: In the general formula IF, when R 1 =H,R 2 =Cl and R 8 =CH 3 , R 9 =CH 3 When the substituent K 13 , K 14 , K 15 Consistent with Table 93, the representative compound numbers are 100.1-100.729, corresponding to 93.1-93.723 in Table 93 respectively.

[0505] When Y is selected from Y 7 When the compound of general formula I is selected from the compound of general formula IG, the compound of general formula IG is shown in Table 101 to Table 104:

[0506]

[0507] Table 101: In the general formula IG, when R 1 =F,R 2 =Cl and R 10=H, n is selected from 0, 1 or 2, representing compound numbers 101.1-101.3.

[0508] Table 101

[0509] Compound No. n 101.1 0 101.2 1 101.3 2 .

[0510] Table 102: In the general formula IG, when R 1 =F,R 2 =Cl and R 10 =CH 3 When n is selected from 0, 1 or 2, the representative compound number is 102.1-102.3, which corresponds to 101.1-101.3 of Table 101 respectively.

[0511] Table 103: In the general formula IG, when R 1 =H,R 2 =Cl and R 10 When =H, n is selected from 0, 1 or 2, representing compound numbers 103.1-103.3, corresponding to 101.1-101.3 in Table 101 respectively.

[0512] Table 104: In the general formula IG, when R 1 =H,R 2 =Cl and R 10 =CH 3 When n is selected from 0, 1 or 2, the representative compound number is 104.1-104.3, which corresponds to 101.1-101.3 in Table 101.

[0513] When Y is selected from Y 8 When the compound of general formula I is selected from the compound of general formula IH, the compound of general formula IH is shown in Table 105 to Table 108 (for the convenience of description, Q 7 It is further defined as K 16 、-CO-K 17 or -SO 2 -K 18 , K 16 , K 17 , K 18 The substitutions are shown in Tables 105 to 108):

[0514]

[0515] Table 105: In the general formula IH, when R 1 =F,R 2 =Cl and R 11 =H, K 16 , K 17 , K 18See Table 105 for different substituents, and the compound numbers are 105.1-105.723.

[0516] Table 105

[0517]

[0518]

[0519]

[0520]

[0521]

[0522]

[0523]

[0524]

[0525]

[0526]

[0527]

[0528]

[0529]

[0530]

[0531]

[0532]

[0533]

[0534]

[0535]

[0536] Table 106: In the general formula IH, when R 1 =F,R 2 =Cl and R 6 =CH 3 When the substituent K 16 , K 17 , K 18Consistent with Table 105, the representative compound numbers are 106.1-106.723, corresponding to 105.1-105.723 in Table 105, respectively.

[0537] Table 107: In the general formula IH, when R 1 =H,R 2 =Cl and R 6 =H, the substituent K 16 , K 17 , K 18 Consistent with Table 105, the representative compound numbers are 107.1-107.723, corresponding to 105.1-105.723 in Table 105, respectively.

[0538] Table 108: In the general formula IH, when R 1 =H,R 2 =Cl and R 6 =CH 3 When the substituent K 16 , K 17 , K 18 Consistent with Table 105, the representative compound numbers are 108.1-108.723, corresponding to 105.1-105.723 in Table 105, respectively.

[0539] When Y is selected from Y 9 When the compound of general formula I is selected from the compound of general formula IJ, the compound of general formula IJ is shown in Table 109 to Table 110 (for the convenience of description, Q 8 It is further defined as K 19 、-CO-K 20 or -SO 2 -K 21 , K 19 , K 20 , K 21 The replacement is shown in Tables 109 to 110):

[0540]

[0541] Table 109: In general formula IJ, when R 1 =F,R 2 =Cl, K 19 , K 20 , K 21 See Table 109 for different substituents, and the compound numbers are 109.1-109.723.

[0542] Table 109

[0543]

[0544]

[0545]

[0546]

[0547]

[0548]

[0549]

[0550]

[0551]

[0552]

[0553]

[0554]

[0555]

[0556]

[0557]

[0558]

[0559]

[0560]

[0561] Table 110: In general formula IJ, when R 1 =H,R 2 =Cl, substituent K 19 , K 20 , K 21 Consistent with Table 109, the representative compound numbers are 110.1-110.723, corresponding to 109.1-109.723 in Table 109, respectively.

[0562] When Y is selected from Y 10 When the compound of general formula I is selected from the compound of general formula IL, the compound of general formula IL is shown in Table 111 to Table 114 (for the convenience of description, Q 9 It is further defined as K 22 、-CO-K 23 or -SO 2 -K 24 , K 22 , K 23 , K24 The replacement is shown in Tables 111 to 114):

[0563]

[0564] Table 111: In the general formula IL, when R 1 =F,R 2 =Cl and R 12 =H, K 22 , K 23 , K 24 See Table 111 for different substituents, and the compound numbers are 111.1-111.723.

[0565] Table 111

[0566]

[0567]

[0568]

[0569]

[0570]

[0571]

[0572]

[0573]

[0574]

[0575]

[0576]

[0577]

[0578]

[0579]

[0580]

[0581]

[0582]

[0583]

[0584] Table 112: In the general formula IL, when R 1 =F,R 2 =Cl and R 12 =CH 3 When the substituent K 22 , K 23 , K 24 Consistent with Table 111, the representative compound numbers are 112.1-112.723, corresponding to 111.1-111.723 in Table 111, respectively.

[0585] Table 113: In the general formula IL, when R 1 =H,R 2 =Cl and R 12 =H, the substituent K 22 , K 23 , K 24 Consistent with Table 111, the representative compound numbers are 113.1-113.723, corresponding to 111.1-111.723 in Table 111, respectively.

[0586] Table 114: In the general formula IL, when R 1 =H,R 2 =Cl and R 12 =CH 3 When the substituent K 22 , K 23 , K 24 Consistent with Table 111, the representative compound numbers are 114.1-114.723, corresponding to 111.1-111.723 in Table 112, respectively.

[0587] When Y is selected from Y 11 When the compound of general formula I is selected from the compound of general formula IM, the compound of general formula IM is shown in Table 115 to Table 118 (for the convenience of description, Q 10 It is further defined as K 25 、-CO-K 26 or -SO 2 -K 27 , K 25 , K 26 , K 27 The substitutions are shown in Tables 115 to 118):

[0588]

[0589] Table 115: In the general formula IM, when R 1 =F,R 2 =Cl and R 13 =H, K 25 , K 26 , K 27See Table 115 for different substituents, and the compound numbers are 115.1-115.723.

[0590] Table 115

[0591]

[0592]

[0593]

[0594]

[0595]

[0596]

[0597]

[0598]

[0599]

[0600]

[0601]

[0602]

[0603]

[0604]

[0605]

[0606]

[0607]

[0608]

[0609]

[0610] Table 116: In the general formula IL, when R 1 =F,R 2 =Cl and R 12 =CH 3 When the substituent K 25 , K 26 , K 27Consistent with Table 115, the representative compound numbers are 116.1-116.723, corresponding to 115.1-115.723 in Table 115, respectively.

[0611] Table 117: In the general formula IL, when R 1 =H,R 2 =Cl and R 12 =H, the substituent K 25 , K 26 , K 27 Consistent with Table 115, the representative compound numbers are 117.1-117.723, corresponding to 115.1-115.723 in Table 115, respectively.

[0612] Table 118: In the general formula IL, when R 1 =H,R 2 =Cl and R 12 =CH 3 When the substituent K 25 , K 26 , K 27 Consistent with Table 115, the representative compound numbers are 118.1-118.723, corresponding to 115.1-115.723 in Table 115, respectively.

[0613] When the compound of general formula I of the present invention is a compound of general formula IA, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IA includes the compound of general formula IA-1, the compound of general formula IA-2 and the compound of general formula IA-3, wherein the groups are defined as above unless otherwise specified):

[0614]

[0615] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0616] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0617] The compound of formula M-2 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house according to conventional methods.

[0618] When the compound of general formula I of the present invention is a compound of general formula IB, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IB includes the compound of general formula IB-1, the compound of general formula IB-2 and the compound of general formula IB-3, wherein the groups are defined as above unless otherwise specified):

[0619]

[0620] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0621] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0622] The compound of formula M-4 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house according to conventional methods.

[0623] When the compound of general formula I of the present invention is a compound of general formula IC, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IC includes a compound of general formula IC-1, a compound of general formula IC-2 and a compound of general formula IC-3, wherein the groups are defined as above unless otherwise specified):

[0624]

[0625] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0626] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0627] The compound of formula M-6 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house according to conventional methods.

[0628] When the compound of general formula I of the present invention is a compound of general formula IA, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IA includes the compound of general formula IA-1, the compound of general formula IA-2 and the compound of general formula IA-3, wherein the groups are defined as above unless otherwise specified)

[0629]

[0630] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0631] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0632] The compound of formula M-8 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house according to conventional methods.

[0633] When the compound of general formula I of the present invention is a compound of general formula IE, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IE includes a compound of general formula IE-1, a compound of general formula IE-2 and a compound of general formula IE-3, wherein the groups are defined as above unless otherwise specified):

[0634]

[0635] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0636] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0637] The compound of formula M-10 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house according to conventional methods.

[0638] When the compound of general formula I of the present invention is a compound of general formula IF, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IF includes the compound of general formula IF-1 and the compound of general formula IF-2, wherein the groups are defined as above unless otherwise specified):

[0639]

[0640] The above reaction is carried out in a suitable solvent. The suitable solvent can be the same or different and can be alcohols (such as methanol, ethanol, etc.), aromatic hydrocarbons (such as benzene, toluene, xylene, etc.), ketones (such as acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (such as dichloromethane, chloroform, carbon tetrachloride, etc.), esters (such as methyl acetate, ethyl acetate, etc.), ethers (such as tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (such as water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction can be carried out in the presence or absence of a base. When the reaction is carried out in the presence of a base, the reaction can be accelerated. The base can be selected from alkali metal hydrides such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides such as sodium hydroxide or potassium hydroxide; alkali metal carbonates such as sodium carbonate or potassium carbonate; organic bases such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point temperature of the suitable solvent selected in the reaction, usually 0 - 100°C. The reaction time is 30 minutes to 20 hours, usually 1 - 10 hours.

[0641] The compound of general formula M-1 can be prepared by a known method (such as US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0642] The compound of general formula M-12 and other conventional raw materials and reagents are usually commercially available or can be prepared by conventional methods.

[0643] When the compound of general formula I of the present invention is a compound of general formula I-G, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula I-G includes the compound of general formula I-G-1, the compound of general formula I-G-2 and the compound of general formula I-G-3, and the definitions of each group in the formula are the same as above unless otherwise specified):

[0644]

[0645] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0646] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0647] The compound of formula M-13 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house by conventional methods.

[0648] When the compound of general formula I of the present invention is a compound of general formula IH, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IH includes the compound of general formula IH-1, the compound of general formula IH-2 and the compound of general formula IH-3, wherein the groups are defined as above unless otherwise specified):

[0649]

[0650] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0651] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0652] The compound of formula M-14 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house by conventional methods.

[0653] When the compound of general formula I of the present invention is a compound of general formula IJ, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IJ includes the compound of general formula IJ-1, the compound of general formula IJ-2 and the compound of IJ-3, wherein the groups are defined as above unless otherwise specified):

[0654]

[0655] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0656] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0657] The compound of formula M-15 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house by conventional methods.

[0658] When the compound of general formula I of the present invention is a compound of general formula IL, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula IL includes a compound of general formula IL-1, a compound of general formula IL-2 and a compound of general formula IL-3, wherein the groups are defined as above unless otherwise specified):

[0659]

[0660] The above reaction is carried out in a suitable solvent. The suitable solvent can be the same or different and can be alcohols (such as methanol, ethanol, etc.), aromatic hydrocarbons (such as benzene, toluene, xylene, etc.), ketones (such as acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (such as dichloromethane, chloroform, carbon tetrachloride, etc.), esters (such as methyl acetate, ethyl acetate, etc.), ethers (such as tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (such as water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction can be carried out in the presence or absence of a base. When the reaction is carried out in the presence of a base, the reaction can be accelerated. The base can be selected from alkali metal hydrides such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides such as sodium hydroxide or potassium hydroxide; alkali metal carbonates such as sodium carbonate or potassium carbonate; organic bases such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point temperature of the suitable solvent selected in the reaction, usually 0 - 100°C. The reaction time is 30 minutes to 20 hours, usually 1 - 10 hours.

[0661] The compound of general formula M-1 can be prepared by a known method (such as US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0662] The compound of general formula M-17 and other conventional raw materials and reagents are usually commercially available or can be prepared by conventional methods.

[0663] When the compound of general formula I of the present invention is a compound of general formula I-M, the compound of general formula I of the present invention can be prepared according to the following route (the compound of general formula I-M includes the compound of general formula I-M-1, the compound of general formula I-M-2 and the compound of general formula I-M-3, and the definitions of each group in the formula are the same as above unless otherwise specified):

[0664]

[0665] The above reaction is carried out in a suitable solvent, which may be the same or different alcohols (e.g., methanol, ethanol, etc.), aromatic hydrocarbons (e.g., benzene, toluene, xylene, etc.), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.), halogenated hydrocarbons (e.g., dichloromethane, chloroform, carbon tetrachloride, etc.), esters (e.g., methyl acetate, ethyl acetate, etc.), ethers (e.g., tetrahydrofuran, dioxane, diethyl ether, 1,2-dimethoxyethane, etc.), polar solvents (e.g., water, acetonitrile, dioxane, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, etc.) or a mixed solvent of the above solvents. The reaction may be carried out in the presence of a base or in the absence of a base. When the reaction is carried out in the presence of a base, the reaction may be accelerated. The base can be selected from alkali metal hydrides, such as sodium hydride, lithium hydride or sodium amide, etc.; alkali metal hydroxides, such as sodium hydroxide or potassium hydroxide; alkali metal carbonates, such as sodium carbonate or potassium carbonate; organic bases, such as pyridine, 4-dimethylaminopyridine, triethylamine, N-methylpyrrole or diisopropylethylamine, etc. The reaction temperature can be between -10°C and the boiling point of the appropriate solvent selected in the reaction, usually 0 to 100°C. The reaction time is 30 minutes to 20 hours, usually 1 to 10 hours.

[0666] The compound of formula M-1 can be prepared according to a known method (eg, US5169430 A, WO2003029226 A1, WO2018128390A1 or WO2019121547A1).

[0667] The compound of formula M-19 and other conventional raw materials and reagents are usually commercially available or can be prepared in-house according to conventional methods.

[0668] The compound of the general formula I of the present invention can effectively control weeds such as barnyard grass, zinnia, foxtail grass, velvetleaf, etc., and a good effect can be obtained at a low dosage. It has certain safety for wheat, corn, and rice, and can be used as a herbicide in agriculture. Therefore, the present invention also includes the use of the compound of the general formula I for controlling weeds.

[0669] The present invention also provides a herbicidal composition, wherein the composition uses the compound of general formula I as an active component, and the weight percentage of the active component in the composition is 0.1-99%. Therefore, the present invention also includes the use of the composition for controlling weeds.

[0670] The composition of the present invention can be prepared into corresponding dosage forms by methods known to those skilled in the art. The active ingredient can contain a single compound of the present invention or a mixture of several compounds.

[0671] The carrier system in the composition of the present invention is a material that meets the following conditions: it is convenient to apply to the site to be treated, such as plants, seeds or soil after being formulated with the active ingredient; or it is convenient for storage, transportation or handling. The carrier can be solid or liquid, including a substance that is usually gaseous but has been compressed into a liquid. The carriers commonly used in the preparation of herbicidal compositions can be used.

[0672] Suitable solid carriers include natural and synthetic clays and silicates (e.g., diatomaceous earth, talc, attapulgite, aluminum silicate (kaolin), montmorillonite and mica), calcium carbonate, calcium sulfate, ammonium sulfate, synthetic silica, synthetic calcium silicate, synthetic aluminum silicate, natural resins, synthetic resins (natural resins, synthetic resins such as coumarone resins, polyvinyl chloride and styrene polymers and copolymers), solid polychlorinated phenols, asphalt, or waxes (e.g., beeswax, paraffin).

[0673] Suitable liquid carriers include water, alcohols (such as isopropanol and ethanol), ketones (such as acetone, methyl ethyl ketone, methyl isopropyl ketone, cyclohexyl ketone), ethers, aromatic hydrocarbons (such as benzene, toluene, xylene), petroleum fractions (such as kerosene and mineral oil), chlorinated hydrocarbons (such as carbon tetrachloride, perchloroethylene and trichloroethylene) or a mixture of several thereof.

[0674] The composition is usually prepared in the form of a concentrate and used for transportation, which is diluted by the user before application. The presence of a small amount of a surfactant carrier helps the dilution process. Thus, at least one carrier in the composition according to the present invention is preferably a surfactant. For example, the composition may contain at least two carriers, at least one of which is a surfactant.

[0675] The surfactant may be an emulsifier, a dispersant or a wetting agent; it may be a nonionic or an ionic surfactant. Examples of suitable surfactants include sodium or calcium salts of polyacrylic acid and lignin sulfonic acid; condensates of fatty acids or fatty amines or amides containing at least 12 carbon atoms in the molecule with ethylene oxide and / or propylene oxide. Glycol, sorbitol, sucrose or pentaerythritol fatty acid esters and condensates of these esters with ethylene oxide and / or propylene oxide; condensates of fatty alcohols or alkylphenols such as p-octylphenol or p-octylcresol with ethylene oxide and / or propylene oxide; sulfates and sulfonates of these condensation products; alkali metal or alkaline earth metal salts of sulfuric acid or sulfonic acid esters containing at least 10 carbon atoms in the molecule, preferably sodium salts, for example sodium laurate sulfate, sodium secondary alkyl sulfate, sodium sulfonated castor oil, sodium alkyl aryl sulfonate, such as sodium dodecylbenzenesulfonate.

[0676] Examples of compositions of the invention are wettable powders, dusts, granules, aqueous solutions, emulsifiable concentrates, emulsions, aerosols and mists. Wettable powders usually contain 25-75% by weight of active ingredient and usually contain, in addition to a solid inert carrier, 3-10% by weight of a dispersant and, if necessary, 0-10% by weight of a stabilizer and / or other additives such as a penetrant or adhesive. Dusts can usually be powder concentrates having a composition similar to that of wettable powders but without a dispersant, which are further diluted with a solid carrier to obtain a composition usually containing 0.5-10% by weight of the active ingredient. Granules are usually prepared to have a size of 10 to 100 mesh (1.676-0.152 mm) and can be prepared by agglomeration or injection techniques. Granules usually contain 0.5-75% by weight of active ingredient and 0-10% by weight of additives (additives such as stabilizers, surfactants or slow-release modifiers). Emulsifiable concentrates usually contain, in addition to the solvent, a cosolvent when necessary, 1-50% W / V active ingredient, 2-20% W / V emulsifier and 0-20% W / V other additives (additives such as stabilizers, penetrants or corrosion inhibitors). Suspension concentrates usually contain 10-75% by weight of active ingredient, 0.5-15% by weight of dispersant, 0.1-10% by weight of other additives (additives such as defoamers, corrosion inhibitors, stabilizers, penetrants and adhesives).

[0677] Aqueous dispersions and emulsions, for example compositions obtained by diluting a wettable powder or a concentrate according to the invention with water, also lie within the scope of the invention. The emulsions may be of either the water-in-oil or the oil-in-water type.

[0678] By adding one or more other herbicides to the composition, it can have a broader spectrum of activity than the single compound of formula I. In addition, other herbicides can have a synergistic effect on the herbicidal activity of the compound of formula I, and the compound of formula I can also be mixed with other herbicides. The content of the active ingredient in the mixture varies greatly, and the content of the active ingredient in the mixture is generally 1%-95%, and the more suitable content is 5%-60%.

[0679] The composition using the compound of general formula I of the present invention as an active ingredient can effectively control weeds. The compound can be used as a herbicide to effectively control weeds such as barnyard grass, velvetleaf, foxtail grass, and zinnia, and has certain safety to wheat, corn, and rice, and can be used as a herbicide in agriculture.

[0680] The present invention has no particular limitation on the method for preparing the pesticide herbicide, and those skilled in the art can adopt conventional preparation methods in the field of pesticides to prepare the corresponding reagents.

[0681] The pesticide herbicide of the present invention includes, but is not limited to, application to crops by methods such as spraying.

[0682] It should be understood that various changes and modifications can be made within the scope of the present invention as defined by the claims. DETAILED DESCRIPTION

[0683] The following specific examples are used to further illustrate the present invention, but the present invention is by no means limited to these examples. (Unless otherwise noted, all raw materials used are commercially available)

[0684] Synthesis Example

[0685] According to the synthetic route described above, different raw material compounds can be used to prepare the compounds represented by the general formula I of the present invention, which are further described as follows:

[0686] Example 1: Preparation of compounds 1.20 and 1.43

[0687]

[0688] 1) Preparation of tert-butyl (2-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)ethyl)carbamate (Compound 1.20)

[0689] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 4.57 g (28.5 mmol) of N-tert-butyloxycarbonyl-1,2-ethylenediamine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried over anhydrous magnesium sulfate, desolventized and concentrated to obtain 6.72 g of white solid, which was compound 1.20. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.14(t,1H),8.00(d,1H),6.83(t,1H),6.61(s,1H),3.42(s, 3H),3.02(q,2H),2.89(q,2H),1.37(s,9H).LC-MS(m / z,ESI):567.08(M+Na) + .

[0690] 2) Preparation of N-(2-aminoethyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride

[0691] 6.72 g of tert-butyl (2-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)ethyl)carbamate (Compound 1.20) was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 5.91 g of light yellow colloidal solid was obtained.

[0692] 3) Preparation of compound 1.43

[0693] 0.31 g (0.65 mmol) of N-(2-aminoethyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.12 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 55 mg (0.72 mmol) of benzoyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.21 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.51(t,1H),8.28(t,1H),8.21(d,1H),7.97(d,1H),7.85-7.80(m,2H),7.55-7.50(m,1H),7.48 -7.43(m,2H),6.61(s,1H),3.42(s,3H),3.37(q,2H),3.07(q,2H).LC-MS(m / z,ESI):549.06(M+H) + .

[0694] With reference to the preparation of compound 1.43 in Example 1, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[0695] Compound 1.1:

[0696]

[0697] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.18(d,1H),8.16(t,1H),8.00(d,1H),7.90(t,1H),6.61(s,1H),3.42(s,3H ),3.11(q,2H),2.94-2.87(m,2H),1.78(s,3H).LC-MS(m / z,ESI):486.96(M+H) + .

[0698] Compound 1.2:

[0699]

[0700] White solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.15(s,1H),8.00(d,1H),7.81(t,1H),6.61(s,1H),3.42(s,3H),3.1 3(q,2H),2.95-2.85(m,2H),2.05(q,2H),0.97(t,3H).LC-MS(m / z,ESI):500.98(M+H) + .

[0701] Compound 1.3:

[0702]

[0703] White solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.15(t,1H),8.00(d,1H),7.83(t,1H),6.61(s,1H),3.42(s,3H),3.13(q,2H), 2.94-2.86(m,2H),2.01(t,2H),1.53-1.44(m,2H),0.83(t,3H).LC-MS(m / z,ESI):515.02(M+H) + .

[0704] Compound 1.4:

[0705]

[0706] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.19(d,1H),8.17-8.13(m,1H),8.00(d,1H),7.79(t,1H),6.61(s,1H),3.42(s,3H),3 .13(q,2H),2.90(q,2H),2.35-2.26(m,1H),0.98(d,6H).LC-MS(m / z,ESI):515.00(M+H) + .

[0707] Compound 1.5:

[0708]

[0709] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.14(d,1H),8.00(d,1H),7.84(t,1H),6.61(s,1H),3.42(s,3H),3.13(q,2H),2.94-2.8 5(m,2H),2.04(t,2H),1.50-1.41(m,2H),1.28-1.20(m,2H),0.85(t,3H).LC-MS(m / z,ESI):529.07(M+H) + .

[0710] Compound 1.8:

[0711]

[0712] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.17-8.12(m,1H),8.01(d,1H),7.50(t,1H),6.61(s,1H),3.42 (s,3H),3.15(q,2H),2.90(q,2H),1.07(s,9H).LC-MS(m / z,ESI):529.00(M+H) + .

[0713] Compound 1.9:

[0714]

[0715] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.20-8.15(m,2H),8.12(t,1H),7.99(d,1H),6.61(s,1H),3.42(s,3H),3.16-3.12(m,2H ),2.95-2.85(m,2H),1.52-1.43(m,1H),0.68-0.57(m,4H).LC-MS(m / z,ESI):513.07(M+H) + .

[0716] Compound 1.10:

[0717]

[0718] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.15(t,1H),8.00(d,1H),7.70(t,1H),6.61(s,1H),3.42(s,3H),3.13(q,2H),2.98-2.85(m,3 H),2.14-2.05(m,2H),2.03-1.95(m,2H),1.91-1.81(m,1H),1.77-1.66(m,1H).LC-MS(m / z,ESI):527.01(M+H) + .

[0719] Compound 1.11:

[0720]

[0721] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.16(d,1H),8.12(t,1H),7.97(d,1H),7.78(t,1H),6.58(s,1H),3.39(s,3H),3.10(q,2H),2.91-2.83(m,2 H),2.49-2.43(m,1H),1.73-1.64(m,2H),1.62-1.51(m,4H),1.50-1.40(m,2H).LC-MS(m / z,ESI):541.05(M+H) + .

[0722] Compound 1.13:

[0723]

[0724] White solid. 1 H NMR (600 MHz, DMSO-d6 )δ8.22-8.15(m,2H),8.01(d,1H),7.16(t,1H),6.61(s,1H),3.51(s,3H),3 .43(s,3H),3.08(q,2H),2.95-2.88(m,2H).LC-MS(m / z,ESI):503.19(M+H) + .

[0725] Compound 1.14:

[0726]

[0727] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.21-8.14(m,2H),8.01(d,1H),7.11(t,1H),6.61(s,1H),3.97(q,2H),3.43 (s,3H),3.07(q,2H),2.91(q,2H),1.14(t,3H).LC-MS(m / z,ESI):517.06(M+H) + .

[0728] Compound 1.21:

[0729]

[0730] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.25-8.14(m,3H),8.00(d,1H),6.61(s,1H),6.21-6.14(m,1H),6.11-6.03(m,1H) ,5.59(dd,1H),3.42(s,3H),3.23(q,2H),2.95(q,2H).LC-MS(m / z,ESI):499.00(M+H) + .

[0731] Compound 1.24:

[0732]

[0733] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.76(t,1H),8.23(t,1H),8.18(d,1H),8.00(d,1H),6.61(s,1H),4.15(s ,1H),3.42(s,3H),3.17(q,2H),2.94(q,2H).LC-MS(m / z,ESI):497.00(M+H) + .

[0734] Compound 1.28:

[0735]

[0736] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.27(t,1H),8.23-8.16(m,2H),8.01(d,1H),6.61(s,1H),4.04(s,2H),3.42(s,3H),3.20(q,2H),2.95(q,2H).LC-MS(m / z,ESI):542.98(M+Na) + .

[0737] Compound 1.32:

[0738]

[0739] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.22-8.16(m,2H),8.01(d,1H),7.83(t,1H),6.61(s,1H),3.77(s,2H),3.42 (s,3H),3.30(s,3H),3.21(q,2H),2.95(q,2H).LC-MS(m / z,ESI):517.00(M+H) + .

[0740] Compound 1.37:

[0741]

[0742] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.21-8.15(m,3H),8.00(d,1H),6.61(s,1H),3.61(s,3H),3.42(s,3H),3 .21(s,2H),3.16(q,2H),2.95-2.89(m,2H).LC-MS(m / z,ESI):544.94(M+H)+ .

[0743] Compound 1.40:

[0744]

[0745] White solid. 1 H NMR (600 MHz, DMSO-d 6 ) δ 8.99 (d, 1H), 8.75 - 8.68 (m, 2H), 8.30 (t, 1H), 8.20 (d, 1H), 8.16 - 8.13 (m, 1H), 7.97 (d, 1H), 7.53 - 7.47 (m, 1H), 6.60 (s, 1H), 3.41 (s, 3H), 3.38 (q, 2H), 3.08 (q, 2H). LC-MS (m / z, ESI): 548.12 (M-H) - .

[0746] Compound 1.46:

[0747]

[0748] White solid. 1 H NMR (600 MHz, DMSO-d 6 ) δ 8.53 (t, 1H), 8.27 (t, 1H), 8.20 (d, 1H), 7.96 (d, 1H), 7.92 - 7.86 (m, 2H), 7.29 (t, 2H), 6.60 (s, 1H), 3.41 (s, 3H), 3.36 (q, 2H), 3.06 (q, 2H). LC-MS (m / z, ESI): 567.05 (M+H) + .

[0749] Compound 1.355:

[0750]

[0751] White solid. 1 H NMR (600 MHz, DMSO-d 6 ) δ 8.25 - 8.19 (m, 2H), 8.01 (d, 1H), 7.12 (t, 1H), 6.60 (s, 1H), 3.41 (s, 3H), 3.05 - 2.95 (m, 4H), 2.89 (s, 3H). LC-MS (m / z, ESI): 523.10 (M+H) + .

[0752] Compound 1.363:

[0753]

[0754] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.26-8.20(m,2H),8.03(d,1H),7.19(t,1H),6.62(s,1H),3.42(s,3H),3.10-3.05(m,2H ),3.03-2.96(m,2H),0.95-0.90(m,2H),0.88-0.85(m,2H).LC-MS(m / z,ESI):548.90(M+H) + .

[0755] Compound 1.379:

[0756]

[0757] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ9.60(s,1H),8.34(t,1H),8.21(d,1H),8.03(d,1H),6.62(s,1H),3.43(s,3H),3.24(t,2H),3.04-2.99(m,2H).LC-MS(m / z,ESI):598.84(M+Na) + .

[0758] Compound 1.397:

[0759]

[0760] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.18-8.14(m,2H),7.97(d,1H),7.77-7.74(m,3H),7.66-7.62(m,1H),7.61-7.57(m,2H),6 .61(s,1H),3.42(s,3H),2.92-2.86(m,2H),2.84-2.78(m,2H).LC-MS(m / z,ESI):584.93(M+H) + .

[0761] Compound 1.403:

[0762]

[0763] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.20-8.11(m,2H),7.97(d,1H),7.67-7.60(m,3H),7.38(d,2H),6.60(s,1H),3.42(s ,3H),2.92-2.86(m,2H),2.81-2.75(m,2H),2.38(s,3H).LC-MS(m / z,ESI):599.06(M+H) + .

[0764] Example 2: Preparation of Compound 2.2

[0765]

[0766] Take 0.27 g (0.54 mmol) of N-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenylsulfonamide)ethyl propionamide (Compound 1.2) and place it in a 25 ml round-bottom flask, add 10 ml of N,N-dimethylformamide to dissolve and dilute. After it is completely dissolved, add 0.30 g (2.17 mmol) of potassium carbonate to the above reaction flask, and then add 0.31 g (2.18 mmol) of iodomethane dropwise. Stir at room temperature and react for 1 hour. TLC monitoring shows that the reaction is complete. The reaction solution is extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.15 g of white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.16(d,1H),8.02(d,1H),7.88(t,1H),6.61(s,1H),3.42(s,3H),3.30-3.21 (m,4H),2.84(s,3H),2.07(q,2H),0.99(t,3H).LC-MS(m / z,ESI):515.23(M+H) + .

[0767] With reference to the preparation of compound 2.2 in Example 2, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[0768] Compound 2.4:

[0769]

[0770] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.16(d,1H),8.02(d,1H),7.86(t,1H),6.62(s,1H),3.42(s,3H),3.30-3.22(m ,4H),2.84(s,3H),2.37-2.28(m,1H),1.00(d,6H).LC-MS(m / z,ESI):529.24(M+H) + .

[0771] Example 3: Preparation of Compound 3.2 and Compound 3.20

[0772]

[0773] 1) Preparation of tert-butyl (2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)propyl)carbamate (Compound 3.20)

[0774] 1.00 g (2.38 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 25 ml single-mouth round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 0.48 g (4.76 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 0.46 g (2.64 mmol) of tert-butyl (2-aminopropyl) carbamate. Stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extract with water and dichloromethane, retain the organic phase, add anhydrous magnesium sulfate to dry, desolventize and concentrate, and obtain 0.68 g of white solid. LC-MS (m / z, ESI): 559.13 (M+H) + ..

[0775] 2) Preparation of N-(1-amino-2-ylpropyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-benzenesulfonamide hydrochloride

[0776] 0.68 g of tert-butyl (2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)propyl)carbamate (Compound 3.20) was placed in a 100 ml single-mouth round-bottom flask, and 10 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 0.46 g of a light yellow colloidal solid was obtained.

[0777] 3) Preparation of compound 3.2

[0778] 0.20 g (0.40 mmol) of N-(1-amino-2-ylpropyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-benzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.08 g (0.79 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 4 mg (0.43 mmol) of propionyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.13 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.22-8.19(m,1H),8.03(d,1H),7.99(d,1H),7.81-7.74(m,1H),6.59(d,1H),3.41(s,3H),3.31-3.25 (m,1H),3.12-2.98(m,2H),2.04(q,2H),0.99-0.94(m,3H),0.89(t,3H).LC-MS(m / z,ESI):515.23(M+H) + .

[0779] With reference to the preparation of compound 3.2 in Example 3, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[0780] Compound 3.4:

[0781]

[0782] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.22-8.19(m,1H),8.06-8.02(m,1H),7.99(d,1H),7.80-7.72(m,1H),6.59(d,1H),3.41(s,3H),3.32-3.28 (m,1H),3.13-2.98(m,2H),2.37-2.27(m,1H),1.00-0.95(m,6H),0.88(t,3H).LC-MS(m / z,ESI):529.25(M+H) + .

[0783] Example 4: Preparation of Compound 4.2

[0784]

[0785] Take 0.13 g (0.25 mmol) of N-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)phenylsulfonamido)ethyl propanamide (Compound 3.2) and place it in a 25 mL round-bottom flask. Add 10 mL of N,N-dimethylformamide to dissolve and dilute it. After it is completely dissolved, add 0.07 g (0.50 mmol) of potassium carbonate to the above reaction flask, and then dropwise add 0.04 g (0.27 mmol) of methyl iodide. Stir at room temperature for 1 hour. Monitor the reaction by TLC until it is complete. Extract the reaction solution with water and dichloromethane, remove the solvent by concentration, and perform column chromatography separation and purification. Then, 0.08 g of white solid is obtained. 1 H NMR(600MHz,DMSO-d 6 )δ8.22(dd,1H),8.01(d,1H),7.79 - 7.72(m,1H),6.60(s,1H),4.02 - 3.92(m,1H),3.42(d,3H),3.15 - 3.06(m,2H),2.73(d,3H),2.04(q,2H),1.01 - 0.93(m,6H).LC-MS(m / z,ESI):529.25(M + H) + 。

[0786] Referring to the preparation of Compound 4.2 in Example 4, the physical and chemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[0787] Compound 4.4:

[0788]

[0789] White solid. 1 H NMR(600MHz,DMSO-d 6 )δ8.25 - 8.21(m,1H),8.01(d,1H),7.78 - 7.71(m,1H),6.60(s,1H),4.04 - 3.94(m,1H),3.42(d,3H),3.15 - 3.05(m,2H),2.73(d,3H),2.36 - 2.28(m,1H),0.99(d,6H),0.94(d,3H).LC-MS(m / z,ESI):543.24(M + H) + .

[0790] Example 5: Preparation of Compounds 29.20 and 29.43

[0791]

[0792] 1) Preparation of tert-butyl (2-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)propyl)carbamate (Compound 29.20)

[0793] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 4.99 g (28.5 mmol) of N-tert-butyloxycarbonyl-1,3-propylenediamine. Stirring was started, and the mixture was reacted in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was performed with water and dichloromethane, and the organic phase was retained. Anhydrous magnesium sulfate was added to dry, desolventized and concentrated to obtain 7.06 g of a white solid, which was compound 29.20. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.05(s,1H),7.99(d,1H),6.76(t,1H),6.61(s,1H),3.42(s,3H),2 .95-2.83(m,4H),1.60-1.48(m,2H),1.37(s,9H).LC-MS(m / z,ESI):581.12(M+Na) + .

[0794] 2) Preparation of N-(2-aminopropyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride

[0795] 7.06 g of tert-butyl (2-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)propyl)carbamate (Compound 29.20) was placed in a 250 ml single-necked round-bottom flask, and 150 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 6.17 g of light yellow colloidal solid was obtained.

[0796] 3) Preparation of compound 29.43

[0797] 0.30 g (0.61 mmol) of N-(2-aminoethyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.22 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 52 mg (0.67 mmol) of benzoyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.23 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.42(t,1H),8.20(d,1H),8.12(t,1H),7.98(d,1H),7.83-7.78(m,2H),7.53-7.49(m,1H),7.48-7.42(m, 2H),6.59(s,1H),3.41(s,3H),3.25(q,2H),2.94(q,2H),1.73-1.63(m,2H).LC-MS(m / z,ESI):562.07(M+H) + .

[0798] With reference to the preparation of compound 29.43 in Example 5, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[0799] Compound 29.1:

[0800]

[0801] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.18(d,1H),8.07(t,1H),7.97(d,1H),7.75(t,1H),6.59(s,1H),3.40(s,3H),2.9 9(q,2H),2.86(q,2H),1.75(s,3H),1.55-1.47(m,2H).LC-MS(m / z,ESI):500.94(M+H) + .

[0802] Compound 29.2:

[0803]

[0804] White solid. 1 H NMR (600 MHz, DMSO-d6 )δ8.20(d,1H),8.09(t,1H),8.00(d,1H),7.70(t,1H),6.61(s,1H),3.43(s,3H),3.02(q,2H ),2.88(q,2H),2.04(q,2H),1.59-1.49(m,2H),0.97(t,3H).LC-MS(m / z,ESI):515.07(M+H) + .

[0805] Compound 29.3:

[0806]

[0807] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.08(t,1H),8.00(d,1H),7.72(t,1H),6.61(s,1H),3.43(s,3H),3.03(q,2H),2.9 2-2.84(m,2H),2.03-1.98(m,2H),1.58-1.44(m,4H),0.83(t,3H).LC-MS(m / z,ESI):529.08(M+H) + .

[0808] Compound 29.4:

[0809]

[0810] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.18(d,1H),8.05(t,1H),7.98(d,1H),7.65(t,1H),6.59(s,1H),3.41(s,3H),3.00(q,2H),2.8 8-2.81(m,2H),2.31-2.25(m,1H),1.55-1.48(m,2H),0.95(d,6H).LC-MS(m / z,ESI):529.10(M+H) + .

[0811] Compound 29.5:

[0812]

[0813] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.18(d,1H),8.06(t,1H),7.98(d,1H),7.71(t,1H),6.59(s,1H),3.41(s,3H),3.00(q,2H),2.86(q,2H),2.0 1(t,2H),1.55-1.48(m,2H),1.47-1.39(m,2H),1.26-1.18(m,2H),0.83(t,3H).LC-MS(m / z,ESI):543.03(M+H) + .

[0814] Compound 29.8:

[0815]

[0816] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.04(t,1H),8.00(d,1H),7.42(t,1H),6.61(s,1H),3.42(s,3H),3.0 4(q,2H),2.86(q,2H),1.59-1.51(m,2H),1.06(s,9H).LC-MS(m / z,ESI):543.03(M+H) + .

[0817] Compound 29.9:

[0818]

[0819] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.18(d,1H),8.07(t,1H),8.01-7.96(m,2H),6.59(s,1H),3.41(s,3H),3.03(q,2H),2.90-2.8 2(m,2H),1.58-1.50(m,2H),1.50-1.44(m,1H),0.66-0.56(m,4H).LC-MS(m / z,ESI):527.09(M+H) + .

[0820] Compound 29.10:

[0821]

[0822] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.19(d,1H),8.07(t,1H),8.00(d,1H),7.58(t,1H),6.61(s,1H),3.42(s,3H),3.02(q,2H),2.98-2.90(m,1H),2.89-2.81(m,2 H),2.14-2.04(m,2H),2.02-1.94(m,2H),1.90-1.80(m,1H),1.77-1.70(m,1H),1.56-1.48(m,2H).LC-MS(m / z,ESI):541.05(M+H) + .

[0823] Compound 29.11:

[0824]

[0825] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.07(t,1H),8.00(d,1H),7.70(t,1H),6.61(s,1H),3.43(s,3H),3.03(q,2H),2.8 7(q,2H),2.56-2.45(m,1H),1.75-1.64(m,2H),1.64-1.43(m,8H).LC-MS(m / z,ESI):555.08(M+H) + .

[0826] Compound 29.21:

[0827]

[0828] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.11(t,1H),8.05(t,1H),7.99(d,1H),6.60(s,1H),6.21-6.13(m,1H),6.08-6.02(m,1H) ,5.56(dd,1H),3.41(s,3H),3.11(q,2H),2.89(q,2H),1.61-1.54(m,2H).LC-MS(m / z,ESI):512.98(M+H) + .

[0829] Compound 29.28:

[0830]

[0831] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.17(t,1H),8.12(t,1H),8.00(d,1H),6.61(s,1H),4.02(s,2H),3.42(s ,3H),3.09(q,2H),2.92-2.86(m,2H),1.61-1.53(m,2H).LC-MS(m / z,ESI):535.04(M+H) + .

[0832] Compound 29.46:

[0833]

[0834] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.43(t,1H),8.19(d,1H),8.11(t,1H),7.97(d,1H),7.88-7.84(m,2H),7.31-7.23(m,2H),6.58(s ,1H),3.40(s,3H),3.23(q,2H),2.95-2.90(m,2H),1.70-1.63(m,2H).LC-MS(m / z,ESI):581.03(M+H) + .

[0835] Compound 29.363:

[0836]

[0837] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.11(t,1H),7.97(d,1H),6.98(t,1H),6.58(s,1H),3.39(s,3H),2.98-2.87(m ,4H),2.47-2.42(m,1H),1.62-1.58(m,2H),0.92-0.82(m,4H).LC-MS(m / z,ESI):563.02(M+H) + .

[0838] Compound 29.379:

[0839]

[0840] White solid. 1H NMR (600 MHz, DMSO-d 6 )δ9.37(s,1H),8.24-8.15(m,2H),8.01(d,1H),6.61(s,1H),3.43(s,3H),3.2 0-3.13(m,2H),2.94(q,2H),1.72-1.63(m,2H).LC-MS(m / z,ESI):591.01(M+H) + .

[0841] Compound 29.397:

[0842]

[0843] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.10(t,1H),7.98(d,1H),7.79-7.76(m,2H),7.67-7.63(m,1H),7.61-7.58(m,3H),6 .61(s,1H),3.42(s,3H),2.86(q,2H),2.74(q,2H),1.58-1.51(m,2H).LC-MS(m / z,ESI):599.06(M+H) + .

[0844] Compound 29.403:

[0845]

[0846] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.09(t,1H),7.97(d,1H),7.66-7.62(m,2H),7.49(t,1H),7.39(d,2H),6.60(s,1H),3 .42(s,3H),2.85(q,2H),2.70(q,2H),2.39(s,3H),1.58-1.50(m,2H).LC-MS(m / z,ESI):613.10(M+H) + .

[0847] Example 6: Preparation of Compounds 57.20 and 57.43

[0848]

[0849] 1) Preparation of tert-butyl (2-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)butyl)carbamate (Compound 57.20)

[0850] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction bottle, followed by 4.59 g (28.5 mmol) of N-tert-butyloxycarbonyl-1,4-butanediamine, and stirring was started. The mixture was reacted in an ice bath for 0.5 hours. TLC detected that the reaction was complete. The mixture was extracted with water and dichloromethane, and the organic phase was retained. It was dried over anhydrous magnesium sulfate, desolventized and concentrated to obtain 7.12 g of a white solid, which was compound 57.20. 1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.07(t,1H),7.96(d,1H),6.72(t,1H),6.59(s,1H),3.40(s, 3H),2.90-2.77(m,4H),1.37-1.29(m,13H).LC-MS(m / z,ESI):595.13(M+Na) + .

[0851] 2) Preparation of N-(2-aminobutyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride

[0852] 7.12 g of (2-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)butyl)carbamate tert-butylcarbamate (Compound 57.20) was placed in a 250 ml single-necked round-bottom flask, and 150 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After reacting for 1 hour, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 6.20 g of a light yellow colloidal solid was obtained.

[0853] 3) Preparation of compound 57.43

[0854] Take 0.30 g (0.65 mmol) of N-(2-aminoethyl)-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride and place it in a 25 mL round-bottom flask. Add 10 mL of dichloromethane to dissolve it. After it is completely dissolved, add 0.12 g (1.30 mmol) of triethylamine dropwise to the above reaction flask. After the addition is complete, add 50 mg (0.72 mmol) of benzoyl chloride to the reaction system. Stir at room temperature for 0.5 h. Monitor the reaction by TLC until it is complete. Extract the reaction solution with water and dichloromethane, concentrate by evaporation, and purify by column chromatography to obtain 0.24 g of a white solid. 1 H NMR(600MHz,DMSO-d 6 )δ8.42(t,1H),8.20(d,1H),8.12(t,1H),7.97(d,1H),7.85 - 7.80(m,2H),7.54 - 7.50(m,1H),7.48 - 7.43(m,2H),6.60(s,1H),3.42(s,3H),3.21(q,2H),2.91(q,2H),1.54 - 1.42(m,4H).LC-MS(m / z,ESI):577.09(M+H) + .

[0855] Referring to the preparation of compound 57.43 in Example 6, the physical and chemical properties, NMR data, and mass spectrometry data of some compounds of the present invention are as follows:

[0856] Compound 57.1:

[0857]

[0858] White solid. 1 H NMR(600MHz,DMSO-d 6 )δ8.17(d,1H),8.09(t,1H),7.97(d,1H),7.73(t,1H),6.59(s,1H),3.40(s,3H),2.94(q,2H),2.85(q,2H),1.75(s,3H),1.39 - 1.29(m,4H).LC-MS(m / z,ESI):515.03(M+H) + .

[0859] Compound 57.2:

[0860]

[0861] White solid. 1 H NMR(600MHz,DMSO-d6 ) δ 8.17 (d, 1H), 8.09 (t, 1H), 7.97 (d, 1H), 7.65 (t, 1H), 6.59 (s, 1H), 3.41 (s, 3H), 2.95 (q, 2H), 2.85 (q, 2H), 2.02 (q, 2H), 1.41 - 1.30 (m, 4H), 0.96 (t, 3H). LC-MS (m / z, ESI): 529.03 (M + H) + .

[0862] Compound 57.3:

[0863]

[0864] White solid. 1 H NMR (600 MHz, DMSO-d 6 ) δ 8.17 (d, 1H), 8.09 (t, 1H), 7.97 (d, 1H), 7.68 (t, 1H), 6.59 (s, 1H), 3.40 (s, 3H), 2.96 (q, 2H), 2.85 (q, 2H), 2.02 - 1.95 (m, 2H), 1.52 - 1.43 (m, 2H), 1.40 - 1.30 (m, 4H), 0.82 (t, 3H). LC-MS (m / z, ESI): 543.02 (M + H) + .

[0865] Compound 57.4:

[0866]

[0867] White solid. 1 H NMR (600 MHz, DMSO-d 6 ) δ 8.17 (d, 1H), 8.09 (t, 1H), 7.97 (d, 1H), 7.62 (t, 1H), 6.59 (s, 1H), 3.41 (s, 3H), 2.95 (q, 2H), 2.85 (q, 2H), 2.35 - 2.24 (m, 1H), 1.41 - 1.29 (m, 4H), 0.96 (d, 6H). LC-MS (m / z, ESI): 543.08 (M + H) + .

[0868] Compound 57.5:

[0869]

[0870] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.19(d,1H),8.11(t,1H),7.99(d,1H),7.70(t,1H),6.61(s,1H),3.42(s,3H),2.97(q,2H),2.86(q,2H),2.04- 1.96(m,2H),1.49-1.42(m,2H),1.41-1.32(m,4H),1.29-1.20(m,2H),0.86(t,3H).LC-MS(m / z,ESI):557.09(M+H) + .

[0871] Compound 57.9:

[0872]

[0873] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.11(t,1H),8.02-7.93(m,2H),6.61(s,1H),3.42(s,3H),3.00(q,2H),2.87(q ,2H),1.54-1.46(m,1H),1.43-1.32(m,4H),0.66-0.58(m,4H).LC-MS(m / z,ESI):541.06(M+H) + .

[0874] Compound 57.10:

[0875]

[0876] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.09(t,1H),7.97(d,1H),7.54(t,1H),6.59(s,1H),3.41(s,3H),2.98-2.89(m,3H),2.84(q,2H),2.12- 2.03(m,2H),2.01-1.93(m,2H),1.89-1.79(m,1H),1.75-1.67(m,1H),1.40-1.29(m,4H).LC-MS(m / z,ESI):555.09(M+H) + .

[0877] Compound 57.21:

[0878]

[0879] White solid.1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.10(t,1H),8.01(t,1H),7.96(d,1H),6.58(s,1H),6.20-6.12(m,1H),6.07-5.99(m,1H) ,5.54(dd,1H),3.40(s,3H),3.05(q,2H),2.86(q,2H),1.42-1.32(m,4H).LC-MS(m / z,ESI):526.97(M+H) + .

[0880] Compound 57.363:

[0881]

[0882] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.13(t,1H),8.00(d,1H),6.99(t,1H),6.61(s,1H),3.43(s,3H),2.97-2.84(m ,4H),2.50-2.48(m,1H),1.48-1.41(m,4H),0.95-0.85(m,4H).LC-MS(m / z,ESI):577.05(M+H) + .

[0883] Compound 57.397:

[0884]

[0885] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.08(t,1H),7.98(d,1H),7.80-7.76(m,2H),7.66-7.62(m,1H),7.61-7.55(m,3H),6.60(s ,1H),3.42(s,3H),2.83-2.77(m,2H),2.71-2.65(m,2H),1.41-1.32(m,4H).LC-MS(m / z,ESI):613.09(M+H) + .

[0886] Compound 57.403:

[0887]

[0888] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.17(d,1H),8.08(t,1H),7.98(d,1H),7.67-7.63(m,2H),7.47(t,1H),7.39(d,2H),6.60(s,1H),3 .42(s,3H),2.81(q,2H),2.65(q,2H),2.39(s,3H),1.41-1.31(m,4H).LC-MS(m / z,ESI):627.07(M+H) + .

[0889] Example 7: Preparation of Compounds 85.1 and 85.35

[0890]

[0891] 1) Preparation of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)piperidine-1-carboxylate (Compound 85.35)

[0892] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 5.72 g (26.3 mmol) of 4-amino-1-tert-butyloxycarbonylpiperidine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried over anhydrous magnesium sulfate, desolventized and concentrated to obtain 12.63 g of a white solid, which was compound 85.35. 1 H NMR(600MHz,Chloroform-d)δ8.06(d,1H),7.45(d,1H),6.37(s,1H),4.92(d,1H),4.05-3.82(m,2H),3.57(s,3H),3.3 9-3.29(m,1H),2.92-2.71(m,2H),1.84-1.70(m,2H),1.43(s,9H),1.42-1.31(m,2H).LC-MS(m / z,ESI):607.16(M+Na) + .

[0893] 2) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride

[0894] 12.63 g of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)piperidine-1-carboxylate (Compound 85.35) was placed in a 250 ml single-mouth round-bottom flask, and 250 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[0895] 3) Preparation of Compound 85.1

[0896] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.16 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 97 mg (0.63 mmol) of methyl bromoacetate was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.23 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.23(d,1H),8.19(d,1H),7.99(d,1H),6.61(s,1H),3.59(s,3H),3.42(s,3H),3.16(s,2H),3.02- 2.93(m,1H),2.76-2.68(m,2H),2.13-2.04(m,2H),1.58-1.45(m,4H).LC-MS(m / z,ESI):557.09(M+H) + .

[0897] Example 8: Preparation of Compound 85.7

[0898]

[0899] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride

[0900] 12.63 g of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)piperidine-1-carboxylate (Compound 85.35) was placed in a 250 ml single-mouth round-bottom flask, and 150 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[0901] 2) Preparation of compound 85.7

[0902] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of ethanol was added to dissolve and dilute. After it was completely dissolved, 0.09 g (0.73 mmol) of ethoxymethylene malononitrile was added dropwise to the above reaction flask. The mixture was stirred at room temperature and the reaction was carried out for 2.5 hours. The reaction was completed as monitored by TLC. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.17 g of a yellow solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.36(d,1H),8.23(d,1H),8.00(d,1H),7.64(s,1H),6.60(d,1H),4.19-4.11(m,1H),3.41(s,3H),3.4 0-3.34(m,2H),3.15-3.02(m,2H),1.85-1.69(m,2H),1.59-1.48(m,2H).LC-MS(m / z,ESI):561.24(M+H) + .

[0903] Example 9: Preparation of Compound 85.12

[0904]

[0905] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride

[0906] 12.63 g of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)piperidine-1-carboxylate (Compound 85.35) was placed in a 250 ml single-mouth round-bottom flask, and 150 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[0907] 2) Preparation of compound 85.12

[0908] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of N,N-dimethylformamide was added to dissolve and dilute. After it was completely dissolved, 0.16 g (1.19 mmol) of potassium carbonate and 78 mg (0.65 mmol) of bromoacetonitrile were added to the above reaction flask. The mixture was stirred at room temperature and the reaction was carried out for 1.5 hours. The reaction was completed as monitored by TLC. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.20 g of a yellow solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.27-8.17(m,2H),7.99(d,1H),6.61(s,1H),3.65(s,2H),3.42(s,3H),3.05-2.95(m,1H),2.75-2 .65(m,2H),2.15-2.03(m,2H),1.64-1.56(m,2H),1.55-1.46(m,2H).LC-MS(m / z,ESI):524.21(M+H) + .

[0909] Example 10: Preparation of Compound 85.58

[0910]

[0911] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride

[0912] 12.63 g of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)piperidine-1-carboxylate (Compound 85.35) was placed in a 250 ml single-mouth round-bottom flask, and 150 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[0913] 2) Preparation of compound 85.58

[0914] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.16 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 54 mg (0.64 mmol) of benzoyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.19 g of a white solid. 1 H NMR(600MHz,Chloroform-d)δ8.06(d,1H),7.45(d,1H),7.42-7.30(m,5H),6.36(s,1H),5.12-5.02(m,1H),4.63-4.33(m,1H),3.83-3.5 9(m,1H),3.58-3.53(m,3H),3.49-3.37(m,1H),3.16-3.87(m,2H),1.97-1.72(m,2H),1.54-1.36(m,2H).LC-MS(m / z,ESI):589.26(M+H) + .

[0915] With reference to the preparation of compound 85.58 in Example 10, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[0916] Compound 85.16:

[0917]

[0918] White solid. 1H NMR(600MHz,Chloroform-d)δ8.06(d,1H),7.46(d,1H),6.37(s,1H),5.07(d,1H),4.40-4.33(m,1H),3.75-3.66(m,1H),3.57(s,3H),3.47- 3.34(m,1H),3.13-3.03(m,1H),2.78-2.68(m,1H),2.07-2.05(m,3H),1.92-1.76(m,2H),1.48-1.32(m,2H).LC-MS(m / z,ESI):527.04(M+H) + .

[0919] Compound 85.17:

[0920]

[0921] White solid. 1 H NMR(600MHz,Chloroform-d)δ8.05(d,1H),7.44(d,1H),6.35(s,1H),5.50-5.41(m,1H),4.39-4.33(m,1H),3.74-3.69(m,1H),3.55(s,3H),3.44-3.3 3(m,1H),3.09-2.97(m,1H),2.79-2.66(m,1H),2.35-2.26(m,2H),1.85-1 .75(m,2H),1.41-1.34(m,2H),1.09(t,3H).LC-MS(m / z,ESI):541.07(M+H) + .

[0922] Compound 85.18:

[0923]

[0924] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.26-8.20(m,2H),8.00(d,1H),6.61(s,1H),4.21-4.12(m,1H),3.79-3 .71(m,1H),3.42(s,3H),3.32-3.23(m,1H),3.02-2.93(m,1H),2.67-2.58 (m,1H),2.26-2.19(m,2H),1.67-1.57(m,2H),1.52-1.43(m,2H),1.41-1. 32(m,1H),1.32-1.23(m,1H),0.86(t,3H).LC-MS(m / z,ESI):555.27(M+H) + .

[0925] Compound 85.19:

[0926]

[0927] White solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.23(d,2H),7.99(d,1H),6.60(s,1H),4.22-4.10(m,1H),3.88-3.75(m,1H),3.41(s,3H),3.31-3.25(m,1H),3.07-2.95(m,1H ),2.87-2.77(m,1H),2.66-2.56(m,1H),1.70-1.55(m,2H),1.43-1.20(m,2H),1.00-0.88(m,6H).LC-MS(m / z,ESI):555.27(M+H) + .

[0928] Compound 85.24:

[0929]

[0930] White solid. 1H NMR(600MHz,Chloroform-d)δ8.07(d,1H),7.45(d,1H),6.37(s,1H),4.41-4.25 (m,1H),4.12-3.97(m,1H),3.56(s,3H),3.49-3.36(m,1H),3.19-3.09(m,1H),2. 82-2.68(m,1H),1.96-1.75(m,2H),1.53-1.42(m,1H),1.29-1.14(m,1H),1.05-1 .00(m,1H),0.97-0.91(m,2H),0.76-0.71(m,2H).LC-MS(m / z,ESI):553.22(M+H) + .

[0931] Compound 85.25:

[0932]

[0933] White solid. 1 H NMR(600MHz,Chloroform-d)δ8.05(d,1H),7.44(d,1H),6.36(s,1H),5.42-5.35(m ,1H),4.38-4.28(m,1H),3.61-3.52(m,4H),3.43-3.31(m,1H),3.23-3.13(m,1H), 2.99-2.89(m,1H),2.76-2.68(m,1H),2.35-2.23(m,2H),2.13-2.07(m,2H),1.97- 1.88(m,1H),1.86-1.73(m,3H),1.40-1.31(m,2H).LC-MS(m / z,ESI):567.19(M+H) + .

[0934] Compound 85.26:

[0935]

[0936] White solid. 1H NMR(600MHz,Chloroform-d)δ8.06(d,1H),7.45(d,1H),6.36(s,1H),5.32-5.25 (m,1H),4.43-4.33(m,1H),3.89-3.78(m,1H),3.56(s,3H),3.46-3.35(m,1H),3. 13-2.98(m,1H),2.88-2.78(m,1H),2.77-2.67(m,1H),1.92-1.72(m,6H),1.72-1 .64(m,2H),1.60-1.49(m,2H),1.47-1.32(m,2H).LC-MS(m / z,ESI):581.27(M+H) + .

[0937] Compound 85.28:

[0938]

[0939] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.28-8.22(m,2H),8.00(d,1H),6.62(s,1H),3.88-3.72(m,2H),3.57(s,3H),3.43(s,3H),3.30-3 .21(m,1H),2.97-2.72(m,2H),1.66-1.57(m,2H),1.40-1.30(m,2H).LC-MS(m / z,ESI):543.01(M+H) + .

[0940] Compound 85.29:

[0941]

[0942] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.26-8.21(m,2H),8.00(d,1H),6.61(s,1H),4.04-3.96(m,2H),3.84-3.76(m,2H),3.42(s,3H),3.30-3.18 (m,1H),2.89-2.73(m,2H),1.63-1.57(m,2H),1.37-1.30(m,2H),1.16(t,3H).LC-MS(m / z,ESI):579.18(M+Na) + .

[0943] Compound 85.36:

[0944]

[0945] White solid. 1 H NMR(600MHz,Chloroform-d)δ8.07(d,1H),7.46(d,1H),6.55 - 6.48(m,1H),6.37(s,1H),6.29 - 6.22(m,1H),5.68(dd,1H),5.09 - 4.94(m,1H),4.52 - 4.33(m,1H),3.99 - 3.80(m,1H),3.59 - 3.55(m,3H),3.49 - 3.38(m,1H),3.19 - 3.03(m,1H),2.89 - 2.74(m,1H),1.96 - 1.78(m,2H),1.47 - 1.34(m,2H).LC-MS(m / z,ESI):539.25(M + H) + .

[0946] Compound 85.55:

[0947]

[0948] White solid. 1 H NMR(600MHz,DMSO-d 6 )δ8.68 - 8.63(m,2H),8.31(d,1H),8.24(d,1H),7.99(d,1H),7.34 - 7.31(m,2H),6.61(s,1H),4.29 - 4.17(m,1H),3.42(s,3H),3.40 - 3.28(m,2H),3.10 - 3.00(m,1H),2.99 - 2.89(m,1H),1.80 - 1.70(m,1H),1.68 - 1.55(m,1H),1.54 - 1.43(m,1H),1.42 - 1.33(m,1H).LC-MS(m / z,ESI):590.24(M + H) + .

[0949] Compound 85.56:

[0950]

[0951] White solid. 1 H NMR(600MHz,DMSO-d 6)δ8.66-8.63(m,1H),8.58-8.54(m,1H),8.31(d,1H),8.24(d,1H),8.00 (d,1H),7.80-7.76(m,1H),7.50-7.45(m,1H),6.61(s,1H),4.26-4.19(m ,1H),3.52-3.43(m,1H),3.42(s,3H),3.39-3.34(m,1H),3.17-2.87(m,2 H),1.81-1.56(m,2H),1.55-1.33(m,2H).LC-MS(m / z,ESI):590.19(M+H) + .

[0952] Compound 85.57:

[0953]

[0954] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.31(d,1H),8.27(d,1H),8.24(d,1H),8.03-7.96(m,2H),7.30-7.24(m,1H),6.60(s,1H),4.31-4.13(m,1H),3.56-3.45(m ,1H),3.42(s,3H),3.39-3.28(m,1H),3.18-2.86(m,2H),1.83-1.56(m,2H),1.55-1.33(m,2H).LC-MS(m / z,ESI):608.23(M+H) + .

[0955] Compound 85.59:

[0956]

[0957] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.30(d,1H),8.23(d,1H),7.99(d,1H),7.53-7.45(m,1H),7.38-7.33(m,1H),7 .32-7.24(m,2H),6.61(d,1H),4.32-4.20(m,1H),3.42(d,3H),3.39-3.32(m,1H), 3.29-3.26(m,1H),3.10-2.96(m,1H),2.95-2.87(m,1H),1.76-1.68(m,1H),1.65- 1.54(m,1H),1.52-1.40(m,1H),1.39-1.29(m,1H).LC-MS(m / z,ESI):607.22(M+H) + .

[0958] Compound 85.60:

[0959]

[0960] White solid. 1 H NMR(600MHz,Chloroform-d)δ8.11-8.02(m,1H),7.50-7.41(m,1H),7.41-7.34(m,1H),7.19-7.01(m,3H),6.37(s,1H),5.56-5.48(m,1H),4.61-4.3 5(m,1H),3.87-3.60(m,1H),3.57(s,3H),3.51-3.39(m,1H),3.18-2.89(m ,2H),2.02-1.67(m,2H),1.64-1.33(m,2H).LC-MS(m / z,ESI):607.22(M+H) + .

[0961] Compound 85.61:

[0962]

[0963] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.29(d,1H),8.24(d,1H),7.99(d,1H),7.44-7.38(m,2H),7.31-7.22(m,2H),6.61(s,1H),4.40-4.08(m,1H),3.63-3.44(m ,1H),3.42(s,3H),3.39-3.30(m,1H),3.17-2.76(m,2H),1.81-1.55(m,2H),1.54-1.32(m,2H).LC-MS(m / z,ESI):607.32(M+H) + .

[0964] Compound 85.62:

[0965]

[0966] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.27(d,1H),8.23(d,1H),7.99(d,1H),7.34-7.17(m,3H),7.09(d,1H),6 .61(d,1H),4.33-4.25(m,1H),3.42(d,3H),3.28-3.15(m,1H),3.01-2.83(m ,2H),2.25-2.07(m,3H),1.76-1.66(m,1H),1.61-1.51(m,1H),1.50-1.40( m,1H),1.37-1.27(m,1H),1.25-1.15(m,1H).LC-MS(m / z,ESI):603.22(M+H) + .

[0967] Compound 85.63:

[0968]

[0969] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.26(d,1H),8.22(d,1H),7.97(d,1H),7.33-7.27(m,1H),7.26-7.22(m,1H),7.13(s,1H),7.11-7.06(m,1H),6.59(s,1H),4.37-4 .10(m,1H),3.60-3.36(m,5H),3.13-2.77(m,2H),2.31(s,3H),1.83-1.50(m,2H),1.50-1.28(m,2H).LC-MS(m / z,ESI):603.22(M+H) + .

[0970] Compound 85.64:

[0971]

[0972] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.27(d,1H),8.23(d,1H),7.98(d,1H),7.27-7.19(m,4H),6.60(s,1H),4.44-4.07(m,1H),3.74-3.44(m,1H),3.41(s ,3H),3.38-3.30(m,1H),2.99(d,2H),2.32(s,3H),1.81-1.52(m,2H),1.51-1.27(m,2H).LC-MS(m / z,ESI):603.22(M+H) + .

[0973] Compound 85.378:

[0974]

[0975] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.37-8.19(m,2H),8.02(d,1H),6.62(s,1H),3.52-3.45(m,2H),3.43(s,3H),3.27-3.20(m,1H),2.92-2.82(m ,2H),2.56-2.52(m,1H),1.77-1.67(m,2H),1.59-1.48(m,2H),0.99-0.86(m,4H).LC-MS(m / z,ESI):589.05(M+H) + .

[0976] Example 11: Preparation of Compounds 89.1 and 89.35

[0977]

[0978] 1) Preparation of tert-butyl 4-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)methyl)piperidine-1-carboxylate (Compound 89.35)

[0979] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction bottle, followed by 6.13 g (28.6 mmol) of 1-tert-butyloxycarbonyl-4-aminomethylpiperidine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 12.69 g of white solid, which was compound 89.35. 1 H NMR(600MHz,Chloroform-d)δ8.04(d,1H),7.45(d,1H),6.37(s,1H),5.10-5.01(m,1H),4.25-3.92(m,2H),3.60-3.53(m,3H),2.95-2 .81(m,2H),2.74-2.54(m,2H),1.72-1.63(m,2H),1.63-1.53(m,1H),1.44(s,9H),1.23-1.02(m,2H).LC-MS(m / z,ESI):621.18(M+Na) + .

[0980] 2) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride

[0981] 12.69 g of tert-butyl 4-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)methyl)piperidine-1-carboxylate (Compound 89.35) was placed in a 250 ml single-necked round-bottom flask, and 150 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After reacting for 1 hour, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.62 g of a light yellow colloidal solid was obtained.

[0982] 3) Preparation of Compound 89.1

[0983] 0.30 g (0.56 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.12 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 0.11 g (0.72 mmol) of methyl bromoacetate was added to the reaction system, stirred at room temperature, and the reaction was carried out for 0.5 hour. The reaction was completed by TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.18 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.21-8.14(m,2H),7.99(d,1H),6.62(s,1H),3.60(s,3H),3.43(s,3H),3.16(s,2H),2.79-2.71(m,4H), 2.07-1.99(m,2H),1.59-1.52(m,2H),1.35-1.26(m,1H),1.09-0.99(m,2H).LC-MS(m / z,ESI):571.10(M+H) + .

[0984] Example 11: Preparation of Compound 89.7

[0985]

[0986] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride

[0987] 12.69 g of tert-butyl 4-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)methyl)piperidine-1-carboxylate (Compound 89.35) was placed in a 250 ml single-necked round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that the solution was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.62 g of a light yellow colloidal solid was obtained.

[0988] 2) Preparation of Compound 89.7

[0989] 0.30 g (0.56 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of ethanol was added to dissolve and dilute. After it was completely dissolved, 0.11 g (0.72 mmol) of ethoxymethylene malononitrile was added dropwise to the above reaction flask. The mixture was stirred at room temperature and the reaction was carried out for 2.5 hours. The reaction was completed as monitored by TLC. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.17 g of a yellow solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.36-8.15(m,2H),8.01(d,1H),7.66(s,1H),6.62(d,1H),4.34-4.25(m,1H),3.76-3.67(m,1H),3.43(s,3H),3.30-3.22(m,1H ),3.19-3.10(m,1H),2.88-2.78(m,2H),1.79-1.63(m,2H),1.45-1.39(m,1H),1.28-1.14(m,2H).LC-MS(m / z,ESI):575.02(M+H) + .

[0990] Example 12: Preparation of Compound 89.11

[0991]

[0992] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride

[0993] 12.69 g of tert-butyl 4-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)methyl)piperidine-1-carboxylate (Compound 89.35) was placed in a 250 ml single-necked round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that the solution was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.62 g of a light yellow colloidal solid was obtained.

[0994] 2) Preparation of compound 89.11

[0995] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of N,N-dimethylformamide was added to dissolve and dilute. After it was completely dissolved, 0.16 g (1.19 mmol) of potassium carbonate and 0.07 g (0.59 mmol) of propyne bromide were added to the above reaction flask. The mixture was stirred at room temperature and the reaction was carried out for 1.5 hours. The reaction was completed as monitored by TLC. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.20 g of a yellow solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.18(d,1H),8.16(t,1H),7.98(d,1H),6.60(s,1H),3.42(s,3H),3.21-3.17(m,2H),3.10-3.07(m,1H),2.78-2.74(m,2H), 2.73-2.69(m,2H),2.02-1.94(m,2H),1.63-1.56(m,2H),1.36-1.25(m,1H),1.10-0.97(m,2H).LC-MS(m / z,ESI):537.16(M+H) + .

[0996] Example 13: Preparation of Compound 89.12

[0997]

[0998] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride

[0999] 12.69 g of tert-butyl 4-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)methyl)piperidine-1-carboxylate (Compound 89.35) was placed in a 250 ml single-necked round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that the solution was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.62 g of a light yellow colloidal solid was obtained.

[1000] 2) Preparation of compound 89.12

[1001] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of N,N-dimethylformamide was added to dissolve and dilute. After it was completely dissolved, 0.16 g (1.19 mmol) of potassium carbonate and 0.07 g (0.58 mmol) of bromoacetonitrile were added to the above reaction flask. The mixture was stirred at room temperature and the reaction was carried out for 1.5 hours. The reaction was completed as monitored by TLC. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.22 g of a yellow solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.21-8.16(m,2H),8.00(d,1H),6.61(s,1H),3.67-3.65(m,2H),3.43(s,3H),2.81-2.75(m,2H),2.74-2.70(m ,2H),2.09-2.01(m,2H),1.68-1.57(m,2H),1.42-1.27(m,1H),1.12-1.01(m,2H).LC-MS(m / z,ESI):538.15(M+H) + .

[1002] Example 14: Preparation of Compound 89.14

[1003]

[1004] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride

[1005] 12.69 g of tert-butyl 4-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)phenyl)sulfonamido)methyl)piperidine-1-carboxylate (Compound 89.35) was placed in a 250 mL single-necked round-bottom flask, and 120 mL of dichloromethane was added for dissolution. After complete dissolution, hydrochloric acid with a mass fraction of 36% was added dropwise using a dropping funnel, and the mixture was stirred at room temperature. The reaction was monitored by TLC. After 1 hour of reaction, TLC showed complete conversion to the hydrochloride salt, and the reaction was stopped. Extraction was carried out, and the aqueous phase was retained. After desolvation and concentration, 9.62 g of a pale yellow colloidal solid was obtained.

[1006] 2) Preparation of Compound 89.14

[1007] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)-N-(piperidin-4-ylmethyl)benzenesulfonamide hydrochloride was placed in a 25 mL round-bottom flask, and 10 mL of N,N-dimethylformamide was added for dissolution and dilution. After complete dissolution, 0.16 g (1.19 mmol) of potassium carbonate and 0.14 g (0.67 mmol) of iodoethane were added to the above reaction flask. The mixture was stirred at room temperature for 1.5 hours. The reaction was monitored by TLC and was found to be complete. The reaction solution was extracted with water and dichloromethane, desolvated and concentrated, and then purified by column chromatography to obtain 0.09 g of a white solid. 1 HNMR(600MHz,DMSO-d 6 )δ8.22 - 8.15(m,2H),7.99(d,1H),6.61(s,1H),3.42(s,3H),3.14 - 3.03(m,2H),2.86 - 2.80(m,2H),2.78 - 2.73(m,2H),2.24 - 2.17(m,2H),1.58 - 1.51(m,2H),1.36 - 1.27(m,1H),1.09 - 1.01(m,2H).LC-MS(m / z,ESI):581.12(M + H) + .

[1008] Example 15: Preparation of Compound 89.58

[1009]

[1010] 1) Preparation of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)-N-(piperidin-4-ylmethyl)benzenesulfonamide hydrochloride

[1011] 12.69 g of tert-butyl 4-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)methyl)piperidine-1-carboxylate (Compound 89.35) was placed in a 250 ml single-necked round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that the solution was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.62 g of a light yellow colloidal solid was obtained.

[1012] 2) Preparation of compound 89.58

[1013] 0.30 g (0.58 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-N-piperidin-4-ylmethylbenzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.16 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 54 mg (0.64 mmol) of benzoyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.19 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.24(t,1H),8.21(d,1H),7.99(d,1H),7.48-7.41(m,3H),7.37-7.30(m,2H),6.62(s,1H),4.53-4.44(m,1H),3.5 9-3.45(m,1H),3.42(s,3H),3.00-2.57(m,4H),1.76-1.42(m,3H),1.12-0.89(m,2H).LC-MS(m / z,ESI):603.19(M+H) + .

[1014] With reference to the preparation of compound 89.58 in Example 15, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[1015] Compound 89.16:

[1016]

[1017] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.26-8.17(m,2H),8.00(d,1H),6.62(d,1H),4.39-4.28(m,1H),3.83-3.72(m,1H),3.42(s,3H),2.91-2.85(m,1H),2.84-2.75 (m,2H),2.49-2.40(m,1H),1.95(s,3H),1.62-1.52(m,3H),1.01-0.95(m,1H),0.88-0.80(m,1H).LC-MS(m / z,ESI):541.16(M+H) + .

[1018] Compound 89.17:

[1019]

[1020] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.26-8.17(m,2H),8.00(d,1H),6.62(d,1H),4.37-4.28(m,1H),3.82-3.74(m,1H),3.42(s,3H),2.89-2.78(m,3H),2 .44-2.38(m,1H),2.32-2.22(m,2H),1.61-1.53(m,3H),0.96(t,3H),0.93-0.82(m,2H).LC-MS(m / z,ESI):555.12(M+H) + .

[1021] Compound 89.18:

[1022]

[1023] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.27-8.17(m,2H),7.99(d,1H),6.61(d,1H),4.35-4.27(m,1H),3.82-3.75(m,1H),3.42(s,3H),2.89-2.75(m,3H),2.4 3-2.35(m,1H),2.26-2.20(m,2H),1.63-1.53(m,3H),1.51-1.42(m,2H),0.99-0.80(m,5H).LC-MS(m / z,ESI):569.22(M+H) + .

[1024] Compound 89.19:

[1025]

[1026] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.27-8.16(m,2H),7.99(d,1H),6.63-6.59(m,1H),4.38-4.27(m,1H),3.92-3.81(m,1H),3.42(s,3H),2 .94-2.77(m,4H),2.45-2.35(m,1H),1.67-1.52(m,3H),1.03-0.78(m,8H).LC-MS(m / z,ESI):569.22(M+H) + .

[1027] Compound 89.24:

[1028]

[1029] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.26-8.17(m,2H),8.00(d,1H),6.62(s,1H),4.35-4.25(m,1H),4.2 3-4.13(m,1H),3.42(s,3H),3.02-2.89(m,1H),2.86-2.78(m,2H),2.4 9-2.40(m,1H),1.97-1.90(m,1H),1.69-1.53(m,3H),1.04-0.95(m,1H ),0.91-0.82(m,1H),0.72-0.62(m,4H).LC-MS(m / z,ESI):567.20(M+H) + .

[1030] Compound 89.25:

[1031]

[1032] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.22-8.17(m,2H),7.98(d,1H),6.60(d,1H),4.30-4.24(m,1H),3.64-3. 56(m,1H),3.41(s,3H),3.30-3.24(m,1H),2.81-2.74(m,3H),2.44-2.36(m ,1H),2.14-2.08(m,2H),2.06-1.99(m,2H),1.91-1.81(m,1H),1.74-1.66( m,1H),1.60-1.51(m,3H),0.91-0.79(m,2H).LC-MS(m / z,ESI):581.15(M+H) + .

[1033] Compound 89.26:

[1034]

[1035] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.25-8.17(m,2H),8.00(d,1H),6.62(d,1H),4.36-4.27(m,1H),3.94-3.85(m,1H),3.42(s,3H),2.97-2.76(m,4H),2.4 6-2.38(m,1H),1.76-1.68(m,2H),1.65-1.55(m,7H),1.53-1.45(m,2H),0.97-0.81(m,2H).LC-MS(m / z,ESI):595.17(M+H) + .

[1036] Compound 89.28:

[1037]

[1038] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.26-8.15(m,2H),7.98(d,1H),6.60(s,1H),3.99-3.80(m,2H),3.56(s,3H),3.42(s,3H),2.89-2 .75(m,2H),2.74-2.56(m,2H),1.61-1.48(m,3H),0.99-0.86(m,2H).LC-MS(m / z,ESI):557.16(M+H) + .

[1039] Compound 89.36:

[1040]

[1041] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.24-8.17(m,2H),7.98(d,1H),6.80-6.73(m,1H),6.61(s,1H),6.07-6.02(m,1H),5.63(dd,1H),4.39-4.28(m,1H),4.01-3.94(m,1H), 3.41(s,3H),2.97-2.85(m,1H),2.84-2.75(m,2H),2.55-2.51(m,1H),1.65-1.55(m,3H),0.99-0.85(m,2H).LC-MS(m / z,ESI):553.00(M+H) + .

[1042] Compound 89.43:

[1043]

[1044] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.24(t,1H),8.20(d,1H),8.00(d,1H),6.61(d,1H),4.37-4.28(m,2H),4.27-4.21(m,1H),3.81-3.72(m,1H),3.42(s,3H),2.97-2.8 8(m,1H),2.85-2.75(m,2H),2.57-2.51(m,1H),1.66-1.54(m,3H),1.10-0.98(m,1H),0.95-0.84(m,1H).LC-MS(m / z,ESI):575.08(M+H) + .

[1045] Compound 89.47:

[1046]

[1047] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.23-8.18(m,2H),7.99(d,1H),6.62-6.59(m,1H),4.30-4.22(m,1H),4.08-3.96(m,2H),3.74-3.67(m,1H),3.41(s,3H),3.25(s ,3H),2.85-2.75(m,3H),2.49-2.41(m,1H),1.61-1.52(m,3H),1.02-0.91(m,1H),0.91-0.81(m,1H).LC-MS(m / z,ESI):571.12(M+H) + .

[1048] Compound 89.54:

[1049]

[1050] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.68-8.62(m,2H),8.24(t,1H),8.20(d,1H),7.99(d,1H),7.36-7.31(m,2 H),6.61(s,1H),4.44-4.36(m,1H),3.42(s,3H),3.38-3.34(m,1H),2.97-2.8 9(m,1H),2.88-2.77(m,2H),2.71-2.63(m,1H),1.72-1.67(m,1H),1.66-1.58 (m,1H),1.55-1.47(m,1H),1.11-0.94(m,2H).LC-MS(m / z,ESI):604.14(M+H) + .

[1051] Compound 89.55:

[1052]

[1053] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.64(dd,1H),8.58-8.54(m,1H),8.24(t,1H),8.20(d,1H),7.99(d,1H),7.79 -7.76(m,1H),7.49-7.44(m,1H),6.61(s,1H),4.50-4.32(m,1H),3.53-3.43(m,1 H),3.42(s,3H),3.03-2.92(m,1H),2.88-2.78(m,2H),2.75-2.64(m,1H),1.73-1 .60(m,2H),1.58-1.47(m,1H),1.12-0.99(m,2H).LC-MS(m / z,ESI):604.13(M+H) + .

[1054] Compound 89.57:

[1055]

[1056] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.27(d,1H),8.24(t,1H),8.20(d,1H),8.02-7.96(m,2H),7.28-7.23 (m,1H),6.61(s,1H),4.49-4.33(m,1H),3.52-3.44(m,1H),3.42(s,3H), 3.05-2.91(m,1H),2.87-2.77(m,2H),2.74-2.61(m,1H),1.74-1.60(m,2 H),1.58-1.46(m,1H),1.12-0.96(m,2H).LC-MS(m / z,ESI):622.22(M+H) + .

[1057] Compound 89.59:

[1058]

[1059] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.24(t,1H),8.20(d,1H),7.99(d,1H),7.52-7.45(m,1H),7.39-7.33 (m,1H),7.31-7.25(m,2H),6.62(d,1H),4.48-4.40(m,1H),3.42(s,3H), 3.32-3.27(m,1H),2.99-2.88(m,1H),2.88-2.76(m,2H),2.72-2.64(m,1 H),1.76-1.45(m,3H),1.10-0.88(m,2H).LC-MS(m / z,ESI):621.05(M+H) + .

[1060] Compound 89.60:

[1061]

[1062] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.24(t,1H),8.21(d,1H),8.00(d,1H),7.52-7.46(m,1H),7.32-7.26(m,1H),7.22-7.15(m,2H),6.62(s,1H),4.45-4.33(m,1H),3.51-3 .39(m,4H),3.00-2.78(m,3H),2.73-2.60(m,1H),1.73-1.59(m,2H),1.59-1.44(m,1H),1.11-0.97(m,2H).LC-MS(m / z,ESI):621.11(M+H) + .

[1063] Compound 89.61:

[1064]

[1065] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.23(t,1H),8.20(d,1H),7.99(d,1H),7.44-7.37(m,2H),7.29-7.22(m,2H),6.61(s,1H),4.49-4.25(m,1H),3 .62-3.45(m,1H),3.41(s,3H),3.07-2.57(m,4H),1.79-1.43(m,3H),1.02(s,2H).LC-MS(m / z,ESI):621.23(M+H)+ .

[1066] Compound 89.62:

[1067]

[1068] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.26-8.21(m,1H),8.20(d,1H),7.99(d,1H),7.34-7.17(m,3H),7.17-7.05(m,1H),6.61(d,1H),4.53-4.43(m,1H),3.42(s,3H),3.27-3 .16(m,1H),2.90-2.76(m,3H),2.70-2.60(m,1H),2.25-2.10(m,3H),1.75-1.40(m,3H),1.13-0.80(m,2H).LC-MS(m / z,ESI):617.27(M+H) + .

[1069] Compound 89.63:

[1070]

[1071] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.28-8.17(m,2H),7.99(d,1H),7.31(t,1H),7.27-7.22(m,1H),7.17-7.08(m,2H),6.62(s,1H),4.53-4.26(m,1H),3.59-3.44(m,1H ),3.42(s,3H),2.95-2.77(m,3H),2.72-2.57(m,1H),2.33(s,3H),1.74-1.44(m,3H),1.13-0.97(m,2H).LC-MS(m / z,ESI):617.26(M+H) + .

[1072] Compound 89.64:

[1073]

[1074] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ 8.27 - 8.16 (m, 2H), 7.99 (d, 1H), 7.24 - 7.19 (m, 4H), 6.62 (s, 1H), 4.56 - 4.17 (m, 1H), 3.71 - 3.46 (m, 1H), 3.42 (s, 3H), 2.99 - 2.74 (m, 3H), 2.72 - 2.57 (m, 1H), 2.33 (s, 3H), 1.79 - 1.41 (m, 3H), 1.08 - 0.90 (m, 2H). LC-MS (m / z, ESI): 617.15 (M + H) + .

[1075] Compound 89.370:

[1076]

[1077] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ 8.26 (t, 1H), 8.21 (d, 1H), 8.00 (d, 1H), 6.62 (s, 1H), 3.52 - 3.46 (m, 2H), 3.42 (s, 3H), 2.86 - 2.81 (m, 5H), 2.62 - 2.55 (m, 2H), 1.71 - 1.63 (m, 2H), 1.51 - 1.41 (m, 1H), 1.14 - 1.03 (m, 2H). LC-MS (m / z, ESI): 577.06 (M + H) + .

[1078] Compound 89.371:

[1079]

[1080] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ 8.24 (t, 1H), 8.20 (d, 1H), 7.99 (d, 1H), 6.61 (s, 1H), 3.55 - 3.49 (m, 2H), 3.41 (s, 3H), 3.03 - 2.95 (m, 2H), 2.84 - 2.78 (m, 2H), 2.70 - 2.62 (m, 2H), 1.68 - 1.59 (m, 2H), 1.51 - 1.41 (m, 1H), 1.18 (t, 3H), 1.09 - 0.98 (m, 2H). LC-MS (m / z, ESI): 591.10 (M + H) + .

[1081] Compound 89.372:

[1082]

[1083] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.25(t,1H),8.21(d,1H),8.00(d,1H),6.62(s,1H),3.96-3.49(m,2H),3.43(s,3H),2.98-2.93(m,2H),2.85-2.78(m,2H ),2.69-2.62(m,2H),1.70-1.62(m,4H),1.52-1.43(m,1H),1.10-1.00(m,2H),0.98(t,3H).LC-MS(m / z,ESI):605.23(M+H) + .

[1084] Compound 89.378:

[1085]

[1086] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.24(t,1H),8.20(d,1H),7.99(d,1H),6.61(s,1H),3.55-3.51(m,2H),3.41(s,3H),2.85-2.79(m,2H),2.69-2.62(m,2H),2.53-2.5 1(m,1H),1.68-1.62(m,2H),1.51-1.42(m,1H),1.11-1.02(m,2H),0.98-0.93(m,2H),0.90-0.86(m,2H).LC-MS(m / z,ESI):603.08(M+H) + .

[1087] Compound 89.394:

[1088]

[1089] White solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.29(t,1H),8.21(d,1H),8.00(d,1H),6.62(s,1H),3.80-3.72(m,2H),3.43(s,3H),3.14-3.02(m,2H), 2.90-2.81(m,2H),1.77-1.68(m,2H),1.67-1.56(m,1H),1.15-1.05(m,2H).LC-MS(m / z,ESI):631.02(M+H) + .

[1090] Compound 89.418:

[1091]

[1092] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.22-8.12(m,2H),7.97(d,1H),7.60-7.56(m,2H),7.45-7.39(m,2H),6.59(s,1H),3.59-3.52(m,2H),3.40(s,3H),2.77-2.73 (m,2H),2.40(s,3H),2.14-2.06(m,2H),1.66-1.59(m,2H),1.33-1.23(m,1H),1.12-1.03(m,2H).LC-MS(m / z,ESI):653.08(M+H) + .

[1093] Example 16: Preparation of Compound 93.12

[1094]

[1095] 0.30 g (0.71 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 25 ml single-mouth round-bottom flask, and 10 ml of dichloromethane was added to dissolve. After the raw material was completely dissolved, 0.14 g (1.42 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 0.08 g (0.73 mmol) of 2-hydrazinepyridine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 0.16 g of white solid. 1 HNMR (600 MHz, DMSO-d 6)δ10.11(s,1H),8.63(s,1H),8.19(d,1H),7.98(d,1H),7.97-7.94(m,1H),7.58-7.51(m,1H ),6.81(d,1H),6.74-6.68(m,1H),6.57(s,1H),3.39(s,3H).LC-MS(m / z,ESI):494.15(M+H) + .

[1096] Example 17: Preparation of Compound 93.15

[1097]

[1098] 0.30 g (0.71 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 25 ml single-mouth round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 0.14 g (1.42 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 0.08 g (0.73 mmol) of 2-hydrazinopyrimidine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 0.16 g of white solid. 1 HNMR(600MHz,Chloroform-d)δ8.20(d,2H),8.11(s,1H),7.99(d,1H),7.92(s,1H), 7.34(d,1H),6.67(t,1H),6.30(s,1H),3.52(s,3H).LC-MS(m / z,ESI):495.03(M+H) + .

[1099] Example 18: Preparation of Compound 93.22

[1100]

[1101] 0.30 g (0.71 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 25 ml single-mouth round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 0.14 g (1.42 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 0.06 g (0.81 mmol) of acetylhydrazine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 0.12 g of white solid. 1 HNMR (600 MHz, DMSO-d 6 )δ10.22-9.94(m,2H),8.15(d,1H),7.94(d,1H),6.59(s,1H),3.41(s,3H),1.69(s,3H).LC-MS(m / z,ESI):459.10(M+H) + .

[1102] With reference to the preparation of compound 93.22 in Example 18, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[1103] Compound 93.25:

[1104]

[1105] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ10.10(s,1H),10.04(s,1H),8.14(d,1H),7.95(d,1H),6.59(s,1H),3. 41(s,3H),2.29-2.20(m,1H),0.87(t,6H).LC-MS(m / z,ESI):487.12(M+H) + .

[1106] Compound 93.34:

[1107]

[1108] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ10.17(s,1H),9.42(d,1H),8.15(d,1H),7.96(d,1H),6.58(s,1H),3.56-3.37(m,6H).LC-MS(m / z,ESI):475.03(M+H)+ .

[1109] Compound 93.35:

[1110]

[1111] White solid. 1 H NMR(600MHz,Chloroform-d)δ8.01(d,1H),7.48(d,1H),7.17(s,1H),6.75(s,1H), 6.36(s,1H),4.03(q,2H),3.56(s,3H),1.15(t,3H).LC-MS(m / z,ESI):489.04(M+H) + .

[1112] Compound 93.53:

[1113]

[1114] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ10.23(s,1H),10.17(s,1H),8.16(d,1H),7.96(d,1H),6.60(s,1H),3.76(s,2H),3.41(s,3H),3.18(s,3H).LC-MS(m / z,ESI):489.04(M+H) + .

[1115] Example 19: Preparation of Compound 101.1

[1116]

[1117] 0.30 g (0.71 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 25 ml single-mouth round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 0.14 g (1.42 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 0.10 g (0.85 mmol) of tetrahydrothiopyran-4-amine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 0.22 g of white solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.30(d,1H),8.23(d,1H),8.00(d,1H),6.62(s,1H),3.43(s,3H),3.15-3.03(m,1H),2.64-2.5 8(m,2H),2.55-2.48(m,2H),1.92-1.85(m,2H),1.63-1.54(m,2H).LC-MS(m / z,ESI):502.16(M+H) + .

[1118] Example 20: Preparation of Compound 101.3

[1119]

[1120] Compound 101.1 (0.30 g, 0.60 mmol) was placed in a 25 ml single-mouth round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, the reaction solution was cooled to 0 degrees Celsius. At this temperature, 0.31 g (1.79 mmol) of m-chloroperbenzoic acid was added to the reaction system, and the reaction was carried out at room temperature for 3 hours. After TLC detected that the reaction was complete, it was extracted with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 0.16 g of a white solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.45(d,1H),8.24(d,1H),8.03(d,1H),6.63(s,1H),3.59-3.51(m,1H),3.43(s,3H), 3.24-3.14(m,2H),3.11-3.04(m,2H),2.03-1.94(m,4H).LC-MS(m / z,ESI):533.86(M+H) + .

[1121] Example 21: Preparation of Compound 105.16 and Compound 105.35

[1122]

[1123] 1) Preparation of tert-butyl (2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)piperidin-4-yl)carbamate (Compound 105.35)

[1124] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction bottle, followed by 6.14 g (28.6 mmol) of 4-tert-butyloxycarbonylaminopiperidine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 12.74 g of white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.02(d,1H),6.91(d,1H),6.60(s,1H),3.60-3.56(m,2H),3.41(s,3H),2 .92-2.87(m,2H),1.83-1.70(m,2H),1.44-1.34(m,12H).LC-MS(m / z,ESI):607.10(M+Na) + .

[1125] 2) Preparation of 3-(5-(4-aminopiperidin-1-yl)sulfonyl)-4-chloro-2-fluorophenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride

[1126] 12.63 g of tert-butyl (2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)piperidin-4-yl)carbamate (Compound 105.35) was placed in a 250 ml single-mouth round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[1127] 3) Preparation of compound 105.16

[1128] 0.30 g (0.58 mmol) of 3-(5-(4-aminopiperidin-1-yl)sulfonyl)-4-chloro-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione hydrochloride was placed in a 25 mL round-bottom flask, and 10 mL of dichloromethane was added for dissolution and dilution. After it was completely dissolved, 0.12 g (1.18 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 60 mg (0.76 mmol) of acetyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 h. The reaction was monitored by TLC and was found to be complete. The reaction solution was extracted with water and dichloromethane, concentrated by evaporation, and purified by column chromatography to obtain 0.10 g of a white solid. 1 H NMR(600MHz,DMSO-d 6 )δ8.23(d,1H),8.05(d,1H),7.87(d,1H),6.63(s,1H),3.76-3.67(m,1H),3.64-3.57(m,2H),3.43(s,3H),3.01-2.93(m,2H),1.84-1.76(m,5H),1.42-1.33(m,2H).LC-MS(m / z,ESI):527.01(M+H) + 。

[1129] Referring to the preparation of Compound 105.16 in Example 21, the physical and chemical properties, NMR data, and mass spectrometry data of some compounds of the present invention are as follows:

[1130] Compound 105.19:

[1131]

[1132] White solid. 1 HNMR(600MHz,DMSO-d 6 )δ8.23(d,1H),8.05(d,1H),7.72(d,1H),6.63(s,1H),3.75-3.67(m,1H),3.66-3.58(m,2H),3.43(s,3H),3.01-2.93(m,2H),2.36-2.27(m,1H),1.83-1.74(m,2H),1.45-1.34(m,2H),0.98(d,6H).LC-MS(m / z,ESI):555.25(M+H) + .

[1133] Compound 105.28:

[1134]

[1135] White solid.1 HNMR (600 MHz, DMSO-d 6 )δ8.21(d,1H),8.04(d,1H),7.25(d,1H),6.63(s,1H),3.64-3.58(m,2H),3.55-3.45(m,4H),3.4 3(s,3H),3.00-2.91(m,2H),1.85-1.78(m,2H),1.46-1.36(m,2H).LC-MS(m / z,ESI):543.08(M+H) + .

[1136] Compound 105.29:

[1137]

[1138] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.04(d,1H),7.21(d,1H),6.62(s,1H),4.00-3.93(m,2H),3.62-3.57(m,2H),3.52-3.44(m,1H),3 .43(s,3H),3.00-2.90(m,2H),1.83-1.78(m,2H),1.44-1.37(m,2H),1.15(t,3H).LC-MS(m / z,ESI):557.26(M+H) + .

[1139] Example 22: Preparation of Compound 109.1 and Compound 109.35

[1140]

[1141] 1) Preparation of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)piperazine-1-carboxylate (Compound 109.35)

[1142] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction flask, followed by 5.33 g (28.6 mmol) of 1-tert-butyloxycarbonylpiperazine, and stirring was started. The mixture was reacted in an ice bath for 0.5 hour. The reaction was completed by TLC detection. The mixture was extracted with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 12.02 g of a white solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.05(d,1H),6.63(s,1H),3.43(s,3H),3.42-3.37(m,4H),3.21-3.16(m,4H),1.39(s,9H).LC-MS(m / z,ESI):593.09(M+Na) + .

[1143] 2) Preparation of 3-(4-chloro-2-fluoro-5-piperazin-1-ylsulfonyl)phenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride

[1144] 12.02 g of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)piperazine-1-carboxylate (Compound 109.35) was placed in a 250 ml single-mouth round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[1145] 3) Preparation of Compound 109.1

[1146] 0.30 g (0.58 mmol) of 3-(4-chloro-2-fluoro-5-piperazin-1-ylsulfonyl)phenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.18 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 63 mg (0.65 mmol) of methyl bromoacetate was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.18 g of a white solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.06(d,1H),6.63(s,1H),3.61(s,3H),3.43(s,3H),3.32-3.2 9(m,2H),3.23-3.17(m,4H),2.64-2.58(m,4H).LC-MS(m / z,ESI):543.15(M+H) + .

[1147] Example 23: Preparation of Compound 109.3

[1148]

[1149] 1) Preparation of 3-(4-chloro-2-fluoro-5-piperazin-1-ylsulfonyl)phenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride

[1150] 12.02 g of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)piperazine-1-carboxylate (Compound 109.35) was placed in a 250 ml single-mouth round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[1151] 2) Preparation of compound 109.3

[1152] 0.30 g (0.58 mmol) of 3-(4-chloro-2-fluoro-5-piperazin-1-ylsulfonyl)phenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.18 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 65 mg (0.65 mmol) of methyl 2-bromopropionate was added to the reaction system, stirred at room temperature, and reacted for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.18 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.19(d,1H),8.05(d,1H),6.61(s,1H),3.61(s,3H),3.43-3.38(m,4H),3.2 1-3.13(m,4H),2.68-2.54(m,4H),1.17(d,3H).LC-MS(m / z,ESI):557.26(M+H) + .

[1153] Example 24: Preparation of Compound 109.16

[1154]

[1155] 1) Preparation of 3-(4-chloro-2-fluoro-5-piperazin-1-ylsulfonyl)phenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride

[1156] 12.02 g of tert-butyl 4-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)piperazine-1-carboxylate (Compound 109.35) was placed in a 250 ml single-mouth round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[1157] 2) Preparation of compound 109.16

[1158] 0.30 g (0.58 mmol) of 3-(4-chloro-2-fluoro-5-piperazin-1-ylsulfonyl)phenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride was placed in a 25 mL round-bottom flask, dissolved and diluted with 10 mL of dichloromethane. After it was completely dissolved, 0.12 g (1.18 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 55 mg (0.70 mmol) of acetyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 h. The reaction was monitored by TLC and was found to be complete. The reaction solution was extracted with water and dichloromethane, concentrated by evaporation, and purified by column chromatography to obtain 0.18 g of a white solid. 1 H NMR(600MHz,DMSO-d 6 )δ8.23(d,1H),8.06(d,1H),6.63(s,1H),3.57-3.49(m,4H),3.43(s,3H),3.27-3.22(m,2H),3.20-3.14(m,2H),2.00(s,3H).LC-MS(m / z,ESI):513.00(M+H) + .

[1159] Referring to the preparation of Compound 109.16 in Example 24, the physical and chemical properties, NMR data, and mass spectrometry data of some compounds of the present invention are as follows:

[1160] Compound 109.28:

[1161]

[1162] White solid. 1 HNMR(600MHz,DMSO-d 6 )δ8.20(d,1H),8.05(d,1H),6.62(s,1H),3.60(s,3H),3.49-3.39(m,7H),3.27-3.17(m,4H).LC-MS(m / z,ESI):529.23(M+H) + .

[1163] Compound 109.29:

[1164]

[1165] White solid. 1 HNMR(600MHz,DMSO-d 6)δ8.20(d,1H),8.05(d,1H),6.63(s,1H),4.04(q,2H),3.49-3.44(m,4H),3 .43(s,3H),3.25-3.19(m,4H),1.17(t,3H).LC-MS(m / z,ESI):543.24(M+H) + .

[1166] Compound 109.30:

[1167]

[1168] White solid. 1 HNMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.05(d,1H),6.63(s,1H),3.97-3.92(m,2H),3.50-3.43(m,4H),3.43(s ,3H),3.25-3.18(m,4H),1.61-1.53(m,2H),0.88(t,3H).LC-MS(m / z,ESI):557.19(M+H) + .

[1169] Compound 109.32:

[1170]

[1171] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.20(d,1H),8.05(d,1H),6.63(s,1H),4.03-3.95(m,2H),3.50-3.44(m,4H),3.43(s,3H),3.2 5-3.18(m,4H),1.57-1.50(m,2H),1.35-1.30(m,2H),0.89(t,3H).LC-MS(m / z,ESI):571.27(M+H) + .

[1172] Example 25: Preparation of Compounds 111.16 and 111.35

[1173]

[1174] 1) Preparation of tert-butyl (2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)azetidine-3-carbamate (Compound 111.35)

[1175] 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride was placed in a 250 ml single-mouth round-bottom flask, and 100 ml of dichloromethane was added to dissolve and dilute. After the raw material was completely dissolved, 4.82 g (47.6 mmol) of triethylamine was added dropwise to the above reaction bottle, followed by 4.93 g (28.6 mmol) of 3-N-tert-butyloxycarbonylaminocyclobutylamine, stirring was started, and the reaction was carried out in an ice bath for 0.5 hours. TLC detected that the reaction was complete. Extraction was carried out with water and dichloromethane, and the organic phase was retained, dried with anhydrous magnesium sulfate, desolventized and concentrated to obtain 11.78 g of white solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.88(s,1H),8.21(d,1H),8.03(d,1H),6.61(s,1H),4.09-4.03(m,1H),3.98-3.82 (m,2H),3.73-3.54(m,2H),3.42(s,3H),1.35(s,9H).LC-MS(m / z,ESI):557.11(M+H) + .

[1176] 2) Preparation of 3-(5-(3-aminoazetidin-1-yl)sulfonyl)-4-chloro-2-fluorophenyl)-1-methyl-6-trifluoromethylpyrimidine-2,4(1H,3H)-dione hydrochloride

[1177] 11.78 g of (2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonyl)azetidine-3-carbamic acid tert-butyl ester (Compound 111.35) was placed in a 250 ml single-mouth round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After 1 hour of reaction, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of light yellow colloidal solid was obtained.

[1178] 3) Preparation of compound 111.16

[1179] Take 0.30 g (0.58 mmol) of 3-(5-(3-azetidin-1-ylsulfonyl)-4-chloro-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione hydrochloride and place it in a 25 mL round-bottom flask. Add 10 mL of dichloromethane to dissolve and dilute it. After it is completely dissolved, add 0.12 g (1.18 mmol) of triethylamine dropwise to the above reaction flask. After the addition is complete, add 53 mg (0.68 mmol) of acetyl chloride to the reaction system, stir at room temperature for 0.5 h, monitor the reaction by TLC until it is complete. Extract the reaction solution with water and dichloromethane, remove the solvent by concentration, and purify it by column chromatography to obtain 0.07 g of a white solid. 1 H NMR(600MHz,DMSO-d 6 )δ8.55(d,1H),8.24(d,1H),8.08(d,1H),6.62(s,1H),4.50 - 4.41(m,1H),4.17 - 4.09(m,2H),3.90 - 3.82(m,2H),3.43(s,3H),1.82(s,3H).LC-MS(m / z,ESI):499.14(M + H) + .

[1180] Example 26: Preparation of Compounds 115.16 and 115.35

[1181]

[1182] 1) Preparation of tert-butyl (3-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)phenyl)sulfonyl)azetidine-1-carboxylate (Compound 115.35)

[1183] Place 10.00 g (23.8 mmol) of 2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1-(2H)-yl)benzenesulfonyl chloride in a 250 mL single-neck round-bottom flask, add 100 mL of dichloromethane to dissolve and dilute it. After the raw material is completely dissolved, add 4.82 g (47.6 mmol) of triethylamine dropwise to the above reaction flask, and then add 4.93 g (28.6 mmol) of 1-(tert-butoxycarbonyl)-3-aminocyclobutane. Start stirring and react in an ice bath for 0.5 h. Monitor the reaction by TLC until it is complete. Extract with water and dichloromethane, retain the organic phase, dry with anhydrous magnesium sulfate, remove the solvent by concentration, and obtain 11.78 g of a white solid. 1 H NMR(600MHz,DMSO-d 6)δ8.20(d,1H),8.06(d,1H),7.63(d,1H),6.61(s,1H),4.34-4.23(m,1H),4.08-4.05 (m,2H),3.88-3.84(m,2H),3.42(s,3H),1.37(s,9H).LC-MS(m / z,ESI):557.21(M+H) + .

[1184] 2) Preparation of N-azetidin-3-yl-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride

[1185] 11.78 g of (3-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidine-1(2H)-phenyl)sulfonamido)azetidine-1-carboxylic acid tert-butyl ester (Compound 115.35) was placed in a 250 ml single-mouth round-bottom flask, and 120 ml of dichloromethane was added to dissolve. After complete dissolution, 36% hydrochloric acid was added dropwise with a dropping funnel, stirred at room temperature, and the reaction was monitored by TLC. After reacting for 1 hour, TLC showed that it was completely converted into hydrochloride, and the reaction was stopped. Extraction, retaining the aqueous phase, desolventizing and concentrating, 9.54 g of a light yellow colloidal solid was obtained.

[1186] 3) Preparation of compound 115.16

[1187] 0.30 g (0.58 mmol) of N-azetidin-3-yl-2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)benzenesulfonamide hydrochloride was placed in a 25 ml round-bottom flask, and 10 ml of dichloromethane was added to dissolve and dilute. After it was completely dissolved, 0.12 g (1.18 mmol) of triethylamine was added dropwise to the above reaction flask. After the addition was complete, 53 mg (0.68 mmol) of acetyl chloride was added to the reaction system, and the mixture was stirred at room temperature for 0.5 hour. The reaction was completed after TLC monitoring. The reaction solution was extracted with water and dichloromethane, desolventized and concentrated, and separated and purified by column chromatography to obtain 0.07 g of a white solid. 1 H NMR (600 MHz, DMSO-d 6)δ8.92(d,1H),8.23(d,1H),8.04(d,1H),6.62(d,1H),4.27-4.20(m,1H),4.13-4.06(m,1H),3 .96-3.86(m,2H),3.64-3.56(m,1H),3.43(s,3H),1.71(s,3H).LC-MS(m / z,ESI):498.99(M+H) + .

[1188] With reference to the preparation of compound 115.16 in Example 26, the physicochemical properties, NMR data and mass spectrometry data of some compounds of the present invention are as follows:

[1189] Compound 115.28:

[1190]

[1191] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.90(d,1H),8.22(d,1H),8.04(d,1H),6.62(s,1H),4.13-4.07(m,1H),4.04-3.94 (m,2H),3.74-3.64(m,2H),3.53(s,3H),3.42(s,3H).LC-MS(m / z,ESI):537.12(M+Na) + .

[1192] Compound 115.29:

[1193]

[1194] White solid. 1 H NMR (600 MHz, DMSO-d 6 )δ8.89(d,1H),8.21(d,1H),8.03(d,1H),6.61(s,1H),4.11-4.07(m,1H),4.00-3.95 (m,4H),3.73-3.59(m,2H),3.42(s,3H),1.13(t,3H).LC-MS(m / z,ESI):551.19(M+Na) + .

[1195] Biological activity assay

[1196] Example 27: Indoor herbicidal activity assay

[1197] The herbicidal activity test method of the compounds of the present invention is as follows:

[1198] A certain amount of seeds of grass weeds (barnyard grass, golden foxtail) and broadleaf weeds (zinnia, velvetleaf) were sown in paper cups with a diameter of 7 cm filled with nutrient soil, covered with 1 cm of soil after sowing, suppressed and watered, and cultured in a greenhouse according to conventional methods. The grass weeds grew to the 2-3 leaf stage and the broadleaf weeds grew to the 2-4 leaf stage. The stems and leaves were sprayed according to the designed dosage of the experiment on a crawler crop sprayer (designed and produced by EngineerResearch Ltd., UK) (spray pressure 1.95 kg / cm 2 , spray volume 500L / hm 2 , crawler speed 1.48km / h). The test was repeated 3 times. After the test materials were treated, they were placed in the operation hall. After the liquid was naturally dried in the shade, they were placed in the greenhouse and managed according to the conventional method. The reaction of the weeds to the agent was observed and recorded. After treatment, the control effect of the test agent on weeds was visually inspected regularly. The control effect grading standard: 0 is ineffective, 100% is completely killed or severely suppressed.

[1199] The herbicidal activity test results of the compounds of the present invention are as follows:

[1200] 9.375g ai / hm 2Compounds 1.1, 1.2, 1.3, 1.4, 1.5, 1.8, 1.9, 1.10, 1.11, 1.13, 1.14, 1.20, 1.21, 1.24, 1.28, 1.32, 1.37, 1.40, 1.43, 1.46, 1.355, 1.363, 1.379, 1.397, 1.403, 2.2, 2.4, 3.2, 3.4, 3.20, 4.2, 4.4, 29.1, 29.2, 29.3, 29.4, 29.5, 29.8, 29.9, 29.10, 29.11, 29.20, 29.21, 29.28, 29 .43, 29.46, 29.355, 29.363, 29.379, 29.397, 29.403, 57.1, 57.2, 57.3, 57.4, 57.5, 57.9, 57.10, 57.20, 57.21, 57.43, 57.363, 57.397, 57.403, 85.1, 85.7, 85.12, 85.16, 85.17, 85.18, 85.19, 85.24, 85.25, 85.26, 85.28, 85.29, 85.35, 85.36, 85.55, 85.56, 85.57, 85.5 8, 85.59, 85.60, 85.61, 85.62, 85.63, 85.64, 85.378, 89.1, 89.7, 89.11, 89.12, 89.14, 89.16, 89.17, 89.18, 89.19, 89.24, 89.25, 86.26, 89.28, 89.35, 89.36, 89.43, 89.47, 89.54, 89.55, 89.57, 89.58, 89.59, 89.60, 89.61, 89.62, 89.63, 89.64, 89.370, 89.371, 89.37 2. The control efficiency of 89.378, 89.394, 89.418, 93.12, 93.15, 93.22, 93.25, 93.34, 93.35, 93.53, 101.1, 101.3, 105.16, 105.19, 105.28, 105.29, 105.35, 109.1, 109.3, 109.16, 109.28, 109.29, 109.30, 109.32, 109.35, 111.16, 111.35, 115.16, 115.28, 115.29 and 115.35 against zinnia and velvetleaf is not less than 80%.

[1201] 37.5g ai / hm 2Compounds 1.1, 1.2, 1.3, 1.4, 1.5, 1.8, 1.9, 1.10, 1.11, 1.13, 1.14, 1.20, 1.21, 1.24, 1.28, 1.32, 1.37, 1.40, 1.43, 1.46, 1.355, 1.363, 1.379, 1.397, 1.403, 2.2, 2.4, 3.2, 3.4, 3.20, 4.2, 4.4, 29.1, 29.2, 29.3, 29.4, 29.5, 29.8, 29.9, 29.10, 29.11, 29.20, 29.21, 29.28, 29 .43, 29.46, 29.355, 29.363, 29.379, 29.397, 29.403, 57.1, 57.2, 57.3, 57.4, 57.5, 57.9, 57.10, 57.20, 57.21, 57.43, 57.363, 57.397, 57.403, 85.1, 85.7, 85.12, 85.16, 85.17, 85.18, 85.19, 85.24, 85.25, 85.26, 85.28, 85.29, 85.35, 85.36, 85.55, 85.56, 85.57, 85.58 , 85.59, 85.60, 85.61, 85.62, 85.63, 85.64, 85.378, 89.1, 89.7, 89.11, 89.12, 89.14, 89.16, 89.17, 89.18, 89.19, 89.24, 89.25, 86.26, 89.28, 89.35, 89.36, 89.43, 89.47, 89.54, 89.55, 89.57, 89.58, 89.59, 89.60, 89.61, 89.62, 89.63, 89.64, 89.370, 89.371, 89.372, The control efficiency of 89.378, 89.394, 89.418, 93.12, 93.15, 93.22, 93.25, 93.34, 93.35, 93.53, 101.1, 101.3, 105.16, 105.19, 105.28, 105.29, 105.35, 109.1, 109.3, 109.16, 109.28, 109.29, 109.30, 109.32, 109.35, 111.16, 111.35, 115.16, 115.28, 115.29 and 115.35 against golden foxtail grass and barnyard grass is not less than 80%.

Claims

1. A sulfonyl-containing uracil compound, characterized in that: The compound is shown in general formula I: In the general formula I: Y is selected from Y 1 -Y 11 One of the groups shown: R 1 , R 2 Each is independently selected from hydrogen, halogen, nitro, amino, cyano, C1-C6 alkyl or halogenated C1-C6 alkyl; R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 Each is independently selected from hydrogen, C1-C6 alkyl or halogenated C1-C6 alkyl; X 1 , X 2 , X 3 , X 4 , X 5 , X 6 are each independently selected from hydrogen, halogen, cyano, C1-C6 alkyl, halogenated C1-C6 alkyl; or, X 1 With X 2 together form a C3-C8 cycloalkyl group; or, X 3 With X 4 together form a C3-C8 cycloalkyl group; or, X 5 With X 6 Together they form a C3-C8 cycloalkyl group; n is selected from 0, 1 or 2; Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , Q 7 , Q 8 , Q 9 , Q 10 Each is independently selected from hydrogen, C1-C6 alkyl, halogenated C1-C6 alkyl, cyano C1-C6 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl C1-C6 alkyl, allyl, propargyl, C1-C6 alkylcarbonyl, halogenated C1-C6 alkylcarbonyl, C3-C8 cycloalkylcarbonyl, C1-C6 alkoxycarbonyl, C2-C8 alkenylcarbonyl, C2-C8 alkynylcarbonyl, C1-C6 alkoxy C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl C1-C6 alkyl, C1-C6 alkylsulfonyl, halogenated C1-C6 alkylsulfonyl, C3-C8 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C6 alkyl, halogenated C1-C6 alkyl, C1-C6 alkoxy, halogenated C1-C6 alkoxy, C1-C6 alkylthio or halogenated C1-C6 alkylthio; or a stereoisomer of the compound of formula I; or a salt of a compound of formula I; or a salt of a stereoisomer of a compound of formula I.

2. The compound according to claim 1, characterized in that In the general formula I: Y is selected from Y 1 -Y 11 One of the groups shown; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 Each is independently selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; X 1 , X 2 , X 3 , X 4 , X 5 , X 6 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, halogenated C1-C4 alkyl; or, X 1 With X 2 together form a C3-C6 cycloalkyl group; or, X 3 With X 4 together form a C3-C6 cycloalkyl group; or, X 5 With X 6 Together they form a C3-C6 cycloalkyl group; n is selected from 0, 1 or 2; Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , Q 7 , Q 8 , Q 9 , Q 10 Each is independently selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C3 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C3 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C3 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

3. The compound according to claim 2, characterized in that In the general formula I: Y is selected from Y 1 -Y 11 One of the groups shown; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 Each is independently selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; X 1 , X 2 , X 3 , X 4 , X 5 , X 6 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, halogenated C1-C4 alkyl; or, X 1 With X 2 together form a C3-C6 cycloalkyl group; or, X 3 With X 4 together form a C3-C6 cycloalkyl group; or, X 5 With X 6 Together they form a C3-C6 cycloalkyl group; n is selected from 0, 1 or 2; Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , Q 7 , Q 8 , Q 9 , Q 10 Each is independently selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

4. The compound according to any one of claims 1 to 3, characterized in that In the general formula I: Y is selected from Y 1 -Y 11 One of the groups shown; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 each independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; X 1 , X 2 , X 3 , X 4 , X 5 , X 6 are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 1 With X 2 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; or, X 3 With X 4 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; or, X 5 With X 6 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; n is selected from 0, 1 or 2; Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , Q 6 , Q 7 , Q 8 , Q 9 , Q 10 each independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, Cyclopentylpropyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl , cyclohexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl , t-Butylcarbonyl, t-Butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, t-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

5. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 1 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 3 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; X 1 , X 2 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, halogenated C1-C4 alkyl; or, X 1 With X 2 Together they form a C3-C6 cycloalkyl group; Q 1 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

6. The compound according to claim 5, characterized in that In the general formula I: Y is selected from Y 1 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 3 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; X 1 , X 2 are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 1 With X 2 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; Q 1 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

7. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 2 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 4 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; X 3 , X 4 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, halogenated C1-C4 alkyl; or, X 3 With X 4 Together they form a C3-C6 cycloalkyl group; Q 2 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

8. The compound according to claim 7, characterized in that In the general formula I: Y is selected from Y 2 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 4 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; X 3 , X 4 are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 3 With X 4 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; Q 2 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

9. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 3 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 5 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; X 5 , X 6 are each independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, halogenated C1-C4 alkyl; or, X 5 With X 6 Together they form a C3-C6 cycloalkyl group; Q 3 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

10. The compound according to claim 9, characterized in that In the general formula I: Y is selected from Y 3 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 5 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; X 5 , X 6 are each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; or, X 5 With X 6 together form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; Q 3 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

11. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 4 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 6 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; Q 4 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

12. The compound according to claim 11, characterized in that In the general formula I: Y is selected from Y 4 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 6 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; Q 4 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

13. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 5 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 7 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; Q 5 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

14. The compound according to claim 13, characterized in that In the general formula I: Y is selected from Y 5 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 7 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; Q 5 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

15. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 6 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 8 , R 9 Each is independently selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; Q 6 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

16. The compound according to claim 15, characterized in that In the general formula I: Y is selected from Y 6 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 8 , R 9 each independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; Q 6 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

17. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 7 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 10 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; n is selected from 0, 1 or 2; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

18. The compound according to claim 17, characterized in that In the general formula I: Y is selected from Y 7 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 10 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; n is selected from 0, 1 or 2; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

19. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 8 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 11 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; Q 7 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

20. The compound according to claim 19, characterized in that In the general formula I: Y is selected from Y 8 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 11 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; Q 7 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

21. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 9 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; Q 8 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

22. The compound according to claim 21, characterized in that In the general formula I: Y is selected from Y 9 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; Q 8 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

23. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 10 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 12 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; Q 9 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

24. The compound according to claim 23, characterized in that In the general formula I: Y is selected from Y 10 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 12 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; Q 9 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

25. The compound according to claim 3, characterized in that In the general formula I: Y is selected from Y 11 ; R 1 , R 2 Each is independently selected from hydrogen, halogen, C1-C4 alkyl or halogenated C1-C4 alkyl; R 13 Selected from hydrogen, C1-C4 alkyl or halogenated C1-C4 alkyl; Q 10 is selected from hydrogen, C1-C4 alkyl, halogenated C1-C4 alkyl, cyano C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl C1-C4 alkyl, allyl, propargyl, C1-C4 alkylcarbonyl, halogenated C1-C4 alkylcarbonyl, C3-C6 cycloalkylcarbonyl, C1-C4 alkoxycarbonyl, C2-C4 alkenylcarbonyl, C2-C4 alkynylcarbonyl, C1-C4 alkoxy C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkylcarbonyl, C1-C4 alkoxycarbonyl C1-C2 alkyl, C1-C4 alkylsulfonyl, halogenated C1-C4 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 Each is independently selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, halogenated C1-C4 alkoxy, C1-C4 alkylthio or halogenated C1-C4 alkylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

26. The compound according to claim 25, characterized in that In the general formula I: Y is selected from Y 10 ; R 1 , R 2 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; R 13 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl or perfluoroethyl; Q 10 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, cyanomethyl, cyanoethyl, cyanopropyl, cyanobutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclopropylbutyl, cyclobutylmethyl, cyclobutylethyl, cyclobutylpropyl, cyclobutylbutyl, cyclopentylmethyl, cyclopentylethyl, cyclopentylbutyl Propyl, cyclopentylbutyl, cyclohexylmethyl, cyclohexylethyl, cyclohexylpropyl, cyclohexylbutyl, allyl, propargyl, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, isopropylcarbonyl, n-butylcarbonyl, isobutylcarbonyl, sec-butylcarbonyl, tert-butylcarbonyl, monochloromethylcarbonyl, dichloromethylcarbonyl, trichloromethylcarbonyl, monobromomethylcarbonyl, dibromomethylcarbonyl, tribromomethylcarbonyl, monofluoromethylcarbonyl, difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, heptafluoroisopropylcarbonyl, perfluoroethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentylcarbonyl, cyclo hexylcarbonyl, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, vinylcarbonyl, acetylenecarbonyl, methoxymethylcarbonyl, ethoxymethylcarbonyl, n-propoxymethylcarbonyl, isopropoxymethylcarbonyl, n-butoxymethylcarbonyl, isobutoxymethylcarbonyl, sec-butoxymethylcarbonyl, tert-butoxymethylcarbonyl, methoxyethylcarbonyl, ethoxyethylcarbonyl, n-propoxyethylcarbonyl, isopropoxyethylcarbonyl, n-butoxyethylcarbonyl, isobutoxyethylcarbonyl, sec-butoxyethyl carbonyl, tert-butoxyethylcarbonyl, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, monochloromethylsulfonyl, dichloromethylsulfonyl, trichloromethylsulfonyl, monobromomethylsulfonyl, dibromomethylsulfonyl, tribromomethylsulfonyl, monofluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, heptafluoroisopropylsulfonyl, perfluoroethylsulfonyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, W 1 , W 2 , W 3 , W 4 , W 5 each independently selected from hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, amino, carboxyl, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, monochloromethyl, dichloromethyl, trichloromethyl, monobromomethyl, dibromomethyl, tribromomethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, heptafluoroisopropyl, perfluoroethyl, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, ethylthio, trifluoromethylthio or 2,2,2-trifluoroethylthio; or a stereoisomer of the compound of formula I; or a salt formed by a compound of formula I and hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid; or a salt formed by a stereoisomer of a compound of formula I with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, propionic acid, butyric acid, valeric acid, trifluoroacetic acid, oxalic acid, malonic acid, methanesulfonic acid, 4-toluenesulfonic acid, malic acid, fumaric acid, lactic acid, maleic acid, salicylic acid, tartaric acid or citric acid.

27. Use of the compound of general formula I or a salt thereof, or a stereoisomer of the compound of general formula I or a salt thereof according to claim 1 for controlling weeds.

28. A herbicidal composition, characterized in that: The compound of general formula I or its salt, or the stereoisomer of the compound of general formula I or its salt as claimed in claim 1 is used as the active component, and the weight percentage of the active component in the composition is 0.1-99%.

29. Use of the herbicidal composition according to claim 28 for controlling weeds.

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