Ake monkey head and coil fixing device and magnetic resonance imaging system

Abstract

The invention relates to the technical field of magnetic resonance imaging systems, in particular to a sober monkey head and coil fixing device and a magnetic resonance imaging system.The sober monkey head and coil fixing device comprises a monkey box used for containing a monkey body, one end face of the monkey box is an upward inclined face, and a head hole used for exposing a monkey head is formed in the middle of the inclined face; the neck positioning module, the left-right positioning module, the upper end positioning module and the lower end positioning module are arranged on the outer surface of the monkey box. By means of the arrangement, the problems that a fixing device in an existing magnetic resonance imaging system is difficult to fix the head of a sober macaque, and the sober macaque is prone to restlessness are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of magnetic resonance imaging systems, and in particular to a head and coil fixing device for a conscious monkey and a magnetic resonance imaging system. Background Art

[0002] At present, with the increasing number of global brain disease patients year by year, the research on the mechanism and treatment plan of brain diseases is extremely urgent. An ideal animal model is one of the important research conditions for the study of the mechanism of brain diseases and drug development. Non-human primates such as macaques are highly similar to humans in many aspects such as brain structure, physiological activities, and ethology, and can complete cognitive and social tasks similar to humans, making them the most ideal model for studying brain diseases.

[0003] Magnetic resonance imaging is one of the important scientific means for studying brain function and brain diseases. At present, the magnetic resonance imaging experiments on anesthetized experimental monkeys have been relatively mature. However, anesthetics have a certain impact on the nervous system activities of experimental monkeys, resulting in the experimental data obtained under the anesthetized state not being able to fully and truly reflect the activities and functions of the experimental monkey's brain. Therefore, the magnetic resonance imaging research on conscious monkeys is imperative. And the fixing devices in the existing magnetic resonance imaging systems are difficult to fix the heads of conscious macaques. Conscious macaques are prone to restlessness, which will lead to unclear final imaging and increase the difficulty of research. Summary of the Invention

[0004] In order to solve the problem that the fixing device in the existing magnetic resonance imaging system is difficult to fix the head of a conscious macaque and the conscious macaque is prone to restlessness, the present invention proposes a head and coil fixing device for a conscious monkey and a magnetic resonance imaging system.

[0005] The technical solution adopted by the present invention is that a head and coil fixing device for a conscious monkey includes a monkey box for accommodating the monkey body. One end face of the monkey box is an upward inclined plane, and a head hole for the monkey head to expose is opened in the middle of the inclined plane. It also includes: a neck positioning module respectively arranged on the outer surface of the monkey box, which includes a pair of neck plates that can approach or move away from each other. The pair of neck plates can jointly form a neck ring that restricts the monkey's neck, and the neck ring is located in the head hole; a left and right positioning module, which includes a pair of fixing components arranged on the left and right sides of the head hole. The pair of fixing components can approach or move away from each other towards the head hole and can drive the coil to approach or move away from the head hole; an upper end positioning module, which is arranged at the upper end of the head hole. The upper end positioning module can approach or move away from the head hole and can drive the coil to approach or move away from the head hole; a lower end positioning module, which is arranged at the lower end of the head hole. The lower end positioning module can approach or move away from the head hole.

[0006] Preferably, the fixing assembly includes a first slider disposed on the monkey cage, an ear rod inserted into the first slider, and an ear rod fixing member. The ear rod can slide within the first slider and move closer to or away from the head hole, and the ear rod fixing member is used to fix the ear rod on the first slider.

[0007] Preferably, an ear cup is detachably fixed to one end of the ear rod close to the head hole, and an earplug is provided at one end of the ear cup close to the head hole.

[0008] Preferably, a coil fixing member is provided on the ear rod. The coil can be slidably inserted onto the ear rod and fixed to the ear rod by the coil fixing member.

[0009] Preferably, the upper end positioning module includes a second slider disposed on the monkey cage, a head rod inserted into the second slider, and a head rod fixing member. The head rod can slide within the second slider and move closer to or away from the head hole, and the head rod fixing member is used to fix the head rod on the second slider.

[0010] Preferably, a suction cup for adsorbing the coil is detachably fixed to one end of the head rod close to the head hole.

[0011] Preferably, the lower end positioning module includes a third slider slidably connected to the monkey cage. At least a part of the third slider is disposed at the lower end of the head hole and can slide up and down along the inclined surface.

[0012] Preferably, one end of the part of the third slider at the lower end of the head hole close to the head hole is set to be concave.

[0013] Preferably, the fixing assembly further includes a first fixing member. The first slider is slidably connected to the monkey cage and can slide up and down on the monkey cage. The first fixing member is used to fix the first slider on the monkey cage.

[0014] Preferably, the upper end positioning module further includes a second fixing member. The second slider is slidably connected to the monkey cage and can move closer to or away from the inclined surface. The second fixing member is used to fix the second slider on the monkey cage.

[0015] Preferably, the lower end positioning module further includes a third fixing member. The third fixing member is used to fix the third slider on the monkey cage.

[0016] The present invention also provides a magnetic resonance imaging system, including a coil and the above-mentioned awake monkey head and coil fixing device.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] In the head and coil fixing device for conscious monkeys in the present invention, the monkey body is accommodated in a monkey box, the movement of the neck of the experimental monkey is restricted through a head hole and a pair of neck plates, and the displacement of the head of the experimental monkey in four directions, namely left and right and up and down, is restricted through a left and right positioning module, an upper end positioning module and a lower end positioning module. As a result, it is difficult for the head of the conscious experimental monkey to have a large displacement, ensuring the clarity of the final imaging and reducing the difficulty of the research. In addition, a pair of fixing components and the upper end positioning module can also fix the coil on both sides and the head of the monkey head, so that the coil can cover most areas of the monkey head, and the coverage area of the coil is large. When this fixing device is applied to magnetic resonance imaging, the final imaging effect is good. In addition, when this fixing device is applied to other surgeries such as two-photon (head post installation), it can be adapted to different coils and fix the matching coil on the head of the experimental monkey, with a wide range of applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention will be described in detail below in conjunction with embodiments and drawings, wherein:

[0020] Figure 1 is a schematic structural diagram of the monkey box;

[0021] Figure 2 is a schematic structural diagram of a pair of neck plates;

[0022] Figure 3 is a partial schematic structural diagram of the fixing component;

[0023] Figure 4 is a schematic structural diagram of the ear rod;

[0024] Figure 5 is a schematic structural diagram of the second slider;

[0025] Figure 6 is a schematic structural diagram of the head rod;

[0026] Figure 7 is a schematic structural diagram of the third slider.

[0027] 10. Monkey box; 11. Inclined surface; 12. Head hole; 13. Handle; 14. Operation window; 15. Door panel; 16. First slide bar; 161. First screw hole; 17. Second slide bar; 18. Third slide bar; 19. Neck plate slot;

[0028] 20. Neck plate;

[0029] 30. Fixing component; 31. First slider; 32. Ear rod; 33. Ear cup; 34. Earplug; 35. Ear rod fixing piece; 36. Coil fixing piece; 37. First fixing piece; 38. Ear rod placement hole; 39. First chute;

[0030] 40. Second slider; 41. Head rod; 42. Suction cup; 43. Head rod fixing member; 44. Second fixing member; 45. Head rod placement hole; 46. Second chute;

[0031] 50. Third slider; 51. Third fixing member; 52. Third chute. Detailed implementation

[0032] To make the objectives, technical solutions and advantages of the present invention clearer, the embodiments of the present invention will be further described in detail below in conjunction with the accompanying drawings. Examples of the embodiments are shown in the drawings, where the same or similar reference numerals represent the same or similar components or components with the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are only used to explain the present invention and should not be construed as a limitation to the present invention.

[0033] In one embodiment, as Figure 1 shown, a head and coil fixing device for a conscious monkey includes a monkey box 10 for accommodating the monkey body. One end face of the monkey box 10 is an upward inclined surface 11, and a head hole 12 is opened in the middle of the inclined surface 11. The monkey box 10 is used to accommodate the monkey body, and the head hole 12 is used for the monkey head to protrude. Specifically, a door panel 15 that can be opened and closed may be provided at one end of the monkey box 10 away from the inclined surface 11. The experimental monkey can enter the monkey box 10 through the door panel 15, so as to accommodate the monkey body in the monkey box 10.

[0034] The head and coil fixing device for a conscious monkey further includes a neck positioning module, a left and right positioning module, an upper end positioning module, and a lower end positioning module respectively provided on the outer surface of the monkey box 10. The neck positioning module includes a pair of neck plates 20 that can approach or move away from each other. The pair of neck plates 20 can jointly form a neck ring that restricts the monkey's neck, and the neck ring is located in the head hole 12. The left and right positioning module includes a pair of fixing components 30 provided on the left and right sides of the head hole 12. The pair of fixing components 30 can approach or move away from each other toward the head hole 12. At the same time, the pair of fixing components 30 can drive the coil to approach or move away from the head hole 12. The upper end positioning module is provided at the upper end of the head hole 12. The upper end positioning module can approach or move away from the head hole 12. At the same time, the upper end positioning module can drive the coil to approach or move away from the head hole 12. The lower end positioning module is provided at the lower end of the head hole 12. The lower end positioning module can approach or move away from the head hole 12.

[0035] During operation, open the door panel 15. After the experimental monkey enters, close the door panel 15. The experimental monkey can assume a squatting position in the device. After the head of the experimental monkey protrudes from the head hole 12, first use a pair of neck plates 20 to fix its neck, then use a pair of fixing components 30 to fix the left and right ends of the monkey's head, use the upper end positioning module and the lower end positioning module to fix the upper and lower ends of the monkey's head. At the same time, use a pair of fixing components 30 and the upper end fixing module to fix the coil to cover the monkey's head, and make the coil wrap around the top and both sides of the experimental monkey's head.

[0036] Among them, as Figure 1-2 shown, a neck plate slot 19 can be provided on the inclined surface 11, and a neck plate 20 bar adapted to the neck plate slot 19 is provided on the neck plate 20. During use, first install the lower neck plate 20 onto the inclined surface 11 through the neck plate slot 19. After the experimental monkey's head extends, then insert the upper neck plate 20 to complete the fixation of a pair of neck plates 20 on the neck of the experimental monkey. The positions of the neck plate slot 19 and the neck plate 20 bar can be interchanged. A limiting member can be provided at the lower end of the inclined surface 11. When the lower neck plate 20 slides along the neck plate slot 19 to the limiting member, it is limited by the limiting member. The upper neck plate 20 can be fixed at a position that exactly fixes the neck of the experimental monkey through a fixing knob or the like.

[0037] In the awake monkey head and coil fixing device of this embodiment, the monkey body is accommodated by the monkey box 10, the movement of the neck of the experimental monkey is restricted by the head hole 12 and a pair of neck plates 20, and the displacement of the head of the experimental monkey in the left-right and up-down four directions is restricted by the left-right positioning module, the upper-end positioning module and the lower-end positioning module. As a result, it is difficult for the head of the awake experimental monkey to have a large displacement, ensuring the clarity of the final imaging and reducing the difficulty of the research. In addition, a pair of fixing components 30 and the upper-end positioning module can also fix and cover the coil on the monkey head, and make the coil wrap around the top and both sides of the experimental monkey's head. Thus, the coil can cover most areas of the monkey head, the coverage area of the coil is large, and it fits the scalp. When this fixing device is applied to magnetic resonance imaging, the final imaging effect is good. In addition, when this fixing device is applied to other surgeries such as two-photon (head post installation), it can be adapted to different coils and fix the matching coil on the head of the experimental monkey, with a wide range of applications.

[0038] In one embodiment, handles 13 are provided on both sides of the monkey box 10, and the monkey box 10 can be conveniently transferred by lifting the handles 13, and the experimental monkey in the monkey box 10 can also be conveniently transferred at the same time.

[0039] In one embodiment, operation windows 14 are also provided on both sides of the monkey box 10. The operation windows 14 are made of transparent materials such as glass. The experimental monkey can be observed at any time through the operation windows 14, and other experimental operations can also be carried out using the operation windows.

[0040] In one embodiment, as Figure 3-4As shown in the figure, the fixing component 30 includes a first slider 31, an ear rod 32 and an ear rod fixing member 35. The first slider 31 is arranged on the monkey box 10. The ear rod 32 is inserted into the first slider 31 and can slide within the first slider 31, approaching or moving away from the head hole 12 at the same time. The ear rod fixing member 35 can fix the ear rod 32 on the first slider 31. Specifically, a through ear rod placement hole 38 is opened in the first slider 31 in the direction towards the head hole 12. The ear rod 32 is inserted into the ear rod placement hole 38 of the first slider 31. By manually pushing and pulling one end of the head rod 41 away from the head hole 12, the ear rod 32 can be conveniently driven to approach or move away from the head hole 12. Thus, when a monkey head extends out of the head hole 12, a pair of ear rods 32 on a pair of fixing components 30 can approach and fix the monkey head at the left and right ends of the monkey head, thereby restricting the left - right movement of the monkey head. Among them, the ear rod fixing member 35 can be a bolt. A threaded hole is opened on the first slider 31 perpendicular to the length direction of the ear rod placement hole 38, and the threaded hole communicates with the ear rod placement hole 38. Thus, after the ear rod 32 is adjusted to a suitable position for restricting the monkey head, the bolt is screwed into the threaded hole to press the ear rod 32 against the side wall of the ear rod placement hole 38, realizing the fixation of the ear rod 32, and further realizing the restriction of the left - right displacement of the monkey head by the ear rod 32.

[0041] In other embodiments, the ear rod fixing member 35 can also be a pair of lock nuts, etc. Threads matching the ear rod 32 are opened on the ear rod 32. Thus, when the ear rod 32 reaches a suitable position, the left and right ends of the ear rod 32 can be locked by the lock nuts, so that the ear rod 32 cannot slide in the ear rod placement hole 38, and further realizing the restriction of the left - right displacement of the monkey head by the ear rod 32. The ear rod placement hole 38 can be opened in an incomplete through - hole manner, as long as it is ensured that one end of the ear rod 32 close to the head hole 12 can extend out of the ear rod placement hole 38, and the ear rod 32 can slide in the ear rod placement hole 38 and approach or move away from the head hole 12.

[0042] In one embodiment, three mutually - spaced ear rod placement holes 38 are opened on the first slider 31. The three ear rod placement holes 38 are successively close to the inclined surface 11. The threaded holes on the first slider 31 are respectively perpendicular to the length direction of the three ear rod placement holes 38 (i.e., the hole - depth direction of the ear rod placement hole 38), and the threaded holes communicate with the three ear rod placement holes 38. During use, the ear rod placement hole 38 facing the monkey head can be selected according to the size and position of the monkey head, and then the ear rod 32 inserted into this ear rod placement hole 38 is fixed on both sides of the monkey head through a bolt. The three mutually - spaced ear rod placement holes 38 provide a certain adjustment space for the ear rod 32 in the direction perpendicular to the inclined surface 11, improving the applicable range of the awake monkey head and coil fixing device. In other embodiments, different numbers of ear rod placement holes 38 can also be set according to actual needs.

[0043] In one embodiment, an ear cup 33 is detachably fixed to one end of the ear rod 32 near the head hole 12, and an earplug 34 is provided at one end of the ear cup 33 near the head hole 12. The ear cup 33 can cover the ears of the experimental monkey, and the earplug 34 can block the ear canals of the experimental monkey, thereby reducing the sound heard by the experimental monkey to a certain extent, especially the noise brought by experiments such as magnetic resonance, and further reducing the anxiety of the experimental monkey, making the experimental results more reliable. The ear cup 33 is set to be detachable, which is also convenient for cleaning and replacement, and is also convenient for the installation of the ear rod 32 and the coil. When in use, the ear cup 33 can be removed first, then the ear rod 32 is passed through the ear rod placement hole 38, and then the ear cup 33 is installed at the end of the ear rod 32, and the operation is convenient. In other embodiments, both the ear cup 33 and the earplug 34 are made of sound insulation materials, which further improves the sound insulation effect of the ear cup 33 and the earplug 34 and reduces the adaptation time of the experimental monkey to the noise. In one embodiment, both the ear cup 33 and the earplug 34 are made of flexible materials. The flexible ear cup 33 and earplug 34 can improve the comfort of the experimental monkey, further reduce its anxiety, be more user-friendly, and the experimental results are also more reliable.

[0044] In one embodiment, a coil fixing member 36 is provided on the ear rod 32. The coil can be slidably inserted into the ear rod 32 and can be fixed to the ear rod 32 by the coil fixing member 36. Specifically, an ear rod insertion hole is generally formed in the coil. During installation, the ear cup 33 is removed first, then the ear rod 32 is inserted into the ear rod insertion hole in the coil, and then the ear cup 33 is installed on the ear rod 32. Then, the coil is fixed to the ear rod 32 by the coil fixing member 36. Thus, when the ear cup 33 abuts against both ends of the monkey's head through the ear rod 32, the coil fixed to the ear rod 32 can also closely adhere to the scalp of the experimental monkey. Cooperating with the upper positioning module, the coil can cover the top of the experimental monkey's head. Among them, the coil fixing member 36 can be a pair of screw rings. The diameter of the screw rings is larger than the ear rod insertion hole, and threads are formed around the circumference of the ear rod 32 near the coil. Thus, the pair of screw rings can fix the coil to the position near the ear cup 33 on the ear rod 32.

[0045] In one embodiment, as Figure 5-6As shown in the figure, the upper positioning module includes a second slider 40, a head rod 41, and a head rod fixing member 43. The second slider 40 is disposed on the monkey box 10. The head rod 41 is inserted into the second slider 40. The head rod 41 can slide within the second slider 40 and move closer to or away from the head hole 12. The head rod fixing member 43 is used to fix the head rod 41 on the second slider 40. Specifically, a through head rod placement hole 45 is opened in the second slider 40 in the direction towards the head hole 12. The head rod 41 is inserted into the head rod placement hole 45 of the second slider 40. By manually pushing or pulling the end of the head rod 41 away from the head hole 12, the head rod 41 can be conveniently driven to approach or move away from the head hole 12. Thus, when the monkey head extends out of the head hole 12, the head rod 41 of the upper positioning module can approach and fix the monkey head at the top of the monkey head, thereby restricting the upward movement of the monkey head. Among them, the head rod fixing member 43 can be a bolt. A screw hole is opened on the second slider 40 perpendicular to the length direction of the head rod placement hole 45, and the screw hole communicates with the head rod placement hole 45. Thus, after the head rod 41 is adjusted to a suitable position for restricting the monkey head, the bolt is screwed into the screw hole to press the head rod 41 against the side wall of the head rod placement hole 45, realizing the fixation of the head rod 41, and further realizing the restriction of the upper end of the head rod 41 on the monkey head.

[0046] In other embodiments, the head rod fixing member 43 can also be a pair of lock nuts, etc. Threads matching those on the head rod 41 are provided. Thus, when the head rod 41 reaches a suitable position, the left and right ends of the head rod 41 can be locked by the lock nuts, so that the head rod 41 cannot slide within the head rod placement hole 45, and further the restriction of the upper end of the head rod 41 on the monkey head is realized. The head rod placement hole 45 can be opened in a non-fully penetrating manner, as long as it is ensured that the end of the head rod 41 close to the head hole 12 can extend out of the head rod placement hole 45, and the head rod 41 can slide within the head rod placement hole 45 and move closer to or away from the head hole 12. Multiple head rod placement holes 45 spaced apart from each other can also be opened on the second slider 40, so as to select a suitable head rod placement hole 45 according to the different positions where the monkey head extends, and make the head rod 41 face the monkey head and press against the top of the monkey head.

[0047] In one embodiment, a suction cup 42 for adsorbing the coil is detachably fixed to the end of the head rod 41 close to the head hole 12. The suction cup 42 can be made of materials such as silica gel and rubber. The suction cup 42 can stably adsorb the top of the coil, thereby pressing and fixing the coil on the head of the experimental monkey. By using the suction cup 42 of the head rod 41 and the coil fixing member 36 of the ear rod 32, the coil can be covered on the top of the head of the experimental monkey. The coil is a surface coil for the head. The ear rod 32 and the head rod 41 can be adapted to different coils, such as a top-wrapped coil and a top-partially hollowed-out coil. Different customized surface coils can be replaced to adapt to experimental monkeys of different body types and test situations for magnetic resonance imaging, and can also be adapted to different brain experiments.

[0048] In one embodiment, such as Figure 7As shown, the lower end positioning module includes a third slider 50. The third slider 50 is slidably connected to the monkey cage 10. At least a part of the third slider 50 is disposed at the lower end of the head hole 12, and this part can slide up and down along the inclined surface 11. The third slider 50 can abut against the chin of the experimental monkey, so as to show that the head of the experimental monkey moves downward. Further, one end of the part of the third slider 50 at the lower end of the head hole 12 close to the head hole 12 is set to be concave. The concave third slider 50 can better fit the chin of the experimental monkey, making the experimental monkey more comfortable and reducing the anxiety of the experimental monkey. Further, a soft cushion cloth can be provided in the recess, or the third slider 50 is made of a soft material to further improve the comfort level.

[0049] In one embodiment, the fixing component 30 further includes a first fixing member 37. The first slider 31 is slidably connected to the monkey cage 10 and can slide up and down on the monkey cage 10. The first fixing member 37 is used to fix the first slider 31 on the monkey cage 10. The upper end positioning module further includes a second fixing member 44. The second slider 40 is slidably connected to the monkey cage 10 and can approach or move away from the inclined surface 11. The second fixing member 44 is used to fix the second slider 40 on the monkey cage 10. The lower end positioning module further includes a third fixing member 51. The third fixing member 51 is used to fix the third slider 50 on the monkey cage 10.

[0050] Specifically, a first slide bar 16 is provided on the monkey cage 10, and a first slide groove 39 matching the first slide bar 16 is provided on the first slider 31. The first slider 31 slides up and down on the monkey cage 10 through the first slide bar 16. A second slide bar 17 is provided on the monkey cage 10, and a second slide groove 46 matching the second slide bar 17 is provided on the second slider 40. The second slider 40 slides left and right on the monkey cage 10 through the second slide bar 17. A third slide bar 18 is provided on the monkey cage 10, and a third slide groove 52 matching the third slide bar 18 is provided on the third slider 50. The third slider 50 slides up and down on the monkey cage 10 through the third slide bar 18. The first fixing member 37, the second fixing member 44, and the third fixing member 51 can be a first fixing knob, a second fixing knob, and a third fixing knob respectively. First fixing holes, second fixing holes, and third fixing holes are respectively provided on the first slider 31, the second slider 40, and the third slider 50 corresponding to the first fixing knob, the second fixing knob, and the third fixing knob. The first fixing hole, the second fixing hole, and the third fixing hole are respectively perpendicular to and communicate with the first slide groove 39, the second slide groove 46, and the third slide groove 52. Thus, after the first slider 31, the second slider 40, and the third slider 50 slide to the appropriate positions facing the monkey's head, the first fixing hole, the second fixing hole, and the third fixing hole can respectively abut against the first slide bar 16, the second slide bar 17, and the third slide bar 18 to fix the first slider 31, the second slider 40, and the third slider 50 on the monkey cage 10. In other embodiments, the positions of the slide bar and the slide groove can be interchanged.

[0051] In other embodiments, first through holes, second through holes, and third through holes are respectively formed in the first slider 31, the second slider 40, and the third slider 50 corresponding to the first fixing knob, the second fixing knob, and the third fixing knob. One ends of the first through hole, the second through hole, and the third through hole are all opened on the surface of the monkey cage 10. First screw holes 161, second screw holes, and third screw holes are formed in the monkey cage 10 opposite to the openings. Thus, the first fixing knob, the second fixing knob, and the third fixing knob can respectively pass through the first through hole, the second through hole, and the third through hole and be screwed into the first screw hole 161, the second screw hole, and the third screw hole to respectively lock the first slider 31, the second slider 40, and the third slider 50 on the monkey cage 10. In other embodiments, a plurality of the first fixing knob, the second fixing knob, and the third fixing knob, as well as the first through hole, the second through hole, and the third through hole, and the first screw hole 161, the second screw hole, and the third screw hole are respectively provided for more firm connection.

[0052] In one embodiment, a magnetic resonance imaging system includes a coil and the above-mentioned awake monkey head and coil fixing device. The coil is a head surface coil that covers the top of the experimental monkey's head and adheres to the scalp of the experimental monkey. Different customized surface coils can be replaced to adapt to experimental monkeys of different body types and test conditions for magnetic resonance imaging.

[0053] In the description of this specification, if terms such as "Embodiment 1", "this embodiment", "in one embodiment", etc. appear, it means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the invention or the invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example; moreover, the specific features, structures, materials, or characteristics described can be combined in any one or more embodiments or examples in an appropriate manner.

[0054] In the description of this specification, terms such as "connection", "installation", "fixation", "setting", "having", etc. are all understood in a broad sense. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0055] In the description of this specification, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprise", "include" or any other variant thereof are intended to cover non-exclusive inclusion, such that a process, method, article or apparatus comprising a series of elements not only includes those elements but also includes other elements not expressly listed, or elements inherent to such process, method, article or apparatus. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or apparatus comprising the element.

[0056] The above description of the embodiments is to enable those of ordinary skill in the art to understand and apply the technology of this case. It is obvious that those familiar with the technology in this field can easily make various modifications to these examples and apply the general principles described herein to other embodiments without creative efforts. Therefore, this case is not limited to the above embodiments, and modifications in the following several situations should be within the protection scope of this case: ① A new technical solution implemented based on the technical solution of the present invention in combination with existing common knowledge, and the technical effect produced by this new technical solution does not exceed the technical effect of the present invention; ② An equivalent replacement of some features of the technical solution of the present invention using well-known technology, and the technical effect produced is the same as the technical effect of the present invention; ③ Expansion based on the technical solution of the present invention, and the substantial content of the expanded technical solution does not exceed the technical solution of the present invention; ④ An equivalent transformation made using the content of the specification and drawings of the present invention, directly or indirectly applied in other related technical fields.

Claims

1. A head and coil fixing device for a conscious monkey, comprising a monkey box for accommodating the monkey body. One end face of the monkey box is an upward inclined plane, and a head hole for the monkey's head to expose is opened in the middle of the inclined plane. Characterized in that, It further includes: respectively arranged on the outer surface of the monkey box: A neck positioning module, which includes a pair of neck plates that can approach or move away from each other. The pair of neck plates can jointly form a neck ring that restricts the monkey's neck, and the neck ring is located in the head hole; A left and right positioning module, which includes a pair of fixing components arranged on the left and right sides of the head hole. The pair of fixing components can approach or move away from each other towards the head hole and can drive the coil to approach or move away from the head hole; An upper end positioning module, which is arranged at the upper end of the head hole. The upper end positioning module can approach or move away from the head hole and can drive the coil to approach or move away from the head hole; A lower end positioning module, which is arranged at the lower end of the head hole. The lower end positioning module can approach or move away from the head hole.

2. The head and coil fixing device for a conscious monkey according to claim 1, Characterized in that, The fixing component includes a first slider arranged on the monkey box, an ear rod inserted into the first slider, and an ear rod fixing member. The ear rod can slide in the first slider and approach or move away from the head hole, and the ear rod fixing member is used to fix the ear rod on the first slider.

3. The head and coil fixing device for a conscious monkey according to claim 2, Characterized in that, One end of the ear rod close to the head hole is detachably fixed with an ear cup, and an earplug is arranged at one end of the ear cup close to the head hole.

4. The head and coil fixing device for a conscious monkey according to claim 3, Characterized in that, A coil fixing member is arranged on the ear rod. The coil can be slidably inserted into the ear rod and can be fixed on the ear rod by the coil fixing member.

5. The head and coil fixing device for a conscious monkey according to claim 1, Characterized in that, The upper end positioning module includes a second slider arranged on the monkey box, a head rod inserted into the second slider, and a head rod fixing member. The head rod can slide in the second slider and approach or move away from the head hole, and the head rod fixing member is used to fix the head rod on the second slider.

6. The head and coil fixing device for a conscious monkey according to claim 5, Characterized in that, One end of the head rod close to the head hole is detachably fixed with a suction cup for adsorbing the coil.

7. The head and coil fixing device for a conscious monkey according to claim 1, Characterized in that, The lower end positioning module includes a third slider slidably connected to the monkey box. At least a part of the third slider is arranged at the lower end of the head hole and can slide up and down along the inclined plane.

8. The head and coil fixing device for a conscious monkey according to claim 7, Characterized in that, One end of the part of the third slider at the lower end of the head hole close to the head hole is set to be concave.

9. The head and coil fixing device for a conscious monkey according to claim 2 or 3, Characterized in that, The fixing component further includes a first fixing member. The first slider is slidably connected to the monkey cage and can slide up and down on the monkey cage. The first fixing member is used to fix the first slider on the monkey cage.

10. The awake monkey head and coil fixing device according to claim 5, wherein, the upper end positioning module further includes a second fixing member. The second slider is slidably connected to the monkey cage and can approach or move away from the inclined surface. The second fixing member is used to fix the second slider on the monkey cage.

11. The awake monkey head and coil fixing device according to claim 7, wherein, the lower end positioning module further includes a third fixing member. The third fixing member is used to fix the third slider on the monkey cage.

12. A magnetic resonance imaging system, wherein, it includes a coil and the awake monkey head and coil fixing device according to any one of claims 1-11.

Images