Mussel bionic sebum repair oil and preparation method thereof

Abstract

The invention relates to mussel bionic sebum repairing oil and a preparation method thereof, and belongs to the technical field of cosmetics. The invention provides mussel bionic sebum repair oil and a preparation method thereof, and the mussel bionic sebum repair oil comprises the following raw materials: hydrogenated polyisobutene, mussel oil, five-leaf pine seed oil, meadowfoam seed oil, baobab seed oil, Marula oil, plant extract oil, plant extract moistening oil, soothing oil, light and thin grease, squalane, ceramide and an antioxidant. Through multi-layer combination of natural components and integration of traditional Chinese medicine theories, multiple skin care benefits are provided, a human body sebum composition structure is simulated, a bionic sebum layer is formed on the skin surface, lipid is supplemented, the skin is moistened, the skin barrier is repaired, the skin health is regulated and maintained, and a good repairing effect is achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics and relates to a mussel biomimetic sebum repair oil and a preparation method thereof. Background Art

[0002] The skin is the largest organ for humans to contact with the external environment, covering the whole body and serving as the outermost protective umbrella for other organs of the body. There is a sebum film on its surface, which is formed by the fusion of sebum gland lipids, sweat, and keratinocyte lipids. In addition to moisturizing the skin, it can reduce the evaporation of water on the skin surface, block the intrusion of external dust, dirt, irritants, etc. into the skin, provide a natural barrier protection layer for the skin, and is an important structure for maintaining skin health. Lipids, as the main part of the skin barrier, any change in their composition, content, or distribution ratio will affect the skin condition.

[0003] The lipids on the skin surface mainly come from the secretion of sebaceous glands and the lipids of epidermal cells, and are composed of squalene, wax esters, cholesterol, cholesterol esters, triglycerides, diglycerides, monoglycerides, and free fatty acids, etc., which play an important role in the human body. First of all, the lipids on the skin surface can reduce the oxidative damage of ultraviolet rays to the skin; secondly, it can prevent excessive evaporation of skin water and the large influx of external water and gas substances, so that the water content of the skin remains normal. The lipids on the skin surface can also moisten the skin, making the skin flexible, smooth, and shiny; in addition, some free fatty acids in the sebum film can inhibit the growth of certain pathogenic microorganisms and have an anti-infection effect, which is crucial for maintaining the ecological stability of the resident bacteria on the human skin surface.

[0004] At present, there are a wide variety of skin barrier repair cosmetics. Most of them reduce inflammation of damaged skin by strengthening the moisture retention of the skin surface or adding soothing ingredients, but they cannot fundamentally solve the problems of damaged barrier function and sebum loss. In order to overcome the deficiencies of the existing technology, the present invention prepares a mussel biomimetic sebum repair oil and a preparation method thereof. Summary of the Invention

[0005] The purpose of the present invention is to provide a mussel biomimetic sebum repair oil and a preparation method thereof. Through the multi-level combination of natural ingredients and the integration of traditional Chinese medicine theory, it provides multiple skin care benefits, simulates the composition structure of human sebum, forms a biomimetic sebum layer on the skin surface, replenishes lipids, moisturizes the skin, repairs the skin barrier, regulates and maintains skin health, and achieves a good repair effect.

[0006] The purpose of the present invention can be achieved by the following technical solutions:

[0007] A mussel - bionic sebum repair oil. The raw materials of the mussel - bionic sebum repair oil, by weight, include 10 - 89 parts of hydrogenated polyisobutene, 0.1 - 3 parts of mussel oil, 0.1 - 3 parts of Japanese umbrella pine seed oil, 1 - 53 parts of Limnanthes alba seed oil, 0.5 - 15 parts of Adansonia digitata seed oil, 0.5 - 15 parts of Sclerocarya birrea seed oil, 1 - 5 parts of plant extract oil, 1 - 5 parts of plant extract nourishing oil, 1 - 4 parts of soothing oil, 1 - 10 parts of light grease, 1 - 48 parts of squalane, 0.25 - 5 parts of ceramide, and 0.05 - 2 parts of antioxidant.

[0008] Further, the preparation method of the Japanese umbrella pine seed oil is as follows:

[0009] Wash the Japanese umbrella pine seeds, then dry them at a low temperature of 35°C until the water content is 8 - 10%, take them out and crush them until the seed shells crack but the kernels are intact, then transfer them to a cold press, and carry out pressing at a temperature of 40°C and a pressure of 10 - 15 MPa / h. Stop pressing until no more oil comes out, and obtain the crude Japanese umbrella pine seed oil. Centrifuge it at a speed of 3000 - 5000 rpm for 10 - 20 min, and then filter it through a 200 - mesh filter cloth to obtain a transparent oil. Add 0.1% of vitamin E by mass of the transparent oil, stir evenly, and obtain the Japanese umbrella pine seed oil.

[0010] Further, the preparation method of the plant extract oil is as follows:

[0011] Add caprylic / capric triglyceride and hydrogenated polyisobutene to a stirring tank, start stirring at a speed of 150 - 250 rpm for 4 - 6 min, then successively add peony extract, licorice root extract, perilla seed extract, flaxseed extract, buckwheat seed extract, Lycium barbarum fruit extract, lotus seed extract, and silybum marianum seed extract. Keep the rotation speed unchanged, and stir for 3 min after adding each extract. Then add pentaerythrityl tetra - (di - tert - butyl hydroxyhydrocinnamate), stir for 4 - 6 min, homogenize at a speed of 4500 - 5500 rpm for 2 - 4 min, and then filter with a 200 - mesh filter cloth to obtain the plant extract oil.

[0012] Further, the raw materials of the plant extract oil, by mass percentage, include 5.8 - 6.2% of hydrogenated polyisobutene, 3 - 5% of peony extract, 1.5 - 2.5% of licorice root extract, 1 - 2% of perilla seed extract, 1 - 2% of flaxseed extract, 1 - 2% of buckwheat seed extract, 0.2 - 0.8% of Lycium barbarum fruit extract, 0.2 - 0.8% of lotus seed extract, 0.2 - 0.8% of silybum marianum seed extract, 0.13 - 0.17% of pentaerythrityl tetra - (di - tert - butyl hydroxyhydrocinnamate), and the balance of caprylic / capric triglyceride.

[0013] Further, the preparation method of the plant extract nourishing oil is as follows:

[0014] Add caprylic / capric triglyceride and hydrogenated polyisobutene to a stirring tank. After starting, stir at a speed of 150 - 250 rpm for 4 - 6 min. Then, successively add Ganoderma lucidum extract, Panax ginseng root extract, Paeonia suffruticosa extract, and Saussurea involucrata extract. Keep the rotation speed unchanged, and stir for 3 min after adding each extract. Then add pentaerythrityl tetra(bis - tert - butylhydroxyhydrocinnamate), stir for 4 - 6 min, homogenize at a speed of 3500 - 4500 rpm for 1.5 - 2.5 min, and then filter using a 200 - mesh filter cloth to obtain the plant extract nourishing oil.

[0015] Furthermore, the raw materials of the plant extract nourishing oil, by mass percentage, include 18 - 20% hydrogenated polyisobutene, 5 - 7% Ganoderma lucidum extract, 2 - 4% Panax ginseng root extract, 2 - 4% Paeonia suffruticosa extract, 0.4 - 0.6% Saussurea involucrata extract, 0.13 - 0.17% pentaerythrityl tetra(bis - tert - butylhydroxyhydrocinnamate), and the balance of caprylic / capric triglyceride.

[0016] Furthermore, the preparation method of the soothing oil is as follows:

[0017] Mix hexyl decanol and stearic acid, heat to 58 - 62 °C, stir until completely dissolved to obtain a mixture. Add bisabolol to the mixture, stir at a speed of 50 - 150 rpm for 4 - 6 min, cool to 39 - 41 °C, then add cetyl N - palmitoylhydroxyprolinate, keep the rotation speed unchanged and stir evenly. After cooling to room temperature, add brassinosteroids, stir evenly, homogenize at a speed of 2500 - 3500 rpm for 2 - 4 min, and then filter using a 200 - mesh filter cloth to obtain the soothing oil.

[0018] Furthermore, the raw materials of the soothing oil, by mass percentage, include 2 - 3% bisabolol, 2 - 3% cetyl N - palmitoylhydroxyprolinate, 2 - 3% stearic acid, 0.3 - 0.7% brassinosteroids, and the balance of hexyl decanol.

[0019] Furthermore, the light oil, by mass percentage, includes 88 - 92% C9 - 12 alkane and the balance of coco - alcohol caprylate / caprate; the antioxidant, by mass percentage, includes 65 - 75% vitamin E and the balance of sunflower seed oil; the ceramide is prepared by mixing 2.8 - 3.2% of ceramide NP by mass percentage and the balance of isostearyl alcohol, and stirring until completely dissolved in a 55 °C water bath.

[0020] Furthermore, the preparation method includes the following steps:

[0021] At room temperature, hydrogenated polyisobutene, mussel oil, Japanese white pine seed oil, Limnanthes alba seed oil, Adansonia digitata seed oil, Sclerocarya birrea seed oil, plant extract oil, plant extract nourishing oil, soothing oil, light grease, squalane, ceramide and antioxidant are added to the oil-phase pot in sequence according to the proportion. After mixing evenly, the mixture is discharged and homogenized at a speed of 5000 - 8000 rpm for 6 - 8 min to obtain mussel bionic sebum repair oil.

[0022] Advantages of the present invention:

[0023] (1) The present invention uses low-temperature drying and cold rolling processes to prepare Japanese white pine seed oil, maximizing the retention of active ingredients such as natural fatty acids in Japanese white pine seed oil. It contains a large amount of beneficial pinolenic acid, which can effectively inhibit the activity of the main stimulatory mediator lipoxygenase in the skin, having an anti-inflammatory effect. In addition, Japanese white pine seed oil also contains natural antioxidant components, which can help relieve oxidative damage to the skin and play an important role in protecting the skin, preventing and alleviating inflammation, and enhancing the skin's protective ability in the repair oil.

[0024] (2) Based on the traditional Chinese medicine theory of "qi promoting blood circulation", the plant extract oil of the present invention follows the formula principle of "emperor, minister, assistant, and courier". The emperor herbs perilla seeds promote qi and peony seeds activate blood circulation. The minister herbs buckwheat seeds promote qi and flax seeds activate blood circulation. The emperor and minister herbs work together synergistically to promote qi and activate blood circulation. The assistant herbs wolfberry fruits and lotus seeds tonify and nourish to care for the skin. The courier herbs silybum marianum seeds and licorice together have the effect of clearing heat and detoxifying. The cooperation of each component enables the plant extract oil to deeply nourish, repair and protect the skin on the basis of regulating qi and blood, improving the overall skin health level.

[0025] (3) Based on the traditional Chinese medicine thought of "holistic and syndrome differentiation", the plant extract nourishing oil of the present invention follows the formula principle of "emperor, minister, assistant, and courier". The emperor herb Ganoderma lucidum tonifies qi and blood. The minister herb Saussurea involucrata nourishes blood and promotes blood circulation to assist the emperor herb in tonifying qi and blood. The assistant herb ginseng tonifies and nourishes. The courier herb peony seeds promote blood circulation to remove blood stasis. The whole formula mainly nourishes and activates blood circulation, supplemented by tonifying and nourishing, making the skin present a healthy and shiny state, achieving a skin care effect that takes both symptoms and root causes into account.

[0026] (4)On this basis, the present invention further adds components such as mussel oil, Limnanthes alba seed oil, Adansonia digitata seed oil, Sclerocarya birrea seed oil, and soothing oil. Among them, mussel mucin contained in mussel oil has the adhesion characteristics of mimicking the sebum layer, which can repair the skin barrier, enhance the elasticity of the skin and reduce flushing; Limnanthes alba seed oil is rich in long-chain fatty acids, which can quickly supplement the fatty acids required by the skin and help restore and strengthen the skin barrier; Adansonia digitata seed oil contains unsaturated free fatty acids, amino acids, sterols, saponins, terpenoids, etc., which promote the normal function of the sebaceous glands and repair damaged skin; Sclerocarya birrea seed oil is rich in vitamin E, has strong antioxidant properties, and can enhance the hydration of the skin, with moisturizing and tissue repair capabilities; the soothing oil is compounded with components such as bisabolol and brassinosteroids, which can effectively relieve skin irritation and discomfort, reduce skin dryness and sensitivity symptoms at the source, soothe damaged skin, enhance the natural defense of the skin, and maintain the integrity of the skin barrier.

[0027] (5)Through the multi-level combination of natural ingredients and the integration of traditional Chinese medicine theory, the present invention provides multiple skin care benefits, mimics the composition structure of human sebum, forms a biomimetic sebum layer on the skin surface, replenishes lipids, moisturizes the skin, repairs the skin barrier, regulates and maintains skin health, and achieves a good repair effect. Detailed implementation manners

[0028] To further elaborate on the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following, in combination with embodiments, details the specific implementation manners, structures, features, and their effects according to the present invention as follows.

[0029] In all examples and comparative examples of the present invention, hydrogenated polyisobutene was directly purchased from the market and all were purchased from Clariant Trading (Shanghai) Co., Ltd.; mussel oil was directly purchased from the market and all were purchased from Jiangyin Berryson Biochemical Technology Co., Ltd.; Limnanthes alba seed oil was directly purchased from the market and all were purchased from Guangzhou Minghui Fine Chemical Co., Ltd.; Adansonia digitata oil was directly purchased from the market and all were purchased from Guangzhou Saco Trading Co., Ltd.; Sclerocarya birrea seed oil was directly purchased from the market and all were purchased from Guangzhou Zhongbo New Materials Co., Ltd.; triglyceride of caprylic / capric acid, peony extract, licorice root extract, perilla seed extract, flaxseed extract, buckwheat seed extract, Lycium barbarum fruit extract, lotus seed extract, silybum marianum seed extract, Ganoderma lucidum extract, ginseng root extract, Saussurea involucrata extract, pentaerythrityl tetra(bis-tert-butyl hydroxyhydrocinnamate) were directly purchased from the market and all were purchased from Beijing Orient Miao Sen Biotechnology Co., Ltd.; hexyl decanol, stearic acid, bisabolol, N-palmitoyl hydroxyproline cetyl ester, brassinosteroids were directly purchased from the market and all were purchased from Guangzhou Aoxue Biotechnology Co., Ltd.; C9-12 alkane, coco alcohol-caprylate / caprate were directly purchased from the market and all were purchased from Guangzhou Youran Biotechnology Co., Ltd.; vitamin E, sunflower seed oil were directly purchased from the market and all were purchased from Amystar (China) Co., Ltd.; squalane was directly purchased from the market and all were purchased from Guangzhou Saco Trading Co., Ltd.; ceramide NP, isostearyl alcohol were directly purchased from the market and all were purchased from Guangzhou Junming Trading Co., Ltd.

[0030] Example 1

[0031] A mussel bionic sebum repair oil. The raw materials of the mussel bionic sebum repair oil in this example are calculated by weight and include 10 parts of hydrogenated polyisobutene, 0.1 part of mussel oil, 0.1 part of Pinus parviflora seed oil, 1 part of Limnanthes alba seed oil, 0.5 part of Adansonia digitata seed oil, 0.5 part of Sclerocarya birrea seed oil, 1 part of plant extract oil, 1 part of plant extract nourishing oil, 1 part of soothing oil, 1 part of light grease, 1 part of squalane, 0.25 part of ceramide and 0.05 part of antioxidant.

[0032] The preparation method of the Pinus parviflora seed oil in this example is as follows:

[0033] After cleaning the Pinus parviflora seeds, they are dried at a low temperature of 35°C until the water content is 8%, taken out and crushed until the seed shells crack but the kernels are intact, and then transferred to a cold press. Pressing is carried out at a temperature of 40°C and a pressure of 10 MPa / h until no more oil is produced and then stopped to obtain the virgin Pinus parviflora seed oil. Centrifuge at a speed of 3000 rpm for 10 min, and then filter through a 200-mesh filter cloth to obtain a transparent oil. Add 0.1% of vitamin E based on the mass of the transparent oil and stir evenly to obtain the Pinus parviflora seed oil.

[0034] The preparation method of the plant extract oil in this embodiment is as follows:

[0035] Add caprylic / capric triglyceride and hydrogenated polyisobutene into a stirring tank. After starting, stir at a speed of 150 rpm for 4 minutes. Then, successively add peony extract, licorice root extract, perilla seed extract, flaxseed extract, buckwheat seed extract, wolfberry fruit extract from Ningxia, lotus seed extract, and silybum marianum seed extract. Keep the rotation speed unchanged, and stir for 3 minutes after adding each extract. Then add pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate), stir for 4 minutes, homogenize at a speed of 4500 rpm for 2 minutes, and then filter with a 200-mesh filter cloth to obtain the plant extract oil.

[0036] The raw materials of the plant extract oil in this embodiment are calculated by mass percentage, including 5.8% hydrogenated polyisobutene, 3% peony extract, 1.5% licorice root extract, 1% perilla seed extract, 1% flaxseed extract, 1% buckwheat seed extract, 0.2% wolfberry fruit extract from Ningxia, 0.2% lotus seed extract, 0.2% silybum marianum seed extract, 0.13% pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate), and the balance of caprylic / capric triglyceride.

[0037] The preparation method of the plant extract nourishing oil in this embodiment is as follows:

[0038] Add caprylic / capric triglyceride and hydrogenated polyisobutene into a stirring tank. After starting, stir at a speed of 150 rpm for 4 minutes. Then, successively add ganoderma lucidum extract, ginseng root extract, peony extract, and snow lotus flower extract. Keep the rotation speed unchanged, and stir for 3 minutes after adding each extract. Then add pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate), stir for 4 minutes, homogenize at a speed of 3500 rpm for 1.5 minutes, and then filter with a 200-mesh filter cloth to obtain the plant extract nourishing oil.

[0039] The raw materials of the plant extract nourishing oil in this embodiment are calculated by mass percentage, including 18% hydrogenated polyisobutene, 5% ganoderma lucidum extract, 2% ginseng root extract, 2% peony extract, 0.4% snow lotus flower extract, 0.13% pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate), and the balance of caprylic / capric triglyceride.

[0040] The preparation method of the soothing oil in this embodiment is as follows:

[0041] Mix hexyl decanol and stearic acid, heat the mixture to 58 °C, stir until completely dissolved to obtain a mixture. Add bisabolol to the mixture, stir at a speed of 50 rpm for 4 min, cool to 39 °C, then add cetyl N - palmitoyl - hydroxyprolinate, keep the speed unchanged and stir evenly. After cooling to room temperature, add brassinosteroids, stir evenly, homogenize at a speed of 2500 rpm for 2 min, and then filter through a 200 - mesh filter cloth to obtain the soothing oil.

[0042] By mass percentage, the raw materials of the soothing oil in this example include 2% bisabolol, 2% cetyl N - palmitoyl - hydroxyprolinate, 2% stearic acid, 0.3% brassinosteroids, and the balance of hexyl decanol.

[0043] By mass percentage, the light - thin grease in this example includes 88% C9 - 12 alkane and the balance of coco - caprylate / caprate; by mass percentage, the antioxidant includes 65% vitamin E and the balance of sunflower seed oil; the ceramide is prepared by mixing 2.8% of ceramide NP by mass percentage and the balance of isostearyl alcohol, and stirring until completely dissolved in a 55 °C water bath.

[0044] The preparation method of this example includes the following steps:

[0045] At room temperature, add hydrogenated polyisobutene, mussel oil, Japanese white pine seed oil, Limnanthes alba seed oil, Adansonia digitata seed oil, Sclerocarya birrea seed oil, plant extract oil, plant extract nourishing oil, soothing oil, light - thin grease, squalane, ceramide, and antioxidant into the oil - phase pot in sequence according to the proportion, mix evenly and then discharge, homogenize at a speed of 5000 rpm for 6 min to obtain the mussel - bionic sebum repair oil.

[0046] Example 2

[0047] A mussel - bionic sebum repair oil. By weight, the raw materials of the mussel - bionic sebum repair oil in this example include 89 parts of hydrogenated polyisobutene, 3 parts of mussel oil, 3 parts of Japanese white pine seed oil, 1 - 53 parts of Limnanthes alba seed oil, 15 parts of Adansonia digitata seed oil, 15 parts of Sclerocarya birrea seed oil, 5 parts of plant extract oil, 5 parts of plant extract nourishing oil, 4 parts of soothing oil, 10 parts of light - thin grease, 48 parts of squalane, 5 parts of ceramide, and 2 parts of antioxidant.

[0048] The preparation method of the Japanese white pine seed oil in this example is as follows:

[0049] After cleaning the seeds of Pinus parviflora Siebold & Zucc., they are dried at a low temperature of 35°C until the water content is 10%, taken out and crushed until the seed shells crack but the kernels remain intact, and then transferred to a cold press. Pressing is carried out at a temperature of 40°C and a pressure of 15 MPa / h until no more oil is produced, and then stopped to obtain the crude Pinus parviflora Siebold & Zucc. seed oil. Centrifugation is carried out at a speed of 5000 rpm for 20 min, and then filtered through a 200-mesh filter cloth to obtain a transparent oil. Vitamin E accounting for 0.1% of the mass of the transparent oil is added thereto, and after stirring evenly, Pinus parviflora Siebold & Zucc. seed oil is obtained.

[0050] The preparation method of the phytocannabinoid oil in this example is as follows:

[0051] Caprylic / capric triglyceride and hydrogenated polyisobutene are added to a stirring tank. After starting, stirring is carried out at a speed of 250 rpm for 6 min, and then peony extract, licorice root extract, perilla seed extract, flaxseed extract, buckwheat seed extract, wolfberry fruit extract, lotus seed extract and silybum marianum seed extract are added in sequence. The rotation speed is maintained unchanged, and stirring is required for 3 min after adding each extract. Then, pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate) is added, and after stirring for 6 min, homogenization is carried out at a speed of 5500 rpm for 4 min, and then filtered through a 200-mesh filter cloth to obtain phytocannabinoid oil.

[0052] The raw materials of the phytocannabinoid oil in this example, calculated by mass percentage, include 6.2% hydrogenated polyisobutene, 3 - 5% peony extract, 2.5% licorice root extract, 2% perilla seed extract, 2% flaxseed extract, 2% buckwheat seed extract, 0.8% wolfberry fruit extract, 0.8% lotus seed extract, 0.8% silybum marianum seed extract, 0.17% pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate) and the balance of caprylic / capric triglyceride.

[0053] The preparation method of the phytocannabinoid nourishing oil in this example is as follows:

[0054] Caprylic / capric triglyceride and hydrogenated polyisobutene are added to a stirring tank. After starting, stirring is carried out at a speed of 250 rpm for 6 min, and then ganoderma lucidum extract, ginseng root extract, peony extract and snow lotus extract are added in sequence. The rotation speed is maintained unchanged, and stirring is required for 3 min after adding each extract. Then, pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate) is added, and after stirring for 6 min, homogenization is carried out at a speed of 4500 rpm for 2.5 min, and then filtered through a 200-mesh filter cloth to obtain phytocannabinoid nourishing oil.

[0055] The raw materials of the phytocannabinoid nourishing oil in this example, calculated by mass percentage, include 20% hydrogenated polyisobutene, 7% ganoderma lucidum extract, 4% ginseng root extract, 4% peony extract, 0.6% snow lotus extract, 0.17% pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate) and the balance of caprylic / capric triglyceride.

[0056] The preparation method of the soothing oil in this embodiment is as follows:

[0057] Mix hexyl decanol and stearic acid and heat to 62°C, stir until completely dissolved to obtain a mixture. Add bisabolol to the mixture, stir at 150 rpm for 6 min, cool to 41°C, then add cetyl N - palmitoyl hydroxyproline, keep the rotation speed unchanged and stir evenly. After cooling to room temperature, add brassinosteroids, stir evenly, homogenize at 3500 rpm for 4 min, and then filter with a 200 - mesh filter cloth to obtain the soothing oil.

[0058] The raw materials of the soothing oil in this embodiment are calculated by mass percentage, including 3% bisabolol, 3% cetyl N - palmitoyl hydroxyproline, 3% stearic acid, 0.7% brassinosteroids and the balance of hexyl decanol.

[0059] The light - weight oil in this embodiment is calculated by mass percentage, including 92% C9 - 12 alkane and the balance of coco - caprylic / capric glycerides; the antioxidant is calculated by mass percentage, including 75% vitamin E and the balance of sunflower seed oil; the ceramide is prepared by mixing 3.2% ceramide NP by mass percentage and the balance of isostearyl alcohol and stirring until completely dissolved in a 55°C water bath.

[0060] The preparation method of this embodiment includes the following steps:

[0061] At room temperature, add hydrogenated polyisobutene, mussel oil, Japanese white pine seed oil, Limnanthes alba seed oil, Adansonia digitata seed oil, Sclerocarya birrea seed oil, plant extract oil, plant extract nourishing oil, soothing oil, light - weight oil, squalane, ceramide and antioxidant into the oil - phase pot in sequence according to the proportion, mix evenly and then discharge. Homogenize at 8000 rpm for 8 min to obtain the mussel - bionic sebum repair oil.

[0062] Example 3

[0063] A mussel - bionic sebum repair oil. The raw materials of the mussel - bionic sebum repair oil in this embodiment are calculated by weight parts, including 49.5 parts of hydrogenated polyisobutene, 1.55 parts of mussel oil, 1.55 parts of Japanese white pine seed oil, 27 parts of Limnanthes alba seed oil, 1 part of Adansonia digitata seed oil, 1 part of Sclerocarya birrea seed oil, 3 parts of plant extract oil, 3 parts of plant extract nourishing oil, 2.5 parts of soothing oil, 5.5 parts of light - weight oil, 24.5 parts of squalane, 2.62 parts of ceramide and 1.03 parts of antioxidant.

[0064] The preparation method of the Japanese white pine seed oil in this embodiment is as follows:

[0065] After cleaning the Korean pine seeds, they are dried at a low temperature of 35°C until the water content is 9%. Then, they are taken out and crushed until the seed shells crack but the kernels remain intact. Next, they are transferred to a cold press and pressed at a temperature of 40°C and a pressure of 12.5 MPa / h until no more oil is produced. After stopping, the crude Korean pine seed oil is obtained. It is centrifuged at a speed of 4000 rpm for 15 minutes and then filtered through a 200-mesh filter cloth to obtain a transparent oil. Vitamin E accounting for 0.1% of the mass of the transparent oil is added thereto and stirred evenly to obtain the Korean pine seed oil.

[0066] The preparation method of the phytocannabinoid oil in this example is as follows:

[0067] Caprylic / capric triglyceride and hydrogenated polyisobutene are added to a stirring tank. After starting, it is stirred at a speed of 200 rpm for 5 minutes. Then, peony extract, licorice root extract, perilla seed extract, flaxseed extract, buckwheat seed extract, wolfberry fruit extract, lotus seed extract, and silybum marianum seed extract are added in sequence. The rotation speed is maintained unchanged, and it needs to be stirred for 3 minutes after adding each extract. Then, pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate) is added and stirred for 5 minutes. Then, it is homogenized at a speed of 5000 rpm for 3 minutes and then filtered through a 200-mesh filter cloth to obtain the phytocannabinoid oil.

[0068] The raw materials of the phytocannabinoid oil in this example, by mass percentage, include 6% hydrogenated polyisobutene, 4% peony extract, 2% licorice root extract, 1.5% perilla seed extract, 1.5% flaxseed extract, 1.5% buckwheat seed extract, 0.5% wolfberry fruit extract, 0.5% lotus seed extract, 0.5% silybum marianum seed extract, 0.15% pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate), and the balance of caprylic / capric triglyceride.

[0069] The preparation method of the phytocannabinoid nourishing oil in this example is as follows:

[0070] Caprylic / capric triglyceride and hydrogenated polyisobutene are added to a stirring tank. After starting, it is stirred at a speed of 200 rpm for 5 minutes. Then, ganoderma lucidum extract, ginseng root extract, peony extract, and snow lotus extract are added in sequence. The rotation speed is maintained unchanged, and it needs to be stirred for 3 minutes after adding each extract. Then, pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate) is added and stirred for 5 minutes. Then, it is homogenized at a speed of 4000 rpm for 2 minutes and then filtered through a 200-mesh filter cloth to obtain the phytocannabinoid nourishing oil.

[0071] The raw materials of the phytocannabinoid nourishing oil in this example, by mass percentage, include 19% hydrogenated polyisobutene, 6% ganoderma lucidum extract, 3% ginseng root extract, 3% peony extract, 0.5% snow lotus extract, 0.15% pentaerythritol tetra(bis-tert-butyl hydroxyhydrocinnamate), and the balance of caprylic / capric triglyceride.

[0072] The preparation method of the soothing oil in this example is as follows:

[0073] Mix hexyl decanol and stearic acid, heat to 60 °C, stir until completely dissolved to obtain a mixture. Add bisabolol to the mixture, stir at a speed of 100 rpm for 5 min, cool to 40 °C, then add cetyl N - palmitoyl - hydroxyprolinate, keep the speed unchanged and stir evenly. After cooling to room temperature, add brassinosteroids, stir evenly, homogenize at a speed of 3000 rpm for 3 min, and then filter with a 200 - mesh filter cloth to obtain the soothing oil.

[0074] The raw materials of the soothing oil in this example, by mass percentage, include 2.5% bisabolol, 2.5% cetyl N - palmitoyl - hydroxyprolinate, 2.5% stearic acid, 0.5% brassinosteroids, and the balance of hexyl decanol.

[0075] The light - thin grease in this example, by mass percentage, includes 90% C9 - 12 alkane and the balance of coco - caprylate / caprate; the antioxidant, by mass percentage, includes 70% vitamin E and the balance of sunflower seed oil; the ceramide is prepared by mixing 3% ceramide NP by mass percentage and the balance of isostearyl alcohol, and stirring until completely dissolved in a 55 °C water bath.

[0076] The preparation method of this example includes the following steps:

[0077] At room temperature, add hydrogenated polyisobutene, mussel oil, Japanese white pine seed oil, Limnanthes alba seed oil, Adansonia digitata seed oil, Sclerocarya birrea seed oil, plant extract oil, plant extract nourishing oil, soothing oil, light - thin grease, squalane, ceramide, and antioxidant into the oil - phase pot in sequence according to the proportion, mix evenly and then discharge. Homogenize at a speed of 6500 rpm for 7 min to obtain the mussel - bionic sebum repair oil.

[0078] Comparative Example 1

[0079] On the basis of Example 3, remove the Japanese white pine seed oil and replace it with an equal weight of hydrogenated polyisobutene, and keep other conditions the same as those in Example 3.

[0080] Comparative Example 2

[0081] On the basis of Example 3, keep other conditions the same, and change the preparation method of the Japanese white pine seed oil to:

[0082] Wash the Japanese white pine seeds, dry them at a low temperature of 35 °C until the water content is 9%, take them out and crush them to 60 - mesh, add them to n - hexane according to the solid - liquid ratio of 1:3, stir at 55 °C for 2 h, centrifuge at a speed of 4000 rpm for 15 min, and then filter through a 200 - mesh filter cloth to obtain a transparent grease. Recover n - hexane by rotary evaporation at 68 °C to obtain the Japanese white pine seed oil.

[0083] Comparative Example 3

[0084] Based on Example 3, the Limnanthes alba seed oil was removed and replaced with an equal weight of Adansonia digitata seed oil, and other conditions were the same as those in Example 3.

[0085] Comparative Example 4

[0086] Based on Example 3, the Adansonia digitata seed oil was removed and replaced with an equal weight of Sclerocarya birrea seed oil, and other conditions were the same as those in Example 3.

[0087] Comparative Example 5

[0088] Based on Example 3, the Sclerocarya birrea seed oil was removed and replaced with an equal weight of Limnanthes alba seed oil, and other conditions were the same as those in Example 3.

[0089] Comparative Example 6

[0090] Based on Example 3, the plant extract oil was removed and replaced with an equal weight of plant extract nourishing oil, and other conditions were the same as those in Example 3.

[0091] Comparative Example 7

[0092] Based on Example 3, the plant extract nourishing oil was removed and replaced with an equal weight of soothing oil, and other conditions were the same as those in Example 3.

[0093] Comparative Example 8

[0094] Based on Example 3, the soothing oil was removed and replaced with an equal weight of plant extract oil, and other conditions were the same as those in Example 3.

[0095] Comparative Example 9

[0096] Based on Example 3, while keeping other conditions the same, the preparation method of the plant extract oil was changed to:

[0097] Add caprylic / capric triglyceride, hydrogenated polyisobutene, Paeonia suffruticosa extract, Glycyrrhiza glabra root extract, Perilla frutescens seed extract, Linum usitatissimum seed extract, Fagopyrum esculentum seed extract, Lycium barbarum fruit extract, Nelumbo nucifera seed extract and Silybum marianum seed extract into a stirring tank. After starting, stir at a speed of 200 rpm for 34 min, then homogenize at a speed of 5000 rpm for 3 min, and then filter with a 200-mesh filter cloth to obtain the plant extract oil.

[0098] 1. Patch test

[0099] Fifteen volunteers with healthy skin, half male and half female, aged between 20 and 45, were selected. All volunteers had no history of skin diseases, no known allergies to the test materials, and had not used any drugs or cosmetics that might affect skin reactions for at least 2 weeks before the test. Patch tests were conducted according to the skin reaction grading standard in the "Technical Specifications for Cosmetics Safety" (2015 edition), and the skin reaction level was set from 0 to 4, where level 0 was a negative reaction.

[0100] Using the mussel biomimetic sebum repair oil extracted in Examples 1 - 3 as the test sample, 0.02 ± 0.005 ml of the sample was respectively dropped into the patch tester, and then attached to the flexor side of the subject's forearm with a low - sensitization tape. After 24 hours, the patch tester was removed, and the skin reactions at 0.5 h, 24 h, and 48 h after removal were observed respectively. The test results are shown in Table 1.

[0101] Table 1

[0102]

[0103] As can be seen from Table 1, the mussel biomimetic sebum repair oil prepared in Examples 1 - 3 of the present invention has safe ingredients, is mild and non - irritating, and has no adverse reactions during use.

[0104] 2. Performance detection

[0105] For the mussel biomimetic sebum repair oil prepared in Example 3 and Comparative Examples 1 - 9, 50 rats with a weight of 250 ± 2 g, half male and half female, were selected. The hair on the left side of the spine on the back of each rat was shaved, and the sample application area and the blank area were cut out as the test areas, with an area of 3 cm × 3 cm for each. There was at least a 1 - cm interval between the two test areas. The basic value of the trans - epidermal water loss rate of the rats' skin before tape stripping was measured using a VAPOSCAN trans - epidermal water loss meter. Then, the tape stripping method was operated 10 times to cause skin barrier damage, and the skin data values after tape stripping were measured 30 minutes later. In the sample application area, (2.0 ± 0.1) ml / cm 2 of the test sample was evenly applied, which was the sample group, and the blank area was not treated at all, which was the blank group. The trans - epidermal water loss rate of the skin was measured at 2 h and 4 h after application, and the corresponding TEWL recovery rate was calculated to evaluate the repair effect of the test sample. The specific values were averaged and recorded as shown in Table 2 below.

[0106] Among them, the TEWL recovery rate % = (the test value after tape stripping - the test value after using the sample) / (the test value after tape stripping - the test value before tape stripping) × 100%.

[0107] Table 2

[0108]

[0109]

[0110] As can be seen from Table 1, the mussel biomimetic sebum repair oil prepared in the embodiments of the present invention can effectively repair the skin barrier, nourish the skin, and has a good repair effect.

[0111] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. Although the present invention has been disclosed above with the preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to equivalent embodiments by using the disclosed technical content within the scope of the technical solution of the present invention. However, as long as it does not depart from the content of the technical solution of the present invention, any indirect modification, equivalent change, and modification made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A mussel bionic sebum repair oil, characterized in that: The raw materials of the mussel bionic cortical repair oil include, by weight, 10-89 parts of hydrogenated polyisobutylene, 0.1-3 parts of mussel oil, 0.1-3 parts of pine seed oil, 1-53 parts of meadowfoam seed oil, 0.5-15 parts of baobab seed oil, 0.5-15 parts of marula oil, 1-5 parts of plant extract oil, 1-5 parts of plant extract nourishing oil, 1-4 parts of soothing oil, 1-10 parts of light oil, 1-48 parts of squalane, 0.25-5 parts of ceramide and 0.05-2 parts of antioxidant.

2. The mussel bionic sebum repair oil according to claim 1, characterized in that: The preparation method of the pine seed oil is as follows: The seeds of Pinus quinquefolia are washed and dried at 35°C to a moisture content of 8-10%, taken out and crushed until the seed shell is cracked but the seed kernel is intact, and then transferred to a cold press, pressed at a temperature of 40°C and a pressure of 10-15MPa / h until no more oil is produced to obtain virgin Pinus quinquefolia seed oil, centrifuged at a speed of 3000-5000rpm for 10-20min, and then filtered through a 200-mesh filter cloth to obtain transparent oil, to which 0.1% of vitamin E by mass of the transparent oil is added, and stirred evenly to obtain Pinus quinquefolia seed oil.

3. The mussel bionic sebum repair oil according to claim 1, characterized in that: The preparation method of the plant extract oil is: Add caprylic / capric triglyceride and hydrogenated polyisobutene to a stirring tank, stir at 150-250 rpm for 4-6 minutes after starting, then add peony extract, licorice root extract, perilla seed extract, flax seed extract, buckwheat seed extract, Ningxia wolfberry fruit extract, lotus seed extract and milk thistle seed extract in sequence, maintain the speed unchanged, and stir for 3 minutes after adding each extract, then add pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), stir for 4-6 minutes, homogenize at 4500-5500 rpm for 2-4 minutes, and then filter with a 200-mesh filter cloth to obtain plant extract oil.

4. A mussel bionic sebum repair oil according to claim 3, characterized in that: The raw materials of the plant extract oil include, by mass percentage, 5.8-6.2% hydrogenated polyisobutene, 3-5% peony extract, 1.5-2.5% liquorice root extract, 1-2% perilla seed extract, 1-2% flaxseed extract, 1-2% buckwheat seed extract, 0.2-0.8% Ningxia wolfberry fruit extract, 0.2-0.8% lotus seed extract, 0.2-0.8% milk thistle seed extract, 0.13-0.17% pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate) ester and the remainder caprylic / capric triglyceride.

5. The mussel bionic sebum repair oil according to claim 1, characterized in that: The preparation method of the plant-based nourishing oil is as follows: Add caprylic / capric triglyceride and hydrogenated polyisobutene to a stirring tank, stir at 150-250 rpm for 4-6 minutes after starting, then add Ganoderma lucidum extract, ginseng root extract, peony extract, and snow lotus extract in sequence, maintain the speed unchanged, and stir for 3 minutes after adding each extract, then add pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), stir for 4-6 minutes, homogenize at 3500-4500 rpm for 1.5-2.5 minutes, and filter with a 200-mesh filter cloth to obtain the plant-based nourishing oil.

6. The mussel bionic sebum repair oil according to claim 5, characterized in that: The raw materials of the plant-based nourishing oil include, by mass percentage, 18-20% hydrogenated polyisobutene, 5-7% ganoderma lucidum extract, 2-4% ginseng root extract, 2-4% peony extract, 0.4-0.6% snow lotus extract, 0.13-0.17% pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate) ester and the remainder caprylic / capric triglyceride.

7. The mussel bionic sebum repair oil according to claim 1, characterized in that: The preparation method of the soothing oil is: Mix hexyldecanol and stearic acid and heat to 58-62°C, stir until completely dissolved to obtain a mixture, add bisabolol to the mixture, stir at 50-150 rpm for 4-6 minutes, cool to 39-41°C and add N-palmitoyl hydroxyproline cetyl ester, keep the speed unchanged and stir evenly, cool to room temperature and add rapeseed sterols, stir evenly and homogenize at 2500-3500 rpm for 2-4 minutes, and filter with 200 mesh filter cloth to obtain soothing oil.

8. The mussel bionic sebum repair oil according to claim 7, characterized in that: The raw materials of the soothing oil include, by mass percentage, 2-3% of bisabolol, 2-3% of N-palmitoyl hydroxyproline cetyl ester, 2-3% of stearic acid, 0.3-0.7% of rape sterols and the balance of hexyldecanol.

9. The mussel biomimetic sebum repair oil according to claim 1, characterized in that: The light oil comprises, by mass percentage, 88-92% C9-12 alkane and the remainder coconut oil alcohol-caprylate / caprate; the antioxidant comprises, by mass percentage, 65-75% vitamin E and the remainder sunflower seed oil; the ceramide is prepared by mixing 2.8-3.2% ceramide NP by mass and the remainder isostearyl alcohol and stirring the mixture in a 55°C water bath until the mixture is completely dissolved.

10. A method for preparing the mussel bionic sebum repair oil according to any one of claims 1 to 9, characterized in that: The preparation method comprises the following steps: At room temperature, hydrogenated polyisobutene, mussel oil, pine seed oil, meadowfoam seed oil, baobab seed oil, marula oil, plant extract oil, plant extract nourishing oil, soothing oil, light oil, squalane, ceramide and antioxidant are added to the oil phase pot in proportion, mixed evenly and discharged, and homogenized at a speed of 5000-8000rpm for 6-8min to obtain mussel bionic sebum repair oil.

Images