Traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition which is composed of salvia miltiorrhiza, ligusticum wallichii, pseudo-ginseng, pinellia ternate, pericarpium citri reticulatae, poria cocos, radix bupleuri, rhizoma cyperi, astragalus membranaceus, American ginseng, semen boitae, polygala tenuifolia, nattokinase, earthworm protein, red yeast rice, semen cassiae, Chinese yam and hawthorn, and discloses a preparation method of the traditional Chinese medicine composition. The medicine has the functions of tonifying qi and yin, tranquilizing mind by nourishing the heart, lowering lipid, resisting inflammation, strengthening the spleen and stomach and the like, thereby achieving the purpose of preventing cardiovascular and cerebrovascular diseases.

Description

Technical Field

[0001] The present invention relates to the technical field of cardiovascular and cerebrovascular drugs, and more specifically to a traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases and its preparation method. Background Art

[0002] Phlegm stasis is a pathological product in traditional Chinese medicine theory, referring to the state in which phlegm dampness formed by abnormal metabolism of body fluids in the body combines with blood stasis formed by unsmooth blood circulation. The accumulation of phlegm stasis in the body is likely to cause various diseases, such as cardiovascular and cerebrovascular diseases, respiratory diseases, tumors, and metabolic diseases. The formation of phlegm stasis is related to various factors such as constitution, diet, emotions, and environment. If not adjusted in time, it may pose a serious threat to health.

[0003] The accumulation of phlegm stasis in the body will first affect the qi and blood circulation, leading to disharmony of zang-fu functions. In the cardiovascular and cerebrovascular system, phlegm stasis may cause diseases such as coronary heart disease, cerebral infarction, and hypertension. Phlegm stasis blocks the heart vessels, resulting in insufficient myocardial blood supply, presenting symptoms such as chest tightness and palpitations; phlegm stasis blocks the brain collaterals, which may cause dizziness, headache, and even stroke.

[0004] Existing traditional Chinese medicine compounds for preventing cardiovascular and cerebrovascular diseases mostly focus on a single pathogenesis (such as promoting blood circulation to remove blood stasis or resolving phlegm and dredging collaterals), and it is difficult to take into account the complex pathological states of phlegm, stasis, and qi stagnation. Traditional classical prescriptions (such as Xuefu Zhuyu Decoction and Erchen Decoction) have the following deficiencies: they focus on treating existing diseases and have insufficient preventive intervention for sub-healthy states; they do not systematically integrate the multi-dimensional regulation mechanism of "qi-blood-collateral"; they lack optimized design for the constitution of phlegm stasis transforming into heat and liver depression and spleen deficiency in modern people. Summary of the Invention

[0005] In view of this, the present invention provides a traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases and its preparation method.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases contains components for promoting blood circulation to remove blood stasis, specifically: 15 parts of Salvia miltiorrhiza, 10 parts of Ligusticum chuanxiong, and 8 parts of Panax notoginseng.

[0008] The traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases further contains components for regulating qi and resolving phlegm, strengthening the spleen and promoting diuresis, specifically: 12 parts of Pinellia ternata, 8 parts of Citrus reticulata Blanco, and 10 parts of Poria cocos.

[0009] The traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases further contains components for soothing the liver and regulating qi, regulating the pivot mechanism, specifically: 12 parts of Bupleurum chinense and 8 parts of Cyperus rotundus.

[0010] The traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases further contains components for supplementing qi and nourishing yin, specifically: 20 parts of Astragalus membranaceus and 10 parts of American ginseng.

[0011] The traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases further contains a component for nourishing the heart and calming the mind, specifically: 15 parts of semen platycladi and 10 parts of polygala tenuifolia.

[0012] The traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases further contains a component for dissolving thrombus and softening blood vessels, specifically: 15 parts of nattokinase and 5 parts of earthworm protein.

[0013] The traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases further contains a component for reducing lipid and anti-inflammation, specifically: 10 parts of monascus purpureus and 8 parts of cassia seed.

[0014] The traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases further contains a component for strengthening the spleen and regulating the stomach, specifically: 30 parts of Chinese yam and 10 parts of hawthorn.

[0015] The application of the traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases in the preparation of drugs for preventing cardiovascular and cerebrovascular diseases, and the cardiovascular and cerebrovascular diseases belong to the type of mutual binding of phlegm and stasis, qi stagnation and collateral obstruction.

[0016] The preparation method of the traditional Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases comprises the following steps:

[0017] (1) Take salvia miltiorrhiza, ligusticum wallichii, notoginseng, tangerine peel, bupleurum chinense, and cyperus rotundus, and extract the volatile oil by supercritical extraction method, and include it with cyclodextrin;

[0018] (2) Take the medicinal residues after supercritical extraction of salvia miltiorrhiza, ligusticum wallichii, notoginseng, tangerine peel, bupleurum chinense, and cyperus rotundus, mix them with pinellia ternata, poria cocos, astragalus membranaceus, american ginseng, semen platycladi, polygala tenuifolia, monascus purpureus, cassia seed, Chinese yam, and hawthorn, extract twice with water for 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray dry after concentration;

[0019] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin clathrate obtained in step (1), add nattokinase and earthworm protein, and prepare into one of an aqueous solution, powder, granule, tablet, capsule, and pill.

[0020] Beneficial effects:

[0021] 1. Cardiovascular and cerebrovascular diseases are called heart arthralgia in Chinese medical theory. The present invention is composed of salvia miltiorrhiza, chuanxiong, notoginseng, pinellia tuber, dried orange peel, tuckahoe, bupleurum, cyperus rotundus, astragalus, American ginseng, cypress seed, polygala, nattokinase, earthworm protein, red yeast rice, cassia seed, yam, and hawthorn. The heart governs blood vessels. If due to insufficient heart qi, the heart yang is not vigorous, yang qi cannot agitate blood circulation and blood stasis in the heart; or due to invasion of cold pathogens, coldness condenses, and blood circulation is not smooth or even blocked; or due to the development of arthralgia, "pulse arthralgia is endless, and it is affected by evil again, and it is placed in the heart" (Suwen·Arthralgia Theory) and becomes heart arthralgia, which can all cause heart artery stasis and cause palpitations. Phlegm and fluid retention can also cause cardiovascular and cerebrovascular diseases, such as "Golden Chamber Synopsis" that mentions the palpitations caused by water and fluid retention, and "Danxi Heart Method", "Blood Symptom Theory" etc. also talk about the palpitations caused by turbid phlegm. "Blood Symptoms and Palpitations" says: "If there is phlegm in the heart, the phlegm enters the heart and blocks the heart qi, so the heartbeat is uneasy." As for the reasons for the accumulation of phlegm and fluid, there are roughly the following aspects. Insufficient heart blood, such as "Zhengzhi Huibu·Jingji Zhengpao" says: "Once the heart blood is deficient, the spirit and qi are lost, the spirit is gone, the body is empty, the body is empty, and the phlegm is accumulated. Phlegm is in the heart, which is the reason for palpitations"; spleen and kidney yang deficiency, kidney yang deficiency, opening and closing are not functioning properly, bladder qi transformation is not good, the spleen loses its healthy transportation, and the transfer is lost, then dampness and turbidity are accumulated inside, spleen and kidney yang deficiency cannot evaporate water, and accumulates into fluid, cold fluid is forced up, heart yang is suppressed, and palpitations occur; fire and heat are depressed inside, boiling body fluids and forming phlegm and turbidity. For example, "Yi Zong Must Read·Palpitations" believes that palpitations "have different symptoms, but they are all caused by heart injury and fire movement, and fire depression and salivation." The spleen is responsible for transporting and transforming water and dampness. If the spleen is deficient, the transportation and transformation are abnormal, resulting in the internal generation of dampness and turbidity. Dampness gathers into phlegm for a long time, and phlegm and blood stasis can block the meridians and cause cardiovascular and cerebrovascular diseases. The spleen-strengthening and dampness-draining method reduces the generation of phlegm and dampness by restoring the spleen's transportation and transformation function, thereby reducing blood viscosity and improving blood circulation. The present invention adopts salvia miltiorrhiza and chuanxiong to promote blood circulation and dissipate blood stasis, Panax notoginseng to dissipate blood stasis without hurting the body, Pinellia tuber and dried orange peel to regulate qi and resolve phlegm, and Poria cocos to strengthen the spleen and penetrate dampness, with salvia miltiorrhiza, chuanxiong, Panax notoginseng, Pinellia tuber, dried orange peel, and Poria cocos as the main medicine; Chinese medicine believes that "qi is the commander of blood, and blood is the mother of qi", and the prevention and treatment of cardiovascular and cerebrovascular diseases also starts with qi and blood, Bupleurum chinense soothes the liver and relieves depression, and is mainly used for qi stagnation in the heart, abdomen, intestines and stomach, food accumulation, cold and heat evil qi, and the old is replaced by the new, and Cyperus rotundus soothes the liver and relieves pain, eliminates accumulation and resolves stagnation, and Bupleurum chinense and Cyperus rotundus are ministerial medicines; Chinese medicine believes that the heart governs blood vessels and relies on the promotion of qi and the nourishment of yin fluid. Qi deficiency leads to weak propulsion, slow blood flow, and easy blood stasis; Yin deficiency leads to insufficient body fluid, viscous blood, and increased risk of blood stasis. Astragalus and American ginseng are used to nourish qi and yin; "The heart governs the mind", and a stable mind is the basis for maintaining the normal operation of qi and blood. Malnutrition of the mind or hyperactivity of heart fire can lead to palpitations, insomnia, and blood pressure fluctuations, which in turn affect the blood supply to the heart and brain, so cypress seeds and polygala are used to nourish the heart and calm the mind; nattokinase and earthworm protein dissolve blood clots and soften blood vessels; "phlegm turbidity" is the core pathogenesis of abnormal lipid metabolism.Long-term improper diet (such as high-fat and high-sugar diet) and spleen deficiency with loss of transportation function can lead to endogenous phlegm-dampness. Phlegm-turbidity blocks the collaterals, forming atherosclerosis. Therefore, red yeast rice and cassia seed are used to reduce lipid and inflammation; astragalus membranaceus, american ginseng, semen platycladi, polygala tenuifolia, nattokinase, earthworm protein, red yeast rice and cassia seed are used as adjuvant drugs in total; yam and hawthorn invigorate the spleen and harmonize the stomach and are used as guiding drugs. The whole formula aims to prevent cardiovascular and cerebrovascular diseases by "treating phlegm and stasis simultaneously, regulating qi and collaterals together", taking into account supplementing qi and nourishing yin, nourishing the heart and calming the mind, reducing lipid and inflammation, and invigorating the spleen and harmonizing the stomach.

[0022] 2. Innovation in treatment principles: The present invention proposes the core treatment principle of "treating phlegm and stasis simultaneously, regulating qi and collaterals together": Treating phlegm and stasis simultaneously: Synchronously resolve the adhesive state of phlegm-turbidity and blood stasis, and block the vicious cycle of "phlegm-turbidity generating blood stasis, blood stasis blocking generating phlegm-turbidity" (recorded in "Danxi's Methods of Treatment" that "phlegm and stasis share the same origin"). Regulating qi and collaterals together: Promote qi movement and relieve depression to smooth qi mechanism, and use the collateral dredging method to repair the microvascular endothelial function (recorded in "Medical Records of Clinical Practice Guidelines" that "in the initial stage of the disease, it is in qi, and in the long-term disease, it enters the collaterals").

[0023] 3. Innovation in components: It contains drugs for qi aspect: Soothing the liver and regulating qi, regulating the pivot mechanism smoothly (such as bupleurum chinense and cyperus rotundus); drugs for blood aspect: Promoting blood circulation to remove blood stasis, improving microcirculation (such as salvia miltiorrhiza and notoginseng); drugs for collateral aspect: Resolving phlegm and dredging collaterals, protecting vascular endothelium (such as earthworm). The three have a synergistic effect. Detailed implementation manners

[0024] The present invention will be further described below in conjunction with the detailed implementation manners. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that after reading the content recorded in the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms also fall within the scope defined by the appended claims of this application.

[0025] Example 1:

[0026] Take 150 g of salvia miltiorrhiza, 100 g of ligusticum wallichii, and 80 g of notoginseng. The preparation method includes the following steps:

[0027] (1) Take salvia miltiorrhiza, ligusticum wallichii, and notoginseng and extract the volatile oil by the supercritical extraction method, and include it with cyclodextrin;

[0028] (2) Take the medicinal residues after supercritical extraction of salvia miltiorrhiza, ligusticum wallichii, and notoginseng, extract with water twice, each time for 2 hours, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray dry after concentration;

[0029] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin inclusion complex obtained in step (1), and prepare into granules.

[0030] Example 2:

[0031] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, and 100 g of Poria cocos. The preparation method includes the following steps:

[0032] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, and Citrus reticulata Blanco, and extract the volatile oil by supercritical extraction method, and include it with cyclodextrin;

[0033] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, and Citrus reticulata Blanco, mix them with Pinellia ternata and Poria cocos, extract with water twice, 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray dry after concentration;

[0034] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin clathrate obtained in step (1), and prepare into granules.

[0035] Example 3:

[0036] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, and 80 g of Cyperus rotundus. The preparation method includes the following steps:

[0037] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by supercritical extraction method, and include it with cyclodextrin;

[0038] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata and Poria cocos, extract with water twice, 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray dry after concentration;

[0039] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin clathrate obtained in step (1), and prepare into granules.

[0040] Example 4:

[0041] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, 80 g of Cyperus rotundus, 200 g of Astragalus membranaceus, and 100 g of American ginseng. The preparation method includes the following steps:

[0042] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by supercritical extraction method, and include it with cyclodextrin;

[0043] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata, Poria cocos, Astragalus membranaceus, and American ginseng, extract with water twice, 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray dry after concentration;

[0044] (3) Take the spray-dried powder obtained in step (2), and add the cyclodextrin clathrate obtained in step (1) to prepare a granule.

[0045] Example 5:

[0046] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, 80 g of Cyperus rotundus, 200 g of Astragalus membranaceus, 100 g of American ginseng, 150 g of Platycladus orientalis seed, and 100 g of Polygala tenuifolia. The preparation method includes the following steps:

[0047] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by supercritical extraction, and include it with cyclodextrin;

[0048] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata, Poria cocos, Astragalus membranaceus, American ginseng, Platycladus orientalis seed, and Polygala tenuifolia, extract with water twice, each time for 2 hours, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate the ethanol, and spray-dry after concentration;

[0049] (3) Take the spray-dried powder obtained in step (2), and add the cyclodextrin clathrate obtained in step (1) to prepare a granule.

[0050] Example 6:

[0051] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, 80 g of Cyperus rotundus, 200 g of Astragalus membranaceus, 100 g of American ginseng, 150 g of Platycladus orientalis seed, 100 g of Polygala tenuifolia, 150 g of nattokinase, and 50 g of earthworm protein. The preparation method includes the following steps:

[0052] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by supercritical extraction, and include it with cyclodextrin;

[0053] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata, Poria cocos, Astragalus membranaceus, American ginseng, Platycladus orientalis seed, and Polygala tenuifolia, extract with water twice, each time for 2 hours, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate the ethanol, and spray-dry after concentration;

[0054] (3) Take the spray-dried powder obtained in step (2), and add the cyclodextrin clathrate obtained in step (1), add nattokinase and earthworm protein, and prepare a granule.

[0055] Example 7:

[0056] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, 80 g of Cyperus rotundus, 200 g of Astragalus membranaceus, 100 g of American ginseng, 150 g of Semen platycladi, 100 g of Polygala tenuifolia, 150 g of nattokinase, 50 g of earthworm protein, 100 g of Monascus purpureus, and 80 g of Cassia obtusifolia. The preparation method comprises the following steps:

[0057] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by the supercritical extraction method, and include it with cyclodextrin;

[0058] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata, Poria cocos, Astragalus membranaceus, American ginseng, Semen platycladi, Polygala tenuifolia, Monascus purpureus, and Cassia obtusifolia, extract twice with water for 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray-dry after concentration;

[0059] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin clathrate obtained in step (1), add nattokinase and earthworm protein, and prepare into granules.

[0060] Example 8:

[0061] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, 80 g of Cyperus rotundus, 200 g of Astragalus membranaceus, 100 g of American ginseng, 150 g of Semen platycladi, 100 g of Polygala tenuifolia, 150 g of nattokinase, 50 g of earthworm protein, 100 g of Monascus purpureus, 80 g of Cassia obtusifolia, 300 g of Dioscorea opposita, and 100 g of Crataegus pinnatifida. The preparation method comprises the following steps:

[0062] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by the supercritical extraction method, and include it with cyclodextrin;

[0063] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata, Poria cocos, Astragalus membranaceus, American ginseng, Semen platycladi, Polygala tenuifolia, Monascus purpureus, Cassia obtusifolia, Dioscorea opposita, and Crataegus pinnatifida, extract twice with water for 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray-dry after concentration;

[0064] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin clathrate obtained in step (1), add nattokinase and earthworm protein, and prepare into granules.

[0065] Example 9:

[0066] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, 80 g of Cyperus rotundus, 200 g of Astragalus membranaceus, 100 g of American ginseng, 150 g of Semen platycladi, 100 g of Polygala tenuifolia, 150 g of nattokinase, 50 g of earthworm protein, 100 g of Monascus purpureus, 80 g of Cassia obtusifolia, 300 g of Dioscorea opposita, 100 g of Crataegus pinnatifida. The preparation method includes the following steps:

[0067] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by supercritical extraction method, and include it by cyclodextrin inclusion;

[0068] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata, Poria cocos, Astragalus membranaceus, American ginseng, Semen platycladi, Polygala tenuifolia, Monascus purpureus, Cassia obtusifolia, Dioscorea opposita, and Crataegus pinnatifida, extract twice with water for 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray-dry after concentration;

[0069] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin inclusion complex obtained in step (1), add nattokinase and earthworm protein, and prepare into tablets.

[0070] Example 10:

[0071] Take 150 g of Salvia miltiorrhiza, 100 g of Ligusticum chuanxiong, 80 g of Panax notoginseng, 120 g of Pinellia ternata, 80 g of Citrus reticulata Blanco, 100 g of Poria cocos, 120 g of Bupleurum chinense, 80 g of Cyperus rotundus, 200 g of Astragalus membranaceus, 100 g of American ginseng, 150 g of Semen platycladi, 100 g of Polygala tenuifolia, 150 g of nattokinase, 50 g of earthworm protein, 100 g of Monascus purpureus, 80 g of Cassia obtusifolia, 300 g of Dioscorea opposita, 100 g of Crataegus pinnatifida. The preparation method includes the following steps:

[0072] (1) Take Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, and extract the volatile oil by supercritical extraction method, and include it by cyclodextrin inclusion;

[0073] (2) Take the medicinal residues after supercritical extraction of Salvia miltiorrhiza, Ligusticum chuanxiong, Panax notoginseng, Citrus reticulata Blanco, Bupleurum chinense, and Cyperus rotundus, mix them with Pinellia ternata, Poria cocos, Astragalus membranaceus, American ginseng, Semen platycladi, Polygala tenuifolia, Monascus purpureus, Cassia obtusifolia, Dioscorea opposita, and Crataegus pinnatifida, extract twice with water for 2 hours each time, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate ethanol, and spray-dry after concentration;

[0074] (3) Take the spray-dried powder obtained in step (2), add the cyclodextrin inclusion complex obtained in step (1), add nattokinase and earthworm protein, and prepare into capsules.

[0075] Example 11: Evaluation of the lipid-lowering effect of different traditional Chinese medicine compositions of the present invention

[0076] 220 Kunming mice (weighing 18 - 22 g) were selected and randomly divided into a blank group, a model group, a simvastatin group, and groups of Examples 1 - 8, with 20 mice in each group. The blank group was fed a basal diet, and the remaining groups were given a high-fat diet formula: (77.5% basal diet, 2% cholesterol, 10% lard, 10% egg yolk powder, 0.5% sodium deoxycholate). After one week of high-fat diet, gavage was performed once a day at the same time at a volume of 10 mL / kg. The blank and model groups were gavaged with an equal volume of normal saline and continuously fed for 5 weeks. The simvastatin group was given a dose of 10 mg / kg, and the groups of Examples 1 - 8 were given the granules prepared in Examples 1 - 8 at a dose of 10 g crude drug / kg. After the end of the 8th week, all mice were fasted for 12 h without water deprivation, blood was collected from the eye socket into a centrifuge tube, and centrifuged (3000 r / min, 4 °C) to separate the serum. According to the detection requirements of the kit, the contents of total cholesterol (TC) and triglyceride (TG) in the serum were measured, and the measurement results are shown in Table 1.

[0077] Table 1 Contents of TC and TG in the serum of hyperlipidemic mice for different compositions

[0078] Group TC (mmol / L) TG (mmol / L) Blank group 3.12±0.25 1.98±0.34 Model group <![CDATA[6.76±1.48 ## > <![CDATA[5.36±0.87 ## > Simvastatin group <![CDATA[4.28±1.63 * > <![CDATA[3.62±0.49 * > Example 1 6.09±1.42 5.21±0.68 Example 2 5.46±1.75 4.76±0.53 Example 3 5.12±1.47 4.64±0.87 Example 4 4.84±0.97 3.51±0.47 Example 5 <![CDATA[4.56±1.32 * > <![CDATA[3.65±0.43 * > Example 6 <![CDATA[4.43±0.62 * > <![CDATA[3.76±0.59 * > Example 7 <![CDATA[3.98±0.52 * > <![CDATA[4.09±0.73 * > Example 8 <![CDATA[3.27±0.39 ** > <![CDATA[2.08±0.53 ** >

[0079] (Compared with the blank group, ## P < 0.01, compared with the model group * P < 0.05, ** P < 0.01)

[0080] The results showed that the levels of TC and TG in the hyperlipidemic model group were significantly higher than those in the blank group, indicating that the hyperlipidemia model of mice was successfully established; compared with the model group, the compositions of Examples 5 - 8 of the present invention could significantly reduce the levels of TC and TG in the serum, and Example 8 had a better effect, indicating that the compositions of the present invention had a good lipid-lowering effect. Since hyperlipidemia refers to an increase in the levels of cholesterol or triglyceride in the plasma, hyperlipidemia is mainly related to cholesterol, and the increase in cholesterol is one of the most important risk factors for the increase in the mortality rate of cardiovascular and cerebrovascular diseases such as coronary heart disease. The traditional Chinese medicine composition of the present invention can effectively reduce the contents of TC and TG in the serum of hyperlipidemic mice, indicating that the traditional Chinese medicine composition of the present invention has a good effect in preventing cardiovascular and cerebrovascular diseases.

[0081] Example 10: Research on different blood viscosity reduction of the present invention

[0082] 88 SPF-grade SD rats, weighing 180-200 g and being male, were randomly divided into a blank group, a model group, a positive control group, and groups of Examples 1-8, with 8 rats in each group. The groups of Examples 1-8 were intragastrically administered the granules prepared in Examples 1-8 at a dose of 10 g crude drug amount / kg, the positive control group was intragastrically administered simvastatin at a dose of 20 mg / kg, once a day for 14 consecutive days, and the blank control group and the model group were intragastrically administered an equal volume of normal saline. 30 min after the last administration, the rats were anesthetized by intraperitoneal injection of pentobarbital sodium (50 mg / kg). Except for the blank group, in each group, 10% dextran (0.6 g / kg) in normal saline was rapidly injected into the sublingual vein. 1 h after the injection, blood was taken from the abdominal aorta to measure the whole blood viscosity of the rats' blood. The results are shown in Table 2.

[0083] Table 2 Effects of different compositions on the whole blood viscosity of model rats

[0084]

[0085] (Compared with the blank group, ## P<0.01, compared with the model group * P<0.05, ** P<0.01)

[0086] Results showed that compared with the blank group, the whole blood viscosity of rats in the model group was significantly increased at different shear rates (P < 0.05), indicating successful modeling. At the same time, compared with the model group, the whole blood viscosity of rats in Example 6-8 groups and the positive control group was significantly decreased at different shear rates (P < 0.05), and the effect of Example 8 was the best, indicating that the traditional Chinese medicine composition of the present invention and the positive drug can both reduce blood viscosity and improve blood circulation. High blood viscosity can slow down the blood flow velocity, resulting in insufficient blood supply to all parts of the body. Slow blood flow will affect the delivery of oxygen and nutrients, thereby causing symptoms such as fatigue and dizziness. Prolonged poor blood circulation may also affect cell metabolism, leading to a decline in tissue function. High blood viscosity will increase the burden on the heart and blood vessels, resulting in elevated blood pressure. The heart needs to exert greater force to push blood flow, and in the long run, this may cause diseases such as myocardial hypertrophy and heart failure. At the same time, the increased pressure on the blood vessel wall is likely to cause blood vessel damage, increasing the risk of arteriosclerosis and stroke. High blood viscosity will make platelets and fibrin in the blood more likely to aggregate and form thrombi. Thrombi may block blood vessels, leading to local tissue ischemia and necrosis. If a thrombus detaches and flows with the blood, it may cause serious diseases such as pulmonary embolism and cerebral infarction, endangering life. High blood viscosity will affect the blood supply to important organs such as the heart, brain, and kidneys. Insufficient organ blood supply may lead to a decline in function and even organ failure. For example, myocardial ischemia may cause angina or myocardial infarction, and insufficient cerebral blood supply may lead to memory decline or brain dysfunction. It will promote the deposition of lipids on the blood vessel wall and accelerate the process of arteriosclerosis. Arteriosclerosis will reduce the elasticity of blood vessels and narrow the lumen, further aggravating blood circulation disorders. Arteriosclerosis may also cause chronic diseases such as hypertension and coronary heart disease, seriously affecting the quality of life. The traditional Chinese medicine composition of the present invention can effectively reduce blood viscosity and improve blood circulation, indicating that the traditional Chinese medicine composition of the present invention has good effects in preventing cardiovascular and cerebrovascular diseases.

[0087] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made therein without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases, characterized in that: Contains blood-activating and blood-stasis-removing ingredients, specifically: 15 parts of Salvia miltiorrhiza, 10 parts of Chuanxiong, and 8 parts of Panax notoginseng.

2. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 1, characterized in that: It also contains ingredients that regulate qi and resolve phlegm, strengthen the spleen and eliminate dampness, specifically: 12 parts of Pinellia, 8 parts of Tangerine Peel, and 10 parts of Poria.

3. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 2, characterized in that: It also contains ingredients that soothe the liver and regulate qi, and regulate the key organs, specifically: 12 parts of bupleurum and 8 parts of cyperus.

4. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 3, characterized in that: It also contains ingredients that replenish qi and nourish yin, specifically: 20 parts of astragalus and 10 parts of American ginseng.

5. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 4, characterized in that: It also contains ingredients that nourish the heart and calm the mind, specifically: 15 parts of pine nuts and 10 parts of polygala.

6. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 5, characterized in that: It also contains components that can dissolve blood clots and soften blood vessels, specifically: 15 parts of nattokinase and 5 parts of earthworm protein.

7. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 6, characterized in that: It also contains lipid-lowering and anti-inflammatory ingredients, specifically: 10 parts of red yeast rice and 8 parts of cassia seed.

8. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 7, characterized in that: It also contains ingredients that strengthen the spleen and stomach, specifically: 30 parts of yam and 10 parts of hawthorn.

9. Use of the Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases as claimed in claim 8 in preparing drugs for preventing cardiovascular and cerebrovascular diseases, characterized in that: Cardiovascular and cerebrovascular diseases belong to the type of phlegm and blood stasis, and qi stagnation and obstruction of the collaterals.

10. The Chinese medicine composition for preventing cardiovascular and cerebrovascular diseases according to claim 8, characterized in that: The preparation method comprises the following steps: (1) extracting volatile oil from salvia miltiorrhiza, chuanxiong, notoginseng, dried orange peel, bupleurum and cyperus rotundus by supercritical extraction, and encapsulating with cyclodextrin; (2) Mix the residues of Danshen, Chuanxiong, Panax notoginseng, dried orange peel, Bupleurum, and Cyperus rotundus after supercritical extraction with Pinellia, Poria, Astragalus, American ginseng, Platycladus seed, Polygala, Monascus, Cassia seed, Dioscorea opposita, and Crataegus pinnatifida, extract twice with water, each time for 2 hours, combine the filtrates, concentrate, precipitate with alcohol, collect the supernatant, evaporate the ethanol, concentrate, and spray-dry after extraction; (3) taking the spray-dried powder obtained in step (2), adding the cyclodextrin inclusion compound obtained in step (1), adding nattokinase and earthworm protein, and preparing one of the following: an aqueous solution, a powder, a granule, a tablet, a capsule, or a pill.

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