Blood pressure monitoring control device and method based on microporous electrode ion phoresis effect

Abstract

The invention discloses a blood pressure monitoring control device and method based on a microporous electrode ionophoresis effect, and belongs to the technical field of blood pressure monitoring. The single-chip microcomputer system module is used for receiving the pulse wave signals and the electrocardiosignals and calculating blood pressure indexes; the signal transmission module is used for transmitting the pulse wave signal, the electrocardiosignal and the blood pressure calculation result to the mobile terminal and receiving a medicine delivery control instruction; the drug delivery module is used for delivering blood pressure treatment drugs through the microporous electrode ionophoresis effect. By collecting the pulse wave signal and the electrocardiosignal in real time and calculating the blood pressure index in real time, dynamic monitoring of the blood pressure index of the user can be achieved, when the blood pressure index is abnormal, according to the medicine delivery control instruction issued by the mobile terminal, through the micropore electrode ion electrophoresis effect, medicine delivery treatment can be automatically conducted through the medicine delivery module, and the treatment efficiency is improved. The blood pressure of the user can be safely and accurately regulated and controlled, and the use experience of the user is improved.

Description

Technical Field

[0001] The present application relates to the technical field of blood pressure monitoring, and particularly to a blood pressure monitoring and control device and method based on the ionophoresis effect of microporous electrodes. Background Art

[0002] Currently, due to the changes in people's lifestyles, cardiovascular diseases have become high-incidence diseases in modern society, and hypertension is the primary risk factor for cardiovascular and cerebrovascular diseases, with characteristics such as being difficult to control, having a high incidence of cardiovascular, cerebrovascular, and renal complications, and a high mortality rate.

[0003] In related technologies, conventional clinic blood pressure and ambulatory blood pressure measurements are achieved by cuff pressurization. Methods for treating hypertension usually include oral administration and sublingual administration. However, in practical applications, it has been found that the method of measuring blood pressure by cuff pressurization cannot monitor blood pressure frequently over a long period, making it difficult to meet the needs of hypertension diagnosis and early warning. Moreover, existing treatment methods lack a more automated drug delivery method that requires little manual intervention.

[0004] In summary, the technical problems existing in related technologies need to be improved. Summary of the Invention

[0005] The embodiments of the present application provide a blood pressure monitoring and control device and method based on the ionophoresis effect of microporous electrodes, which can achieve dynamic monitoring of the user's blood pressure indicators. It can also automatically administer drugs through the ionophoresis effect of microporous electrodes, helping to safely and accurately regulate the user's blood pressure and improve the user experience.

[0006] On the one hand, the embodiments of the present application provide a blood pressure monitoring and control device based on the ionophoresis effect of microporous electrodes. The device includes: a signal acquisition module, a signal modulation module, a single-chip microcomputer system module, a signal transmission module, and a drug delivery module;

[0007] The signal acquisition module is used to acquire signals. The signal acquisition module includes a pulse acquisition module for acquiring pulse wave signals and an electrocardiogram acquisition module for acquiring electrocardiogram signals;

[0008] The signal modulation module is wirelessly communicatively connected to the signal acquisition module and is used to perform signal processing on the acquired signals;

[0009] The single-chip microcomputer system module is used to receive the processed pulse wave signals and electrocardiogram signals; it is also used to calculate blood pressure indicators based on the processed pulse wave signals and electrocardiogram signals;

[0010] The signal transmission module is used to transmit the processed pulse wave signals, electrocardiogram signals, and blood pressure indicator calculation results to the mobile terminal; it is also used to receive the drug delivery control instructions issued by the mobile terminal;

[0011] The drug delivery module is used to deliver blood pressure treatment drugs through the iontophoresis effect of microporous electrodes.

[0012] Optionally, the pulse acquisition module includes: a polyester substrate and a micro-nano needle structure;

[0013] A metal conductive layer is deposited on the polyester substrate;

[0014] The micro-nano needle structure includes a first micro-needle structure prepared from a polydimethylsiloxane substrate, a zinc oxide layer nano-needle structure is grown on the surface of the first micro-needle structure, and a metal conductive layer is deposited on the surface of the zinc oxide layer nano-needle structure.

[0015] Optionally, the electrocardiogram acquisition module is encapsulated and integrated by at least one second micro-needle structure;

[0016] The second micro-needle structure is prepared from a polydimethylsiloxane substrate; a metal conductive layer is deposited on the surface of the second micro-needle structure.

[0017] Optionally, the drug delivery module includes a working electrode end micro-needle structure and a counter electrode end micro-needle structure;

[0018] The working electrode end micro-needle structure includes a hydrogel substrate containing a blood pressure treatment drug, a flexible gold electrode is embedded on one side of the hydrogel substrate, and a micro-needle structure with mesopores is formed on the other side of the hydrogel substrate;

[0019] The counter electrode end micro-needle structure includes a hydrogel substrate, a flexible gold electrode is embedded on one side of the hydrogel substrate, and a micro-needle structure with mesopores is formed on the other side of the hydrogel substrate.

[0020] On the other hand, the embodiment of the present application provides a blood pressure monitoring and control method based on the iontophoresis effect of microporous electrodes. The method includes the following steps:

[0021] Collect pulse wave signals and electrocardiogram signals;

[0022] Perform signal processing on the pulse wave signals and the electrocardiogram signals, so as to calculate blood pressure indicators according to the pulse wave signals and electrocardiogram signals after signal processing;

[0023] Transmit the pulse wave signals and electrocardiogram signals after signal processing and the calculation results of blood pressure indicators to the mobile terminal, and receive the drug delivery control instructions issued by the mobile terminal;

[0024] Determine the opening and closing state of the drug delivery module according to the drug delivery control instructions;

[0025] Among them, the pulse wave signal is collected by a pulse acquisition module, and the electrocardiogram signal is collected by an electrocardiogram acquisition module; when the drug delivery module is in an open state, a blood pressure treatment drug is delivered through the iontophoresis effect of the microelectrode.

[0026] Optionally, the pulse acquisition module is prepared through the following steps:

[0027] A first microneedle structure is prepared on a flexible polydimethylsiloxane substrate through photolithography and centrifugal casting;

[0028] A zinc oxide layer nanoneedle structure is grown on the surface of the first microneedle structure through a hydrothermal growth method;

[0029] A metal conductive layer is deposited on the surface of the zinc oxide layer nanoneedle structure through magnetron sputtering to obtain a micro-nanoneedle structure;

[0030] A metal conductive layer is deposited on a polyester substrate through magnetron sputtering to obtain a prepared polyester substrate;

[0031] The micro-nanoneedle structure and the prepared polyester substrate are encapsulated to obtain the pulse acquisition module.

[0032] Optionally, the electrocardiogram acquisition module is prepared through the following steps:

[0033] A second microneedle structure is prepared on a flexible polydimethylsiloxane substrate through photolithography and centrifugal casting;

[0034] A metal conductive layer is deposited on the surface of the second microneedle structure through magnetron sputtering;

[0035] The substrate of the second microneedle structure is insulated to obtain a microneedle electrode;

[0036] At least one of the microneedle electrodes is encapsulated and integrated to obtain an electrocardiogram acquisition module.

[0037] Optionally, the drug delivery module is prepared through the following steps:

[0038] A microneedle structure mold is prepared through photolithography and centrifugal casting;

[0039] A microneedle structure is prepared through polyethylene glycol diacrylate and the microneedle structure mold, zinc oxide nanowires are doped at the tip of the microneedle structure, and the tip of the microneedle structure is immersed in an acidic solution to dissolve the zinc oxide nanowires to form mesopores, obtaining a microneedle structure with mesopores;

[0040] A hydrogel substrate is prepared through polyethylene glycol diacrylate, and a blood pressure treatment drug is loaded inside the hydrogel substrate;

[0041] Embed a flexible gold electrode into the hydrogel substrate and perform a demolding process to obtain the micro-needle structure at the working electrode end;

[0042] Prepare a micro-needle structure mold through photolithography and centrifugal casting;

[0043] Prepare a micro-needle structure using polyethylene glycol diacrylate and the micro-needle structure mold, incorporate zinc oxide nanowires at the tip of the micro-needle structure, and immerse the tip of the micro-needle structure in an acidic solution to dissolve the zinc oxide nanowires, forming mesopores to obtain a micro-needle structure with mesopores;

[0044] Prepare a hydrogel substrate using polyethylene glycol diacrylate, embed a flexible gold electrode into the hydrogel substrate, and perform a demolding process to obtain the micro-needle structure at the counter electrode end;

[0045] Package the micro-needle structure at the working electrode end and the micro-needle structure at the counter electrode end to obtain the drug delivery module;

[0046] Wherein, the micro-needle structure with mesopores and the flexible gold electrode are on both sides of the hydrogel substrate.

[0047] On the other hand, an embodiment of the present application provides an electronic device, the electronic device includes a memory and a processor, the memory stores a computer program, and when the processor executes the computer program, the above-mentioned blood pressure monitoring and control method based on the ionophoresis effect of microporous electrodes is realized.

[0048] On the other hand, an embodiment of the present application provides a computer-readable storage medium, the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the above-mentioned blood pressure monitoring and control method based on the ionophoresis effect of microporous electrodes is realized.

[0049] In the embodiment of the present application, by collecting the pulse wave signal and the electrocardiogram signal in real time and calculating the blood pressure index in real time, the dynamic monitoring of the user's blood pressure index can be realized, and when the blood pressure index is abnormal, according to the drug delivery control instruction sent by the mobile terminal, through the ionophoresis effect of the microporous electrode, the drug delivery module automatically administers medicine for treatment, which helps to safely and accurately regulate the user's blood pressure and improve the user experience. Description of the Drawings

[0050] Figure 1 is a schematic structural diagram of a blood pressure monitoring and control device based on the ionophoresis effect of microporous electrodes provided by an embodiment of the present application;

[0051] Figure 2 is a schematic diagram of the implementation environment of a blood pressure monitoring and control method based on the ionophoresis effect of microporous electrodes provided by an embodiment of the present application;

[0052] Figure 3It is a schematic flowchart of a blood pressure monitoring and control method based on the ionophoretic effect of a microelectrode provided by an embodiment of the present application;

[0053] Figure 4 It is a schematic process diagram of preparing a pulse acquisition module provided by an embodiment of the present application;

[0054] Figure 5 It is a schematic process diagram of preparing an electrocardiogram acquisition module provided by an embodiment of the present application;

[0055] Figure 6 It is a schematic process diagram of preparing a micro-needle structure at the working electrode end provided by an embodiment of the present application;

[0056] Figure 7 It is a schematic structural diagram of an electronic device provided by an embodiment of the present application. Detailed implementation manners

[0057] In order to make the objectives, technical solutions and advantages of the present application clearer and more understandable, the present application will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application. When the following description involves the accompanying drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The implementation manners described in the following exemplary embodiments do not represent all the implementation manners consistent with the embodiments of the present application. They are only examples of devices and methods consistent with some aspects of the embodiments of the present application detailed in the appended claims.

[0058] It can be understood that the terms "first", "second", etc. used in the present application can be used herein to describe various concepts, but unless otherwise specified, these concepts are not limited by these terms. These terms are only used to distinguish one concept from another. For example, without departing from the scope of the embodiments of the present application, the first information can also be referred to as the second information, and similarly, the second information can also be referred to as the first information. Depending on the context, the words "if", "when" used herein can be interpreted as "when...", "when...", or "in response to determining".

[0059] The terms "at least one", "a plurality of", "each", "any one", etc. used in the present application, at least one includes one, two or more than two, a plurality of includes two or more than two, each refers to each of the corresponding plurality, and any one refers to any one of the plurality.

[0060] Unless otherwise defined, all the technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field to which the present application belongs. The terms used herein are only for the purpose of describing the embodiments of the present application and are not intended to limit the present application.

[0061] Currently, due to the changes in people's lifestyles, cardiovascular diseases have become highly prevalent in modern society. Hypertension is the primary risk factor for cardiovascular and cerebrovascular diseases, characterized by being difficult to control, having a high incidence of cardiovascular, cerebrovascular, and renal complications, and a high mortality rate. The level of blood pressure affects the blood supply to all tissues and organs throughout the body (including vital organs such as the heart, brain, and kidneys). Excessive pressure can cause arteriosclerosis, reducing the blood and oxygen flowing to the heart. In addition, hypertension can also lead to kidney damage and renal failure. Therefore, scientific and effective blood pressure management is of great guiding significance for the prevention and treatment of cardiovascular diseases. In patients with hypertensive emergencies, due to internal or environmental inducing factors, blood pressure rises sharply within a short period, easily causing serious consequences such as aortic dissection and cerebral hemorrhage, threatening life safety. Due to the sudden onset of acute hypertension, clinical intervention and control are more complex and difficult.

[0062] In related technologies, conventional clinic blood pressure and ambulatory blood pressure measurements are achieved by cuff pressurization. The methods for treating hypertension usually include oral administration and sublingual administration. However, in practical applications, it has been found that the method of blood pressure measurement achieved by cuff pressurization cannot monitor blood pressure frequently over a long period, making it difficult to meet the needs of hypertension diagnosis and early warning. Casual blood pressure measurement only provides the instantaneous blood pressure at a certain moment, which is difficult to objectively reflect the patient's all-day blood pressure level, let alone the blood pressure fluctuations caused by different environmental conditions or physiological and pathological changes in the patient.

[0063] On the other hand, the methods for treating hypertension include oral administration, sublingual administration, intravenous injection of antihypertensive drugs, etc. Among them, oral administration is convenient and does not damage the skin and mucous membranes, but its absorption is slow and irregular. Sublingual administration enters the blood through the sublingual capillaries, with complete and relatively fast absorption, but the dosage of sublingual administration is limited. Intravenous injection has fast absorption and can reach a relatively high dosage, but it requires the presence of professional medical staff and is prone to inconvenience and skin trauma. The treatment of hypertension is a long-term process, and the treatment of acute hypertension and hypertension with multiple complications requires a higher frequency of medication. Therefore, the existing treatment methods lack a more automated drug delivery method that requires little manual intervention.

[0064] In view of this, in the embodiments of the present application, a blood pressure monitoring and control device and method based on the iontophoresis effect of microporous electrodes are provided. By real-time collecting pulse wave signals and electrocardiogram signals and calculating blood pressure indicators in real time, it can achieve dynamic monitoring of the user's blood pressure indicators. When the blood pressure indicators are abnormal, according to the drug delivery control instructions sent by the mobile terminal, through the iontophoresis effect of microporous electrodes, the drug delivery module automatically performs drug treatment, which helps to safely and accurately regulate the user's blood pressure and improve the user experience.

[0065] It should be noted that in each specific embodiment of the present application, when it comes to relevant processing based on data related to the user's identity or characteristics, such as user information, user behavior data, user historical data, and user location information, the user's permission or consent will be obtained first. Moreover, the collection, use, and processing of these data will comply with relevant laws, regulations, and standards. In addition, when the embodiments of the present application need to obtain the user's sensitive personal information, the user's separate permission or separate consent will be obtained through methods such as pop-up windows or redirecting to a confirmation page. After clearly obtaining the user's separate permission or separate consent, the necessary user-related data for the normal operation of the embodiments of the present application will be obtained.

[0066] Next, with reference to the accompanying drawings, the specific embodiments of the embodiments of the present application will be described in detail. First, a blood pressure monitoring and control device based on the ionophoretic effect of microelectrodes will be described in combination with the accompanying drawings.

[0067] Please refer to Figure 1 , Figure 1 FIG. is a schematic structural diagram of a blood pressure monitoring and control device based on the ionophoretic effect of microelectrodes provided by an embodiment of the present application. The device includes: a signal acquisition module, a signal modulation module, a single-chip microcomputer system module, a signal transmission module, and a drug delivery module;

[0068] The signal acquisition module is used to acquire signals. The signal acquisition module includes a pulse acquisition module for acquiring pulse wave signals and an electrocardiogram acquisition module for acquiring electrocardiogram signals;

[0069] The signal modulation module is wirelessly communicatively connected to the signal acquisition module and is used to perform signal processing on the acquired signals;

[0070] The single-chip microcomputer system module is used to receive the processed pulse wave signals and electrocardiogram signals; it is also used to calculate blood pressure indicators based on the processed pulse wave signals and electrocardiogram signals;

[0071] The signal transmission module is used to transmit the processed pulse wave signals, electrocardiogram signals, and blood pressure indicator calculation results to a mobile terminal; it is also used to receive drug delivery control instructions issued by the mobile terminal;

[0072] The drug delivery module is used to deliver blood pressure treatment drugs through the ionophoretic effect of microelectrodes.

[0073] In the embodiments of the present application, the blood pressure monitoring and control device based on the ionophoretic effect of microelectrodes mainly includes: a signal acquisition module, a signal modulation module, a single-chip microcomputer system module, a signal transmission module, and a drug delivery module.

[0074] Among them, the signal acquisition module is mainly used to acquire human biological signals. For example, the pulse wave signal is acquired through the pulse acquisition module, and the electrocardiogram signal is acquired through the electrocardiogram acquisition module.

[0075] Furthermore, the signal acquisition module is wirelessly connected to the signal modulation module. The signal modulation module can receive the pulse wave signal and the electrocardiogram signal transmitted by the signal acquisition module, and further perform signal modulation processing on the pulse wave signal and the electrocardiogram signal. For example, signal filtering, signal amplification, and analog-to-digital signal conversion can be performed on the pulse wave signal and the electrocardiogram signal, etc.

[0076] The single-chip microcomputer system module is used to receive the pulse wave signal and the electrocardiogram signal after signal processing, and according to the pre-constructed pulse transit time - pulse wave velocity (PTT - PWV) algorithm model, couple the pulse acquisition module and the electrocardiogram acquisition module to establish the correlation relationship between the pulse wave - electrocardiogram - blood pressure signals, and calculate the blood pressure index using the processed pulse wave signal and electrocardiogram signal.

[0077] Exemplarily, the pulse transit time (PTT) of the acquired pulse wave can be calculated according to the time difference between the R wave of the electrocardiogram signal and the characteristic peak of the pulse wave. Then, according to the vascular hemodynamics Moens - Koreteweg model and the Hughes equation, the pulse wave velocity (PWV) can be calculated. By using the standard blood pressure value measured by the blood pressure reference value as the calibration value, the blood pressure index calculation result (including systolic blood pressure SBP and diastolic blood pressure DBP) can be calculated.

[0078] Furthermore, the signal transmission module can transmit the processed pulse wave signal, electrocardiogram signal, and blood pressure index calculation result to the mobile terminal. In some embodiments, the terminal can be a smart phone, a tablet computer, a laptop computer, a desktop computer, a smart speaker, a smart watch, and a vehicle-mounted terminal, etc., but is not limited thereto.

[0079] In practical applications, after the mobile terminal receives the pulse wave signal, electrocardiogram signal, and blood pressure index calculation result, it can further perform processing, judgment, and feedback, and can also store records to facilitate the user to query the historical results of blood pressure monitoring at any time.

[0080] Optionally, the mobile terminal can determine whether the blood pressure index is abnormal according to the blood pressure index calculation result, and then issue different drug delivery control instructions. For example, when the blood pressure index is abnormal and it is judged that the user may have hypertension, the drug delivery control instruction to start drug delivery can be issued.

[0081] In practical applications, when the signal transmission module receives the drug delivery control instruction sent by the mobile terminal, it can forward it to the single-chip microcomputer system module, and the single-chip microcomputer system module can control the drug delivery module for delivering blood pressure treatment drugs according to the drug delivery control instruction. For example, when the single-chip microcomputer system module recognizes the drug delivery control instruction to start delivering drugs, it can turn on the circuit of the drug delivery module, so that the drug delivery module starts to deliver blood pressure treatment drugs to facilitate the control of the user's blood pressure index.

[0082] In practical applications, a constant current source control module can also be integrated inside the blood pressure monitoring and control device based on the iontophoresis effect of microelectrodes. The opening and closing of the drug delivery module are controlled by the constant current source control module, and the constant current source control module can be connected to the single-chip microcomputer system module and controlled by the single-chip microcomputer system module.

[0083] In the embodiment of the present application, the drug delivery module mainly includes a working electrode end micro-needle structure and a counter electrode end micro-needle structure. The counter electrode end can close the circuit and complete the electrochemical reaction by cooperating with the working electrode. In the drug delivery module, the working electrode end micro-needle structure includes a hydrogel substrate containing blood pressure treatment drugs. The micro-needle microelectrode first penetrates the surface layer of the skin (such as the stratum corneum) by applying pressure or other mechanical means, but does not enter the deep layer of the skin. The micro-needle structure can help create micropores, which enable drugs to more easily penetrate the barrier layer of the skin. When an electric field is applied, drug molecules (usually charged molecules) move deeper into the skin along the direction of the current under the drive of the electric field. Through the channels created by the micro-needle microelectrodes, drugs can efficiently enter the deeper layer of the skin (such as the dermis layer) through the stratum corneum and finally enter the circulatory system or the target tissue, thereby realizing the delivery of blood pressure treatment drugs by using the iontophoresis effect of microelectrodes; while the counter electrode, as the other end of the electrochemical circuit, is mainly used to balance the charge flow but does not participate in drug delivery.

[0084] Specifically, as an optional implementation manner, the pulse acquisition module includes: a polyester substrate and a micro-nano needle structure;

[0085] A metal conductive layer is deposited on the polyester substrate;

[0086] The micro-nano needle structure includes a first micro-needle structure prepared from a polydimethylsiloxane substrate, a zinc oxide layer nano-needle structure is grown on the surface of the first micro-needle structure, and a metal conductive layer is deposited on the surface of the zinc oxide layer nano-needle structure.

[0087] In the embodiment of the present application, the pulse acquisition module for collecting pulse wave signals can be obtained by encapsulating a polyester substrate and a micro-nano needle structure, and specifically can be a flexible mechanical sensor with a composite micro-nano needle sandwich structure.

[0088] Among them, the polyester substrate is a PET film, and a metal conductive layer is deposited on the surface of the PET film. For example, (gold Au) can be used as the conductive metal. The micro-nano needle structure can be prepared by adopting micro-nano processing techniques (such as photolithography and centrifugal casting) on a flexible polydimethylsiloxane (PDMS) substrate to obtain a basic first micro-needle structure, and then a layer of zinc oxide nano-needle structure is formed on the surface of the first micro-needle structure by hydrothermal growth method, and then a metal conductive layer (such as gold) is deposited on the surface of the zinc oxide nano-needle structure by magnetron sputtering method, so as to obtain a secondary ZnO / Au nano-needle structure, forming a composite micro-nano needle structure. Then, by superimposing and encapsulating the prepared PET film and the composite micro-nano needle structure, a pulse acquisition module can be obtained.

[0089] The pulse acquisition module prepared through the above embodiments has good electrical conductivity and chemical stability, and can better capture and record the pulse wave signal of the user's body.

[0090] Specifically, as an optional implementation manner, the electrocardiogram acquisition module is obtained by encapsulating and integrating at least one second micro-needle structure;

[0091] The second micro-needle structure is prepared from a polydimethylsiloxane substrate; a metal conductive layer is deposited on the surface of the second micro-needle structure.

[0092] In the embodiments of the present application, the electrocardiogram acquisition module for acquiring electrocardiogram signals can be obtained by encapsulating and integrating at least one second micro-needle structure.

[0093] Among them, the second micro-needle structure can be prepared by adopting micro-nano processing techniques (such as photolithography and centrifugal casting) on a flexible polydimethylsiloxane (PDMS) substrate to obtain a basic second micro-needle structure, and then a metal conductive layer (such as gold) is deposited on the surface of the zinc oxide nano-needle structure by magnetron sputtering method, so as to obtain the second micro-needle structure.

[0094] Furthermore, the area outside the tip of the micro-needle structure, such as the substrate, can be further insulated, so that the second micro-needle structure forms a micro-needle electrode, and at least one second micro-needle structure is encapsulated and integrated to obtain an electrocardiogram acquisition module.

[0095] Exemplarily, three second microneedle structure encapsulation sets forming microneedle electrodes can be integrated into an electrocardiogram acquisition module. Among them, the first electrode is placed on the left arm, mainly used to record the potential changes of cardiac electrical activities. The second electrode is placed on the right arm, used to form a lead combination. The third electrode is placed on the left leg. Thus, an acquisition method of three-lead bipolar detection is formed through the first electrode, the second electrode, and the third electrode. Among them, the first lead combination is left arm - right arm, and the detection direction is the horizontal direction, mainly recording the left - right potential difference of cardiac electrical activities; the second lead combination is left leg - right arm, and the detection direction is from the upper right to the lower left, reflecting the dominant electrical activity direction; the third lead combination is left leg - left arm, mainly recording the vertical changes of cardiac electrical activities. Through the above three lead combinations, the human electrocardiogram signals of the user can be effectively acquired.

[0096] Of course, it can be understood that the above-described implementation manner of encapsulating and integrating microneedle electrodes to obtain an electrocardiogram acquisition module is only some optional implementation manners of the electrocardiogram acquisition module provided in this application. The actual application is not fixed to the above implementation manner, and this application does not make specific limitations on this.

[0097] Specifically, as an optional implementation manner, the drug delivery module includes a working electrode end microneedle structure and a counter electrode end microneedle structure;

[0098] The working electrode end microneedle structure includes a hydrogel substrate containing a blood pressure treatment drug. A flexible gold electrode is embedded on one side of the hydrogel substrate, and a microneedle structure with mesopores is formed on the other side of the hydrogel substrate;

[0099] The counter electrode end microneedle structure includes a hydrogel substrate. A flexible gold electrode is embedded on one side of the hydrogel substrate, and a microneedle structure with mesopores is formed on the other side of the hydrogel substrate.

[0100] In the embodiments of this application, the drug delivery module mainly includes a working electrode end microneedle structure and a counter electrode end microneedle structure. The counter electrode end can close the circuit and complete the electrochemical reaction by cooperating with the working electrode. In the drug delivery module, the working electrode end microneedle structure includes a hydrogel substrate containing a blood pressure treatment drug. The microporous microneedle electrode first penetrates the surface layer of the skin (such as the stratum corneum) by applying pressure or other mechanical means, but does not enter the deep layer of the skin. The microneedle structure can help create micropores, and these micropores enable the drug to more easily penetrate the barrier layer of the skin. When an electric field is applied, drug molecules (usually charged molecules) move deeper into the skin along the direction of the current under the drive of the electric field. Through the channels created by the microporous microneedles, the drug can efficiently enter the deeper layer of the skin (such as the dermis layer) through the stratum corneum and finally enter the circulatory system or the target tissue, thus realizing the delivery of the blood pressure treatment drug by using the iontophoresis effect of the microporous electrode; while the counter electrode, as the other end of the electrochemical circuit, is mainly used to balance the charge flow but does not participate in drug delivery.

[0101] Among them, on one side of the hydrogel substrate of the working electrode end micro-needle structure, a flexible gold electrode is embedded, and on the other side, a micro-needle structure with mesopores is formed. The mesopores can increase the specific surface area, which is beneficial to the storage and delivery of drugs and improve the penetration performance of the tip of the micro-needle structure, and helps to enhance the interaction with biological tissues. The hydrogel substrate of the counter electrode end micro-needle structure does not contain blood pressure treatment drugs.

[0102] That is to say, the blood pressure monitoring and control device based on the iontophoresis effect of micro-hole electrodes provided by this application can be applied to non-invasive continuous monitoring of weak signals (such as pulse wave signals), and can also use the pulse transit time - pulse wave velocity (PTT-PWV) algorithm model to establish the correlation between pulse - electrocardiogram - blood pressure signals. In addition, through the developed iontophoresis-assisted transdermal controlled drug delivery technology using micro-hole electrodes, it can safely and accurately regulate the user's blood pressure index, and can adjust the diffusion efficiency and rate of drugs entering capillaries by adjusting the magnitude of the electric field strength, etc., providing a hypertension monitoring and control treatment plan.

[0103] Please refer to Figure 2 , Figure 2 which is a schematic diagram of the implementation environment of a blood pressure monitoring and control method based on the iontophoresis effect of micro-hole electrodes provided by an embodiment of this application. In this implementation environment, the main software and hardware entities involved include a blood pressure monitoring and control device based on the iontophoresis effect of micro-hole electrodes and a server.

[0104] Specifically, the blood pressure monitoring and control device based on the iontophoresis effect of micro-hole electrodes is communicatively connected to the server. The blood pressure monitoring and control method based on the iontophoresis effect of micro-hole electrodes provided in the embodiments of this application can be executed on the side of the blood pressure monitoring and control device based on the iontophoresis effect of micro-hole electrodes.

[0105] The server can be an independent physical server, or a server cluster or distributed system composed of multiple physical servers, or a cloud server that provides basic cloud computing services such as cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communications, middleware services, domain name services, security services, CDN (Content Delivery Network), and big data and artificial intelligence platforms. In addition, the server can also be a node server in a blockchain network.

[0106] A communication connection can be established between the blood pressure monitoring and control device based on the ionophoretic effect of microelectrodes and the server through a wireless network. The wireless network uses standard communication technologies and / or protocols. The network can be set as the Internet or any other network, such as including but not limited to any combination of a Local Area Network (LAN), a Metropolitan Area Network (MAN), a Wide Area Network (WAN), a mobile or wireless network, a private network, or a virtual private network. Moreover, between these software and hardware entities, the same communication connection method or different communication connection methods can be adopted, and the present application does not make specific restrictions on this.

[0107] Of course, it can be understood that Figure 2 the implementation environments in Figure 2 are only some optional application scenarios in the blood pressure monitoring and control method based on the ionophoretic effect of microelectrodes provided in the embodiments of the present application. The actual application is not fixedly the

[0108] As Figure 3 shown, Figure 3 is a schematic flowchart of a blood pressure monitoring and control method based on the ionophoretic effect of microelectrodes provided in the embodiments of the present application. The blood pressure monitoring and control method based on the ionophoretic effect of microelectrodes specifically includes but is not limited to:

[0109] Collecting a pulse wave signal and an electrocardiogram signal;

[0110] Performing signal processing on the pulse wave signal and the electrocardiogram signal, so as to calculate blood pressure indicators according to the pulse wave signal and the electrocardiogram signal after signal processing;

[0111] Transmitting the pulse wave signal and the electrocardiogram signal after signal processing and the blood pressure indicator calculation result to a mobile terminal, and receiving a drug delivery control instruction issued by the mobile terminal;

[0112] Determining the opening and closing state of the drug delivery module according to the drug delivery control instruction;

[0113] Among them, the pulse wave signal is collected by a pulse collection module, and the electrocardiogram signal is collected by an electrocardiogram collection module; when the drug delivery module is in an open state, a blood pressure treatment drug is delivered through the ionophoretic effect of microelectrodes.

[0114] In the embodiments of the present application, the pulse wave signal and the electrocardiogram signal can be collected, and signal processing such as signal filtering, signal amplification, and digital-to-analog conversion can be performed on the pulse wave signal and the electrocardiogram signal. The blood pressure index of the user can be calculated according to the pulse wave signal and the electrocardiogram signal after signal processing. For example, the systolic blood pressure and diastolic blood pressure of the user can be calculated by using the pulse transit time - pulse wave velocity (PTT-PWV) algorithm model.

[0115] Further, the pulse wave signal and the electrocardiogram signal after signal processing and the calculation result of the blood pressure index are transmitted to the mobile terminal. The microprocessor of the mobile terminal processes, judges, gives feedback, and records, and receives the drug delivery control instruction issued by the mobile terminal, and controls the opening and closing state of the drug delivery module according to the drug delivery control instruction. Among them, the drug delivery module can utilize the iontophoresis effect of the microporous electrode to achieve drug delivery.

[0116] Specifically, as an alternative embodiment, please refer to Figure 4 , Figure 4 FIG. is a process schematic diagram of preparing a pulse acquisition module provided by the embodiments of the present application. The pulse acquisition module is prepared through the following steps:

[0117] The first micro-needle structure is prepared on a flexible polydimethylsiloxane substrate through photolithography and centrifugal casting;

[0118] A zinc oxide layer nanoneedle structure is grown on the surface of the first micro-needle structure by a hydrothermal growth method;

[0119] A metal conductive layer is deposited on the surface of the zinc oxide layer nanoneedle structure by magnetron sputtering to obtain a micro-nano needle structure;

[0120] A metal conductive layer is deposited on a polyester substrate by magnetron sputtering to obtain a prepared polyester substrate;

[0121] The micro-nano needle structure and the prepared polyester substrate are encapsulated to obtain the pulse acquisition module.

[0122] In the embodiments of the present application, first, the shape of the first micro-needle structure is engraved on the SU8 photoresist by photolithography, and then a flexible polydimethylsiloxane is used as a substrate to prepare a basic first micro-needle structure by centrifugal casting. Then, a zinc oxide layer nanoneedle structure is grown on the surface of the first micro-needle structure by a hydrothermal growth method. Then, a metal conductive layer is deposited on the surface of the nanoneedle structure by magnetron sputtering, and thus a composite micro-nano needle structure is obtained.

[0123] Further, a metal conductive layer is deposited on the surface of a polyester substrate (PET film) by magnetron sputtering to obtain a prepared polyester substrate.

[0124] Finally, the prepared polyester substrate is encapsulated with the composite micro-nano needle structure to obtain a pulse acquisition module with a composite micro-nano needle sandwich structure.

[0125] In practical applications, after the preparation of the pulse acquisition module, a scanning electron microscope can also be used to characterize the prepared composite micro-nano needle structure, and further evaluate the electrical performance, mechanical response performance, reliability under repeated stress, and flexibility performance of the pulse acquisition module. Explore the mechanism of the mechanical response of flexible mechanical devices, and evaluate the recording performance and accuracy of the mechanical sensor for epidermal pulse signals at the radial artery of the human body in a static and moderately moving state.

[0126] Optionally, by optimizing the micro-needle structure into a nano-needle structure, the contact area when contacting an external object can be significantly increased, thereby enhancing the triboelectric effect and sensitivity, and improving the working performance of the pulse acquisition module.

[0127] Specifically, as an optional implementation manner, please refer to Figure 5 , Figure 5 which is a process schematic diagram of a method for preparing an electrocardiogram acquisition module provided by an embodiment of the present application. The electrocardiogram acquisition module is prepared through the following steps:

[0128] A second micro-needle structure is prepared on a flexible polydimethylsiloxane substrate through photolithography and centrifugal casting;

[0129] A metal conductive layer is deposited on the surface of the second micro-needle structure through magnetron sputtering;

[0130] The substrate of the second micro-needle structure is insulated to obtain a micro-needle electrode;

[0131] At least one of the micro-needle electrodes is encapsulated and integrated to obtain an electrocardiogram acquisition module.

[0132] In the embodiment of the present application, first, the shape of the second micro-needle structure is etched on the SU8 photoresist through photolithography, and then a flexible polydimethylsiloxane is used as the substrate to prepare a basic second micro-needle structure through centrifugal casting. Then, a metal conductive layer is deposited on the surface of the basic second micro-needle structure through magnetron sputtering. Furthermore, the substrate of the second micro-needle structure is insulated to obtain a micro-needle electrode. Finally, at least one micro-needle electrode (exemplarily, Figure 5 there are three micro-needle electrodes in

[0133] In practical applications, after the preparation of the electrocardiogram acquisition module, a scanning electron microscope can also be used to characterize the prepared micro-needle electrode, and evaluate the electrical performance, reliability under repeated stress, and flexibility performance of the electrocardiogram acquisition module.

[0134] Optionally, asFigure 5 As shown, when three micro-needle electrodes are encapsulated and integrated into an electrocardiogram acquisition module, a three-lead bipolar detection method can be adopted, and the three electrodes can be respectively placed on the user's left arm, right arm and left leg (or chest).

[0135] Specifically, as an optional implementation manner, the drug delivery module is prepared through the following steps:

[0136] Prepare a micro-needle structure mold through photolithography and centrifugal casting;

[0137] Prepare a micro-needle structure through polyethylene glycol diacrylate and the micro-needle structure mold, incorporate zinc oxide nanowires at the tip of the micro-needle structure, and immerse the tip of the micro-needle structure in an acidic solution to dissolve the zinc oxide nanowires to form mesopores, obtaining a micro-needle structure with mesopores;

[0138] Prepare a hydrogel substrate through polyethylene glycol diacrylate, and load a blood pressure treatment drug inside the hydrogel substrate;

[0139] Embed a flexible gold electrode in the hydrogel substrate and perform a demolding process to obtain a micro-needle structure at the working electrode end;

[0140] Prepare a micro-needle structure mold through photolithography and centrifugal casting;

[0141] Prepare a micro-needle structure through polyethylene glycol diacrylate and the micro-needle structure mold, incorporate zinc oxide nanowires at the tip of the micro-needle structure, and immerse the tip of the micro-needle structure in an acidic solution to dissolve the zinc oxide nanowires to form mesopores, obtaining a micro-needle structure with mesopores;

[0142] Prepare a hydrogel substrate through polyethylene glycol diacrylate, embed a flexible gold electrode in the hydrogel substrate, and perform a demolding process to obtain a micro-needle structure at the counter electrode end;

[0143] Package the micro-needle structure at the working electrode end and the micro-needle structure at the counter electrode end to obtain the drug delivery module;

[0144] Wherein, the micro-needle structure with mesopores and the flexible gold electrode are on both sides of the hydrogel substrate.

[0145] In the embodiments of the present application, the drug delivery module is mainly obtained by integrating and packaging the micro-needles at the working electrode end and the micro-needles at the counter electrode end into an integrated device.

[0146] Specifically, please refer to Figure 6 , Figure 6It is a process schematic diagram for preparing a micro-needle structure at the working electrode end provided by an embodiment of the present application. When preparing the micro-needle structure at the working electrode end, first, a micro-needle structure mold is prepared through micro-nano lithography technology and multi-step centrifugation method. Then, a micro-needle structure is prepared using polyethylene glycol diacrylate (PEGDA) and the micro-needle structure mold. The polyethylene glycol diacrylate is photocrosslinked and cured to form a hard tip part. And during the preparation of the tip of the micro-needle structure, zinc oxide (ZnO) nanowires are incorporated, and the tip of the micro-needle structure is immersed in an acidic solution to dissolve the zinc oxide nanowires, forming a mesoporous structure. Thus, a micro-needle structure with mesopores is obtained, which can be used to penetrate the skin surface and enhance the drug delivery effect.

[0147] Further, by adjusting the intensity and time of photocrosslinking to reduce the degree of crosslinking, a hydrogel substrate is prepared using polyethylene glycol diacrylate, and a blood pressure treatment drug is loaded in the hydrogel substrate. Among them, the blood pressure treatment drug can be the clinical antihypertensive drug sodium nitroprusside. The present application does not make specific restrictions on this, and it can be selected according to specific usage scenarios and clinical treatments.

[0148] Finally, one side of the hydrogel substrate is cured with the micro-needle structure having mesopores. Then, a flexible gold electrode is embedded on the other side of the hydrogel substrate, and the flexible gold electrode is encapsulated and demolded to obtain the micro-needle structure at the working electrode end.

[0149] Exemplarily, referring to the preparation process of the micro-needle structure at the working electrode end, since the micro-needle structure at the counter electrode end does not need to participate in drug delivery, when preparing the micro-needle structure at the counter electrode end, it is not necessary to load a blood pressure treatment drug in the hydrogel substrate. Specifically, a micro-needle structure mold is prepared through photolithography and centrifugal casting; a micro-needle structure is prepared using polyethylene glycol diacrylate and the micro-needle structure mold, and zinc oxide nanowires are incorporated at the tip of the micro-needle structure, and the tip of the micro-needle structure is immersed in an acidic solution to dissolve the zinc oxide nanowires, forming mesopores, and a micro-needle structure with mesopores is obtained; a hydrogel substrate is prepared using polyethylene glycol diacrylate, a flexible gold electrode is embedded in the hydrogel substrate, and demolding treatment is carried out to obtain the micro-needle structure at the counter electrode end.

[0150] Finally, the micro-needle structure at the working electrode end and the micro-needle structure at the counter electrode end are encapsulated to obtain a drug delivery module.

[0151] Optionally, a scanning electron microscope can also be used to characterize the micro-needle structure at the working electrode end and the micro-needle structure at the counter electrode end, and evaluate the transdermal effect, mechanical properties, and post-transdermal biosafety of the drug delivery module based on the iontophoresis effect of the microporous electrode.

[0152] It can be understood that the content in the above method embodiments is applicable to the above device embodiments. The functions specifically implemented by the above device embodiments are the same as those of the above method embodiments, and the beneficial effects achieved are also the same as those of the above method embodiments.

[0153] Next, in combination with the specific application implementation process, the blood pressure monitoring and control device provided in this application based on the ionophoretic effect of microelectrodes will be introduced and described in detail:

[0154] In an embodiment of this application, a blood pressure monitoring and control device based on the ionophoretic effect of microelectrodes is provided, which can be applied to the blood pressure monitoring and control scenario. By collecting the pulse wave signal and electrocardiogram signal in real time and calculating the blood pressure index in real time, it can realize the dynamic monitoring of the user's blood pressure index. And when the blood pressure index is abnormal, according to the drug delivery control instruction sent by the mobile terminal, through the ionophoretic effect of the microelectrode, the drug delivery module automatically performs drug treatment, which helps to safely and accurately regulate the user's blood pressure and improve the user experience.

[0155] First of all, the blood pressure monitoring and control device based on the ionophoretic effect of microelectrodes mainly includes: a signal acquisition module, a signal modulation module, a single-chip microcomputer system module, a signal transmission module, and a drug delivery module.

[0156] Among them, the signal acquisition module is mainly used to collect human biological signals. For example, the pulse wave signal is collected through the pulse acquisition module, and the electrocardiogram signal is collected through the electrocardiogram acquisition module.

[0157] Furthermore, the signal acquisition module is wirelessly connected to the signal modulation module. The signal modulation module can receive the pulse wave signal and electrocardiogram signal transmitted by the signal acquisition module, and further perform signal modulation processing on the pulse wave signal and electrocardiogram signal. For example, signal filtering, signal amplification, and analog-to-digital signal conversion can be performed on the pulse wave signal and electrocardiogram signal, etc.

[0158] The single-chip microcomputer system module is used to receive the pulse wave signal and electrocardiogram signal after signal processing, and according to the pre-constructed pulse transit time - pulse wave velocity (PTT - PWV) algorithm model, couple the pulse acquisition module and the electrocardiogram acquisition module to establish the correlation between the pulse wave - electrocardiogram - blood pressure signals, and calculate the blood pressure index using the processed pulse wave signal and electrocardiogram signal.

[0159] Exemplarily, the collected pulse transit time (PTT) can be calculated based on the time difference between the R wave of the electrocardiogram signal and the characteristic peak of the pulse wave. Furthermore, according to the vascular hemodynamics Moens-Koreteweg model and the Hughes equation, the pulse wave velocity (PWV) can be calculated. Then, by using the standard blood pressure value measured with the blood pressure reference value as the calibration value, the calculation result of the blood pressure index (including systolic blood pressure SBP and diastolic blood pressure DBP) can be calculated.

[0160] Further, the signal transmission module can transmit the processed pulse wave signal, electrocardiogram signal, and the calculation result of the blood pressure index to the mobile terminal. In some embodiments, the terminal can be a smart phone, a tablet computer, a laptop computer, a desktop computer, a smart speaker, a smart watch, a vehicle terminal, etc., but is not limited thereto.

[0161] In practical applications, after receiving the pulse wave signal, electrocardiogram signal, and the calculation result of the blood pressure index, the mobile terminal can further perform processing, judgment, and feedback, and can also store records for the user to query the historical results of blood pressure monitoring at any time.

[0162] Optionally, the mobile terminal can determine whether the blood pressure index is abnormal based on the calculation result of the blood pressure index, and then issue different drug delivery control instructions. For example, when the blood pressure index is abnormal and it is judged that the user may have hypertension, the drug delivery control instruction to start drug delivery can be issued.

[0163] In practical applications, when the signal transmission module receives the drug delivery control instruction issued by the mobile terminal, it can forward it to the single-chip microcomputer system module, and the single-chip microcomputer system module can control the drug delivery module for delivering blood pressure treatment drugs according to the drug delivery control instruction. For example, when the single-chip microcomputer system module recognizes the drug delivery control instruction to start drug delivery, it can turn on the circuit of the drug delivery module, so that the drug delivery module starts to deliver blood pressure treatment drugs to control the user's blood pressure index.

[0164] Optionally, a constant current source control module can be integrated inside the blood pressure monitoring and control device based on the iontophoresis effect of microelectrodes. The opening and closing of the drug delivery module are controlled by the constant current source control module, and the constant current source control module can be connected to the single-chip microcomputer system module and controlled by the single-chip microcomputer system module.

[0165] In practical applications, the drug delivery module mainly includes a working electrode end microneedle structure and a counter electrode end microneedle structure. The counter electrode end can cooperate with the working electrode to close the circuit and complete the electrochemical reaction. In the drug delivery module, the working electrode end microneedle structure includes a hydrogel substrate containing a blood pressure treatment drug. The microporous microneedle electrode first penetrates the surface layer of the skin (such as the stratum corneum) by applying pressure or other mechanical means, but does not enter the deep layer of the skin. The microneedle structure can help create micropores, which enable the drug to more easily penetrate the barrier layer of the skin. When an electric field is applied, drug molecules (usually charged molecules) move deeper into the skin along the direction of the current under the drive of the electric field. Through the channels created by the microporous microneedles, the drug can efficiently enter the deeper layer of the skin (such as the dermis layer) through the stratum corneum and finally enter the circulatory system or the target tissue, thus realizing the delivery of blood pressure treatment drugs by utilizing the iontophoresis effect of the microporous electrode; while the counter electrode, as the other end of the electrochemical circuit, is mainly used to balance the charge flow but does not participate in drug delivery.

[0166] Furthermore, the pulse acquisition module for collecting pulse wave signals can be obtained by encapsulating and processing a polyester substrate and a micro-nano needle structure, specifically a flexible mechanical sensor with a composite micro-nano needle sandwich structure.

[0167] Among them, the polyester substrate is a PET film, and a metal conductive layer is deposited on the surface of the PET film. For example, (gold Au) can be used as the conductive metal. The micro-nano needle structure can be prepared by using micro-nano processing techniques (such as photolithography and centrifugal casting) on a flexible polydimethylsiloxane (PDMS) substrate to obtain a basic first micro-nano needle structure, and then a layer of zinc oxide nano-needle structure is formed on the surface of the first micro-nano needle structure by hydrothermal growth method, and then a metal conductive layer (such as gold) is deposited on the surface of the zinc oxide nano-needle structure by magnetron sputtering method to obtain a secondary ZnO / Au nano-needle structure, forming a composite micro-nano needle structure. Then, by superimposing and encapsulating the prepared PET film and the composite micro-nano needle structure, the pulse acquisition module can be obtained.

[0168] Furthermore, the electrocardiogram acquisition module for collecting electrocardiogram signals can be obtained by encapsulating and integrating at least one second micro-nano needle structure.

[0169] Among them, the second micro-nano needle structure can be prepared by using micro-nano processing techniques (such as photolithography and centrifugal casting) on a flexible polydimethylsiloxane (PDMS) substrate to obtain a basic second micro-nano needle structure, and then a metal conductive layer (such as gold) is deposited on the surface of the zinc oxide nano-needle structure by magnetron sputtering method to obtain the second micro-nano needle structure.

[0170] Finally, the drug delivery module mainly includes a working electrode end microneedle structure and a counter electrode end microneedle structure. The counter electrode end can cooperate with the working electrode to close the circuit and complete the electrochemical reaction.

[0171] Please refer to Figure 7 , Figure 7 which is a schematic structural diagram of an electronic device provided by an embodiment of the present application. The electronic device includes:

[0172] A processor 701, which can be implemented in ways such as a general-purpose CPU (Central Processing Unit), a microprocessor, an application-specific integrated circuit (ASIC), or one or more integrated circuits, and is used to execute relevant programs to implement the technical solutions provided by the embodiments of the present application;

[0173] A memory 702, which can be implemented in forms such as a read-only memory (ROM), a static storage device, a dynamic storage device, or a random access memory (RAM). The memory 702 can store an operating system and other application programs. When implementing the technical solutions provided by the embodiments of this specification through software or firmware, the relevant program codes are stored in the memory 702 and are called by the processor 701 to execute the blood pressure monitoring and control method based on the ionophoresis effect of microhole electrodes of the embodiments of the present application;

[0174] An input / output interface 703, which is used to implement information input and output;

[0175] A communication interface 704, which is used to implement communication interaction between this device and other devices, and can achieve communication through wired means (such as USB, network cable, etc.) or wireless means (such as mobile network, WIFI, Bluetooth, etc.);

[0176] A bus 705, which transmits information between various components of the device (such as the processor 701, the memory 702, the input / output interface 703, and the communication interface 704);

[0177] Among them, the processor 701, the memory 702, the input / output interface 703, and the communication interface 704 are communicatively connected to each other inside the device through the bus 705.

[0178] The embodiments of the present application also provide a computer-readable storage medium, which stores a computer program. When the computer program is executed by a processor, it implements the above-mentioned blood pressure monitoring and control method based on the ionophoresis effect of microhole electrodes.

[0179] It can be understood that the content in the above method embodiments is applicable to this storage medium embodiment. The functions specifically implemented in this storage medium embodiment are the same as those in the above method embodiments, and the beneficial effects achieved are also the same as those in the above method embodiments.

[0180] As a non-transitory computer-readable storage medium, the memory can be used to store non-transitory software programs and non-transitory computer-executable programs. In addition, the memory may include high-speed random access memory, and may also include non-transitory memory, such as at least one magnetic disk storage device, a flash memory device, or other non-transitory solid-state storage devices. In some embodiments, the memory optionally includes a memory remotely disposed relative to the processor, and these remote memories can be connected to the processor through a network. Examples of the above networks include, but are not limited to, the Internet, an enterprise intranet, a local area network, a mobile communication network, and combinations thereof.

[0181] A blood pressure monitoring and control device and method based on the ionophoresis effect of a microporous electrode provided in an embodiment of the present application can dynamically monitor the blood pressure index of a user by collecting pulse wave signals and electrocardiogram signals in real time and calculating the blood pressure index in real time. When the blood pressure index is abnormal, it can automatically perform drug delivery treatment through the ionophoresis effect of the microporous electrode according to the drug delivery control instruction sent by the mobile terminal, which helps to safely and accurately regulate the user's blood pressure and improve the user experience.

[0182] The embodiments described in the embodiments of the present application are for more clearly illustrating the technical solutions of the embodiments of the present application, and do not constitute a limitation on the technical solutions provided by the embodiments of the present application. Those skilled in the art know that with the evolution of technology and the emergence of new application scenarios, the technical solutions provided by the embodiments of the present application are equally applicable to similar technical problems.

[0183] Those skilled in the art can understand that the technical solutions shown in the figures do not constitute a limitation on the embodiments of the present application, and may include more or fewer steps than those shown, or combine certain steps, or different steps.

[0184] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separated, that is, they may be located in one place, or may be distributed to multiple network units. Some or all of the modules can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0185] Those of ordinary skill in the art can understand that all or some of the steps in the methods disclosed above, and the functional modules / units in the systems and devices, can be implemented as software, firmware, hardware, and appropriate combinations thereof.

[0186] In the description of this application and the above-mentioned drawings, terms such as "first", "second", "third", "fourth", etc. (if any) are used to distinguish similar objects and do not necessarily describe a specific order or sequence. It should be understood that the data used in this way can be interchanged under appropriate circumstances so that the embodiments of this application described here can be implemented in an order different from those illustrated or described here. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or device that includes a series of steps or units does not necessarily have to be limited to those steps or units clearly listed, but may include other steps or units not clearly listed or inherent to these processes, methods, products, or devices.

[0187] It should be understood that in this application, "at least one (item)" means one or more, and "a plurality" means two or more. "And / or" is used to describe the association relationship of associated objects and indicates that there can be three relationships. For example, "A and / or B" can mean: only A exists, only B exists, and both A and B exist at the same time. Among them, A and B can be singular or plural. The character " / " generally means that the associated objects before and after are in an "or" relationship. "At least one (one) of the following" or its similar expressions refer to any combination of these items, including any combination of single items (ones) or plural items (ones). For example, at least one (one) of a, b, or c can mean: a, b, c, "a and b", "a and c", "b and c", or "a and b and c", where a, b, and c can be single or multiple.

[0188] In several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are only illustrative. For example, the above-mentioned division of units is only a logical function division. In actual implementation, there can be other division methods. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed coupling, direct coupling, or communication connection to each other can be through some interfaces. The indirect coupling or communication connection of devices or units can be in electrical, mechanical, or other forms.

[0189] The units described above as separate components may or may not be physically separated. The components displayed as units may or may not be physical units, that is, they can be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0190] In addition, in each embodiment of the present application, each functional unit may be integrated into one processing unit, may exist separately as individual physical units, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of a software functional unit.

[0191] If the integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it may be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present application, in essence, or the part that contributes to the prior art, or all or part of the technical solution, may be embodied in the form of a software product. The computer software product is stored in a storage medium and includes multiple instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods in each embodiment of the present application. The foregoing storage medium includes: various media that can store programs such as USB flash drives, mobile hard disks, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical discs.

[0192] The preferred embodiments of the embodiments of the present application have been described above with reference to the accompanying drawings, and thus do not limit the scope of the rights of the embodiments of the present application. Any modifications, equivalent replacements, and improvements made by those skilled in the art without departing from the scope and essence of the embodiments of the present application shall be within the scope of the rights of the embodiments of the present application.

Claims

1. A blood pressure monitoring and control device based on microporous electrode ionophoresis effect, characterized in that: The device comprises: a signal acquisition module, a signal modulation module, a single chip computer system module, a signal transmission module and a drug delivery module; The signal acquisition module is used to acquire signals, and the signal acquisition module includes a pulse acquisition module for acquiring pulse wave signals and an electrocardiogram acquisition module for acquiring electrocardiogram signals; The signal modulation module is wirelessly connected to the signal acquisition module and is used to process the acquired signal; The single-chip system module is used to receive the pulse wave signal and the electrocardiogram signal after signal processing; and is also used to calculate the blood pressure index according to the pulse wave signal and the electrocardiogram signal after signal processing; The signal transmission module is used to transmit the processed pulse wave signal and electrocardiogram signal and the blood pressure index calculation result to the mobile terminal; and is also used to receive the drug delivery control instruction issued by the mobile terminal; The drug delivery module is used to deliver blood pressure therapeutic drugs through the microporous electrode ionophoresis effect.

2. The blood pressure monitoring and control device based on microporous electrode ionophoresis effect according to claim 1 is characterized in that: The pulse collection module comprises: a polyester substrate and a micro-nano needle structure; The polyester substrate is deposited with a metal conductive layer; The micro-nano needle structure comprises a first micro-needle structure prepared from a polydimethylsiloxane substrate, a zinc oxide layer nano-needle structure is grown on the surface of the first micro-needle structure, and a metal conductive layer is deposited on the surface of the zinc oxide layer nano-needle structure.

3. The blood pressure monitoring and control device based on microporous electrode ionophoresis effect according to claim 1, characterized in that: The ECG acquisition module is obtained by packaging and integrating at least one second microneedle structure; The second microneedle structure is prepared from a polydimethylsiloxane substrate; a metal conductive layer is deposited on the surface of the second microneedle structure.

4. The blood pressure monitoring and control device based on microporous electrode ionophoresis effect according to claim 1, characterized in that: The drug delivery module includes a working electrode terminal microneedle structure and a counter electrode terminal microneedle structure; The working electrode terminal microneedle structure comprises a hydrogel substrate containing a blood pressure treatment drug, a flexible gold electrode is embedded on one side of the hydrogel substrate, and a microneedle structure with mesopores is formed on the other side of the hydrogel substrate; The counter electrode microneedle structure comprises a hydrogel substrate, a flexible gold electrode is embedded on one side of the hydrogel substrate, and a microneedle structure with mesopores is formed on the other side of the hydrogel substrate.

5. A blood pressure monitoring and control method based on microporous electrode ionophoresis effect, characterized in that: The method comprises the following steps: Collect pulse wave signals and ECG signals; Performing signal processing on the pulse wave signal and the electrocardiogram signal, thereby calculating a blood pressure index based on the pulse wave signal and the electrocardiogram signal after the signal processing; Transmitting the processed pulse wave signal and electrocardiogram signal and the blood pressure index calculation result to the mobile terminal, and receiving the drug delivery control instruction issued by the mobile terminal; determining an open or closed state of a drug delivery module according to the drug delivery control instruction; The pulse wave signal is acquired by the pulse acquisition module, and the electrocardiogram signal is acquired by the electrocardiogram acquisition module; when the drug delivery module is in the on state, the blood pressure therapeutic drug is delivered through the microporous electrode ionophoresis effect.

6. The blood pressure monitoring and control method based on microporous electrode ionophoresis effect according to claim 5 is characterized in that: The pulse collection module is prepared by the following steps: A first microneedle structure is prepared on a flexible polydimethylsiloxane substrate by photolithography and centrifugal molding; Growing a zinc oxide layer nanoneedle structure on the surface of the first microneedle structure by a hydrothermal growth method; Depositing a metal conductive layer on the surface of the zinc oxide layer nanoneedle structure by magnetron sputtering to obtain a micro-nano needle structure; Depositing a metal conductive layer on the polyester substrate by magnetron sputtering to obtain a prepared polyester substrate; The micro-nano needle structure and the prepared polyester substrate are packaged to obtain the pulse collection module.

7. The blood pressure monitoring and control method based on microporous electrode ionophoresis effect according to claim 5, characterized in that: The electrocardiogram acquisition module is prepared by the following steps: A second microneedle structure is prepared on a flexible polydimethylsiloxane substrate by photolithography and centrifugal molding; Depositing a metal conductive layer on the surface of the second microneedle structure by magnetron sputtering; Performing insulation treatment on the substrate of the second microneedle structure to obtain a microneedle electrode; At least one of the microneedle electrodes is packaged and integrated to obtain an electrocardiogram acquisition module.

8. The blood pressure monitoring and control method based on microporous electrode ionophoresis effect according to claim 5, characterized in that: The drug delivery module is prepared by the following steps: Prepare microneedle structure mold by photolithography and centrifugal molding; A microneedle structure is prepared by using polyethylene glycol diacrylate and a microneedle structure mold, and zinc oxide nanowires are doped at the tip of the microneedle structure, and the tip of the microneedle structure is immersed in an acidic solution to dissolve the zinc oxide nanowires and form mesopores, thereby obtaining a microneedle structure with mesopores; A hydrogel substrate is prepared by using polyethylene glycol diacrylate, and a blood pressure therapeutic drug is loaded inside the hydrogel substrate; Embedding a flexible gold electrode in the hydrogel substrate and performing demoulding treatment to obtain a working electrode terminal microneedle structure; Prepare microneedle structure mold by photolithography and centrifugal molding; A microneedle structure is prepared by using polyethylene glycol diacrylate and a microneedle structure mold, and zinc oxide nanowires are doped at the tip of the microneedle structure, and the tip of the microneedle structure is immersed in an acidic solution to dissolve the zinc oxide nanowires and form mesopores, thereby obtaining a microneedle structure with mesopores; A hydrogel substrate is prepared by using polyethylene glycol diacrylate, a flexible gold electrode is embedded in the hydrogel substrate, and a demolding process is performed to obtain a microneedle structure at the electrode end; Encapsulating the working electrode terminal microneedle structure and the counter electrode terminal microneedle structure to obtain the drug delivery module; Wherein, the microneedle structure with mesopores and the flexible gold electrode are on both sides of the hydrogel substrate.

9. An electronic device, characterized in that: The electronic device includes a memory and a processor, the memory stores a computer program, and the processor implements the blood pressure monitoring and control method based on the microporous electrode ionophoresis effect as described in any one of claims 5 to 8 when executing the computer program.

10. A computer-readable storage medium storing a computer program, characterized in that: When the computer program is executed by a processor, the blood pressure monitoring and control method based on the microporous electrode ionophoresis effect according to any one of claims 5 to 8 is implemented.

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