Oral composition

Abstract

Provided is an oral composition having excellent fluorine ion retention properties and low mucosal irritation. An oral composition containing component (A): sodium fluoride; component (B): a water-soluble calcium salt; component (C): at least one selected from the group consisting of pyrophosphoric acid and alkali metal salts thereof; component (D): at least one anionic surfactant selected from the group consisting of N-acyl taurine salts, N-acyl amino acid salts, and alpha-olefin sulfonates.

Description

Technical Field

[0001] The present invention relates to an oral composition. Background Art

[0002] Fluorides such as sodium fluoride are widely used as medicinal ingredients in oral compositions such as dentifrices because of their effect of preventing dental caries. In order for a fluorine-containing compound to act effectively, it is effective to retain fluoride ions in the mucous membranes and tooth surfaces in the oral cavity for a long time, and it is desired that a relatively large amount of fluoride ions remain in the oral cavity even after rinsing the oral cavity with water or the like after use. In Patent Document 1, as an oral composition having high fluoride ion retention in the oral cavity, a composition containing a complex formed in an aqueous solution containing a polyphosphate, a calcium salt, and a fluoride salt is disclosed. [Prior Art Documents] [Patent Documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2009-137863 Summary of the Invention [Problems to be Solved by the Invention]

[0004] Anionic surfactants are widely used in oral compositions because of their higher detergency and foaming power compared with nonionic surfactants or amphoteric surfactants. Patent Document 1 also discloses an oral composition containing the above complex and an anionic surfactant, sodium lauryl sulfate. However, according to the research of the present inventors, there is still room for improvement in the mucosal irritation during use of an oral composition containing the above complex and sodium lauryl sulfate. Further, when the oral composition is toothpaste, there is room for improvement in the surface of the toothpaste after storage at low temperature.

[0005] An object of the present invention is to provide an oral composition having excellent fluoride ion retention and low mucosal irritation. [Means for Solving the Problems]

[0006] As a result of intensive studies by the present inventors, it has been found that by combining sodium fluoride, a water-soluble calcium salt, pyrophosphoric acid or its alkali metal salt, and a specific anionic surfactant, it is possible to improve fluoride ion retention while suppressing mucosal irritation, and further to suppress deterioration of the toothpaste surface during storage at low temperature. The present invention is an invention based on the above findings and has the following aspects.

[0007] <1> An oral composition containing (A) component: sodium fluoride; (B) component: a water-soluble calcium salt; (C) Component: at least one selected from pyrophosphoric acid and its alkali metal salts; and (D) Component: at least one anionic surfactant selected from N-acyl taurates, N-acyl amino acid salts, and α-olefin sulfonates. <2> In the oral composition according to <1>, the (B) component is at least one selected from calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate. <3> In the oral composition according to <1> or <2>, the (C) component is at least one selected from pyrophosphoric acid, sodium pyrophosphate, and potassium pyrophosphate. <4> In the oral composition according to any one of <1> to <3>, the (D) component is at least one selected from N-acyl methyl taurates and N-acyl sarcosinates. <5> In the oral composition according to any one of <1> to <4>, the (D) component is at least one selected from sodium N-lauroyl methyl taurate and sodium N-lauroyl sarcosinate. <6> In the oral composition according to any one of <1> to <5>, when the molar amount (mmol) of the (B) component in each 1 g of the oral composition is set as B mmοl , and the mass ratio (mass %) of the (D) component to the total mass of the oral composition is set as D wt％ , the ratio represented by B mmοl / D wt％ is 0.01 to 2.7. <7> In the oral composition according to any one of <1> to <6>, the oral composition is toothpaste.

Advantages of the Invention

[0008] According to the present invention, an oral composition excellent in fluoride ion retention and low mucosal irritation can be provided. Detailed Embodiments

[0009] In this specification, an "oral composition" refers to a composition mainly intended for use in the oral cavity. "Water-soluble" means a solubility in water at 20 °C of 1 g / 100 g or more. The "~" indicating a numerical range means including the values described before and after it as the lower limit value and the upper limit value.

[0010] 〔Oral Composition〕 The oral composition of the present invention contains component (A), component (B), component (C) and component (D).

[0011] <Component (A)> Component (A) is sodium fluoride (NaF). Since the oral composition contains component (A), it has excellent fluoride ion retention and low mucosal irritation. Commercially available products can be used as component (A).

[0012] <Component (B)> Component (B) is a water-soluble calcium salt. Since the oral composition contains component (B), it has excellent fluoride ion retention and low mucosal irritation.

[0013] Examples of component (B) include calcium chloride, calcium nitrate, calcium acetate, calcium citrate, calcium glycerophosphate, calcium gluconate, calcium benzoate, calcium formate, calcium fumarate, calcium lactate, calcium butyrate, calcium isobutyrate, calcium malate, calcium maleate, calcium propionate, calcium valerate, calcium pantothenate, etc. As component (B), at least one selected from calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate and calcium pantothenate is preferred. Component (B) can be a single kind or a combination of two or more kinds. Commercially available products can be used as component (B).

[0014] <Component (C)> Component (C) is at least one selected from pyrophosphoric acid and its alkali metal salts. Since the oral composition contains component (C), it has excellent fluoride ion retention and an excellent toothpaste surface after storage at low temperature.

[0015] Examples of the alkali metal salts include sodium salts and potassium salts. From the viewpoint of fluoride ion retention, as component (C), at least one selected from pyrophosphoric acid, sodium pyrophosphate and potassium pyrophosphate is preferred, and at least one selected from potassium pyrophosphate and sodium pyrophosphate is particularly preferred. Component (C) can be a single kind or a combination of two or more kinds. Commercially available products can be used as component (C).

[0016] <Component (D)> Component (D) is at least one anionic surfactant selected from N-acyl taurates, N-acyl amino acid salts and α-olefin sulfonates. Since the oral composition contains component (D), it has excellent fluoride ion retention, low mucosal irritation and an excellent toothpaste surface after storage at low temperature.

[0017] The number of carbon atoms of the acyl group in the N-acyl taurate is preferably 10 to 20. As the salt, alkali metal salts such as sodium salt and potassium salt are preferred, and sodium salt is more preferred. Examples of the N-acyl taurate include N-acylmethyl taurates such as sodium N-cocoylmethyl taurate, potassium N-cocoylmethyl taurate, sodium N-lauroylmethyl taurate, sodium N-stearoylmethyl taurate, sodium N-myristoylmethyl taurate, sodium N-oleoylmethyl taurate, and sodium N-palmitoylmethyl taurate, and sodium N-cocoyl taurate. Among them, N-acylmethyl taurates are preferred, and sodium N-acylmethyl taurate is more preferred.

[0018] The number of carbon atoms of the acyl group in the N-acyl amino acid salt is preferably 8 to 18, more preferably 10 to 16. As the salt, alkali metal salts such as sodium salt and potassium salt are preferred, and sodium salt is more preferred. Examples of the N-acyl amino acid salt include N-acyl acidic amino acid salts such as N-acyl glutamate and N-acyl aspartate; N-acyl neutral amino acid salts such as N-acyl sarcosinate, N-acyl methylalaninate, N-acyl glycinate, and N-acyl alaninate; and acyl basic amino acid salts such as N-acyl arginine ethyl ester salt. Among them, N-acyl neutral amino acid salts are preferred, and N-acyl sarcosinate is more preferred. As the N-acyl sarcosinate, a substance having an acyl group with the above-mentioned number of carbon atoms is preferred. Examples include N-cocoyl sarcosinate, N-lauroyl sarcosinate, and N-palmitoyl sarcosinate. Among them, sodium N-lauroyl sarcosinate is preferred.

[0019] The number of carbon atoms of the α-olefin sulfonate is preferably 8 to 18, more preferably 14 to 16. As the salt, alkali metal salts such as sodium salt and potassium salt are preferred, and sodium salt is more preferred. As the α-olefin sulfonate, an α-olefin sulfonate having 14 carbon atoms, particularly a sodium salt (common name: sodium tetradecene sulfonate), is preferred.

[0020] As the component (D), from the aspect of more excellent low mucosal irritation, at least one selected from N-acyl taurates and N-acyl amino acid salts is preferred, at least one selected from N-acylmethyl taurates and N-acyl sarcosinates is more preferred, and at least one selected from sodium N-lauroylmethyl taurate and sodium N-lauroyl sarcosinate is further preferred. The component (D) can be a single kind or a combination of two or more kinds. The component (D) can use commercially available products.

[0021] <Content of each component> The content of component (A) is preferably 0.09 to 1.3% by mass, more preferably 0.10 to 1.1% by mass, based on the total mass of the oral composition. When the content of component (A) is at least the above lower limit value, the fluoride ion retention and low mucosal irritation are more excellent. When the content of component (A) is at most the above upper limit value, the surface of the toothpaste after low-temperature storage is more excellent.

[0022] The content of component (B) is preferably 0.02 to 5.0% by mass, more preferably 0.03 to 3.0% by mass, based on the total mass of the oral composition. When the content of component (B) is at least the above lower limit value, the fluoride ion retention and low mucosal irritation are more excellent. When the content of component (B) is at most the above upper limit value, the fluoride ion retention and the surface of the toothpaste after low-temperature storage are more excellent.

[0023] The content of component (C) is preferably 0.02 to 3.0% by mass, more preferably 0.03 to 1.3% by mass, based on the total mass of the oral composition. When the content of component (C) is at least the above lower limit value, the fluoride ion retention and the surface of the toothpaste after low-temperature storage are more excellent. When the content of component (C) is at most the above upper limit value, the low mucosal irritation is more excellent.

[0024] The content of component (D) is preferably 0.001 to 10% by mass, more preferably 0.1 to 5% by mass, based on the total mass of the oral composition. When the content of component (D) is at least the above lower limit value, the fluoride ion retention and the paste appearance after low-temperature storage are more excellent. When the content of component (D) is at most the above upper limit value, the fluoride ion retention and low mucosal irritation are more excellent. (D) component content is preferably such that the ratio represented by B mmοl / D wt％ is within the following preferred range.

[0025] Let the molar amount (mmol) of component (B) in 1 g of the oral composition be B mmοl , and let the mass ratio (% by mass) of component (D) to the total mass of the oral composition be D wt％ . When the ratio represented by B mmοl / D wt％ is preferably 0.01 to 2.7, more preferably 0.03 to 2.3. When B mmοl / D wt％ is at least the above lower limit value, the fluoride ion retention and low mucosal irritation are more excellent. When B mmοl / D wt％ is at most the above upper limit value, the fluoride ion retention and the surface of the toothpaste after low-temperature storage are more excellent.

[0026] The molar ratio of component (B) to component (A) (hereinafter also referred to as "(B) / (A)") is preferably from 0.005 to 10.0, more preferably from 0.01 to 5.0. When (B) / (A) is at or above the above lower limit value, the fluoride ion retention property and low mucosal irritation are more excellent. When (B) / (A) is at or below the above upper limit value, the fluoride ion retention property and the paste-like appearance after low-temperature storage are more excellent.

[0027] The molar ratio of component (C) to component (A) (hereinafter also referred to as "(C) / (A)") is preferably from 0.005 to 2.1, more preferably from 0.01 to 2.1. When (C) / (A) is within the above range, the fluoride ion retention property is more excellent.

[0028] <Other components> Within the range that does not hinder the effects of the present invention, the oral composition of the present invention may further contain other components other than component (A), component (B), component (C) and component (D) as needed. Other components can be appropriately selected from known components in consideration of the dosage form, usage method, etc. of the oral composition. Examples of other components include water, abrasives, binders, thickeners, surfactants other than component (D), colorants, sweeteners, preservatives, fragrances, active ingredients, pH regulators.

[0029] As abrasives, for example, silica-based abrasives such as anhydrous silicic acid, precipitated silica, silica gel, aluminosilicate, zirconium silicate, dicalcium phosphate dihydrate or anhydrate, calcium dihydrogen phosphate, calcium phosphate, quaternary calcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, magnesium phosphate tribasic, magnesium carbonate can be cited. From the aspect of the manifestation of the effects of the present invention, silica-based abrasives are particularly preferred. The content of the abrasive is preferably from 0 to 60% by mass, more preferably from 0 to 30% by mass, based on the total mass of the oral composition, and may also be 25% by mass or less. A content of 0% by mass of the abrasive means that no abrasive is contained.

[0030] As binders, for example, organic binders such as water-soluble polymer substances selected from cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, gums such as xanthan gum, tragacanth gum, karaya gum, gum arabic, and polyacrylates such as sodium polyacrylate can be cited; inorganic binders such as thickening silica, thickening aluminum silica, magnesium aluminum silicate (veegum), laponite. The content of the binder is preferably 0.05 to 13.0% by mass relative to the total mass of the oral composition. When the binder contains an organic binder, the blending amount of the organic binder is more preferably 0.1 to 3% by mass relative to the total mass of the oral composition, and further preferably 0.5 to 2.5% by mass. When the binder contains an inorganic binder, from the aspect of the adsorbability of fluoride ions to the tooth surface, the content of the inorganic binder is more preferably 0 to 10.0% by mass relative to the total mass of the oral composition, and further preferably 0 to 8.0% by mass.

[0031] Examples of the thickener include sugar alcohols such as sorbitol, xylitol, erythritol, and maltitol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol having an average molecular weight of 160 to 400 (average molecular weight described in the Standards for Raw Materials for Quasi-Drugs 2006). The content of the thickener is preferably 20 to 70% by mass relative to the total mass of the oral composition, and more preferably 25 to 65% by mass.

[0032] Examples of the surfactant other than the component (D) include nonionic surfactants, anionic surfactants other than the component (D), and amphoteric surfactants. Examples of the nonionic surfactant include glycerol fatty acid esters such as decaglycerol laurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate (average number of moles of ethylene oxide added (hereinafter simply referred to as "E.O.") 20), alkyl glycosides having 12 to 16 carbon atoms in the alkyl group, sorbitan fatty acid esters such as sorbitan tristearate, sucrose fatty acid esters such as sucrose laurate, and polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether (E.O. 6). Examples of the anionic surfactant other than the component (D) include alkyl sulfates such as sodium dodecyl sulfate and sodium tetradecyl sulfate, and sodium dodecylbenzenesulfonate and sodium lauryl sulfoacetate. Examples of the amphoteric surfactant include coconut fatty acid amide propyl betaine, lauryl dimethylaminoacetic acid betaine, and N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine. The content of the surfactant other than the component (D) is, for example, 0 to 8.0% by mass relative to the total mass of the oral composition. From the viewpoint of low irritation to the mucosa, the oral composition preferably does not contain an anionic surfactant other than the component (D).

[0033] Examples of the coloring agent include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3, mica titanium, and titanium oxide. Examples of the sweetener include sodium saccharin, aspartame, stevioside, stevia extract, p-methoxycinnamaldehyde, neohesperidin dihydrochalcone, and perillartine. Examples of the preservative include p-hydroxybenzoic acid esters such as methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, and butyl p-hydroxybenzoate, and benzoic acid or its salts such as sodium benzoate.

[0034] Examples of the fragrance include natural fragrances such as peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, tangerine oil, pearberry oil, lavender oil, rosemary oil, bayberry oil, chamomile oil, caraway oil, marjoram oil, bay leaf oil, lemongrass oil, oregano oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, pomelo oil, shaddock oil, orris absolute, peppermint absolute, rose absolute, neroli absolute, and the like, or fragrances obtained by processing these natural fragrances (such as removal of the fore fraction, removal of the after fraction, fractional distillation, liquid-liquid extraction, rectification, powdering of the fragrance, etc.), single-component fragrances such as menthol, carvone, anethole, eucalyptol, methyl salicylate, cinnamaldehyde, eugenol, 3-l-methoxy-1,2-propanediol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, piperitone, diethylene glycol monoethyl ether acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexanepropionate, methyl anthranilate, ethyl methylphenylglycidate, vanillin, undecanolide, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methylcyclopentenolone, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate, and the like, and blended fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, mixed fruit flavor, tropical fruit flavor, and the like. Known fragrance raw materials can be used in combination as the fragrance for the oral composition. The content of the fragrance is not particularly limited. The content of the above fragrance raw materials is preferably 0.000001 to 1% by mass based on the total mass of the oral composition. The content of the fragrance for imparting fragrance using the above fragrance materials is preferably 0.05 to 2% by mass based on the total mass of the oral composition.

[0035] As active ingredients, for example, fungicides such as isopropylmethylphenol and cetylpyridinium chloride, water-soluble phosphoric acid compounds such as potassium salts and sodium salts of orthophosphoric acid (excluding component (C)), enzymes such as dextranase, mutanase, amylase, and protease, tranexamic acid, ε-aminocaproic acid, triclosan, lysozyme chloride, allantoin aluminum hydroxychloride, hinokitiol, ascorbic acid, tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene or sodium copper chlorophyllin, chlorophyll, water-soluble copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid or its derivatives, glycyrrhizic acid or its salts, glycyrrhetinic acid or its derivatives, and tartar inhibitors. Within the range that does not interfere with the effects of the present invention, an effective amount of the above active ingredients can be mixed.

[0036] As pH adjusters, for example, citric acid, tartaric acid, malic acid or their salts such as potassium salts and sodium salts, and sodium hydroxide can be mentioned.

[0037] <Form, dosage form> The oral composition can be prepared in various forms such as liquid, paste, and solid. The dosage form of the oral composition is not particularly limited. The dosage form of the oral composition is typically an oral preparation that is discharged from the oral cavity after use. As oral preparations, for example, dentifrices (liquid dentifrices, liquid dentifrices, toothpastes, wet powder dentifrices, powder dentifrices, etc.), oral cleansers, mouthwashes, coating agents, mouth sprays, patches, tablets, sustained-release agents in the oral cavity, chewing agents, dissolving agents in the oral cavity, disintegrating agents in the oral cavity, tongue care agents, oral cooling agents, denture care agents, etc. can be mentioned. Among the above, the oral composition of the present invention is preferably used as a dentifrice, and particularly preferably as a toothpaste.

[0038] The oral composition of the present invention can be prepared by a known method. For example, it can be prepared by mixing component (A), component (B), component (C), and component (D) and other components as needed by a conventional method.

[0039] It is preferable that fluoride ions, calcium ions, and phosphate ions form a complex in the oral composition. When the above complex is formed, the retention of fluoride ions in the oral cavity is improved, and thus, the adsorption of fluoride ions to the tooth surface is further improved.

[0040] The formation of the above complex can be confirmed by observing the crystal size based on X-ray crystal structure analysis and the exothermic peak when the crystal water near the phosphate group dissociates at around 450 °C based on calorimetry (TG-DTA measurement). That is, when the complex is formed, due to the attribution to CaF 2The crystallite size determined from the diffraction peaks becomes less than 10 nm through the complexation of phosphate groups. In addition, the peak indicating the generation of crystal water shows that CaF seen through X-ray crystal structure analysis 2 is not a crystal composed only of calcium and fluoride ions, but a complex in which phosphate groups interact. Specifically, the formation of the complex can be confirmed by confirming that the crystallite size is less than 10 nm by the following method (1) and confirming the presence of an exothermic peak at 450 °C by the following method (2). (1) Crystallite size Measure the sample with an X-ray structure diffraction apparatus (light source Cu: Kα, 40 kV, 20 mA, divergence slit 1 / 2 deg, scattering slit 1 / 2 deg, receiving slit 0.15 mm, scanning speed 4.000 ° / min, 2θ = 2.000 - 80.000 °), calculate the crystallite size according to the following formula (Scherrer's formula), and evaluate the formation of the complex. L = Kλ / (βcosθ) L: crystallite size, K: coefficient 0.9, β: full width at half maximum, λ: θ: diffraction angle (2) TG-DTA measurement (exothermic peak) Heating rate: 5 °C / min, measurement range: 25 °C to 600 °C

[0041] As a method for forming the above complex, there is no particular limitation. When preparing an oral composition, for example, it is preferably any one of the steps of mixing component (B) after mixing components (A) and (C), and mixing component (A) after mixing components (B) and (C). In addition, when components (A) and (B) are mixed simultaneously, a part of calcium fluoride is generated, and the formation efficiency of the complex may deteriorate.

[0042] The oral composition described above contains components (A), (B), (C), and (D), and thus has excellent fluoride ion retention and low mucosal irritation.

Examples

[0043] The following examples specifically illustrate the present invention, but the present invention is not limited to the following description. In addition, in the following examples, unless otherwise specified, "%" means "mass %".

[0044] <Raw materials used> Sodium fluoride: manufactured by Stella Chemical Co., Ltd. Also referred to as "NaF" below. Calcium chloride: manufactured by Tomita Pharmaceutical Co., Ltd. Also referred to as "CaCl" below. Calcium gluconate: manufactured by Fuso Chemical Industry Co., Ltd. Also referred to as "Ca gluconate" below. Calcium lactate hydrate: manufactured by Taihei Chemical Industry Co., Ltd., trade name "Calcium Lactate". Also referred to as "Ca Lactate" hereinafter. Calcium glycerophosphate: manufactured by Iwaki Pharmaceutical Co., Ltd. Also referred to as "Ca Glycerophosphate" hereinafter. Calcium pantothenate: manufactured by BASF. Also referred to as "Ca Pantothenate" hereinafter. Potassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd. Also referred to as "K Pyrophosphate" hereinafter. Sodium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd., trade name "Sodium Pyrophosphate (Anhydrous)". Also referred to as "Na Pyrophosphate" hereinafter. Sodium tripolyphosphate: manufactured by Taihei Chemical Industry Co., Ltd. Also referred to as "Na Tripolyphosphate" hereinafter. Sodium lauroyl sarcosinate: manufactured by Nikko Chemicals Co., Ltd., trade name "NIKKOL SARCOSINATE LN". Also referred to as "Na Lauroyl Sarcosinate" hereinafter. Sodium lauroyl methyl taurate: manufactured by Nikko Chemicals Co., Ltd., trade name "NIKKOLLMT-P". Also referred to as "Na Lauroyl Methyl Taurate" hereinafter. Sodium myristoleate sulfonate: manufactured by Lion Specialty Chemical Co., Ltd., trade name "LIPOLAN LB-440 (Liquid)". Sodium lauroyl glutamate: manufactured by Asahi Kasei Chemicals Corporation. Sodium cocoyl glutamate: manufactured by Asahi Kasei Fine Chemicals Corporation. Sodium palmitoyl sarcosinate: manufactured by Nikko Chemicals Co., Ltd. Sodium cocoyl methyl taurate: manufactured by NOF Corporation.

[0045] <Examples 1 to 30, Comparative Examples 1 to 6> Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 4 were prepared by conventional methods. The blank columns in the tables indicate that the component was not mixed. The "balance" of purified water represents the amount that makes the total amount of the dentifrice composition 100%. The following evaluations were performed on the obtained dentifrice compositions. The results are also shown in Tables 1 to 4.

[0046] (Evaluation of fluoride ion retention on tooth enamel) The liquid obtained by diluting the dentifrice composition 4-fold with purified water was applied to a 6×6 mm square slice made of bovine tooth enamel for 3 minutes, and then immediately washed 3 times with purified water. After drying the slice, it was treated with 120 μL of artificial saliva on the slice for 3 minutes, and the concentration (ppm) of the extracted fluoride ions was measured using an ion meter (Orion 1115000 4-Star, manufactured by Thermo Fisher Scientific Co., Ltd.). The average value of N = 3 was calculated and evaluated according to the following criteria. [Evaluation Criteria] ◎: 0.3 ppm or more. 〇: 0.2 ppm or more and less than 0.3 ppm. △: 0.1 ppm or more and less than 0.2 ppm. ×: Less than 0.1 ppm.

[0047] (Evaluation of Mucosal Irritation Degree) Using the conventional method, the dentifrice composition was used to evaluate the degree of irritation of the buccal mucosa after use in the oral cavity. Specifically, 10 subjects used the dentifrice composition by the following method, and the degree of irritation in the oral cavity after 10 minutes was evaluated according to the following 5-point scoring criteria. The average score of 10 people was calculated and judged using ◎, 〇, △, and × according to the following evaluation criteria. [Method of Using Dentifrice] Place 1 g of the dentifrice composition on a toothbrush, brush teeth for 2 minutes, spit it out, and then rinse the mouth with 50 mL of water. [Scoring Criteria] 5 points: No irritation at all. 4 points: Almost no irritation. 3 points: Slightly irritated. 2 points: Irritated. 1 point: Strongly irritated. [Evaluation Criteria] ◎: Average score of 4.5 points or more. 〇: Average score of 4.0 points or more and less than 4.5 points. △: Average score of 3.0 points or more and less than 4.0 points. ×: Average score of 1.0 points or more and less than 3.0 points.

[0048] (Evaluation of Toothpaste Surface) 50 g of each oral composition was separately filled into 3 tube containers (the innermost layer is a laminated tube with a diameter of 26 mm made of linear low-density polyethylene, manufactured by Dainippon Printing Co., Ltd.), and stored at -5°C for 1 month. At -5°C, squeeze out 15 cm × 3 strips of the dentifrice composition from the tubular container onto the evaluation paper. After bending the evaluation paper and slightly crushing the dentifrice composition, evaluate the toothpaste surface of the dentifrice composition when the paper is opened back to its original state using the following scoring criteria. Evaluate 3 tubular containers in the same manner, and determine the average score according to the following evaluation criteria using ◎, ○, △, and ×. [Scoring Criteria] 5 points: No wrinkles or particles, and the surface is shiny. 4 points: Slightly wrinkled, no shine. 3 points: Slightly wrinkled or with particles. 2 points: Wrinkles or particles are both confirmed. 1 point: Many wrinkles or particles are both confirmed, and the composition has no uniformity. [Evaluation Criteria] ◎: Average score is 4.6 or above. ○: Average score is above 4.3 and less than 4.6. △: Average score is above 4.1 and less than 4.3. ×: Average score is less than 4.1.

[0049]

Table 1

[0050]

Table 2

[0051]

Table 3

[0052]

Table 4

[0053] As shown in the above results, among the dentifrice compositions of Examples 1 to 30, the fluoride ion retention, mucosal irritation degree, and toothpaste surface during low-temperature storage are excellent. On the other hand, the fluoride ion retention and mucosal irritation degree of Comparative Example 1 without component (A) are poor. The fluoride ion retention and mucosal irritation degree of Comparative Example 2 without component (B) are poor. The fluoride ion retention of Comparative Example 3 without component (C) is poor. The fluoride ion retention and toothpaste surface during low-temperature storage of Comparative Example 4 without component (D) are poor. The fluoride ion retention and mucosal irritation degree of Comparative Example 5 containing sodium tripolyphosphate instead of component (C) are poor. The mucosal irritation degree of Comparative Example 6 containing sodium lauryl sulfate instead of component (D) is poor, and the toothpaste surface is also poor during low-temperature storage.

[0054] Next, formulation examples will be presented. An oral composition having the following composition is prepared by a conventional method. After evaluation by the same method as above, in any of the formulation examples, the fluoride ion retention and the mucosal irritation degree are excellent. For toothpaste, the toothpaste surface during low-temperature storage is also excellent.

[0055] <Formulation Example 1 Toothpaste>

[0056] <Formulation Example 2 Toothpaste>

[0057] <Formulation Example 3 Toothpaste>

[0058] <Formulation Example 4 Toothpaste>

[0059] <Formulation Example 5 Toothpaste>

[0060] <Formulation Example 6 Oral Cleanser>

Claims

1. An oral composition comprising (A) Ingredients: sodium fluoride; (B) ingredient: water-soluble calcium salt; (C) component: at least one selected from pyrophosphoric acid and alkali metal salts thereof; and Component (D): at least one anionic surfactant selected from the group consisting of N-acyltaurates, N-acylamino acid salts and α-olefin sulfonates.

2. The oral composition according to claim 1, wherein The component (B) is at least one selected from the group consisting of calcium chloride, calcium glycerophosphate, calcium gluconate, calcium lactate, and calcium pantothenate.

3. The oral composition according to claim 1, wherein The component (C) is at least one selected from the group consisting of pyrophosphoric acid, sodium pyrophosphate and potassium pyrophosphate.

4. The oral composition according to claim 1, wherein The component (D) is at least one selected from the group consisting of N-acyl methyl taurine and N-acyl sarcosinate.

5. The oral composition according to claim 1, wherein The component (D) is at least one selected from the group consisting of sodium N-lauroyl methyl taurate and sodium N-lauroyl sarcosinate.

6. The oral composition according to claim 1, wherein The molar amount of the component (B) per 1 g of the oral composition is defined as B mmοl , the mass ratio of the component (D) to the total mass of the oral composition is defined as D wt％ When B mmοl / D wt％ The ratio represented is 0.01 to 2.7, the unit of the molar amount is mmol, and the unit of the mass ratio is mass %.

7. The oral composition according to claim 1, wherein The content of the component (A) is 0.09 to 1.3% by mass, the content of the component (B) is 0.02 to 5.0% by mass, the content of the component (C) is 0.02 to 3.0% by mass, and the content of the component (D) is 0.001 to 10% by mass, based on the total mass of the oral composition.

8. The oral composition according to claim 1, wherein The molar ratio of the component (C) to the component (A) is 0.005 to 2.

1.

9. The oral composition according to any one of claims 1 to 8, wherein The oral composition is a toothpaste.

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