Multifunctional wound dressing as well as preparation method and application thereof

Abstract

The invention provides a multifunctional wound dressing as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The invention provides a multifunctional wound dressing which is prepared from a spinning solution through electrostatic spinning, and the spinning solution is prepared from the following components in concentration: 0.1 to 2.0 g / mL of PLGA-PEG-PLGA triblock polymer, 0.2 to 3.0 g / mL of biodegradable plastic, 0.1 to 6 wt% of calcium chloride, 0.1 to 6 wt% of sodium alginate, 0.01 to 4 wt% of dopamine hydrochloride and 0.1 to 12 wt% of oxygen releasing agent. The multifunctional wound dressing disclosed by the invention has good seepage absorption capacity, antibacterial property and hydrophilicity as well as good biocompatibility and degradability, and compared with other wound dressings, the multifunctional wound dressing disclosed by the invention is a multifunctional wound dressing.

Description

Technical Field

[0001] The present invention relates to the technical field of polymer materials, and particularly relates to a multifunctional wound dressing, a preparation method thereof, and an application thereof. Background Art

[0002] How to achieve rapid wound healing and antibacterial and anti-infection effects in skin wound dressings is a major challenge faced in clinical practice. In clinical practice, traditional dressings are mostly dry dressings, which have limited functions, limited ability to absorb exudate, and slow healing promotion. In recent years, some high-end wet dressings have gradually emerged. Common wet dressings include hydrogels, electrospun fibers, alginates, foam dressings, etc. Among them, electrospun fibers and hydrogel dressings are hot research topics in recent years.

[0003] As a wound dressing, electrospun fibers are beneficial for hemostasis, drug release, gas penetration due to their special structure, and can also absorb wound exudate to a certain extent. However, electrospun fiber membranes are usually relatively dense, with problems such as poor ability to absorb wound exudate and limited wound repair ability. Hydrogels are considered an ideal dressing due to their excellent physical and chemical properties, can provide additional moisture for the wound, absorb excessive exudate at the wound, cool the wound surface, and relieve pain. However, their mechanical properties are poor, the adhesion to the skin is weak, bacteria are easy to invade, and it is difficult to store for a long time. Microbial invasion can cause skin wound infection, and the overuse of antibiotics has led to an increasingly serious problem of drug resistance, making it particularly urgent to find new antibacterial strategies.

[0004] There is an urgent need for a multifunctional wound dressing that can absorb wound exudate, effectively antibacterial, and promote wound healing. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a multifunctional wound dressing, a preparation method thereof, and an application thereof. The multifunctional wound dressing provided by the present invention can absorb wound exudate, effectively antibacterial, and promote wound healing.

[0006] To achieve the above-mentioned invention purpose, the present invention provides the following technical solutions:

[0007] The present invention provides a multifunctional wound dressing, which is prepared by electrospinning a spinning solution. The spinning solution includes components with the following concentrations: 0.1 - 2.0 g / mL of PLGA-PEG-PLGA triblock polymer, 0.2 - 3.0 g / mL of biodegradable plastic, 0.1 - 6 wt% of calcium chloride, 0.1 - 6 wt% of sodium alginate, 0.01 - 4 wt% of hydrochloric acid dopamine, and 0.1 - 12 wt% of oxygen releasing agent.

[0008] Preferably, the spinning solution comprises components with the following concentrations: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of biodegradable plastic, 4 wt% of calcium chloride, 4 wt% of sodium alginate, 2-4 wt% of dopamine hydrochloride, and 4-6 wt% of oxygen releasing agent.

[0009] Preferably, the biodegradable plastic comprises one or more of a copolymer of butylene adipate and butylene terephthalate, polycaprolactone, and poly(butylene succinate-co-butylene terephthalate).

[0010] Preferably, the oxygen releasing agent comprises peroxide and / or percarbonate.

[0011] Preferably, the peroxide comprises one or several of sodium peroxide, lithium peroxide, potassium peroxide, calcium peroxide, magnesium peroxide, and barium peroxide; the percarbonate comprises sodium percarbonate and / or potassium percarbonate.

[0012] Preferably, the spinning solution further contains a solvent, and the solvent comprises chloroform.

[0013] Preferably, the average molecular weight of the PLGA-PEG-PLGA triblock polymer is 9000 g / mol.

[0014] The present invention also provides a preparation method of the multifunctional wound dressing according to the above technical solution. Electrospinning the spinning solution to obtain the multifunctional wound dressing.

[0015] Preferably, the voltage of the electrospinning is 10-14 kV, and the feeding speed is 0.001-0.04 mm / s.

[0016] The present invention also provides the application of the multifunctional wound dressing according to the above technical solution or the multifunctional wound dressing prepared by the preparation method according to the above technical solution in the preparation of a skin wound dressing.

[0017] The present invention provides a multifunctional wound dressing, which is prepared by electrospinning a spinning solution. The spinning solution comprises components with the following concentrations: 0.1-2.0 g / mL of PLGA-PEG-PLGA triblock polymer, 0.2-3.0 g / mL of biodegradable plastic, 0.1-6 wt% of calcium chloride, 0.1-6 wt% of sodium alginate, 0.01-4 wt% of dopamine hydrochloride, and 0.1-12 wt% of oxygen releasing agent. The multifunctional wound dressing of the present invention has good exudate absorption ability, antibacterial property, hydrophilicity, as well as good biocompatibility and degradability. Compared with other wound dressings, it is a multifunctional wound dressing.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0019] 1. Good absorbent and exudate-absorbing capacity, hydrophilicity: Dopamine hydrochloride was added to the polymer electrospun substrate (including PLGA-PEG-PLGA triblock polymer and biodegradable plastics). Its good hydrophilicity enables it to quickly absorb wound exudate. After absorbing the exudate, sodium alginate and calcium chloride crosslink to form a gel structure, further enhancing the exudate absorption capacity, maintaining a moist wound environment, and promoting wound healing.

[0020] 2. Antibacterial property: The strong oxidizing property of the oxygen releasing agent can achieve excellent antibacterial effects, solve the problem of traditional antibiotic resistance, and at the same time, the released oxygen has certain anti-inflammatory ability.

[0021] 3. Good biocompatibility and biodegradability: The polymer electrospun substrate used is a biodegradable material, and its degradation products are non-toxic and harmless to organisms.

[0022] 4. It has the property of fiber membrane drying and can be stored for a long time. At the same time, after absorbing wound exudate, the hydrogel formed by sodium alginate and calcium chloride can absorb exudate and relieve pain.

[0023] The present invention also provides a preparation method of the multifunctional wound dressing described in the above technical solution. The method of the present invention is simple to operate and suitable for industrial production. Description of the Drawings

[0024] Figure 1 It is the infrared spectrum diagram of the wound dressings prepared in Example 1 and Comparative Examples 1-3;

[0025] Figure 2 It is the swelling and water absorption rate curve of the wound dressings prepared in Comparative Examples 1 and 2;

[0026] Figure 3 It is the physical size diagram of the wounds of non-infected bacteria, wounds infected with Staphylococcus aureus, wounds of commercially available wound dressings treating Staphylococcus aureus-infected wounds, and B / GA / SA / DA / Na treating Staphylococcus aureus-infected wounds;

[0027] Figure 4 It is the antibacterial zone diagram of the wound dressings in Example 1 and Comparative Examples 1-3;

[0028] Figure 5 It is the hydrophilic contact angle test diagram of the wound dressings obtained in Examples 1-2 and Comparative Example 2;

[0029] Figure 6 It is the change diagram of the hydrophilicity of PBAT, the wound dressings in Example 1 and Comparative Examples 1-3;

[0030] Figure 7 It is the bar chart of the contact angle degrees after 10 s of hydrophilicity test;

[0031] Figure 8 Oxygen release curves of the wound dressings prepared in Examples 1 and 3;

[0032] Figure 9 Test charts of the antibacterial effects of the wound dressings in Example 1 and Comparative Examples 1 to 3. Detailed implementation manners

[0033] The present invention provides a multifunctional wound dressing prepared by electrospinning a spinning solution, and the spinning solution comprises components with the following concentrations: 0.1-2.0 g / mL of a PLGA-PEG-PLGA triblock polymer, 0.2-3.0 g / mL of a biodegradable plastic, 0.1-6 wt% of calcium chloride, 0.1-6 wt% of sodium alginate, 0.01-4 wt% of dopamine hydrochloride, and 0.1-12 wt% of an oxygen releasing agent.

[0034] In the spinning solution of the present invention, the concentration of the PLGA-PEG-PLGA triblock polymer can specifically be 0.1, 0.25, 0.3, 0.4, 0.5, 1.0, 1.5 or 2.0 g / mL. The PLGA-PEG-PLGA triblock polymer is the substrate for electrospinning, and after adding sodium alginate and calcium chloride, inorganic ions will further induce crosslinking of the PLGA-PEG-PLGA triblock polymer.

[0035] In the present invention, the average molecular weight of the PLGA-PEG-PLGA triblock polymer is preferably 9000 g / mol.

[0036] In the present invention, the PLGA-PEG-PLGA triblock polymer is preferably a commercially available product or prepared by a method well-known to those skilled in the art, and more preferably prepared by a method comprising the following steps:

[0037] (1) Using high molecular weight polyethylene glycol (PEG) to initiate the polymerization of glycolide and lactide under the condition of stannous octoate (Sn(Oct) 2 ) as a catalyst;

[0038] (2) Precipitating the obtained polymerization product with ether, and then drying it in a vacuum oven to obtain the PLGA-PEG-PLGA triblock copolymer.

[0039] In the present invention, the molar ratio of polyethylene glycol, glycolide and lactide is preferably 1:50-1000:500-3000.

[0040] In the present invention, the molar ratio of polyethylene glycol to stannous octoate is preferably 1:0.001-0.1.

[0041] In the present invention, the number-average molecular weight of the polyethylene glycol is preferably 800 to 4000, and specifically may be 800, 2000 or 4000.

[0042] In the present invention, the temperature of the polymerization reaction is preferably 110 to 130 °C, specifically may be 110, 120 or 130 °C, and the time is preferably 12 to 28 h, specifically may be 12, 14, 18, 20, 24 or 28 h.

[0043] The concentration of the biodegradable plastic in the spinning solution of the present invention may specifically be 0.2, 0.5, 0.75, 1, 1.5, 2.0 or 3.0 g / mL.

[0044] In the present invention, the biodegradable plastic preferably includes one or more of a copolymer of butylene adipate and butylene terephthalate (PBAT), polycaprolactone and poly(butylene succinate / butylene terephthalate) (PBS); the biodegradable plastic has biodegradable properties and flexibility, and is easy to spin and form films.

[0045] In the present invention, both the biodegradable plastic and the PLGA-PEG-PLGA triblock polymer have good biocompatibility, and the PLGA-PEG-PLGA triblock polymer is the main material of the human suture approved by the FDA, and the degradation products are non-toxic.

[0046] The concentration of calcium chloride in the spinning solution of the present invention may specifically be 0.1, 0.5, 1, 2, 3, 4, 5 or 6 wt%.

[0047] The concentration of sodium alginate in the spinning solution of the present invention may specifically be 0.1, 0.5, 1, 2, 3, 4, 5 or 6 wt%.

[0048] In the present invention, the calcium chloride and sodium alginate can improve the ability to absorb exudate. At the same time, after absorbing the exudate, the two crosslink to form a gel structure, which can effectively maintain a moist wound environment.

[0049] The concentration of dopamine hydrochloride in the spinning solution of the present invention may specifically be 0.01, 0.1, 1, 2, 3 or 4 wt%, and the dopamine hydrochloride can improve hydrophilicity.

[0050] The concentration of the oxygen releasing agent in the spinning solution of the present invention may specifically be 0.1, 2, 4, 6, 8, 10 or 12 wt%; the oxygen releasing agent achieves an antibacterial effect by releasing oxygen, solves the problem of traditional antibiotic resistance, and at the same time endows the multifunctional wound dressing with certain anti-inflammatory ability.

[0051] In the present invention, the oxygen releasing agent preferably comprises a peroxide and / or a percarbonate. The peroxide preferably comprises one or more of sodium peroxide, lithium peroxide, potassium peroxide, calcium peroxide, magnesium peroxide and barium peroxide; the percarbonate preferably comprises sodium percarbonate and / or potassium percarbonate.

[0052] In the present invention, the spinning solution preferably further contains a solvent, and the solvent preferably comprises chloroform.

[0053] In a specific embodiment of the present invention, the spinning solution preferably comprises components with the following concentrations: PLGA-PEG-PLGA triblock polymer 0.25 g / mL, biodegradable plastic 0.5 g / mL, calcium chloride 4 wt%, sodium alginate 4 wt%, dopamine hydrochloride 2-4 wt% and oxygen releasing agent 4-6 wt%. In a specific embodiment of the present invention, the spinning solution preferably comprises components with the following concentrations: PLGA-PEG-PLGA triblock polymer 0.25 g / mL, biodegradable plastic 0.5 g / mL, calcium chloride 4 wt%, sodium alginate 4 wt%, dopamine hydrochloride 4 wt% and oxygen releasing agent 6 wt% or comprises components with the following concentrations: PLGA-PEG-PLGA triblock polymer 0.25 g / mL, biodegradable plastic 0.5 g / mL, calcium chloride 4 wt%, sodium alginate 4 wt%, dopamine hydrochloride 2 wt% and oxygen releasing agent 6 wt% or comprises components with the following concentrations: PLGA-PEG-PLGA triblock polymer 0.25 g / mL, biodegradable plastic 0.5 g / mL, calcium chloride 4 wt%, sodium alginate 4 wt%, dopamine hydrochloride 4 wt% and oxygen releasing agent 4 wt%.

[0054] The present invention also provides a preparation method of the multifunctional wound dressing described in the above technical solution. The spinning solution is subjected to electrospinning to obtain the multifunctional wound dressing.

[0055] In the present invention, the PLGA-PEG-PLGA triblock polymer, biodegradable plastic, calcium chloride, sodium alginate, dopamine hydrochloride, oxygen releasing agent and solvent are preferably mixed to obtain the spinning solution. The present invention has no special limitation on the specific manner of the mixing, and any manner well known to those skilled in the art can be adopted. In a specific embodiment of the present invention, it is preferred to first dissolve the PLGA-PEG-PLGA triblock polymer and biodegradable plastic in the solvent, and then add sodium alginate, calcium chloride, dopamine hydrochloride and oxygen releasing agent thereto and mix well to obtain the spinning solution.

[0056] In the present invention, the voltage of the electrospinning is preferably 10 to 14 kV, specifically it can be 10, 11, 12 or 14 kV, and the feeding speed is preferably 0.001 to 0.04 mm / s, specifically it can be 0.001, 0.005, 0.01, 0.02 or 0.04 mm / s.

[0057] The present invention also provides the application of the multifunctional wound dressing described in the above technical solution or the multifunctional wound dressing prepared by the preparation method described in the above technical solution in the preparation of skin wound dressings.

[0058] The present invention has no special limitation on the specific manner of the application, and the manner well-known to those skilled in the art can be adopted.

[0059] Next, the technical solutions in the present invention will be clearly and completely described in conjunction with the embodiments in the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present invention without making creative efforts belong to the protection scope of the present invention.

[0060] Types of raw materials:

[0061] Polyethylene glycol (PEG), glycolide (GA), lactide (LA), stannous octoate (Sn(Oct) 2 ), calcium chloride (CaCl 2 ), sodium alginate, dopamine hydrochloride, sodium peroxide, deionized water (H 2 O), chloroform, ether, toluene.

[0062] Sources of raw materials:

[0063] Polyethylene glycol, tannic acid, stannous octoate, calcium chloride, sodium alginate, dopamine hydrochloride, sodium peroxide are from Aladdin Reagent Company.

[0064] Preparation methods of PLGA-PEG-PLGA triblock copolymers in the examples and comparative examples:

[0065] Mix polyethylene glycol-2000, stannous octoate, glycolide and lactide for polymerization to obtain a polymerization product. The obtained polymerization product is precipitated with ether and then dried in a vacuum oven to obtain a PLGA-PEG-PLGA triblock copolymer, wherein the molar ratio of polyethylene glycol-2000, glycolide and lactide is 1:50:500, the molar ratio of polyethylene glycol to stannous octoate is 1:0.001, the temperature of the polymerization reaction is 110 °C, and the time is 28 h.

[0066] The average molecular weight of the obtained PLGA-PEG-PLGA triblock copolymer is 9000 g / mol.

[0067] Example 1

[0068] Preparation of a multifunctional wound dressing

[0069] Dissolve PBAT and PLGA-PEG-PLGA triblock copolymer in chloroform, then add sodium alginate, calcium chloride, dopamine hydrochloride and sodium peroxide, and mix well to make the inorganic substances disperse evenly, obtaining a spinning solution. The spinning solution includes the following components in concentration: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of PBAT, 4 wt% of calcium chloride, 4 wt% of sodium alginate, 4 wt% of dopamine hydrochloride and 6 wt% of sodium peroxide.

[0070] Perform electrospinning on the obtained spinning solution under the conditions of a voltage of 12 kV and a feeding speed of 0.005 mm / s to obtain the multifunctional wound dressing, denoted as B / GA / SA / DA / Na.

[0071] Comparative Example 1

[0072] Preparation of B / GA

[0073] Dissolve PBAT and PLGA-PEG-PLGA triblock copolymer in chloroform to obtain a spinning solution. The spinning solution includes the following components in concentration: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of PBAT.

[0074] Perform electrospinning on the obtained spinning solution under the conditions of a voltage of 12 kV and a feeding speed of 0.005 mm / s to obtain the multifunctional wound dressing, denoted as B / GA.

[0075] Comparative Example 2

[0076] Preparation of B / GA / SA

[0077] Dissolve PBAT and PLGA-PEG-PLGA triblock copolymer in chloroform, then add sodium alginate and calcium chloride, and mix well to make the inorganic substances disperse evenly, obtaining a spinning solution. The spinning solution includes the following components in concentration: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of PBAT, 4 wt% of calcium chloride, 4 wt% of sodium alginate.

[0078] Perform electrospinning on the obtained spinning solution under the conditions of a voltage of 12 kV and a feeding speed of 0.005 mm / s to obtain the multifunctional wound dressing, denoted as B / GA / SA.

[0079] Comparative Example 3

[0080] Preparation of B / GA / SA / DA

[0081] Dissolve PBAT and PLGA-PEG-PLGA triblock copolymer in chloroform, then add sodium alginate, calcium chloride, and dopamine hydrochloride, and mix well to evenly disperse the inorganic substances to obtain a spinning solution. The spinning solution includes components with the following concentrations: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of PBAT, 4 wt% of calcium chloride, 4 wt% of sodium alginate, and 4 wt% of dopamine hydrochloride.

[0082] Perform spinning on the obtained spinning solution under the conditions of a voltage of 12 kV and a feeding speed of 0.005 mm / s to obtain the multifunctional wound dressing, denoted as B / GA / SA / DA.

[0083] Figure 1 For the infrared spectra of the wound dressings prepared in Example 1 and Comparative Examples 1 to 3, it can be seen that the hydroxyl peak in B / GA / SA / DA / Na weakens, indicating that the inorganic ions have successfully promoted the crosslinking of the PLGA-PEG-PLGA triblock copolymer.

[0084] Figure 2 For the swelling and water absorption curves of the wound dressings prepared in Comparative Examples 1 and 2, it can be seen that compared with Comparative Example 1, the addition of calcium chloride and sodium alginate promotes the formation of hydrogel and can significantly improve the swelling and water absorption rate.

[0085] Promote wound healing ability:

[0086] Establish a wound model on the back of rats. The four wounds are a non-infected wound, a wound infected with Staphylococcus aureus, a wound infected with Staphylococcus aureus treated with a commercially available wound dressing, and a wound infected with Staphylococcus aureus treated with B / GA / SA / DA / Na prepared in Example 1. Take pictures at different days to record the wound size. The results are as Figure 3 shown. It can be intuitively seen that at the same time point, the wound area treated in Example 1 is smaller than that of other wound models.

[0087] Antibacterial ability:

[0088] Conduct an antibacterial zone experiment, and select Staphylococcus aureus and Escherichia coli for the experiment. Figure 4 For the results of the antibacterial zone experiment, Figure 4 In different antibacterial photos, the antibacterial zone in the upper left is the antibacterial effect of the wound dressing prepared in Comparative Example 1, the antibacterial zone in the upper right is the antibacterial effect of the wound dressing prepared in Comparative Example 2, the antibacterial zone in the lower left is the antibacterial effect of the wound dressing prepared in Comparative Example 3, and the antibacterial zone in the lower right is the antibacterial effect of the wound dressing prepared in Example 1. It can be seen that obvious antibacterial zones appear in B / GA / SA / DA / Na, indicating that the multifunctional wound dressing of the present invention can effectively inhibit bacterial growth.

[0089] Example 2

[0090] Same as Example 1, except that:

[0091] The spinning solution comprises components with the following concentrations: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of PBAT, 4 wt% of calcium chloride, 4 wt% of sodium alginate, 2 wt% of dopamine hydrochloride, and 6 wt% of oxygen releasing agent.

[0092] The hydrophilicity (10 s) of the wound dressings obtained in Examples 1-2 and Comparative Example 2 was tested, as Figure 5 shown. It can be seen that after the dopamine content is reduced, the improvement effect of hydrophilicity is small and the water absorption rate decreases significantly.

[0093] Figure 6 is a graph showing the change of hydrophilicity of PBAT, the wound dressings of Example 1 and Comparative Examples 1-3, Figure 7 is a bar graph of the contact angle degrees after 10 s of hydrophilicity test. It can be seen that the wound dressing prepared after adding 4 wt% dopamine absorbs water rapidly and the hydrophilic angle quickly changes to zero.

[0094] Example 3

[0095] Same as Example 1, except that:

[0096] The spinning solution comprises components with the following concentrations: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of PBAT, 4 wt% of calcium chloride, 4 wt% of sodium alginate, 4 wt% of dopamine hydrochloride, and 4 wt% of sodium peroxide.

[0097] The oxygen release amount of the wound dressings prepared in Examples 1 and 3 was tested, and the results are as Figure 8 shown. It can be seen that after the sodium peroxide content is reduced, the oxygen release amount decreases.

[0098] The antibacterial effects of the wound dressings of Examples 1 and Comparative Examples 1-3 were tested by using the method of bacterial live-dead staining, and the results are as Figure 9 , where the green fluorescence is for living bacteria and the red fluorescence is for dead bacteria, Figure 9 and the scale bar in each is 20 μm. It can be seen that a large amount of red fluorescence appears in the bacteria cultured with B / GA / SA / DA / Na, indicating that the dressing has good antibacterial performance.

[0099] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A multifunctional wound dressing, characterized in that: The spinning solution is prepared by electrostatic spinning. The spinning solution comprises the following components in concentrations: 0.1-2.0 g / mL of PLGA-PEG-PLGA triblock polymer, 0.2-3.0 g / mL of biodegradable plastic, 0.1-6 wt% of calcium chloride, 0.1-6 wt% of sodium alginate, 0.01-4 wt% of dopamine hydrochloride and 0.1-12 wt% of oxygen release agent.

2. The multifunctional wound dressing according to claim 1, characterized in that: The spinning solution comprises the following components in concentrations: 0.25 g / mL of PLGA-PEG-PLGA triblock polymer, 0.5 g / mL of biodegradable plastic, 4 wt% of calcium chloride, 4 wt% of sodium alginate, 2-4 wt% of dopamine hydrochloride and 4-6 wt% of oxygen release agent.

3. The multifunctional wound dressing according to claim 1 or 2, characterized in that: The biodegradable plastic includes one or more of a copolymer of butylene adipate and butylene terephthalate, polycaprolactone and polybutylene succinate / terephthalate.

4. The multifunctional wound dressing according to claim 1 or 2, characterized in that: The oxygen-releasing agent includes peroxide and / or percarbonate.

5. The multifunctional wound dressing according to claim 4, characterized in that: The peroxide includes one or more of sodium peroxide, lithium peroxide, potassium peroxide, calcium peroxide, magnesium peroxide and barium peroxide; the percarbonate includes sodium percarbonate and / or potassium percarbonate.

6. The multifunctional wound dressing according to claim 1, characterized in that: The spinning solution further contains a solvent, which includes chloroform.

7. The multifunctional wound dressing according to claim 1, characterized in that: The average molecular weight of the PLGA-PEG-PLGA triblock polymer is 9000 g / mol.

8. The method for preparing the multifunctional wound dressing according to any one of claims 1 to 7, characterized in that: The spinning solution is subjected to electrostatic spinning to obtain the multifunctional wound dressing.

9. The preparation method according to claim 8, characterized in that: The voltage of the electrostatic spinning is 10-14 kV, and the pushing speed is 0.001-0.04 mm / s.

10. Use of the multifunctional wound dressing according to any one of claims 1 to 7 or the multifunctional wound dressing prepared by the preparation method according to claim 8 or 9 in preparing skin wound dressing.

Images