Application and device of efficient metal organic catalyst in natural product synthesis
By designing a highly efficient metal organic catalyst composed of metal center, nitrogen-containing ligand and functional auxiliary ligand, the problems of low catalytic reaction efficiency and ease of inactivation in the synthesis of natural products are solved, and efficient catalytic, long life and renewable effects are achieved.
Patent Information
- Application Number
- CN202510205064.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-24
- Publication Date
- 2025-05-30
AI Technical Summary
The existing metal organic catalysts have low catalytic reaction efficiency, easy deactivation, and low reaction efficiency in the synthesis of natural products, and there is room for improvement in catalyst dispersion, reaction condition control and recycling.
A high-efficiency metal organic catalyst is designed, consisting of metal centers such as platinum and palladium, nitrogen-containing ligands such as pyridine and imidazole, and auxiliary ligands with functional groups such as alcohol groups and ketone groups. Through synergistic effects, the electron density of the metal center is adjusted, the catalytic activity and selectivity is optimized, and the service life of the catalyst is extended through self-healing chemical groups.
It significantly improves the efficiency and selectivity of the catalytic reaction, extends the service life of the catalyst, enhances the mechanical strength and chemical stability of the catalyst, and realizes efficient recovery and recycling of the catalyst.
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Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of natural product synthesis, and particularly relates to the application and device of an efficient metal-organic catalyst in natural product synthesis. Background Art
[0002] With the continuous development of chemical synthesis technology, the synthesis of natural products plays a crucial role in the fields of pharmaceuticals, agriculture, food, and others. In the synthesis of natural products, catalytic reactions are widely used in the synthesis of various target compounds. Metal-organic catalysts have become a current research hotspot due to their excellent catalytic activity, selectivity, and controllability.
[0003] However, in the catalytic reactions of natural product synthesis, most traditional metal-organic catalysts rely on the interaction between the metal center and the ligand. However, due to the poor activity, stability, and reusability of metal-organic catalysts during the catalytic process, they are usually limited. In the prior art, although there have been some efficient catalyst designs, there are still problems such as insufficient catalytic activity, easy deactivation of the catalyst, and low reaction efficiency. The catalytic activity and selectivity of many metal-organic catalysts will decline during long-term use, and some metal-organic catalysts may become deactivated under relatively mild conditions, during long-term reactions, or in complex reaction systems. At the same time, there is also room for improvement in the existing catalytic reaction devices in terms of catalyst dispersion, precise control of reaction conditions, and recovery and recycling of catalysts.
[0004] Therefore, it is necessary to propose the application and device of an efficient metal-organic catalyst in natural product synthesis to solve the problem of low catalytic reaction efficiency of metal-organic catalysts in the prior art.
[0005] The above information disclosed in this background art is only used to increase the understanding of the background art of the present invention. Therefore, it may include prior art that is not known to those of ordinary skill in the art. Summary of the Invention
[0006] The purpose of the present invention is to provide the application and device of an efficient metal-organic catalyst in natural product synthesis to solve the problems raised in the above background art.
[0007] To achieve the above purpose, the present invention provides the following technical solutions:
[0008] An efficient metal-organic catalyst, wherein the metal-organic catalyst is composed of a metal center, a nitrogen-containing ligand, and a functional auxiliary ligand. The metal center is at least one of platinum, palladium, copper, cobalt, manganese, zinc, molybdenum, and rhodium. The nitrogen-containing ligand is a pyridine, imidazole, or thiazole ligand. The functional auxiliary ligand is an organic molecule with an alcohol group, a ketone group, an amino group, a phosphoric acid group, or a thiol functional group.
[0009] Preferably, the synergistic effect between the metal center and the nitrogen-containing ligand regulates the electron density of the metal center through the hole effect or the coordination enhancement effect, optimizing the catalytic activity and selectivity during the reaction process;
[0010] Introduce a coordination enhancement effect model, calculate the change in electron density between the metal center and the nitrogen-containing ligand, and optimize its catalytic effect;
[0011] ΔE = E q -E j -E p
[0012] In the formula, ΔE is the energy change due to ligand synergy, E q is the total energy of the metal center-nitrogen-containing ligand complex, E j is the total energy of the metal center, E p is the total energy of the nitrogen-containing ligand;
[0013] And by embedding chemical groups with self-healing properties into the metal-organic catalyst, self-healing during its long-term use is achieved. The metal-organic catalyst is combined with other functional materials (such as conductive polymers, nanocarbon materials, silicon materials, etc.), and the catalytic reaction is optimized through synergistic effects. The composite material can provide more active sites in heterogeneous catalytic reactions and enhance the mechanical strength and chemical stability of the catalyst.
[0014] Preferably, the following strategies can be adopted to prepare the metal-organic catalyst:
[0015] (1) Introduce unsaturated ligand sites of the metal center to make the metal center catalytically active, which can be synthesized by hydrothermal and microwave-assisted methods;
[0016] (2) Use the metal center as a carrier to load a ligand structure with catalytic activity, which can be synthesized by direct synthesis or post-synthesis modification methods;
[0017] (3) Utilize the pores or surface of the metal center to load the ligand structure with catalytic activity, which can be synthesized by impregnation, sedimentation or adsorption methods.
[0018] A catalytic reaction method for natural product synthesis, using the high-efficiency metal-organic catalyst described in any one of the above, synthesizes target natural products through catalytic cross-coupling reactions, redox reactions or cyclization reactions, and the natural products are polyphenolic compounds, flavonoid compounds, terpene compounds, quinone compounds or alkaloid compounds.
[0019] Preferably, the catalytic reaction is carried out under mild reaction conditions, with the temperature range being from 20°C to 150°C, the reaction solvent being a polar solvent, a non-polar solvent or a two-phase solvent system, and the usage amount of the metal-organic catalyst being 0.1% to 10% of the molar ratio of the target natural product.
[0020] Preferably, the metal-organic catalyst realizes carbon-carbon bond formation reaction in the cross-coupling reaction, promotes the breaking and recombination of chemical bonds in the redox reaction, guides the cyclization reaction to occur along a specific path in the cyclization reaction, and optimizes the dispersibility and catalytic efficiency of the metal-organic catalyst in the heterogeneous system through surface modification and nanostructure design.
[0021] Introduce the reaction kinetic model, calculate the reaction rate under different catalytic conditions, and optimize the efficiency and selectivity of the catalytic reaction;
[0022]
[0023] In the formula, k is the reaction rate constant, A is the frequency factor, E a is the reaction activation energy, R is the gas constant, and T is the absolute temperature;
[0024] Modify the surface of the catalyst to make it have good hydrophilicity or hydrophobicity. This adjustment can make the catalyst show better dispersibility and catalytic effect in different solvent systems, especially improving the catalytic efficiency in heterogeneous reactions.
[0025] A catalytic reaction device for the synthesis of natural products, the device includes a reaction kettle, a temperature control system, a catalyst addition device, a gas delivery device and a collection device, the catalyst is the high-efficiency metal-organic catalyst described in any one of the above, and the catalytic reaction is carried out under precisely controlled reaction conditions.
[0026] Preferably, the reaction kettle is made of a material resistant to high temperature and high pressure, is equipped with a stirring device, and promotes the efficient dispersion of the metal-organic catalyst and the optimization of the reaction process by adjusting the amount of dissolved gas in the reaction solvent and the reaction atmosphere. The temperature control system introduces an adaptive control mechanism based on the change of reaction temperature to optimize the reaction rate and selectivity and reduce energy consumption.
[0027] Preferably, the catalyst addition device introduces an intelligent catalyst adjustment system. By embedding sensors and real-time data monitoring devices, it can feedback and adjust the addition amount of the metal-organic catalyst in real time, and introduce supercritical fluid extraction or magnetic recovery technology to realize the real-time recovery and recycling of the metal-organic catalyst.
[0028] Compared with the prior art, the beneficial effects of the present invention are:
[0029] The metal-organic catalyst of the present invention significantly improves the efficiency of catalytic reactions through the elaborate design of the metal center, nitrogen-containing ligand, and functional auxiliary ligand. Among them, the synergistic effect between the metal center and the nitrogen-containing ligand regulates the electron density of the metal, optimizes the catalytic activity and selectivity, and at the same time, the chemical group with self-healing properties enables the catalyst to maintain high efficiency during long-term use; the high-efficiency loading and dispersion of the metal-organic catalyst are achieved through different synthesis methods, thereby enhancing the catalytic effect, and its ability to adapt to the synthesis of a variety of natural products makes it widely applicable in different fields. In addition, the precise control and intelligent catalyst adjustment system in the catalytic reaction device improve the utilization efficiency of the catalyst, avoid the overuse of the catalyst and realize its recycling, so as to achieve higher reaction efficiency and lower cost in the synthesis of natural products. Detailed implementation manners
[0030] The following will clearly and completely describe the technical solutions in the inventive content of the present invention in combination with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.
[0031] Example 1:
[0032] A highly efficient metal-organic catalyst is composed of a metal center, a nitrogen-containing ligand, and a functional auxiliary ligand. Among them, the metal center is at least one of platinum, palladium, copper, cobalt, manganese, zinc, molybdenum, and rhodium, the nitrogen-containing ligand is a pyridine, imidazole, or thiazole ligand, and the functional auxiliary ligand is an organic molecule with functional groups such as alcohol groups, ketone groups, amino groups, phosphate groups, or thiol groups, which can significantly improve the catalytic efficiency, selectivity, and stability in the synthesis of natural products.
[0033] The synergistic effect between the metal center and the nitrogen-containing ligand regulates the electron density of the metal center through the hole effect or coordination enhancement effect, and optimizes the catalytic activity and selectivity during the reaction process; the coordination enhancement effect model is introduced to calculate the electron density changes of the metal center and the nitrogen-containing ligand, and optimize its catalytic effect;
[0034] And by embedding chemical groups with self-healing properties into the metal-organic catalyst, self-healing during long-term use is realized. The use of green solvents (such as ionic liquids, supercritical carbon dioxide, etc.) or a completely solvent-free reaction system reduces the use of harmful solvents and improves the environmental friendliness of catalytic reactions. This can further enhance the sustainability of this technology.
[0035] Furthermore, this metal-organic catalyst can significantly improve the reaction efficiency in the catalytic reaction and selectively promote the formation of target natural products. By introducing chemical groups with self-healing properties, the metal-organic catalyst can automatically repair during long-term use, extending its service life and avoiding the problem of performance degradation during the use of traditional catalysts.
[0036] The following strategies can be adopted to prepare the metal-organic catalyst:
[0037] (1) Introduce unsaturated coordination sites in the metal center to endow the metal center with catalytic activity, which can be synthesized by hydrothermal and microwave-assisted methods;
[0038] (2) Use the metal center as a carrier to load a ligand structure with catalytic activity, which can be synthesized by direct synthesis or post-synthesis modification methods;
[0039] (3) Load a ligand structure with catalytic activity using the pores or surface of the metal center, which can be synthesized by impregnation, precipitation or adsorption methods.
[0040] Furthermore, multiple strategies such as hydrothermal and microwave-assisted synthesis, direct synthesis and post-modification, impregnation, and precipitation are adopted in the preparation method, enabling the metal-organic catalyst to maintain good dispersion during the reaction process and enhancing the catalytic efficiency.
[0041] A catalytic reaction method for natural product synthesis uses the highly efficient metal-organic catalyst of any one of the above to synthesize target natural products through catalytic cross-coupling reactions, redox reactions or cyclization reactions. The natural products are polyphenolic compounds, flavonoid compounds, terpene compounds, quinone compounds or alkaloid compounds.
[0042] The catalytic reaction is carried out under mild reaction conditions, with the temperature range from 20°C to 150°C, the reaction solvent being a polar solvent, a non-polar solvent or a two-phase solvent system, and the usage amount of the metal-organic catalyst being 0.1% to 10% of the molar ratio of the target natural product.
[0043] Furthermore, the catalytic reaction can be carried out under mild reaction conditions, with the temperature range from 20°C to 150°C, applicable to a variety of complex reaction systems, and the amount of the metal-organic catalyst used being low (0.1% to 10%), reducing costs and having high raw material utilization and environmental protection advantages.
[0044] Metal-organic catalysts achieve carbon-carbon bond formation reactions in cross-coupling reactions, promote the cleavage and recombination of chemical bonds in redox reactions, guide cyclization reactions to occur along a specific path in cyclization reactions, and exhibit good catalytic activity and high selectivity in these reactions. Moreover, through surface modification and nanostructure design, the dispersibility and catalytic efficiency of metal-organic catalysts in heterogeneous systems are optimized.
[0045] A reaction kinetics model is introduced to calculate the reaction rates under different catalytic conditions and optimize the efficiency and selectivity of catalytic reactions. By surface-modifying the metal-organic catalyst and adding functional groups with electronic effects (such as fluorine groups, sulfonic acid groups, etc.), the electronic properties of the catalyst are further adjusted and the catalytic activity is enhanced. This modification can also improve the anti-toxicity of the catalyst and enhance its stability.
[0046] A catalytic reaction device for natural product synthesis includes a reaction kettle, a temperature control system, a catalyst addition device, a gas delivery device, and a collection device. The catalyst is the highly efficient metal-organic catalyst described in any of the above, and the catalytic reaction is carried out under precisely controlled reaction conditions.
[0047] The reaction kettle is made of materials resistant to high temperature and high pressure, equipped with a stirring device, and by adjusting the amount of dissolved gas in the reaction solvent and the reaction atmosphere, the efficient dispersion of the metal-organic catalyst and the optimization of the reaction process are promoted. The temperature control system introduces an adaptive control mechanism based on the change of reaction temperature to optimize the reaction rate and selectivity and reduce energy consumption.
[0048] The catalyst addition device introduces an intelligent catalyst regulation system. By embedding sensors and real-time data monitoring devices, the addition amount of the metal-organic catalyst can be real-time feedback and adjusted, and supercritical fluid extraction or magnetic recovery technology is introduced to achieve the real-time recovery and recycling of the metal-organic catalyst.
[0049] Furthermore, the catalytic reaction device is equipped with a highly efficient stirring device and an intelligent catalyst regulation system, which can accurately control the amount of dissolved gas and the addition amount of the catalyst during the reaction process, thereby optimizing the dispersibility and reaction efficiency of the catalyst. In addition, the intelligent catalyst regulation system can also monitor the usage of the catalyst in real time, providing the possibility for the recycling of the catalyst, reducing the waste of the catalyst, and lowering the reaction cost.
[0050] As described above, through the elaborate design of the metal center, nitrogen-containing ligand, and functional auxiliary ligand in the metal-organic catalyst of the present invention, the efficiency of the catalytic reaction is significantly improved. The synergistic effect between the metal center and the nitrogen-containing ligand regulates the electron density of the metal, optimizing the catalytic activity and selectivity. Meanwhile, the chemical group with self-repair properties enables the catalyst to maintain high efficiency during long-term use. The efficient loading and dispersion of the metal-organic catalyst are achieved through different synthesis methods, thereby enhancing the catalytic effect. The ability to adapt to the synthesis of various natural products enables it to have a wide range of applications in different fields. In addition, the precise control and intelligent catalyst adjustment system in the catalytic reaction device improve the utilization efficiency of the catalyst, avoid the overuse of the catalyst, and enable its recycling and reuse, thus achieving higher reaction efficiency and lower costs in the synthesis of natural products.
[0051] Example 2:
[0052] Application Example: Combinations of Different Metal-Organic Catalyst Structures and Their Applications in the Synthesis of Natural Products
[0053] 1. Combinations of the Synergistic Effects of Metal Centers and Nitrogen-Containing Ligands
[0054] Metal Centers: Platinum (Pt), Palladium (Pd), Copper (Cu).
[0055] Nitrogen-Containing Ligand: Pyridine.
[0056] Functional Auxiliary Ligand: Organic Molecules with Amino (-NH 2 ) and Alcohol (-OH) Groups.
[0057] Application Example:
[0058] Natural Product: Flavonoids (such as Quercetin).
[0059] Catalytic Reaction: Cross-Coupling Reaction. This combination can significantly improve the efficiency of carbon-carbon bond formation through the synergistic effect between the platinum metal center and the pyridine ligand. The amino and alcohol functional group ligands enhance the affinity of the catalyst and optimize the selectivity of the catalytic reaction.
[0060] Reaction Conditions: Mild Conditions (temperature 30°C to 80°C), using polar solvents (such as ethanol), and the amount of metal-organic catalyst is 0.5% of the natural product.
[0061] 2. Combinations of the Synergistic Effects of Metal Centers and Imidazole Ligands
[0062] Metal Centers: Palladium (Pd), Cobalt (Co), Zinc (Zn).
[0063] Nitrogen-Containing Ligand: Imidazole.
[0064] Functional auxiliary ligand: an organic molecule with a phosphate group (-PO 4 ) and a thiol group (-SH).
[0065] Application examples:
[0066] Natural products: polyphenolic compounds (such as catechins).
[0067] Catalytic reaction: redox reaction. The electronic effect between the palladium metal and the imidazole ligand enhances the efficiency of the catalytic reaction, and the phosphate group and thiol group functional ligands contribute to improving the stability and catalytic efficiency of the catalyst in the catalytic reaction.
[0068] Reaction conditions: The temperature range is 50 °C to 100 °C, using a non-polar solvent (such as n-hexane) and a gas atmosphere (such as hydrogen), and the metal-organic catalyst dosage is 0.2% to 5%.
[0069] 3. Combination of the synergistic effect of the metal center and the thiazole ligand
[0070] Metal center: manganese (Mn), molybdenum (Mo), rhodium (Rh).
[0071] Nitrogen-containing ligand: thiazole.
[0072] Functional auxiliary ligand: an organic molecule with a keto group (-C=O) and an amino group (-NH 2 ) functional groups.
[0073] Application examples:
[0074] Natural products: alkaloid compounds (such as nicotine).
[0075] Catalytic reaction: cyclization reaction. This catalyst combination adjusts the electron density of the metal center through the synergistic effect of the metal center and the thiazole ligand, optimizes the activity of the catalyst and improves the selectivity of the catalytic reaction.
[0076] Reaction conditions: The temperature range is 100 °C to 150 °C, using a polar solvent (such as dimethyl sulfoxide, DMSO), and the metal-organic catalyst dosage is 1% of the target natural product.
[0077] 4. Enhanced effect combination of the metal center and the imidazole ligand
[0078] Metal center: molybdenum (Mo), copper (Cu).
[0079] Nitrogen-containing ligand: imidazole.
[0080] Functional auxiliary ligand: an organic molecule containing an alcohol group (-OH) and a thiol group (-SH) functional groups.
[0081] Application examples:
[0082] Natural products: Terpenoids (such as geraniol).
[0083] Catalytic reaction: Cross-coupling reaction. The coordination of copper and molybdenum metals through imidazole ligands improves the efficiency of the catalytic reaction, while the alcohol group and thiol group play important roles in the dispersion and stability of the metal-organic catalyst.
[0084] Reaction conditions: The temperature range is 60°C to 120°C, a polar solvent (such as an ethanol / water mixed solvent system) is used, and the amount of the metal-organic catalyst used is 0.5%.
[0085] 5. Combination of metal center, thiazole ligand and self-healing group
[0086] Metal center: Cobalt (Co), Platinum (Pt).
[0087] Nitrogen-containing ligand: Thiazole
[0088] Functional auxiliary ligand: Chemical groups with self-healing properties, such as keto group (-C=O) and amino group (-NH 2 )
[0089] Application examples:
[0090] Natural products: Quinone compounds (such as quinorubin).
[0091] Catalytic reaction: Redox reaction. The synergistic effect between cobalt and thiazole ligand enhances the catalytic activity, and the keto group and amino group with self-healing properties contribute to improving the stability and reusability of the catalyst in long-term reactions.
[0092] Reaction conditions: The temperature range is 40°C to 80°C, a two-phase solvent system (such as water / alcohol solvent) is used, and the catalyst dosage is 1% of the target product.
[0093] Application effects:
[0094] These combinations of metal-organic catalysts have demonstrated excellent catalytic performance in the synthesis of natural products, especially in terms of improving reaction efficiency, enhancing selectivity and self-healing properties. These catalysts show strong application potential in different reaction types (such as cross-coupling reaction, redox reaction, cyclization reaction) and can adapt to a variety of complex reaction systems, providing new technical approaches for the efficient synthesis of natural products.
[0095] Example 3:
[0096] An embodiment of the present invention further provides a readable storage medium, on which a program for implementing a catalytic reaction method for natural product synthesis is stored. When the program is executed by a processor, it implements each process of the above-mentioned catalytic reaction method embodiment and can achieve the same technical effects. To avoid repetition, it will not be elaborated here. Among them, the computer-readable storage medium includes, for example, a read-only memory (ROM), a random access memory (RAM), a magnetic disk, or an optical disc, etc.
[0097] In the description of this specification, the description with reference to terms such as "an embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.
[0098] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and deformations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A highly efficient metal organic catalyst, characterized in that: The metal organic catalyst is composed of a metal center, a nitrogen-containing ligand and a functional auxiliary ligand, wherein the metal center is at least one of platinum, palladium, copper, cobalt, manganese, zinc, molybdenum and rhodium, the nitrogen-containing ligand is a pyridine, imidazole or thiazole ligand, and the functional auxiliary ligand is an organic molecule with an alcohol group, a keto group, an amino group, a phosphate group or a thiol functional group.
2. A highly efficient metal organic catalyst according to claim 1, characterized in that: The synergistic effect between the metal center and the nitrogen-containing ligand adjusts the electron density of the metal center through a hole effect or a coordination enhancement effect, thereby optimizing the catalytic activity and selectivity during the reaction; A coordination enhancement effect model is introduced to calculate the electron density change between the metal center and the nitrogen-containing ligand, and optimize the catalytic effect; ΔE=E q -E j -E p Where ΔE is the energy change due to the ligand synergy, E q is the total energy of the metal center-nitrogen-containing ligand complex, E j is the total energy of the metal center, E p is the total energy of the nitrogen-containing ligand; And by embedding chemical groups with self-repairing properties into the metal organic catalyst, its self-repairing during long-term use is achieved.
3. A highly efficient metal organic catalyst according to claim 2, characterized in that: The following strategies can be adopted to prepare the metal organic catalyst: (1) introducing an unsaturated coordination site to the metal center to make the metal center catalytically active, which can be synthesized by hydrothermal and microwave-assisted methods; (2) using the metal center as a carrier to load a ligand structure with catalytic activity, which can be achieved by direct synthesis or post-synthesis modification; (3) The ligand structure having catalytic activity is loaded on the pores or surface of the metal center, and can be synthesized by impregnation, precipitation or adsorption methods.
4. A catalytic reaction method for natural product synthesis, characterized in that: Using the efficient metal organic catalyst described in claim 1 or 2, the target natural product is synthesized by catalyzing cross-coupling reaction, redox reaction or cyclization reaction. The natural product is a polyphenol compound, a flavonoid compound, a terpene compound, a quinone compound or an alkaloid compound.
5. A catalytic reaction method for natural product synthesis according to claim 4, characterized in that: The catalytic reaction is carried out under mild reaction conditions, the temperature range is 20°C to 150°C, the reaction solvent is a polar solvent, a non-polar solvent or a two-phase solvent system, and the amount of the metal organic catalyst used is 0.1% to 10% of the molar ratio of the target natural product.
6. A catalytic reaction method for natural product synthesis according to claim 5, characterized in that: The metal organic catalyst realizes a carbon-carbon bond formation reaction in a cross-coupling reaction, promotes the breaking and recombination of chemical bonds in a redox reaction, and guides the cyclization reaction to occur along a specific path in a cyclization reaction; Introduce reaction kinetics models to calculate reaction rates under different catalytic conditions and optimize the efficiency and selectivity of catalytic reactions; Where k is the reaction rate constant, A is the frequency factor, and E a is the reaction activation energy, R is the gas constant, and T is the absolute temperature; Furthermore, the dispersibility and catalytic efficiency of the metal organic catalyst in a multiphase system are optimized through surface modification and nanostructure design.
7. A catalytic reaction device for natural product synthesis, characterized in that: The device includes a reaction kettle, a temperature control system, a catalyst adding device, a gas conveying device and a collecting device. The catalyst is a high-efficiency metal organic catalyst as described in claim 4 or 5, and the catalytic reaction is carried out under precisely controlled reaction conditions.
8. A catalytic reaction device for natural product synthesis according to claim 7, characterized in that: The reactor is made of high temperature and high pressure resistant materials and is equipped with a stirring device. By adjusting the amount of dissolved gas in the reaction solvent and the reaction atmosphere, the efficient dispersion of the metal organic catalyst and the optimization of the reaction process are promoted. The temperature control system introduces an adaptive control mechanism based on the change of reaction temperature to optimize the reaction rate and selectivity and reduce energy consumption.
9. A catalytic reaction device for natural product synthesis according to claim 8, characterized in that: The catalyst adding device introduces an intelligent catalyst regulating system, which can provide real-time feedback and adjust the addition amount of the metal organic catalyst by embedding sensors and real-time data monitoring equipment, and introduces supercritical fluid extraction or magnetic recovery technology to achieve real-time recovery and regeneration of the metal organic catalyst.