Allergen inhibitors and allergen inhibition products

Abstract

Provided are: an allergen inhibitor which exhibits an excellent allergen-inhibiting effect; and an allergen-inhibiting product which uses the allergen inhibitor. The allergen inhibitor according to the present invention comprises an allergen-inhibiting compound which has one or more acidic functional groups and in which the acidic functional groups are bonded to a nitrogen atom via one or more carbon atoms, thereby effectively inhibiting a reaction between an allergen and a specific antibody and exhibiting an excellent allergen-inhibiting effect. An allergen-inhibiting product comprising a substrate and an allergen inhibitor exhibits an excellent allergen-inhibiting effect.

Description

Technical Field

[0001] The present invention relates to an allergen inhibitor and an allergen-inhibiting product. Background Art

[0002] In recent years, various allergic diseases such as atopic dermatitis, bronchial asthma, and allergic rhinitis have become problems. As the main cause of these allergic diseases, allergens such as mites living in houses, especially allergens (Der1, Der2) of house dust mites abundantly present in indoor dust, and cedar pollen allergens (Cryj1, Cryj2) mainly floating in the air in large amounts in spring have increased in the living space.

[0003] The allergens of house dust mites are not the house dust mites themselves, but the corpses and feces of house dust mites become allergens. Therefore, even if the house dust mites are eradicated, the allergic diseases cannot be fundamentally solved.

[0004] In addition, Cryj1 and Cryj2, which are cedar pollen allergens, are glycoproteins with a molecular weight of about 40 kDa and about 37 kDa, respectively. When these cedar pollen allergens adhere to the nasal mucosa, etc., they are recognized as foreign substances outside the organism and cause an inflammatory reaction.

[0005] Therefore, a technology for removing allergens from the living space or denaturing allergens to inactivate them is needed.

[0006] Patent Document 1 discloses a cellulose-based fiber having an allergen treatment ability, which is characterized in that it supports an allergen treatment agent containing a nitrogen compound having a given chemical structural formula or a solvate thereof in an active ingredient.

[0007] Prior Art Documents

[0008] Patent Documents

[0009] Patent Document 1: Japanese Patent Application Laid-Open No. 2007-31889 Summary of the Invention

[0010] Technical Problem to be Solved by the Invention

[0011] However, the allergen treatment ability (allergen inhibition effect) of the allergen treatment agent disclosed in Patent Document 1 is insufficient, and an allergen inhibitor that exhibits an excellent allergen inhibition effect is desired.

[0012] The present invention provides an allergen inhibitor that exhibits an excellent allergen inhibition effect, and an allergen-inhibiting product obtained by treating the allergen inhibitor with an allergen target object.

[0013] Technical Means for Solving the Problem

[0014] The allergen inhibitor of the present invention contains an allergen-inhibiting compound having one or more acidic functional groups, and the acidic functional groups are bonded to a nitrogen atom through one or more carbon atoms.

[0015] The allergen-inhibiting product of the present invention includes a substrate and the allergen inhibitor contained in the substrate.

[0016] Advantages of the Invention

[0017] The allergen inhibitor of the present invention contains an allergen-inhibiting compound having one or more acidic functional groups, and the acidic functional groups are bonded to a nitrogen atom through one or more carbon atoms. Therefore, it can effectively inhibit the reaction between an allergen and a specific antibody (allergen-inhibiting effect). Detailed Embodiments

[0018] The allergen inhibitor of the present invention contains an allergen-inhibiting compound as an active ingredient, the allergen-inhibiting compound having one or more acidic functional groups, and the acidic functional groups are bonded to a nitrogen atom through one or more carbon atoms. It should be noted that the allergen-inhibiting compound can be used alone or in combination of two or more.

[0019] The content of the allergen-inhibiting compound in the allergen inhibitor is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and most preferably 100%.

[0020] The allergen inhibitor exerts an excellent allergen-inhibiting effect by containing an allergen-inhibiting compound having one or more acidic functional groups, and the acidic functional groups are bonded to a nitrogen atom through one or more carbon atoms.

[0021] Here, the allergen inhibitor refers to a substance having an allergen-inhibiting effect. The allergen-inhibiting effect can be judged, for example, by the following method. Dissolve the freeze-dried powder of the allergen in a phosphate buffer (pH 7.6) to prepare an allergen solution with a protein content of 20 μg / ml. It should be noted that, as the allergen, for example, an allergen commercially available from COSMO BIO Co., Ltd. under the trade name "Mite Extract-Df" can be used.

[0022] Dilute the allergen inhibitor with ion-exchanged water to prepare a 1% by mass dilution of the allergen inhibitor.

[0023] Next, prepare a test tube containing 1 ml of the allergen stock solution, add 100 μl of the allergen inhibitor dilution solution to the test tube, and shake it at 25°C for 16 hours to prepare a test solution.

[0024] Next, use a measurement reagent to measure the amount W of Derf1 present in the test solution in the test tube 1 (ng / ml). It should be noted that as the measurement reagent, for example, a measurement reagent commercially available from Nitchi Pharmaceutical Co., Ltd. of Japan under the trade name "ELISA Kit for Measuring Mite Allergen Derf1" can be used.

[0025] In addition, except for preparing the test solution without adding the allergen inhibitor solution to the test tube, the amount W of Derf1 present in the test solution in the test tube is measured in the same manner as described above 0 (ng / ml).

[0026] Then, calculate the allergen inhibition rate (%) based on the following formula. When the allergen inhibition rate is 60% or more, it can be judged that the allergen inhibition effect is present.

[0027] Allergen inhibition rate (%) = 100 - (W 1 / W 0 ) × 100

[0028] The allergen inhibition rate of the allergen inhibitor is preferably 70% or more, more preferably 80% or more, more preferably 90% or more, and more preferably 95% or more.

[0029] The content of the allergen inhibitory compound in the allergen inhibitor is preferably 80% by mass or more, more preferably 85% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass or more.

[0030] Regarding the number of acidic functional groups in the allergen inhibitory compound, from the viewpoint of improving the allergen inhibition effect of the allergen inhibitor, it is preferably 1 to 5, more preferably 3 to 5.

[0031] As the acidic functional group, it refers to a functional group that can release hydrogen ions (protons) in an aqueous solution. The acidic functional group is preferably an H-type acidic functional group. There is no particular limitation on the acidic functional group. For example, carboxyl (-COOH), sulfo group (sulfonic acid group) (-SO 3 H), phosphonic acid group [-P(=O)(OH) 2 , phosphate group [-OPO(OH) 2 , etc. can be mentioned. From the viewpoint that the allergen inhibitor has an excellent allergen inhibition effect, carboxyl, sulfo group, and phosphonic acid group are preferred, carboxyl and phosphonic acid group are more preferred, and carboxyl is more preferred.

[0032] In the allergen-inhibiting compound, the acidic functional group is bonded to the nitrogen atom via more than one carbon atom. It suffices that the acidic functional group is bonded to the nitrogen atom via more than one carbon atom, and the carbon atom may be either a carbon atom constituting a chain-like skeleton or a carbon atom constituting a cyclic skeleton. From the viewpoint of excellent allergen-inhibiting effect of the allergen inhibitor, it preferably contains a carbon atom constituting a chain-like skeleton, and more preferably is a carbon atom constituting a chain-like skeleton. As the cyclic skeleton, an alicyclic skeleton is preferred, and a cycloalkane skeleton is preferred. The chain-like skeleton also includes the case where the number of carbon atoms is one. As the cycloalkane skeleton, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, cyclononane, cyclodecane, norbornene, bicyclo[1.1.0]butane, bicyclo[1.1.1]pentane, bicyclo[2.1.0]pentane, bicyclo[2.1.1]hexane, bicyclo[3.1.0]hexane, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, adamantane, diamantane, decalin, etc. can be mentioned.

[0033] The content of the nitrogen atom in the allergen-inhibiting compound is preferably 5% or more, and more preferably 6% or more. The content of the nitrogen atom in the allergen-inhibiting compound is preferably 12% or less, and more preferably 11% or less. When the content of the nitrogen atom in the allergen-inhibiting compound is within the above range, the acidic functional group and the nitrogen atom in the allergen-inhibiting compound moderately interact within the molecule, and the allergen-inhibiting effect of the allergen inhibitor is improved.

[0034] It should be noted that the content (%) of the nitrogen atom in the allergen-inhibiting compound is a value calculated based on the following formula. In the case where the allergen-inhibiting compound forms a hydrate, the number of atoms of water (H 2 O) molecules is not included in the total atomic weight of all atoms constituting the allergen-inhibiting compound.

[0035] Content of nitrogen atom (%)

[0036] = 100 × (total atomic weight of all nitrogen atoms in the allergen-inhibiting compound)

[0037] / (total atomic weight of all atoms constituting the allergen-inhibiting compound)

[0038] Regarding the pH of a 0.5 mass% aqueous solution of the allergen-inhibiting compound at 25°C, from the viewpoint of easily maintaining the acidity of the acidic functional group of the allergen-inhibiting compound and improving the allergen-inhibiting effect of the allergen inhibitor, it is preferably 4.5 or less.

[0039] As an allergen inhibitory compound, the compounds represented by the following formulas (1) and (2) are preferred. First, the allergen inhibitory compound having the structural formula shown in formula (1) will be described. It should be noted that the allergen inhibitory compound represented by formula (1) can form a hydrate.

[0040] [Chemical formula 1]

[0041]

[0042] In formula (1), R 1 each independently represents a hydrogen atom, -CH 2 -R 3 or -A 1 -R 3 . There are two Rs 1 in the allergen inhibitory compound, and the two Rs 1 can be the same or different from each other. R 3 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group. From the perspective of improving the allergen inhibitory effect of the allergen inhibitor, it is preferably a carboxyl group or a phosphonic acid group, and more preferably a carboxyl group.

[0043] A 1 represents a divalent substituent generated by removing (pulling out) two hydrogen atoms from the carbon atoms of a 4-membered ring, 5-membered ring or 6-membered ring. The carbon atoms from which the hydrogen atoms are removed can be the same or different from each other. The carbon atoms from which the hydrogen atoms are removed (pulled out) are the carbon atoms directly constituting the 4-membered ring, 5-membered ring or 6-membered ring, and do not include the carbon atoms constituting the substituents bonded to the 4-membered ring, 5-membered ring or 6-membered ring. The hydrogen atoms bonded to the carbon atoms of the 4-membered ring, 5-membered ring and 6-membered ring can be substituted by substituents (such as alkyl groups, etc.). A 1 is preferably a divalent substituent generated by removing (pulling out) two hydrogen atoms from the carbon atoms of a benzene ring, an alicyclic 4-membered ring, an alicyclic 5-membered ring or an alicyclic 6-membered ring. A 1 is more preferably a divalent substituent generated by removing (pulling out) two hydrogen atoms from the carbon atoms of a benzene ring, cyclobutane, cyclopentane or cyclohexane.

[0044] R 2 represents -CH 2 -R 4 or -A 2 -R 4 , and R 4 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group. From the perspective of improving the allergen inhibitory effect of the allergen inhibitor, it is preferably a carboxyl group or a phosphonic acid group, and more preferably a carboxyl group.

[0045] A 2Represents a divalent substituent produced by removing (pulling out) two hydrogen atoms from the carbon atoms of a 4-membered ring, 5-membered ring or 6-membered ring. The carbon atoms from which the hydrogen atoms are removed may be the same or different. The carbon atoms from which the hydrogen atoms are removed (pulled out) are the carbon atoms directly constituting the 4-membered ring, 5-membered ring or 6-membered ring, and do not include the carbon atoms constituting the substituents bonded to the 4-membered ring, 5-membered ring or 6-membered ring. The hydrogen atoms bonded to the carbon atoms of the 4-membered ring, 5-membered ring and 6-membered ring may be substituted with substituents (such as alkyl groups, etc.). A 2 Preferably, it is a divalent substituent produced by removing (pulling out) two hydrogen atoms from the carbon atoms of a benzene ring, an alicyclic 4-membered ring, an alicyclic 5-membered ring or an alicyclic 6-membered ring. A 2 Preferably, it is a divalent substituent produced by removing (pulling out) two hydrogen atoms from the carbon atoms of a benzene ring, cyclobutane, cyclopentane or cyclohexane.

[0046] In formula (1), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, R 1 Each independently is preferably -CH 2 -R 3 , more preferably -CH 2 -COOH or -CH 2 -P(=O)(OH) 2 , further preferably -CH 2 -COOH. The two Rs 1 may be the same or different.

[0047] In formula (1), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, R 2 is preferably -CH 2 -R 4 , more preferably -CH 2 -COOH or -CH 2 -P(=O)(OH) 2 , further preferably -CH 2 -COOH.

[0048] In formula (1), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, two or more substituents in R 1 and R 2 are preferably -CH 2 -COOH. That is, as the allergen inhibitory compound represented by formula (1), nitrilotriacetic acid [formula (5)] or iminodiacetic acid [formula (18)] is preferred.

[0049] [Chemical formula 2]

[0050]

[0051] [Chemical formula 3]

[0052]

[0053] In formula (1), starting from the aspect of improving the allergen inhibitory effect of the allergen inhibitor, A 2 is preferably a divalent substituent generated by removing (pulling out) 2 hydrogen atoms from the carbon atoms of a 4-membered or 5-membered ring, and more preferably a divalent substituent generated by removing (pulling out) 2 hydrogen atoms from the carbon atoms of cyclobutane or cyclopentane.

[0054] In formula (1), starting from the aspect of improving the allergen inhibitory effect of the allergen inhibitor, preferably R 2 is -A 2 -R 4 and the two Rs 1 are both hydrogen atoms. In formula (1), more preferably R 2 is -A 2 -R 4 , A 2 is a divalent substituent generated by removing (pulling out) 2 hydrogen atoms from the carbon atoms of a 5-membered or 6-membered ring, and the two Rs 1 are both hydrogen atoms. In formula (1), more preferably R 2 is -A 2 -R 4 , A 2 is a divalent substituent generated by removing (pulling out) 2 hydrogen atoms from the carbon atoms of a benzene ring, an alicyclic 5-membered ring or an alicyclic 6-membered ring, and the two Rs 1 are both hydrogen atoms. In formula (1), preferably R 2 is -A 2 -R 4 , A 2 is a divalent substituent generated by removing (pulling out) 2 hydrogen atoms from the carbon atoms of benzene, cyclopentane or cyclohexane, and the two Rs 1 are both hydrogen atoms. In formula (1), more preferably R 2 is -A 2 -R 4 , A 2 is a divalent substituent generated by removing (pulling out) 2 hydrogen atoms from the carbon atoms of benzene or cyclohexane, and the two Rs 1 are both hydrogen atoms.

[0055] In formula (1), as R 2 is -A 2 -R 4 and the two Rs 1All are allergen-inhibiting compounds of hydrogen atoms. For example, 1-amino-1-cyclobutanecarboxylic acid [Formula (6)], cyclo-leucine [Formula (7)], 1-aminocyclohexanecarboxylic acid [Formula (8)], 3-aminocyclohexanecarboxylic acid [Formula (9)], 4-aminobenzoic acid [Formula (15)], 3-aminobenzoic acid [Formula (16)], 2-aminobenzoic acid [Formula (17)], etc. are preferred, and 4-aminobenzoic acid [Formula (15)] is more preferred.

[0056] [Chemical formula 4]

[0057]

[0058] Next, the allergen-inhibiting compound having the structural formula shown in Formula (2) will be described. It should be noted that the allergen-inhibiting compound shown in Formula (2) can form a hydrate.

[0059] [Chemical formula 5]

[0060]

[0061] In Formula (2), R 5 represents a hydrogen atom, -CH 2 -R 7 or the structure shown in Formula (3). At least two of the Rs 5 have the structure of -CH 5 -R 2 -R 7 or the structure shown in Formula (3). The four Rs 5 can be the same or different from each other. R 7 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group. R 6 represents -(CH 2 )n- or the structure shown in Formula (4), where n is an integer from 1 to 3.

[0062] [Chemical formula 6]

[0063]

[0064] In Formula (3), R 8 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group. R 9 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group. R 7 ~R 9 can be the same or different from each other.

[0065] [Chemical formula 7]

[0066]

[0067] In Formula (4), R 10represents a carboxyl group, a phosphonic acid group or a sulfonic acid group. Among them, m is an integer from 1 to 3. p is an integer from 1 to 3.

[0068] In formula (2), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, R 7 is preferably a carboxyl group or a phosphonic acid group, more preferably a carboxyl group.

[0069] In formula (2), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, the four Rs 5 are preferably -CH 2 -R 7 .

[0070] In formula (2), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, it is preferred that two Rs 5 have the structure shown in formula (3) and the other two Rs 5 are hydrogen atoms. More preferably, on one nitrogen atom, as R 5 is bonded to a substituent having the structure shown in formula (3) and a hydrogen atom, and on the other nitrogen atom, as R 5 is bonded to a substituent having the structure shown in formula (3) and a hydrogen atom.

[0071] In formula (2), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, among the two Rs bonded to the same nitrogen atom 5 , one R 5 has the structure shown in formula (3) and the other R 5 is a hydrogen atom.

[0072] In formula (3), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, R 8 and R 9 are each preferably a carboxyl group or a phosphonic acid group, more preferably a carboxyl group.

[0073] In formula (2), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, R 6 is preferably -(CH 2 )n-, more preferably -(CH 2 ) 2 - or -(CH 2 ) 3 .

[0074] In formula (4), from the perspective of improving the allergen inhibitory effect of the allergen inhibitor, R 10 is preferably a carboxyl group or a phosphonic acid group, more preferably a carboxyl group.

[0075] As the allergen-inhibiting compound represented by formula (2), ethylenediaminetetraacetic acid [formula (10)], 1,3-diaminopropanetetraacetic acid [formula (11)], ethylenediaminedisuccinic acid [formula (12)], diethylenetriaminepentaacetic acid [formula (13)], ethylenediaminetetra(methylenephosphonic acid) [formula (14)] are preferred.

[0076] [Chemical formula 8]

[0077]

[0078] The allergen inhibitor contains an allergen-inhibiting compound as an active ingredient. The method for producing the allergen inhibitor is not particularly limited, and the allergen inhibitor can be produced by mixing, according to a general method, a compound added as needed with the allergen-inhibiting compound.

[0079] Next, the method of using the allergen inhibitor will be described. The allergen inhibitor exerts an allergen-inhibiting effect on various allergens through the action of the allergen-inhibiting compound.

[0080] Examples of allergens targeted by the allergen inhibitor include: allergens of house dust mites (Der1, Der2), animal allergens such as allergens derived from dogs or cats (Canf1, Feld1), Cryptomeria japonica pollen allergens (Cryj1, Cryj2) suspended in the air, and plant allergens such as pollen. In particular, as effective animal allergens, any one of the allergens of mites (mites, organisms in the class Arachnida, order Acarina, mainly divided into 7 suborders. The dorsal stigma represented by Opilioacarida, the four stigmata represented by hard ticks, the posterior stigmata represented by Ixodes ovatus and Argas japonicus, the middle stigmata represented by Ornithonyssus bacoti and Dermanyssus hirundinis, the anterior stigmata represented by Cheyletus malaccensis and Tarsonemus granarius, the non-stigmata represented by Dermatophagoides farinae and other house dust mites, the non-stigmata represented by Tyrophagus putrescentiae, the hidden stigmata represented by Haplochthonius simplex Willman and Cosmochthonius reticulatus, etc.) can be targeted. However, they are abundant in indoor dust, especially in bedding, and are particularly effective against house dust mites that cause allergic diseases.

[0081] The allergen inhibitor can also be used by being attached (supported) to the surface of base particles. By previously attaching the allergen inhibitory compound to the surface of the base particles, the allergen inhibitor does not form lumps and can be uniformly dispersed in the base material described below. Therefore, the surface area of the allergen inhibitor can be increased, the contact between the allergen inhibitor and the allergen can be sufficiently ensured, and the allergen inhibitory effect of the allergen inhibitor can be fully exerted.

[0082] The base particles to which the allergen inhibitor is attached to the surface are not particularly limited as long as the allergen inhibitory effect of the allergen inhibitor is not inhibited. The base particles include resin particles and inorganic particles. The base particles can be used alone or two or more kinds can be used in combination.

[0083] Examples of the synthetic resin constituting the resin particles include styrene resins, acrylic resins, urethane resins, vinyl chloride resins, ABS resins; synthetic rubbers such as styrene-butadiene rubber (SBR) and nitrile-butadiene rubber (NBR), etc., and acrylic resins and styrene resins are preferred, and polystyrene is more preferred.

[0084] The styrene resin is not particularly limited. For example, homopolymers or copolymers containing styrene monomers such as styrene, methylstyrene, ethylstyrene, isopropylstyrene, dimethylstyrene, chlorostyrene, and bromostyrene as monomer units, copolymers containing styrene monomers and one or more vinyl monomers copolymerizable with the styrene monomers as monomer units, etc.

[0085] Examples of the vinyl monomer copolymerizable with the styrene monomer include acrylic monomers such as acrylonitrile, methacrylonitrile, acrylic acid, methacrylic acid, acrylate (such as methyl acrylate, ethyl acrylate, butyl acrylate, etc.), methacrylate (such as methyl methacrylate, ethyl methacrylate, butyl methacrylate, etc.), maleic anhydride, acrylamide, etc.

[0086] The acrylic resin is not particularly limited. For example, homopolymers or copolymers containing acrylic monomers such as (meth)acrylic acid methyl ester, (meth)acrylic acid ethyl ester, (meth)acrylic acid butyl ester, (meth)acrylic acid pentyl ester, etc. as monomer units, copolymers containing acrylic monomers and one or two or more vinyl monomers copolymerizable with the acrylic monomers as monomer units, etc. It should be noted that (meth)acrylate means acrylate or methacrylate.

[0087] Examples of the vinyl monomer copolymerizable with the acrylic monomer include acrylonitrile, methacrylonitrile, maleic anhydride, acrylamide, etc.

[0088] The inorganic compound (inorganic material) constituting the inorganic particles is not particularly limited, and examples thereof include zeolite, hydrotalcite, calcium carbonate, calcium citrate, magnesium carbonate, magnesium hydroxide, and the like.

[0089] The synthetic resin constituting the resin particles preferably contains an aromatic ring. The aromatic ring attracts the hydrophobic part of the allergen-inhibiting compound attached to the surface of the resin particles, plays a role in orienting the acidic functional groups outward, and can more effectively exert the allergen-inhibiting effect of the allergen inhibitor.

[0090] The aromatic ring may be a monocyclic aromatic ring or a monocyclic aromatic ring complexed and fused (fused aromatic ring). The aromatic ring is not particularly limited, and examples thereof include a benzene ring, a naphthalene ring, an anthracene ring, biphenyl, phenoxyphenyl, and the like. Regarding the aromatic ring, any one or more of the hydrogen atoms bonded to the carbon atoms directly constituting the aromatic ring or the fused aromatic ring are removed and bonded to other atoms by a covalent bond.

[0091] Regarding the amount of the allergen-inhibiting compound attached to the base particles, it is preferably 1 part by mass or more, more preferably 5 parts by mass or more, more preferably 7 parts by mass or more, and more preferably 10 parts by mass or more based on 100 parts by mass of the base particles. When the amount of the allergen-inhibiting compound attached is 1 part by mass or more, the allergen inhibitor can be uniformly attached to the surface of the base particles, and the allergen-inhibiting effect of the allergen inhibitor can be more effectively exerted.

[0092] Regarding the amount of the allergen-inhibiting compound attached to the base particles, it is preferably 50 parts by mass or less, more preferably 40 parts by mass or less, more preferably 30 parts by mass or less, and more preferably 20 parts by mass or less based on 100 parts by mass of the base particles. When the amount of the allergen-inhibiting compound attached is 50 parts by mass or less, the allergen inhibitors do not bind to each other, the allergen inhibitors are effectively arranged on the surface of the base particles, and the allergen-inhibiting effect is improved.

[0093] The method for attaching the allergen inhibitor to the surface of the base particles is not particularly limited. For example, the adhesive force of the allergen inhibitor can be utilized, or an adhesive resin can be used to bond the allergen inhibitor to the surface of the base particles. From the perspective of being able to effectively exert the allergen-inhibiting effect of the allergen inhibitor, it is preferable to attach the allergen-inhibiting compound to the surface of the base particles by using the adhesive force of the allergen-inhibiting compound itself.

[0094] Allergen inhibitors are used, for example, in a substrate where an allergen inhibitory effect is desired, to form an allergen inhibitory product. The substrate containing the allergen inhibitor exhibits an allergen inhibitory effect as an allergen inhibitory product. The manner of containing the allergen inhibitor in the substrate is not particularly limited, and examples thereof include a manner in which the allergen inhibitor is attached to the surface of the substrate and a manner in which the allergen inhibitor is mixed into the substrate.

[0095] The allergen inhibitor is dissolved or dispersed in a solvent to prepare an allergen inhibitor solution or an allergen inhibitor dispersion, and the allergen inhibitor solution or the allergen inhibitor dispersion is applied to the substrate, whereby the allergen inhibitor can be attached to the surface of the substrate.

[0096] It should be noted that examples of the solvent include water (preferably ion-exchanged water), alcohols (such as methanol, ethanol, and propanol), hydrocarbons (such as toluene, xylene, methylnaphthalene, kerosene, and cyclohexane), ethers (such as diethyl ether, tetrahydrofuran, and dioxane), ketones (such as acetone and methyl ethyl ketone), amides (such as N,N-dimethylformamide), etc., and water and alcohols are preferred.

[0097] The allergen inhibitor solution or the allergen inhibitor dispersion can be attached to the surface of the substrate by spraying. That is, the allergen inhibitor solution or the allergen inhibitor dispersion can be filled in a spray-type spray container for use.

[0098] The content of the allergen inhibitor in 100% by mass of the allergen inhibitor solution is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and still more preferably 1% by mass or more. The content of the allergen inhibitor in 100% by mass of the allergen inhibitor solution is preferably 40% by mass or less, more preferably 30% by mass or less.

[0099] The allergen inhibitor solution may contain additives such as aqueous solutions, oils, emulsions, and suspending agents as needed.

[0100] The content of the allergen inhibitor in 100% by mass of the allergen inhibitor dispersion is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and still more preferably 1% by mass or more. The content of the allergen inhibitor in 100% by mass of the allergen inhibitor dispersion is preferably 40% by mass or less, more preferably 30% by mass or less.

[0101] The allergen inhibitor dispersion may contain additives such as dispersants and thickeners as needed.

[0102] Examples of the dispersant include surfactants such as anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants. As the dispersant, from the viewpoint of improving the dispersibility of the allergen inhibitor in the solution, anionic surfactants are preferred.

[0103] Examples of anionic surfactants include aromatic sulfonates such as alkylbenzene sulfonates, salts of naphthalene sulfonic acid formalin condensates, and polystyrene sulfonates, alkane sulfonates, α-sulfo fatty acid salts, alkyl sulfosuccinates, α-olefin sulfonates, alkyl sulfates, alkyl sulfate esters, alkyl ethoxysulfate esters, and phosphate esters.

[0104] Examples of cationic surfactants include fatty amine salts, quaternary ammonium salts, and alkylpyridinium salts.

[0105] Examples of nonionic surfactants include polyoxyethylene derivatives such as polyoxyethylene obtained by polymerizing and adding styrene, propylene, butene and other oligomers - phenol complexes or tribenzylated phenol on polyoxyethylene, polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether and other long-chain alkyl - phenyl ethers of polyoxyethylene, polyoxyalkylene alkyl ethers, polyoxyalkylene fatty acid esters, polyoxyethylene polyol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, fatty acid monoglycerides, glycerol fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, and fatty acid alkanolamides.

[0106] Examples of amphoteric surfactants include tertiary amine oxides, betaines, and alkyl betaines.

[0107] As the thickener, it may be a natural polymer compound or a synthetic polymer compound. Examples of natural polymer compounds include pectin, gelatin, carrageenan, xanthan gum, gum arabic, glucomannan, gellan gum, and alginic acid. Examples of synthetic polymer compounds include polyethylene glycol, polyvinyl alcohol, and polyacrylic acid.

[0108] As the substrate for containing the allergen inhibitor, there is no particular limitation as long as it can contain the allergen inhibitor. Examples include synthetic resin molded articles, coatings, coating films, wallpapers, decorative sheets, floor materials, fibers, fiber products (fabrics, non-woven fabrics, knitted fabrics), interior products and interior materials for vehicles (such as cars, airplanes, ships, etc.) (seats, child seats and foams constituting them, etc.), kitchen utensils, baby products, and building interior materials.

[0109] The building interior materials are not particularly limited. Examples include floor materials, wallpapers, ceiling materials, coatings, doorknobs, switches, switch covers, waxes, etc.

[0110] The vehicle interior products and vehicle interior materials are not particularly limited. Examples include seats, child seats, seat belts, seat cushions, seat covers, doors, ceiling materials, floor mats, door interiors, instrument panels, consoles, glove boxes, grab handles, armrests, etc.

[0111] The synthetic resin constituting the synthetic resin molded body is not particularly limited. For example, thermoplastic resins (such as polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyvinyl acetate, polyurethane, TEFLON (registered trademark), acrylonitrile-butadiene-styrene resin, acrylonitrile-styrene resin, acrylic resin, polyvinyl alcohol, polyamide, polyacetal, polycarbonate, modified polyphenylene ether, polyester, polyethylene terephthalate, polybutylene terephthalate, cyclic polyolefin, polyphenylene sulfide, polytetrafluoroethylene, polysulfone, polyethersulfone, polyarylate, polyetheretherketone, thermoplastic polyimide, polyamideimide, etc.), thermosetting resins (such as phenolic resin, epoxy resin, melamine resin, urea resin, unsaturated polyester resin, alkyd resin, polysiloxane resin, polyurethane, thermosetting polyimide, etc.), etc. It should be noted that the synthetic resin can be used alone or in combination of two or more.

[0112] The allergen inhibitor can be mixed into the synthetic resin for use. As a method of mixing the allergen inhibitor into the synthetic resin, the allergen inhibitor can be mixed into the synthetic resin as a raw material to prepare a resin composition, and the resin composition is used to obtain an allergen-inhibiting product with a desired shape in the form of a molded article by a general molding method of synthetic resin. As a general molding method of synthetic resin, for example, an extrusion molding method, an injection molding method, a blow molding method, etc. can be cited. It is also possible to mix the synthetic resin and the allergen inhibitor to make a masterbatch for synthetic resin molding containing the synthetic resin and the allergen inhibitor, mix the masterbatch for synthetic resin molding into the synthetic resin as a raw material, and use a general molding method of synthetic resin to manufacture an allergen-inhibiting product as a synthetic resin molded body.

[0113] The content of the allergen inhibitor in 100% by mass of the masterbatch for synthetic resin molding is preferably 5% by mass or more, more preferably 10% by mass or more. The content of the allergen inhibitor in 100% by mass of the masterbatch for synthetic resin molding is preferably 80% by mass or less, more preferably 70% by mass or less.

[0114] The content of the allergen inhibitor in 100% by mass of the synthetic resin molded body is preferably 1% by mass or more, more preferably 3% by mass or more. The content of the allergen inhibitor in 100% by mass of the synthetic resin molded body is preferably 40% by mass or less, more preferably 30% by mass or less.

[0115] An allergen inhibitor can be physically fixed to fibers to produce allergen-inhibiting fibers. As a method for physically fixing an allergen inhibitor to fibers, for example, the following can be cited: (1) preparing an allergen inhibitor solution by dissolving or dispersing an allergen inhibitor in a solvent, immersing the fibers in the allergen inhibitor solution, and impregnating the fibers with the allergen inhibitor solution; (2) coating or spraying the allergen inhibitor solution on the fiber surface; (3) immersing the fibers in an adhesive resin in which the allergen inhibitor is dissolved or dispersed, and fixing the allergen inhibitor to the fibers through the adhesive resin; (4) coating or spraying the adhesive resin in which the allergen inhibitor is dissolved or dispersed on the fiber surface, and fixing the allergen inhibitor to the fibers through the adhesive resin, etc. It should be noted that in the methods (1) and (2), the allergen inhibitor solution may contain an adhesive resin. The solvent is the same as above, so the description is omitted.

[0116] The adhesive resin is not particularly limited as long as it can fix the allergen inhibitor to the fiber surface. For example, as the adhesive resin, urethane resins such as one-component polyurethane resin and two-component polyurethane resin, polysiloxane resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, epoxy acrylate resins, etc. can be cited, and urethane resins are preferred.

[0117] The allergen inhibitor can be contained in a coating and used as an allergen-inhibiting coating. As the coating, conventionally known coatings can be used, for example, oil-based coatings (such as enamel paints, oil varnishes, etc.), cellulose coatings, synthetic resin coatings, etc. The coating also includes a photocurable coating that polymerizes and forms an adhesive resin by irradiation with radiation such as ultraviolet rays.

[0118] In the coating, additives such as pigments, plasticizers, curing agents, extenders, fillers, anti-aging agents, thickeners, and surfactants can be contained within a range that does not impair its physical properties. It should be noted that as a method for including an allergen inhibitor in the coating, for example, a method of supplying the allergen inhibitor and the coating to a dispersion device and uniformly mixing them can be cited. It should be noted that as the dispersion device, for example, a high-speed mill, a ball mill, a sand mill, etc. can be cited.

[0119] The content of the allergen inhibitor in 100% by mass of the allergen-inhibiting coating is preferably 1% by mass or more, more preferably 3% by mass or more, and still more preferably 5% by mass or more. The content of the allergen inhibitor in 100% by mass of the allergen-inhibiting coating is preferably 40% by mass or less, more preferably 30% by mass or less.

[0120] The content of the allergen inhibitor in the allergen-inhibiting product is preferably 1% by mass or more, more preferably 3% by mass or more, and still more preferably 5% by mass or more based on 100% by mass. The content of the allergen inhibitor in the allergen-inhibiting coating is preferably 40% by mass or less, more preferably 30% by mass or less based on 100% by mass.

[0121] Examples

[0122] Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited thereto.

[0123] As the allergen-inhibiting compounds, the following compounds were prepared. These allergen-inhibiting compounds were used as the allergen inhibitor.

[0124] · 4-Aminobenzoic acid

[0125] · Nitrilotriacetic acid [Formula (5)]

[0126] · 1,3-Diaminopropanetetraacetic acid [Formula (11)]

[0127] · Diethylenetriaminepentaacetic acid [Formula (13)]

[0128] · Iminodiacetic acid [Formula (18)]

[0129] · Ethylenediaminedisuccinic acid trihydrate (trihydrate of the compound shown in Formula (12))

[0130] · Ethylenediaminetetra(methylenephosphonic acid) [Formula (14)]

[0131] · Sebacic acid

[0132] · Suberic acid

[0133] · Benzoic acid

[0134] · Diethylenetriaminepentaacetic acid iron diammonium salt

[0135] The nitrogen atom content in the allergen-inhibiting compounds and the pH of a 0.5% by mass aqueous solution of the allergen-inhibiting compounds at 25°C are shown in the columns of "nitrogen content" and "pH (25°C)" in Table 1, respectively.

[0136] (Examples 1 to 7 and Comparative Examples 1 to 4)

[0137] An allergen inhibitor containing the allergen-inhibiting compounds shown in Table 2 (100% by mass) was prepared.

[0138] For the allergen inhibitor, an anti-allergen test was conducted using mite allergen (Derf1) and pollen allergen (Cryj1), and the results are shown in Table 2.

[0139] (Drug - Anti-allergen test)

[0140] [Mite allergen]

[0141] Dissolve the freeze-dried powder of mite allergen (Derf1) (trade name "Mite Extract-Df" manufactured by COSMO BIO Co., Ltd.) in phosphate buffer (pH 7.6) to prepare an allergen stock solution with a protein mass of 20 μg / mL.

[0142] Add ion-exchanged water to the allergen inhibitor containing the allergen inhibitory compound to prepare a diluted solution of the allergen inhibitor with a concentration of the allergen inhibitory compound of 1% by mass.

[0143] Next, prepare a test tube supplied with 1 mL of the above-mentioned allergen stock solution, add 100 μL of the diluted solution of the allergen inhibitor to the test tube, and shake it at 25°C for 16 hours to prepare a test solution.

[0144] Next, use a measurement reagent (trade name "ELISA Kit for Measuring Mite Allergen Derf1" manufactured by Nitchi Pharmaceutical Co., Ltd., Japan) to measure the amount of Derf1 present, W 1 (ng / mL).

[0145] In addition, except for preparing the test solution without adding the allergen inhibitor solution to the test tube, measure the amount of Derf1 present, W 0 (ng / mL) in the test solution in the test tube in the same manner as described above.

[0146] Calculate the allergen inhibition rate (%) based on the following formula. Record the obtained results in the column of "Mite (Derf1)" under "Agent" in Table 2 for "Allergen Inhibition Rate (%)".

[0147] Allergen inhibition rate (%) = 100 - (W 1 / W 0 ) × 100

[0148] [Pollen allergen]

[0149] Instead of using mite allergen (Derf1), use the freeze-dried powder of pollen allergen (Cryj1) (trade name "Cryptomeria japonica pollen extract" manufactured by ITEA Co., Ltd.), and instead of using the measurement reagent (trade name "ELISA Kit for Measuring Mite Allergen Derf1" manufactured by Nitchi Pharmaceutical Co., Ltd., Japan), use the measurement reagent (trade name "ELISA Kit for Measuring Cryptomeria japonica Pollen Allergen Cryj1" manufactured by Nitchi Pharmaceutical Co., Ltd., Japan). Except for this, measure the allergen inhibition rate in the same manner as when using mite allergen (Derf1). Record the obtained results in the column of "Pollen (Cryj1)" under "Agent" in Table 2 for "Allergen Inhibition Rate (%)".

[0150] (Coating film - anti - allergen test)

[0151] As the mite allergen (Derf1) and the assay reagent, and the pollen allergen (Cryj1) and the assay reagent, the same reagents as those used in the (pharmaceutical - anti - allergen test) are used.

[0152] Relative to 10 parts by mass of the allergen inhibitor obtained in the examples and comparative examples, an adhesive resin (trade name “POLYSOL AM - 200” of Showa Denko K.K., solvent: water, solid content: 40 mass%) is added so that the solid content becomes 90 parts by mass, and an allergen - inhibiting coating is prepared. Then, a polyester film is prepared as the substrate. After coating one side of this substrate with the allergen - inhibiting coating so that the dried film thickness is 10 μm, it is dried in an oven at 120 °C for 1 hour to prepare an allergen - inhibiting product having a coating film formed on one side.

[0153] The lyophilized powder of the allergen is separately dissolved in purified water to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, PBS - T (phosphate buffer containing 0.05 mass% Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH: 7.4) is added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0154] The allergen - inhibiting product is cut into a flat square shape with one side being 5 cm. After dropping 0.4 mL of the allergen solution on the coating film, it is left at 25 °C for 24 hours in a state covered with a polyethylene film having a flat square shape with one side being 4 cm to prepare a test solution. Then, the amount of the allergen present W 1 (ng / mL) in the test solution is measured using the assay reagent.

[0155] Instead of the allergen - inhibiting coating, an adhesive resin (trade name “POLYSOL AM - 200” of Showa Denko K.K., solvent: water, solid content: 40 mass%) is used as a blank coating. Otherwise, a blank product having a coating film formed on one side is prepared in the same manner as described above. Except for using the blank product instead of the allergen - inhibiting product, the amount of the allergen present W 0 (ng / mL) in the test solution is measured in the same manner as described above. The allergen inhibition rate (%) is calculated based on the following formula. The obtained results are respectively described in the columns of “mites (Derf1)” and “pollen (Cryj1)” of “coating film” in “allergen inhibition rate (%)” in Table 2.

[0156] Allergen inhibition rate (%) = 100 - (W 1 / W 0 )×100

[0157] (Fiber-Allergen Test)

[0158] As the mite allergen (Derf1) and the assay reagent, and the pollen allergen (Cryj1) and the assay reagent, the same reagents as those used in the (Drug-Allergen Test) are used.

[0159] Purified water was added to 1 g of the allergen inhibitor obtained in the examples and comparative examples and mixed uniformly to prepare an allergen inhibitor dispersion containing 1% by mass of the allergen inhibitor.

[0160] Next, as the substrate, polyester fiber (trade name “Polyester Tropical Toray” manufactured by SHIKISENSHA Co., Ltd., unit area weight: 120 g / m 2 ) was prepared. The fiber was immersed in 100 g of the allergen inhibitor dispersion for 2 minutes. The impregnated polyester fiber was pressed with a manual wringer and dried at 120 °C for 10 minutes to prepare an allergen-inhibiting fiber with the allergen inhibitor fixed on the polyester fiber. In the allergen-inhibiting fiber, the allergen inhibitor contained 1 g / m 2 .

[0161] The freeze-dried powder of the allergen was dissolved in purified water respectively to prepare an allergen aqueous solution containing 10 μg / mL of the allergen. Then, PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH: 7.4) was added to the allergen aqueous solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of the allergen.

[0162] 0.4 g of the allergen-inhibiting fiber was placed in a zip-lock plastic bag, 1 mL of the allergen solution was added dropwise, sealed, and left at 25 °C for 2 hours to prepare a test solution.

[0163] Next, the assay reagent was used to measure the amount W 1 (ng / mL) of the allergen present in the test solution.

[0164] Except for not adding the allergen-inhibiting fiber in the zip-lock plastic bag, the amount W 0 (ng / mL) of the allergen present in the test solution was measured in the same manner as described above. The allergen inhibition rate (%) was calculated based on the following formula. The results obtained were recorded in the columns of “Mite (Derf1)” and “Pollen (Cryj1)” under “Fiber” in Table 2 for “Allergen Inhibition Rate (%)”.

[0165] Allergen inhibition rate (%) = 100 - (W 1 / W 0)×100

[0166] (Spray - anti - allergen test)

[0167] Mix 5 parts by mass of the allergen inhibitor obtained in Examples 1, 5 and 6, 5 parts by mass of polyethylene glycol (manufactured by Wako Pure Chemical Industries, Ltd.: Mw7500), and 90 parts by mass of water to prepare an aqueous solution of the allergen inhibitor. Fill the obtained aqueous solution of the allergen inhibitor into a spray - type spray container so as to spray it uniformly onto polyester fiber (trade name “Polyester Tropical Toray” manufactured by SHIKISENSHA, unit area weight: 120 g / m2) at a rate of 4 μL / cm 2 , and leave it to dry at room temperature for 8 hours to prepare allergen - inhibitory fibers.

[0168] Using the obtained allergen - inhibitory fibers, calculate the allergen inhibition rate (%) in the same manner as in the (fiber - anti - allergen test). Record the obtained results in the columns of “Mite (Derf1)” and “Pollen (Cryj1)” under “Spray” of “Allergen inhibition rate (%)” in Table 2 respectively.

[0169] (Molded body - anti - allergen test)

[0170] As the mite allergen (Derf1) and the assay reagent, and the pollen allergen (Cryj1) and the assay reagent, use the same reagents as those used in the (drug - anti - allergen test).

[0171] Melt - knead and mix 50 parts by mass of the allergen inhibitor obtained in Examples 2 - 5 and Comparative Examples 1 - 3 and 50 parts by mass of polypropylene (trade name “NOVATEC PP BC6C” manufactured by JAPANPOLYPROPYLENE) to prepare a masterbatch for synthetic resin molding.

[0172] Melt - knead 30 parts by mass of the obtained masterbatch for synthetic resin molding and 70 parts by mass of separately prepared polypropylene (trade name “NOVATEC PP BC6C” manufactured by JAPANPOLYPROPYLENE) at 180 °C for 5 minutes to prepare a resin composition. Perform compression molding on the obtained resin composition to obtain a sheet - like synthetic resin molded body with an average thickness of 1 mm.

[0173] In addition, prepare a sheet - like synthetic resin molded body with an average thickness of 1 mm composed only of polypropylene (trade name “NOVA TEC PPBC6C” manufactured by JAPAN POLYPROPYLENE), and use this synthetic resin molded body as a blank synthetic resin molded body.

[0174] Using a synthetic resin molded body containing an allergen inhibitor and a blank synthetic resin molded body, calculate the allergen inhibition rate (%) in the same manner as in the (coating film - anti - allergen test). Record the obtained results in the columns of "mite (Derf1)" and "pollen (Cryj1)" under "molded body" of "allergen inhibition rate (%)" in Table 2 respectively.

[0175] [Table 1]

[0176]

[0177] [Table 2]

[0178]

[0179] Industrial applicability

[0180] The allergen inhibitor of the present invention can effectively inhibit the reaction between an allergen and a specific antibody. An allergen - inhibiting product having an excellent allergen - inhibiting effect can be manufactured by including the allergen inhibitor in a substrate.

[0181] (Cross - reference to related applications)

[0182] This application claims priority based on Japanese Patent Application No. 2022 - 167899 filed on October 19, 2022, and the disclosure of this application is incorporated into this specification by reference in its entirety.

Claims

1. An allergen inhibitor, comprising: An allergen-inhibiting compound having one or more acidic functional groups, wherein the acidic functional groups are bonded to a nitrogen atom through one or more carbon atoms.

2. The allergen inhibitor according to claim 1, wherein, The acidic functional group is a carboxyl group, a phosphonic acid group or a sulfonic acid group.

3. The allergen inhibitor according to claim 1 or 2, wherein, The allergen-inhibiting compound is represented by formula (1), [Chemical formula 1] In formula (1), R 1 each independently represents a hydrogen atom, -CH 2 -R 3 or -A 1 -R 3 , two Rs 1 may be the same or different from each other, R 3 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group, A 1 represents a divalent substituent formed by removing two hydrogen atoms from the carbon atoms of a 4-membered ring, 5-membered ring or 6-membered ring, R 2 represents -CH 2 -R 4 or -A 2 -R 4 , R 4 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group, A 2 represents a divalent substituent formed by removing two hydrogen atoms from the carbon atoms of a 4-membered ring, 5-membered ring or 6-membered ring.

4. The allergen inhibitor according to claim 1 or 2, wherein, The allergen-inhibiting compound is represented by formula (2), [Chemical formula 2] In formula (2), R 5 represents a hydrogen atom, -CH 2 -R 7 or the structure represented by formula (3), and at least two Rs 5 have the structure of -CH 2 -R 7 or the structure represented by formula (3). The four Rs 5 can be the same or different from each other. R 7 to R 9 each represent a carboxyl group, a phosphonic acid group or a sulfonic acid group, and R 6 represents -(CH 2 )n- or the structure represented by formula (4), where n is an integer from 1 to 3. [Chemical formula 3] [Chemical formula 4] In formula (4), R 10 represents a carboxyl group, a phosphonic acid group or a sulfonic acid group, where m is an integer from 1 to 3 and p is an integer from 1 to 3.

5. The allergen inhibitor according to claim 1 or 2, wherein, The acidic functional group is a carboxyl group or a phosphonic acid group.

6. The allergen inhibitor according to claim 1 or 2, wherein, The content of nitrogen atoms in the allergen-inhibiting compound is 5% to 12%.

7. The allergen inhibitor according to claim 1 or 2, wherein, The acidic functional group is a carboxyl group.

8. The allergen inhibitor according to claim 1 or 2, wherein, The pH of a 0.5 mass% aqueous solution of the allergen-inhibiting compound at 25 °C is 4.5 or less.

9. An allergen-inhibiting product, comprising: A substrate, and The allergen inhibitor according to claim 1 or 2 contained in the substrate.

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