Scalp micro-ecological repair aerosol and preparation method thereof

Abstract

The invention relates to the technical field of daily chemical products, and discloses a scalp micro-ecological repair aerosol. The scalp micro-ecological repair aerosol is prepared from the following effective components in parts by weight: 5 to 10 parts of emulsified castor oil, 1 to 2 parts of L-sodium pyrrolidone carboxylate, 0.5 to 1.0 part of rhizoma chuanxiong extract, 0.5 to 1.0 part of tea seed oil, 0.3 to 0.5 part of composite micro-film aid, 0.1 to 0.2 part of sodium hyaluronate, 0.1 to 0.2 part of beta-glucan, 0.1 to 0.2 part of alpha-glucan oligosaccharide, 0.05 to 0.1 part of isopropyl myristate and 0.05 to 0.1 part of DL-panthenol, the invention discloses a chamomile essence which is prepared from the following raw materials in parts by weight: 0.05-0.1 part of chamomile extract, 0.05-0.1 part of an emulsifier, 0.01-0.05 part of phospholipid, 0.01-0.03 part of capryloyl glycine, 0.005-0.01 part of 2-alpha glycerol glucoside, 85-90 parts of deionized water, a proper amount of an odorant and a proper amount of lactic acid serving as a pH regulator. According to the invention, polyethylene glycol and frankincense are used as a micro-film auxiliary agent and cooperate with a plurality of compositions, so that the obtained aerosol can significantly improve the scalp micro-ecological environment and balance scalp microbiota.

Description

Technical Field

[0001] The invention belongs to the technical field of daily chemical products, and particularly relates to a scalp microecological repair aerosol and a preparation method thereof. Background Art

[0002] With the changes in the external environment and the pressure of people's work and life, many people have hair quality and scalp problems. Problems such as oily and sticky hair, dry and hard hair, itchy scalp, and increased dandruff are increasing. Although people try to maintain their hair by using functional shampoos, the effect is minimal. The main reason is that the scalp microecology is damaged.

[0003] According to existing research, the scalp mainly maintains the balance of microecology through oil secretion, biological metabolism, and flora, which promotes the scalp to maintain a healthy state, thereby ensuring good hair quality. Once the microecology is disturbed, a chain of adverse reactions will occur. For example, the epidermal keratinocytes shed from the scalp and the oil secreted by the sebaceous glands provide a source of nutrition for microorganisms. If the scalp has abnormal oil secretion from the sebaceous glands, on the one hand, it will be manifested as oily and sticky hair. On the other hand, oil is the main nutrition for the growth of Malassezia flora. Excessive oil secretion will cause Malassezia to multiply rapidly, causing an imbalance in the flora and leading to the production of a large amount of dandruff. Even if an antibacterial shampoo is used to inhibit the reproduction of the flora and alleviate the trouble of dandruff, the microecological problem is not solved, and oil is still secreted in the later stage, and the dandruff problem is prone to recurrence. However, when the scalp hair follicle pores are blocked, the oil secreted by the sebaceous glands cannot be discharged normally, thereby accelerating the excessive reproduction of anaerobic bacteria Propionibacterium acnes colonized in the sebaceous glands, causing damage to the scalp barrier and even leading to hair loss.

[0004] There are many factors that induce imbalance in the scalp microecology, such as endocrine disorders caused by work pressure and lifestyle habits, increased oil secretion; the sebaceous glands themselves secrete sebum due to vigorous hormone secretion; shampoos and conditioners containing irritating ingredients may damage the scalp microecology; frequent use of shampoo damages the scalp microenvironment, disrupts the bacterial flora structure, and breaks the balance of the scalp microecology.

[0005] The stratum corneum is an important barrier of the scalp. Its moisture retention and microecology directly determine the health of the scalp. Generally speaking, in order to maintain the balance of the scalp's microecology, it is first necessary to nourish the scalp and balance the scalp's microbial community to prevent pathogenic microorganisms from colonizing the scalp. In addition, the scalp needs to build a mild protective film to keep the skin moisturized, maintain the weak acid environment of the scalp, and inhibit the invasion of pathogenic bacteria. Therefore, protecting the balance of the scalp's microecology and maintaining the scalp's natural barrier are the key. At present, shampoo is required to maintain the scalp, and its effect in forming a microecology is limited. Summary of the invention

[0006] The scalp has strong sebum secretion, making it prone to problems such as greasy scalp and itching; while the blockage of scalp pores can easily lead to dry hair, follicle shrinkage and hair loss. These intractable scalp problems are mainly caused by the imbalance of scalp microecology. In view of this, the purpose of the present invention is to design a scalp microecology repair aerosol, which can moisturize, nourish the scalp, promote scalp blood circulation, form a mild scalp barrier microfilm on the scalp, enhance the antibacterial ability of the scalp, prevent excessive scalp oil secretion, avoid pore blockage, thereby repairing the scalp microecology and helping the scalp maintain a healthy state. It can repair the scalp by direct spraying, improving the convenience of use, and at the same time ensuring that the active ingredients evenly cover the scalp to form a microenvironment, with no heavy feeling during use.

[0007] In one aspect, the present invention provides a scalp microecology repair aerosol, which is characterized by comprising a scalp microecology repair composition and a propellant; wherein:

[0008] The scalp microecology repair composition comprises the following raw material components by weight: 5 - 10 parts of emulsified castor oil, 1 - 2 parts of L-pyrrolidone carboxylate, 0.5 - 1.0 part of Ligusticum chuanxiong extract, 0.5 - 1.0 part of camellia seed oil, 0.3 - 0.5 part of composite microfilm adjuvant, 0.1 - 0.2 part of sodium hyaluronate, 0.1 - 0.2 part of β-glucan, 0.1 - 0.2 part of α-glucooligosaccharide, 0.05 - 0.1 part of isopropyl myristate, 0.05 - 0.1 part of DL-panthenol, 0.05 - 0.1 part of chamomile extract, 0.05 - 0.1 part of emulsifier, 0.01 - 0.05 part of phospholipid, 0.01 - 0.03 part of octanoyl glycine, 0.005 - 0.01 part of 2-α-glyceryl glucoside, 85 - 90 parts of deionized water, an appropriate amount of flavoring agent, and an appropriate amount of pH regulator; the composite microfilm adjuvant is an emulsion of polyethylene glycol and frankincense ground; the pH regulator is lactic acid, and an appropriate amount is added to adjust the pH value of the scalp microecology repair composition to 4.5 - 5.8;

[0009] The propellant is one of liquefied petroleum gas (LPG), dimethyl ether (DME), carbon dioxide (CO 2 )), nitrogen, 1,1-difluoroethane (HFC-152a), 1,1,1,2-tetrafluoroethane (HFC-134a); the amount of the propellant is 35 - 45% of the total weight of the scalp microecology repair composition.

[0010] Preferably, the emulsified castor oil is obtained by mixing a compound emulsifier, castor oil, and water in a mass ratio of 1:(7 - 8):(7 - 10), and emulsifying at 45 - 50 °C and a rotation speed of 2000 - 3000 r / min for 10 - 15 min in a homogenizer; the compound emulsifier is composed of span 80 and tween 60 compounded in a mass ratio of 3:7. The emulsified castor oil is easy to adhere to the scalp, promotes blood circulation in the scalp, helps hair follicles better absorb nutrients, inhibits seborrheic dermatitis, and maintains the health of the scalp environment.

[0011] L - pyrrolidone carboxylate exists in large amounts in the stratum corneum as the most important component of the body's natural moisturizing factor. The present invention constructs a barrier against water loss by synergistically using L - pyrrolidone carboxylate to supplement the moisturizing factors in the skin stratum corneum.

[0012] The main active ingredients contained in the Ligusticum wallichii extract are phthalides, alkaloids, phenolic acids, polysaccharides, etc. It can effectively promote blood circulation in the scalp and increase hair nutrition; at the same time, it has antioxidant and anti - inflammatory effects, and can actively relieve scalp itching and inflammation.

[0013] On the one hand, camellia seed oil has antibacterial effects and can effectively inhibit the reproduction of Malassezia; on the other hand, it can dissolve isopropyl myristate, phospholipids, and capryloyl glycine to form an oil phase, which is beneficial for the preparation of oil - in - water emulsions and promotes the stable dispersion of isopropyl myristate, phospholipids, and capryloyl glycine in water - based aerosols.

[0014] Preferably, the composite microfilm adjuvant is an emulsion ground from polyethylene glycol and frankincense in a mass ratio of 3 - 5:1; polyethylene glycol and frankincense have good film - forming properties and are easy to form a biocompatible microfilm, which can stabilize the effective components of the scalp microecological repair composition to form a microenvironment on the scalp. Frankincense is the resin exuded from the bark of the Boswellia tree. It is brittle at low temperatures and can form an emulsion when ground with polyethylene glycol. It is easy to disperse in water, has film - forming properties, and at the same time has antioxidant, antibacterial, anti - inflammatory, and skin - repairing effects. It can also give the hair a waxy luster and aroma.

[0015] Preferably, the molecular weight of the sodium hyaluronate is 1.0×10 4 -1.0×10 6 Da; the lower - molecular - weight sodium hyaluronate is easy to absorb.

[0016] β - glucan can adsorb and lock the moisture on the skin surface to form a protective film. At the same time, it has anti - inflammatory effects, inhibits the activation of inflammatory cells, reduces the degree of inflammatory response; inhibits the over - reproduction of harmful bacteria, promotes the growth of beneficial bacteria, and maintains the healthy state of the scalp microecology.

[0017] α-Glucan oligosaccharides can effectively stimulate beneficial microbial flora and promote the reconstruction of skin microbial flora. At the same time, it can promote the growth of skin cells and has the function of promoting skin healing.

[0018] Isopropyl myristate has the effects of penetrating, moisturizing and softening the skin. It can effectively contact with hair follicles in the cortex, penetrate deep into the cortex, and bring active components into it, playing the role of moisturizing and nourishing the skin, preventing water loss from the scalp, and maintaining the stability of the scalp microenvironment.

[0019] DL-Panthenol has a deep penetration effect on the skin, can provide nourishment and protection for the skin, and has the functions of powerful moisturizing, promoting repair, anti-inflammatory and soothing, and antioxidant protection. It can repair the scalp barrier, reduce water loss, and improve symptoms such as dry skin and peeling.

[0020] Chamomile extract has the effect of soothing the skin, can nourish beneficial bacteria, reduce skin inflammatory reactions, and relieve skin discomfort symptoms.

[0021] Preferably, the emulsifier is selected from at least one of Tween-20, Tween-40, Tween-60, and Tween-80.

[0022] Preferably, the phospholipid is selected from at least one of phosphatidylglycerol, phosphatidylserine, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol; the phospholipid can effectively reduce water loss from the scalp, protect the water content of the scalp cutin layer, and has a soothing and repairing effect on the scalp.

[0023] Octanoyl glycine has good antibacterial properties and has strong inhibitory effects on Staphylococcus aureus and Propionibacterium acnes, etc. At the same time, it can also resist the excessive secretion of sebum, so as to have mild antibacterial properties and regulate sebum secretion.

[0024] 2-α-Glyceryl glucoside has good skin permeability, can effectively reduce skin water loss, and at the same time promote the growth of probiotics.

[0025] Preferably, the flavoring agent is added in an appropriate amount as needed and is selected from one or more of menthol, rose ketone, lavender essential oil, jasmine essential oil, rosemary essential oil, lily essence, lemon essence, aloe essence, milk essence, and grass essence.

[0026] Preferably, the pH regulator is selected as lactic acid, and the pH value of the scalp microecological repair composition is adjusted to 5.5 with lactic acid; the pH value environment of a healthy scalp is usually in the weakly acidic range, and the weakly acidic environment helps the scalp to produce a biological protective film and maintain the health and function of the scalp, including resisting bacterial and fungal infections, protecting the structure of the hair, and maintaining the scalp barrier function, etc.

[0027] On the other hand, a preparation method of the above-mentioned scalp microecological repair aerosol is provided, and the specific preparation method is as follows:

[0028] S1. According to the weight parts, 0.05 - 0.1 part of isopropyl myristate, 0.01 - 0.05 part of phospholipid, and 0.01 - 0.03 part of capryloyl glycine are dissolved in 0.5 - 1.0 part of camellia oil to form an oil phase; 0.05 - 0.1 part of an emulsifier is added to the oil phase and stirred at a low speed of 100 - 150 r / min for 10 - 20 min to form a premix; 3 - 5 parts of deionized water are added to a stainless-steel emulsifying tank and stirred at a high speed of 5000 - 12000 r / min, and the premix is dispersed into the continuous phase of deionized water, and the stirring time is controlled at 20 - 35 min to obtain a pre-emulsion;

[0029] S2. According to the weight parts, 82 - 85 parts of deionized water are added to a mixing tank and stirred at a low speed, and then the pre-emulsion prepared in step S1 and 0.3 - 0.5 part of a composite microfilm auxiliary agent are slowly added to the mixing tank and stirred at a low speed for 3 - 5 min to mix evenly. Further, 5 - 10 parts of emulsified castor oil, 1 - 2 parts of sodium L-pyroglutamate, 0.5 - 1.0 part of chuanxiong extract, 0.1 - 0.2 part of sodium hyaluronate, 0.1 - 0.2 part of β-glucan, 0.1 - 0.2 part of α-glucooligosaccharide, 0.05 - 0.1 part of DL-panthenol, 0.05 - 0.1 part of chamomile extract, 0.005 - 0.01 part of 2-α-glyceryl glucoside, and an appropriate amount of a flavoring agent are added and stirred and mixed at a low speed. The pH value is measured, and then the pH regulator lactic acid is added to adjust the pH value to 4.8 - 5.8; it is filtered through a 200-mesh stainless-steel filter screen and discharged to obtain a scalp microecological repair composition;

[0030] S3. The scalp microecological repair composition obtained in step S2 is filled into a tinplate can as a container under normal pressure by metering, sealed, and filled with a propellant. The filling amount of the propellant is 35 - 45% of the total weight of the scalp microecological repair composition. It is weighed and detected, and water-bathed and detected, and then a nozzle is installed to obtain a scalp microecological repair aerosol.

[0031] The present invention relates to a scalp microecological repair aerosol. Through emulsification pretreatment, various oily components are effectively fused, which is beneficial to be dispersed in an aqueous system for use as an aerosol. After the aerosol is sprayed, it is uniform and delicate, evenly dispersed on the scalp without a heavy feeling. By utilizing the synergistic effect of emulsified castor oil, sodium L-pyrrolidone carboxylate, chuanxiong extract, β-glucan, α-glucan oligosaccharide, tea seed oil, isopropyl myristate, sodium hyaluronate, DL-panthenol, chamomile extract, phospholipid, capryloyl glycine, and 2-α-glycosylglucose, it has significant moisturizing, scalp nourishing, blood circulation promoting, and antibacterial effects. The aerosol forms a microenvironment barrier on the scalp through a biocompatible microfilm adjuvant, enabling the synergistic components to balance the scalp microbiota and improve the scalp microecological environment, thereby forming a mild scalp barrier to protect the scalp from external stimuli and prevent scalp dryness and itching.

[0032] When using the scalp microecological repair aerosol, it is directly sprayed on the scalp in the form of aerosol jet and gently massaged to form a mild scalp barrier without the need for rinsing. The scalp microecological repair aerosol is suitable for most people and people with sensitive skin to protect the scalp from external stimuli. However, due to individual differences, a skin adaptability test is required before use to ensure no allergic reaction.

[0033] A scalp microecological repair aerosol and its preparation method according to the present invention have the following beneficial effects:

[0034] 1. By utilizing the synergistic combination of emulsified castor oil, sodium L-pyrrolidone carboxylate, chuanxiong extract, β-glucan, α-glucan oligosaccharide, tea seed oil, isopropyl myristate, sodium hyaluronate, DL-panthenol, chamomile extract, phospholipid, capryloyl glycine, and 2-α-glycosylglucose, the obtained aerosol has the effects of moisturizing, nourishing, promoting blood circulation, and antibacterial on the scalp, and can balance the scalp microbiota and improve the scalp microecological environment.

[0035] 2. By using the emulsion of polyethylene glycol and frankincense ground as a microfilm adjuvant, the formed frankincense microfilm has the effects of antioxidant, antibacterial, anti-inflammatory, and skin repair. It forms a microenvironment barrier film with the rest of the active ingredients on the scalp to soothe the scalp and protect the scalp from external stimuli.

[0036] 3. Through emulsification pretreatment, various oily components are effectively fused, and a milky liquid is formed by grinding the microfilm adjuvant, which is thus beneficial to be dispersed in an aqueous system for use as an aerosol, realizing the uniform and delicate dispersion of the aerosol on the scalp without a heavy feeling.

[0037] 4. The raw materials used in the aerosol of the present invention are safe and easy to purchase, and are suitable for batch production. Specific embodiments

[0038] To enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be understood below in conjunction with examples and comparative examples. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. In view of the use of a variety of effective raw material compositions in the aerosol of the present invention, the comparative examples do not conduct a comprehensive comparative analysis, but the final synergistic effect of its various compositions is significant. The emulsified castor oil and the composite microfilm auxiliary used in the embodiments of the present invention are self-made. The remaining raw materials are all commercially available raw materials of cosmetic grade or food grade.

[0039] Self-made emulsified castor oil: Mix 3 kg of span 80, 7 kg of tween 60, and 80 kg of castor oil evenly under the condition of 50 °C to obtain an oil phase; add 100 kg of deionized water to the emulsification tank, set the constant temperature at 50 °C, stir at a high speed of 3000 r / min, add the oil phase to the emulsification tank, and emulsify for 15 min to obtain the emulsified castor oil for standby.

[0040] Self-made composite microfilm auxiliary: Crush frankincense and sieve it through a 80-mesh sieve to obtain frankincense powder, then mix polyethylene glycol 400 and frankincense powder in a mass ratio of 4:1, add it to a ball mill made of stainless steel inner cylinder material, use zirconia ceramic balls as the grinding medium, and grind for 60 min to obtain a milky composite microfilm auxiliary for standby.

[0041] Sodium hyaluronate: The molecular weight is 1.0×10 4 -2.0×10 5 Da, provided by Zhejiang Zancheng Biotechnology Co., Ltd.

[0042] Example 1

[0043] S1. Dissolve 0.05 part of isopropyl myristate, 0.01 part of phosphatidylserine, and 0.02 part of octanoyl glycine in 0.7 part of camellia oil by weight to form an oil phase; add 0.08 part of emulsifier tween-40 to the oil phase and stir at a low speed of 100 r / min for 10 min to form a premix; add 4 parts of deionized water to a stainless steel emulsification tank, stir at a high speed of 12000 r / min, disperse the premix into the deionized water continuous phase, and control the stirring time at 35 min to obtain a pre-emulsion;

[0044] S2. By weight, add 83 parts of deionized water to the mixing tank and stir at a low speed of 100 r / min. While stirring, slowly add the pre-emulsion prepared in step S1 and 0.4 part of the composite microfilm adjuvant to the mixing tank and continue to stir at a low speed for 5 min to mix evenly. Further add 8 parts of emulsified castor oil, 2 parts of sodium L-pyrrolidone carboxylate, 0.5 part of Ligusticum chuanxiong extract, 0.1 part of sodium hyaluronate, 0.1 part of β-glucan, 0.1 part of α-glucooligosaccharide, 0.05 part of DL-panthenol, 0.05 part of chamomile extract, 0.01 part of 2-α-glyceryl glucoside, and 0.3 part of rosemary essential oil and stir at a low speed to mix. Dynamically monitor the pH using an immersion pH meter, and then slowly add the pH regulator lactic acid in multiple portions until the pH meter shows a pH value of 5.52 and stop adding lactic acid; filter the product through a 200-mesh stainless steel filter to obtain the scalp microecological repair composition;

[0045] S3. Use a tinplate can as the container to metrologically fill, seal the valve, and charge the propellant LPG into the scalp microecological repair composition obtained in step S2 at normal pressure. The charging amount of the propellant is 35% of the total weight of the scalp microecological repair composition. Weigh and detect, and conduct a water bath test, and then install a nozzle to obtain a scalp microecological repair aerosol.

[0046] Example 2

[0047] S1. By weight, dissolve 0.1 part of isopropyl myristate, 0.05 part of phosphatidylglycerol, and 0.01 part of capryloyl glycine in 0.5 part of camellia oil to form an oil phase; add 0.06 part of emulsifier Tween-60 to the oil phase and stir at a low speed of 100 r / min for 10 min to form a pre-mixture; add 5 parts of deionized water to a stainless steel emulsifying tank and stir at a high speed of 8000 r / min to disperse the pre-mixture into the deionized water continuous phase, and control the stirring time at 25 min to obtain a pre-emulsion;

[0048] S2. By weight, add 85 parts of deionized water to the mixing tank and stir at a low speed of 100 r / min. While stirring, slowly add the pre-emulsion prepared in step S1 and 0.5 part of the composite microfilm adjuvant to the mixing tank and continue to stir at a low speed for 5 min to mix evenly. Further add 10 parts of emulsified castor oil, 1.5 parts of sodium L-pyrrolidone carboxylate, 0.8 part of Ligusticum chuanxiong extract, 0.1 part of sodium hyaluronate, 0.2 part of β-glucan, 0.2 part of α-glucooligosaccharide, 0.05 part of DL-panthenol, 0.05 part of chamomile extract, 0.008 part of 2-α-glyceryl glucoside, and 0.2 part of grass essence and stir at a low speed to mix. Dynamically monitor the pH using an immersion pH meter, and then slowly add the pH regulator lactic acid in multiple portions until the pH meter shows a pH value of 5.47 and stop adding lactic acid; filter the product through a 200-mesh stainless steel filter to obtain the scalp microecological repair composition;

[0049] S3. The scalp microecological repair composition obtained in step S2 is filled into a tinplate can at normal pressure by metering, the valve is sealed, and the propellant nitrogen is filled. The filling amount of the propellant is 40% of the total weight of the scalp microecological repair composition. After weighing and water bath testing, a nozzle is installed to obtain a scalp microecological repair aerosol.

[0050] Example 3

[0051] S1. 0.08 parts of isopropyl myristate, 0.05 parts of phosphatidylcholine, and 0.02 parts of capryloyl glycine are dissolved in 1 part of camellia oil by weight to form an oil phase; 0.1 part of emulsifier Tween-80 is added to the oil phase and stirred at a low speed of 150 r / min for 15 min to form a premix; 3 parts of deionized water are added to a stainless steel emulsification tank and stirred at a high speed of 10,000 r / min. The premix is dispersed into the continuous phase of deionized water, and the stirring time is controlled at 30 min to obtain a pre-emulsion.

[0052] S2. By weight, 85 parts of deionized water are added to a mixing tank and stirred at a low speed of 100 r / min. While stirring, the pre-emulsion prepared in step S1 and 0.5 parts of the composite microfilm adjuvant are slowly added to the mixing tank and continuously stirred at a low speed for 5 min to mix evenly. Further, 6 parts of emulsified castor oil, 1 part of L-pyrrolidone carboxylate, 0.8 part of Ligusticum chuanxiong extract, 0.1 part of sodium hyaluronate, 0.2 part of β-glucan, 0.1 part of α-glucooligosaccharide, 0.1 part of DL-panthenol, 0.1 part of chamomile extract, 0.01 part of 2-α-glyceryl glucoside, and 0.4 part of jasmine essential oil are added and stirred at a low speed. The pH is dynamically monitored using an immersion pH meter, and then the pH regulator lactic acid is slowly added in multiple times until the pH meter shows a pH value of 5.22 and then the addition of lactic acid is stopped; the mixture is filtered through a 200-mesh stainless steel filter and discharged to obtain a scalp microecological repair composition.

[0053] S3. The scalp microecological repair composition obtained in step S2 is filled into a tinplate can at normal pressure by metering, the valve is sealed, and the propellant carbon dioxide is filled. The filling amount of the propellant is 37% of the total weight of the scalp microecological repair composition. After weighing and water bath testing, a nozzle is installed to obtain a scalp microecological repair aerosol.

[0054] Comparative Example 1

[0055] The difference from Example 1 is that the composite microfilm adjuvant is not used in the formulation, and 0.4 parts of polyethylene glycol 400 is used instead. Due to the absence of the microenvironment barrier film of frankincense microfilm with antioxidant, antibacterial, anti-inflammatory, and skin repair effects, the soothing and repair effects of the aerosol on the scalp are affected.

[0056] Comparative Example 2

[0057] The difference from Example 1 is that emulsified castor oil is not used in the ingredients, and 8 parts of deionized water are used instead of emulsified castor oil. Due to the absence of emulsified castor oil, the aerosol of emulsified castor oil has a poor dispersion and adhesion effect on the scalp, which cannot well promote the blood circulation of the scalp, and the effect of inhibiting seborrheic dermatitis is limited.

[0058] Comparative Example 3

[0059] The difference from Example 1 is that β-glucan and α-glucan oligosaccharide are not used in the ingredients, and 0.2 parts of deionized water are used instead. Due to the absence of β-glucan and α-glucan oligosaccharide, the aerosol has limited effect on scalp nutrition of beneficial bacteria, and the scalp microecological repair is slow.

[0060] Comparative Example 4

[0061] The difference from Example 1 is that the ingredients do not contain Chuanxiong extract, but 0.5 parts of deionized water. Due to the absence of Chuanxiong extract, the aerosol is affected in promoting scalp blood circulation, nourishing hair, and relieving scalp itching.

[0062] Comparative Example 5

[0063] The difference from Example 1 is that capryloyl glycine is not used in step S1. Aerosol has a certain effect on antibacterial property and regulating sebum secretion.

[0064] Comparative Example 6

[0065] The difference from Example 1 is that sodium L-pyrrolidonecarboxylate is not added to the formula. Aerosol has a greater effect on scalp moisturizing.

[0066] Comparative Example 7

[0067] The difference from Example 1 is that chamomile extract is not added in the formula, and 0.05 parts of deionized water is used instead. The effect of aerosol in nourishing beneficial bacteria on the scalp is limited, and the relief of skin inflammation is affected.

[0068] Aerosol trial effect verification:

[0069] 30 subjects with suspected scalp inflammation and microecological imbalance were screened for a trial to verify the effect of the aerosol. The conditions of the 30 subjects were as follows:

[0070] 10 people had more scales on their scalp and scalp itching (numbered SU01-SU10);

[0071] 10 patients had oily seborrheic alopecia on their scalp (numbered SU11-SU20);

[0072] Ten patients had erythematous plaque inflammation on the scalp (numbered SU21-SU30).

[0073] Thirty subjects were divided into 10 groups, with 3 subjects in each group, and each group had subjects with different symptoms; the aerosol sprays of Examples 1-3 and Comparative Examples 1-7 were used separately for each group. Usage method: Use it once in the morning and once in the evening every day. When using, press the nozzle and spray on the scalp for 3-5 seconds, spray 3 times until the scalp is completely wet, and then gently massage the scalp.

[0074] I. Determination of transepidermal water loss (TEWL):

[0075] Transepidermal water loss (TEWL) is an important parameter for evaluating the skin barrier function, with the unit of g / m 2 / h. The TEWL value represents the amount of water lost per hour per square meter from the deep dermis through the epidermis. The higher the TEWL value, the weaker the barrier function of the scalp cutin layer, the higher the sensitivity, and the more water lost through the skin. The lower the TEWL value, the better the scalp barrier function and the stronger the water retention ability.

[0076] The INFINITY TEWL-2 type transepidermal water loss measuring instrument was used to measure the TEWL value. In an environment of 32°C, the probe was vertically placed on the scalp of the subject, and the average value was taken at 5 different points. The initial TEWL values of 30 subjects were detected and recorded, and the TEWL value was measured again on the 28th day after continuous use of the aerosol spray. The test results are shown in Table 1. By the degree of decrease in the TEWL value before and after using the aerosol spray, the repair effect of the aerosol spray on the scalp microecological barrier can be evaluated. The more the TEWL value decreases, the better the scalp repair effect.

[0077] Table 1 Changes in TEWL values of subjects before and after using the aerosol spray

[0078]

[0079]

[0080] Through the test of the change in the TEWL value of the subjects before and after using the aerosol spray, the TEWL value of the repaired scalp decreased, indicating that the scalp cutin layer barrier was repaired and the water loss decreased. Therefore, the aerosol spray composed of various compositions of the present invention has the effects of moisturizing, nourishing the scalp, promoting scalp blood circulation, antibacterial, and anti-inflammatory, and the microfilm barrier has a good repair effect on the scalp microecology.

[0081] In particular, through the comparison of the usage effects of Examples 1-3 and Comparative Examples 1-7, it was found that the TEWL value of the present invention decreased most significantly only when various combinations worked in synergy. The TEWL value of the repaired scalp in Examples 1-3 decreased by more than 10%, and the repair effect was obvious.

[0082] II. Comprehensive evaluation of the usage effect of the aerosol spray:

[0083] 30 subjects were followed up at the 7th day and 28th day time points during continuous use of the aerosol. The follow-up records were comprehensively scored according to dandruff symptoms, itching symptoms, hair loss symptoms, greasiness symptoms, redness and swelling symptoms, moisture conditions, etc. The scoring criteria are as follows:

[0084] Dandruff symptoms: 5 points represent no dandruff; 3 points represent slight dandruff on the scalp; 1 point represents moderate dandruff on the scalp; 0 points represent a large amount of dandruff on the scalp.

[0085] Itching symptoms: 5 points represent no itching on the scalp; 3 points represent slight itching on the scalp; 1 point represents moderate itching on the scalp; 0 points represent severe itching on the scalp.

[0086] Hair loss symptoms: 5 points represent no hair loss; 3 points represent slight hair loss; 1 point represents moderate hair loss; 0 points represent severe hair loss on the scalp.

[0087] Greasiness symptoms: 5 points represent no greasiness on the scalp; 3 points represent slight greasiness of the scalp and hair; 1 point represents moderate greasiness of the scalp and hair; 0 points represent severe greasiness of the scalp and hair.

[0088] Redness and swelling symptoms: 5 points represent no redness and swelling on the scalp; 3 points represent slight redness and swelling on the scalp; 1 point represents moderate redness and swelling on the scalp; 0 points represent severe redness and swelling on the scalp.

[0089] Moisture conditions: 5 points represent a moist and refreshing scalp without allergy; 3 points represent normal scalp moisture; 1 point represents slightly dry scalp; 0 points represent relatively dry scalp.

[0090] The comprehensive scores of the usage effects at different trial time points during the follow-up are shown in Table 2. The higher the comprehensive score, the better the comprehensive effects of the aerosol in anti-dandruff, anti-itching, oil inhibition, anti-inflammation, etc., and the more obvious the effect of scalp microecological repair.

[0091] Table 2 Comprehensive Score Table of the Effects of the Aerosol Used by the Subjects

[0092]

[0093]

[0094] Through the comprehensive evaluation and analysis of the feedback from the subjects after using Examples 1-3 and Comparative Examples 1-7, the trial effects of the samples of Examples 1-3 of the present invention are generally good, and they are excellent in aspects such as repairing the scalp microecology, constructing a mild scalp barrier, inhibiting dandruff, and inhibiting inflammation.

[0095] The applicant declares that the preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, the equivalent substitution of various raw materials of the present invention and the addition of auxiliary components, etc., all fall within the protection scope and the disclosure scope of the present invention.

Claims

1. A scalp microecological repair aerosol, characterized by It comprises a scalp microecological repair composition and a propellant; wherein: The scalp microecological repair composition comprises the following raw material components by weight: 5-10 parts of emulsified castor oil, 1-2 parts of sodium L-pyrrolidonecarboxylate, 0.5-1.0 parts of Chuanxiong extract, 0.5-1.0 parts of tea seed oil, 0.3-0.5 parts of composite microfilm auxiliary agent, 0.1-0.2 parts of sodium hyaluronate, 0.1-0.2 parts of β-glucan, 0.1-0.2 parts of α-glucan oligosaccharide, 0.05-0.1 parts of isopropyl myristate, and 0.05-0.1 parts of DL-panthenol. , 0.05-0.1 parts of chamomile extract, 0.05-0.1 parts of emulsifier, 0.01-0.05 parts of phospholipids, 0.01-0.03 parts of capryloyl glycine, 0.005-0.01 parts of 2-α-glycerol glucoside, 85-90 parts of deionized water, an appropriate amount of flavoring agent, and an appropriate amount of pH regulator; the composite micro-film auxiliary agent is an emulsion of polyethylene glycol and frankincense ground; the pH regulator is lactic acid, which is added in an appropriate amount to adjust the pH value of the scalp microecological repair composition to 4.5-5.8; The propellant is one of liquefied petroleum gas (LPG), dimethyl ether (DME), carbon dioxide (CO2), nitrogen, 1,1-difluoroethane (HFC-152a), and 1,1,1,2-tetrafluoroethane (HFC-134a); the amount of the propellant is 35-45% of the total weight of the scalp microecological repair composition.

2. The scalp microecological repair aerosol according to claim 1, characterized in that: The emulsified castor oil is prepared by mixing a composite emulsifier, castor oil and water in a mass ratio of 1:(7-8):(7-10), and emulsifying in a homogenizer at 45-50° C. and a rotation speed of 2000-3000 r / min for 10-15 minutes; the composite emulsifier is prepared by compounding Span 80 and Tween 60 in a mass ratio of 3:

7.

3. The scalp microecological repair aerosol according to claim 1, characterized in that: The composite micro-film auxiliary agent is an emulsion formed by grinding polyethylene glycol and frankincense in a mass ratio of 3-5:

1.

4. The scalp microecological repair aerosol according to claim 1, characterized in that: The molecular weight of the sodium hyaluronate is 1.0×10 4 -1.0×10 6 Da.

5. The scalp microecological repair aerosol according to claim 1, characterized in that: The emulsifier is selected from at least one of Tween-20, Tween-40, Tween-60 and Tween-80.

6. The scalp microecological repair aerosol according to claim 1, characterized in that: The phospholipid is selected from at least one of phosphatidylglycerol, phosphatidylserine, phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol.

7. The scalp microecological repair aerosol according to claim 1, characterized in that: The flavoring agent is selected from one or more of menthol, rose ketone, lavender essential oil, jasmine essential oil, rosemary essential oil, lily essence, lemon essence, aloe essence, milk essence, and grass essence as needed.

8. The scalp microecological repair aerosol according to claim 1, characterized in that: The pH regulator is lactic acid to adjust the pH value of the scalp microecological repair composition to 5.

5.

9. A method for preparing the scalp microecological repair aerosol according to any one of claims 1 to 8, characterized in that: The specific preparation method is as follows: S1. Dissolve 0.05-0.1 parts of isopropyl myristate, 0.01-0.05 parts of phospholipids, and 0.01-0.03 parts of capryloyl glycine in 0.5-1.0 parts of tea seed oil to form an oil phase; add 0.05-0.1 parts of emulsifier to the oil phase and stir at a low speed of 100-150r / min for 10-20min to form a premix; add 3-5 parts of deionized water to a stainless steel emulsifying tank, stir at a high speed of 5000-12000r / min, disperse the premix into the deionized water continuous phase, and control the stirring time to 20-35min to obtain a pre-emulsion; S2. According to the weight ratio, add 82-85 parts of deionized water to the mixing tank, stir at a low speed, then slowly add the pre-emulsion prepared in step S1 and 0.3-0.5 parts of the composite micro-film additive to the mixing tank and stir at a low speed for 3-5 minutes to mix evenly, further add 5-10 parts of emulsified castor oil, 1-2 parts of sodium L-pyrrolidonecarboxylate, 0.5-1.0 parts of Chuanxiong extract, 0.1-0.2 parts of sodium hyaluronate, 0.1-0.2 parts of β-glucan -0.2 parts, α-glucan oligosaccharide 0.1-0.2 parts, DL-panthenol 0.05-0.1 parts, chamomile extract 0.05-0.1 parts, 2-α-glycerol glucoside 0.005-0.01 parts, and an appropriate amount of a flavoring agent are stirred and mixed at a low speed, the pH value is checked, and then lactic acid as a pH regulator is added to adjust the pH value to 4.8-5.8; the material is filtered through a 200-mesh stainless steel filter to obtain a scalp microecological repair composition; S3. The scalp microecological repair composition obtained in step S2 is canned at normal pressure using a tinplate can as a container, the valve is sealed, and a propellant is charged, wherein the amount of the propellant charged is 35-45% of the total weight of the scalp microecological repair composition, and weighing and water bath testing are performed, and a nozzle is installed to obtain a scalp microecological repair aerosol.

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