Nutritional composition for rapidly and uniformly supplementing nutrition for delivery of pregnant women and preparation method thereof

Abstract

The invention provides a nutritional composition for quickly and uniformly supplementing nutrition for delivery of pregnant women and a preparation method of the nutritional composition. The invention provides a nutritional composition. The nutritional composition comprises maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, mineral substances, vitamins and salt. The invention further provides a preparation method and application of the nutritional composition, a composition or a kit containing the nutritional composition, a non-treatment method and the like.

Description

Technical Field

[0001] The invention belongs to the field of food, and more specifically, relates to a nutritional composition for quickly and evenly supplementing nutrition for pregnant women during childbirth and a preparation method thereof. Background Art

[0002] The childbirth process requires specific energy and nutrients. During the childbirth process, the pregnant woman's body undergoes drastic physiological changes, which place special demands on the demand for specific nutrients. For example, uterine smooth muscle and contractile muscle mainly use glucose for energy metabolism during childbirth, and stress reactions such as pain and muscle tension stimulate catecholamines, cortisol and the sympathetic nervous system to increase the production of endogenous glucose to meet the body's energy needs. In addition, specific proteins, vitamins and minerals are also required during childbirth, such as protein, which is essential for muscle recovery and milk production, and minerals such as calcium, iron and folic acid are equally important for maternal and child health. Therefore, a nutritional composition is needed that can provide these specific nutrients to meet the special needs during childbirth.

[0003] The process of childbirth is a high energy consumption process, which is equivalent to moderate-intensity aerobic exercise. Studies have shown that the energy consumption during childbirth is approximately equivalent to that of continuous moderate-intensity aerobic exercise, and this level of energy consumption is comparable to that of high-intensity exercise. For example, Eliasson et al. reported that a 9-hour labor process consumes approximately 692 kcal of energy, while Hagerdal et al. showed that the energy consumption during the inter-contraction period and the contraction period in the first stage of labor was approximately 67 kcal / h, and the energy consumption during the contraction period was 109 kcal / h; while the energy consumption in the second stage of labor was approximately 140 kcal / h. This level of energy consumption is comparable to that of high-intensity exercise, so additional nutrients are needed during childbirth to support this high energy demand.

[0004] Nutrient supplementation during the delivery process needs to be able to bring about improvements in relevant clinical outcome indicators. The nutritional composition used by pregnant women during delivery should not only meet the needs of energy and nutrients, but also help improve clinical outcome indicators, such as shortening the labor process, increasing the rate of normal delivery, and reducing the incidence of complications during delivery. Lack of energy during delivery can lead to weak contraction of uterine smooth muscle, prolonged labor, and may even increase the rate of low forceps and cesarean section. Therefore, reasonable nutritional supplementation can effectively improve the outcome of delivery, such as by providing sufficient energy and nutrients to enhance the physical strength of pregnant women and reduce the risk of insufficient labor, or by supplementing specific minerals and vitamins to promote cervical dilation and reduce labor bleeding. Summary of the invention

[0005] The object of the present invention is to provide a nutritional composition for rapidly and evenly supplementing nutrition for pregnant women during childbirth and a preparation method thereof.

[0006] In a first aspect of the present invention, a nutritional composition is provided, comprising: maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salt.

[0007] In one or more embodiments, the nutritional composition comprises:

[0008] 26 to 35 parts by weight of maltodextrin, preferably 28 to 32 parts by weight of maltodextrin,

[0009] 17 to 23 parts by weight of protein powder, preferably 19 to 22 parts by weight of protein powder,

[0010] 15 to 23 parts by weight of glucose, preferably 18 to 22 parts by weight of glucose,

[0011] 5 to 15 parts by weight of triglyceride powder, preferably 8 to 12 parts by weight of triglyceride powder,

[0012] 2 to 8 parts by weight of fruit powder, preferably 5 to 8 parts by weight of fruit powder,

[0013] 2 to 8 parts by weight of fructose, preferably 3 to 7 parts by weight of fructose,

[0014] 2 to 8 parts by weight of minerals, preferably 4 to 7 parts by weight of minerals,

[0015] 0.1 to 2 parts by weight of vitamins, preferably 0.5 to 1.5 parts by weight of vitamins,

[0016] 0.5 to 2 parts by weight of the salt, preferably 0.5 to 1.6 parts by weight of the salt.

[0017] In one or more embodiments, the mineral comprises calcium lactate (eg, calcium L-lactate), magnesium sulfate, ferrous gluconate, zinc gluconate, or a combination thereof.

[0018] In one or more embodiments, the minerals include: 3-5 parts by weight of calcium lactate (eg, L-calcium lactate), 1-2 parts by weight of magnesium sulfate, 0.1-0.3 parts by weight of ferrous gluconate, and 0.02-0.08 parts by weight of zinc gluconate.

[0019] In one or more embodiments, the minerals include: 3.15-4.51 parts by weight of calcium lactate (eg, L-calcium lactate), 1.08-1.65 parts by weight of magnesium sulfate, 0.149-0.220 parts by weight of ferrous gluconate, and 0.043-0.063 parts by weight of zinc gluconate.

[0020] In one or more embodiments, the vitamins include: vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, pantothenic acid, folic acid, or a combination thereof.

[0021] In one or more embodiments, the vitamins include: 0.005-0.01 parts by weight of vitamin A, 0.001-0.005 parts by weight of vitamin D, 0.01-0.05 parts by weight of vitamin E, 0.001-0.005 parts by weight of vitamin B1, 0.01-0.05 parts by weight of vitamin B2, 0.05-0.1 parts by weight of vitamin B6, 0.001-0.006 parts by weight of vitamin B12, 0.1-0.3 parts by weight of vitamin C, 0.01-0.03 parts by weight of niacin, 0.005-0.01 parts by weight of pantothenic acid, and 0.001-0.01 parts by weight of folic acid.

[0022] In one or more embodiments, the vitamins include: 0.0056-0.0085 parts by weight of vitamin A, 0.0030-0.0046 parts by weight of vitamin D, 0.019-0.029 parts by weight of vitamin E, 0.0023-0.0034 parts by weight of vitamin B1, 0.023-0.034 parts by weight of vitamin B2, 0.060-0.090 parts by weight of vitamin B6, 0.0035-0.0052 parts by weight of vitamin B12, 0.134-0.202 parts by weight of vitamin C, 0.013-0.020 parts by weight of niacin, 0.0065-0.0096 parts by weight of pantothenic acid, and 0.004-0.006 parts by weight of folic acid.

[0023] In one or more embodiments, the nutritional composition further comprises one or more of the following features:

[0024] (1) The protein powder comprises: whey protein powder, soy protein isolate powder or cod collagen powder, or a combination thereof; preferably, the protein powder is whey protein powder;

[0025] (2) The glucose is anhydrous glucose;

[0026] (3) The fructose is crystalline fructose;

[0027] (4) The triglyceride powder contains medium-chain triglycerides, preferably the triglyceride powder contains at least 30% by weight of medium-chain triglycerides, more preferably at least 50% by weight of medium-chain triglycerides, and more preferably at least 70% by weight of medium-chain triglycerides;

[0028] (5) The salt is a potassium salt, an edible salt or a combination thereof, preferably potassium citrate and edible salt, more preferably 0.5 to 1 parts by weight of potassium citrate and 0.5 to 1 parts by weight of edible salt;

[0029] (6) The fruit powder is blueberry fruit powder.

[0030] In one or more embodiments, the nutritional composition consists of the following ingredients:

[0031] 26 to 35 parts by weight of maltodextrin, preferably 28 to 32 parts by weight of maltodextrin,

[0032] 17 to 23 parts by weight of protein powder, preferably 19 to 22 parts by weight of protein powder,

[0033] 15 to 23 parts by weight of glucose, preferably 18 to 22 parts by weight of glucose,

[0034] 5 to 15 parts by weight of triglyceride powder, preferably 8 to 12 parts by weight of triglyceride powder,

[0035] 2 to 8 parts by weight of blueberry powder, preferably 5 to 8 parts by weight of blueberry powder,

[0036] 2 to 8 parts by weight of crystalline fructose, preferably 3 to 7 parts by weight of crystalline fructose,

[0037] 2 to 8 parts by weight of minerals, preferably 4 to 7 parts by weight of minerals,

[0038] 0.1 to 2 parts by weight of vitamins, preferably 0.5 to 1.5 parts by weight of vitamins,

[0039] 0.5 to 1 parts by weight of potassium citrate, and

[0040] 0.5 to 1 parts by weight of edible salt.

[0041] In one or more embodiments, the minerals include: 3 to 5 parts by weight of calcium lactate (e.g., L-calcium lactate), 1 to 2 parts by weight of magnesium sulfate, 0.1 to 0.3 parts by weight of ferrous gluconate, and 0.02 to 0.08 parts by weight of zinc gluconate, and / or the vitamins include: 0.005 to 0.01 parts by weight of vitamin A, 0.001 to 0.005 parts by weight of vitamin D, 0.01 to 0.05 parts by weight of Vitamin E, 0.001-0.005 weight part of vitamin B1, 0.01-0.05 weight part of vitamin B2, 0.05-0.1 weight part of vitamin B6, 0.001-0.006 weight part of vitamin B12, 0.1-0.3 weight part of vitamin C, 0.01-0.03 weight part of niacin, 0.005-0.01 weight part of pantothenic acid and 0.001-0.01 weight part of folic acid.

[0042] A second aspect of the present invention provides a method for preparing a nutritional composition, the method comprising: mixing maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salt to obtain a total mixture.

[0043] In one or more embodiments, the preparation method comprises:

[0044] 1) mixing calcium lactate (e.g., L-calcium lactate), magnesium sulfate, ferrous gluconate, and zinc gluconate to form a mineral mixture,

[0045] 2) mixing vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, pantothenic acid and folic acid to form a vitamin mixture, and

[0046] 3) The mineral mixture obtained in 1) and the vitamin mixture obtained in 2) are mixed with maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose and salt to obtain a total mixture.

[0047] In one or more embodiments, the nutritional composition is the nutritional composition described in any embodiment of the present invention.

[0048] The third aspect of the present invention provides the nutritional composition described in any embodiment of the present invention, or the nutritional composition prepared by the preparation method described in any embodiment of the present invention, in an application selected from the following aspects:

[0049] (A) Use in the preparation of a composition or a kit for providing nutrition to pregnant women;

[0050] (B) Use in the preparation of a composition or kit that can quickly supply energy to pregnant women, shorten the delivery process of pregnant women, reduce the amount of bleeding during delivery, and / or alleviate the gastrointestinal reaction of pregnant women.

[0051] In one or more embodiments, the pregnant women include pregnant women who are about to give birth, pregnant women in labor, and women who have just given birth. Preferably, the pregnant women are pregnant women in labor.

[0052] In one or more embodiments, the pregnant woman includes a pregnant woman who is expecting a baby and a pregnant woman in labor, and preferably the pregnant woman is a pregnant woman in labor.

[0053] In one or more embodiments, the rapid energy supply includes: a rapid increase in ATP levels, a rapid increase in exercise capacity and endurance.

[0054] In one or more embodiments, shortening the delivery process of the pregnant woman includes: shortening the first stage of labor, the second stage of labor, the third stage of labor and / or the total stage of labor of the pregnant woman, preferably shortening the first stage of labor and the total stage of labor of the pregnant woman.

[0055] In one or more embodiments, reducing the amount of bleeding during labor in pregnant women includes: reducing the amount of bleeding during labor in pregnant women to less than 250 mL, preferably less than 245 mL.

[0056] In one or more embodiments, the gastrointestinal reactions include: nausea, vomiting.

[0057] A fourth aspect of the present invention provides a composition or a kit, wherein the composition or the kit contains an effective amount of the nutritional composition described in any embodiment of the present invention.

[0058] In one or more embodiments, the effective amount of the nutritional composition is 100-2000 μg / mL, preferably 125-500 μg / mL or 250-500 μg / mL.

[0059] In one or more embodiments, the composition or kit further comprises a pharmaceutically, nutraceutically, nutritionally or food-acceptable carrier.

[0060] In one or more embodiments, the kit is a packaged bottle.

[0061] The fifth aspect of the present invention provides a non-therapeutic method for providing nutrition to pregnant women, and / or quickly supplying energy to pregnant women, shortening the delivery process of pregnant women, reducing the amount of bleeding during delivery, and / or alleviating gastrointestinal reactions in pregnant women, the method comprising: providing the pregnant woman with an effective amount of the nutritional composition described in any embodiment of the present invention or the nutritional composition prepared by the preparation method described in any embodiment of the present invention, or providing the pregnant woman with the composition or kit described in any embodiment of the present invention.

[0062] In one or more embodiments, the effective amount of the nutritional composition is 100-2000 μg / mL, preferably 125-500 μg / mL or 250-500 μg / mL.

[0063] In one or more embodiments, the pregnant women include pregnant women who are about to give birth, pregnant women in labor, and women who have just given birth. Preferably, the pregnant women are pregnant women in labor.

[0064] In one or more embodiments, the pregnant woman includes a pregnant woman who is expecting a baby and a pregnant woman in labor, and preferably the pregnant woman is a pregnant woman in labor.

[0065] In one or more embodiments, the rapid energy supply includes: a rapid increase in ATP levels, a rapid increase in exercise capacity and endurance.

[0066] In one or more embodiments, shortening the delivery process of the pregnant woman includes: shortening the first stage of labor, the second stage of labor, the third stage of labor and / or the total stage of labor of the pregnant woman, preferably shortening the first stage of labor and the total stage of labor of the pregnant woman.

[0067] In one or more embodiments, reducing the amount of bleeding during labor in pregnant women includes: reducing the amount of bleeding during labor in pregnant women to less than 250 mL, preferably less than 245 mL.

[0068] In one or more embodiments, the gastrointestinal reactions include: nausea, vomiting.

[0069] Other aspects of the present invention will be apparent to those skilled in the art in view of the disclosure herein. BRIEF DESCRIPTION OF THE DRAWINGS

[0070] Figure 1 , The typical movement trajectory of zebrafish after being treated with the normal control group, model control group, 20.8μL / mL Red Bull group, 125μg / mL, 250μg / mL or 500μg / mL nutritional composition of the present invention by a behavior analyzer. The black line is the slow movement distance, the green line is the medium speed movement distance, and the red line is the fast movement distance.

[0071] Figure 2 , normal control group, model control group, 20.8 μL / mL Red Bull group, 125 μg / mL, 250 μg / mL or 500 μg / mL nutritional composition group of the present invention. Compared with the model control group, ** indicates p<0.01, *** indicates p<0.001. DETAILED DESCRIPTION

[0072] After in-depth research, the inventors have provided a nutritional composition for rapid and balanced nutritional supplementation for pregnant women during childbirth and a preparation method thereof. The nutritional composition has a rapid energy supply effect that is superior to Red Bull, and can increase the total movement distance and ATP content of zebrafish. At the same time, the nutritional composition can significantly increase the cervical dilation speed of pregnant women, effectively shorten the delivery process, and reduce the amount of bleeding during delivery.

[0073] the term

[0074] As used herein, the term "nutritional composition" or "nutritional composition" includes dietary supplements, health care product compositions (compositions), food additive compositions (compositions), etc., as long as they contain effective amounts of maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salts as described in the present invention as the main active ingredients for nutritional supplementation.

[0075] As used herein, the terms "comprising" or "including" include "comprising," "consisting essentially of, and "consisting of.

[0076] As used herein, the term "consisting essentially of..." means that in addition to the essential ingredients or components, the nutritional composition may also contain a small amount of minor ingredients and / or impurities that do not affect the effective ingredients. For example, it may contain sweeteners or flavoring agents to improve the taste, antioxidants to prevent oxidation, and other additives commonly used in the art.

[0077] As used herein, "parts by weight" or "parts by weight" are used interchangeably, and the parts by weight may be any fixed weight expressed in milligrams, grams or kilograms (such as 1 mg, 1 g, 2 g, 5 g, or 1 kg, etc.). For example, a composition consisting of 1 part by weight of component a and 9 parts by weight of component b may be a composition consisting of 1 gram of component a + 9 grams of component b, or 10 grams of component a + 90 grams of component b, etc. In the composition, the percentage content of a component = (parts by weight of the component / sum of the parts by weight of all components) × 100%. Therefore, in a composition consisting of 1 part by weight of component a and 9 parts by weight of component b, the content of component a is 10%, and that of component b is 90%.

[0078] As used herein, the terms "at least", "at most", "above", "below", "lower", and "higher" all include the number. For example, "at least 30% by weight" means greater than or equal to 30% by weight.

[0079] Nutritional composition

[0080] The invention provides a nutritional composition, which comprises maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salt.

[0081] In some embodiments, the nutritional composition comprises:

[0082] 26 to 35 parts by weight of maltodextrin, preferably 28 to 32 parts by weight of maltodextrin,

[0083] 17 to 23 parts by weight of protein powder, preferably 19 to 22 parts by weight of protein powder,

[0084] 15 to 23 parts by weight of glucose, preferably 18 to 22 parts by weight of glucose,

[0085] 5 to 15 parts by weight of triglyceride powder, preferably 8 to 12 parts by weight of triglyceride powder,

[0086] 2 to 8 parts by weight of fruit powder, preferably 5 to 8 parts by weight of fruit powder,

[0087] 2 to 8 parts by weight of fructose, preferably 3 to 7 parts by weight of fructose,

[0088] 2 to 8 parts by weight of minerals, preferably 4 to 7 parts by weight of minerals,

[0089] 0.1 to 2 parts by weight of vitamins, preferably 0.5 to 1.5 parts by weight of vitamins,

[0090] 0.5 to 2 parts by weight of the salt, preferably 0.5 to 1.6 parts by weight of the salt.

[0091] In some embodiments, the protein powder includes: whey protein powder, soy protein isolate powder or cod collagen powder, or a combination thereof (eg, including at least 2 or all 3 thereof); preferably, the protein powder is whey protein powder.

[0092] In some embodiments, the glucose is anhydrous glucose.

[0093] In some embodiments, the fructose is crystalline fructose.

[0094] In some embodiments, the triglyceride powder comprises medium-chain triglycerides. In some embodiments, the triglyceride powder comprises at least 30% by weight of medium-chain triglycerides, preferably at least 50% by weight of medium-chain triglycerides, and more preferably at least 70% by weight of medium-chain triglycerides. The medium chain generally refers to a carbon chain length of 6 to 12 carbon atoms. In the fatty acid composition of the medium-chain triglycerides, three fatty acids are medium-chain fatty acids.

[0095] In some embodiments, the minerals include: calcium lactate (e.g., L-calcium lactate), magnesium sulfate, ferrous gluconate, zinc gluconate, or a combination thereof (e.g., including at least 2, 3, or 4 thereof). In some embodiments, the minerals include: 3 to 5 parts by weight of calcium lactate (e.g., L-calcium lactate), 1 to 2 parts by weight of magnesium sulfate, 0.1 to 0.3 parts by weight of ferrous gluconate, and 0.02 to 0.08 parts by weight of zinc gluconate. In some preferred embodiments, the minerals include: 3.15 to 4.51 parts by weight of calcium lactate (e.g., L-calcium lactate), 1.08 to 1.65 parts by weight of magnesium sulfate, 0.149 to 0.220 parts by weight of ferrous gluconate, and 0.043 to 0.063 parts by weight of zinc gluconate.

[0096] In some embodiments, the vitamins include: vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, pantothenic acid, folic acid, or a combination thereof (for example, including at least 5, 6, 7, 8, 9, 10 or 11 thereof). In some embodiments, the vitamins include: 0.005-0.01 parts by weight of vitamin A, 0.001-0.005 parts by weight of vitamin D, 0.01-0.05 parts by weight of vitamin E, 0.001-0.005 parts by weight of vitamin B1, 0.01-0.05 parts by weight of vitamin B2, 0.05-0.1 parts by weight of vitamin B6, 0.001-0.006 parts by weight of vitamin B12, 0.1-0.3 parts by weight of vitamin C, 0.01-0.03 parts by weight of niacin, 0.005-0.01 parts by weight of pantothenic acid, and 0.001-0.01 parts by weight of folic acid. In some preferred embodiments, the vitamins include: 0.0056-0.0085 parts by weight of vitamin A, 0.0030-0.0046 parts by weight of vitamin D, 0.019-0.029 parts by weight of vitamin E, 0.0023-0.0034 parts by weight of vitamin B1, 0.023-0.034 parts by weight of vitamin B2, 0.060-0.090 parts by weight of vitamin B6, 0.0035-0.0052 parts by weight of vitamin B12, 0.134-0.202 parts by weight of vitamin C, 0.013-0.020 parts by weight of niacin, 0.0065-0.0096 parts by weight of pantothenic acid and 0.004-0.006 parts by weight of folic acid.

[0097] In some embodiments, the salt comprises potassium salt, edible salt, or a combination thereof (e.g., comprising at least two thereof); preferably, the salt comprises 0.5 to 1 parts by weight of potassium salt and 0.5 to 1 parts by weight of edible salt; more preferably, the salt comprises 0.5 to 1 parts by weight of potassium citrate and 0.5 to 1 parts by weight of edible salt.

[0098] In some embodiments, the nutritional composition is composed of the following ingredients: 26-35 parts by weight (preferably 28-32 parts by weight) of maltodextrin, 17-23 parts by weight (preferably 19-22 parts by weight) of whey protein powder, 15-23 parts by weight (preferably 18-22 parts by weight) of anhydrous glucose, 5-15 parts by weight (preferably 8-12 parts by weight) of triglyceride powder, 2-8 parts by weight (preferably 5-8 parts by weight) of blueberry fruit powder, 2-8 parts by weight (preferably 3-7 parts by weight) of crystalline fructose, 2-8 parts by weight (preferably 4-7 parts by weight) of minerals, and 0.1-2 parts by weight (preferably 0.1-2 parts by weight) of sucrose. Preferably, the minerals include: 3-5 parts by weight (preferably 3.15-4.51 parts by weight) of calcium lactate (e.g. L-calcium lactate), 1-2 parts by weight (preferably 1.08-1.65 parts by weight) of magnesium sulfate, 0.1-0.3 parts by weight (preferably 0.149-0.220 parts by weight) of ferrous gluconate and 0.02-0.08 parts by weight (preferably 0.043-0.063 parts by weight) of zinc gluconate, and / or the vitamins include: 0. 0.005-0.01 weight part (preferably 0.0056-0.0085 weight part) of vitamin A, 0.001-0.005 weight part (preferably 0.0030-0.0046 weight part) of vitamin D, 0.01-0.05 weight part (preferably 0.019-0.029 weight part) of vitamin E, 0.001-0.005 weight part (preferably 0.0023-0.0034 weight part) of vitamin B1, 0.01-0.05 weight part (preferably 0.023-0.034 weight part) of vitamin B2, 0.05-0.1 weight part (preferably 0.006-0.014 weight part) of vitamin B3, 0.001-0.01 weight part (preferably 0.006-0.014 weight part) of vitamin B4, 0.001-0.01 weight part (preferably 0.006-0.014 weight part) of vitamin B5, 0.001-0.01 weight part (preferably 0.006-0.014 weight part) of vitamin B6, 0.001-0.01 weight part (preferably 0.006-0.014 weight part) of vitamin B7, 0.001-0.01 weight part (preferably 0.006-0.014 weight part) of vitamin B8, 0.001-0.01 weight part (preferably 0.001 Preferably, the composition comprises 0.060-0.090 weight part) of vitamin B6, 0.001-0.006 weight part (preferably 0.0035-0.0052 weight part) of vitamin B12, 0.1-0.3 weight part (preferably 0.134-0.202 weight part) of vitamin C, 0.01-0.03 weight part (preferably 0.013-0.020 weight part) of niacin, 0.005-0.01 weight part (preferably 0.0065-0.0096 weight part) of pantothenic acid and 0.001-0.01 weight part (preferably 0.004-0.006 weight part) of folic acid.

[0099] In the nutritional composition, the components for supplying energy include: maltodextrin, glucose, fructose, fruit powder, triglyceride powder and protein powder. Since the time for digestion and absorption of these components in the body is different, energy can be supplied in stages, and the energy and nutrients required during childbirth are provided to pregnant women in an orderly and rapid manner. In the nutritional composition, the glucose contained in glucose and maltodextrin is the fastest digestion and absorption speed, and can be used as an energy supplier for the first stage. After the glycogen and glucose stored in the body, especially in the uterine smooth muscle and the contraction machine, are consumed, the monosaccharides and disaccharides in fructose and fruit powder (such as blueberry fruit powder), and the non-glucose components contained in triglycerides and maltodextrin can be quickly decomposed into glucose through pathways such as gluconeogenesis, as an energy supplier for the second stage. Finally, the digestion and absorption time of protein powder in the body is about 2h, which can be used as an energy supplier for the third stage.

[0100] In the nutritional composition, the components for providing electrolytes include: salt, minerals (L-calcium lactate, magnesium sulfate, ferrous gluconate and zinc gluconate). In the nutritional composition, the content of salt and minerals as electrolytes is generally 4.5 to 8.6 parts by weight, for example 7 to 8 parts by weight, and the electrolyte component content is relatively high. The inventors found that pregnant women have different requirements for electrolytes than ordinary people. The optimized electrolyte components in the nutritional composition effectively provide sodium, potassium, chlorine and calcium for pregnant women during childbirth, maintain neuromuscular function, and avoid the occurrence of myasthenia or hyponatremia. Iron is an important component of transferrin, and the ferrous gluconate in the nutritional composition can provide sufficient oxygen for the body's energy metabolism and excrete the generated carbon dioxide. Zinc is a component and enzymatic factor of various enzymes in various organisms, and the zinc gluconate in the nutritional composition can effectively affect the activity of respiratory enzymes in the body's energy metabolism.

[0101] The addition of multiple vitamins in the nutritional composition meets the needs of pregnant women for energy metabolism. Vitamin B1 can participate in the sugar metabolism process in the body in the form of thiamine pyrophosphate; vitamin B2 participates in the biological oxidation energy supply process in the form of flavin mononucleotide and flavin adenine dinucleotide as a coenzyme in the body; niacin is converted into nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate in the body, participating in energy metabolism pathways such as glycolysis, tricarboxylic acid cycle and respiratory chain in the body; pantothenic acid, as a component of coenzyme A in the body, plays a key role in the metabolism of sugar, fat and protein; vitamin B6 participates in amino acid metabolism in the form of pyridoxal phosphate and pyridoxamine phosphate in the body. Although it does not directly participate in the main pathway of energy metabolism, it indirectly affects energy metabolism by regulating protein metabolism; folic acid and vitamin B12 play a key role in the metabolism and transport of one-carbon units. One-carbon units participate in the synthesis of purines and pyrimidines, affecting cell proliferation and metabolism, such as megaloblasts, which can affect the body's ability to transport oxygen; vitamin A, vitamin D, vitamin C, vitamin E, etc., although not directly involved in the main pathway of intracellular energy metabolism, can protect the integrity of cells.

[0102] In the nutritional composition, the fruit powder, especially the blueberry fruit powder, can not only be used as an energy supply component, but also has a refreshing taste, which is beneficial to promoting appetite and reducing the emotional reactions of pregnant women such as emotional tension and pain at the beginning of the cervix.

[0103] Application / Method

[0104] The present invention provides the use of the nutritional composition, which is used for preparing a composition or a kit for providing nutrition to pregnant women.

[0105] The present invention also provides a method for providing nutrition to a pregnant woman in a non-therapeutic manner, the method comprising providing an effective amount of the nutritional composition according to any embodiment of the present invention to the pregnant woman.

[0106] In some embodiments, the pregnant women include pregnant women who are about to give birth, pregnant women in labor, and women who have just given birth. Preferably, the pregnant women are pregnant women in labor.

[0107] In some embodiments, the pregnant women include expectant mothers and pregnant women in labor, and preferably the pregnant women are pregnant women in labor.

[0108] As used herein, the term "effective amount" refers to an amount that can produce a function or activity on humans and / or animals and can be accepted by humans and / or animals. In some embodiments, the effective amount of the nutritional composition is 100-2000 μg / mL, preferably 125-500 μg / mL or 250-500 μg / mL.

[0109] In the present invention, the nutritional composition may also contain a pharmaceutically, nutraceutically or food-acceptable carrier. As used herein, the term "pharmaceutically acceptable", "nutraceutically acceptable", "nutritionally acceptable" or "food-acceptable" ingredients are suitable for humans and / or animals without excessive adverse side effects (such as toxicity, irritation and allergic reactions), that is, substances with a reasonable benefit / risk ratio.

[0110] As used herein, the term "pharmaceutically, nutraceutically, nutritionally or food-acceptable carrier" refers to a carrier used to deliver the active ingredients (effective ingredients) of the nutritional composition of the present invention into the body, including various excipients and diluents. The term refers to carriers that are not necessary active ingredients themselves and are not overly toxic after administration. Suitable carriers are well known to those of ordinary skill in the art. Auxiliary substances such as fillers, disintegrants, lubricants, glidants, effervescent agents, wetting agents or emulsifiers, flavoring agents, antioxidants, pH buffer substances, etc. may be present in these carriers.

[0111] As used herein, the term "nutritional composition" includes: health care product compositions, food compositions and / or dietary additive compositions, as long as they contain or are substantially composed of the maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salts of the present invention (preferably containing or substantially composed of the maltodextrin, whey protein powder, anhydrous glucose, triglyceride powder, blueberry fruit powder, crystalline fructose, minerals, vitamins, potassium citrate and edible salt of the present invention). Typically, the weight of maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salts (preferably maltodextrin, whey protein powder, anhydrous glucose, triglyceride powder, blueberry fruit powder, crystalline fructose, minerals, vitamins, potassium citrate and edible salt) accounts for 90-100% of the total weight of the composition, such as 95-99.9%.

[0112] There is no particular limitation on the dosage form of the nutritional composition of the present invention, and it can be any dosage form suitable for mammals to take; the dosage forms that can be prepared include: powders, powders, tablets, pills, capsules, sustained-release agents, controlled-release agents and other solid dosage forms. It can also be other dosage forms such as semi-solid dosage forms. Preferably, the dosage form can be but is not limited to: powders, granules, capsules, tablets, oral liquids, suspensions, or emulsions. In some embodiments, the dosage form of the nutritional composition is a powder. In some embodiments, the nutritional composition of the powder can be added to water or drinks. In some embodiments, in water or drinks, the concentration of the nutritional composition is 100-2000 μg / mL, preferably 125-500 μg / mL or 250-500 μg / mL. In some embodiments, the nutritional composition is ready-to-use and ready-to-mix. Before use, the nutritional composition is added to water or drinks to prepare a solution.

[0113] In some embodiments, the nutritional composition is in a unit dosage form. As used herein, the term "unit dosage form" means that for the convenience of taking, the nutritional composition of the present invention is prepared into a dosage form required for a single dose, including but not limited to various solid doses (such as tablets), liquid doses; for example, but not limited to powders, granules, capsules, tablets, oral liquids, suspensions or emulsions. The unit dosage form contains a nutritional composition of the present invention suitable for a single, single-day or unit time dose. When the nutritional composition is prepared into a unit dosage form, 1-3 doses of the nutritional composition in the unit dosage form are taken; more preferably, 2 doses of the nutritional composition in the unit dosage form are taken every day. In some embodiments, the nutritional composition in the unit dosage form is 50 to 100 g, for example, 50 g.

[0114] The present invention finds that the nutritional composition has a rapid energy supply effect that is superior to Red Bull, and can increase the total movement distance and ATP content of zebrafish. Pregnant women drink the nutritional composition before delivery (during the delivery period) or during the delivery process, which can quickly provide the energy needed by pregnant women during delivery, significantly improve the speed of cervical dilation, effectively avoid the phenomenon of insufficient production force, shorten the delivery process of pregnant women, and reduce the amount of bleeding during delivery. Therefore, the present invention also provides the use of the nutritional composition in the preparation of a composition or a kit that can quickly supply energy to pregnant women in delivery, shorten the delivery process of pregnant women, and / or reduce the amount of bleeding during delivery of pregnant women.

[0115] In some embodiments, the rapid energy supply includes but is not limited to: rapid increase in ATP content, rapid increase in athletic ability and endurance, etc. The rapid increase may be 30%, 40%, 50% or more faster than when the nutritional composition is not given.

[0116] In some embodiments, the shortening of the delivery process of pregnant women includes but is not limited to: shortening the first stage of labor, the second stage of labor, the third stage of labor and / or the total stage of labor of pregnant women, preferably shortening the first stage of labor and the total stage of labor of pregnant women. Herein, the whole process from the beginning of regular uterine contractions to the delivery of the fetus and the placenta is called the "total stage of labor", and the total stage of labor is divided into three stages, namely the first stage of labor, the second stage of labor and the third stage of labor. The first stage of labor is the cervical dilation period, which refers to the period from the beginning of regular uterine contractions to the full opening of the cervical opening (10cm). The second stage of labor is the fetal delivery period, which refers to the period from the full opening of the cervical opening to the delivery of the fetus. The third stage of labor is the placental delivery period, which refers to the period from the delivery of the fetus to the delivery of the placenta. The shortening can be a reduction of more than 30%, more than 40%, more than 50% or more compared to when the nutritional composition is not given.

[0117] In some embodiments, the reduction of bleeding during childbirth in pregnant women includes but is not limited to: making the bleeding during childbirth in pregnant women less than 250 mL, preferably less than 245 mL, 244 mL, 243 mL, 242 mL, 241 mL or lower. The reduction can be 30% or more, 40% or more, 50% or more lower than when the nutritional composition is not given.

[0118] The nutritional composition of the present invention can also alleviate gastrointestinal reactions in pregnant women, such as shortening the storage time of the nutritional composition in the stomach, reducing the risk of nausea and vomiting, etc. Therefore, the present invention also provides the use of the nutritional composition in the preparation of a composition or a kit that can alleviate gastrointestinal reactions in pregnant women (including reducing the storage time of food in the stomach of pregnant women during labor, reducing the risk of nausea and vomiting).

[0119] In some embodiments, compared to traditional foods consumed during delivery (including delivery room meals provided by the delivery hospital, such as vegetable and lean meat porridge, noodles, vegetable dumplings, etc.) or existing similar nutritional formula preparations for pregnant women, the nutritional composition described in any embodiment of the present invention is retained in the stomach for less than 3 to 4 hours, preferably less than 1 to 1.5 hours.

[0120] Preparation method

[0121] The preparation method of the nutritional composition of the present invention is determined according to the dosage form to be prepared and the administration route. As a preferred embodiment of the present invention, the method for preparing the nutritional composition of the present invention comprises: mixing maltodextrin, protein powder, glucose, triglyceride powder, blueberry fruit powder, fructose, minerals, vitamins and salt to obtain a total mixture, preferably the total mixture is a powdered mixture.

[0122] In some embodiments, a method of preparing a nutritional composition of the present invention comprises:

[0123] 1) mixing calcium lactate (e.g., L-calcium lactate), magnesium sulfate, ferrous gluconate, and zinc gluconate to form a mineral mixture,

[0124] 2) mixing vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, pantothenic acid and folic acid to form a vitamin mixture, and

[0125] 3) The mineral mixture obtained in 1) and the vitamin mixture obtained in 2) are mixed with maltodextrin, protein powder, glucose, triglyceride powder, blueberry fruit powder, fructose and salt to obtain a total mixture.

[0126] It should be understood that the prepared nutritional composition can be stored in a container (such as a kit) by packaging, filling, etc. Therefore, the present invention also provides a kit, which contains the nutritional composition described in any embodiment of the present invention.

[0127] The kit can be any kit suitable for clinical application, and can be in various forms, such as but not limited to a packaging bottle. A water injection line can be further provided on the packaging bottle according to actual needs, so as to prepare the nutritional composition into a specific concentration for consumption.

[0128] Advantages of the present invention include:

[0129] The present invention combines the needs of clinical pregnant women during childbirth to quickly provide energy, supplement electrolytes, low fat, easy digestion and absorption, reduce the storage time in the stomach, fresh taste, and improve the production force, and provides a nutritional composition and preparation method thereof for fast and balanced nutritional supplementation for pregnant women during childbirth. The nutritional composition has a rapid energy supply effect that is better than Red Bull, and can increase the total movement distance and ATP content of zebrafish. Pregnant women drink the nutritional composition before or during childbirth, which can quickly provide the energy needed by pregnant women during childbirth, significantly improve the speed of cervical dilation, effectively avoid the phenomenon of insufficient production force, and significantly shorten the labor process of pregnant women, especially the first stage of labor, promote normal delivery, and reduce the amount of bleeding during childbirth.

[0130] The present invention will be further described below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods in the following examples without specifying specific conditions are usually carried out under conventional conditions or under conditions recommended by the manufacturer.

[0131] Example 1: Formula of nutritional composition for rapid and balanced nutritional supplementation for pregnant women during childbirth

[0132] The present embodiment provides a nutritional composition for rapid and balanced nutritional supplementation for pregnant women during childbirth, which is designed according to the energy and nutrient requirements of the childbearing population during the perinatal period and the metabolic state of the body, and is composed of the following ingredients: 30.15 parts by weight of maltodextrin, 20.5 parts by weight of isolated whey protein powder, 20 parts by weight of anhydrous glucose, 10 parts by weight of triglyceride powder (wherein the triglyceride powder contains 70% by weight of medium-chain triglycerides), 6 parts by weight of blueberry fruit powder, 5 parts by weight of crystalline fructose, 5.8 parts by weight of complex minerals (containing 3.65 parts by weight of L-lactate calcium, 1.365 parts by weight of magnesium sulfate, 0.185 parts by weight of glucosamine, 1.25 parts by weight of sodium dextrose, 1.365 parts by weight of sodium dextrose ... 0.053 weight part of zinc gluconate, and the rest are auxiliary materials), 1 weight part of compound vitamins (containing 0.007 weight part of vitamin A, 0.0038 weight part of vitamin D, 0.024 weight part of vitamin E, 0.0029 weight part of vitamin B1, 0.029 weight part of vitamin B2, 0.075 weight part of vitamin B6, 0.0043 weight part of vitamin B12, 0.168 weight part of vitamin C, 0.017 weight part of niacin, 0.0081 weight part of pantothenic acid and 0.005 weight part of folic acid, and the rest are auxiliary materials), 0.85 weight part of potassium citrate and 0.7 weight part of edible salt. The nutritional composition is produced in a GMP workshop. The nutritional composition is prepared into 50 g of a powdered product (i.e., composed of the following components: 15.075 g of maltodextrin, 10.25 g of isolated whey protein powder, 10 g of anhydrous glucose, 3 g of blueberry fruit powder, 2.5 g of crystalline fructose, 2.9 g of complex minerals, 0.5 g of vitamins, 0.425 g of potassium citrate and 0.35 g of edible salt) according to a total weight of 100 parts. The powdered product is obtained and filled into packaging bottles according to a production process of raw material acceptance → raw material unpacking and sterilization → weighing and feeding → premixing → total mixing → packaging.

[0133] The nutritional compositions of Example 2 and Example 1 have the effect of rapid energy supply

[0134] In this example, Red Bull was used as a positive control to examine the effects of the nutritional composition in Example 1 on the total movement distance and ATP content of zebrafish, so as to observe whether it has the effect of rapid energy supply.

[0135] 1. Experimental Materials

[0136] 1.1. Samples and controls

[0137] Sample: The nutritional composition described in Example 1, with a specification of 50.0 g / bottle × 1 bottle, in powder form, diluted with standard dilution water as a solvent to obtain samples with final concentrations of 125 μg / mL, 250 μg / mL, 500 μg / mL, 1000 μg / mL and 2000 μg / mL, respectively.

[0138] Positive control: Red Bull, yellow liquid, batch number 20240725, Red Bull Vitamin Drink Co., Ltd., directly absorb the original liquid when using.

[0139] 1.2. Experimental animals

[0140] Zebrafish were kept in aquaculture water at 28°C (water quality: 200 mg instant sea salt was added to 1 L of reverse osmosis water, conductivity was 450-550 μS / cm; pH was 6.5-8.5; hardness was 50-100 mg / L CaCO 3 ), the experimental animal use license number is: SYXK(Zhejiang)2022-0004, the feeding and management are in compliance with the requirements of the international AAALAC certification (certification number: 001458), and the IACUC ethics review number is: IACUC-2025-11390-01.

[0141] 1.3. Instruments, consumables and reagents

[0142] Dissecting microscope (SZX7, OLYMPUS, Japan); CCD camera (VertA1, Shanghai Tusen Vision Technology Co., Ltd., China); precision electronic balance (CP214, OHAUS, USA); motorized focus continuous zoom fluorescence microscope (AZ100, Nikon, Japan); 6-well plate (Zhejiang Bellambo Biotechnology Co., Ltd., China); 96-well plate (Nest Biotech, China); zebrafish behavior analysis system (Zebra Lab 3.22.3.31, Viewpoint, China); white 96-well ELISA plate (Nest Biotech, China).

[0143] Anhydrous sodium sulfite (Batch No. I1428128, Shanghai Aladdin Biochemical Technology Co., Ltd., China); ATP content determination kit (Batch No. 0000511614, Promega, USA).

[0144] 2. Detection Method

[0145] 2.1. Determination of maximum detectable concentration (MTC)

[0146] Wild-type AB strain zebrafish at 4 days post-fertilization (dpf) were randomly selected in 6-well plates, and 30 zebrafish were treated in each well. The samples were dissolved in standard dilution water and administered (the sample concentrations were 125μg / mL, 250μg / mL, 500μg / mL, 1000μg / mL and 2000μg / mL, respectively), and the volume of each well was 3mL. At the same time, a normal control group and a model control group were set up, and 3mL of standard dilution water without any substance was administered to the normal control group and the model control group. After 18h of treatment at 28℃, 8mg / mL of anhydrous sodium sulfite was administered to all experimental groups except the normal control group to establish a zebrafish fatigue model. After 1h of treatment at 28℃, the maximum detection concentration of the sample on the model zebrafish was determined.

[0147] 2.2. Rapid energy supply efficacy evaluation (total movement distance)

[0148] 4dpf wild-type AB strain zebrafish were randomly selected in 6-well plates, and 30 zebrafish were treated in each well. The samples were dissolved in standard dilution water and administered (the sample concentrations were 125μg / mL, 250μg / mL and 500μg / mL, respectively). The positive control group was given 20.8μL / mL of Red Bull, and the volume of each well was 3mL. At the same time, a normal control group and a model control group were set up, and 3mL of standard dilution water without any substance was given to the normal control group and the model control group. After 18h of treatment at 28℃, except for the normal control group, the rest of the experimental groups were given 8mg / mL of anhydrous sodium sulfite in water to establish a zebrafish fatigue model. After 28℃ treatment for 1h, 10 zebrafish were randomly selected from each experimental group and placed in a 96-well plate. The total movement distance of the zebrafish in 1h was measured using a behavior analyzer. The statistical analysis results of this indicator were used to evaluate the efficacy of the sample's rapid energy supply. SPSS26.0 software was used for statistical analysis, and the statistical analysis results were expressed as mean±SE. p<0.05 indicated that the difference was statistically significant.

[0149] 2.3. Rapid energy supply efficacy evaluation (ATP content)

[0150] 4dpf wild-type AB strain zebrafish were randomly selected in a 6-well plate, and 30 zebrafish were treated in each well. The samples were dissolved in standard dilution water and administered (the sample concentrations were 125μg / mL, 250μg / mL and 500μg / mL, respectively). The positive control group was administered with 20.8μL / mL of Red Bull, and the volume of each well was 3mL. At the same time, a normal control group and a model control group were set up, and 3mL of standard dilution water without any substance was administered to the normal control group and the model control group. After 18h of treatment at 28℃, except for the normal control group, the rest of the experimental groups were administered with 8mg / mL of anhydrous sodium sulfite in water to establish a zebrafish fatigue model. After 1h of treatment at 28℃, the ATP content assay kit (batch number 0000511614, Promega, USA) was used to operate according to the method, and the SPARKCON TROLDashboard software was used to collect data. The ATP content in zebrafish was analyzed, and the statistical analysis results of this indicator were used to evaluate the rapid energy supply efficacy of the sample. SPSS26.0 software was used for statistical analysis. The results were expressed as mean±SE, and p<0.05 indicated that the difference was statistically significant.

[0151] 3. Test results

[0152] 3.1. Maximum detectable concentration (MTC)

[0153] The results are shown in Table 1. The results show that the nutritional composition samples of Example 1 did not cause death of zebrafish at a concentration of 125-500 μg / mL, and no obvious abnormalities were observed. At concentrations of 1000 and 2000 μg / mL, the state was worse than that of the model control group, specifically manifested as slow swimming. Therefore, under the experimental conditions, the maximum detection concentration (MTC) of the nutritional composition of Example 1 for anti-fatigue efficacy in zebrafish is 500 μg / mL.

[0154] Table 1. Results of the rapid energy supply efficiency concentration test of samples (n=30)

[0155]

[0156]

[0157] 3.2. Rapid energy supply evaluation (total movement distance)

[0158] The results are shown in Table 2 and Figure 1 As shown, the results show that under the experimental conditions, the nutritional composition of Example 1 has a rapid energy supply effect, which is specifically manifested in increasing the total movement distance of zebrafish.

[0159] Table 2. Experimental results of rapid energy supply efficacy evaluation (total movement distance) of samples (n=10)

[0160]

[0161] Note: **p<0.01 compared with the model control group.

[0162] 3.3. Rapid energy supply efficacy evaluation (ATP content)

[0163] The results show that under the experimental conditions, the nutritional composition of Example 1 has a rapid energy supply effect, which is specifically manifested in increasing the ATP content of zebrafish. See Table 3 and Figure 2 .

[0164] Table 3. Experimental results of rapid energy supply efficacy evaluation (ATP content) of samples (n=10)

[0165]

[0166]

[0167] Note: Compared with the model control group, **p<0.01, ***p<0.001.

[0168] 3.4 Statistical analysis

[0169] The results of total exercise distance and ATP content were statistically analyzed: if the data met the normality and variance homogeneity, one-way analysis of variance was used for inter-group comparison analysis; if not, Kruskal-Wallis test was used. Tukey's HSD test was further used for pairwise comparison among the three groups, and P < 0.05 was considered statistically significant.

[0170] The results are shown in Table 4.

[0171] Table 4. Statistical analysis results of the rapid energy supply efficacy of samples

[0172]

[0173] Note: P value is the overall comparison, and P1 value is the comparison between the model control group and the nutritional composition 500 μg / mL group.

[0174] The results showed that the comparison among the three groups found that there were significant differences in both the total exercise distance and ATP content among the three groups (P < 0.001). From the results of the pairwise comparison of the total exercise distance, there was a significant difference between the 500μg / mL nutritional composition group and the model control group (P < 0.001); there was a significant difference between the model control group and the Red Bull 20.8μL / mL group (P = 0.002). The 500μg / mL nutritional composition group increased the total exercise distance by 54.63% compared with the model control group, the Red Bull 20.8μL / mL increased the total exercise distance by 52.41% compared with the model control group, and the 500μg / mL nutritional composition group increased by 2.22% compared with the Red Bull 20.8μL / mL.

[0175] From the results of pairwise comparison of ATP content, there was a significant difference between the 500μg / mL nutritional composition group and the model control group (P<0.001); there was a significant difference between the model control group and the Red Bull 20.8μL / mL group (P=0.004). Compared with the ATP content in the model control group, the 500μg / mL nutritional composition group increased the ATP content by 1.6 times more than the Red Bull 20.8μL / mL group.

[0176] Therefore, from the pairwise comparison results of the total exercise distance and ATP content, it can be seen that there are significant differences in the total exercise distance and ATP content between the 500 μg / mL nutritional composition group and the model control group, and between the model control group and Red Bull 20.8 μL / mL. In terms of the total exercise distance and ATP content between the 500 μg / mL nutritional composition group and Red Bull 20.8 μL / mL, the test results of the 500 μg / mL nutritional composition group were higher than those of the Red Bull group 20.8 μL / mL.

[0177] Effects of the nutritional composition of Example 3 and Example 1 on pregnant women

[0178] 1. Research Methods

[0179] Pregnant women in the control group were supplemented with delivery room meals (vegetable and lean meat porridge, noodles, vegetable dumplings, etc.) provided by the delivery hospital during delivery, as well as chocolate and functional drinks prepared by themselves.

[0180] The conventional pregnant women's nutritional formula group (hereinafter referred to as the conventional formula group) adds two pregnant women's nutritional formula preparations as snacks on the basis of the control group, and the energy of one cup of preparation is 250Kcal (300mL). The pregnant women's nutritional formula preparation is prepared by the hospital's enteral preparation room and consists of the following ingredients: 40 parts by weight (40g) of Quan Ansu (Abbott), 3 parts by weight (3g) of whey protein powder (Licun), 5 parts by weight (5g) of maltodextrin (Licun), 2 parts by weight (2g) of medium-chain fatty acids (Licun), specifications 50.0g / cup × 1 cup, the physical state is liquid, and it is drunk in small amounts and multiple times.

[0181] The nutritional composition group was given 2 additional nutritional composition preparations as a snack every day on the basis of the control group. The nutritional composition of the present invention was prepared according to the formula described in Example 1, with a specification of 50.0 g / bottle×1 bottle, in a powdered state, and was prepared with an appropriate amount of warm water and drunk in small amounts multiple times.

[0182] 2. Research Results

[0183] 2.1. General Information

[0184] The age, pregnancy number and gestational age of pregnant women in the conventional formula group, nutritional combination group and control group were compared. There was no statistically significant difference in the baseline data among the three groups (P>0.05), as shown in Table 5.

[0185] Table 5. Comparison of general information of three groups of pregnant women

[0186]

[0187]

[0188] 2.2. Labor time

[0189] There were statistical differences in the first stage of labor and the total stage of labor among the three groups (P < 0.05). There were no significant differences in the second and third stages of labor among the three groups (P > 0.05), as shown in Table 6. Further inter-group comparisons showed that the first stage of labor and the total stage of labor in the nutritional combination group were shorter than those in the conventional formula group and the control group, and the difference was statistically significant (P < 0.05).

[0190] Table 6. Comparison of labor time in three groups of pregnant women

[0191]

[0192] Note: * indicates that the differences were statistically significant after further pairwise comparison using the SNK-q test.

[0193] 2.3. Mode of delivery

[0194] Comparing the delivery methods of the three groups, the proportion of normal delivery in the nutritional combination group was 1.6% and 3.1% higher than that in the conventional formula group and the control group, respectively, and the proportion of low forceps delivery was 1.6% and 3.1% lower, respectively (see Table 7).

[0195] Table 7. Comparison of delivery methods among three groups of pregnant women (n / %)

[0196]

[0197] 2.4. Maternal and infant outcomes

[0198] The amount of bleeding during labor in the three groups of pregnant women was compared, and there was a statistical difference (P < 0.05). Further inter-group comparison showed that there was a statistical difference between the nutritional composition group and the control group (P = 0.025, using SNK-q test for pairwise comparison, the difference was statistically significant), and the amount of bleeding during labor in the nutritional composition group was 14.06 mL less than that in the conventional formula group. The 1-minute and 5-minute Apgar scores and neonatal weights of the three groups of newborns were normal. Due to the effective shortening of the labor process, the 1-minute Apgar score of the newborn in the nutritional composition group was relatively slightly higher, as shown in Table 8.

[0199] Table 8. Comparison of maternal and infant outcomes among the three groups of pregnant women

[0200]

[0201] Note: * indicates that the differences were statistically significant after further pairwise comparison using the SNK-q test.

[0202] 2.5 Gastrointestinal reactions

[0203] The gastrointestinal reactions, such as nausea and vomiting, were compared among the three groups. The results showed that the nausea incidence in the nutritional combination group was 3.1% and 7.8% lower than that in the conventional formula group and the control group, respectively; and the vomiting incidence was 3.1% and 4.7% lower than that in the conventional formula group and the control group, respectively (see Table 9).

[0204] Table 9. Incidence of gastrointestinal reactions during labor in the three groups of pregnant women (n / %)

[0205]

[0206] As shown in Tables 5-9, the cervical dilation rate of pregnant women in the nutritional combination group was significantly improved, and the delivery process was effectively shortened, especially the first stage of labor and the total stage of labor were shorter. The amount of bleeding during delivery in the nutritional combination group was lower than that in the conventional formula group and the control group. At the same time, the Apgar scores of newborns delivered by pregnant women in the nutritional combination group at 1 minute and 5 minutes were higher than those in the conventional formula group, which can reduce the risk of neonatal asphyxia and reduce the incidence of gastrointestinal reactions (such as nausea and vomiting) during delivery.

[0207] Based on the above experimental results, the nutritional composition of the present invention can effectively meet the energy needs of pregnant women during delivery, improve the labor force of pregnant women, accelerate the rate of cervical dilation, shorten the delivery process, increase the rate of normal delivery, reduce the rate of low-position forceps delivery, and alleviate gastrointestinal reactions.

[0208] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A nutritional composition, comprising: maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salt.

2. The nutritional composition according to claim 1, characterized in that The nutritional composition comprises: 26 to 35 parts by weight of maltodextrin, preferably 28 to 32 parts by weight of maltodextrin, 17 to 23 parts by weight of protein powder, preferably 19 to 22 parts by weight of protein powder, 15 to 23 parts by weight of glucose, preferably 18 to 22 parts by weight of glucose, 5 to 15 parts by weight of triglyceride powder, preferably 8 to 12 parts by weight of triglyceride powder, 2 to 8 parts by weight of fruit powder, preferably 5 to 8 parts by weight of fruit powder, 2 to 8 parts by weight of fructose, preferably 3 to 7 parts by weight of fructose, 2 to 8 parts by weight of minerals, preferably 4 to 7 parts by weight of minerals, 0.1 to 2 parts by weight of vitamins, preferably 0.5 to 1.5 parts by weight of vitamins, 0.5 to 2 parts by weight of the salt, preferably 0.5 to 1.6 parts by weight of the salt.

3. The nutritional composition according to claim 1 or 2, characterized in that The minerals include: calcium lactate, magnesium sulfate, ferrous gluconate, zinc gluconate, or a combination thereof; Preferably, the minerals include: 3-5 parts by weight of calcium lactate, 1-2 parts by weight of magnesium sulfate, 0.1-0.3 parts by weight of ferrous gluconate and 0.02-0.08 parts by weight of zinc gluconate.

4. The nutritional composition according to any one of claims 1 to 3, characterized in that The vitamins include: vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, pantothenic acid, folic acid, or a combination thereof; Preferably, the vitamins include: 0.005-0.01 parts by weight of vitamin A, 0.001-0.005 parts by weight of vitamin D, 0.01-0.05 parts by weight of vitamin E, 0.001-0.005 parts by weight of vitamin B1, 0.01-0.05 parts by weight of vitamin B2, 0.05-0.1 parts by weight of vitamin B6, 0.001-0.006 parts by weight of vitamin B12, 0.1-0.3 parts by weight of vitamin C, 0.01-0.03 parts by weight of niacin, 0.005-0.01 parts by weight of pantothenic acid and 0.001-0.01 parts by weight of folic acid.

5. The nutritional composition according to any one of claims 1 to 4, characterized in that The nutritional composition may further include one or more of the following features: (1) The protein powder comprises: whey protein powder, soy protein isolate powder or cod collagen powder, or a combination thereof; preferably, the protein powder is whey protein powder; (2) The glucose is anhydrous glucose; (3) The fructose is crystalline fructose; (4) The triglyceride powder contains medium-chain triglycerides, preferably the triglyceride powder contains at least 30% by weight of medium-chain triglycerides, more preferably at least 50% by weight of medium-chain triglycerides, and more preferably at least 70% by weight of medium-chain triglycerides; (5) The salt is a potassium salt, an edible salt or a combination thereof, preferably potassium citrate and edible salt, more preferably 0.5 to 1 parts by weight of potassium citrate and 0.5 to 1 parts by weight of edible salt; (6) The fruit powder is blueberry fruit powder.

6. The nutritional composition according to any one of claims 1 to 5, characterized in that The nutritional composition consists of the following ingredients: 26 to 35 parts by weight of maltodextrin, preferably 28 to 32 parts by weight of maltodextrin, 17 to 23 parts by weight of protein powder, preferably 19 to 22 parts by weight of protein powder, 15 to 23 parts by weight of glucose, preferably 18 to 22 parts by weight of glucose, 5 to 15 parts by weight of triglyceride powder, preferably 8 to 12 parts by weight of triglyceride powder, 2 to 8 parts by weight of blueberry powder, preferably 5 to 8 parts by weight of blueberry powder, 2 to 8 parts by weight of crystalline fructose, preferably 3 to 7 parts by weight of crystalline fructose, 2 to 8 parts by weight of minerals, preferably 4 to 7 parts by weight of minerals, 0.1 to 2 parts by weight of vitamins, preferably 0.5 to 1.5 parts by weight of vitamins, 0.5 to 1 parts by weight of potassium citrate, and 0.5 to 1 parts by weight of edible salt; Preferably, the minerals include: 3 to 5 parts by weight of calcium lactate, 1 to 2 parts by weight of magnesium sulfate, 0.1 to 0.3 parts by weight of ferrous gluconate and 0.02 to 0.08 parts by weight of zinc gluconate, and / or the vitamins include: 0.005 to 0.01 parts by weight of vitamin A, 0.001 to 0.005 parts by weight of vitamin D, 0.01 to 0.05 parts by weight of vitamin E, 0.001 to 0.005 parts by weight of vitamin B1, 0.01 to 0.05 parts by weight of vitamin B2, 0.05 to 0.1 parts by weight of vitamin B6, 0.001 to 0.006 parts by weight of vitamin B12, 0.1 to 0.3 parts by weight of vitamin C, 0.01 to 0.03 parts by weight of niacin, 0.005 to 0.01 parts by weight of pantothenic acid and 0.001 to 0.01 parts by weight of folic acid.

7. A method for preparing a nutritional composition, the method comprising: mixing maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose, minerals, vitamins and salt to obtain a total mixture; Preferably, the preparation method comprises: 1) Mix calcium lactate, magnesium sulfate, ferrous gluconate and zinc gluconate to form a mineral mixture, 2) mixing vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, pantothenic acid and folic acid to form a vitamin mixture, and 3) mixing the mineral mixture obtained in 1) and the vitamin mixture obtained in 2) with maltodextrin, protein powder, glucose, triglyceride powder, fruit powder, fructose and salt to obtain a total mixture; More preferably, the nutritional composition is as described in any one of claims 1-6.

8. Use of the nutritional composition according to any one of claims 1 to 6, or the nutritional composition prepared by the preparation method according to claim 7, in an aspect selected from the following: (A) Use in the preparation of a composition or a kit for providing nutrition to pregnant women; (B) Use in the preparation of a composition or kit that can quickly supply energy to pregnant women, shorten the delivery process of pregnant women, reduce the amount of bleeding during delivery, and / or alleviate gastrointestinal reactions in pregnant women; Preferably, the pregnant women include pregnant women who are about to give birth, pregnant women in labor and women after giving birth, more preferably pregnant women in labor; Preferably, the pregnant women include pregnant women who are about to give birth and pregnant women in labor, more preferably pregnant women in labor; Preferably, the rapid energy supply comprises: Rapidly increase ATP content, exercise capacity and endurance; Preferably, shortening the delivery process of the pregnant woman includes: shortening the first stage of labor, the second stage of labor, the third stage of labor and / or the total stage of labor of the pregnant woman, more preferably shortening the first stage of labor and the total stage of labor of the pregnant woman; Preferably, reducing the amount of bleeding during childbirth in pregnant women includes: reducing the amount of bleeding during childbirth in pregnant women to less than 250 mL, more preferably less than 245 mL; Preferably, the gastrointestinal reactions include: nausea and vomiting.

9. A composition or kit, characterized in that: The composition or kit contains an effective amount of the nutritional composition according to any one of claims 1 to 6; Preferably, the effective amount of the nutritional composition is 100-2000 μg / mL, more preferably 125-500 μg / mL or 250-500 μg / mL; More preferably, the composition or kit further comprises a pharmaceutically, nutraceutical, nutritionally or food-acceptable carrier; More preferably, the kit is a packaging bottle.

10. A non-therapeutic method for providing nutrition to pregnant women, and / or quickly supplying energy to pregnant women, shortening the delivery process of pregnant women, reducing the amount of bleeding during delivery, and / or alleviating gastrointestinal reactions of pregnant women, the method comprising: Providing an effective amount of the nutritional composition according to any one of claims 1 to 6 or the nutritional composition prepared by the preparation method according to claim 7 to the pregnant woman, or providing the composition or kit according to claim 9 to the expectant mother, the pregnant woman giving birth, or the parturient; Preferably, the effective amount of the nutritional composition is 100-2000 μg / mL, more preferably 125-500 μg / mL or 250-500 μg / mL; Preferably, the pregnant women include pregnant women who are about to give birth, pregnant women in labor and women after giving birth, more preferably pregnant women in labor; Preferably, the pregnant women include pregnant women who are about to give birth and pregnant women in labor, more preferably pregnant women in labor; Preferably, the rapid energy supply includes: rapidly increasing ATP content, rapidly increasing athletic ability and endurance; Preferably, shortening the delivery process of the pregnant woman includes: shortening the first stage of labor, the second stage of labor, the third stage of labor and / or the total stage of labor of the pregnant woman, more preferably shortening the first stage of labor and the total stage of labor of the pregnant woman; Preferably, reducing the amount of bleeding during childbirth in pregnant women includes: reducing the amount of bleeding during childbirth in pregnant women to less than 250 mL, more preferably less than 245 mL; Preferably, the gastrointestinal reactions include: nausea and vomiting.

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