Hydrocolloid dressing and preparation method thereof

Abstract

The invention provides a hydrocolloid dressing and a preparation method thereof, and belongs to the technical field of medical dressings. A hydrocolloid dressing comprises a base material layer, a hydrocolloid layer and a release layer, and the hydrocolloid layer is located between the base material layer and the release layer. The hydrocolloid layer is prepared from the following raw materials in parts by weight: 10-70 parts of a hydrophilic polymer, 8-50 parts of thermoplastic rubber, 5-20 parts of a plasticizer, 10-60 parts of tackifying resin, 1-5 parts of an absorption enhancer, 0.1-3 parts of an antioxidant and 0.1-3 parts of an anti-aging agent. The hydrocolloid dressing is used for improving the viscosity, comfort and liquid absorption performance of the product, so that the hydrocolloid dressing has better use performance on skin injuries caused by wounds, scalds, small operations and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of medical dressings, and in particular relates to a hydrocolloid dressing and a preparation method thereof. Background Art

[0002] Hydrocolloid dressings are a new type of wound dressing developed under the guidance of the moist healing principle. They can help control bleeding, prevent infection, absorb secretions, and accelerate wound healing after loading various functional substances. The main purpose of this type of dressing is to create a moist, sterile environment on the wound surface, which can enhance the activity of macrophages and fibroblasts, thereby increasing epithelial regeneration and relieving pain and itching caused by dryness during the healing process.

[0003] The ideal hydrocolloid dressing should have the following characteristics: quickly absorb the exudate around the wound; provide a moist environment for the wound to facilitate cell growth while also having a certain water vapor permeability and effective oxygen circulation, so that the wound will not produce edema and eczema due to excessive moisture; have a certain adhesion to the wound and be easy to remove without causing secondary damage to the wound; have a suitable pH range to maintain the normal growth and metabolic activities of cells at the wound; have controllable residues of solvents or adjuvants and other additives, and have no toxic effects on the wound and surrounding cells; have good mechanical properties, and the dressing should preferably be similar to the mechanical strength of the tissue at the wound to put the human body in a comfortable environment; have appropriate elasticity, thickness and tension, so that the dressing can expand and contract with the movement of certain parts of the human body, so as not to be too tight and tear the wound, and at the same time, the dressing is easy to fix on the wound and is simple to operate; have a certain degree of biological comfort, be non-toxic, non-sensitizing, and non-irritating; have a certain degree of biodegradability; can effectively prevent the invasion of bacteria and other microorganisms and prevent wound infection; the dressing should preferably have a certain degree of transparency or promptability to facilitate doctors or patients to observe the condition of the wound.

[0004] There are many hydrocolloid dressing products at present, which generally have the functions of absorbing exudate, providing a moist environment and preventing adhesion. However, each product has some shortcomings to a greater or lesser extent. For example, there are individual differences in the persistence of adhesion. If the edge is not tightly attached to the skin (such as parts of joints with frequent movements), moisture may seep in through the gap. There is also a high risk of allergy, and sensitive skin cannot be used safely, for example, when using resin rosin. These shortcomings need to be further studied and improved by industry personnel. Summary of the invention

[0005] In view of this, the technical problem to be solved by the present invention is to provide a hydrocolloid dressing to improve the viscosity, comfort and liquid absorption performance of the product, so that the hydrocolloid dressing has better performance for skin damage caused by trauma, burns, minor surgery, etc.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer, and the hydrocolloid layer is made of the following raw materials in parts by weight: 10-70 parts of a hydrophilic polymer, 8-50 parts of a thermoplastic rubber, 5-20 parts of a plasticizer, 10-60 parts of a tackifying resin, 1-5 parts of an absorption promoter, 0.1-3 parts of an antioxidant, and 0.1-3 parts of an anti-aging agent.

[0007] Optionally, the hydrophilic polymer is selected from one or more of agar, xanthan gum, fish glue, polyvinyl alcohol, carboxymethyl chitosan and sodium hyaluronate. Preferably, the hydrophilic polymer is selected from a combination of agar and carboxymethyl chitosan, and the mass ratio of agar to carboxymethyl chitosan is 1: (1~3).

[0008] Optionally, the thermoplastic rubber is selected from styrene-isoprene-styrene block copolymer or methyl methacrylate ethyl acrylate copolymer, wherein the methyl methacrylate ethyl acrylate copolymer is completely polymerized and the residual monomers meet the safety standards.

[0009] Optionally, the plasticizer is selected from one or more of diisooctyl phthalate, diisodecyl phthalate, diisobutyl phthalate, diethyl phthalate, dicyclohexyl phthalate, dioctyl adipate, dibutyl adipate, triethyl citrate, acetyl triethyl citrate and epoxidized soybean oil.

[0010] Optionally, the tackifying resin is selected from one or two of hydrogenated petroleum resin, tert-butylphenol formaldehyde composite tackifying resin and terpene resin.

[0011] Optionally, the absorption promoter is selected from fatty acid esters or ethoxylates; The fatty acid ester is selected from menthol fatty acid ester, pineol fatty acid ester or glycerol fatty acid ester; The ethoxylate is selected from glycerol ethoxylate, fatty acid methyl ester ethoxylate, coconut alkyl quaternary amine ethoxylate or acetylene glycol ethoxylate.

[0012] Optionally, the antioxidant is selected from one or two of N-isopropyl-N-phenyl-p-phenylenediamine, dilauryl thiodipropionate and distearyl thiodipropionate.

[0013] Optionally, the anti-aging agent is selected from one or more of pentaerythritol tetrakis[β-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, 2,4,6-tri-tert-butylphenol and 2,6-di-tert-butyl-4-methylphenol.

[0014] Optionally, the hydrocolloid layer is made of the following raw materials in parts by weight: 10-30 parts of agar, 20-40 parts of carboxymethyl chitosan, 8-50 parts of methyl methacrylate ethyl acrylate copolymer, 5-20 parts of plasticizer, 10-60 parts of tert-butyl phenolic composite tackifying resin, 1-5 parts of absorption promoter, 0.1-3 parts of antioxidant, and 0.1-3 parts of anti-aging agent.

[0015] Optionally, the method for preparing the hydrocolloid layer comprises the following steps: Step S1: providing thermoplastic rubber, plasticizer, absorption promoter, antioxidant and anti-aging agent, and mixing the above raw materials at 130-150° C. for 60-80 minutes; Step S2: providing a hydrophilic polymer and a tackifying resin, adding the hydrophilic polymer and the tackifying resin into the mixture of step S1, and continuing to mix at 130-150° C. for 60-80 minutes to obtain a product.

[0016] Optionally, the mixing rotation speed in step S1 and step S2 is 20-65 rpm.

[0017] A method for preparing a hydrocolloid dressing comprises: coating the prepared hydrocolloid layer on the substrate layer, cooling the layer, and then covering the other side of the hydrocolloid layer with the release layer to obtain the product.

[0018] Compared with the prior art, the present invention has the following beneficial effects: The present invention provides a hydrocolloid dressing based on the above technical solution, in order to improve the viscosity, comfort and liquid absorption performance of the product, so that the hydrocolloid dressing has better performance for skin damage caused by trauma, burns, minor surgery, etc., and overcomes the problems of existing hydrocolloid dressing products such as unstable viscosity, slow or small liquid absorption, and sensitive use.

[0019] The hydrocolloid dressing of the present invention is preferably formulated with hydrophilic polymers, thermoplastic rubbers, plasticizers, tackifying resins, absorption promoters, antioxidants and anti-aging agents in specific proportions to improve the viscosity, comfort and liquid absorption of the hydrocolloid dressing, and the overall performance is enhanced by the synergistic effect of each component.

[0020] In the present invention, the hydrophilic polymer is selected from one or more of agar, xanthan gum, fish glue, polyvinyl alcohol, carboxymethyl chitosan and sodium hyaluronate, preferably a combination of agar and carboxymethyl chitosan, which has high biocompatibility, reduces irritation to the skin, absorbs wound exudate through the hydrophilic group to form a gel, maintains a moist environment, promotes healing, and cooperates with the tackifying resin to enhance the fit of the dressing to the skin. The preferred addition amount is 10-70 parts by weight, more preferably 30-60 parts by weight; the thermoplastic rubber is selected from styrene-isoprene-styrene block copolymer or methyl methacrylate ethyl acrylate copolymer to provide a structural skeleton for the hydrocolloid dressing, ensure that it has good flexibility and ductility, fits the skin for a long time, and prevents the dressing from being overly softened or broken after absorbing liquid; the thermoplastic resin and the plasticizer are combined to adjust the softness of the dressing to make it more skin-friendly and comfortable; the plasticizer is selected from diisooctyl phthalate, diisodecyl phthalate, diisodecyl phthalate One or more of isobutyl ester, diethyl phthalate, dicyclohexyl phthalate, dioctyl adipate, dibutyl adipate, triethyl citrate, acetyl triethyl citrate and epoxy soybean oil make the dressing softer and enhance the initial adhesion. The thermoplastic resin and plasticizer selected by the present invention have little irritation to the skin and are safer. The tackifying resin is preferably one or two of hydrogenated petroleum resin, tert-butyl phenolic composite tackifying resin and terpene resin, which improves the adhesion between the dressing and the skin and ensures the fixation. It cooperates with the hydrophilic polymer, thermoplastic resin and plasticizer to form a stable viscous network, locks the liquid and prevents reverse osmosis, and prolongs the service life of the dressing. The absorption promoter assists the hydrophilic polymer to quickly absorb and lock the liquid, prevents leakage, enhances the structural stability after liquid absorption, and avoids disintegration. At the same time, the appropriate ingredients and their added amounts will not have an adverse effect on the viscosity of the dressing. The antioxidant is used in combination with the anti-aging agent to prevent the oxidation and degradation of the ingredients and maintain the stability of the dressing viscosity and liquid absorption performance. The present invention achieves a balance between viscosity, liquid absorption and comfort by adjusting the proportion of each component and selecting a specific type of material, so that the hydrocolloid dressing has better performance for skin damage caused by trauma, scalds, minor surgery, etc.

[0021] The hydrocolloid dressing of the present invention has been tested and has a 24-hour liquid absorption amount of ≥2.3g and a 48-hour liquid absorption amount of ≥3.3g; it has strong viscosity, good stickiness, and a peel strength of ≥7.1N / cm, which can meet the needs of close adhesion during joint activities; in terms of comfort, it can withstand a static water pressure of 500mm for more than 300s, which can meet daily use needs; the hydrocolloid dressing has a comfortable touch, and its extensibility and permanent deformation meet the standards; the materials used are safe and have good biocompatibility, thereby improving the use experience. DETAILED DESCRIPTION

[0022] In order to better understand the present invention, the content of the present invention is further clearly set forth in conjunction with the embodiments below, but the protection content of the present invention is not limited to the following embodiments. In the following description, a large number of specific details are provided in order to provide a more thorough understanding of the present invention. However, it is obvious to those skilled in the art that the present invention can be implemented without one or more of these details.

[0023] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without making any creative work shall fall within the scope of protection of the present invention.

[0024] In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limiting. Therefore, other examples of the exemplary embodiments may have different values.

[0025] The numerical ranges and parameters shown in the present invention are approximate values, but the numerical values ​​shown in the specific embodiments are recorded as accurately as possible. However, all numerical values ​​essentially contain specific errors that are inevitably generated by the standard deviation seen in each experimental measurement value. In addition, the term "about" means within the allowable standard error when considered by those skilled in the art.

[0026] Unless otherwise specified, all raw materials are from commercially available products and do not contain other unspecified components except inevitable impurities unless otherwise specified.

[0027] In the following embodiments, the substrate layer is made of polyurethane film; and the release layer is made of release paper.

[0028] Embodiment 1: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0029] The hydrocolloid layer is made of the following raw materials in parts by weight: 45 parts of hydrophilic polymer, 18 parts of thermoplastic rubber, 12 parts of plasticizer, 18 parts of tackifying resin, 4 parts of absorption promoter, 2 parts of antioxidant, and 1 part of anti-aging agent. Among them, the hydrophilic polymer is a composition of agar and carboxymethyl chitosan, and the mass ratio of agar and carboxymethyl chitosan is 1:1; the thermoplastic rubber is a copolymer of methyl methacrylate and ethyl acrylate; the plasticizer is diisooctyl phthalate; the tackifying resin is terpene resin; the absorption promoter is coconut alkyl quaternary amine ethoxylate; the antioxidant is N-isopropyl-N-phenyl-p-phenylenediamine; the anti-aging agent is pentaerythritol tetra[β-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate].

[0030] The method for preparing the hydrocolloid layer comprises the following steps: Step S1: providing thermoplastic rubber, plasticizer, absorption promoter, antioxidant and anti-aging agent, and mixing the above raw materials at 145° C. for 60 minutes at a mixing speed of 25 rpm; Step S2: providing a hydrophilic polymer and a tackifying resin, adding the hydrophilic polymer and the tackifying resin into the mixture of step S1, and continuing to mix at 150° C. for 70 minutes at a mixing speed of 40 rpm to obtain a product.

[0031] The preparation method of the hydrocolloid dressing includes: coating the prepared hydrocolloid layer on the substrate layer, cooling, and then covering the other side of the hydrocolloid layer with a release layer to obtain the product. The preparation method of the hydrocolloid dressing in the following embodiments is the same as this and will not be repeated.

[0032] Embodiment 2: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0033] The hydrocolloid layer is made of the following raw materials in parts by weight: 50 parts of hydrophilic polymer, 12 parts of thermoplastic rubber, 5 parts of plasticizer, 27 parts of thickening resin, 3 parts of absorption promoter, 1 part of antioxidant, and 2 parts of anti-aging agent. Among them, the hydrophilic polymer is a combination of agar and carboxymethyl chitosan, and the mass ratio of agar to carboxymethyl chitosan is 1:3. The thermoplastic rubber is a copolymer of methyl methacrylate and ethyl acrylate. The plasticizer is dioctyl adipate. The thickening resin is a tert-butylphenolic composite thickening resin. The absorption promoter is a glycerol fatty acid ester. The antioxidant is dilauryl thiodipropionate. The anti-aging agent is 2,4,6-tri-tert-butylphenol.

[0034] The method for preparing the hydrocolloid layer comprises the following steps: Step S1: providing thermoplastic rubber, plasticizer, absorption promoter, antioxidant and anti-aging agent, and mixing the above raw materials at 130° C. for 75 minutes at a mixing speed of 40 rpm; Step S2: providing a hydrophilic polymer and a tackifying resin, adding the hydrophilic polymer and the tackifying resin into the mixture of step S1, and continuing to mix at 140° C. for 60 minutes at a mixing speed of 50 rpm to obtain a product.

[0035] Embodiment 3: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0036] The hydrocolloid layer is made of the following raw materials in parts by weight: 30 parts of hydrophilic polymer, 30 parts of thermoplastic rubber, 5 parts of plasticizer, 30 parts of tackifying resin, 4 parts of absorption promoter, 0.5 parts of antioxidant, and 0.5 parts of anti-aging agent. The hydrophilic polymer is a combination of agar and carboxymethyl chitosan, and the mass ratio of agar to carboxymethyl chitosan is 1:2. The thermoplastic rubber is styrene-isoprene-styrene block copolymer. The plasticizer is triethyl citrate. The tackifying resin is hydrogenated petroleum resin. The absorption promoter is glycerol ethoxylate. The antioxidant is distearyl thiodipropionate. The anti-aging agent is 2,6-di-tert-butyl-4-methylphenol.

[0037] The method for preparing the hydrocolloid layer comprises the following steps: Step S1: providing thermoplastic rubber, plasticizer, absorption promoter, antioxidant and anti-aging agent, and mixing the above raw materials at 143° C. for 80 minutes at a mixing speed of 50 rpm; Step S2: providing a hydrophilic polymer and a tackifying resin, adding the hydrophilic polymer and the tackifying resin into the mixture of step S1, and continuing to mix at 145° C. for 80 minutes at a mixing speed of 65 rpm to obtain a product.

[0038] Embodiment 4: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0039] The hydrocolloid layer is made of the following raw materials in parts by weight: 60 parts of hydrophilic polymer, 8 parts of thermoplastic rubber, 8 parts of plasticizer, 20 parts of tackifying resin, 1 part of absorption promoter, 2.9 parts of antioxidant, and 0.1 parts of anti-aging agent. Among them, the hydrophilic polymer is selected from xanthan gum. The thermoplastic rubber is selected from styrene-isoprene-styrene block copolymer. The plasticizer is selected from diisodecyl phthalate. The tackifying resin is selected from tert-butylphenolic composite tackifying resin. The absorption promoter is selected from menthol fatty acid ester. The antioxidant is selected from disoctadecyl thiodipropionate. The anti-aging agent is selected from pentaerythritol tetra[β-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate. The preparation method of the hydrocolloid layer is referenced to Example 1.

[0040] Embodiment 5: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0041] The hydrocolloid layer is made of the following raw materials in parts by weight: 55 parts of hydrophilic polymer, 15 parts of thermoplastic rubber, 10 parts of plasticizer, 14 parts of tackifying resin, 2 parts of absorptive agent, 1 part of antioxidant, and 3 parts of anti-aging agent. The hydrophilic polymer is polyvinyl alcohol. The thermoplastic rubber is methyl methacrylate ethyl acrylate copolymer. The plasticizer is dibutyl adipate. The tackifying resin is terpene resin. The absorbent is fatty acid methyl ester ethoxylate. The antioxidant is dilauryl thiodipropionate. The aging agent is 2,4,6-tri-tert-butylphenol. The preparation method of the hydrocolloid layer is referenced to Example 1.

[0042] Embodiment 6: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0043] The hydrocolloid layer is made of the following raw materials in parts by weight: 70 parts of hydrophilic polymer, 10 parts of thermoplastic rubber, 7 parts of plasticizer, 10 parts of tackifying resin, 1 part of absorption promoter, 1 part of antioxidant, and 1 part of anti-aging agent. The hydrophilic polymer is carboxymethyl chitosan. The thermoplastic rubber is methyl methacrylate ethyl acrylate copolymer. The plasticizer is triethyl acetyl citrate. The tackifying resin is tert-butyl phenolic composite tackifying resin. The absorption promoter is pine alcohol fatty acid ester. The antioxidant is dioctadecyl thiodipropionate. The anti-aging agent is 2,6-di-tert-butyl-4-methylphenol. The preparation method of the hydrocolloid layer is referenced to Example 1.

[0044] Embodiment 7: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0045] The hydrocolloid layer is made of the following raw materials in parts by weight: 65 parts of hydrophilic polymer, 13 parts of thermoplastic rubber, 6 parts of plasticizer, 12 parts of tackifying resin, 1 part of absorption promoter, 0.1 parts of antioxidant, and 2.9 parts of anti-aging agent. The hydrophilic polymer is selected from sodium hyaluronate. The thermoplastic rubber is selected from methyl methacrylate ethyl acrylate copolymer. The plasticizer is selected from epoxidized soybean oil. The tackifying resin is selected from hydrogenated petroleum resin and terpene resin, and the mass ratio of the two is 1:1. The absorption promoter is selected from acetylene glycol ethoxylate. The antioxidant is selected from N-isopropyl-N-phenyl-p-phenylenediamine and dilauryl thiodipropionate, and the mass ratio of the two is 1:1. The anti-aging agent is selected from 2,6-di-tert-butyl-4-methylphenol. The preparation method of the hydrocolloid layer is referenced to Example 1.

[0046] Embodiment 8: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0047] The hydrocolloid layer is made of the following raw materials in parts by weight: 20 parts of hydrophilic polymer, 20 parts of thermoplastic rubber, 18 parts of plasticizer, 35 parts of tackifying resin, 5 parts of absorption promoter, 1 part of antioxidant, and 1 part of anti-aging agent. The hydrophilic polymer is selected from xanthan gum and carboxymethyl chitosan, and the mass ratio of the two is 1:2. The thermoplastic rubber is selected from styrene-isoprene-styrene block copolymer. The plasticizer is selected from dicyclohexyl phthalate. The tackifying resin is selected from tert-butylphenolic composite tackifying resin. The absorption promoter is selected from coconut alkyl quaternary amine ethoxylate. The antioxidant is selected from disoctadecyl thiodipropionate. The anti-aging agent is selected from pentaerythritol tetrakis[β-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate] and 2,4,6-tri-tert-butylphenol, and the mass ratio of the two is 2:1. The preparation method of the hydrocolloid layer is referenced to Example 1.

[0048] Embodiment 9: A hydrocolloid dressing comprises a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer.

[0049] The hydrocolloid layer is made of the following raw materials in parts by weight: 10 parts of hydrophilic polymer, 40 parts of thermoplastic rubber, 20 parts of plasticizer, 21 parts of tackifying resin, 5 parts of absorption promoter, 2 parts of antioxidant, and 2 parts of anti-aging agent. The hydrophilic polymer is selected from a composition of polyvinyl alcohol and sodium hyaluronate, and the mass ratio of the two is 3:1. The thermoplastic rubber is selected from a copolymer of methyl methacrylate and ethyl acrylate. The plasticizer is selected from a composition of diisooctyl phthalate and triethyl acetyl citrate, and the mass ratio of the two is 1:0.5. The tackifying resin is selected from a tert-butylphenolic composite tackifying resin. The absorption promoter is selected from glycerol ethoxylate. The antioxidant is selected from N-isopropyl-N-phenyl-p-phenylenediamine. The anti-aging agent is selected from 2,6-di-tert-butyl-4-methylphenol. The preparation method of the hydrocolloid layer is referenced to Example 1.

[0050] Example 10: The difference from Example 1 is that the hydrocolloid layer is made of the following raw materials in parts by weight: 15 parts of hydrophilic polymer, 50 parts of thermoplastic rubber, 16 parts of plasticizer, 15 parts of tackifying resin, 1 part of absorption promoter, 2 parts of antioxidant, and 1 part of anti-aging agent.

[0051] Example 11: The difference from Example 1 is that the hydrocolloid layer is made of the following raw materials in parts by weight: 22 parts of hydrophilic polymer, 10 parts of thermoplastic rubber, 5 parts of plasticizer, 608 parts of tackifying resin, 1 part of absorption promoter, 2 parts of antioxidant, and 1 part of anti-aging agent.

[0052] Example 12: The difference from Example 1 is that the hydrocolloid layer is made of the following raw materials in parts by weight: 18 parts of hydrophilic polymer, 15 parts of thermoplastic rubber, 10 parts of plasticizer, 50 parts of tackifying resin, 4 parts of absorption promoter, 2 parts of antioxidant, and 1 part of anti-aging agent.

[0053] Comparative Example 1: A hydrocolloid dressing, which is different from Example 1 in that the hydrophilic polymer is sodium alginate.

[0054] Comparative Example 2: A hydrocolloid dressing, which is different from Example 1 in that the thermoplastic rubber is thermoplastic styrene-butadiene rubber.

[0055] Comparative Example 3: A hydrocolloid dressing, which is different from Example 1 in that the tackifying resin is gum rosin.

[0056] Comparative Example 4: A hydrocolloid dressing, which is different from Example 1 in that the absorption promoter is povidone K30.

[0057] Comparative Example 5: A hydrocolloid dressing, which is different from Example 1 in that the hydrophilic polymer is a composition of agar and sodium carboxymethyl cellulose, and the mass ratio of agar to sodium carboxymethyl cellulose is 1:1.

[0058] Next, the content of the evaluation test will be described. The evaluation test was carried out on the following evaluation items.

[0059] The inspection is based on YY / T1293.4-2016, and the evaluation items are shown in Table 1 below.

[0060] Table 1 Evaluation project standard requirements The hydrocolloid dressings (5×5 cm) prepared in Examples 1-6 and Comparative Examples 1-5 were tested. The test results are shown in Tables 2 and 3.

[0061] Table 2 Test results of Examples 1-6 Table 3 Test results of comparative examples 1-5 The results in Table 2 show that the hydrocolloid dressing of the present invention has a 24-hour liquid absorption amount of ≥2.3 g and a 48-hour liquid absorption amount of ≥3.3 g; it has strong viscosity, good adhesion retention, and a peel strength of ≥7.0 N / cm, which can meet the needs of tight adhesion during joint activities; in terms of comfort, it can withstand a hydrostatic pressure of 500 mm for more than 300 seconds, which can meet the needs of daily use; the hydrocolloid dressing has a comfortable touch, and its extensibility and permanent deformation meet the standards; the materials used are safe and have good biocompatibility.

[0062] The results in Table 3 show that in Comparative Example 1, the hydrophilic polymer in Example 1 was replaced with sodium alginate, and the liquid absorption and viscosity of the prepared hydrocolloid dressing were significantly reduced; in Comparative Example 2, the thermoplastic rubber in Example 1 was replaced with thermoplastic styrene-butadiene rubber, and the comfort of the prepared hydrocolloid dressing was significantly reduced; in Comparative Example 3, the viscosity of the prepared hydrocolloid dressing was reduced and the comfort was significantly reduced by replacing the tackifier in Example 1 with rosin; in Comparative Example 4, the absorption promoter in Example 1 was replaced with povidone K30, and the liquid absorption of the prepared hydrocolloid dressing was not as good as that of Example 1; in Comparative Example 5, the composition of the hydrophilic polymer was changed, and the liquid absorption of the prepared hydrocolloid dressing was reduced.

[0063] It can be seen that the hydrocolloid dressing is a complex system composed of multiple components, in which the hydrophilic polymer, thermoplastic rubber, tackifier and other components interact with each other and jointly affect the performance of the dressing. The reasonable combination and interaction of these components enable the hydrocolloid dressing to have good liquid absorption, viscosity and comfort at the same time, thereby providing a good healing environment for the wound surface. The synergistic effect between the various components in the hydrocolloid dressing of the present invention is a mutually unified whole, which plays an important and positive role in the performance of the product.

[0064] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Other modifications or equivalent substitutions made to the technical solution of the present invention by ordinary technicians in the field should be included in the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solution of the present invention.

Claims

1. A hydrocolloid dressing, comprising a substrate layer, a hydrocolloid layer and a release layer, wherein the hydrocolloid layer is located between the substrate layer and the release layer, and characterized in that: The hydrocolloid layer is made of the following raw materials in parts by weight: 10-70 parts of hydrophilic polymer, 8-50 parts of thermoplastic rubber, 5-20 parts of plasticizer, 10-60 parts of tackifying resin, 1-5 parts of absorption promoter, 0.1-3 parts of antioxidant and 0.1-3 parts of anti-aging agent.

2. A hydrocolloid dressing according to claim 1, characterized in that: The hydrophilic polymer is selected from one or more of agar, xanthan gum, fish glue, polyvinyl alcohol, carboxymethyl chitosan and sodium hyaluronate.

3. A hydrocolloid dressing according to claim 1, characterized in that: The thermoplastic rubber is selected from styrene-isoprene-styrene block copolymer or methyl methacrylate ethyl acrylate copolymer.

4. A hydrocolloid dressing as claimed in claim 1, characterized in that: The plasticizer is selected from one or more of diisooctyl phthalate, diisodecyl phthalate, diisobutyl phthalate, diethyl phthalate, dicyclohexyl phthalate, dioctyl adipate, dibutyl adipate, triethyl citrate, acetyl triethyl citrate and epoxidized soybean oil.

5. A hydrocolloid dressing as claimed in claim 1, characterized in that: The tackifying resin is selected from one or two of hydrogenated petroleum resin, tert-butylphenolic composite tackifying resin and terpene resin.

6. A hydrocolloid dressing according to claim 1, characterized in that: The absorption promoter is selected from fatty acid esters or ethoxylates; The fatty acid ester is selected from menthol fatty acid ester, pineol fatty acid ester or glycerol fatty acid ester; The ethoxylate is selected from glycerol ethoxylate, fatty acid methyl ester ethoxylate, coconut alkyl quaternary amine ethoxylate or acetylene glycol ethoxylate.

7. A hydrocolloid dressing according to claim 1, characterized in that: The antioxidant is selected from one or two of N-isopropyl-N-phenyl-p-phenylenediamine, dilauryl thiodipropionate and distearyl thiodipropionate.

8. A hydrocolloid dressing as claimed in claim 1, characterized in that: The anti-aging agent is selected from one or more of pentaerythritol tetrakis[β-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, 2,4,6-tri-tert-butylphenol and 2,6-di-tert-butyl-4-methylphenol.

9. A hydrocolloid dressing as claimed in claim 1, characterized in that: The method for preparing the hydrocolloid layer comprises the following steps: Step S1: providing thermoplastic rubber, plasticizer, absorption promoter, antioxidant and anti-aging agent, and mixing the above raw materials at 130-150° C. for 60-80 minutes; Step S2: providing a hydrophilic polymer and a tackifying resin, adding the hydrophilic polymer and the tackifying resin into the mixture of step S1, and continuing to mix at 130-150° C. for 60-80 minutes to obtain a product.

10. A method for preparing a hydrocolloid dressing according to any one of claims 1 to 9, characterized in that: include: The prepared hydrocolloid layer is coated on the substrate layer, cooled, and then the release layer is coated on the other side of the hydrocolloid layer to obtain a product.

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