Microfluid electromagnetic array chip and automatic microfluid electromagnetic array control system

Abstract

The invention discloses a microfluid electromagnetic array chip and an automatic microfluid electromagnetic array control system, and belongs to the technical field of microfluidics. The chip at least comprises a micro-channel layer and an electromagnetic coil array layer, and the micro-channel layer is used for fluid circulation. The electromagnetic coil array layer is arranged below the micro-channel layer, a permanent magnet moving space is reserved between the micro-channel layer and the electromagnetic coil array layer, and at least one permanent magnet is arranged in the permanent magnet moving space. The electromagnetic coil array layer comprises a plurality of electromagnetic coil units, and an electromagnetic field is generated by controlling the on-off of each electromagnetic coil unit so as to provide power for the movement of the permanent magnet. According to the microfluid electromagnetic array chip, automation of microfluid liquid drops is achieved by controlling the electromagnetic array and the permanent magnet, the operation efficiency can be improved, operation is rapid, and accurate control can be achieved.

Description

Technical Field

[0001] The invention relates to the field of microfluidic technology, in particular to a microfluidic electromagnetic array chip and an automated microfluidic electromagnetic array manipulation system. Background Art

[0002] As an important interdisciplinary subject, microfluidics technology integrates knowledge from multiple disciplines such as micro-nano processing technology, physics, chemistry and biology, and has been widely used in biomedicine, chemical analysis, environmental monitoring, drug development and other fields. Microfluidics technology, with its characteristics of operating tiny fluids at a microscale, provides a powerful tool for achieving high-throughput, high-sensitivity and low-cost analysis and detection.

[0003] Traditional microfluidic manipulation techniques mainly include electric field, pressure and surface tension. However, these methods have some limitations in some cases. For example, electric field manipulation requires electrolytes in the sample and is not suitable for samples without electrolytes; pressure-driven manipulation may damage the microfluidic structure and is not suitable for high-viscosity liquids; surface tension manipulation has poor accuracy and is not suitable for high-precision operations. How to achieve automated and precise manipulation of tiny droplets while avoiding interference with the microfluidic structure is an important issue.

[0004] In view of the above problems, the present invention aims to provide a microfluidic electromagnetic array chip, a preparation method thereof and an automated microfluidic electromagnetic array manipulation system. By combining microfluidic technology and electromagnetic array control technology, the limitations of traditional microfluidic manipulation technology are overcome, and automated and precise manipulation of tiny droplets is achieved. The microfluidic electromagnetic array manipulation system has broad application prospects. In the biomedical field, it can be used for cell manipulation, protein analysis, etc.; in the field of chemical analysis, it can be used for the construction of microreactors and high-throughput drug screening; in the field of environmental monitoring, it can be used for the detection and monitoring of micropollutants. In addition, the system can also be applied to the design and manufacture of microfluidic devices such as microfluidic chips and laboratories. Summary of the invention

[0005] In view of the deficiencies of the prior art described above, the purpose of the present invention is to provide a microfluidic electromagnetic array chip and an automated microfluidic electromagnetic array manipulation system, which realizes the automation of microfluidic droplets by controlling the electromagnetic array and the permanent magnet, thereby improving the operating efficiency, and the operation is fast and accurate.

[0006] In order to achieve the above-mentioned and other related purposes, the first invention of the present invention provides a microfluidic electromagnetic array chip, wherein the chip at least comprises a microchannel layer and an electromagnetic coil array layer;

[0007] The microchannel layer is used for fluid circulation; the electromagnetic coil array layer is arranged below the microchannel layer, and a permanent magnet moving space is reserved between the microchannel layer and the electromagnetic coil array layer, and the permanent magnet moving space is provided with at least one permanent magnet;

[0008] The electromagnetic coil array layer includes a plurality of electromagnetic coil units; wherein, an electromagnetic field is generated by controlling the on and off of each electromagnetic coil unit to provide power for the movement of the permanent magnet.

[0009] In some specific examples, the electromagnetic coil unit includes a plurality of layer coil units stacked vertically; each layer coil unit is provided with a coil, the coil is arranged in turns in the plane of the layer, and each layer coil unit is connected in series through a connecting column;

[0010] The electromagnetic coil array includes a PCB board, which is provided with a plurality of supporting plates, the number of layers of the supporting plates being the same as the number of layers of the layer coil units; each layer coil unit is respectively placed on each layer of the supporting plates, and the wires in the PCB board are used to supply power to the electromagnetic coil units.

[0011] In some specific examples, the polarization direction of the permanent magnet is the same as the stacking direction of the multi-layer coil units.

[0012] In some specific examples, the electromagnetic coil unit includes an upper layer coil unit and a lower layer coil unit which are vertically stacked; the upper layer coil unit is provided with an upper layer coil, and the upper layer coil is arranged in turns from the periphery to the center in sequence, the coil end at the periphery is connected to the wire in the PCB board, and the coil end at the center is connected to the upper end of the connecting column;

[0013] The lower coil unit is provided with a lower coil, which is arranged in turns from the periphery to the center in sequence, the coil end at the periphery is connected to the wire in the PCB board, and the coil end at the center is connected to the lower end of the connecting column.

[0014] In some specific examples, the coil is arranged in turns in the plane of the layer, and the number of turns is 4 to 15 turns; and / or the width of the coil is 0.05 to 0.15 mm.

[0015] In some specific examples, the coils of the layer coil unit are arranged in turns in a square shape within the plane of the layer, and the side length of the square is 1 to 5 mm.

[0016] In some specific examples, the plurality of electromagnetic coil units are distributed in an array on the electromagnetic coil array layer.

[0017] In some specific examples, the array distribution is selected from one of an 8x8 array, a 16x16 array, or a 32x32 array.

[0018] In some specific examples, the permanent magnet is a neodymium iron boron (NdFeB) permanent magnet; and / or the permanent magnet has a diameter of 3 to 5 mm, a height of 0.5 to 1 mm, a relative magnetic permeability of 1.00 to 1.12, and a residual magnetic flux density of 1.35 to 1.55 T.

[0019] In some specific examples, the microchannel layer is a planar structure for fluid circulation; or the microchannel is provided with microfluidic channels for fluid circulation.

[0020] The second aspect of the present application provides an automated microfluidic electromagnetic array manipulation system, comprising the microfluidic electromagnetic array chip as described above, and also comprising an electromagnetic coil on-off unit, a logic control unit connected to the electromagnetic coil on-off unit signal, and a human-computer interaction unit; each of the electromagnetic coil units is electrically connected to the magnetic coil on-off unit, and the human-computer interaction unit is signal-connected to the logic control unit.

[0021] The microfluidic electromagnetic array chip provided by the present invention has the following beneficial effects:

[0022] 1) High manipulation efficiency: Through the control of electromagnetic arrays and permanent magnets, the microfluidic droplets can be manipulated automatically, quickly and accurately, which can improve the operation efficiency;

[0023] 2) Strong activity: The layout of the electromagnetic array and the structure of the microfluidic chip can be adjusted according to different experimental requirements, which has high flexibility;

[0024] 3) Non-invasive: Avoids interference with the microfluidic structure and reduces droplet damage and sample contamination during manipulation;

[0025] 4) Multi-field application: This technology can be applied in various fields, especially in biological detection, and has broad application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 Schematic diagram of the structure of the electromagnetic coil unit of the microfluidic electromagnetic array chip in Example 1 of the present invention.

[0027] Figure 2 Schematic diagram of the structure of the electromagnetic coil array layer of the microfluidic electromagnetic array chip in Example 1 of the present invention.

[0028] Figure 3 This is a schematic diagram of the overall structure of the microfluidic electromagnetic array chip in Example 1 of the present invention. (The microchannel layer is transparently displayed)

[0029] Figure 4 1 is a top view of the microfluidic electromagnetic array chip in Example 1 of the present invention.

[0030] Figure 5This is a side view of the microfluidic electromagnetic array chip in Example 1 of the present invention.

[0031] Figure 6 ComsolMultiphysics simulation diagram of magnetic field strength and gradient with and without permanent magnets placed in the permanent magnet moving space.

[0032] Figure 7 Schematic diagram of the structure of the electromagnetic coil unit of the microfluidic electromagnetic array chip in Example 2 of the present invention.

[0033] Figure 8 1 is a top view of the electromagnetic coil unit of the microfluidic electromagnetic array chip in Example 2 of the present invention.

[0034] Fig. 9 1 is a side view of the electromagnetic coil unit of the microfluidic electromagnetic array chip in Example 2 of the present invention.

[0035] Fig.10 It is a schematic diagram of the magnetic field strength induced after the Comsol Multiphysics simulation coil unit of Example 2 of the present invention is powered on.

[0036] Description of reference numerals:

[0037] 1 Microchannel layer

[0038] 2 Electromagnetic coil array layer

[0039] 21 Solenoid coil unit

[0040] 211 Connecting column

[0041] 212 Upper layer coil unit

[0042] 213 Lower layer coil unit

[0043] 3 permanent magnets

[0044] 4 Magnetic coil on / off unit

[0045] 5 Magnetic beads

[0046] 6 Communication Interface

[0047] D Coil width DETAILED DESCRIPTION

[0048] The design principle of the present invention is: when the magnetic droplets are located in the microfluidic electromagnetic array chip, by adjusting the current passed into the electromagnetic coil array, an induced magnetic field can be generated at a specific position, thereby providing the necessary power and positioning accuracy for the movement of the permanent magnet. The magnetic particles in the droplets in the microchannel layer above the electromagnetic coil array layer will be attracted by the superimposed magnetic field, so that the movement of the permanent magnet can drive the movement of the magnetic droplets above, thereby indirectly and accurately controlling the droplets. Based on the above-mentioned research and development principles, the inventor has designed and provided a technical solution that integrates microfluidic technology and electromagnetic array control, and aims to achieve automatic, rapid and precise manipulation of microfluidic droplets through careful design and optimization. On this basis, the present invention has been completed.

[0049] The beneficial effects of the present invention are further illustrated below in conjunction with embodiments.

[0050] In order to make the invention purpose, technical scheme and beneficial technical effect of the present invention clearer, the present invention is further described in detail below in conjunction with examples. However, it should be understood that the examples of the present invention are only for explaining the present invention, not for limiting the present invention, and the examples of the present invention are not limited to the examples given in the specification. The specific experimental conditions or operating conditions not specified in the examples are made under conventional conditions, or are made under the conditions recommended by the material supplier.

[0051] In addition, it should be understood that one or more method steps mentioned in the present invention do not exclude the existence of other method steps before or after the combination step or the insertion of other method steps between these explicitly mentioned steps, unless otherwise specified; it should also be understood that the combination connection relationship between one or more devices / apparatuses mentioned in the present invention does not exclude the existence of other devices / apparatuses before or after the combination device / apparatus or the insertion of other devices / apparatuses between these explicitly mentioned two devices / apparatuses, unless otherwise specified. Moreover, unless otherwise specified, the numbering of each method step is only a convenient tool for identifying each method step, and is not intended to limit the order of arrangement of each method step or the scope of the present invention. Changes or adjustments in their relative relationships should also be regarded as the scope of the present invention without substantially changing the technical content.

[0052] In the following examples, the reagents, materials and instruments used are all commercially available unless otherwise specified.

[0053] Example 1

[0054] See also Figures 1 to 5The microfluidic electromagnetic array chip at least includes a microchannel layer 1 and an electromagnetic coil array layer 2, wherein the microchannel layer 1 is used for fluid circulation. The electromagnetic coil array layer 2 is arranged below the microchannel layer 1, and a permanent magnet moving space is left between the microchannel layer 1 and the electromagnetic coil array layer 2, wherein at least one permanent magnet 3 is arranged in the permanent magnet moving space. The electromagnetic coil array layer 2 includes a plurality of electromagnetic coil units 21, wherein an electromagnetic field is generated by controlling the on and off of each electromagnetic coil unit 21, thereby providing power for the movement of the permanent magnet 3.

[0055] Specifically, in terms of the arrangement of the array of electromagnetic coil units, the number and arrangement of the electromagnetic coil units are accurately calculated according to the size and shape of the microfluidic electromagnetic array chip to maximize the uniformity and strength of the magnetic field. The layout of the electromagnetic coils is optimized, and the number and arrangement of the coils can be adjusted as needed, such as 8x8, 16x16 size, etc. These electromagnetic coils are connected to the power supply through a control system to achieve accurate regulation of current and frequency. The control system can use a microprocessor, a sensor and feedback control technology to monitor and adjust the strength and direction of the electromagnetic field in real time. In this way, a strong and controllable magnetic field can be generated in the electromagnetic coil array layer, providing the necessary power and positioning accuracy for droplet manipulation. In addition, the permanent magnet on the electromagnetic coil array layer 2 can also play a role in enhancing the electromagnetic field. By placing a permanent magnet above the electromagnetic coil array layer 2, the strength and direction of the electromagnetic field can be increased. A permanent magnet is a magnet that generates a stable magnetic field, which can continuously generate a magnetic field in the absence of an external current. When placed above the electromagnetic coil array layer 2, the magnetic field generated by the permanent magnet interacts with the magnetic field generated by the electromagnetic coil, thereby enhancing the overall magnetic field strength. By adjusting the position and orientation of the permanent magnet, the distribution and shape of the magnetic field can be precisely controlled, achieving more precise manipulation and automated positioning of the droplets. The magnetic field generated by the permanent magnet interacts with the magnetic field generated by the electromagnetic coil, thereby enhancing the overall magnetic field strength. Figure 6 ,from Figure 6 It can be seen that when the permanent magnet exists, the strength and gradient of the magnetic field after the combination of the coil and the permanent magnet are very large, while when the permanent magnet does not exist, the magnetic field strength of the coil differs by about three orders of magnitude.

[0056] In a specific example, the electromagnetic coil unit 21 includes a plurality of vertically stacked coil units (the vertical direction is specifically Figure 1 The electromagnetic coil array includes a PCB board 22, which is provided with a plurality of support plates, and the number of support plates is the same as the number of coil units. The coil units of each layer are respectively placed on the support plates of each layer, and the wires in the PCB board 22 are used to supply power to the electromagnetic coil units 21.

[0057] Specifically, current is passed through each layer of coil units connected in series, for example, current is input from the first layer and current is output from the last layer. At this time, the direction of the magnetic field can be determined by the right-hand rule, and the electromagnetic coil can be equivalent to an electromagnet. Of course, the magnetic field size can be adjusted by controlling the number of turns in the vertical direction of the layers of vertically stacked coil units, or the number of turns in the horizontal direction of the surrounding coils of each layer of coil units, as well as the current size.

[0058] In a specific example, the polarization direction of the permanent magnet 3 is the same as the stacking direction of the multi-layer coil unit, that is, the polarization direction of the permanent magnet 3 is the Z-axis direction. The magnetic field generated by the permanent magnet interacts with the magnetic field generated by the electromagnetic coil, thereby enhancing the overall magnetic field strength.

[0059] In one specific example, see Figure 1 The electromagnetic coil unit 21 includes an upper coil unit 212 and a lower coil unit 213 which are vertically stacked. The upper coil unit 212 is provided with an upper coil, which is arranged in turns from the periphery to the center, the coil at the periphery is connected to the wire in the PCB board, and the coil end at the center is connected to the upper end of the connecting column 211. The lower coil unit 213 is provided with a lower coil, which is arranged in turns from the periphery to the center, the coil at the periphery is connected to the wire in the PCB board, and the coil end at the center is connected to the lower end of the connecting column 211.

[0060] In a specific example, the coil is arranged in turns in the plane of the layer, the number of turns is 4 to 15 turns, and in this example, it is set to 6 turns. The width of the coil is 0.05 to 0.15 mm, such as 0.05 to 0.1 mm or 0.1 to 0.15 mm.

[0061] In a specific example, the coils of the layer coil unit are arranged in turns in a square shape within the plane of the layer, and the side length of the square is 1-5 mm, such as 1-2 mm, 2-3 mm or 3-5 mm.

[0062] In one specific example, see Figure 2 The plurality of electromagnetic coil units 21 are distributed in an array on the electromagnetic coil array layer 2. For example, the array distribution is selected from one of an 8x8 array, a 16x16 array or a 32x32 array, and in this example, a 16x16 array is selected.

[0063] In a specific example, the permanent magnet 3 is a neodymium iron boron NdFeB permanent magnet with a diameter of 3 to 5 mm, a height of 0.5 to 1 mm, a relative magnetic permeability of 1.00 to 1.12, and a residual magnetic flux density of 1.35 to 1.55T.

[0064] In a specific example, the microchannel layer 1 is a planar structure for fluid circulation, that is, the microchannel layer 1 is a flat area, rather than a traditional closed channel and chamber structure. Such a design makes it easier for droplets to move freely and manipulate under an electromagnetic field. During the preparation process, the smoothness of the channel and the defect-free surface are ensured to avoid adhesion and damage of droplets during manipulation. In addition, the material selection of the chip needs to have excellent corrosion resistance and biocompatibility to meet the needs of different application scenarios, such as PDMS.

[0065] Example 2

[0066] This example provides a specific microfluidic electromagnetic array chip:

[0067] 1) Permanent magnet 3: 3.8mm in diameter, 0.8mm in height, made of N52, with a relative magnetic permeability of 1.05, a residual magnetic flux density of 1.45T, and a polarization direction of the Z axis. N52 permanent magnets are selected as a static magnetic field source to enhance the magnetic force. N52 refers to a grade of neodymium iron boron (NdFeB) permanent magnets, which are a material with persistent magnetism that can generate and maintain a magnetic field without an external electric field or current.

[0068] 2)PCB-electromagnetic coil array layer 2:

[0069] The PCB board adopts a 4-layer PCB board structure, and the electromagnetic coil unit 21 includes 3 layers of coil units stacked vertically. The coil distribution of the electromagnetic coil unit 21 is as follows: Figures 7 to 9 As shown, dense spiral coils are formed by PCB routing, and holes are punched between each layer of coils through existing processes and connected in series through connecting pillars 211. Figure 7 , set the current to flow in from the front of the PCB board and out from the back, similar to a three-layer solenoid. At this time, the direction of the magnetic field can be determined by the right-hand rule, and the electromagnetic coil can be equivalent to an electromagnet. The size of the induced electromagnetic field can be adjusted by controlling the number of coil turns, coil size, and current size.

[0070] Specifically, see Figure 8 , the PCB trace width D (i.e. coil width D) is 0.1mm, and the coil setting square size is: 2.737mm x 2.737mm. Fig.10 Comsol Multiphysics was used to simulate the magnetic field strength induced by the coil unit after it was powered on. From the top view, the magnetic field increases from the edge to the center, with a maximum value of nearly 35×10 -4 T. Observe the distribution of the induced magnetic field at the section parallel to the xy plane 1 mm above the coil in the Z-axis direction. It can be seen that the magnetic field is distributed in a circular shape and is relatively uniform.

[0071] 3) Arraying In terms of the layout of the electromagnetic coil array, the number and arrangement of coils can be adjusted as needed, such as 8x8, 16x16, etc. Since the row and column control are both 2 pieces of 16-way multiplexer ICs, the current maximum support is 32x32, which can be expanded as needed. These electromagnetic coils are connected to the power supply through the control system to achieve precise adjustment of current and frequency. In this way, a precisely controllable magnetic field can be generated on the PCB bottom plate, providing the necessary power and positioning accuracy for the movement of the permanent magnet. The movement of the permanent magnet can also drive the movement of the magnetic droplets above, thereby indirectly and accurately controlling the droplets.

[0072] For PCB preparation, we use drawing board tools such as AD to design, submit gerber files to the foundry for production, and test after completion. The test concluded that when the current I=100mA is passed, the induced electromagnetic field is about 0.3mT, which can drive a permanent magnet with a diameter of 3.8mm. When I=200mA, the induced electromagnetic field is about 0.5mT, and the permanent magnet can be driven to move more stably.

[0073] Example 3

[0074] This example provides an automated microfluidic electromagnetic array manipulation system including the microfluidic electromagnetic array chip as described above, and also includes an electromagnetic coil on-off unit 4, a logic control unit and a human-machine interaction unit connected to the electromagnetic coil on-off unit 4 by signal, each electromagnetic coil unit 21 is electrically connected to the magnetic coil on-off unit 4, and the human-machine interaction unit is connected to the logic control unit by signal. The electromagnetic coil on-off unit 4 is a row-column chip integrated on the PCB, by connecting the logic control unit (MCU controller) to the row-column chip, for example, connecting the MCU controller to the row-column chip from the communication interface 6, giving instructions to the logic control unit through the human-machine interaction unit, and the logic control unit sends instructions to select the corresponding electromagnetic coil unit 21 through the row-column chip, and the coil is energized to attract the permanent magnet to move. Of course, a fixed program can also be set to allow the permanent magnet to move along a fixed route.

[0075] The general usage of the microfluidic electromagnetic array core is as follows: magnetic particles are added to the droplets to make the droplets manipulable, and then the magnetic droplets are injected into the microchannel layer. The magnetic control system is connected through an external MCU controller, and instructions are issued to select the corresponding coils through the row and column chips. The coils are energized to attract the permanent magnets to move, and vice versa, the permanent magnets do not move, which also corresponds to the movement of the magnetic droplets above. Based on this principle, a fixed program is set to allow the permanent magnets to move along a fixed route, that is, the automatic manipulation of droplets. If the operation is complex and there are many processes, permanent magnets can be added and corresponding partitions can be set. Different permanent magnets are responsible for the operation of the corresponding areas. After completing a series of operations, the reacted droplets can be subjected to subsequent experimental tests and evaluations.

[0076] It is worth noting that when microfluidic droplets contain magnetic particles, a strong magnetic field can be generated at a specific location by adjusting the current and frequency of the electromagnetic coil array. The magnetic particles are affected by the magnetic field, thereby achieving the positioning and manipulation of the droplets. By precisely controlling the strength and direction of the electromagnetic array, multiple microfluidic droplets can be merged into larger droplets, or large droplets can be separated into small droplets, achieving complex droplet operations. That is, this technology can be applied to various fields, especially in biological detection, and has broad application prospects.

[0077] The above embodiments are merely illustrative of the principles and effects of the present application and are not intended to limit the present application. Anyone familiar with the technology may modify or change the above embodiments without violating the spirit and scope of the present application. Therefore, all equivalent modifications or changes made by a person of ordinary skill in the art without departing from the spirit and technical ideas disclosed in the present application shall still be covered by the claims of the present application.

Claims

1. A microfluidic electromagnetic array chip, It is characterized in that The chip comprises at least a microchannel layer (1) and an electromagnetic coil array layer (2); The microchannel layer (1) is used for fluid circulation; The electromagnetic coil array layer (2) is arranged below the microchannel layer (1), and a permanent magnet moving space is reserved between the microchannel layer (1) and the electromagnetic coil array layer (2), and at least one permanent magnet (3) is arranged in the permanent magnet moving space; The electromagnetic coil array layer (2) comprises a plurality of electromagnetic coil units (21); The electromagnetic field is generated by controlling the on and off of each electromagnetic coil unit (21), thereby providing power for the movement of the permanent magnet (3).

2. The fluid electromagnetic array chip according to claim 1, It is characterized in that The electromagnetic coil unit (21) comprises a plurality of layer coil units stacked vertically; each layer coil unit is provided with a coil, the coil is arranged in turns in the plane of the layer, and each layer coil unit is connected in series via a connecting column (211); The electromagnetic coil array comprises a PCB board (22), wherein the PCB board (22) is provided with a plurality of layers of support boards, and the number of layers of the support boards is the same as the number of layers of the layer coil units; Each layer of coil units is placed on each layer of support plates respectively, and the wires in the PCB board (22) supply power to the electromagnetic coil units (21).

3. The fluid electromagnetic array chip according to claim 1, It is characterized in that The polarization direction of the permanent magnet (3) is the same as the superposition direction of the multi-layer coil units.

4. The fluid electromagnetic array chip according to claim 2, It is characterized in that The electromagnetic coil unit (21) comprises an upper layer coil unit (212) and a lower layer coil unit (213) which are vertically stacked; The upper layer coil unit (212) is provided with an upper layer coil, which is arranged in turns from the periphery to the center in sequence, the coil end at the periphery is connected to the wire in the PCB board, and the coil end at the center is connected to the upper end of the connecting column (211); The lower layer coil unit (213) is provided with a lower layer coil, which is arranged in turns from the periphery to the center in sequence, the coil end at the periphery is connected to the wire in the PCB board, and the coil end at the center is connected to the lower end of the connecting column (211).

5. The fluid electromagnetic array chip according to claim 2, It is characterized in that The coil is arranged in turns in the plane of the layer, and the number of turns is 4 to 15; and / or the width of the coil is 0.05 to 0.15 mm; And / or, the coils of the layer coil unit are arranged in turns in a square shape within the plane of the layer, and the side length of the square is 1 to 5 mm.

6. The fluid electromagnetic array chip according to claim 1, It is characterized in that A plurality of electromagnetic coil units (21) are distributed in an array on the electromagnetic coil array layer (2).

7. The fluid electromagnetic array chip according to claim 6, It is characterized in that The array distribution form is selected from one of an 8x8 array, a 16x16 array or a 32x32 array.

8. The fluid electromagnetic array chip according to claim 1, It is characterized in that The permanent magnet (3) is a neodymium iron boron (NdFeB) permanent magnet; and / or the permanent magnet has a diameter of 3 to 5 mm, a height of 0.5 to 1 mm, a relative magnetic permeability of 1.00 to 1.12, and a residual magnetic flux density of 1.35 to 1.55 T.

9. The fluid electromagnetic array chip according to claim 1, It is characterized in that The microchannel layer (1) is a planar structure for fluid circulation; or the microchannel is provided with microfluidic channels for fluid circulation.

10. An automated microfluidic electromagnetic array manipulation system, It is characterized in that A microfluidic electromagnetic array chip comprising any one of claims 1 to 9; It also includes an electromagnetic coil on-off unit (4), a logic control unit connected to the electromagnetic coil on-off unit (4) by signal, and a human-machine interaction unit; Each of the electromagnetic coil units (21) is electrically connected to the magnetic coil on-off unit (4), and the human-machine interaction unit is signal-connected to the logic control unit.

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