Cleaning device and biochemical substance analysis system

Abstract

The invention discloses a cleaning device and a biochemical substance analysis system.The cleaning device comprises a shell, a liquid taking assembly, a fluid storage assembly and a moving assembly, and a containing cavity is formed in the shell and comprises a first containing space and a second containing space; the fluid storage assembly is movably arranged in the first accommodating space, the liquid taking assembly is movably arranged in the second accommodating space, and the liquid taking assembly comprises a reagent needle; the moving assembly is connected with the liquid taking assembly and is used for driving the liquid taking assembly to move, so that the reagent needle extends into or retreats from the fluid storage assembly. According to the biochemical substance analysis system, by adopting the cleaning device, the automatic cleaning function after the biochemical substance analysis system is discharged from the machine can be realized, the convenience and the automation degree are improved, the cleaning steps are simple, and the cleaning device is simple in structure; in addition, in the process of longer read length sequencing, the volume of the required reagent can be expanded.

Description

Technical Field

[0001] The present application relates to the technical field of biochemical substance analysis, and in particular to a cleaning device and a biochemical substance analysis system. Background Art

[0002] In the gene sequencing process, cleaning the instrument pipelines in the sequencer after it is off the machine is a key operation step. After the sequencing of existing sequencers, users are required to manually clean the instrument pipelines, replace various cleaning reagent tanks, and use cleaning tools other than the sequencer to clean the instrument pipelines. The operation convenience and automation of the equipment are poor. Summary of the invention

[0003] In order to solve at least one of the above defects, it is necessary to propose a cleaning device, which can realize automatic cleaning of the biochemical substance analysis system, which is conducive to improving the convenience of operation and the degree of automation.

[0004] In addition, an embodiment of the present application also provides a biochemical substance analysis system using the cleaning device.

[0005] In a first aspect, an embodiment of the present application provides a cleaning device, which comprises: a shell, a liquid collection component, a fluid storage component and a moving component, wherein the shell forms a accommodating chamber, the accommodating chamber comprises a first accommodating space and a second accommodating space located above the first accommodating space; the fluid storage component is movably disposed in the first accommodating space, and the fluid storage component is used to store fluid; the liquid collection component is movably disposed in the second accommodating space, and the liquid collection component comprises a reagent needle; the moving component is disposed on the outside of the shell and is connected to the liquid collection component, wherein the moving component is used to drive the liquid collection component to move toward or away from the fluid storage component so that the reagent needle extends into or exits the fluid storage component.

[0006] In some possible embodiments, the liquid collection component includes: a guide rail component arranged in the second accommodating space, and a reagent needle fixing plate arranged on the guide rail component, and the reagent needle is arranged on the reagent needle fixing plate; wherein the moving component is connected to the reagent needle fixing plate, and is used to drive the reagent needle fixing plate to move on the guide rail assembly toward or away from the fluid storage component, so as to drive the reagent needle to extend into or out of the fluid storage component.

[0007] In some possible embodiments, the guide rail assembly includes: a guide rail fixing plate, a first guide rail arranged on the guide rail fixing plate, and a slider arranged on the first guide rail, and the reagent needle fixing plate is arranged on the slider.

[0008] In some possible embodiments, the guide rail assemblies are provided in multiple groups, and the multiple groups of guide rail assemblies are arranged on the periphery of the reagent needle fixing plate.

[0009] In some possible embodiments, the moving assembly includes: a moving part located outside the shell and connected to the reagent needle fixing plate, and a locking mechanism provided on the moving part, wherein the locking mechanism is used to lock or unlock the moving part.

[0010] In some possible embodiments, the locking mechanism includes: a fixing member provided on the moving component, an elastic member provided on the fixing member, a locking shaft provided at one end of the elastic member, and a buckle provided on the locking shaft;

[0011] The shell is respectively provided with a first locking hole and a second locking hole at both ends of the moving path corresponding to the moving part; the elastic member is used to push the locking shaft to pop out and extend into the first locking hole or the second locking hole; the buckle is used to push the locking shaft to withdraw from the first locking hole or the second locking hole under the action of external force, and compress the elastic member.

[0012] In some possible embodiments, the fixing member includes a first wall close to the first locking hole and the second locking hole, a second wall away from the first locking hole and the second locking hole, and a connecting wall connecting the first wall and the second wall; the locking shaft is movably arranged through the first wall and the second wall, and one end of the locking shaft close to the first wall extends out of the movable part; the buckle is arranged on the locking shaft between the first wall and the second wall, and is arranged close to the first wall, and the elastic member is sleeved on the locking shaft and is located between the buckle and the second wall.

[0013] In some possible embodiments, the fluid storage assembly includes: a second guide rail arranged in the first receiving space, a receiving groove arranged on the second guide rail, a container arranged in the receiving groove, and a container fixing plate for fixing the container, and the receiving groove can be moved along the second guide rail to move out of or into the first receiving space.

[0014] In some possible embodiments, the container includes at least one of a reagent bottle, a cleaning liquid bottle, a waste liquid bottle, and an exhaust bottle.

[0015] In a second aspect, an embodiment of the present application further provides a biochemical substance analysis system, which includes a fluid use module and a cleaning device as described in the first aspect, wherein the fluid use module is connected to the reagent needle.

[0016] The biochemical substance analysis system provided in the embodiment of the present application can realize the automatic cleaning function after the machine is removed by adopting the aforementioned cleaning device, without any human intervention during the period, which greatly improves the convenience and automation level, and the cleaning steps are simple, and the cleaning device has a simple structure, which solves the user pain point that the previous product cleaning requires the use of multiple instruments and the cleaning steps are cumbersome. In addition, the aforementioned cleaning device can also realize the capacity amplification demand of the corresponding increase in the required reagent loading during the longer read length sequencing of the biochemical substance analysis system. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments of the present application will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0018] Figure 1 This is a system framework diagram of a biochemical substance analysis system according to an embodiment of the present application.

[0019] Figure 2 It is a schematic structural diagram of a cleaning device according to an embodiment of the present application.

[0020] Figure 3 for Figure 2 Schematic diagram of the structure of the cleaning device without part of the shell.

[0021] Figure 4 for Figure 2 Exploded diagram.

[0022] Figure 5 for Figure 3 Schematic diagram of the structure of the liquid extraction component.

[0023] Figure 6 for Figure 5 Enlarged view of part A.

[0024] Figure 7 for Figure 3 Schematic diagram of the structure of the mobile components.

[0025] Figure 8 for Figure 7 A structural diagram of another perspective of the mobile component.

[0026] Fig. 9 For Figure 7 Schematic diagram of the structure of the moving parts.

[0027] Fig.10 for Figure 7 Schematic diagram of the structure of the middle locking mechanism.

[0028] Fig.11 For the general Figure 3 Schematic diagram of the structure of extracting the first accommodating space from the fluid storage component.

[0029] Main component symbols

[0030]

[0031]

[0032] The following specific implementation methods will further illustrate the present application in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0033] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0034] It should be noted that when a component is referred to as being "fixed to" or "mounted on" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "set on" another component, it may be directly set on the other component or there may be a central component at the same time. The term "and / or" as used herein includes all and any combinations of one or more of the relevant listed items.

[0035] See also Figure 1 The embodiment of the present application provides a biochemical substance analysis system 1000, which can be, for example, a gene sequencing system, and can implement gene sequencing steps including sample loading, biochemical reaction, and fluid pipeline cleaning. The biochemical substance analysis system 1000 can include a fluid use module 200 and a cleaning device 100, wherein the cleaning device 100 is connected to the fluid use module 200, and can automatically clean the fluid pipeline, flow pool, and fluid transfer device in the fluid use module 200.

[0036] See also Figure 2 and Figure 3As shown, the cleaning device 100 provided in the embodiment of the present application includes: a shell 1, a liquid collection component 2, a fluid storage component 3 and a moving component 4. The shell 1 forms a accommodating chamber 11, and the accommodating chamber 11 includes a first accommodating space 12 and a second accommodating space 13 located above the first accommodating space 12. The liquid collection component 2 is movably arranged in the second accommodating space 13, and the liquid collection component 2 includes a reagent needle 21. The liquid collection component 2 can move along the first direction a. Specifically, when the first accommodating space 12 and the second accommodating space 13 are stacked up and down, the first direction a is a vertical direction, that is, the liquid collection component 2 can move in the vertical direction. The fluid storage component 3 is movably arranged in the first accommodating space 12, and the fluid storage component 3 is used to store fluid, and the fluid here can include reagents, cleaning fluids, gases, etc. Specifically, the fluid storage component 3 can also move along the second direction b perpendicular to the first direction a, that is, the fluid storage component 3 can move in the horizontal direction, so as to facilitate the fluid storage component 3 to be pulled out or pushed into the first accommodating space 12 in the shell 1 to achieve the replacement of the fluid storage component 3. The moving component 4 is connected to the liquid collection component 2, and is used to drive the liquid collection component 2 to move toward or away from the fluid storage component 3, that is, to move along the first direction a, so that the reagent needle 21 extends into or exits the fluid storage component 3 to achieve the purpose of extracting fluid.

[0037] Please refer to Figure 4 As shown, the shell 1 includes an outer shell 14, an upper cover 15 and a base 16, and the outer shell 14, the upper cover 15 and the base 16 together enclose a receiving chamber 11 with an opening, and a first cover plate 17 and a second cover plate 18 are provided at the opening of the receiving chamber 11. The first cover plate 17 is movably arranged at the opening corresponding to the first receiving space 12, and is connected to the fluid storage component 3, so as to pull the fluid storage component 3 out of or push it into the first receiving space 12. The second cover plate 18 is arranged at the opening corresponding to the second receiving space 13, wherein the moving component 4 is movably arranged through the second cover plate 18, one end of which extends out of the outside of the second cover plate 18, and the other end of which extends into the second cover plate 18 and is connected to the liquid collection component 2, and the moving component 4 can move relative to the second cover plate 18 along the first direction a (for example, the vertical direction) to drive the liquid collection component 2 to move up and down.

[0038] In some embodiments, the housing 1 is a substantially cubic structure, and the first cover plate 17 and the second cover plate 18 are located on the same side, so as to facilitate the assembly of the cleaning device 100 with other instruments and the operation of the cleaning device 100 .

[0039] In some embodiments, the shell 1 also includes a partition 19, which is located in the accommodating chamber 11 and divides the accommodating chamber 11 into the first accommodating space 12 and the second accommodating space 13, wherein the reagent needle 21 is movably arranged through the partition 19, so that when the liquid collection component 2 is moved, the reagent needle 21 can be extended into the fluid storage component 3 to extract the reagent.

[0040] Please refer to Figures 4 to 6 As shown, the liquid taking component 2 includes: a guide rail component 22 arranged in the second accommodating space 13, and a reagent needle fixing plate 23 arranged on the guide rail component 22, and the reagent needle 21 is arranged on the reagent needle fixing plate 23. Specifically, the guide rail component 22 is fixed on the partition 19. Wherein, the moving component 4 is connected with the reagent needle fixing plate 23, and is used to drive the reagent needle fixing plate 23 to move along the first direction a on the guide rail component 22, so as to drive the reagent needle 21 to extend into or exit the fluid storage component 3, so as to realize the reagent extraction. Specifically, the number of reagent needles 21 can be multiple, so as to realize the extraction of different cleaning reagents. The top of the reagent needle 21 can be connected with the fluid use module 200 through a fluid pipeline (not shown), so as to increase reagents, cleaning fluids, etc. for the fluid use module 200, and the waste liquid of the cleaning fluid use module 200 can also be recycled into the fluid storage component 3, so as to realize the automatic liquid addition and automatic cleaning of the fluid use module 200.

[0041] In some embodiments, the guide rail assembly 22 is vertically fixed on the partition 19 so that the reagent needle fixing plate 23 can drive the reagent needle 21 to move in the vertical direction.

[0042] In some embodiments, the number of the guide rail assemblies 22 can be multiple groups, and the multiple groups of the guide rail assemblies 22 are arranged on the periphery of the reagent needle fixing plate 23 to improve the stability of the reagent needle fixing plate 23 when driving the reagent needle 21 to move up and down.

[0043] In some embodiments, the guide rail assembly 22 includes: a guide rail fixing plate 221 disposed on the partition 19, a first guide rail 222 disposed on the guide rail fixing plate 221, and a sliding portion 223 disposed on the first guide rail 222, and the reagent needle fixing plate 23 is disposed on the sliding portion 223.

[0044] In some embodiments, the first guide rail 222 is a linear guide rail.

[0045] In some embodiments, the sliding portion 223 includes a slider 224 slidably disposed on the first guide rail 222, and a first connecting piece 225 and a second connecting piece 226 disposed on the slider 224, the first connecting piece 225 and the second connecting piece 226 being disposed opposite to each other, wherein the first connecting piece 225 is located on the upper surface of the reagent needle fixing plate 23, and the second connecting piece 226 is located on the lower surface of the reagent needle fixing plate 23, so that the first connecting piece 225 and the second connecting piece 226 fix the reagent needle fixing plate 23 on the slider 224. Specifically, the first connecting piece 225 and the second connecting piece 226 are fixed to the reagent needle fixing plate 23 by screws.

[0046] In some embodiments, the reagent needle fixing plate 23 is roughly a rectangular structure, and one end of multiple reagent needles 21 is fixed on the reagent needle fixing plate 23, and then the up and down movement of the reagent needle fixing plate 23 can realize the rise and fall of multiple reagent needles 21. Multiple groups of guide rail assemblies 22 are arranged around the reagent needle fixing plate 23 of rectangular structure, so as to realize the stable lifting of the reagent needle 21. Specifically, two groups of guide rail assemblies 22 are respectively arranged on the two long sides relative to the reagent needle fixing plate 23 to improve the stable lifting of the reagent needle 21. The moving assembly 4 is connected to a short side of the reagent needle fixing plate 23. In order to further improve the stability of the moving assembly 4 when the reagent needle fixing plate 23 is pulled, two groups of guide rail assemblies 22 are arranged on the short side of the reagent needle fixing plate 23. Specifically, these two groups of guide rail assemblies 22 are connected to the reagent needle fixing plate 23 through a connecting plate 24.

[0047] Please refer to Figure 4 and Figure 7 As shown, the moving component 4 includes: a moving part 41 movably provided in the housing 1 and connected to the reagent needle fixing plate 23, and a locking mechanism 42 provided on the moving part 41, wherein the locking mechanism 42 is used to lock the moving part 41 after the reagent needle fixing plate 23 moves into position, so as to fix the liquid collection component 2 in place, so as to prevent the liquid collection component 2 from accidentally moving, affecting the cleaning process, causing accidental injury to the operator, etc. In some embodiments, the moving part 41 is movably provided in the second cover plate 18, one end of which is located on the outside of the second cover plate 18, and one end of which extends into the second cover plate 18 and is connected to the reagent needle fixing plate 23. Specifically, the moving component 4 can be operated manually, and it can be understood that the moving component 4 can also be operated automatically.

[0048] In some embodiments, the movable part 41 includes a pusher 411 and a connecting rod 412, the pusher 411 is located outside the second cover plate 18, one end of the connecting rod 412 extends out of the second cover plate 18 and is connected to the pusher 411, and the other end is connected to the reagent needle fixing plate 23. Specifically, the second cover plate 18 is provided with an opening 182 extending along the first direction a, and the connecting rod 412 is movably arranged in the opening 182, so that the connecting rod 412 can be moved along the opening 182, and therefore, the opening 182 can define the moving path of the movable part 41. In some embodiments, the number of the connecting rod 412 can be two, and the two connecting rods 412 can make the movement of the reagent needle fixing plate 23 more stable.

[0049] In some embodiments, the locking mechanism 42 is disposed at one end of the pusher 411, and the second cover plate 18 has a side wall 181 along the direction of the moving path (i.e., the first direction a), and the top end (i.e., the end away from the first accommodating space 12) of the side wall 181 is provided with a first locking hole 43, and the bottom end (i.e., the end close to the first accommodating space 12) is provided with a second locking hole 44. Specifically, the first locking hole 43 is provided at the upper end (i.e., the end away from the first accommodating space 12) of the opening 182, and the second locking hole 44 is provided at the lower end (i.e., the end close to the first accommodating space 12) of the opening 182. When the pusher 411 moves to the top, the locking mechanism 42 will cooperate with the first locking hole 43 at the top to fix the moving assembly 4. At this time, the fluid storage assembly 3 in the first accommodating space 12 can be pulled out for replacement, and the moving assembly 4 can be fixed, which can prevent the reagent needle fixing plate 23 from accidentally falling after moving to the top, causing problems such as accidental injury to the operator and damage to the instrument. When the pusher 411 moves to the bottom, the locking mechanism 42 cooperates with the second locking hole 44 at the bottom to fix the movable component 4. At this time, the reagent needle 21 extends into the fluid storage component 3 to extract the reagent. Fixing the movable component 4 can prevent the fluid storage component 3 from being accidentally pulled out during the sequencing process, resulting in sequencing failure and damage to the reagent needle 21.

[0050] Please refer to Figures 8 to 10 As shown, the locking mechanism 42 includes: a fixing member 421 provided on the moving component 41, an elastic member 422 provided on the fixing member 421, a locking shaft 423 provided at one end of the elastic member 422, and a buckle 424 provided on the locking shaft 423. The elastic member 422 is used to push the locking shaft 423 to pop out and extend into the first locking hole 43 or the second locking hole 44, and the buckle 424 is used to push the locking shaft 423 to withdraw from the first locking hole 43 or the second locking hole 44 under the action of an external force, and compress the elastic member 422, so as to achieve locking and unlocking of the liquid extraction component 2.

[0051] Specifically, a groove 413 is provided at one end of the pushing member 411 close to the side wall 181, and the fixing member 421 is arranged in the groove 413, and an opening 414 is provided on the end wall of the groove 413. The locking shaft 423 extends from the opening 414 and abuts against the side wall 181 of the second cover plate 18. When the movable part 41 moves to the top, the locking shaft 423 can extend into the first locking hole 43 to achieve top locking of the liquid taking component 2. When the movable part 41 moves to the bottom, the locking shaft 423 extends into the second locking hole 44 to achieve bottom locking of the liquid taking component 2.

[0052] In some embodiments, the fixing member 421 includes a first wall 425 and a second wall 426 that are arranged opposite to each other, and a connecting wall 427 that connects the first wall 425 and the second wall 426. Specifically, the first wall 425, the second wall 426 and the connecting wall 427 form a U-shaped groove structure, the second wall 426 is arranged close to the side wall 181 (or the first locking hole 43 and the second locking hole 44), and the first wall 425 is arranged away from the side wall 181 (or the first locking hole 43 and the second locking hole 44). One end of the locking shaft 423 movably passes through the first wall 425 and can be abutted against the inner wall of the groove 413. The other end of the locking shaft 423 movably passes through the second wall 426 and abuts against the side wall 181 of the second cover plate 18, and can extend into the first locking hole 43 and the second locking hole 44. The buckle 424 is arranged on the locking shaft 423 and is located on the side of the second wall 426 close to the first wall 425. The elastic member 422 is sleeved on the locking shaft 423 and abuts between the first wall 425 and the buckle 424. After the locking shaft 423 pops out, the buckle 424 can be manually pushed to withdraw the locking shaft 423 from the first locking hole 43 or the second locking hole 44. In this way, when the buckle 424 pushes the locking shaft 423 to withdraw from the first locking hole 43 or the second locking hole 44, the elastic member 422 can be compressed to put the elastic member 422 in a compressed state, and then the locking shaft 423 abuts against the side wall 181.

[0053] Please refer to Fig.11 As shown, the fluid storage assembly 3 includes: a second guide rail 31 disposed in the first accommodating space 12, a accommodating groove 32 disposed on the second guide rail 31 and moving in another direction b perpendicular to the first direction a, a container 33 disposed in the accommodating groove 32, and a container fixing plate 34 fixing the container 33. Specifically, a plurality of containers 33 can be placed in the accommodating groove 32, thereby accommodating a variety of fluids. For example, the container 33 can be a reagent bottle, a cleaning liquid bottle, a waste liquid bottle, an exhaust bottle, etc., to hold the reagents and cleaning liquids required for the biochemical reaction, and to recycle the waste liquid, and at the same time, to discharge the liquid in the fluid pipeline, and to empty and dry the cleaned fluid pipeline.

[0054] In some embodiments, the container fixing plate 34 is provided with a through hole 35, and the open end of the container 33 passes through the through hole 35, thereby fixing the container 33 to improve the stability when the reagent needle 21 extracts the reagent. In particular, when multiple containers 33 are placed in the accommodating groove 32, the stability of the multiple containers 33 can be further improved.

[0055] In some embodiments, the first cover plate 17 is connected to the receiving groove 32 , and the receiving groove 32 can be pulled out of or pushed into the first receiving space 12 to achieve the purpose of replacing the container 33 .

[0056] During specific use, the movable component 41 can be manually lifted to drive the reagent needle fixing plate 23 to rise, thereby driving the reagent needle 21 to rise, and the reagent needle 21 withdraws from the container 33 of the fluid storage component 3. When the reagent needle fixing plate 23 moves into place, the locking shaft 423 of the locking mechanism 42 pops out and extends into the first locking hole 43 to fix the reagent needle fixing plate 23. At this time, the accommodating groove 32 can be pulled out and the container 33 can be replaced. After replacing the container 33, manually turn the buckle 424 to withdraw the locking shaft 423 from the first locking hole 43, and manually lower the moving part 41 to move the reagent needle fixing plate 23 downward, so that the reagent needle 21 pierces the sealing film at the opening of the container 33. After reaching the lowermost end, the locking shaft 423 pops out and extends into the second locking hole 44 to fix the reagent needle fixing plate 23. At this time, the reagent needle 21 can absorb reagents or cleaning liquids from the container 33 and provide them to the fluid use module 200, or discharge the waste liquid in the fluid use module 200 into the container 33 containing the waste liquid, so as to complete the automatic liquid addition and automatic cleaning processes of the fluid use module 200. It can be understood that the automatic dry emptying and drying of the fluid pipelines and components in the fluid use module 200 can also be achieved by equipping the biochemical substance analysis system 1000 with corresponding equipment.

[0057] The biochemical substance analysis system 1000 provided in the embodiment of the present application can realize the automatic cleaning function after the machine is removed by adopting the aforementioned cleaning device 100, without any human intervention during the period, which greatly improves the convenience and automation level, and the cleaning steps are simple, and the cleaning device has a simple structure, which solves the user pain point that the previous product cleaning requires the use of multiple instruments and the cleaning steps are cumbersome. In addition, the aforementioned cleaning device 100 can also realize the capacity amplification demand of the corresponding increase in the required reagent loading amount during the longer read length sequencing of the biochemical substance analysis system 1000.

[0058] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present application and are not intended to limit it. Although the present application has been described in detail with reference to the preferred embodiments, a person of ordinary skill in the art should understand that the technical solution of the present application may be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the present application.

Claims

1. A cleaning device, It is characterized in that include: A housing, wherein the housing forms a housing cavity, and the housing cavity includes a first housing space and a second housing space located above the first housing space; A fluid storage component, movably disposed in the first accommodation space, and the fluid storage component is used to store fluid; A liquid collection component is movably disposed in the second accommodation space, and the liquid collection component includes a reagent needle; as well as A moving component is arranged outside the shell and connected to the liquid taking component. The moving component is used to drive the liquid taking component to move toward or away from the fluid storage component, so that the reagent needle extends into or exits the fluid storage component.

2. The cleaning device according to claim 1, It is characterized in that The liquid collection assembly comprises: a guide rail assembly arranged in the second accommodation space, and a reagent needle fixing plate arranged on the guide rail assembly, and the reagent needle is arranged on the reagent needle fixing plate; Wherein, the moving component is connected to the reagent needle fixing plate, and is used to drive the reagent needle fixing plate to move toward or away from the fluid storage component on the guide rail component, so as to drive the reagent needle to extend into or withdraw from the fluid storage component.

3. The cleaning device according to claim 2, It is characterized in that The guide rail assembly comprises: a guide rail fixing plate, a first guide rail arranged on the guide rail fixing plate, and a sliding block arranged on the first guide rail, and the reagent needle fixing plate is arranged on the sliding block.

4. The cleaning device according to claim 2, It is characterized in that The number of the guide rail components is multiple groups, and the multiple groups of guide rail components are arranged on the periphery of the reagent needle fixing plate.

5. The cleaning device according to claim 2, It is characterized in that The moving assembly includes: a moving component located outside the shell and connected to the reagent needle fixing plate, and a locking mechanism provided on the moving component, wherein the locking mechanism is used to lock or unlock the moving component.

6. The cleaning device according to claim 5, It is characterized in that The locking mechanism comprises: a fixing member arranged on the moving part, an elastic member arranged on the fixing member, a locking shaft arranged at one end of the elastic member, and a buckle arranged on the locking shaft; The shell is respectively provided with a first locking hole and a second locking hole at both ends of the moving path corresponding to the moving part; the elastic member is used to push the locking shaft to pop out and extend into the first locking hole or the second locking hole; the buckle is used to push the locking shaft to withdraw from the first locking hole or the second locking hole under the action of external force, and compress the elastic member.

7. The cleaning device according to claim 6, It is characterized in that The fixing member includes a first wall close to the first locking hole and the second locking hole, a second wall away from the first locking hole and the second locking hole, and a connecting wall connecting the first wall and the second wall; the locking shaft is movably arranged through the first wall and the second wall, and one end of the locking shaft close to the first wall extends out of the movable part; the buckle is arranged on the locking shaft between the first wall and the second wall, and is arranged close to the first wall, and the elastic member is sleeved on the locking shaft and is located between the buckle and the second wall.

8. The cleaning device according to claim 5, It is characterized in that The fluid storage assembly includes: a second guide rail arranged in the first receiving space, a receiving groove arranged on the second guide rail, a container arranged in the receiving groove, and a container fixing plate fixing the container, and the receiving groove can be moved along the second guide rail to move out of or into the first receiving space.

9. The cleaning device according to claim 8, It is characterized in that The container includes at least one of a reagent bottle, a cleaning liquid bottle, a waste liquid bottle and an exhaust bottle.

10. A biochemical substance analysis system, It is characterized in that It comprises a fluid use module and the cleaning device according to any one of claims 1 to 9, wherein the fluid use module is connected to the reagent needle.

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