Special bracket for shooting CBCT (cone beam computed tomography) of experimental animal rat and method thereof

Abstract

The invention discloses a special support for CBCT shooting of an experimental animal rat and a method thereof, and relates to the technical field of experimental animal fixing.The special support comprises a workbench, a center fixing mechanism is arranged above the workbench, the center fixing mechanism comprises a mounting plate arranged above the workbench, and a hydraulic cylinder is fixedly mounted on the side edge of the mounting plate; a transmission rod is arranged at the output end of the hydraulic cylinder, the side, away from the hydraulic cylinder, of the transmission rod is fixedly connected with a double-rack plate, the side edge of the double-rack plate is in meshed connection with a gear, the side, away from the double-rack plate, of the gear is in meshed connection with a single-rack plate, and the side, away from the gear, of the single-rack plate is fixedly connected with a single-rack plate. The side, close to the workbench, of the single-rack plate is fixedly connected with a fixing plate, and the side, away from the transmission rod, of the double-rack plate is fixedly connected with a main protection plate, so that triangular movement center positioning operation of a rat is achieved, it is ensured that the rat can be stably and accurately fixed to the center point position regardless of the body size of the rat, and the rat can be protected. Therefore, the CBCT shooting efficiency and quality are greatly improved.

Description

Technical Field

[0001] The present invention relates to the technical field of experimental animal fixation, and in particular to a special bracket and method for taking CBCT of experimental rats. Background Art

[0002] Rats (Rattus norvegi cus) are animals of the class Mammalia, order Rodentia, family Muridae, and genus Rattus. Generally, adult male rats weigh 300 - 600 g, and female rats weigh 250 - 500 g, with a lifespan of 2.5 - 3 years. The growth and development rate is the same as that of mice, varying with factors such as strain, the physical condition of the mother rat, the number of litters, the number of suckling rats, feed nutrition, and environmental conditions. Generally, rats weighing 180 g - 220 g are used for experiments. In animal experiments, rats are often used as experimental subjects. In order to minimize the impact on the health of animals and relevant observation indicators, reduce the influence of external interference factors on the research target, and prevent animal bites, it is necessary to fix the rats.

[0003] After retrieval, the patent with the Chinese patent number CN220546283U discloses a special bracket for taking CBCT of experimental rats. Aiming at the problems of causing great pain to rats during fixation and the rat's head being prone to compressing the airway, the following solution is proposed, including a rat body bracket and a rat head bracket. The rat body bracket includes a rat body support plate and a movable clamping component. Jacking components are provided on both sides of the rat body support plate, and a rat paw placement groove is provided on the inner plate surface of the rat body support plate. The positioning belt of the movable clamping component is inserted into the jacks at corresponding positions so that rats of different body sizes can be fixedly placed on this bracket; the placement groove is filled with an airbag to fix the rat's paws; the head support plate holds up the rat's head and will not squeeze the rat's trachea, solving the problems that the rat's head is relatively heavy, prone to compressing the airway and causing hypoxia, and the chest rising and falling during breathing leading to artifacts in the image.

[0004] However, in the actual use process of the above device, each time of fixation requires the movable clamping component to be inserted into the corresponding position through the positioning belt. During the clamping process of the rat, it is easy to cause the fixed position of the rat to deviate from the center point, affecting the subsequent CBCT shooting efficiency and reducing the working efficiency of the device. Therefore, it is necessary to propose a special bracket and method for taking CBCT of experimental rats. Summary of the Invention

[0005] The purpose of the present invention is to solve the disadvantages in the prior art that each time of fixation requires the movable clamping component to be inserted into the corresponding position through the positioning belt, which is easy to cause the fixed position of the rat to deviate from the center point during the clamping process of the rat, affecting the subsequent CBCT shooting efficiency and reducing the working efficiency of the device, and to propose a special bracket and method for taking CBCT of experimental rats.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A special bracket for taking CBCT of experimental animal rats, comprising a workbench, a central fixing mechanism is arranged above the workbench, the central fixing mechanism includes a mounting plate arranged above the workbench, a hydraulic cylinder is fixedly installed on the side of the mounting plate, a transmission rod is arranged at the output end of the hydraulic cylinder, a double rack plate is fixedly connected to the side of the transmission rod away from the hydraulic cylinder, a gear is meshed and connected to the side of the double rack plate, a single rack plate is meshed and connected to the side of the gear away from the double rack plate, the single rack plate is fixedly connected to the side away from the gear with a single rack plate, a fixing plate is fixedly connected to the side of the single rack plate close to the workbench, a main protection plate is fixedly connected to the side of the double rack plate away from the transmission rod, after the hydraulic cylinder is started, the double rack plate is driven to move through the transmission rod, the movement of the double rack plate drives the main protection plate to move, the movement of the double rack plate drives the single rack plate to move in an oblique direction through the gear, the single rack plate drives the fixing plate to move obliquely, and two groups of fixing plates are arranged to cooperate with the main protection plate to perform triangular movement central positioning operation on the rats.

[0008] The above technical solution further includes:

[0009] The workbench is fixedly connected with the mounting plate, the gear is rotatably connected with the workbench, a same group of gears are arranged on the side of the double rack plate away from the gear, and the other group of gears meshed and connected to the other side of the double rack plate can drive the other group of fixing plates to move.

[0010] A protective backing plate is fixedly connected to the side of the fixing plate.

[0011] A slide rail is fixedly connected to the outside above the fixing plate, and an airbag clip is slidably connected to the side of the slide rail.

[0012] A chute is opened inside the main protection plate above, and a head support plate is slidably connected inside the chute.

[0013] A special bracket for taking CBCT of experimental animal rats according to the claim, characterized in that a connecting plate is slidably connected below the single rack plate, and the connecting plate is fixedly connected with the workbench.

[0014] A mechanical telescopic frame is fixedly connected to the side of the workbench away from the mounting plate.

[0015] A base is fixedly connected above the mechanical telescopic frame, a spring is fixedly connected to the side of the base close to the mechanical telescopic frame, a support plate is fixedly connected to the side of the spring away from the mechanical telescopic frame, a connecting column is fixedly connected below the support plate, and the connecting column is fixedly connected with the mechanical telescopic frame.

[0016] The side of the support plate is fixedly connected to the side plate. A transmission component is arranged below the side plate, and a CBCT imaging component is arranged on the side of the transmission component away from the side plate.

[0017] Among them, when performing CBCT scanning on animals, it may be necessary to perform it under anesthesia to reduce the stress response and movement of the animals, thereby improving the scanning quality.

[0018] A method for using a special bracket for taking CBCT of experimental animal rats includes the following steps:

[0019] Step 1: A hydraulic cylinder is fixedly installed above the workbench through a mounting plate, so that the hydraulic cylinder can operate stably. Start the central fixing mechanism to make the hydraulic cylinder start to operate;

[0020] Step 2: When the hydraulic cylinder operates, control the transmission rod to move. The movement of the transmission rod makes the double rack plate move. When the double rack plate moves, it drives the main protection plate at the other end to move outside the workbench;

[0021] Step 3: The double rack plate drives the gear to rotate by using the meshing connection relationship. When the gear rotates, it drives the single rack plate to move obliquely. When the single rack plate moves, it drives the fixed plate to move;

[0022] Step 4: The main protection plate and the two fixed plates move towards a central point to perform rapid central fixing operation on the rat.

[0023] The present invention has the following beneficial effects:

[0024] 1. In the present invention, through the coordinated movement of the double rack plate and the single rack plate driven by the hydraulic cylinder, in cooperation with the main protection plate and the two fixed plates, the triangular moving center positioning operation of the rat is realized. This design ensures that no matter the size of the rat, it can be stably and accurately fixed at the central point position, thereby greatly improving the efficiency and quality of CBCT shooting.

[0025] 2. In the present invention, the design of the slide rail and the airbag clip on the fixed plate enables the staff to flexibly adjust the position of the airbag clip according to the specific size and position of the rat to effectively fix the rat's claws. At the same time, the chute and the slidable head support plate on the main protection plate also adapt to rats of different heights and effectively protect and fix their heads, preventing shaking during the shooting process. Description of the Drawings

[0026] Figure 1 It is a schematic structural diagram of a special bracket and its method for taking CBCT of experimental animal rats proposed by the present invention;

[0027] Figure 2 is the external structure schematic diagram in the present invention;

[0028] Figure 3 is the partial three-dimensional structure schematic diagram in the present invention;

[0029] Figure 4 is Figure 1 the enlarged schematic diagram of the structure at position A in;

[0030] Figure 5 is Figure 2 the enlarged schematic diagram of the structure at position B in;

[0031] Figure 6 is Figure 3 the enlarged schematic diagram of the structure at position C in.

[0032] In the figure: 1, workbench; 2, mounting plate; 3, hydraulic cylinder; 4, transmission rod; 5, double rack plate; 6, gear; 7, single rack plate; 8, fixing plate; 9, protective backing plate; 10, main protective plate; 11, slide rail; 12, airbag clip; 13, chute; 14, head support plate; 15, connecting plate; 16, mechanical telescopic frame; 17, base; 18, spring; 19, connecting column; 20, support plate; 21, side plate; 22, transmission assembly; 23, CBCT imaging assembly. Specific embodiments

[0033] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0034] Embodiment 1

[0035] As Figures 1 - 6As shown in the figure, a special bracket for taking CBCT of experimental animal rats includes a workbench 1. Above the workbench 1, a central fixing mechanism is provided. The central fixing mechanism includes a mounting plate 2 arranged above the workbench 1. A hydraulic cylinder 3 is fixedly installed on the side of the mounting plate 2. The output end of the hydraulic cylinder 3 is provided with a transmission rod 4. On the side of the transmission rod 4 away from the hydraulic cylinder 3, a double rack plate 5 is fixedly connected. A gear 6 is meshed and connected to the side of the double rack plate 5. On the side of the gear 6 away from the double rack plate 5, a single rack plate 7 is meshed and connected. On the side of the single rack plate 7 away from the gear 6, a single rack plate 7 is fixedly connected. On the side of the single rack plate 7 close to the workbench 1, a fixing plate 8 is fixedly connected. On the side of the double rack plate 5 away from the transmission rod 4, a main protection plate 10 is fixedly connected. After the hydraulic cylinder 3 is started, the double rack plate 5 is driven to move through the transmission rod 4. The movement of the double rack plate 5 drives the main protection plate 10 to move. The movement of the double rack plate 5 drives the single rack plate 7 to move obliquely through the gear 6. The single rack plate 7 drives the fixing plate 8 to move obliquely. There are two groups of fixing plates 8, which cooperate with the main protection plate 10 to perform triangular moving center positioning operation on the rats.

[0036] The workbench 1 is fixedly connected to the mounting plate 2. The gear 6 is rotatably connected to the workbench 1. On the side of the double rack plate 5 away from the gear 6, there is a same group of gears 6. Another group of gears 6 meshed and connected to the other side of the double rack plate 5 can drive another group of fixing plates 8 to move.

[0037] A protective backing plate 9 is fixedly connected to the side of the fixing plate 8.

[0038] Above the fixing plate 8, an external slide rail 11 is fixedly connected. A pneumatic clamp 12 is slidably connected to the side of the slide rail 11.

[0039] Inside the main protection plate 10, a chute 13 is opened. Inside the chute 13, a head support plate 14 is slidably connected.

[0040] In this embodiment, the central positioning mechanism arranged above the workbench 1 is started, and the rat is placed at the position of the central positioning mechanism. The hydraulic cylinder 3 is fixedly installed above the workbench 1 through the mounting plate 2. The hydraulic cylinder 3 starts to operate and controls the transmission rod 4 arranged at its output end to move, so that the transmission rod 4 can drive the double rack plate 5 fixedly connected to the other end thereof to move. When the double rack plate 5 moves, it drives the main protection plate 10 fixedly connected to the other end thereof to move. A gear 6 is meshed and connected to the side of the double rack plate 5. When the double rack plate 5 moves, it drives the gear 6 to rotate. When the gear 6 rotates, it drives the single rack plate 7 meshed and connected to the other side thereof to move. Since the gear 6 and the single rack plate 7 are in an inclined shape, the single rack plate 7 moves along the inclined plane direction. When the single rack plate 7 moves, it drives the fixing plate 8 fixedly connected to the other side thereof to move. A protective backing plate 9 is fixedly connected to the side of the fixing plate 8 close to the workbench 1, so that the protective backing plate 9 moves in an oblique direction. On the other side of the double rack plate 5, there are the same gear 6, single rack plate 7, fixing plate 8, and protective backing plate 9, so that the other group of fixing plates 8 and protective backing plates 9 move obliquely to one end and form a triangular synchronous movement with the main protection plate 10, thereby fixing the rat above the workbench 1 at the central point position. Regardless of the size of the rat, the fixed position of the rat always remains at the central point, which is beneficial to the subsequent CBCT shooting operation.

[0041] A slide rail 11 is fixedly connected above the fixing plate 8. The staff can move the airbag clip 12 arranged on the side of the slide rail 11, so that the airbag clip 12 slides outside the slide rail 11. When the airbag clip 12 moves to a suitable position, the airbag can be inflated to fix the rat's claws without causing harm to it. A chute 13 is opened inside the upper part of the main protection plate 10. By moving the head support plate 14, it slides inside the chute 13 to adjust the position of the head support plate 14 to adapt to rats of different heights and protect and support its head to prevent the rat's head from shaking randomly during the inspection process.

[0042] Embodiment 2

[0043] As Figures 1 - 6 shown, a connecting plate 15 is slidably connected below the single rack plate 7, and the connecting plate 15 is fixedly connected to the workbench 1.

[0044] A mechanical telescopic frame 16 is fixedly connected to the side of the workbench 1 away from the mounting plate 2.

[0045] A base 17 is fixedly connected above the mechanical telescopic frame 16. A spring 18 is fixedly connected to one side of the base 17 close to the mechanical telescopic frame 16. A support plate 20 is fixedly connected to the side of the spring 18 away from the mechanical telescopic frame 16. A connecting column 19 is fixedly connected below the support plate 20, and the connecting column 19 is fixedly connected to the mechanical telescopic frame 16.

[0046] Side plates 21 are fixedly connected to the sides of the support plate 20. A transmission assembly 22 is arranged below the side plates 21. A CBCT imaging assembly 23 is arranged on the side of the transmission assembly 22 away from the side plates 21.

[0047] In this embodiment, a mechanical telescopic frame 16 is fixedly connected to the other side of the workbench 1. The mechanical telescopic frame 16 can control its own up and down telescoping to adjust the height during CBCT imaging. A base 17 is fixedly connected above the mechanical telescopic frame 16. The other end of the base 17 is fixedly connected to the support plate 20 through a spring 18. Multiple groups of bases 17 and springs 18 are provided. And the support plate 20 and the mechanical telescopic frame 16 are reinforced and connected through a connecting column 19, so that the CBCT can perform a shock absorption operation through multiple groups of springs 18 during imaging to ensure the stability during the imaging process. Side plates 21 are fixedly connected to both sides of the support plate 20. Transmission assemblies 22 for controlling the angular rotation of the CBCT imaging assembly 23 are arranged below the two side plates 21, so that the CBCT imaging assembly 23 can perform CBCT imaging of rats at any height and angle.

[0048] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A special bracket for taking CBCT images of experimental animals and rats, comprising a workbench (1), characterized in that: A central fixing mechanism is arranged above the workbench (1), and the central fixing mechanism comprises a mounting plate (2) arranged above the workbench (1), a hydraulic cylinder (3) is fixedly mounted on the side of the mounting plate (2), a transmission rod (4) is arranged at the output end of the hydraulic cylinder (3), a double rack plate (5) is fixedly connected to the side of the transmission rod (4) away from the hydraulic cylinder (3), a gear (6) is meshedly connected to the side of the double rack plate (5), a single rack plate (7) is meshedly connected to the side of the gear (6) away from the double rack plate (5), a single rack plate (7) is fixedly connected to the side of the single rack plate (7) away from the gear (6), and the single rack plate (7) is fixedly connected to the side of the single rack plate (7) away from the gear (6). 7) A fixed plate (8) is fixedly connected to the side close to the workbench (1), and a main protective plate (10) is fixedly connected to the side of the double rack plate (5) away from the transmission rod (4). After the hydraulic cylinder (3) is started, the double rack plate (5) is driven to move through the transmission rod (4), and the movement of the double rack plate (5) drives the main protective plate (10) to move. The movement of the double rack plate (5) drives the single rack plate (7) to move in an oblique direction through the gear (6), and the single rack plate (7) drives the fixed plate (8) to move obliquely. The fixed plate (8) is provided with two groups and cooperates with the main protective plate (10) to perform a triangular movement center positioning operation on the rat.

2. The special bracket for CBCT imaging of experimental animals and rats according to claim 1, characterized in that: The workbench (1) is fixedly connected to the mounting plate (2), the gear (6) is rotatably connected to the workbench (1), a group of identical gears (6) is provided on the side of the double rack plate (5) away from the gear (6), and another group of gears (6) meshingly connected to the other side of the double rack plate (5) can drive another group of fixed plates (8) to move.

3. The special bracket for CBCT imaging of experimental animals rats according to claim 1, characterized in that: The side edge of the fixing plate (8) is fixedly connected with a protective pad plate (9).

4. The special bracket for CBCT imaging of experimental animals and rats according to claim 1, characterized in that: A slide rail (11) is fixedly connected to the upper exterior of the fixing plate (8), and an airbag clamp (12) is slidably connected to the side of the slide rail (11).

5. The special bracket for CBCT imaging of experimental animals and rats according to claim 1, characterized in that: A slide groove (13) is provided inside the upper part of the main protective plate (10), and a head support plate (14) is slidably connected inside the slide groove (13).

6. The special bracket for CBCT imaging of experimental animals and rats according to claim 1, characterized in that: A connecting plate (15) is slidably connected below the single rack plate (7), and the connecting plate (15) is fixedly connected to the workbench (1).

7. The special bracket for CBCT imaging of experimental animals rats according to claim 1, characterized in that: A mechanical telescopic frame (16) is fixedly connected to a side of the workbench (1) away from the mounting plate (2).

8. The special bracket for CBCT imaging of experimental animals rats according to claim 7, characterized in that: A base (17) is fixedly connected above the mechanical telescopic frame (16); a spring (18) is fixedly connected to a side of the base (17) close to the mechanical telescopic frame (16); a bracket plate (20) is fixedly connected to a side of the spring (18) away from the mechanical telescopic frame (16); a connecting column (19) is fixedly connected below the bracket plate (20); and the connecting column (19) is fixedly connected to the mechanical telescopic frame (16).

9. The special bracket for CBCT imaging of experimental animals rats according to claim 8, characterized in that: The side edge of the support plate (20) is fixedly connected to the side plate (21); a transmission assembly (22) is arranged below the side plate (21); and a CBCT camera assembly (23) is arranged on the side of the transmission assembly (22) away from the side plate (21).

10. The method for using a special bracket for CBCT imaging of experimental animals rats according to claim 1, characterized in that: The following steps are involved: Step 1: The hydraulic cylinder (3) is fixedly mounted on the workbench (1) via the mounting plate (2) so that the hydraulic cylinder (3) can operate stably, and the central fixing mechanism is started so that the hydraulic cylinder (3) starts to operate; Step 2: When the hydraulic cylinder (3) is in operation, the transmission rod (4) is controlled to move, and the operation of the transmission rod (4) causes the double rack plate (5) to move, and when the double rack plate (5) moves, the other end main protection plate (10) is driven to move outside the workbench (1); Step 3: The double rack plate (5) drives the gear (6) to rotate by utilizing the meshing connection relationship, and the rotation of the gear (6) drives the single rack plate (7) to move obliquely at the same time, and the movement of the single rack plate (7) drives the fixed plate (8) to move; Step 4: The main protective plate (10) and the two sets of fixing plates (8) are moved toward a central point to quickly fix the rat in the center.

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