Traditional Chinese medicine ointment for healing sore, promoting tissue regeneration and relieving pain and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine ointment for healing sore, promoting tissue regeneration and relieving pain and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials: 30 to 60g of radix angelicae sinensis, 15 to 30g of radix angelicae dahuricae, 15 to 30g of radix arnebiae seu lithospermi, 15 to 30g of raw liquorice root, 15 to 20g of dragon's blood, 10 to 20g of herba menthae, 200 to 300g of sesame oil and 180 to 300g of The traditional Chinese medicine composition disclosed by the invention is based on compatibility combination of promoting blood circulation to remove blood stasis, cooling blood and detoxifying, removing stasis and diminishing swelling, and astringing sores and promoting tissue regeneration, and is prepared by summarizing clinical experience for many years according to a fixed dosage ratio. The traditional Chinese medicine composition is reasonable in formula, simple to prepare and convenient to use, and the obvious effective rate of the traditional Chinese medicine composition in treatment of pressure sores, herpes zoster, incontinence dermatitis, haemorrhoids and radioactive skin ulcers is up to 90% or above through clinical application verification for many years.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and more specifically, to a traditional Chinese medicine paste for promoting granulation and relieving pain and its preparation method. Background Art

[0002] Chronic wounds, also known as chronic non-healing wounds, non-healing skin ulcers, etc., are one of the common skin diseases in clinical practice, mainly manifested by the protracted non-healing of the wound, including trauma, venous ulcers, pressure sores, diabetic foot ulcers, radiotherapy-related dermatitis, incontinence dermatitis, etc. The wound site is infiltrated by exudate, the wound does not heal for a long time, the risk of wound infection increases, and the inflammation is prone to spread deep into the tissue, eventually leading to deep infection, seriously affecting the life and health of patients.

[0003] Currently, for chronic non-healing wounds, debridement treatment is mostly used to remove necrotic tissue and hematoma on the wound surface to prevent infection, and then external use of povidone iodine and hydrocolloid dressings are used for dressing change treatment, combined with drug treatment. However, the treatment method is complex, the cost is relatively high, and the safety is unclear, and the treatment effect is not very satisfactory.

[0004] Therefore, how to develop a traditional Chinese medicine paste for promoting granulation and relieving pain is an urgent problem to be solved by those skilled in the art. Summary of the Invention

[0005] In view of the above problems, the present invention provides a traditional Chinese medicine paste for promoting granulation and relieving pain and its preparation method.

[0006] The existing debridement treatment and nursing methods have limited anti-inflammatory and bacteriostatic effects and wound healing effects. The chronic and recurrent non-healing skin ulcers not only bring pain to patients, but also aggravate the condition, affect the prognosis, have the risk of secondary skin damage and serious infection, prolong the length of hospital stay, the cost is relatively high, increase the economic burden, and the treatment effect is not very satisfactory. The traditional Chinese medicine paste for promoting granulation and relieving pain of the present invention can well solve the above problems.

[0007] One of the purposes of the present invention is to provide a traditional Chinese medicine paste for promoting granulation and relieving pain, and the raw material composition is as follows: 30-60 g of Angelica sinensis, 15-30 g of Angelica dahurica, 15-30 g of Lithospermum erythrorhizon, 15-30 g of Glycyrrhiza uralensis Fisch., 15-20 g of Dracaena cochinchinensis, 10-20 g of Mentha haplocalyx Briq., 200-300 g of sesame oil, and 180-300 g of vaseline as an adjuvant.

[0008] Preferably, the raw material composition is: 60 g of Angelica sinensis, 20 g of Angelica dahurica, 30 g of Lithospermum erythrorhizon, 20 g of Glycyrrhiza uralensis Fisch., 15 g of Dracaena cochinchinensis, 10 g of Mentha haplocalyx Briq., 300 g of sesame oil, and 300 g of vaseline as an adjuvant.

[0009] The second purpose of the present invention is to provide a preparation method of a traditional Chinese medicine paste for promoting granulation and relieving pain, and the specific steps are as follows:

[0010] (1) Weigh each raw material according to the raw material ratio;

[0011] (2) Put angelica sinensis, dahurian angelica root, lithospermum erythrorhizon, and raw licorice into a pot, pour in sesame oil, cover and soak for a certain period of time;

[0012] (3) Slowly fry over low heat until the sesame oil boils, fry until the medicinal materials are scorched and thoroughly fried, add mint and fry over low heat for 3 minutes, immediately fish out and filter to obtain medicinal oil;

[0013] (4) Break up dragon's blood and put it into the medicinal oil, fry over low heat until it is scorched and withered;

[0014] (5) Filter out the medicinal residues with a fine filter screen and filter repeatedly for multiple times until there is no residue in the medicinal oil;

[0015] (6) Put in vaseline, stir and melt into a paste, mix evenly, finish making the medicine, cool, put it into a sterile container, seal and store for later use.

[0016] Preferably, in step (2), the soaking time is 72 hours.

[0017] Preferably, in step (5), the mesh screen is 200 meshes.

[0018] The third object of the present invention is to provide an application of a traditional Chinese medicine paste for promoting granulation and relieving pain, which is used for treating and nursing various skin pressure sores, incontinence dermatitis, herpes zoster, and hemorrhoids, and has the effects of promoting blood circulation to relieve pain, dissipating stasis and reducing swelling, clearing heat and cooling blood, detoxifying and removing necrosis, and promoting granulation and astringing sores.

[0019] Furthermore, the pharmacological effects of the present invention are as follows:

[0020] Angelica sinensis is warm in nature, pungent and sweet in flavor. It promotes qi and activates blood circulation, relieves pain and promotes granulation growth. It has anti-inflammatory, anti-viral and anti-pathogenic reaction effects, and is good at treating pain caused by blood stasis, serving as the monarch drug; Angelica dahurica is warm in nature and pungent in flavor. It dissipates binds and reduces swelling, promotes blood circulation and drains pus, promotes granulation growth and inhibits bacteria. It can dispel wind on the head and facial skin and relieve the obstruction of muscle dryness and itching; Lithospermum erythrorhizon is bitter and cold. It clears heat and cools blood, purges fire and reduces yang, reduces swelling and relieves pain, dissipates stasis and detoxifies. Together with Angelica dahurica, they serve as the ministerial drugs; Raw licorice purges fire and detoxifies, helps nourish the new. Mentha haplocalyx Briq. is pungent, slightly bitter and slightly cold. It disperses wind-cold, is good at treating scrofula, sores and scabies, wind itching and urticaria, and also treats stings by wasps, scorpions, snakes and cats, serving as the assistant drug. Together with licorice, they serve as the assistant drugs to assist the monarch and ministerial drugs in treating sores; Dragon's blood is sweet and slightly salty. It has the functions of promoting blood circulation to remove blood stasis, anti-inflammatory and analgesic, promoting granulation growth and astringing sores. It can effectively improve the microcirculation of the body, regulate metabolism, improve the microcirculation of the wound, regulate the vascular endothelial growth factor involved in wound healing, promote the shedding of necrotic tissue and the growth of new granulation tissue to help the wound surface heal, serving as the guiding drug. Sesame oil can nourish and lubricate the epidermal skin, has the effects of cooling blood and detoxifying, treating sores and moisturizing, protecting the wound surface, and can also dissolve various drugs to release their active ingredients. When all the drugs are combined, the drug effect directly penetrates into the affected skin, removes the necrotic tissue of the wound surface, promotes repair, stimulates the nerve endings of the local skin, improves the nerve nutrition and blood circulation of the affected area, makes qi and blood smooth, relieves pain, absorbs inflammation, heals the wound surface, has good analgesic, antibacterial, granulation-promoting and sore-astringing effects, makes the scab fall off easily and does not form scars.

[0021] As can be seen from the above technical solutions, compared with the prior art, the beneficial effects of the present invention are as follows:

[0022] (1) The present invention can solve the problems of pain in chronic non-healing wounds, can solve the problem of infection in chronic non-healing wounds, and can solve the problems of safety and efficacy of the external Chinese medicine ointment formula.

[0023] (2) The Chinese medicine combination of the present invention is based on the compatibility combination of promoting blood circulation to remove blood stasis, cooling blood and detoxifying, dissipating binds and reducing swelling, and is a fixed-dose ratio summarized through years of clinical experience.

[0024] (3) The Chinese medicine combination of the present invention can drain pus and promote granulation growth, has antibacterial and antiviral drug effects, and has a good therapeutic effect on chronic non-healing wounds.

[0025] (4) The Chinese medicine combination of the present invention has relatively mild properties and is suitable for use on most chronic non-healing wounds.

[0026] (5) The Chinese medicine combination of the present invention is simple, economical, safe and effective.

[0027] (6) The present invention has good analgesic and granulation-promoting effects on ulcers, pressure sores, herpes zoster, incontinence dermatitis, radiation dermatitis, hemorrhoids, etc. Detailed implementation mode

[0028] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0029] Example 1

[0030] A preparation method of a traditional Chinese medicine paste for promoting granulation, promoting tissue regeneration and relieving pain for treating pressure sores, the specific steps are as follows:

[0031] (1) Weigh Angelica sinensis, Angelica dahurica, Lithospermum erythrorhizon, Glycyrrhiza uralensis Fisch., Dracaena cochinchinensis, Mentha haplocalyx Briq., sesame oil, and the auxiliary material petrolatum;

[0032] (2) Put Angelica sinensis, Angelica dahurica, Lithospermum erythrorhizon, and Glycyrrhiza uralensis Fisch. into a pot, pour in sesame oil, cover and soak for 72 hours;

[0033] (3) Slowly fry over a low heat until the sesame oil boils, fry until the medicinal materials are scorched and fried through, add Mentha haplocalyx Briq. and fry over a low heat for 3 minutes, immediately fish out and filter to obtain medicinal oil;

[0034] (4) Break Dracaena cochinchinensis into pieces, put it into the medicinal oil, and fry over a low heat until it is scorched and withered;

[0035] (5) Filter through a 200-mesh fine filter screen to remove the medicinal residues, filter repeatedly for many times until there are no residues in the medicinal oil;

[0036] (6) Put in petrolatum, stir and melt into a paste, mix evenly, the medicine is ready, cool it, put it into a sterile container, seal and store for later use.

[0037] Since the development of the present invention, a total of 92 patients have been experimented, including 24 cases of pressure sores, 30 cases of incontinence dermatitis, 30 cases of herpes zoster, 5 cases of hemorrhoid pain, and 3 cases of radiation skin ulcers. Basically, all these 92 patients have been effective within 1 to 15 days, with 0 cases of allergy, a healing rate of 80%, a improvement rate of 20%, and an effective rate of 100%.

[0038] Typical cases:

[0039] Case 1: Huang, male, 84 years old, Parkinson's disease, a 10x15 cm stage III pressure sore at the sacrococcygeal region. The patient has been bedridden for a long time, with malnutrition and poor peripheral circulation. Initially, a foam dressing was used to cover the wound, and there was a small amount of purulent secretion on the wound surface, and the wound surface was pale in color, with poor effect. Later, the drug was applied. After changing the dressing two days later, the wound edge converged. After 10 times of dressing changes for 15 days, the large-area wound surface completely healed. This drug not only relieved the patient's pain but also accelerated the healing.

[0040] The formula of the drug raw materials is: 60 g of Angelica sinensis, 30 g of Angelica dahurica, 30 g of Lithospermum erythrorhizon, 36 g of Glycyrrhiza uralensis Fisch., 20 g of Dracaena cochinchinensis, 10 g of Mentha haplocalyx Briq., 250 g of sesame oil, and 300 g of the auxiliary material petrolatum.

[0041] Case 2: Zhang, male, 88 years old, sequelae of stroke, malnutrition. The patient had a stage III pressure ulcer of 15x20 cm at the sacrococcygeal region, with a sinus tract about 7x3 cm deep. The wound surface had a lot of purulent secretions, accompanied by black necrotic tissue. The use of povidone iodine had poor effect. Drug application was given, and dressing was changed once a day. After 3 days, the purulent secretions significantly decreased, the black necrotic tissue fell off, and the sinus tract gradually became shallower. After 15 days of 15 times of dressing change, the pressure ulcer healed.

[0042] The formula of the drug raw materials is as follows: 45 g of Angelica sinensis, 20 g of Angelica dahurica, 25 g of Lithospermum erythrorhizon, 30 g of Glycyrrhiza uralensis, 15 g of Dracaena cochinchinensis, 15 g of Mentha haplocalyx, 200 g of sesame oil, and 250 g of vaseline as auxiliary materials.

[0043] Case 3: Ma, female, 66 years old, after comprehensive treatment of lung cancer. The patient had stage III pressure ulcers of 10x8 cm at the sacrococcygeal region and both buttocks, with malnutrition and poor peripheral circulation. The wound surface did not heal after 2 months of routine dressing change. Then drug application was given, and dressing was changed two days later. The wound edge converged. After 7 times of dressing change in 10 days, the wound surface completely healed.

[0044] The formula of the drug raw materials is as follows: 30 g of Angelica sinensis, 15 g of Angelica dahurica, 15 g of Lithospermum erythrorhizon, 15 g of Glycyrrhiza uralensis, 12 g of Dracaena cochinchinensis, 10 g of Mentha haplocalyx, 230 g of sesame oil, and 180 g of vaseline as auxiliary materials.

[0045] Case 4: Huang, female, 67 years old, herpes zoster of 18x30 cm on the left chest and back. The wound surface had clustered blisters with erythema, and the pain score was 9 points. The pain did not relieve after wet compress with boric acid solution. After using this drug, the pain immediately decreased. Dressing was changed once a day. After 7 days, the blisters absorbed and the erythema subsided.

[0046] The formula of the drug raw materials is as follows: 30 g of Angelica sinensis, 30 g of Angelica dahurica, 30 g of Lithospermum erythrorhizon, 30 g of Glycyrrhiza uralensis, 15 g of Dracaena cochinchinensis, 10 g of Mentha haplocalyx, 200 g of sesame oil, and 200 g of vaseline as auxiliary materials.

[0047] Case 5: Wang, female, 73 years old, Alzheimer's syndrome. Due to long-term bedridden, she had a stage III pressure ulcer of 16x12 cm at the sacrococcygeal region. The wound surface was bright red, with a small amount of bleeding, and the periphery was pale with yellow secretions. After using this drug and changing dressing twice a day, it improved significantly in 3 days, and the wound surface healed after 7 days of medication.

[0048] The formula of the drug raw materials is as follows: 30 g of Angelica sinensis, 15 g of Angelica dahurica, 15 g of Lithospermum erythrorhizon, 15 g of Glycyrrhiza uralensis, 15 g of Dracaena cochinchinensis, 20 g of Mentha haplocalyx, 200 g of sesame oil, and 180 g of vaseline as auxiliary materials.

[0049] The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Chinese medicinal ointment for sore absorptivity, tissue regeneration and pain relief, characterized in that: The raw material composition is as follows: Angelica 30-60g, Angelica dahurica 15-30g, Lithospermum officinale 15-30g, Raw licorice 15-30g, Dragon's blood 15-20g, Mint 10-20g, Sesame oil 200-300g, auxiliary material Vaseline 180-300g.

2. A Chinese medicinal ointment for sore absorptivity, tissue regeneration and pain relief according to claim 1, characterized in that: The raw materials are as follows: 60g of angelica, 20g of angelica dahurica, 30g of lithospermum officinale, 20g of raw licorice, 15g of dragon's blood, 10g of mint, 300g of sesame oil, and 300g of vaseline as an auxiliary material.

3. A method for preparing a Chinese medicinal ointment for sore absorptivity, tissue regeneration and pain relief, characterized in that: The specific steps are as follows: (1) Weigh the raw materials according to the raw material ratio; (2) Place angelica, white angelica root, lithospermum officinale, and raw licorice root into a pot, add sesame oil, and soak for a certain period of time; (3) Slowly fry over low heat until the sesame oil starts to boil, and fry until the herbs turn brown. Add mint and simmer over low heat for 3 min. Remove from the heat and filter immediately to obtain the herbal oil. (4) Crush the dragon's blood, put it into the medicinal oil, and fry it over low heat until it is charred; (5) Use a mesh sieve to filter out the drug residue, and filter repeatedly until there is no residue in the drug oil; (6) Add Vaseline and stir until it dissolves into a paste. Blend evenly, cool, put into a sterile container, and seal for later use.

4. The method for preparing a Chinese medicinal ointment for sore astringency, tissue regeneration and pain relief according to claim 3, characterized in that: In step (2), the soaking time is 72 hours.

5. The method for preparing a Chinese medicinal ointment for sore astringency, tissue regeneration and pain relief according to claim 3, characterized in that: In step (5), the mesh size is 200 meshes.