Externally applied traditional Chinese medicine for treating autologous internal arteriovenous fistula and complications

Abstract

The invention provides a traditional Chinese medicine for external application for treating autologous internal arteriovenous fistula and complications. The traditional Chinese medicine is prepared from the following raw materials: spina gleditsiae, vinegar myrrh, centipede, baked ginger, radix paeoniae rubra, cassia twig, radix puerariae, moutan bark, borneol and gallnut. The function of the autologous internal arteriovenous fistula can be protected, complications are reduced, and the service life of the internal fistula is prolonged.

Description

Technical Field

[0001] The present invention relates to the field of pharmacy, and particularly to a traditional Chinese medicine external application for treating autogenous arteriovenous fistula and its complications. Background Art

[0002] Currently, there are about 850,000 maintenance hemodialysis patients in China, and 77.12% of them use arteriovenous fistulas. Autogenous arteriovenous fistula (AVF) is the preferred access for maintenance hemodialysis patients and is regarded as the "lifeline" of hemodialysis patients. It has the advantages of low stenosis incidence, low thrombosis rate, low infection rate, fewer complications, and long service life. However, clinically, due to factors such as improper puncture, vascular intimal injury, blood pressure drop, limb compression, and prolonged use time, the incidence of its complications is also gradually increasing, affecting the normal function of the fistula. Summary of the Invention

[0003] The purpose of the present invention is to solve the deficiencies in the prior art and propose a traditional Chinese medicine external application for treating autogenous arteriovenous fistula and its complications.

[0004] To achieve the above purpose, the present invention adopts the following technical solution: A traditional Chinese medicine external application for treating autogenous arteriovenous fistula and its complications, comprising the following raw materials: Gleditsia sinensis thorn, Myrrha, Scolopendra, Dry Ginger, Red Peony Root, Cinnamon Twig, Kudzu Root, Moutan Bark, Borneol, Chinese Gallnut.

[0005] Preferably, it comprises the following raw materials: 4 - 8 g of Gleditsia sinensis thorn, 4 - 8 g of Myrrha, 1 - 2 pieces of Scolopendra, 3 - 7 g of Dry Ginger, 4 - 8 g of Red Peony Root, 4 - 8 g of Cinnamon Twig, 4 - 8 g of Kudzu Root, 3 - 7 g of Moutan Bark, 1 - 5 g of Borneol, 3 - 7 g of Chinese Gallnut.

[0006] Preferably, it comprises the following raw materials: 6 g of Gleditsia sinensis thorn, 6 g of Myrrha, 1 piece of Scolopendra, 5 g of Dry Ginger, 6 g of Red Peony Root, 6 g of Cinnamon Twig, 6 g of Kudzu Root, 5 g of Moutan Bark, 3 g of Borneol, 5 g of Chinese Gallnut.

[0007] Preferably, the dispensing agent of the traditional Chinese medicine external application prescription is honey.

[0008] Compared with the prior art, the beneficial effects of the present invention are as follows: By applying traditional Chinese medicine externally, the present invention can reduce swelling and relieve pain, activate blood circulation and dredge collaterals, resist thrombosis and improve microcirculation, playing a role in dredging blood vessels, relieving vasospasm and preventing thrombosis formation. The components of traditional Chinese medicine interact with local skin and tissues, reducing inflammatory reactions, alleviating local swelling, stimulating local blood vessel dilation, improving blood fluidity, making qi and blood unobstructed, interfering with the platelet aggregation process, reducing the risk of thrombosis formation, preventing blood vessel blockage, promoting the maturation of AVF, increasing the blood flow of the internal fistula, reducing the occurrence of complications and improving the dialysis quality of patients. Detailed Embodiments

[0009] To further understand the purpose, structure, characteristics and functions of the present invention, the following is a detailed description in conjunction with embodiments. Embodiment 1

[0010] A traditional Chinese medicine external application for treating autogenous arteriovenous fistula and its complications in an embodiment of the present invention includes the following raw materials: Gleditsia sinensis thorn, Myrrh, Scolopendra, Dry Ginger, Red Peony Root, Cassia Twig, Kudzu Root, Moutan Bark, Borneol, Chinese Gallnut.

[0011] Gleditsia sinensis thorn has the effect of detumescence and detoxicating; Myrrh has the effects of dissipating stasis and relieving pain, promoting tissue regeneration by removing stasis and relieving swelling; Scolopendra has the effects of dredging collaterals to relieve pain, detoxifying and resolving masses; Red Peony Root can cool blood and clear heat, relieve pain and remove stasis; Dry Ginger and Cassia Twig have the effect of warming channels and dredging meridians; Kudzu Root has the effect of promoting the production of body fluid and relaxing meridians; Chinese Gallnut has the effect of astringing dampness and treating sores; Moutan Bark has the effects of clearing heat and cooling blood, promoting blood circulation to remove stasis; Borneol has the effect of clearing heat and relieving pain. The whole formula has the effects of reducing swelling and relieving pain, activating blood circulation and dredging collaterals, resisting thrombosis and improving microcirculation, and preventing scar formation.

[0012] In an embodiment, it includes the following raw materials: 4 - 8 g of Gleditsia sinensis thorn, 4 - 8 g of Myrrh, 1 - 2 Scolopendras, 3 - 7 g of Dry Ginger, 4 - 8 g of Red Peony Root, 4 - 8 g of Cassia Twig, 4 - 8 g of Kudzu Root, 3 - 7 g of Moutan Bark, 1 - 5 g of Borneol, 3 - 7 g of Chinese Gallnut.

[0013] In an embodiment, it includes the following raw materials: 6 g of Gleditsia sinensis thorn, 6 g of Myrrh, 1 Scolopendra, 5 g of Dry Ginger, 6 g of Red Peony Root, 6 g of Cassia Twig, 6 g of Kudzu Root, 5 g of Moutan Bark, 3 g of Borneol, 5 g of Chinese Gallnut.

[0014] In an embodiment, the dispensing agent of the traditional Chinese medicine external application prescription is honey.

[0015] Preparation and usage method: Weigh the raw materials according to the traditional Chinese medicine external application prescription of the present invention, mix and crush them into powder for standby. When using, take an appropriate amount of the powder and mix it with honey and apply it to the affected area. Embodiment 2

[0016] According to Example 1, traditional Chinese medicine external application combined with far-infrared rays is used to treat autogenous arteriovenous fistulas and complications, improve the blood flow of autogenous arteriovenous fistulas, reduce the stenosis rate of fistula blood vessels and the incidence of vascular complications, and improve the function of autogenous arteriovenous fistulas in hemodialysis patients.

[0017] The usage method of traditional Chinese medicine external application combined with far-infrared rays is as follows: (1) Apply hot compress to the affected area with warm water at 40 - 50 °C for 30 minutes; (2) Use honey to mix various medicinal powders and then apply them to the fistula puncture site, avoiding the puncture point, wrap with plastic wrap for 30 minutes, twice a day; (3) Combine far-infrared rays to irradiate the surface of the fistula, the instrument is about 25 cm away from the fistula limb, three times a week, and irradiate for 30 minutes each time.

[0018] Use honey to mix various medicinal powders, apply them externally to the fistula and the surrounding area, combine with far-infrared ray irradiation, the heat promotes the better penetration and absorption of the medicinal power, improves local blood microcirculation, accelerates blood circulation, reduces the formation of thrombus and hematoma, prevents the occurrence of complications such as fistula blood vessel stenosis, occlusion and thrombus, significantly improves the function of arteriovenous fistulas in hemodialysis patients, and improves the dialysis quality of patients.

[0019] Far-infrared heating changes the permeability of plant cells. After the cells are heated, the fluidity of the cell membrane increases, making flavonoid compounds, phenolic acid compounds, resins, glycoside compounds and polyphenol compounds easier to be released from the cells, improving their availability, facilitating penetration through the stratum corneum of the skin, and being beneficial to absorption. The protein component in centipede has a large molecular weight and a complex structure. Infrared heating may cause a certain degree of denaturation of the protein structure in centipede tissue, exposing some amino acids and small peptides wrapped inside the protein, which is beneficial to be absorbed through the gaps of the stratum corneum of the skin and fully play the role of calming endogenous wind and stopping convulsions.

[0020] Clinical experiment:

[0021] 1. Materials and methods:

[0022] 1.1 Research objects: 46 patients who underwent maintenance hemodialysis in our hospital from July 2023 to present were selected and divided into two groups according to the random number table rule. The baseline data of the control group and the research group were input into statistical software for processing, P < 0.05, which was statistically significant. The research was approved by the hospital ethics committee.

[0023] Inclusion criteria: (1) Meeting the criteria of chronic kidney disease (uremic stage) in "Nephrology"; (2) 18 years old ≤ age ≤ 75 years old; (3) Patients who have received maintenance hemodialysis 3 times a week for more than 1 year; (4) The patient has normal mental state and no cognitive and understanding function disorders.

[0024] Exclusion criteria: (1) Allergic to infrared rays or traditional Chinese medicine; (2) With in-situ or metastatic malignant tumors and a predicted survival period of less than half a year; (3) With acute or chronic infectious diseases; (4) With functional diseases of important organs; (5) With skin damage or skin diseases.

[0025] 1.2 Methods: The control group of patients was given regular dialysis treatment. When performing hemodialysis 3 times a week, only far-infrared irradiation treatment was carried out. The study group performed hemodialysis 3 times a week. First, apply warm compress with 40 - 50 °C warm water for 30 minutes. Take an appropriate amount of traditional Chinese medicine powder, mix it with honey and apply it to the arteriovenous fistula puncture site, avoiding the puncture point, wrap it with plastic wrap for 30 minutes, twice a day. At the same time, combine far-infrared irradiation on the surface of the arteriovenous fistula. The instrument is about 25 cm away from the limb with the arteriovenous fistula, 3 times a week, and each irradiation lasts for 30 minutes. Both groups received treatment for half a year for observation and research.

[0026] 1.3 Observation indicators: Before and after treatment, ultrasound was used to detect the blood flow of the arteriovenous fistula in both groups of patients, and the inner diameter and blood flow of the arteriovenous fistula were recorded. The measurement point was 3 - 5 cm proximal to the anastomosis of the arteriovenous fistula. The judgment criteria for the patency of the vascular access: A thrill can be felt by palpation, a vascular murmur can be heard by auscultation, and ultrasound detection indicates that the blood flow of the arteriovenous fistula is 100 - 300 mL / min. At the same time, observe and record the swelling degree of the limb on the side of the autogenous arteriovenous fistula, arteriovenous fistula stenosis, thrombosis, incision infection and other complication occurrences in both groups of patients. At the same time, record the adverse reaction situations that occurred during the treatment process.

[0027] 1.4 Statistical processing: SPSS 26.0 statistical software was used for data analysis. Measurement data were expressed as x±s, and t-test was used. Count data were expressed as rate, and x 2 test was used. P < 0.05 indicated that the difference was statistically significant.

[0028] 2. Results:

[0029] Before treatment, there was no significant difference in the blood flow of the arteriovenous fistula between the two groups (P > 0.05). After treatment, the dialysis blood flow of the arteriovenous fistula in both groups was significantly increased compared with that before treatment, and the difference was statistically significant (P < 0.05); and the study group was significantly higher than the control group after treatment, and the difference was statistically significant (P < 0.05). See Table 1.

[0030]

[0031] Before treatment, there was no significant difference in the inner diameter and wall thickness of the arteriovenous fistula between the two groups (P > 0.05). After treatment, the inner diameter and blood vessel wall of both groups were significantly increased compared with those before treatment, and the difference was statistically significant (P < 0.05). And the study group was significantly higher than the control group after treatment, and the difference was statistically significant (P < 0.05). See Table 2.

[0032]

[0033] The present invention has been described by the above related embodiments. However, the above embodiments are only examples for implementing the present invention. It must be pointed out that the disclosed embodiments do not limit the scope of the present invention. On the contrary, modifications and refinements made without departing from the spirit and scope of the present invention fall within the scope of patent protection of the present invention.

Claims

1. A Chinese medicine for external application for treating autologous arteriovenous fistula and complications, characterized in that: The ingredients include: soapberry thorn, vinegar myrrh, centipede, roasted ginger, red peony root, cassia twig, kudzu root, peony bark, borneol, and gallnut.

2. The Chinese medicine for external application as claimed in claim 1, characterized in that: It includes the following raw materials: 4-8g of soapberry thorn, 4-8g of vinegar myrrh, 1-2 centipedes, 3-7g of roasted ginger, 4-8g of red peony root, 4-8g of cinnamon twig, 4-8g of kudzu root, 3-7g of peony bark, 1-5g of borneol, and 3-7g of gallnut.

3. The Chinese medicine for external application as claimed in claim 2, characterized in that: It includes the following raw materials: 6g of soapberry thorn, 6g of vinegar myrrh, 1 centipede, 5g of roasted ginger, 6g of red peony root, 6g of cinnamon twig, 6g of kudzu root, 5g of peony bark, 3g of borneol, and 5g of gallnut.

4. The Chinese medicine for external application for treating autologous arteriovenous fistula and its complications as described in claims 1-3, characterized in that: The mixing agent of the traditional Chinese medicine external application prescription is honey.

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