Sample analyzer

Abstract

The invention provides a sample analyzer which comprises a shell, a controller, a storage, a reagent needle and an environment temperature sensor, the controller, the storage, the reagent needle and the environment temperature sensor are arranged in the shell, the controller is connected with the storage, the reagent needle and the environment temperature sensor, and the storage is used for storing a heating calibration curve of the heating temperature of the reagent needle. The reagent needle is used for extracting reagent liquid from the reagent container into a cavity in the reagent needle under the control of the controller, heating the reagent liquid in the cavity and discharging the reagent liquid into the reaction container. According to the embodiment of the invention, the controller can determine the heating temperature compensation value based on the first environment temperature sampling value and the heating calibration curve, and correspondingly adjust the heating power or the heating voltage of the reagent needle according to the heating temperature compensation value, so that the temperature of the reagent liquid discharged by the reagent needle is kept within the preset reagent temperature range; the detection accuracy of the sample analyzer is favorably improved.

Description

Technical Field

[0001] This application belongs to the technical field of sample analysis, and particularly relates to a sample analyzer. Background Art

[0002] Currently, a sample analyzer is a device widely used in medical laboratories. When performing some tests using a sample analyzer, such as coagulation tests, it is necessary to ensure that the temperature of the reagent liquid discharged from the reagent needle reaches a specific temperature after the reagent of the sample analyzer is heated for the reagent liquid, in order to ensure the accuracy of the test results. However, during the actual test process of the sample analyzer, due to the influence of environmental factors, the temperature of the reagent liquid discharged from the reagent needle may be lower or higher than the specific temperature, thus affecting the accuracy of the test. Summary of the Invention

[0003] An embodiment of this application provides a sample analyzer. The controller of the sample analyzer can determine a heating temperature compensation value based on the first environmental temperature sampling value and the heating calibration curve, and adjust the heating power or heating voltage of the reagent needle accordingly, so that the temperature of the reagent liquid discharged from the reagent needle remains within a preset reagent temperature range, which is beneficial to improving the accuracy of the detection of the sample analyzer.

[0004] In a first aspect, an embodiment of this application provides a sample analyzer, which includes a housing, and a controller, a memory, a reagent needle, and an environmental temperature sensor disposed in the housing;

[0005] The controller is respectively connected to the memory, the reagent needle, and the environmental temperature sensor;

[0006] The memory is used to store the heating calibration curve of the heating temperature of the reagent needle;

[0007] The reagent needle is used to extract the reagent liquid from the reagent container into its internal chamber under the control of the controller, heat the reagent liquid in the chamber, and then discharge the reagent liquid into the reaction container;

[0008] The environmental temperature sensor is used to collect the environmental temperature around the reagent needle in the housing;

[0009] The controller is configured to obtain a first environmental temperature sampling value, determine the heating temperature compensation value of the reagent needle according to the first environmental temperature sampling value and the heating calibration curve; adjust the heating power or heating voltage of the reagent needle according to the preset heating temperature and the heating temperature compensation value, so that the temperature of the reagent liquid discharged from the reagent needle remains within a preset reagent temperature range;

[0010] Among them, the preset heating temperature is related to the detection items of the sample analyzer.

[0011] In some embodiments, the memory is further configured to store a preheating calibration curve of the reagent needle preheating temperature; the controller is further configured to obtain a second ambient temperature sampling value in the reagent needle cleaning process, determine a preheating temperature compensation value of the reagent needle according to the second ambient temperature sampling value and the preheating calibration curve, and adjust the heating power or heating voltage of the reagent needle according to a preset preheating temperature and the preheating temperature compensation value, so that the preheating temperature of the reagent needle is maintained within a preset preheating temperature range; wherein, the preset preheating temperature is less than the preset heating temperature.

[0012] In some embodiments, the heating calibration curve is used to characterize the continuous linear relationship between the ambient temperature and the heating temperature adjustment coefficient; the controller is configured to determine, according to the first ambient temperature sampling value, the heating temperature adjustment coefficient corresponding to the first ambient temperature sampling value in the heating calibration curve, and then use the heating temperature adjustment coefficient as the heating temperature compensation value.

[0013] In some embodiments, the sample analyzer includes a heating temperature sensor for real-time detection of the heating temperature of the reagent needle;

[0014] The controller is configured to determine a target heating temperature according to a preset heating temperature and the temperature adjustment coefficient, and then adjust the heating power or voltage according to the target heating temperature and the actual heating temperature.

[0015] In some embodiments, the heating calibration curve is used to characterize the continuous linear relationship between the ambient temperature and the temperature adjustment coefficient within a preset ambient temperature range;

[0016] When the controller is configured to determine that the first ambient temperature sampling value does not fall within the preset ambient temperature range, an alarm message is output.

[0017] In some embodiments, the preset heating temperature is 38 °C; or

[0018] The preset reagent temperature range is ±2 °C of the preset heating temperature; or

[0019] At least some of the parameters in the heating calibration curve are determined by synchronous sampling data of a temperature measurement tooling and the ambient temperature sensor, wherein the temperature measurement tooling is used to detect the actual discharge temperature of the reagent liquid in the housing.

[0020] In some embodiments, the controller is configured to obtain a sampled value of the ambient temperature during a single startup cycle of each reagent needle, where a single startup cycle of each reagent needle includes a cleaning step, a reagent liquid aspiration step, a reagent liquid heating step, and a reagent liquid discharge step.

[0021] In some embodiments, the sample analyzer includes a reagent needle swing arm and a reagent needle driving mechanism. The reagent needle driving mechanism is connected to the controller. The reagent needle swing arm supports the reagent needle and is configured to drive the reagent needle to perform horizontal or vertical movement under the drive of the reagent needle driving mechanism; the ambient temperature sensor is disposed on the reagent needle swing arm.

[0022] In some embodiments, the reagent needle includes a liquid extraction needle, a sleeve layer, a heating layer, and a heating temperature sensor; the sleeve layer is sleeved on the outer periphery of the liquid extraction needle, the heating layer is disposed between the liquid extraction needle and the sleeve layer, and the heating temperature sensor is disposed in contact with the heating layer; the heating temperature sensor is configured to collect the real-time heating temperature of the reagent needle.

[0023] In some embodiments, the reagent needle further includes a shielding layer, and the shielding layer is disposed between the liquid extraction needle and the heating layer.

[0024] In the embodiments of the present application, the controller is configured to obtain a first ambient temperature sampled value from the ambient temperature sensor, and obtain a heating calibration curve of the reagent needle heating temperature stored in the memory, and correspondingly adjust the heating power or heating voltage of the reagent needle according to the heating temperature compensation value, so that the temperature of the reagent liquid discharged from the reagent needle is maintained within a preset reagent temperature range, which is beneficial to improving the detection accuracy of the sample analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] To more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for use in the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0026] Figure 1 is a schematic structural diagram of a sample analyzer provided by an embodiment of the present application;

[0027] Figure 2 is a schematic diagram of a heating calibration curve provided by an embodiment of the present application;

[0028] Figure 3 is a schematic physical diagram of a sample analyzer provided by an embodiment of the present application;

[0029] Figure 4It is a schematic structural diagram of a reagent needle provided by an embodiment of the present application;

[0030] Figure 5 It is a schematic physical diagram of a reagent needle provided by an embodiment of the present application;

[0031] Figure 6 It is a schematic physical diagram of another reagent needle provided by an embodiment of the present application;

[0032] Figure 7 It is an enlarged schematic diagram of part A1 provided by an embodiment of the present application;

[0033] Figure 8 It is a flowchart of a temperature control method for a reagent needle provided by an embodiment of the present application;

[0034] Figure 9 It is a schematic physical diagram of another sample analyzer provided by an embodiment of the present application. Detailed implementation manners

[0035] In order to enable those skilled in the art to better understand the solution of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present application.

[0036] The terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally further includes steps or units not listed, or optionally further includes other steps or units inherent to these processes, methods, products or devices.

[0037] Referring to "embodiment" herein means that a specific feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present application. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0038] The "and / or" in the embodiments of the present application describes the association relationship of associated objects and indicates that three relationships may exist. For example, A and / or B may represent the following three situations: A exists alone; A and B exist simultaneously; B exists alone. Among them, A and B may be singular or plural.

[0039] In the embodiments of the present application, the symbol " / " may indicate that the front and rear associated objects have an "or" relationship. In addition, the symbol " / " may also represent a division sign, that is, perform a division operation. For example, A / B may represent A divided by B.

[0040] The "at least one (piece)" or its similar expression in the embodiments of the present application refers to any combination of these items, including any combination of single item (piece) or plural items (pieces), which means one or more, and multiple means two or more. For example, at least one (piece) of a, b, or c may represent the following seven situations: a, b, c, a and b, a and c, b and c, a, b, and c. Among them, each of a, b, and c may be an element or a set containing one or more elements.

[0041] The "equal to" in the embodiments of the present application can be used in combination with "greater than" and is applicable to the technical solutions adopted when it is greater than, and can also be used in combination with "less than" and is applicable to the technical solutions adopted when it is less than. When "equal to" is used in combination with "greater than", it is not used in combination with "less than"; when "equal to" is used in combination with "less than", it is not used in combination with "greater than".

[0042] Please refer to Figure 1 、 Figure 3 、 Figure 4 、 Figure 5 、 Figure 6 and Figure 7 , Figure 1 is a schematic structural diagram of a sample analyzer provided by the embodiments of the present application, Figure 3 is a schematic entity diagram of a sample analyzer provided by the embodiments of the present application, Figure 4 is a schematic structural diagram of a reagent needle provided by the embodiments of the present application, Figure 5 is a schematic entity diagram of a reagent needle provided by the embodiments of the present application, Figure 6 is a schematic entity diagram of another reagent needle provided by the embodiments of the present application, Figure 7 is an enlarged schematic diagram of part A1 provided by the embodiments of the present application. Figure 1 It shows a sample analyzer 1. The sample analyzer 1 includes a housing 10, and a controller 20, a memory 30, a reagent needle 40, and an ambient temperature sensor 50 disposed within the housing 10. The controller 20 is respectively connected to the memory 30, the reagent needle 40, and the ambient temperature sensor 50.

[0043] Among them, the sample analyzer 1 is a device for qualitatively or quantitatively analyzing biological samples to obtain relevant physiological and / or pathological information. Biological samples include, but are not limited to, blood, urine, cerebrospinal fluid, etc.

[0044] Among them, the memory 30 is used to store the heating calibration curve of the heating temperature of the reagent needle 40. The reagent needle 40 is used to extract the reagent liquid from the reagent container into its internal chamber under the control of the controller 20, heat the reagent liquid in the chamber, and then discharge the reagent liquid into the reaction container. The ambient temperature sensor 50 is used to collect the ambient temperature inside the housing around the reagent needle 40.

[0045] Among them, the controller 20 is configured to obtain the first ambient temperature sampling value of the ambient temperature sensor 50, determine the heating temperature compensation value of the reagent needle 40 according to the first ambient temperature sampling value and the heating calibration curve; adjust the heating power or heating voltage of the reagent needle 40 according to the preset heating temperature and the heating temperature compensation value, so that the temperature of the reagent liquid discharged by the reagent needle 40 remains within the preset reagent temperature range.

[0046] Among them, the first ambient temperature sampling value is the ambient temperature sampling value of the ambient temperature sensor 50 during the heating of the reagent liquid by the reagent needle 40.

[0047] Among them, the controller 20 is configured to determine, according to the first ambient temperature sampling value, the heating temperature adjustment coefficient corresponding to the first ambient temperature sampling value in the heating calibration curve, and then use the heating temperature adjustment coefficient as the heating temperature compensation value.

[0048] Please refer to Figure 2 , Figure 2 which is a schematic diagram of a heating calibration curve provided by an embodiment of the present application. The abscissa of the heating calibration curve is the first ambient temperature sampling value, and the ordinate is the heating temperature adjustment coefficient. The first ambient temperature sampling value and the heating temperature adjustment coefficient are negatively correlated. For example, when the first ambient temperature sampling value is 10 °C, the temperature adjustment coefficient corresponding to the first ambient temperature sampling value is 2.1 °C.

[0049] Among them, the preset heating temperature is related to the detection items of the sample analyzer 1. The detection items include, but are not limited to, coagulation test, immunoturbidimetry test, biochemical enzyme detection, specific protein detection, endocrine hormone detection, etc.

[0050] Optionally, the preset heating temperature is 38 °C; or the preset reagent temperature range is ±2 °C of the preset heating temperature; or at least some parameters in the heating calibration curve are determined by the synchronous sampling data of the temperature measurement tooling and the ambient temperature sensor, where the temperature measurement tooling is used to detect the actual discharge temperature of the reagent liquid in the housing.

[0051] Exemplarily, the detection item is a coagulation test, the preset heating temperature can be 38°C, and the preset reagent temperature range can be 36°C - 40°C.

[0052] It can be seen that the controller 20 can control and compensate the heating temperature of the reagent needle 40 in the heating reagent liquid link of the reagent needle 40, so that the temperature of the reagent liquid discharged from the reagent needle 40 remains within the preset reagent temperature range, which is beneficial to improving the detection accuracy of the sample analyzer.

[0053] In some embodiments, the memory 30 is used to store the preheating calibration curve of the preheating temperature of the reagent needle 40; the controller 20 is further configured to obtain the second ambient temperature sampling value in the cleaning link of the reagent needle 40, determine the preheating temperature compensation value of the reagent needle 40 according to the second ambient temperature sampling value and the preheating calibration curve, and adjust the heating power or heating voltage of the reagent needle according to the preset preheating temperature and the preheating temperature compensation value, so that the preheating temperature of the reagent needle 40 remains within the preset preheating temperature range; wherein, the preset preheating temperature is less than the preset heating temperature.

[0054] Wherein, a single start cycle of the reagent needle 40 includes multiple working links, specifically a cleaning link, a reagent liquid suction link, a reagent liquid heating link, and a reagent liquid discharge link. The controller 20 is configured to obtain the sampling value of the ambient temperature in a single start cycle of each reagent needle 40, and preheat the reagent needle 40 in the cleaning link, so that the preheating temperature of the reagent needle 40 remains within the preset preheating temperature range.

[0055] Wherein, the preset preheating temperature can be set manually or default by the system, which is not limited herein. The preset preheating temperature range can be ±2°C of the preset preheating temperature.

[0056] Wherein, the preheating calibration curve is used to characterize the continuous linear relationship between the ambient temperature and the preheating temperature adjustment coefficient; the controller is configured to determine, according to the second ambient temperature sampling value, the preheating temperature adjustment coefficient corresponding to the second ambient temperature sampling value in the preheating calibration curve, and then use the preheating temperature adjustment coefficient as the preheating temperature compensation value.

[0057] Wherein, the abscissa of the preheating calibration curve is the second ambient temperature sampling value, the ordinate is the preheating temperature adjustment coefficient, and the ambient temperature sampling value and the preheating temperature adjustment coefficient are negatively correlated, that is, the smaller the second ambient temperature sampling value, the larger the preheating temperature adjustment coefficient, and the larger the second ambient temperature sampling value, the smaller the preheating temperature adjustment coefficient.

[0058] It can be seen that the controller 20 can control and compensate the preheating temperature of the reagent needle 40 during the preheating process of the reagent needle 40, so that the temperature of the reagent liquid discharged from the reagent needle 40 remains within the preset preheating temperature range, which is beneficial to improving the preheating efficiency and detection accuracy of the sample analyzer.

[0059] In some embodiments, the sample analyzer 1 includes a heating temperature sensor for real-time detection of the heating temperature of the reagent needle 40; the controller 20 is configured to determine a target heating temperature according to a preset heating temperature and the heating temperature adjustment coefficient, and then adjust the heating power or voltage according to the target heating temperature and the actual heating temperature.

[0060] Specifically, the sum of the preset heating temperature and the heating temperature adjustment coefficient can be calculated to obtain the target heating temperature. The controller 20 can adjust the heating power or heating voltage of the reagent needle 40 accordingly according to the change of the target heating temperature compared with the actual heating temperature. For example, if it is analyzed that the target heating temperature is greater than the actual heating temperature, the controller 20 can control to increase the heating power or heating voltage of the reagent needle 40 so that the temperature of the reagent liquid discharged from the reagent needle 40 remains within the preset reagent temperature range; if it is analyzed that the target heating temperature is less than the actual heating temperature, the controller 20 can control to decrease the heating power or heating voltage of the reagent needle 40 so that the temperature of the reagent liquid discharged from the reagent needle 40 remains within the preset reagent temperature range.

[0061] In some embodiments, the controller 20 is configured to determine a target preheating temperature according to a preset heating temperature and the preheating temperature adjustment coefficient, and then adjust the heating power or voltage according to the target preheating temperature and the actual preheating temperature.

[0062] Specifically, the sum of the preset preheating temperature and the preheating temperature adjustment coefficient can be calculated to obtain the target preheating temperature. The controller 20 can adjust the heating power or heating voltage of the reagent needle 40 accordingly according to the change of the target preheating temperature compared with the actual preheating temperature. For example, if it is analyzed that the target preheating temperature is greater than the actual preheating temperature, the controller 20 can control to increase the heating power or heating voltage of the reagent needle 40 so that the preheating temperature of the reagent needle remains within the preset preheating temperature range; if it is analyzed that the target preheating temperature is less than the actual preheating temperature, the controller 20 can control to decrease the heating power or heating voltage of the reagent needle 40 so that the preheating temperature of the reagent needle remains within the preset preheating temperature range.

[0063] In some embodiments, the heating calibration curve is used to characterize the continuous linear relationship between the ambient temperature in a preset ambient temperature range and the heating temperature adjustment coefficient; the controller 20 is configured to output an alarm message when it is determined that the first ambient temperature sampling value does not fall within the preset ambient temperature range.

[0064] Among them, the preset environmental temperature range can be set manually or defaulted by the system, which is not limited here. For example, the preset environmental temperature range is [10°C, 30°C].

[0065] Optionally, the preset environmental temperature range is associated with the type of the sample analyzer. For example, the types of the sample analyzer include the sample analyzer for blood analysis, the sample analyzer for urine analysis, and the sample analyzer for cerebrospinal fluid analysis. The target environmental temperature range corresponding to the sample analyzer for blood analysis is [10°C, 30°C], the target environmental temperature range corresponding to the sample analyzer for urine analysis is [15°C, 30°C], and the target environmental temperature range corresponding to the sample analyzer for cerebrospinal fluid analysis is [18°C, 28°C]; the memory 30 can store preset rules, and the preset rules include the corresponding relationship between the type identifier and the environmental temperature range. The target type identifier of the sample analyzer 1 can be determined, the target environmental temperature range corresponding to the target type identifier in the preset rules can be determined, and the target environmental temperature range is used as the preset environmental temperature range. Among them, the type identifier can be the sample analyzer for blood analysis, the sample analyzer for urine analysis, and the sample analyzer for cerebrospinal fluid analysis.

[0066] Optionally, the sample analyzer 1 includes a display device, the controller 20 is connected to the display device, the controller 20 can output an alarm message to the display device, and the display device displays the alarm message; optionally, the controller 20 of the sample analyzer 1 can be connected to an external monitoring device, the controller 20 can output an alarm message to the monitoring device, and the monitoring device displays the alarm message; optionally, the sample analyzer 1 includes an alarm indicator light, the alarm indicator light is connected to the controller 20, the controller 20 can output an electrical signal carrying the alarm message to the alarm indicator light, and the alarm indicator light lights up; optionally, the sample analyzer 1 includes a buzzer, the controller 20 is connected to the buzzer, and the controller 20 outputs an electrical signal carrying the alarm message to the buzzer, and the buzzer emits an alarm sound.

[0067] In some embodiments, the sample analyzer 1 includes a reagent needle rocker arm 60 and a reagent needle driving mechanism 70. The reagent needle driving mechanism 70 is connected to the controller 20. The reagent needle rocker arm 60 supports the reagent needle 40 and is used to drive the reagent needle 40 to perform horizontal movement or vertical movement under the drive of the reagent needle driving mechanism 70; the environmental temperature sensor 50 is arranged on the reagent needle rocker arm 60.

[0068] Among them, the environmental temperature sensor 50 can also be arranged at other positions suitable for collecting the environmental temperature of the reagent needle 40, which is not limited here.

[0069] In some embodiments, the reagent needle 40 includes a liquid extraction needle 41, a sleeve layer 42, a heating layer 43, and a heating temperature sensor 44; the sleeve layer 42 is sleeved on the outer periphery of the liquid extraction needle 41, the heating layer 43 is disposed between the liquid extraction needle 41 and the sleeve layer 42, and the heating temperature sensor 44 is disposed in contact with the heating layer 43; the heating temperature sensor 44 is used to collect the real-time heating temperature of the reagent needle 40.

[0070] In some embodiments, the reagent needle 40 further includes a shielding layer 45, and the shielding layer 45 is disposed between the liquid extraction needle 41 and the heating layer 43.

[0071] Wherein, the liquid extraction needle 41 has a chamber for sucking and temporarily storing the reagent liquid in the chamber.

[0072] Wherein, the liquid extraction needle 41 is in a hollow tubular structure, and the hollow tube of the liquid extraction needle 41 is the chamber, so that the liquid extraction needle 41 can suck the reagent liquid from the reagent container and temporarily store the sucked reagent liquid in the chamber. The liquid extraction needle 41 can carry the temporarily stored reagent liquid and move to a specified position. For example, after the liquid extraction needle 41 sucks the reagent liquid, the reagent needle 40 moves above the reaction container, and then sprays the reagent liquid into the reaction container, so that the reagent liquid reacts with the sample in the reaction container to achieve the test function.

[0073] Wherein, the heating layer 43 is electrically connected to an external heating circuit and heats the reagent in the reagent accommodating cavity so that the reagent reaches the reference drainage temperature, improving the test accuracy, and the sleeve layer 42 plays a role in supporting and protecting the internal structure of the reagent needle.

[0074] Wherein, the heating layer 43 can be a component with a heating function, such as an electric heating wire or a resistance sheet, which is not limited herein.

[0075] Wherein, the shielding layer 45 can adopt a hollow tubular structure, and the cross-section of the shielding layer 45 can be circular, such as: a perfect circle, an ellipse, which is not limited herein. The shielding layer 45 can also adopt an arc-shaped sheet structure, and at this time, the cross-section of the shielding layer 45 is C-shaped.

[0076] Wherein, the shielding layer 45 is used to achieve the shielding function, and specifically may include at least one of copper skin, aluminum skin, and silver skin, which is not limited herein.

[0077] Wherein, heat insulation and electrical isolation are performed between the liquid extraction needle 41, the shielding layer 45, the heating layer 43, and the sleeve layer 42 by filling an insulating and heat-insulating material, and the insulating and heat-insulating material includes at least one of Teflon, perfluoroalkoxy resin, fluorinated ethylene propylene copolymer, polyvinylidene fluoride, expanded polytetrafluoroethylene, and phenolic resin.

[0078] Wherein, the heating temperature sensor 44 is used to collect the real-time heating temperature of the reagent needle 40 so that the heating temperature of the reagent needle 40 can reach the set heating temperature.

[0079] Among them, by arranging the heating temperature sensor 44 between the sleeve layer 42 and the shielding layer 45, the heating temperature sensor 44 is located on the outer periphery of the shielding layer 45, so that the shielding layer 45 can shield the influence of the heating temperature sensor 44 on the liquid level detection during operation. When detecting the liquid level, it is not necessary to turn off the temperature detection, ensuring that the temperature of the reagent liquid stored in the reagent accommodating cavity is within the set range while ensuring the accuracy of the liquid level detection.

[0080] Among them, the reagent needle 40 further includes a wiring connection pipe assembly 46. The wiring connection pipe assembly 46 is provided with a ventilation hole 461 communicating with the reagent accommodating cavity of the liquid taking needle 41. The ventilation hole 461 is connected to an external air pressure device. The wiring connection pipe assembly 46 is electrically connected to the liquid taking needle and electrically connected to the liquid level detection circuit.

[0081] In some embodiments, the sample analyzer 1 includes a circuit module, and the circuit module is electrically connected to the controller 20; the circuit module includes a heating circuit, a liquid level detection circuit, and a temperature detection circuit, and the reagent needle is respectively connected to the heating circuit, the liquid level detection circuit, and the temperature detection circuit.

[0082] Among them, the liquid taking needle 41 is electrically connected to the liquid level detection circuit for the liquid level detection circuit to detect the liquid level information of the reagent in the reagent accommodating cavity through the liquid taking needle 41. The shielding layer 45 is electrically connected to the ground wire of the liquid level detection circuit, so that the liquid taking needle 41 and the shielding layer 45 are connected in common ground.

[0083] Among them, the sample analyzer 1 includes a fixing member 80. The fixing member 80 is connected to the reagent needle 40 and is used to drive the reagent needle 40 to move within a preset range under the drive of the reagent needle driving mechanism 70.

[0084] Please refer to Figure 8 , Figure 8 is a schematic flow chart of a temperature control method for a reagent needle provided by an embodiment of the present application, which is applied to the controller of a sample analyzer. The sample analyzer includes a housing, and a controller, a memory, a reagent needle, and an ambient temperature sensor provided in the housing. The controller is respectively connected to the memory, the reagent needle, and the ambient temperature sensor. The memory is used to store a heating calibration curve of the heating temperature of the reagent needle. The ambient temperature sensor is used to collect the ambient temperature around the reagent needle in the housing. The method includes:

[0085] Step S801, obtaining a first ambient temperature sampling value from the ambient temperature sensor. Step S802, determining a heating temperature compensation value corresponding to the first ambient temperature sampling value according to the first ambient temperature sampling value and the heating calibration curve.

[0086] Among them, please refer toFigure 2 , Figure 2 The abscissa of the shown heating calibration curve is the first ambient temperature sampling value, and the ordinate is the heating temperature adjustment coefficient. The heating temperature adjustment coefficient corresponding to the first ambient temperature sampling value on the heating calibration curve can be determined, and this heating temperature adjustment coefficient is used as the heating temperature compensation value corresponding to the first ambient temperature sampling value.

[0087] Optionally, the relative difference or relative ratio between the first ambient temperature sampling value and the preset ambient temperature can be determined to obtain a temperature change characterization value. According to the temperature change characterization value and the heating calibration curve, the heating temperature compensation value corresponding to the temperature change characterization value is determined; at this time, the abscissa of the heating calibration curve can be the temperature change characterization value, and the ordinate can be the heating temperature adjustment coefficient. Specifically, the heating temperature compensation coefficient corresponding to the temperature change characterization value on the heating calibration curve can be determined, and this heating temperature adjustment coefficient is used as the heating temperature compensation value corresponding to the first ambient temperature sampling value.

[0088] Among them, the preset ambient temperature can be set manually or by default in the system, which is not limited here. For example: the preset ambient temperature.

[0089] Step S803, determine the target heating temperature according to the heating temperature compensation value and the preset heating temperature, where the preset heating temperature is related to the detection item of the sample analyzer.

[0090] Among them, the target heating temperature = heating temperature compensation value + preset heating temperature.

[0091] Among them, the detection items include but are not limited to coagulation tests, immunoturbidimetric assays, biochemical enzyme assays, specific protein assays, endocrine hormone assays, etc. The foregoing detection items may correspond to the same or different preset heating temperatures.

[0092] Step S804, determine the target heating power or target heating voltage that the reagent needle needs to adjust according to the target heating temperature.

[0093] Specifically, the controller can adjust the heating power or heating voltage of the reagent needle according to the change of the target heating temperature compared with the actual heating temperature, so that the temperature of the reagent liquid discharged from the reagent needle is maintained within the preset reagent temperature range. For example: if it is analyzed that the target heating temperature is greater than the actual heating temperature, the determined target heating power is greater than the current heating power of the reagent needle, or the determined target heating voltage is greater than the current heating voltage of the reagent needle; if it is analyzed that the target heating temperature is less than the actual heating temperature, the determined target heating power is less than the current heating power of the reagent needle, or the determined target heating voltage is less than the current heating voltage of the reagent needle.

[0094] Step S805: Control the reagent needle to adjust the current heating power to the target heating power, or control the reagent needle to adjust the current heating voltage to the target heating voltage.

[0095] Among them, by adjusting the current heating power to the target heating power, or adjusting the current heating voltage to the target heating voltage, the temperature of the reagent liquid discharged from the reagent needle is maintained within a preset reagent temperature range. It can be seen that in this example, the controller can determine the heating temperature compensation value based on the first ambient temperature sampling value and the heating calibration curve, and correspondingly adjust the heating power or heating voltage of the reagent needle according to the heating temperature compensation value, so that the temperature of the reagent liquid discharged from the reagent needle is maintained within a preset reagent temperature range, which is beneficial to improving the detection accuracy of the sample analyzer.

[0096] In some embodiments, the memory is further configured to store a preheating calibration curve of the reagent needle preheating temperature, and the method further includes: obtaining a second ambient temperature sampling value from the ambient temperature sensor, where the second ambient temperature sampling value is the sampling value of the ambient temperature sensor during the reagent needle cleaning process; determining a preheating temperature compensation value corresponding to the second ambient temperature sampling value according to the second ambient temperature sampling value and the preheating calibration curve; determining a target preheating temperature according to the preheating temperature compensation value and the preset heating temperature; determining the target preheating power or target preheating voltage that the reagent needle needs to adjust according to the target preheating temperature; controlling the reagent needle to adjust the current heating power to the target preheating power, or controlling the reagent needle to adjust the current heating voltage to the target preheating voltage.

[0097] Among them, the controller can correspondingly adjust the preheating power or preheating voltage of the reagent needle according to the change of the target preheating temperature compared with the actual preheating temperature, so that the preheating temperature of the reagent needle is maintained within a preset preheating temperature range. For example: if it is analyzed that the target preheating temperature is greater than the actual preheating temperature, the determined target preheating power is greater than the current preheating power of the reagent needle, or the determined target preheating voltage is greater than the current preheating voltage of the reagent needle; if it is analyzed that the target preheating temperature is less than the actual preheating temperature, the determined target preheating power is less than the current preheating power of the reagent needle, or the determined target preheating voltage is less than the current preheating voltage of the reagent needle.

[0098] Among them, the abscissa of the preheating calibration curve is the second ambient temperature sampling value, and the ordinate is the preheating temperature adjustment coefficient. The preheating temperature adjustment coefficient corresponding to the second ambient temperature sampling value in the preheating calibration curve can be determined, and then the preheating temperature adjustment coefficient is used as the preheating temperature compensation value.

[0099] In some embodiments, before determining the heating temperature compensation value corresponding to the first ambient temperature sampling value according to the first ambient temperature sampling value and the heating calibration curve, the above method may include the following steps: determining a preset ambient temperature change range of the sample analyzer; determining a lower ambient temperature value, an upper ambient temperature value, and a periodic change value according to the preset ambient temperature change range; performing a loop operation according to the lower ambient temperature value, the upper ambient temperature value, and the periodic change value to determine multiple ambient temperature sampling values for multiple cycle periods and multiple heating temperature compensation values for multiple cycle periods; creating the heating calibration curve according to the multiple ambient temperature sampling values and the multiple heating temperature compensation values.

[0100] Wherein, the lower ambient temperature value and the upper ambient temperature value are respectively the lower limit value and the upper limit value of the preset ambient temperature change range. For example, if the preset ambient temperature change range is [10°C, 30°C], then the lower ambient temperature value is 10°C and the upper ambient temperature value is 30°C.

[0101] Wherein, multiple sets of ambient temperature sampling values and heating temperature compensation values can be determined by performing a loop operation. There is a corresponding relationship between the ambient temperature sampling values and the heating temperature compensation values in each set. Specifically, the loop operation includes multiple cycle periods. Each cycle period of the loop operation can determine a set of ambient temperature sampling values and heating temperature compensation values. A set of ambient temperature sampling values and heating temperature compensation values includes an ambient temperature sampling value and a heating temperature compensation value. The set of ambient temperature sampling values and heating temperature compensation values can be used as the abscissa value and the ordinate value of a calibration point on the heating calibration curve. In this way, multiple sets of ambient temperature sampling values and heating temperature compensation values can be used as the abscissa values and the ordinate values of multiple calibration points on the heating calibration curve to obtain multiple calibration points. Finally, the heating calibration curve is created according to the multiple calibration points.

[0102] It can be seen that in this example, multiple ambient temperature sampling values and multiple heating temperature compensation values can be determined by performing a loop operation, and the multiple ambient temperature sampling values and the multiple heating temperature compensation values are used as multiple calibration points of the heating calibration curve, and the heating calibration curve is created with the multiple calibration points, which is beneficial to improving the accuracy of creating the heating calibration curve.

[0103] In some embodiments, in the aspect of performing a cyclic operation according to the lower limit value of the ambient temperature, the upper limit value of the ambient temperature, and the cyclic change value, and determining a plurality of ambient temperature sampling values for a plurality of cyclic periods and a plurality of heating temperature compensation values for a plurality of cyclic periods, the above method may include the following steps: determining the ambient temperature of the current cyclic period; determining the ambient temperature sampling value of the ambient temperature sensor at the ambient temperature of the current cyclic period; determining the target heating temperature sampling value of the heating temperature sensor at the ambient temperature of the current cyclic period, where the target heating temperature sampling value is the temperature sampled by the heating temperature sensor when the temperature of the reagent discharged by the reagent needle is the preset liquid discharge temperature; determining a heating temperature difference according to the heating temperature sampling value and the preset heating temperature, and using the heating temperature difference as the heating temperature compensation value for the current cyclic period; repeating the above steps until it is determined that the ambient temperature of the current cyclic period is greater than or equal to the upper limit value of the ambient temperature, and ending the cyclic operation.

[0104] Among them, the ambient temperature of the sample analyzer can be changed, and the ambient temperature sampling value of the ambient temperature sensor and the heating temperature compensation value for each cyclic period can be determined and recorded at the ambient temperature of each cyclic period. Among them, the method of changing the ambient temperature of the sample analyzer is not limited.

[0105] Among them, the heating temperature difference is the difference between the heating temperature sampling value and the preset heating temperature, that is, heating temperature difference = heating temperature sampling value - preset heating temperature.

[0106] For example, the preset ambient temperature change range is [10°C, 30°C], the cyclic change value is 5°C, the cyclic operation includes 5 cyclic periods, and the ambient temperatures of the 5 cyclic periods are 10°C, 15°C, 20°C, 25°C, and 30°C respectively. In the first cyclic period of the cyclic operation, the ambient temperature sampling value at 10°C is determined, and the corresponding heating temperature compensation value is determined. The ambient temperature sampling value and the heating temperature compensation value can be used as the abscissa value and the ordinate value of a calibration point on the heating calibration curve.

[0107] Please refer to Figure 9 , Figure 9 FIG. is a schematic diagram of another sample analyzer provided by an embodiment of the present application. The sample analyzer 1 is electrically connected to the temperature measurement tooling 2. A liquid discharge temperature sensor is arranged inside the temperature measurement tooling 2. The liquid discharge temperature sensor is used to collect the temperature of the reagent discharged by the reagent needle, that is, the liquid discharge temperature sampling value, and transmit the liquid discharge temperature sampling value to the controller. The controller determines the target time point when the liquid discharge temperature sampling value is equal to the preset liquid discharge temperature. The temperature value sampled by the heating temperature sensor at the target time point is the heating temperature sampling value at the ambient temperature of the current cyclic period.

[0108] It can be seen that in this example, by performing a loop operation, multiple environmental temperature sampling values and multiple heating temperature compensation values for multiple cycle periods are determined. The multiple environmental temperature sampling values and multiple heating temperature compensation values serve as multiple calibration points of the heating calibration curve, and a heating calibration curve is created based on the multiple calibration points, which is beneficial to improving the accuracy of creating the heating calibration curve.

[0109] In some embodiments, in terms of determining the environmental temperature of the current cycle period, the above method may include the following steps: If it is determined that the current cycle period is the first cycle period, then use the lower limit value of the environmental temperature as the environmental temperature of the current cycle period; if it is determined that the current cycle period is not the first cycle period, then determine the environmental temperature of the previous cycle period, and based on the environmental temperature of the previous cycle period and the period change value, determine the environmental temperature of the current cycle period.

[0110] Among them, the loop operation uses the lower limit value of the environmental temperature as the environmental temperature of the first cycle period, and the environmental temperature of the last cycle period of the loop operation is greater than or equal to the upper limit value of the environmental temperature.

[0111] Optionally, the addition operation value of the environmental temperature of the previous cycle period and the period change value can be determined, and this addition operation value can be used as the environmental temperature of the current cycle period. For example, assuming the preset environmental temperature change range is [10°C, 30°C], the lower limit value of the environmental temperature is 10°C, the upper limit value of the environmental temperature is 30°C, and the period change value is 5°C, then the environmental temperature of the first cycle period is 10°C. Based on the environmental temperature of the first cycle period, the environmental temperature increases by 5°C for each passed cycle period, and the environmental temperature of the last cycle period of the loop operation is 30°C.

[0112] Optionally, the multiplication operation value of the environmental temperature of the previous cycle period and the period change value can also be determined, and this multiplication operation value can be used as the environmental temperature of the current cycle period. The target environmental temperature change range is [10°C, 30°C], the lower limit value of the environmental temperature is 10°C, the upper limit value of the environmental temperature is 30°C, and the period change value is 1.2. Then the environmental temperature of the first cycle period is 10°C, and the environmental temperature of the previous cycle period × 1.2 = the environmental temperature of the current cycle period.

[0113] It can be seen that in this example, by accurately determining the environmental temperature of each cycle period, it is beneficial to improve the stability of the execution of the loop operation.

[0114] It should be noted that, for the foregoing method embodiments, for the sake of simple description, they are all expressed as a series of action combinations. However, those skilled in the art should know that this application is not limited by the described action sequence, because according to this application, certain steps can be performed in other sequences or simultaneously. Secondly, those skilled in the art should also know that the embodiments described in the specification are all preferred embodiments, and the actions and modules involved are not necessarily essential to this application.

[0115] In the above embodiments, the descriptions of the respective embodiments have their own focuses. For the parts not detailed in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0116] In the several embodiments provided by this application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are only illustrative. For example, the above division of units is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed coupling or direct coupling or communication connection to each other can be through some interfaces. The indirect coupling or communication connection of the device or unit can be in an electrical or other form.

[0117] The units described as separate components above may or may not be physically separated. The components displayed as units may or may not be physical units, that is, they can be located in one place, or they can be distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0118] In addition, in each embodiment of this application, the various functional units can be integrated in a processing unit, or each unit can exist physically alone, or two or more units can be integrated in one unit. The above integrated unit can be implemented in the form of hardware or in the form of a software functional unit.

[0119] If the above integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable memory. Based on this understanding, the technical solution of the present application, in essence, or the part that contributes to the prior art, or all or part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a memory and includes several instructions for causing a computer device (which can be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the above methods in various embodiments of the present application. The aforementioned memory includes various media that can store program codes, such as USB flash drives, read-only memories (ROM, Read-Only Memory), random access memories (RAM, Random Access Memory), mobile hard disks, magnetic disks, or optical discs.

[0120] Those of ordinary skill in the art can understand that all or part of the steps in the various methods of the above embodiments can be completed by instructing relevant hardware through a program. This program can be stored in a computer-readable memory, and the memory can include: flash drives, read-only memories, random access memories, magnetic disks, or optical discs, etc.

Claims

1. A sample analyzer, characterized in that: It includes a housing, and a controller, a memory, a reagent needle and an ambient temperature sensor arranged in the housing; The controller is respectively connected to the memory, the reagent needle and the ambient temperature sensor; The memory is used to store a heating calibration curve of the reagent needle heating temperature; The reagent needle is used to extract the reagent liquid from the reagent container into the chamber inside the reagent container under the control of the controller, and after heating the reagent liquid in the chamber, discharge the reagent liquid into the reaction container; The ambient temperature sensor is used to collect the ambient temperature around the reagent needle in the housing; The controller is configured to obtain a first ambient temperature sampling value of the ambient temperature sensor, determine a heating temperature compensation value of the reagent needle according to the first ambient temperature sampling value and the heating calibration curve; and adjust the heating power or heating voltage of the reagent needle according to a preset heating temperature and the heating temperature compensation value so that the temperature of the reagent liquid discharged from the reagent needle is maintained within a preset reagent temperature range; The preset heating temperature is related to the detection item of the sample analyzer.

2. The sample analyzer according to claim 1, characterized in that: The memory is also used to store a preheating calibration curve of the reagent needle preheating temperature; The controller is further configured to obtain a second ambient temperature sampling value of the reagent needle cleaning link, determine a preheating temperature compensation value of the reagent needle according to the second ambient temperature sampling value and the preheating calibration curve, and adjust the heating power or heating voltage of the reagent needle according to a preset preheating temperature and the preheating temperature compensation value, so that the preheating temperature of the reagent needle is maintained within a preset preheating temperature range; Wherein, the preset preheating temperature is lower than the preset heating temperature.

3. The sample analyzer according to claim 1, characterized in that: The heating calibration curve is used to characterize the continuous linear relationship between the ambient temperature and the heating temperature adjustment coefficient; The controller is configured to determine, according to the first ambient temperature sampling value, a heating temperature adjustment coefficient corresponding to the first ambient temperature sampling value in the heating calibration curve, and then use the heating temperature adjustment coefficient as the heating temperature compensation value.

4. The sample analyzer according to claim 3, characterized in that: The sample analyzer includes a heating temperature sensor for detecting the heating temperature of the reagent needle in real time; The controller is configured to determine a target heating temperature according to a preset heating temperature and the temperature adjustment coefficient, and then adjust the heating power or voltage according to the target heating temperature and an actual heating temperature.

5. The sample analyzer according to claim 1 or 3, characterized in that: The heating calibration curve is used to characterize the continuous linear relationship between the ambient temperature in a preset ambient temperature range and the heating temperature adjustment coefficient; The controller is configured to output an alarm message when it is determined that the first ambient temperature sampling value does not fall within the preset ambient temperature range.

6. The sample analyzer according to claim 1, characterized in that: The preset heating temperature is 38°C; or The preset reagent temperature range is ±2°C of the preset heating temperature; or At least part of the parameters in the heating calibration curve are determined by synchronous sampling data of a temperature measuring tool and the ambient temperature sensor, wherein the temperature measuring tool is used to detect the actual discharge temperature of the reagent solution in the housing.

7. The sample analyzer according to claim 1, characterized in that: The controller is configured to obtain a sample value of the ambient temperature in a single start-up cycle of each reagent needle, wherein the single start-up cycle of each reagent needle includes a cleaning step, a reagent liquid aspirating step, a reagent liquid heating step, and a reagent liquid discharging step.

8. The sample analyzer according to claim 1, characterized in that: The sample analyzer includes a reagent needle rocker arm and a reagent needle driving mechanism, the reagent needle driving mechanism is connected to the controller, the reagent needle rocker arm supports the reagent needle and is used to drive the reagent needle to move horizontally or vertically under the drive of the reagent needle driving mechanism; the ambient temperature sensor is arranged on the reagent needle rocker arm.

9. The sample analyzer according to claim 1 or 8, characterized in that: The reagent needle includes a liquid collection needle, a sleeve layer, a heating layer and a heating temperature sensor; the sleeve layer is sleeved on the outer circumference of the liquid collection needle, the heating layer is arranged between the liquid collection needle and the sleeve layer, and the heating temperature sensor is arranged in contact with the heating layer; the heating temperature sensor is used to collect the real-time heating temperature of the reagent needle.

10. The sample analyzer according to claim 9, characterized in that: The reagent needle further includes a shielding layer, and the shielding layer is arranged between the liquid collection needle and the heating layer.

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