Preparation method of composition with whitening and moisturizing effects

Abstract

The invention relates to a preparation method of a composition with whitening and moisturizing effects, which comprises the following steps: extracting traditional Chinese medicine whitening components, preparing cactus polysaccharide, preparing dendrobium officinale polysaccharide, extracting wula sedge hydrolat, preparing compound wood frog skin whitening and moisturizing cream, preparing whitening and moisturizing nourishing gel, and preparing traditional Chinese medicine whitening and moisturizing cream. A microwave extraction process and a water extraction and alcohol precipitation method are used, traditional Chinese medicine whitening ingredients and moisturizing ingredients are preferably selected, and the composition has the advantage of being high in skin water content after being used.

Description

Technical Field

[0001] The present invention relates to a preparation method of a composition with whitening and moisturizing effects, belonging to the technical field of plant extraction. Background Art

[0002] With the improvement of people's living standards, the pursuit of beauty has become increasingly strong. Whitening and moisturizing are two important aspects of skin care. However, existing whitening and moisturizing products often only meet the needs of one aspect and cannot achieve both whitening and moisturizing effects simultaneously. Therefore, developing a composition with both whitening and moisturizing effects has become an important research topic. Currently, whitening products on the market mainly achieve whitening effects by adding oxidants such as hydrogen peroxide and hydroquinone. However, these oxidants often cause irritation and damage to the skin and even cause allergic reactions. Moisturizing products mainly achieve moisturizing effects by adding natural moisturizing factors such as glycerin and hyaluronic acid, but these products often cannot achieve long-lasting whitening effects. Therefore, developing a composition with both whitening and moisturizing effects has important practical value and market prospects.

[0003] A composition with whitening and moisturizing effects is a composition that combines whitening efficacy and moisturizing function, aiming to optimize healthy and stable traditional Chinese medicine whitening ingredients and moisturizing ingredients using microwave extraction technology and water extraction and alcohol precipitation methods. The present invention has the advantages of delicate product appearance, transparent texture, good stability, excellent whitening, moisturizing, and nourishing properties, and no irritation to the skin. Summary of the Invention

[0004] In view of the above problems, the present invention provides a preparation method of a composition with whitening and moisturizing effects.

[0005] The present invention relates to a preparation method of a composition with whitening and moisturizing effects, and the preparation method includes the following steps: Step (1) extraction of traditional Chinese medicine whitening ingredients, Step (2) preparation of cactus polysaccharide, Step (3) preparation of dendrobium officinale polysaccharide, Step (4) extraction of pure dew of carex meyeriana kunth, Step (5) preparation of compound Rana chensinensis skin whitening and moisturizing ointment, Step (6) preparation of whitening and moisturizing nourishing gel, Step (7) preparation of traditional Chinese medicine whitening and moisturizing cream.

[0006] Preferably, Step (1) extraction of traditional Chinese medicine whitening ingredients Select traditional Chinese medicine powders Atractylodes macrocephala Koidz., Paeonia lactiflora Pall., Glycyrrhiza uralensis Fisch., Pueraria lobata (Willd.) Ohwi, Morus alba L., Polygonatum odoratum (Mill.) Druce, Poria cocos (Schw.) Wolf, Tribulus terrestris L., Dictamnus dasycarpus Turcz., and Polygonatum odoratum (Mill.) Druce, ultrasonically degrease the above traditional Chinese medicine powders with petroleum ether, extract each component with ethanol, allow the extract to stand at room temperature and then carry out microwave reflux, filter and concentrate the filtrate, then evaporate the concentrated filtrate to dryness, and finally obtain the extract of traditional Chinese medicine whitening ingredients; Step (2) preparation of cactus polysaccharide Wash, peel and remove the roots of fresh cactus, cut it into small pieces, put it into a wall-breaking machine to break the wall until it becomes a fine paste; weigh the paste cactus and put it into a round-bottom flask, add petroleum ether to it, put the round-bottom flask on an electric heating mantle, and assemble a reflux device; start timing when reflux occurs, and replace petroleum ether during the period. After the reflux is completed, recover the filtrate, wash the obtained filter residue with petroleum ether, and dry it in a water bath until the excess petroleum ether in the filter residue is dried to obtain a defatted cactus sample; Weigh a defatted cactus sample, add distilled water thereto, soak it in cold water at room temperature while stirring, filter out the supernatant after the extraction is completed to obtain a filter residue and a preliminarily separated supernatant, centrifuge the supernatant to separate the filter residue and the filtrate to obtain a cactus cold extraction extract, and concentrate it using a rotary evaporator to obtain a cold extraction concentrated extract; Weigh a defatted cactus sample, add distilled water thereto, and heat in a water bath for extraction; after the extraction is completed, filter out the supernatant to obtain a filter residue and a preliminarily separated supernatant, centrifuge the supernatant to separate the filter residue and the filtrate, obtain a cactus hot extraction extract, and concentrate it using a rotary evaporator to obtain a hot extraction concentrated extract; First, the pH value of the cold extraction and hot extraction concentrated extracts is adjusted using a NaOH solution and an HCl solution, papain is added thereto, the extracts are stirred evenly, and then placed in a water bath for heating to react, and after the reaction is completed, a trichloroacetic acid solution is added thereto, the extracts are stirred evenly, and then allowed to stand at room temperature for a certain period of time; after the standing is completed, centrifugation is performed, and after the centrifugation is completed, the supernatant is collected, and the obtained supernatant is concentrated using a rotary evaporator, and the pH value of the concentrated solution is adjusted again, and a dialysis bag is taken to remove small molecular substances remaining in the concentrated solution. After the completion of the concentration, the concentrated solution is concentrated and centrifuged again to obtain cactus polysaccharide concentrated solutions extracted by the cold extraction and hot extraction methods, and the concentrated solutions are stored at low temperatures; Add ethanol to the concentrated polysaccharide solution, stir and mix evenly, and let it stand at low temperature for a certain period of time; collect large precipitates after standing, centrifuge the remaining solution, collect the precipitates again, collect the collected precipitates and freeze-dry them in vacuum to obtain cactus cold-extracted polysaccharide component groups and hot-extracted polysaccharide component groups; Step (3) Preparation of Dendrobium officinale polysaccharide The Dendrobium candidum is crushed and sieved, distilled water is added for water bath extraction, the filtrate is centrifuged to obtain the supernatant, the supernatant is concentrated under reduced pressure, ethanol is added to refrigerate the concentrated solution, the concentrated solution is centrifuged twice, the supernatant is discarded after centrifugation, and the precipitate is collected for freeze-drying to obtain the Dendrobium candidum polysaccharide; Step (4) Extraction of Ula grass hydrosol The dried Ula grass is soaked in distilled water to obtain a Ula grass extract, and the extract is distilled to obtain a Ula grass pure dew; Step (5) Preparation of compound Rana sylvatica skin whitening and moisturizing ointment Sterilize the prepared KOH solution by heating in a water bath to obtain an aqueous phase; mix stearic acid, glyceryl monostearate, octadecyl alcohol, and glycerol evenly, and sterilize by heating in a water bath to obtain an oil phase; add the aqueous phase to the oil phase and mix evenly to complete a saponification reaction; after the saponification reaction is completed, add an appropriate amount of preservative parabens and stir evenly, add forest frog skin after cooling, continue stirring until the room temperature becomes a paste, let it stand fully, bottle and seal for storage, and obtain a compound forest frog skin whitening and moisturizing cream; Step (6) Preparation of whitening, moisturizing and nourishing gel Add distilled water to carbomer and glycerin and mix evenly, heat the mixture in a water bath to swell, add lemon extract, lily extract, coix seed extract, blueberry extract, konjac extract, bletilla striata extract, cucumber extract, aloe extract, olive oil, Tween-80, honey after it is completely swollen, stir until the olive oil is evenly dispersed in the water, add triethanolamine, stir and add sorbitol solution, stir again to evenly obtain a matrix, mix ethyl paraben and ethanol evenly, add them to the matrix and stir thoroughly until a crystal clear, delicate and uniform gel is formed to obtain a whitening, moisturizing and nourishing gel; Step (7) Preparation of Chinese herbal whitening and moisturizing cream The traditional Chinese medicine whitening ingredients, cactus polysaccharide, dendrobium officinale polysaccharide, ulala grass hydrosol, compound forest frog skin whitening and moisturizing ointment and whitening and moisturizing nourishing gel are fully mixed to obtain the traditional Chinese medicine whitening and moisturizing cream.

[0007] Preferably, step (1) extracting the whitening ingredients of traditional Chinese medicine 5-20 g each of Chinese medicine powders including Atractylodes macrocephala, white peony root, liquorice, kudzu root, mulberry leaf, polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamni cortex and polygonatum odoratum are selected, and petroleum ether is used to ultrasonically defatted the above Chinese medicine powders, and 5-15 times the amount of 40%-60% ethanol is added to extract the components, and the extract is allowed to stand at room temperature for 5-30 min and then microwave reflux is performed, and the microwave conditions are set to 400-600 W, 100-200 ° C, and 5-10 min. After filtering, the filtrate is concentrated to 1 / 15-1 / 5 of the volume of the original solution, and then the concentrated filtrate is evaporated to dryness to finally obtain an extract of Chinese medicine whitening components.

[0008] The invention has the advantages that the water extract and alcohol extract of Chinese medicines such as white peony root and liquorice have a high inhibition rate on tyrosinase activity; the moisturizing cream made of the whitening ingredients of the Chinese medicines has a delicate appearance, transparent texture, moderate viscosity, good stability, a neutral pH, and has a certain whitening and moisturizing effect.

[0009] Step (2) Preparation of cactus polysaccharide Take fresh cactus, wash it, peel it, remove the roots, and then cut it into small pieces. Put the pieces into a wall breaker and break them until they become a fine paste. Accurately weigh 5 - 20 kg of the paste-like cactus and put it into a round-bottom flask. Add petroleum ether to it according to the solid-liquid ratio of 1:1 - 1:3 g / mL. Place the round-bottom flask on an electric heating mantle and assemble a reflux device. Start timing when reflux appears, time for 1 - 2 hours each time, and repeat 1 - 2 times. During this period, the petroleum ether needs to be replaced. After the reflux ends, recover the filtrate, wash the obtained filter residue with petroleum ether 1 - 3 times, and dry it in a water bath at 50 - 70 °C for 10 - 15 h until the excess petroleum ether in the dried filter residue is removed, obtaining a defatted cactus sample. Weigh 4 - 6 kg of the defatted cactus sample, add distilled water to it according to the solid-liquid ratio of 1:2 - 1:4 g / mL, and soak it in cold water at room temperature for 1 - 3 h. Stir it 1 - 2 times every 10 - 40 min during this period. After the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant. Then, centrifuge the supernatant at 3000 - 5000 r / min for 5 - 20 min to completely separate the filter residue and the filtrate, obtaining the cold extraction solution of cactus. Take 500 - 1500 mL of the cold extraction solution and concentrate it to 1 / 10 - 1 / 2 of the original volume at 60 - 70 °C using a rotary evaporator to obtain the cold-concentrated extraction solution. Weigh 4 - 6 kg of the defatted cactus sample, add distilled water to it according to the solid-liquid ratio of 1:4 - 1:1 g / mL, and extract it by heating in a water bath at 80 - 100 °C for 1 - 3 h. After the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant. Then, centrifuge the supernatant at 3000 - 5000 r / min for 5 - 20 min to completely separate the filter residue and the filtrate, obtaining the hot extraction solution of cactus. Take 500 - 1500 mL of the hot extraction solution and concentrate it to 1 / 10 - 1 / 2 of the original volume at 60 - 70 °C using a rotary evaporator to obtain the hot-concentrated extraction solution. First, use NaOH solution and HCl solution to adjust the pH value of the obtained cold-extracted and hot-extracted concentrated extracts to be controlled at about 5.0 - 7.0. Add papain to it at a liquid-to-material ratio of 100:1 - 20:1 mL / g. After stirring evenly, place it in a water bath and heat it to 40 - 60 °C for reaction. After the reaction ends, add 2.0 - 4.0% trichloroacetic acid solution to it at a volume ratio of 1:1 - 1:2. After stirring evenly, let it stand at room temperature for 20 - 40 min; after standing, centrifuge it at 3000 - 5000 r / min for 5 - 20 min. After centrifugation, collect the supernatant. Concentrate the obtained supernatant to 1 / 2 - 1 / 3 of the original volume with a rotary evaporator, and adjust the pH value of the concentrated solution to about 5.0 - 7.0 again; take a dialysis bag with a molecular weight cut-off of 8000 - 14000 Da to remove the residual small-molecule substances in the concentrated solution. The dialysis time is 20 - 32 h in total, and pure water is changed 1 - 2 times every 4 - 8 h during this period; after completion, concentrate and centrifuge the concentrated solution again to obtain the cactus polysaccharide concentrated solution by cold extraction and hot extraction methods, and store it at 2 - 6 °C; Add 90% - 95% ethanol to the concentrated polysaccharide solution at a volume ratio of 1:1 - 1:6, stir and mix evenly, and let it stand at 2 - 6 °C for 10 - 16 h; after standing, collect the large precipitate, centrifuge the remaining solution at 3000 - 5000 r / min for 5 - 20 min, collect the precipitate part, and recover the solution; after aggregating the collected precipitates, vacuum freeze-dry them to obtain the cold-extracted cactus polysaccharide component group and the hot-extracted cactus polysaccharide component group.

[0010] Adopting the present invention, the advantages are that cactus polysaccharide, as a bioactive component, has multiple bioactivities such as antioxidant, anti-inflammatory, immunomodulatory, and enzyme inhibitory effects.

[0011] Step (3) Preparation of Dendrobium officinale polysaccharide Crush Dendrobium officinale and sieve it. Add distilled water at a material-to-liquid ratio of 1:20 - 1:30 g / mL, and extract it in a water bath at 60 - 100 °C for 1 - 3 times. Centrifuge the filtrate, set the centrifugation conditions as 4000 - 6000 r / min and centrifuge for 5 - 20 min. After centrifugation, take the supernatant, concentrate it under reduced pressure at 40 - 80 °C, add 3 - 5 times the volume of ethanol to refrigerate the concentrated solution at 2 - 6 °C, centrifuge the concentrated solution 1 - 2 times, set the centrifugation conditions as 6000 - 10000 r / min and centrifuge for 5 - 20 min. After centrifugation, discard the supernatant, collect the precipitate and freeze-dry it at -50 ~ -60 °C to obtain Dendrobium officinale polysaccharide.

[0012] Adopting the present invention, the advantages are that Dendrobium officinale polysaccharide has antioxidant properties and has good moisturizing effects.

[0013] Step (4) Extraction of pure dew of Carex meyeriana Kunth After soaking 400 - 600 g of dried Carex meyeriana Kunth in 8000 - 9000 g of purified water for 1 - 3 h, extract it at 80 - 100 °C for 1 - 3 h to obtain the Carex meyeriana Kunth extract, and distill and collect the Carex meyeriana Kunth extract to obtain the pure dew of Carex meyeriana Kunth.

[0014] Adopting the present invention, the advantages are as follows: Carex meyeriana Kunth is a natural traditional Chinese medicine, containing a large amount of plant protein and trace elements required by the human body, having the effects of soothing the nerves and dredging the meridians, and can also improve the microcirculation of the human body and nourish the human skin; Carex meyeriana Kunth contains components that are easily absorbed by the skin, such as amino acids, polysaccharides, and flavonoids with good maintenance effects. The smell of Carex meyeriana Kunth is fragrant and lasting, and after inhalation, it can improve the sleep quality and remove physical fatigue.

[0015] Step (5) Preparation of the compound Rana chensinensis skin whitening and moisturizing ointment Prepare 100 - 200 mL of 0.01 - 0.02 mol / L KOH solution, heat it in a water bath to 80 - 90 °C, keep it for 10 - 30 min for sterilization to obtain the aqueous phase; weigh 10 - 30 g of stearic acid, glycerol monostearate, stearyl alcohol, and glycerol respectively and mix them evenly, heat them in a water bath to 80 - 90 °C, keep it for 10 - 30 min for sterilization to obtain the oil phase; while stirring, add the aqueous phase to the oil phase at 80 - 90 °C in a water bath. After all are added, continue to stir for 40 - 50 min to mix evenly to complete the saponification reaction; after the saponification reaction is completed, add 5 - 10 g of the preservative parabens and stir for 20 - 25 min. After cooling to 40 - 50 °C, add 5 - 15 g of Rana chensinensis skin, continue to stir until it becomes a paste at room temperature, fully stand still, then bottle and seal it for storage to obtain the compound Rana chensinensis skin whitening and moisturizing ointment.

[0016] Adopting the present invention, the advantages are as follows: The surface of Rana chensinensis skin has a perfect moisturizing system, such as hyaluronic acid, collagen, etc. Hyaluronic acid has functions such as moisturizing, sunscreen repair, lubricity, and film-forming; Collagen contains a large number of hydrophilic groups and rich moisturizing factors, has good affinity with surrounding tissues, and has good permeability. It can be filled between the skin matrixes, has a unique role in repairing tissues, can inhibit water loss caused by ultraviolet irradiation, can improve the skin moisture condition, promote the synthesis of hyaluronic acid, and reduce the generation of wrinkles.

[0017] Step (6) Preparation of the whitening, moisturizing and nourishing gel Weigh 0.2 - 0.8 g of carbomer, add 5 - 8 g of glycerol to it, stir evenly, then add 60 - 80 mL of distilled water, heat the mixture in a water bath to 40 - 60 °C until it swells. After complete swelling, add 1 - 2 g of lemon extract, 2 - 4 g of lily extract, 2 - 4 g of coix seed extract, 2 - 4 g of blueberry extract, 2 - 4 g of konjac extract, 2 - 4 g of bletilla striata extract, 2 - 4 g of cucumber extract, 2 - 4 g of aloe extract, 4 - 8 g of olive oil, 0.5 - 1 g of Tween - 80, 2 - 4 g of honey. Stir until the olive oil is evenly dispersed in water, then add 0.05 - 0.1 g of triethanolamine. After stirring, add 60% - 80% of 2 - 3 mL of sorbitol solution and 40 - 45 mL of distilled water, stir evenly again to obtain a matrix. Dissolve 0.3 - 0.5 g of ethyl p - hydroxybenzoate in 5 - 15 mL of 90% - 95% ethanol and mix evenly, add it to the matrix and stir well until a crystal - clear, delicate and uniform gel is formed, thus obtaining the whitening, moisturizing and nourishing gel.

[0018] Adopting the present invention, the advantages are as follows. Aloe is a commonly used raw material in natural plant cosmetics. This patent uses extracts of bletilla striata, lemon, aloe, lily, cucumber, etc. as raw materials to integrate a new dosage form of gel for pharmaceutical preparations and natural plant extracts to develop a new whitening, moisturizing and nourishing gel. Natural plant - based cosmetics have few additives, low toxicity and generally no irritation to the skin.

[0019] Preparation of traditional Chinese medicine whitening and moisturizing cream in step (7) Weigh 5 - 15 g of traditional Chinese medicine whitening components, 5 - 15 g of cactus polysaccharide, 10 - 30 g of dendrobium officinale polysaccharide, 5 - 15 g of pure dew of carex meyeriana, 10 - 30 g of compound Rana temporaria chensinensis skin whitening and moisturizing paste, 5 - 15 g of whitening, moisturizing and nourishing gel respectively, and stir for 20 - 40 min to obtain the traditional Chinese medicine whitening and moisturizing cream.

[0020] Adopting the present invention, the advantages are as follows. The present invention uses traditional Chinese medicine whitening components, cactus polysaccharide, dendrobium officinale polysaccharide, pure dew of carex meyeriana, compound Rana temporaria chensinensis skin whitening and moisturizing paste and whitening, moisturizing and nourishing gel to make a composition, which has both whitening and moisturizing effects. The product has a delicate appearance, transparent texture, good stability, and has good whitening, moisturizing and nourishing properties, and is non - irritating to the skin.

[0021] To sum up, the present invention has the following beneficial effects: 1. Adopting the present invention, the advantages are as follows. The water extracts and alcohol extracts of traditional Chinese medicines such as white peony root and licorice have a high inhibition rate on tyrosinase activity. The moisturizing cream made of this traditional Chinese medicine whitening component has a delicate appearance, transparent texture, moderate viscosity, good stability, a pH tending to neutral, and has a certain whitening and moisturizing effect; 2. The advantages of adopting the present invention are that cactus polysaccharide, as a bioactive ingredient, has multiple bioactivities such as antioxidant, anti-inflammatory, immunomodulatory, and enzyme inhibitory activities; 3. The advantages of adopting the present invention are that dendrobium officinale polysaccharide has antioxidant properties and good moisturizing effects; 4. The advantages of adopting the present invention are that carex meyeriana kunth is a natural traditional Chinese medicine, containing a large amount of plant protein and trace elements required by the human body, having the effects of calming the mind and dredging the meridians, and can also improve human microcirculation and nourish human skin; carex meyeriana kunth contains components that are easily absorbed by the skin, such as amino acids, polysaccharides, and flavonoids with good maintenance effects. The smell of carex meyeriana kunth is fragrant and persistent, and can improve sleep quality and remove physical fatigue after inhalation; 5. The advantages of adopting the present invention are that the surface of the forest frog skin has a perfect moisturizing system, such as hyaluronic acid, collagen, etc. Hyaluronic acid has functions such as moisturizing, sunscreen repair, lubricity, and film-forming; Collagen contains a large number of hydrophilic groups and rich moisturizing factors, has good affinity with surrounding tissues, and has good permeability. It can fill between the skin matrix, has a unique role in repairing tissues, can inhibit water loss caused by ultraviolet irradiation, can improve the skin moisture condition, promote the synthesis of hyaluronic acid, and reduce wrinkle formation; 6. The advantages of adopting the present invention are that aloe vera is a commonly used raw material for natural plant cosmetics. This patent uses extracts of bletilla striata, lemon, aloe vera, lily, cucumber, etc. as raw materials to integrate a new dosage form of gel of pharmaceutical preparations and natural plant extracts to develop a new whitening, moisturizing, and nourishing gel. Natural plant-based cosmetics have few additives, low toxicity, and are generally non-irritating to the skin; 7. The advantages of adopting the present invention are that the present invention uses traditional Chinese medicine whitening ingredients, cactus polysaccharide, dendrobium officinale polysaccharide, pure dew of carex meyeriana kunth, compound forest frog skin whitening and moisturizing paste, and whitening, moisturizing, and nourishing gel to make a composition, which has both whitening and moisturizing effects. The product has a delicate appearance, transparent texture, good stability, and has good whitening, moisturizing, and nourishing properties, and is non-irritating to the skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 is a flowchart of a preparation method of a composition with whitening and moisturizing effects. DETAILED DESCRIPTION OF THE INVENTION

[0023] The following examples are used to illustrate the present invention, but are not used to limit the scope of the present invention. Without departing from the spirit and essence of the present invention, any modification or replacement of the methods, steps, or conditions of the present invention belongs to the scope of the present invention.

[0024] Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art. In addition, all component raw materials used in the examples are known commercially available products.

[0025] Example 1

[0026] Extraction of Traditional Chinese Medicine Whitening Ingredients in Step (1) Select 10 g each of the traditional Chinese medicine powders Atractylodes macrocephala, Paeonia lactiflora, Glycyrrhiza uralensis, Pueraria lobata, Morus alba, Polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamnus dasycarpus, and Polygonatum odoratum. Use petroleum ether to ultrasonically degrease the above traditional Chinese medicine powders, add 10 times the amount of 50% ethanol to extract each component, let the extract stand at room temperature for 10 min and then reflux by microwave. The microwave conditions are set at 400 W, 100 °C, and 7 min. After filtration, concentrate the filtrate to 1 / 10 of the original solution volume, then evaporate the concentrated filtrate to dryness, and finally obtain the extract of traditional Chinese medicine whitening ingredients; Preparation of Opuntia Polysaccharide in Step (2) Take fresh Opuntia, wash, peel, and remove the roots, then cut it into small pieces, put it into a wall breaker and break it until it becomes a delicate paste. Accurately weigh 10.0 kg of the paste-like Opuntia and put it into a 5000 mL round-bottom flask. Add petroleum ether to it according to the solid-liquid ratio of 1:2 g / mL. Place the round-bottom flask on an electric heating mantle, assemble the reflux device, start timing when reflux appears, time for 2 hours each time, repeat 2 times, and replace the petroleum ether during this period; after the reflux ends, recover the filtrate, wash the obtained filter residue with petroleum ether 2 times, heat it in a water bath at 60 °C and dry it for 12 h until the excess petroleum ether in the dried filter residue is removed, and obtain the degreased Opuntia sample; Weigh 5.0 kg of the Opuntia degreased sample, add distilled water to it according to the solid-liquid ratio of 1:3 g / mL, soak it in cold water at room temperature for 2 h, and stir it every 30 min during this period; after the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant, then centrifuge the supernatant at 4000 r / min for 10 min to completely separate the filter residue and the filtrate, and obtain the cold extraction solution of Opuntia. Take 1000 mL of the cold extraction solution and concentrate it to 1 / 5 of the original volume at 65 °C with a rotary evaporator to obtain the cold-concentrated extraction solution; Weigh 5.0 kg of the Opuntia degreased sample, add distilled water to it according to the solid-liquid ratio of 1:4 g / mL, heat and extract it in a water bath at 100 °C for 2 h; after the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant, then centrifuge the supernatant at 4000 r / min for 10 min to completely separate the filter residue and the filtrate, and obtain the hot extraction solution of Opuntia. Take 1000 mL of the hot extraction solution and concentrate it to 1 / 5 of the original volume at 65 °C with a rotary evaporator to obtain the hot-concentrated extraction solution; First, the pH value of the cold extraction and hot extraction concentrated extracts obtained was adjusted to about 6.0 using NaOH solution and HCl solution, papain was added thereto at a liquid-to-solid ratio of 100:3 mL / g, the mixture was stirred evenly, and then heated to 50°C in a water bath for reaction. After the reaction, 3.0% trichloroacetic acid solution was added thereto at a volume ratio of 1:1, the mixture was stirred evenly, and then allowed to stand at room temperature for 30 minutes; after standing, the mixture was centrifuged at 4000 r / min for 10 minutes, and the supernatant was collected after the centrifugation was completed. The supernatant was concentrated to 1 / 2 of the original volume using a rotary evaporator, and the pH value of the concentrate was adjusted to about 6.0 again; an 8000Da dialysis bag was used to remove the small molecular substances remaining in the concentrate, and the dialysis time was a total of 24 hours, during which pure water was replaced every 6 hours; after the end, the concentrate was concentrated and centrifuged again to obtain the cactus polysaccharide concentrates extracted by the cold extraction and hot extraction methods, and stored at 4°C; 95% ethanol was added to the concentrated polysaccharide solution at a volume ratio of 1:4, and the mixture was stirred and evenly mixed. The mixture was allowed to stand at 4°C for 12 h. After standing, large precipitates were collected and the remaining solution was heated at 4000°C. r / min for 10 min, collect the precipitate, and recover the solution; collect the precipitate and freeze-dry it in vacuum to obtain a cactus cold-extracted polysaccharide component group and a heat-extracted polysaccharide component group; Step (3) Preparation of Dendrobium officinale polysaccharide The Dendrobium officinale was crushed and sieved, and distilled water was added at a solid-liquid ratio of 1:25 g / mL, and the mixture was extracted twice in a water bath at 80°C. The filtrate was centrifuged at 5000 r / min for 10 min, and the supernatant was taken after centrifugation. It was concentrated under reduced pressure at 60°C, and 4 times the volume of ethanol was added to refrigerate the concentrate at 4°C. The concentrate was centrifuged twice at 8000 r / min for 10 min, and the supernatant was discarded after centrifugation. The precipitate was collected and freeze-dried at -55°C to obtain Dendrobium officinale polysaccharide. Step (4) Extraction of Ula grass hydrosol 500 g of dried Ula grass was soaked in 8500 g of pure water for 2 hours, and then extracted at 100° C. for 2 hours to obtain a Ula grass extract, and the Ula grass extract was distilled and collected to obtain a Ula grass hydrosol; Step (5) Preparation of compound Rana sylvatica skin whitening and moisturizing ointment Prepare 100mL of 0.01mol / L KOH solution, heat it to 85°C in a water bath, keep it for 20min to sterilize and obtain an aqueous phase; weigh 20g of stearic acid, glyceryl monostearate, octadecyl alcohol and glycerol respectively and mix them evenly, heat it to 85°C in a water bath, keep it for 20min to sterilize and obtain an oil phase; when the water bath is heated to 80-90°C, add the aqueous phase to the oil phase while stirring, continue stirring for 45min after all are added, mix evenly to complete the saponification reaction, after the saponification reaction is completed, add 5g of preservative parabens and stir for 20min, cool it to 45°C, add 5g of Rana sylvatica skin, continue stirring until it becomes a paste at room temperature, let it stand fully, bottle and seal for storage, and obtain a compound Rana sylvatica skin whitening and moisturizing cream; Step (6) Preparation of whitening, moisturizing and nourishing gel Weigh 0.5 g of carbomer, add 6 g of glycerol thereto, stir evenly, add 80 mL of distilled water, heat in a water bath to 50° C. to swell the mixture, add 1 g of lemon extract, 2 g of lily extract, 2 g of coix seed extract, 2 g of blueberry extract, 2 g of konjac extract, 2 g of bletilla striata extract, 2 g of cucumber extract, 2 g of aloe extract, 4 g of olive oil, 0.7 g of Tween-80, and 2 g of honey after complete swelling, stir until the olive oil is evenly dispersed in the water, add 0.0918 g of triethanolamine, stir, add 2.5 mL of 70% sorbitol solution and 42 mL of distilled water, stir again to obtain a matrix, dissolve 0.32 g of ethyl parahydroxybenzoate in 10 mL of 95% ethanol and mix evenly, add to the matrix and stir thoroughly until a crystal clear, delicate and uniform gel is formed to obtain a whitening, moisturizing and nourishing gel; Step (7) Preparation of Chinese herbal whitening and moisturizing cream 10 g of traditional Chinese medicine whitening ingredients, 10 g of cactus polysaccharide, 20 g of Dendrobium officinale polysaccharide, 10 g of Ula grass hydrosol, 20 g of compound Rana silene peel whitening and moisturizing ointment, and 10 g of whitening, moisturizing and nourishing gel were weighed respectively, and stirred for 30 minutes to obtain a traditional Chinese medicine whitening and moisturizing cream.

[0027] Example 2 Step (1) Extraction of whitening ingredients from traditional Chinese medicine 5 g each of Chinese medicine powders of Atractylodes macrocephala, Paeonia lactiflora, Licorice, Pueraria root, Morus alba, Polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamni cortex and Polygonatum odoratum were selected, and the above Chinese medicine powders were ultrasonically defatted using petroleum ether, and 5 times the amount of 50% ethanol was added to extract the components, and the extract was allowed to stand at room temperature for 5 min and then microwave refluxed, and the microwave conditions were set to 400 W, 100 ° C, 5 min, and the filtrate was concentrated to 1 / 15 of the volume of the original solution after filtration, and then the concentrated filtrate was evaporated to dryness, and finally the extract of the whitening component of Chinese medicine was obtained; Step (2) Preparation of cactus polysaccharide Take fresh cactus, wash it, peel it, remove the roots, and then cut it into small pieces. Put the pieces into a wall breaker and break it until it becomes a delicate paste. Accurately weigh 5 kg of the paste-like cactus and put it into a round-bottom flask. Add petroleum ether to it according to the solid-liquid ratio of 1:1 g / mL. Place the round-bottom flask on an electric heating mantle and assemble a reflux device. Start timing when reflux appears, time for 2 hours each time, and repeat 2 times. During this period, the petroleum ether needs to be replaced. After the reflux ends, recover the filtrate, wash the obtained filter residue with petroleum ether once, and heat it in a water bath at 50 °C for 10 h until the excess petroleum ether in the dried filter residue is removed, obtaining a defatted cactus sample; Weigh 4 kg of the defatted cactus sample, add distilled water to it according to the solid-liquid ratio of 1:4 g / mL, and soak it in cold water at room temperature for 1 h, stirring it every 10 min during this period. After the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant. Then, centrifuge the supernatant at 3000 r / min for 5 min to completely separate the filter residue and the filtrate, obtaining the cold extraction solution of cactus. Take 500 mL of the cold extraction solution and concentrate it to 1 / 10 of its original volume at 65 °C using a rotary evaporator to obtain the cold extraction concentrated solution; Weigh 4 kg of the defatted cactus sample, add distilled water to it according to the solid-liquid ratio of 1:4 g / mL, and heat it in a water bath at 80 °C for 1 h for extraction. After the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant. Then, centrifuge the supernatant at 3000 r / min for 5 min to completely separate the filter residue and the filtrate, obtaining the hot extraction solution of cactus. Take 500 mL of the hot extraction solution and concentrate it to 1 / 10 of its original volume at 65 °C using a rotary evaporator to obtain the hot extraction concentrated solution; First, use NaOH solution and HCl solution to adjust the pH value of the obtained cold extraction and hot extraction concentrated solutions to be controlled at about 5.0. Add papain to it according to the liquid-solid ratio of 100:1 mL / g, stir evenly, and then put it into a water bath and heat it to 40 °C for reaction. After the reaction ends, add 3.0% trichloroacetic acid solution to it in a volume ratio of 1:1, stir evenly, and then let it stand at room temperature for 20 min. After standing, centrifuge it at 3000 r / min for 5 min. After centrifugation, collect the supernatant, concentrate the obtained supernatant to 1 / 2 of its original volume using a rotary evaporator, and adjust the pH value of the concentrated solution to about 5.0 again. Take a dialysis bag with a molecular weight cut-off of 8000 Da to remove the residual small molecule substances in the concentrated solution. The dialysis time is a total of 20 h, and the pure water is replaced every 4 h during this period. After the end, concentrate and centrifuge the concentrated solution again to obtain the cactus polysaccharide concentrated solutions obtained by the two extraction methods of cold extraction and hot extraction, and store them at 2 °C; Add 95% ethanol to the concentrated polysaccharide solution in a volume ratio of 1:1, stir and mix evenly, and let it stand at 2°C for 10 h. After standing, collect the large precipitates, centrifuge the remaining solution at 3000 r / min for 5 min, collect the precipitate part, and recover the solution. After aggregating the collected precipitates, perform vacuum freeze-drying to obtain the cold-extracted polysaccharide component group and the hot-extracted polysaccharide component group of cactus. Step (3) Preparation of Dendrobium officinale polysaccharide Crush Dendrobium officinale and sieve it. Add distilled water at a solid-liquid ratio of 1:20 g / mL, extract it once in a water bath at 60°C, centrifuge the filtrate, set the centrifugation conditions as 4000 r / min and centrifuge for 5 min. After centrifugation, take the supernatant, concentrate it under reduced pressure at 40°C, add 3 volumes of ethanol to the concentrated solution and refrigerate it at 2°C. Centrifuge the concentrated solution for the second time, set the centrifugation conditions as 6000 r / min and centrifuge for 5 min. After centrifugation, discard the supernatant, collect the precipitate and freeze-dry it at -50°C to obtain Dendrobium officinale polysaccharide. Step (4) Extraction of pure dew of Carex meyeriana Kunth Take 400 g of dried Carex meyeriana Kunth, soak it in 8000 g of pure water for 1 h, and extract it at 80°C for 1 h to obtain the extraction solution of Carex meyeriana Kunth. Distill and collect the extraction solution of Carex meyeriana Kunth to obtain the pure dew of Carex meyeriana Kunth. Step (5) Preparation of compound Rana temporaria chensinensis David skin whitening and moisturizing ointment Prepare 100 mL of 0.01 mol / L KOH solution, heat it in a water bath to 80°C, and keep it for 10 min for sterilization to obtain the aqueous phase. Weigh 10 g of stearic acid, glycerol monostearate, octadecanol, and glycerol respectively and mix them evenly, heat them in a water bath to 80°C, and keep it for 10 min for sterilization to obtain the oil phase. When heating in a water bath to 80°C, add the aqueous phase to the oil phase while stirring. After adding all of it, continue to stir for 40 min to mix evenly and complete the saponification reaction. After the saponification reaction is completed, add 5 g of preservative parabens and stir for 20 min. Cool it to 40°C and then add 5 g of Rana temporaria chensinensis David skin, continue to stir until it becomes paste at room temperature, let it stand fully and then bottle and seal it for storage to obtain the compound Rana temporaria chensinensis David skin whitening and moisturizing ointment. Step (6) Preparation of whitening, moisturizing and nourishing gel Weigh 0.2 g of carbomer, add 5 g of glycerol to it, stir evenly, then add 60 mL of distilled water, heat the mixture in a water bath to 40 °C until it swells. After complete swelling, add 1 g of lemon extract, 2 g of lily extract, 2 g of coix seed extract, 2 g of blueberry extract, 2 g of konjac extract, 2 g of bletilla striata extract, 2 g of cucumber extract, 2 - 4 g of aloe vera extract, 4 g of olive oil, 0.5 g of Tween - 80, and 2 g of honey. Stir until the olive oil is evenly dispersed in water, then add 0.05 g of triethanolamine. After stirring, add 2 mL of 70% sorbitol solution and 40 mL of distilled water, and stir evenly again to obtain a matrix. Dissolve 0.3 g of ethyl p - hydroxybenzoate in 5 mL of 95% ethanol and mix evenly, then add it to the matrix and stir well until a crystal - clear, delicate and uniform gel is formed, obtaining a whitening, moisturizing and nourishing gel; Preparation of Traditional Chinese Medicine Whitening and Moisturizing Cream in Step (7) Weigh 5 g of traditional Chinese medicine whitening components, 5 g of cactus polysaccharide, 10 g of dendrobium officinale polysaccharide, 5 g of pure dew of carex meyeriana, 10 g of compound Rana temporaria skin whitening and moisturizing ointment, and 5 g of whitening, moisturizing and nourishing gel respectively. After stirring for 20 min, obtain the traditional Chinese medicine whitening and moisturizing cream.

[0028] Example 3 Extraction of Traditional Chinese Medicine Whitening Components in Step (1) Select 10 g each of traditional Chinese medicine powders Atractylodes macrocephala, Paeonia lactiflora, Glycyrrhiza uralensis, Pueraria lobata, Morus alba leaf, Polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamnus dasycarpus Turcz. and Polygonatum odoratum. Use petroleum ether to ultrasonically degrease the above traditional Chinese medicine powders, add 10 - fold amount of 50% ethanol to extract each component. Let the extract stand at room temperature for 10 min and then carry out microwave reflux. The microwave conditions are set as 500 W, 150 °C, and 10 min. After filtration, concentrate the filtrate to 1 / 10 of the original solution volume, then evaporate the concentrated filtrate to dryness, and finally obtain the extract of traditional Chinese medicine whitening components; Preparation of Cactus Polysaccharide in Step (2) Take fresh cactus, wash it, peel it, remove the roots, and then cut it into small pieces. Put it into a blender and break it until it becomes a delicate paste; accurately weigh 15 kg of the pasty cactus and put it into a round - bottom flask. Add petroleum ether to it according to the solid - liquid ratio of 1:2 g / mL. Place the round - bottom flask on an electric heating mantle and assemble a reflux device; start timing when reflux appears, time for 2 hours each time, repeat 2 times, and change the petroleum ether during this period; after the reflux ends, recover the filtrate, wash the obtained filter residue with petroleum ether 2 times, heat it in a water bath at 60 °C and dry it for 12 h until the excess petroleum ether in the dried filter residue is removed, obtaining a degreased cactus sample; Weigh 5 kg of defatted cactus sample, add distilled water according to the solid-liquid ratio of 1:3 g / mL, soak in cold water at room temperature for 2 h, and stir once every 20 min; filter out the supernatant after the extraction to obtain a filter residue and a preliminarily separated supernatant, then centrifuge the supernatant at 4000 r / min for 10 min to completely separate the filter residue and the filtrate to obtain a cactus cold extraction extract, take 1000 mL of the cold extraction extract and concentrate it to 1 / 5 of the original volume using a rotary evaporator at 65 ° C to obtain a cold extraction concentrated extract; Weigh 5 kg of defatted cactus sample, add distilled water according to the solid-liquid ratio of 1:3 g / mL, and heat in a water bath at 90°C for 2 h; after the extraction, filter out the supernatant to obtain a filter residue and a preliminarily separated supernatant, then centrifuge the supernatant at 4000 r / min for 10 min to completely separate the filter residue and the filtrate to obtain a cactus hot extraction extract, take 1000 mL of the hot extraction extract and concentrate it to 1 / 5 of the original volume using a rotary evaporator at 65°C to obtain a hot extraction concentrated extract; First, the pH value of the cold extraction and hot extraction concentrated extracts obtained was adjusted to about 6.0 using NaOH solution and HCl solution, papain was added thereto at a liquid-to-solid ratio of 50:1 mL / g, the mixture was stirred evenly, and then heated to 50°C in a water bath for reaction. After the reaction, 3.0% trichloroacetic acid solution was added thereto at a volume ratio of 1:2, and the mixture was stirred evenly and allowed to stand at room temperature for 30 minutes. After standing, the mixture was centrifuged at 4000 r / min for 10 minutes, and the supernatant was collected after centrifugation. The supernatant was concentrated to 1 / 2 of the original volume using a rotary evaporator, and the pH value of the concentrate was adjusted to about 6.0 again. A 10000Da dialysis bag was used to remove the small molecular substances remaining in the concentrate, and the dialysis time was 24 hours in total, during which pure water was replaced every 6 hours. After the end, the concentrate was concentrated and centrifuged again to obtain the cactus polysaccharide concentrates extracted by the cold extraction and hot extraction methods, and stored at 4°C. Add 95% ethanol to the concentrated polysaccharide solution at a volume ratio of 1:3, stir and mix evenly, and let stand at 4°C for 12 hours; collect large precipitates after standing, centrifuge the remaining solution at 4000r / min for 10 minutes, collect the precipitate, and recover the solution; collect the collected precipitates and freeze-dry them in a vacuum to obtain a cactus cold-extracted polysaccharide component group and a heat-extracted polysaccharide component group; Step (3) Preparation of Dendrobium officinale polysaccharide The Dendrobium officinale was crushed and sieved, and distilled water was added at a solid-liquid ratio of 1:25 g / mL, and the mixture was extracted twice in a water bath at 80°C. The filtrate was centrifuged at 5000 r / min for 10 min, and the supernatant was taken after centrifugation. It was concentrated under reduced pressure at 60°C, and 4 times the volume of ethanol was added to refrigerate the concentrate at 4°C. The concentrate was centrifuged twice at 8000 r / min for 15 min. The supernatant was discarded after centrifugation, and the precipitate was collected and freeze-dried at -55°C to obtain Dendrobium officinale polysaccharide. Step (4) Extraction of Ula grass hydrosol 500 g of dried Ula grass was soaked in 8500 g of pure water for 2 hours, and then extracted at 90° C. for 2 hours to obtain a Ula grass extract, and the Ula grass extract was distilled and collected to obtain a Ula grass hydrosol; Step (5) Preparation of compound Rana sylvatica skin whitening and moisturizing ointment Prepare 200mL of 0.01mol / L KOH solution, heat it to 85°C in a water bath, keep it for 20min to sterilize and obtain an aqueous phase; weigh 20g of stearic acid, glyceryl monostearate, octadecyl alcohol, and glycerol respectively and mix them evenly, heat it to 85°C in a water bath, keep it for 20min to sterilize and obtain an oil phase; when the water bath is heated to 85°C, add the aqueous phase to the oil phase while stirring, continue stirring for 45min after all are added, and mix evenly to complete the saponification reaction; after the saponification reaction is completed, add 8g of preservative parabens and stir for 24min, cool to 45°C, add 10g of Rana sylvatica skin, continue stirring until it becomes a paste at room temperature, let it stand fully, bottle and seal for storage, and obtain a compound Rana sylvatica skin whitening and moisturizing ointment; Step (6) Preparation of whitening, moisturizing and nourishing gel Weigh 0.6g of carbomer, add 6g of glycerol thereto, stir evenly, add 70mL of distilled water, heat in a water bath to 50°C to swell the mixture, add 1.5g of lemon extract, 3g of lily extract, 3g of coix seed extract, 3g of blueberry extract, 3g of konjac extract, 3g of bletilla striata extract, 3g of cucumber extract, 3g of aloe extract, 6g of olive oil, 0.8g of Tween-80, and 3g of honey after complete swelling, stir until the olive oil is evenly dispersed in the water, add 0.08g of triethanolamine, stir, add 2.5mL of 70% sorbitol solution and 42mL of distilled water, stir again to obtain a matrix, dissolve 0.4g of ethyl parahydroxybenzoate in 10mL of 95% ethanol and mix evenly, add to the matrix and stir thoroughly until a crystal clear, delicate and uniform gel is formed to obtain a whitening, moisturizing and nourishing gel; Step (7) Preparation of Chinese herbal whitening and moisturizing cream Weigh 10 g of traditional Chinese medicine whitening ingredients, 10 g of cactus polysaccharide, 15 g of dendrobium officinale polysaccharide, 10 g of pure dew of carex meyeriana kunth, 20 g of compound Rana chensinensis skin whitening and moisturizing ointment, and 10 g of whitening, moisturizing and nourishing gel respectively. After stirring for 30 min, a traditional Chinese medicine whitening and moisturizing cream is obtained.

[0029] Example 4

[0030] Step (1) Extraction of traditional Chinese medicine whitening ingredients Select 20 g of each of the traditional Chinese medicine powders Atractylodes macrocephala Koidz., Paeonia lactiflora Pall., Glycyrrhiza uralensis Fisch., Pueraria lobata (Willd.) Ohwi, Morus alba L., Polygonatum odoratum (Mill.) Druce, Poria cocos (Schw.) Wolf, Tribulus terrestris L., Dictamnus dasycarpus Turcz., and Polygonatum odoratum (Mill.) Druce. Use petroleum ether to ultrasonically degrease the above traditional Chinese medicine powders, add 15 times the amount of 50% ethanol to extract each component, let the extract stand at room temperature for 30 min and then carry out microwave reflux. The microwave conditions are set as 600 W, 200 °C, and 10 min. After filtration, concentrate the filtrate to 1 / 5 of the original solution volume, and then evaporate the concentrated filtrate to dryness. Finally, an extract of traditional Chinese medicine whitening ingredients is obtained; Step (2) Preparation of cactus polysaccharide Take fresh cactus, wash it, peel it, remove the roots, and then cut it into small pieces. Put it into a wall breaker and break it until it becomes a delicate paste; accurately weigh 20 kg of the paste-like cactus and put it into a round-bottom flask. Add petroleum ether to it according to the solid-liquid ratio of 1:3 g / mL. Place the round-bottom flask on an electric heating mantle and assemble a reflux device; start timing when reflux appears, time for 2 hours each time, and repeat 2 times. During this period, petroleum ether needs to be replaced; after the reflux ends, recover the filtrate, wash the obtained filter residue with petroleum ether 3 times, and heat it in a water bath at 70 °C for 15 h until the excess petroleum ether in the dried filter residue is removed, obtaining a degreased cactus sample; Weigh 6 kg of the degreased cactus sample, add distilled water to it according to the solid-liquid ratio of 1:4 g / mL, soak it in cold water at room temperature for 3 h, and stir it once every 40 min during this period; after the extraction ends, filter out the supernatant, obtaining a filter residue and a preliminarily separated supernatant. Then, centrifuge the supernatant at 5000 r / min for 20 min to completely separate the filter residue and the filtrate, obtaining a cold extraction solution of cactus. Take 1500 mL of the cold extraction solution and concentrate it to 1 / 2 of the original volume at 65 °C using a rotary evaporator, obtaining a cold-concentrated extraction solution; Weigh 6 kg of the degreased cactus sample, add distilled water to it according to the solid-liquid ratio of 1:4 g / mL, and heat it in a water bath at 100 °C for 3 h for extraction; after the extraction ends, filter out the supernatant, obtaining a filter residue and a preliminarily separated supernatant. Then, centrifuge the supernatant at 5000 r / min for 20 min to completely separate the filter residue and the filtrate, obtaining a hot extraction solution of cactus. Take 1500 mL of the hot extraction solution and concentrate it to 1 / 2 of the original volume at 65 °C using a rotary evaporator, obtaining a hot-concentrated extraction solution; First, the pH value of the cold extraction and hot extraction concentrated extracts obtained was adjusted to about 7.0 using NaOH solution and HCl solution, papain was added thereto at a liquid-to-solid ratio of 20:1 mL / g, the mixture was stirred evenly, and then heated to 60°C in a water bath for reaction. After the reaction, 3.0% trichloroacetic acid solution was added thereto at a volume ratio of 1:2, and the mixture was stirred evenly and allowed to stand at room temperature for 40 minutes. After standing, the mixture was centrifuged at 5000 r / min for 20 minutes, and the supernatant was collected after centrifugation. The supernatant was concentrated to 1 / 3 of the original volume using a rotary evaporator, and the pH value of the concentrate was adjusted to about 7.0 again. A 14000Da dialysis bag was used to remove the small molecular substances remaining in the concentrate, and the dialysis time was 32 hours in total, during which pure water was replaced every 8 hours. After the end, the concentrate was concentrated and centrifuged again to obtain the cactus polysaccharide concentrates extracted by the cold extraction and hot extraction methods, and stored at 6°C. Add 95% ethanol to the concentrated polysaccharide solution at a volume ratio of 1:6, stir and mix evenly, and let stand at 6°C for 16 hours; collect large precipitates after standing, centrifuge the remaining solution at 5000r / min for 20 minutes, collect the precipitate, and recover the solution; collect the collected precipitates and freeze-dry them in vacuum to obtain a cactus cold-extracted polysaccharide component group and a heat-extracted polysaccharide component group; Step (3) Preparation of Dendrobium officinale polysaccharide The Dendrobium candidum was crushed and sieved, and distilled water was added at a solid-liquid ratio of 1:30 g / mL. The mixture was extracted in a water bath at 100°C for 3 times. The filtrate was centrifuged at 6000 r / min for 20 min. The supernatant was taken after centrifugation, and concentrated under reduced pressure at 80°C. Five times the volume of ethanol was added to refrigerate the concentrate at 6°C. The concentrate was centrifuged twice at 10000 r / min for 20 min. The supernatant was discarded after centrifugation, and the precipitate was collected and freeze-dried at -60°C to obtain Dendrobium candidum polysaccharide. Step (4) Extraction of Ula grass hydrosol 600 g of dried Ula grass and 9000 g of pure water were soaked for 3 hours, and then extracted at 100° C. for 3 hours to obtain Ula grass extract, and the Ula grass extract was distilled and collected to obtain Ula grass pure dew; Step (5) Preparation of compound Rana sylvatica skin whitening and moisturizing ointment Prepare 200mL of 0.02mol / L KOH solution, heat it to 90°C in a water bath, keep it for 30min to sterilize and obtain an aqueous phase; weigh 30g of stearic acid, glyceryl monostearate, octadecyl alcohol, and glycerol respectively and mix them evenly, heat it to 90°C in a water bath, keep it for 30min to sterilize and obtain an oil phase; when the water bath is heated to 90°C, add the aqueous phase to the oil phase while stirring, continue stirring for 50min after all are added, and mix evenly to complete the saponification reaction; after the saponification reaction is completed, add 10g of preservative parabens and stir for 25min, cool it to 50°C, add 15g of Rana sylvatica skin, continue stirring until it becomes a paste at room temperature, let it stand fully, bottle it and seal it for storage, and obtain a compound Rana sylvatica skin whitening and moisturizing ointment; Step (6) Preparation of whitening, moisturizing and nourishing gel Weigh 0.8g of carbomer, add 5-8g of glycerol thereto, stir evenly, add 80mL of distilled water, heat in a water bath to 60°C and swell the mixture, add 2g of lemon extract, 4g of lily extract, 4g of coix seed extract, 4g of blueberry extract, 4g of konjac extract, 4g of bletilla striata extract, 4g of cucumber extract, 4g of aloe extract, 8g of olive oil, 1g of Tween-80, and 4g of honey after complete swelling, stir until the olive oil is evenly dispersed in the water, add 0.1g of triethanolamine, stir, add 70% 3mL of sorbitol solution and 45mL of distilled water, stir again to obtain a matrix, dissolve 0.5g of ethyl parahydroxybenzoate in 15mL of 95% ethanol and mix evenly, add to the matrix and stir thoroughly until a crystal clear, delicate and uniform gel is formed to obtain a whitening, moisturizing and nourishing gel; Step (7) Preparation of Chinese herbal whitening and moisturizing cream 15 g of traditional Chinese medicine whitening ingredients, 15 g of cactus polysaccharide, 30 g of Dendrobium officinale polysaccharide, 15 g of Ula grass hydrosol, 30 g of compound Rana silene peel whitening and moisturizing ointment, and 15 g of whitening, moisturizing and nourishing gel were weighed respectively, and stirred for 40 minutes to obtain a traditional Chinese medicine whitening and moisturizing cream.

[0031] Comparative Example 1

[0032] Step (1) Extraction of whitening ingredients from traditional Chinese medicine 5 g each of Chinese medicine powders including Atractylodes macrocephala, Paeonia lactiflora, Licorice, Pueraria root, Morus alba, Polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamni cortex and Polygonatum odoratum were selected, and the above Chinese medicine powders were ultrasonically defatted using petroleum ether, and 5 times the amount of 50% ethanol was added to extract the components, and the extract was allowed to stand at room temperature for 15 min and then microwave refluxed, and the microwave conditions were set to 450 W, 150 ° C, and 8 min. After filtering, the filtrate was concentrated to 1 / 12 of the volume of the original solution, and then the concentrated filtrate was evaporated to dryness, and finally the extract of the whitening component of the Chinese medicine was obtained; Step (2) Preparation of cactus polysaccharide Wash, peel and remove the roots of fresh cactus, cut it into small pieces, put it into a wall breaking machine to break the wall until it becomes a fine paste; accurately weigh 12 kg of cactus paste and put it into a round-bottom flask, add petroleum ether according to the solid-liquid ratio of 1:2 g / mL, put the round-bottom flask on an electric heating mantle, and assemble a reflux device; start timing when reflux occurs, and count for 2 hours each time, repeat 2 times, and replace petroleum ether during the period; after the reflux is completed, recover the filtrate, wash the obtained filter residue once with petroleum ether, heat the water bath to 55°C and dry it for 12 hours until the excess petroleum ether in the filter residue is dried to obtain a defatted cactus sample; Weigh 5 kg of defatted cactus sample, add distilled water according to the solid-liquid ratio of 1:3 g / mL, soak in cold water at room temperature for 2 h, and stir every 30 min; filter out the supernatant after extraction to obtain filter residue and preliminarily separated supernatant, then centrifuge the supernatant at 3500 r / min for 15 min to completely separate the filter residue and filtrate to obtain cactus cold extraction extract, take 800 mL of cold extraction extract and concentrate it to 1 / 6 of the original volume using a rotary evaporator at 65 ° C to obtain a cold extraction concentrated extract; Weigh 4 kg of defatted cactus sample, add distilled water according to the solid-liquid ratio of 1:3 g / mL, and heat in a water bath at 80°C for 2 h; after the extraction, filter out the supernatant to obtain a filter residue and a preliminarily separated supernatant, then centrifuge the supernatant at 4000 r / min for 15 min to completely separate the filter residue and the filtrate to obtain a cactus hot extraction extract, take 800 mL of the hot extraction extract and concentrate it to 1 / 6 of the original volume using a rotary evaporator at 65°C to obtain a hot extraction concentrated extract; First, the pH value of the cold extraction and hot extraction concentrated extracts obtained was adjusted to about 5.0 using NaOH solution and HCl solution, papain was added thereto at a liquid-to-solid ratio of 80:1 mL / g, the mixture was stirred evenly, and then heated to 40°C in a water bath for reaction, and after the reaction was completed, 3.0% trichloroacetic acid solution was added thereto at a volume ratio of 1:1, and the mixture was stirred evenly and allowed to stand at room temperature for 30 minutes; after the standing was completed, the mixture was centrifuged at 4500 r / min for 15 minutes, and the supernatant was collected after the centrifugation was completed, and the obtained supernatant was concentrated to 1 / 3 of the original volume using a rotary evaporator, and the pH value of the concentrated solution was adjusted to about 6.0 again; after the completion, the concentrated solution was concentrated and centrifuged again to obtain cactus polysaccharide concentrated solutions extracted by cold extraction and hot extraction, and stored at 4°C; Add 95% ethanol to the concentrated polysaccharide solution at a volume ratio of 1:4, stir and mix evenly, and let stand at 3°C ​​for 12 hours; collect large precipitates after standing, centrifuge the remaining solution at 4000r / min for 15 minutes, collect the precipitate, and recover the solution; collect the collected precipitates and freeze-dry them in vacuum to obtain a cactus cold-extracted polysaccharide component group and a heat-extracted polysaccharide component group; Step (3) Preparation of Dendrobium officinale polysaccharide The Dendrobium officinale was crushed and sieved, and distilled water was added at a solid-liquid ratio of 1:20 g / mL. It was extracted once in a water bath at 90 °C. The filtrate was centrifuged, and the centrifugation conditions were set at 4000 r / min for 15 min. After centrifugation, the supernatant was taken, and the precipitate was collected and freeze-dried at -55 °C to obtain Dendrobium officinale polysaccharide; Step (4) Preparation of compound Rana temporaria chensinensis skin whitening and moisturizing ointment Prepare 200 mL of 0.01 mol / L KOH solution, heat it in a water bath to 85 °C, and keep it for 30 min for sterilization to obtain the aqueous phase; Weigh 30 g of stearic acid, glycerol monostearate, stearyl alcohol, and glycerol respectively and mix them evenly. Heat them in a water bath to 85 °C and keep it for 10 min for sterilization to obtain the oil phase; When heating in a water bath to 80 °C, add the aqueous phase to the oil phase while stirring. After all is added, continue to stir for 40 min to mix evenly to complete the saponification reaction; After cooling to 50 °C, add 15 g of Rana temporaria chensinensis skin, continue to stir until room temperature to form a paste, fully stand still and then bottle and seal it to obtain the compound Rana temporaria chensinensis skin whitening and moisturizing ointment; Step (5) Preparation of whitening, moisturizing and nourishing gel Weigh 0.2 g of carbomer, add 5 g of glycerol to it, stir evenly, then add 70 mL of distilled water, heat it in a water bath to 40 °C to swell the mixture. After complete swelling, add 2 g of lemon extract, 4 g of lily extract, 4 g of coix seed extract, 4 g of blueberry extract, 4 g of konjac extract, 4 g of bletilla striata extract, 4 g of cucumber extract, 4 g of aloe vera extract, 8 g of olive oil, 1 g of Tween-80, and 4 g of honey. Stir until the olive oil is evenly dispersed in water, then add 0.1 g of triethanolamine, stir, and then add 3 mL of 70% sorbitol solution and 45 mL of distilled water, stir evenly again to obtain the matrix. Dissolve 0.5 g of ethyl p-hydroxybenzoate in 15 mL of 95% ethanol and mix evenly, add it to the matrix and stir well until a crystal-clear, delicate and uniform gel is formed to obtain the whitening, moisturizing and nourishing gel; Step (6) Preparation of traditional Chinese medicine whitening and moisturizing cream Weigh 15 g of traditional Chinese medicine whitening ingredient, 15 g of Opuntia dillenii polysaccharide, 30 g of Dendrobium officinale polysaccharide, 15 g of pure dew of Carex meyeriana Kunth, 30 g of compound Rana temporaria chensinensis skin whitening and moisturizing ointment, and 15 g of whitening, moisturizing and nourishing gel respectively, stir for 30 min to obtain the traditional Chinese medicine whitening and moisturizing cream.

[0033] Comparative Example 2

[0034] Step (1) Extraction of traditional Chinese medicine whitening ingredient Select 20 g each of the traditional Chinese medicine powders Atractylodes macrocephala, Paeonia lactiflora, Glycyrrhiza glabra, Pueraria lobata, Morus alba leaf, Polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamnus dasycarpus, and Polygonatum odoratum. Use petroleum ether to ultrasonically degrease the above traditional Chinese medicine powders, add 15 times the amount of 50% ethanol to extract each component, let the extract stand at room temperature for 5 min and then reflux by microwave. Set the microwave conditions to 600 W, 200 °C, and 10 min. After filtration, concentrate the filtrate to 1 / 5 of the original solution volume, then evaporate the concentrated filtrate to dryness, and finally obtain the extract of the traditional Chinese medicine whitening components; Step (2) Preparation of cactus polysaccharide Take fresh cactus, wash it, peel it, remove the roots, and then cut it into small pieces. Put it into a wall breaker and break it until it becomes a delicate paste; accurately weigh 20 kg of the paste-like cactus and put it into a round-bottom flask. Add petroleum ether to it according to the solid-liquid ratio of 1:3 g / mL. Place the round-bottom flask on an electric heating mantle and assemble a reflux device; start timing when reflux appears, time for 2 hours each time, repeat 2 times, and replace petroleum ether during this period; after the reflux ends, recover the filtrate, wash the obtained filter residue with petroleum ether 3 times, and heat it in a water bath at 70 °C for 15 h until the excess petroleum ether in the dried filter residue is removed to obtain the degreased cactus sample; Weigh 4 kg of the degreased cactus sample, add distilled water to it according to the solid-liquid ratio of 1:4 g / mL, soak it in cold water at room temperature for 3 h, and stir it every 40 min during this period; after the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant. Then centrifuge the supernatant at 3000 r / min for 20 min to completely separate the filter residue and the filtrate to obtain the cold-extracted cactus extract. Take 1000 mL of the cold-extracted extract and concentrate it to 1 / 10 of the original volume at 65 °C using a rotary evaporator to obtain the cold-concentrated extract; Weigh 6 kg of the degreased cactus sample, add distilled water to it according to the solid-liquid ratio of 1:3 g / mL, and heat it in a water bath at 100 °C for 3 h for extraction; after the extraction ends, filter out the supernatant to obtain the filter residue and the preliminarily separated supernatant. Then centrifuge the supernatant at 5000 r / min for 20 min to completely separate the filter residue and the filtrate to obtain the hot-extracted cactus extract. Take 1000 mL of the hot-extracted extract and concentrate it to 1 / 10 of the original volume at 65 °C using a rotary evaporator to obtain the hot-concentrated extract; First, the pH value of the cold extraction and hot extraction concentrated extracts obtained was adjusted to about 7.0 using NaOH solution and HCl solution, and papain was added thereto at a liquid-to-solid ratio of 80:1 mL / g, and the mixture was stirred evenly and placed in a water bath and heated to 60°C for reaction; after the reaction was completed, the mixture was centrifuged at 5000 r / min for 20 minutes, and the supernatant was collected after centrifugation, and the obtained supernatant was concentrated to 1 / 3 of the original volume using a rotary evaporator, and the pH value of the concentrate was adjusted to about 7.0 again; after standing, the mixture was centrifuged at 4000 r / min for 15 minutes, and the supernatant was taken and concentrated to about 80 mL; a 12000Da dialysis bag was used to remove the small molecular substances remaining in the concentrate, and the dialysis time was a total of 24 hours, during which pure water was replaced every 6 hours; after the end, the concentrate was concentrated and centrifuged again to obtain the cactus polysaccharide concentrates extracted by the cold extraction and hot extraction methods, and stored at 4°C; Add 95% ethanol to the concentrated polysaccharide solution at a volume ratio of 1:4, stir and mix evenly, and let stand at 4°C for 12 hours; collect large precipitates after standing, centrifuge the remaining solution at 5000r / min for 5 minutes, collect the precipitate, and recover the solution; collect the collected precipitates and freeze-dry them in vacuum to obtain a cactus cold-extracted polysaccharide component group and a heat-extracted polysaccharide component group; Step (3) Extraction of Ula grass hydrosol 500 g of dried Ula grass was soaked in 8000 g of pure water for 3 hours, and then extracted at 900° C. for 3 hours to obtain a Ula grass extract, and the Ula grass extract was distilled and collected to obtain a Ula grass hydrosol; Step (4) Preparation of compound Rana sylvatica skin whitening and moisturizing ointment Prepare 100mL of 0.02mol / L KOH solution, heat it to 85°C in a water bath, keep it for 25min to sterilize and obtain an aqueous phase; weigh 30g of stearic acid, glyceryl monostearate, octadecyl alcohol and glycerol respectively and mix them evenly, heat it to 85°C in a water bath, keep it for 30min to sterilize and obtain an oil phase; when the water bath is heated to 90°C, add the aqueous phase to the oil phase while stirring, continue stirring for 50min after all are added, mix evenly to complete the saponification reaction; after the reaction is completed, continue stirring to room temperature to form a paste, let it stand fully, bottle and seal for storage, and obtain a compound forest frog skin whitening and moisturizing ointment; Step (5) Preparation of whitening, moisturizing and nourishing gel Weigh 0.8 g of carbomer, add 6 g of glycerol to it, stir evenly, then add 70 mL of distilled water, heat the mixture in a water bath to 50 °C until it swells. After complete swelling, add 1 g of lemon extract, 3 g of lily extract, 3 g of coix seed extract, 3 g of blueberry extract, 3 g of konjac extract, 3 g of bletilla striata extract, 3 g of cucumber extract, 3 g of aloe vera extract, 6 g of olive oil, 0.6 g of Tween-80, and 3 g of honey. Stir until the olive oil is evenly dispersed in the water, then add 0.08 g of triethanolamine. After stirring, add 2 mL of 70% sorbitol solution and 40 mL of distilled water, and stir again until a crystal-clear, delicate and uniform gel is formed to obtain the whitening, moisturizing and nourishing gel. Preparation of Traditional Chinese Medicine Whitening and Moisturizing Cream in Step (6) Weigh 5 g of traditional Chinese medicine whitening ingredients, 5 g of cactus polysaccharide, 15 g of pure dew of carex meyeriana, 30 g of compound Rana temporaria skin whitening and moisturizing ointment, and 5 g of whitening, moisturizing and nourishing gel respectively. After stirring for 40 min, the traditional Chinese medicine whitening and moisturizing cream is obtained.

[0035] Detection Test Comparison

[0036] According to the Light Industry Standard of the People's Republic of China (QB / T4256 - 2011), the traditional Chinese medicine whitening and moisturizing creams obtained in Examples 1 - 4 and Comparative Products 1 - 2 are detected. The specific detection methods are as follows: Test Preparation: No products (cosmetics or topical medications) can be used on the test area of the subject's hands and forearms for 2 to 3 days before the test, and water cannot be contacted for 1 to 3 hours. Before the test, the subjects need to clean the inner sides of their hands and forearms uniformly. The cleaning method is to wipe them dry with a dry paper towel.

[0037] Markings should be made on the inner sides of the subjects' hands and forearms for the measurement areas. The area of the test area should be at least 3 cm × 3 cm. Multiple areas can be marked on the same arm at the same time, and the interval between each test area should be at least 1 cm.

[0038] At least 20 minutes of quiet sitting should be done in a standard room before the formal test, and water and beverages cannot be consumed. The forearms should be exposed and placed in a test state, keeping relaxed.

[0039] Test Steps: The product application area and the blank control area should be randomly distributed in the marked areas of the left and right arms to ensure that the positions of all products and blank areas are statistically balanced.

[0040] The test sample is applied once at a dosage of (2.0 ± 0.1) mg / cm 2 . Use a latex finger cot to evenly apply the test sample in the test area, and record the actual application amount.

[0041] After adjusting the instrument according to the operating instructions of the capacitance method skin moisture meter, measure the product area and the control area, and measure at least 3 times in parallel for each area. First, measure the initial value of each test area (before using the sample), and then measure the skin moisture content of the test area and the control area after the set time. The set time should be greater than 1 h, and multiple measurement points such as 2 h and 3 h can be set according to the product evaluation needs, usually not exceeding 24 h.

[0042] The tests on the same subject must be completed by the same measurement personnel using the same instrument, and the measurement probe should be cleaned between two measurements.

[0043] If adverse reactions occur on the skin of the volunteer during the product use, the test should be terminated immediately, and the volunteer should be given appropriate treatment. The adverse reactions should be recorded.

[0044] Result determination: Positive result: Before and after the product use, there is a significant difference in the water content of the stratum corneum in the test area, indicating that the tested sample has a moisturizing effect.

[0045] Negative result: Before and after the product use, there is no significant difference in the water content of the stratum corneum in the test area, indicating that the tested sample does not have a moisturizing effect.

[0046] Table 1 Test results of skin water content after 12 h of using the traditional Chinese medicine whitening and moisturizing cream in the use examples and comparative examples

[0047] As can be seen from Table 1, the skin water content of using the traditional Chinese medicine whitening and moisturizing cream in Use Examples 1-4 is generally high, and the water content in Use Example 1 is the highest. The skin water content of using the traditional Chinese medicine whitening and moisturizing cream in Comparative Examples 1-2 is generally low, and the water content in Comparative Example 1 is the lowest.

[0048] Table 2 Test results after 12 h of using the traditional Chinese medicine whitening and moisturizing cream in the use examples and comparative examples

[0049] As can be seen from Table 2, the test results of the traditional Chinese medicine whitening and moisturizing cream in Use Examples 1-4 show positive, and the test results of the traditional Chinese medicine whitening and moisturizing cream in Comparative Examples 1-2 show negative. Since the whitening and moisturizing components in the traditional Chinese medicine whitening and moisturizing cream in the use examples contain a large number of hydrophilic groups and rich moisturizing factors, have good affinity with the surrounding tissues, and have good permeability, can be filled between the skin matrixes, have a unique effect of repairing tissues, can inhibit the water loss caused by ultraviolet irradiation, and improve the skin water condition.

[0050] This specific embodiment is only an interpretation of the present invention and is not a limitation thereof. Those skilled in the art may make modifications to this embodiment without creative contributions according to their needs after reading this specification, but as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A method for preparing a composition having whitening and moisturizing effects, characterized in that: include: Step (1) extracting whitening ingredients from traditional Chinese medicine, step (2) preparing cactus polysaccharides, step (3) preparing dendrobium officinale polysaccharides, step (4) extracting ulula grass hydrosol, step (5) preparing compound forest frog skin whitening and moisturizing ointment, step (6) preparing whitening, moisturizing and nourishing gel, and step (7) preparing traditional Chinese medicine whitening and moisturizing cream.

2. The method for preparing the composition with whitening and moisturizing effects according to claim 1, characterized in that: Step (1) Extraction of whitening ingredients from traditional Chinese medicine Select Chinese herbal medicine powders of Atractylodes macrocephala, white peony root, liquorice, kudzu root, mulberry leaf, polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamni cortex and polygonatum odoratum, use petroleum ether to ultrasonically defatted the above Chinese herbal medicine powders, use ethanol to extract each component, let the extract stand at room temperature and then reflux by microwave, filter and concentrate the filtrate, and then evaporate the concentrated filtrate to dryness, finally obtain the extract of the whitening component of the Chinese herbal medicine; Step (2) Preparation of cactus polysaccharide Wash, peel and remove the roots of fresh cactus, cut it into small pieces, put it into a wall breaking machine to break the wall until it becomes a fine paste, weigh the paste cactus and put it into a round-bottom flask, add petroleum ether thereto, put the round-bottom flask on an electric heating mantle, and assemble a reflux device; start timing when reflux occurs, and replace petroleum ether during the period; recover the filtrate after the reflux ends, wash the obtained filter residue with petroleum ether, and dry it in a water bath until the excess petroleum ether in the filter residue is dried to obtain a defatted cactus sample; Weigh a defatted cactus sample, add distilled water thereto, and soak it in cold water at room temperature while stirring; after the extraction is completed, filter out the supernatant to obtain a filter residue and a preliminarily separated supernatant, centrifuge the supernatant to separate the filter residue and the filtrate to obtain a cactus cold extraction extract, and concentrate it using a rotary evaporator to obtain a cold extraction concentrated extract; Weigh a defatted cactus sample, add distilled water thereto, and heat in a water bath for extraction; after the extraction is completed, filter out the supernatant to obtain a filter residue and a preliminarily separated supernatant, centrifuge the supernatant to separate the filter residue and the filtrate, obtain a cactus hot extraction extract, and concentrate it using a rotary evaporator to obtain a hot extraction concentrated extract; First, the pH value of the obtained cold extraction and hot extraction concentrated extract is adjusted by using NaOH solution and HCl solution, papain is added thereto, the mixture is stirred evenly, and then the mixture is placed in a water bath for heating to react, and after the reaction is completed, trichloroacetic acid solution is added thereto, the mixture is stirred evenly, and then the mixture is allowed to stand at room temperature for a certain period of time; after the standing is completed, centrifugation is performed, and after the centrifugation is completed, the supernatant is collected and concentrated; a dialysis bag is used to remove small molecular substances remaining in the concentrated solution, and after the completion, the concentrated solution is concentrated and centrifuged again to obtain cactus polysaccharide concentrated solutions obtained by the cold extraction and hot extraction extraction methods, and the concentrated solutions are stored at low temperatures; Add ethanol to the concentrated polysaccharide solution, stir and mix evenly, and let it stand at low temperature; collect large precipitates after standing, centrifuge the remaining solution, collect the precipitates again, collect the collected precipitates and freeze-dry them in vacuum to obtain cactus cold-extracted polysaccharide component groups and heat-extracted polysaccharide component groups; Step (3) Preparation of Dendrobium officinale polysaccharide The Dendrobium candidum is crushed and sieved, distilled water is added for water bath extraction, the filtrate is centrifuged to obtain the supernatant, the supernatant is concentrated under reduced pressure, ethanol is added to refrigerate the concentrated solution, the concentrated solution is centrifuged twice, the supernatant is discarded after centrifugation, and the precipitate is collected for freeze-drying to obtain the Dendrobium candidum polysaccharide; Step (4) Extraction of Ula grass hydrosol The dried Ula grass is soaked in distilled water to obtain a Ula grass extract, and the extract is distilled to obtain a Ula grass pure dew; Step (5) Preparation of compound Rana sylvatica skin whitening and moisturizing ointment Sterilize the prepared KOH solution by heating in a water bath to obtain an aqueous phase; mix stearic acid, glyceryl monostearate, octadecyl alcohol, and glycerol evenly, and sterilize by heating in a water bath to obtain an oil phase; add the aqueous phase to the oil phase and mix evenly to complete a saponification reaction; after the saponification reaction is completed, add an appropriate amount of preservative parabens and stir evenly, add forest frog skin after cooling, continue stirring until the room temperature becomes a paste, let it stand fully, bottle and seal for storage, and obtain a compound forest frog skin whitening and moisturizing cream; Step (6) Preparation of whitening, moisturizing and nourishing gel Add distilled water to carbomer and glycerin and mix evenly, heat the mixture in a water bath to swell, add lemon extract, lily extract, coix seed extract, blueberry extract, konjac extract, bletilla striata extract, cucumber extract, aloe extract, olive oil, Tween-80, honey after it is completely swollen, stir until the olive oil is evenly dispersed in the water, add triethanolamine, stir and add sorbitol solution, stir again to evenly obtain a matrix, mix ethyl paraben and ethanol evenly, add them to the matrix and stir thoroughly until a crystal clear, delicate and uniform gel is formed to obtain a whitening, moisturizing and nourishing gel; Step (7) Preparation of Chinese herbal whitening and moisturizing cream The Chinese herbal whitening ingredients extracted in step (1), the cactus polysaccharide prepared in step (2), the Dendrobium officinale polysaccharide in step (3), the Ula grass hydrosol in step (4), the compound Rana sylvatica skin whitening and moisturizing ointment in step (5) and the whitening, moisturizing and nourishing gel prepared in step (6) are fully mixed to obtain a Chinese herbal whitening and moisturizing cream.

3. The method for preparing the composition with whitening and moisturizing effects according to claim 2, characterized in that: Step (1) Extraction of whitening ingredients from traditional Chinese medicine 5-20 g each of Chinese medicine powders including Atractylodes macrocephala, white peony root, liquorice, kudzu root, mulberry leaf, polygonatum odoratum, Poria cocos, Tribulus terrestris, Dictamni cortex and polygonatum odoratum are selected, and petroleum ether is used to ultrasonically defatted the above Chinese medicine powders, and 5-15 times the amount of 40%-60% ethanol is added to extract the components, and the extract is allowed to stand at room temperature for 5-30 min and then microwave reflux is performed, and the microwave conditions are set to 400-600 W, 100-200 ° C, and 5-10 min. After filtering, the filtrate is concentrated to 1 / 15-1 / 5 of the volume of the original solution, and then the concentrated filtrate is evaporated to dryness to finally obtain an extract of Chinese medicine whitening components.

4. The method for preparing the composition with whitening and moisturizing effects according to claim 3, characterized in that: Step (2) Preparation of cactus polysaccharide Wash, peel and remove the roots of fresh cactus, cut it into small pieces, put it into a wall breaking machine to break the wall until it becomes a fine paste; accurately weigh 5-20 kg of the cactus paste and put it into a round-bottom flask, add petroleum ether according to the material-liquid ratio of 1:1-1:3 g / mL, put the round-bottom flask on an electric heating mantle, and assemble a reflux device; start timing when reflux occurs, and count for 1-2 hours each time, repeat 1-2 times, and replace the petroleum ether during the period; after the reflux is completed, recover the filtrate, wash the obtained filter residue with petroleum ether 1-3 times, heat the water bath to 50-70°C and dry it for 10-15 hours until the excess petroleum ether in the filter residue is dried, and obtain a defatted cactus sample; Weigh 4-6 kg of cactus defatted sample, add distilled water thereto at a solid-liquid ratio of 1:2-1:4 g / mL, soak in cold water at room temperature for 1-3 hours, and stir 1-2 times every 10-40 minutes; filter out the supernatant after the extraction to obtain a filter residue and a preliminarily separated supernatant, and then centrifuge the supernatant at 3000-5000 r / min for 5-20 minutes to thoroughly separate the filter residue and the filtrate to obtain a cactus cold extraction extract, take 500-1500 mL of the cold extraction extract and concentrate it to 1 / 10-1 / 2 of the original volume using a rotary evaporator at 60-70° C. to obtain a cold extraction concentrated extract; Weigh 4-6 kg of defatted cactus sample, add distilled water according to a solid-liquid ratio of 1:4-1:1 g / mL, and extract by heating in a water bath at 80-100° C. for 1-3 hours; after the extraction, filter out the supernatant to obtain a filter residue and a preliminarily separated supernatant, centrifuge the supernatant at 3000-5000 r / min for 5-20 minutes to completely separate the filter residue and the filtrate to obtain a cactus hot extraction extract, take 500-1500 mL of the hot extraction extract and concentrate it to 1 / 10-1 / 2 of the original volume using a rotary evaporator at 60-70° C. to obtain a hot extraction concentrated extract; First, the pH value of the cold extraction and hot extraction concentrated extract obtained is adjusted to about 5.0-7.0 using NaOH solution and HCl solution, papain is added thereto at a liquid-to-solid ratio of 100:1-20:1 mL / g, the mixture is stirred evenly, and then placed in a water bath and heated to 40-60° C. for reaction, after the reaction is completed, 2.0-4.0% trichloroacetic acid solution is added thereto at a volume ratio of 1:1-1:2, stirred evenly, and then allowed to stand at room temperature for 20-40 minutes; after the standing, the mixture is heated at 3000-5000 r / min. Centrifuge for 5-20 minutes under the conditions, collect the supernatant after centrifugation, concentrate the obtained supernatant to 1 / 2-1 / 3 of the original volume by rotary evaporator, and adjust the pH value of the concentrate to about 5.0-7.0 again; take a dialysis bag of 8000-14000Da to remove the small molecular substances remaining in the concentrate, and the dialysis time is 20-32h in total, and the pure water is replaced 1-2 times every 4-8h during the dialysis period; after the end, concentrate and centrifuge the concentrate again to obtain the cactus polysaccharide concentrate extracted by cold extraction and hot extraction, and store at 2-6℃; Add 95% ethanol to the concentrated polysaccharide solution at a volume ratio of 1:1-1:6, stir and mix evenly, and let stand at 2-6°C for 10-16 hours; collect large precipitates after standing, centrifuge the remaining solution at 3000-5000r / min for 5-20min, collect the precipitate, and recover the solution; aggregate the collected precipitates and perform vacuum freeze-drying to obtain a cactus cold-extracted polysaccharide component group and a hot-extracted polysaccharide component group.

5. The method for preparing the composition with whitening and moisturizing effects according to claim 4, characterized in that: Step (3) Preparation of Dendrobium officinale polysaccharide The Dendrobium officinale is crushed and sieved, distilled water is added at a solid-liquid ratio of 1:20-1:30 g / mL, and the mixture is extracted in a water bath at 60-100° C. for 1-3 times. The filtrate is centrifuged at 4000-6000 r / min for 5-20 min, the supernatant is taken after centrifugation, and it is concentrated under reduced pressure at 40-80° C., 3-5 times the volume of ethanol is added to refrigerate the concentrate at 2-6° C. The concentrate is centrifuged 1-2 times at 6000-10000 r / min for 5-20 min, the supernatant is discarded after centrifugation, the precipitate is collected and freeze-dried at -50~-60° C., and Dendrobium officinale polysaccharide is obtained.

6. The method for preparing the composition having whitening and moisturizing effects according to claim 5, characterized in that: Step (4) Extraction of Ula grass hydrosol Take 400-600g of dried Ula grass and soak it with 8000-9000g of pure water for 1-3h, extract it at 80-100℃ for 1-3h to obtain Ula grass extract, and distill and collect the Ula grass extract to obtain Ula grass pure water.

7. The method for preparing the composition having whitening and moisturizing effects according to claim 6, characterized in that: Step (5) Preparation of compound Rana sylvatica skin whitening and moisturizing ointment The method comprises the following steps: preparing a 0.01-0.02 mol / L 100-200 mL KOH solution, heating the solution to 80-90° C. in a water bath, and sterilizing the solution for 10-30 minutes to obtain a water phase; weighing 10-30 g of stearic acid, glyceryl monostearate, octadecyl alcohol, and glycerol respectively, mixing the mixture evenly, heating the solution to 80-90° C. in a water bath, and sterilizing the mixture for 10-30 minutes to obtain an oil phase; adding the water phase to the oil phase while stirring the mixture when the mixture is heated to 80-90° C., stirring the mixture for 40-50 minutes after the mixture is fully added, and mixing the mixture evenly to complete a saponification reaction; after the saponification reaction is completed, adding 5-10 g of a preservative paraben and stirring the mixture for 20-25 minutes, cooling the mixture to 40-50° C., adding 5-15 g of forest frog skin, and continuing to stir the mixture until the mixture becomes a paste at room temperature, allowing the mixture to stand for a long time, and sealing the mixture in a bottle for storage to obtain a compound forest frog skin whitening and moisturizing cream.

8. The method for preparing the composition with whitening and moisturizing effects according to claim 7, characterized in that: Step (6) Preparation of whitening, moisturizing and nourishing gel Weigh 0.2-0.8g of carbomer, add 5-8g of glycerol thereto, stir evenly, add 60-80mL of distilled water, heat in a water bath to 40-60°C to swell the mixture, add 1-2g of lemon extract, 2-4g of lily extract, 2-4g of coix seed extract, 2-4g of blueberry extract, 2-4g of konjac extract, 2-4g of bletilla striata extract, 2-4g of cucumber extract, 2-4g of aloe extract, 4-8g of olive oil, 0.5-1g of Tween-80, 2-4g of honey, stir until the olive oil is evenly dispersed in the water, add 0.05-0.1g of triethanolamine, stir, add 2-3mL of 60%-70% sorbitol solution and 40-45mL of distilled water, stir evenly again to obtain a matrix, dissolve 0.3-0.5g of ethyl p-hydroxybenzoate in 5-15mL Add to 90%-95% ethanol and mix evenly, add to the base and stir thoroughly until a crystal clear, delicate and uniform gel is formed to obtain a whitening, moisturizing and nourishing gel.

9. The method for preparing the composition with whitening and moisturizing effects according to claim 8, characterized in that: Step (7) Preparation of Chinese herbal whitening and moisturizing cream Weigh 5-15g of traditional Chinese medicine whitening ingredients, 5-15g of cactus polysaccharide, 10-30g of Dendrobium officinale polysaccharide, 5-15g of Ula grass hydrosol, 10-30g of compound Rana silene peel whitening and moisturizing ointment, and 5-15g of whitening, moisturizing and nourishing gel respectively, stir for 20-40 minutes, and obtain the traditional Chinese medicine whitening and moisturizing cream.

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