Micro-nanocrystallization production method and equipment system for medicinal materials

Abstract

The invention provides a medicinal material micro-nanocrystallization production method and equipment system, and the medicinal material micro-nanocrystallization production method and equipment system comprises the following steps: after medicinal materials are compatible, extracting medicinal slurry by a water extraction and alcohol extraction method, firstly filling the medicinal slurry into a biochemical hydrolysis tank for biochemical hydrolysis, the medicinal slurry is converted into medicinal hydrolysate; carrying out biochemical hydrolysis treatment on the medicinal hydrolysate by adopting a preset treatment mode, inputting the treated medicinal hydrolysate into a cyclic shearing and filtering linkage unit to carry out cyclic shearing and filtering, and returning medicinal filter residues obtained after shearing and filtering to the biochemical hydrolysis step to carry out biochemical hydrolysis again; and carrying out ultrasonic enhanced dispersion on the qualified medicinal hydrolysate under the action of ultrasonic waves, and then conveying to a micro-nano traditional Chinese medicine finished product line for storage, metering and packaging. The micro-molecular traditional Chinese medicine oral liquid with the particle size reaching the micro-nano level is produced and can be quickly absorbed by a human body, and the micro-nano oral liquid is better in taste and efficacy.

Description

Technical Field

[0001] The present invention relates to the technical field of processing of medicinal materials including traditional Chinese medicines and health foods and health products with the same origin as medicines and foods, and particularly relates to a production method for micronizing and nanonizing medicinal materials. Background Art

[0002] At present, the temperature for water extraction after single or combined traditional Chinese medicines are pulverized is 70°C - 100°C, and then the temperature for ethanol extraction does not exceed 80°C. They are macromolecules larger than the micron and nanometer levels, and are slowly absorbed by the human body, with slow onset of drug effects. It is necessary to take continuously or for a long time for a certain period to take effect.

[0003] The principle of the conventional solvent extraction method for traditional Chinese medicine extraction technology and the extraction equipment is to select a solvent with a large solubility for the active ingredients and a small solubility for the ingredients that do not need to be dissolved out according to the solubility properties of various components in the solvent in traditional Chinese herbs, so as to dissolve the required target components from the medicinal material tissue. However, because the degree of microquantization of the active ingredients by this method is insufficient, the absorption effect of the traditional Chinese medicine liquid is also greatly reduced.

[0004] Taking the patent with the publication number CN104289294 as an example, it only discloses a conventional microquantization pulverization method for traditional Chinese medicines. At present, there is no method or device that can effectively solve the problem of how to make the traditional Chinese medicine compatibility aqueous solution reach the micron and nanometer levels and be more easily absorbed. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a production method for micronizing and nanonizing traditional Chinese medicines and health foods and health products with the same origin as medicines and foods.

[0006] Based on the above purpose, the present invention provides a production method for micronizing and nanonizing medicinal materials, including:

[0007] Single or combined medicinal materials are extracted to obtain a medicinal slurry by the water extraction and ethanol extraction method, and a preset treatment method is adopted to perform biochemical hydrolysis treatment on the traditional Chinese medicine so as to convert the medicinal slurry into a medicinal hydrolyzate;

[0008] The treated medicinal hydrolyzate is subjected to cyclic shearing and filtration, and the medicinal filter residue obtained after shearing and filtration is returned to the biochemical hydrolysis step for re-hydrolysis;

[0009] The medicinal hydrolyzate is ultrasonically enhanced and dispersed, and is transported to the micron and nano traditional Chinese medicine finished product line for storage, metering and packaging.

[0010] Based on another object of the present invention, the treatment of the medicinal hydrolysis solution by adopting a preset treatment method includes: controlling various indexes of the medicinal hydrolysis solution in an intelligent manner, with the controlled temperature range being 70°C - 130°C, the pressure range being 0.5 mpa - 1.3 mpa, the biochemical hydrolysis time being 0.5 h - 4 h, and the dosage of the biochemical promoter being controlled to keep the pH value of the medicinal hydrolysis solution at 2 - 4.

[0011] Based on another object of the present invention, the cyclic shearing and filtration of the treated medicinal hydrolysis solution includes:

[0012] The rotation speed of the cyclic shearing controlled by intelligent control is 3000 r / min - 10000 r / min, the filtration speed is 10 m / h - 30 m / h, and the cyclic shearing and cyclic filtration time is 0.5 h - 4 h, so that the micron-sized particles in the finally formed medicinal product account for 10% - 30%, and the nano-sized particles account for 90% - 70%.

[0013] Based on another object of the present invention, it further includes a heat recovery and utilization step:

[0014] Recover and recycle the heat carried by the medicinal hydrolysis solution in the cyclic shearing stage, and provide heat energy for the heating required in the biochemical hydrolysis stage through the heat exchange equipment system.

[0015] Based on another object of the present invention, the ultrasonic enhanced dispersion of the mixed medicinal hydrolysis solution includes: in the ultrasonic enhanced dispersion controlled by intelligent control, the frequency of the ultrasonic wave is controlled at 10 kHz - 40 kHz, the sound intensity is controlled at 1 w / cm 2 —30 w / cm 2 , and the dosage of the dispersant is 0.05% - 0.3%.

[0016] As can be seen from the above, the production method for micronanometerization of the medicinal material provided by the present invention enables the oral liquid of single Chinese herbal medicine or the combined Chinese herbal medicine after water extraction and alcohol extraction to undergo a series of processes such as biochemical hydrolysis, cyclic shearing, filtration, and ultrasonic enhanced dispersion and stabilization, producing a small molecule Chinese medicine oral liquid with a particle size reaching the micronanometer level, which is quickly absorbed by the human body, and the taste of the micronanometer-level oral liquid is improved. Compared with conventional decoction or extraction, the efficacy of the finally formed oral liquid can be manifested faster, and the dosage and treatment course of the medicine are correspondingly reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the present invention or related technologies, the following will briefly introduce the drawings required for use in the embodiments or related technology descriptions. Obviously, the drawings in the following description are only the embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0018] Figure 1 It is a schematic flow chart of the production method for micronizing and nanonizing medicinal materials in the embodiments of the present invention;

[0019] Figure 2 It is a schematic flow chart of the production method for micronizing and nanonizing medicinal materials in the embodiments of the present invention;

[0020] Figure 3 It is a schematic side view of the biochemical hydrolysis tank in the embodiments of the present invention;

[0021] Figure 4 It is a schematic top view of the biochemical hydrolysis tank in the embodiments of the present invention. Specific Embodiments

[0022] To make the objectives, technical solutions, and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below with reference to specific embodiments and the accompanying drawings.

[0023] It should be noted that unless otherwise defined, the technical terms or scientific terms used in the embodiments of the present invention should have the ordinary meanings understood by those of ordinary skill in the field to which the present invention belongs. The "first", "second", and similar terms used in the embodiments of the present invention do not indicate any order, quantity, or importance, but are only used to distinguish different components. The terms such as "including" or "comprising" mean that the elements or objects appearing before this word cover the elements or objects listed after this word and their equivalents, without excluding other elements or objects. The terms such as "connected" or "coupled" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The terms such as "upper", "lower", "left", "right", etc. are only used to represent relative positional relationships, and when the absolute position of the object being described changes, the relative positional relationship may also change accordingly.

[0024] It should be noted that a single medicinal material refers to a certain traditional Chinese medicine with medicinal properties (such as ginseng, tangerine peel, etc.); the traditional Chinese medicine compatibility water is the traditional Chinese medicine liquid formed by boiling or extracting 2 or more kinds of medicinal materials with similar, opposite, assisting, or matching effects according to the traditional Chinese medicine formula according to certain rules and traditional Chinese medicine pharmacology.

[0025] Medicinal materials refer to traditional Chinese medicine herbs, as well as single or multiple materials of food and health products with the same origin as medicine and food, such as the types of food and medicine substances specified in the "Catalogue of Substances with the Same Origin as Medicine and Food".

[0026] The present invention is applicable to some scenarios where medicinal materials are micronized and nanonized to make the efficacy of the medicinal materials better.

[0027] In the exemplary embodiments of the present invention, in combination with Figure 1 and Figure 2As shown, the production method for micronization and nanonization of medicinal materials of the present invention mainly includes the following steps:

[0028] In step 110, the single or combined medicinal materials are extracted to obtain a medicinal slurry by the water extraction and alcohol precipitation method, and a preset treatment method is adopted to treat the medicinal hydrolysis solution so that the medicinal slurry is converted into a medicinal hydrolysis solution;

[0029] The single or combined medicinal materials, and / or the single or combined herbs and the medicinal and edible homologous food and health product materials after compatibility, and / or the medicinal slurry or the medicinal and edible homologous food and health product slurry or the medicinal and edible homologous food and health product slurry extracted by the water extraction and alcohol precipitation method (for the convenience of description, hereinafter uniformly referred to as the medicinal slurry).

[0030] The single or combined medicinal materials are subjected to water extraction and alcohol precipitation to obtain a medicinal slurry. The process of the water extraction and alcohol precipitation method includes: decoction method, maceration method, percolation method, reflux method, filtration and separation method and other water extraction and alcohol precipitation methods and processes.

[0031] The medicinal slurry is subjected to biochemical hydrolysis, and the medicinal slurry is transferred to a biochemical hydrolysis tank for reaction. The biochemical hydrolysis tank refers to: a device and equipment that meets the requirements of design pressure, temperature, pressurization, heating, batching, etc. and conducts biochemical reactions on the materials. Combined with Figure 3 the side view of the biochemical hydrolysis tank shown in Figure 4 and the top view of the biochemical hydrolysis tank shown in, it has a certain volume for treating medicinal materials, and subsystems such as pressurization, heating, batching, stirring, etc. and a circulating shear filtration combined unit are set up for further treatment of the medicinal slurry.

[0032] During the biochemical hydrolysis process, the energy-saving method of an overpressure saturated water heat pump can be preferably used to heat the biochemical hydrolysis, and the temperature, pressure, hydrolysis time and the dosage of biochemical promoters, etc. are controlled intelligently.

[0033] Among them, the preferred energy-saving method of the overpressure saturated water heat pump refers to: the relationship between the overpressure saturated water heat pump and the biochemical hydrolysis tank is that the overpressure saturated water heat pump is used to heat the materials in the biochemical hydrolysis tank according to the predetermined requirements such as energy saving, stability, continuity and relatively constant temperature.

[0034] The so-called biochemical hydrolysis refers to transporting the medicinal slurry to the biochemical hydrolysis tank through a transfer pump, adding a promoter, and using an intelligent control heat pump to heat and pressurize the biochemical hydrolysis materials. The temperature is 70°C - 130°C, the pressure is 0.5 mpa - 1.3 mpa, the biochemical hydrolysis time is 0.5 h - 4 h, and the dosage of the biochemical promoter is controlled by a pH value of 2 - 4.

[0035] In step 120, the medicated hydrolysis liquid is processed by a preset processing method, and the processed medicated hydrolysis liquid is subjected to cyclic shearing and filtration. The medicated filter residue obtained after shearing and filtration is returned to the biochemical hydrolysis step for re-hydrolysis, and the filter residue hydrolysis liquid is mixed into the medicated slurry; and the heat of the medicated hydrolysis liquid is recycled during the cyclic shearing process.

[0036] Specifically, in an implementable scenario of an exemplary embodiment of the present invention, the taking of the preset processing method to process the medicated hydrolysis liquid includes: controlling various indexes of the medicated hydrolysis liquid such as temperature, pressure, time, and pH value of the liquid medicine. The controlled temperature range is 70°C - 130°C, the pressure range is 0.5 mpa - 1.3 mpa, the biochemical hydrolysis time is 0.5 h - 4 h, and the addition amount of the biochemical promoter is controlled to keep the pH value of the medicated hydrolysis liquid at 2 - 4.

[0037] The intelligent control method refers to that the present invention provides a systematic device, which includes: automatic sensors, automatic valve control, automatic flow control, automatic temperature control, automatic time control, automatic pressure control, automatic batching control, automatic liquid level control, automatic stirring control, automatic particle size detection control, automatic pH value detection control, automatic packaging control, etc., and the linkage control of one or more devices according to a predetermined program, etc.

[0038] Each device of the above intelligent control can respectively receive instructions from the upper computer to control the weight, quality, temperature, pressure, reaction time, pH value detection, particle size detection, etc. of the liquid according to the established process.

[0039] The rotation speed of the intelligent control mechanical force circulation shearing machine and the speed of the filter are controlled, and a laser particle size analyzer is used to detect the particle diameter of the filtrate. The filter residue that does not meet the detection standard is returned to be mixed with the new material for re-hydrolysis, and this is repeated until there is no residue of the filter residue.

[0040] Based on another object of the present invention, it further includes a heat recovery and utilization step:

[0041] The heat carried by the medicated hydrolysis liquid in the cyclic shearing stage is recovered and recycled, and heat energy is provided to the heating required in the biochemical hydrolysis stage through the heat exchange equipment system.

[0042] In step 130, the mixed medicated hydrolysis liquid is ultrasonically enhanced and dispersed, and then transported to the micro-nano traditional Chinese medicine finished product line for storage, metering, and packaging.

[0043] Due to the complex composition of the medicinal materials in the medicinal hydrolysis solution, it is relatively easy to re-polymerize and agglomerate under normal circumstances. The ultrasonic strengthening and dispersion of the medicinal hydrolysis solution in the present invention can greatly reduce or decrease the occurrence of re-polymerization and agglomeration of the micro-nano-sized hydrolysis solution substances, making the finally produced micro-nano-sized medicinal liquid easier to be absorbed and utilized.

[0044] From product storage to product metering and packaging, the packaging quantity and the conveying speed of the packaged product are controlled intelligently and set according to user requirements; storage, metering, and packaging are all conveyed by a conveying pump, and the rotation speed and conveying volume of the conveying pump are controlled intelligently.

[0045] Perform ultrasonic strengthening and dispersion on the filtrate, and control the ultrasonic frequency, sound intensity, and the addition amount of the dispersant.

[0046] In a feasible implementation manner of an exemplary embodiment of the present invention, the cyclic shearing and filtration of the processed medicinal hydrolysis solution includes:

[0047] Use a shearing machine with intelligent control for cyclic shearing, with a shearing rotation speed of 3000 r / min - 10000 r / min (revolutions per minute) and a filtration speed of 10 m / h - 30 m / h (meters per hour). The filtration speed needs to be set according to the volume of the medicinal hydrolysis solution. The cyclic shearing and cyclic filtration time is 1 h - 4 h, so that the micron-sized particles of the finally formed medicinal finished product account for 10% - 30%, and the nano-sized particles account for 90% - 70%.

[0048] In this step, the micron-sized particles of the finally formed medicinal finished product account for 10% - 30%, and the nano-sized particles account for 90% - 70%: The nano-sized particle size is more conducive to the rapid absorption by the human body system and reduces the decomposition burden on the human gastrointestinal tract. A certain amount of micron-sized particles will be further decomposed and absorbed after entering the human gastrointestinal tract, which is beneficial to maintaining the vitality of the gastrointestinal tract decomposition, digestion, and absorption functions.

[0049] In a feasible implementation manner of an exemplary embodiment of the present invention, the ultrasonic strengthening and dispersion of the mixed medicinal hydrolysis solution includes: In the ultrasonic strengthening and dispersion controlled by intelligence, the ultrasonic frequency is controlled at 10 kHz - 40 kHz, and the sound intensity is controlled at 1 w / cm 2 —30 w / cm 2 , and the addition amount of the dispersant is 0.05% - 0.3%.

[0050] In the present invention, ultrasonic strengthening and dispersion can greatly reduce or decrease the re-polymerization and agglomeration of micro-nano-sized hydrolysis solution substances.

[0051] In a more preferred implementation manner of the present invention, the frequency is controlled at 10 kHz - 40 kHz, and the sound intensity is controlled at 1 w / cm 2 —30 w / cm 2, the dosage of the dispersant is 0.05%-0.3%, and the absorption effect and appearance of the finally formed pharmaceutical products are better.

[0052] Specific embodiments of the exemplary embodiments of the present invention include:

[0053] The aqueous extract or slurry of traditional Chinese medicine is transported to the biochemical hydrolysis tank by intelligent control, a promoter is added, and the biochemical hydrolysis is heated and pressurized by an intelligent control heat pump. The temperature is controlled at 115°C, the pressure is controlled at 0.5 mpa, the biochemical hydrolysis time is 1.5 h, and the dosage of the promoter is controlled according to the pH value of 2.5.

[0054] The rotation speed of the circulating shearing device is controlled by intelligent control at 4000 rpm, the circulating filtration speed controlled by intelligent control is 10 m / h, and the circulating filtration time is 1.5 h.

[0055] The measured value of the micron-sized particles is on average 1.4 microns, accounting for 28.6%, and the measured average of the nano-sized particles is 40 nanometers, accounting for 71.4%.

[0056] The ultrasonic frequency controlled by intelligent control is 20 kHz, and the sound intensity is 10 w / cm 2 .

[0057] The dosage of the dispersant is one-thousandth.

[0058] The rotation speed of the delivery pump controlled by intelligent control to each system is 1000 rpm.

[0059] Specific embodiments of the exemplary embodiments of the present invention include:

[0060] The aqueous extract or slurry of traditional Chinese medicine is transported to the biochemical hydrolysis tank by intelligent control, a promoter is added, and the biochemical hydrolysis material is heated and pressurized by an intelligent control heat pump. The temperature is controlled at 120°C, the pressure is controlled at 0.8 mpa, the biochemical hydrolysis time is 2.0 h, and the addition of the promoter is controlled according to the pH value of 3.

[0061] The rotation speed of the circulating shearing device is controlled by intelligent control at 6000 rpm, the circulating filtration speed controlled by intelligent control is 15 m / h, the circulating filtration time is 2.5 h, the measured average of the micron-sized particles is 1.24 microns, accounting for 16.7%, and the measured value average of the nano-sized particles is 347 nanometers, accounting for 83.3%.

[0062] It should be noted that some embodiments of the present invention have been described above. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recited in the claims may be performed in a different order than in the above embodiments and still achieve the desired results. Additionally, the processes depicted in the drawings do not necessarily require the particular order or sequential order shown to achieve the desired results. In certain embodiments, multitasking and parallel processing are also possible or may be advantageous.

[0063] Based on the same inventive concept, corresponding to any of the above-described method embodiments, the present invention further provides a production device for micronanometerization of medicinal materials, which device includes: a heating equipment system, a pressurizing equipment system, a batching equipment system, a biochemical hydrolysis equipment system, a circulating shearing equipment system, a filtering equipment system, an ultrasonic equipment system, an automatic detection equipment system for weight, pH value, particle size, etc., an automatic canning equipment system, an intelligent automation control system, etc., so as to implement the above-described production method for micronanometerization of medicinal materials.

[0064] Embodiments of the present invention are intended to cover all such substitutions, modifications, and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the embodiments of the present invention shall be included within the protection scope of the present invention.

Claims

1. A method for producing micro-nano pharmaceutical materials, characterized in that: The production method of the micro-nano pharmaceutical material comprises: Extracting medicinal slurry from single or combined medicinal materials by water extraction or alcohol extraction, and subjecting the traditional Chinese medicine to biochemical hydrolysis in a preset manner to convert the medicinal slurry into a medicinal hydrolyzate; The medicinal hydrolyzate is cyclically sheared and filtered, and the filter residue obtained after shearing and filtering is returned to the biochemical hydrolysis step for re-hydrolysis; The medicinal hydrolyzate is dispersed by ultrasonic enhancement and transported to the micro-nano Chinese medicine finished product line for storage, measurement and packaging.

2. The method for producing micro-nano pharmaceutical materials according to claim 1, characterized in that: The medicinal hydrolyzate is treated in a preset treatment method, including: controlling various indicators of the medicinal hydrolyzate in an intelligent manner, the controlled temperature range is 70°C-130°C, the pressure range is 0.5mpa-1.3mpa, the biochemical hydrolysis time is 0.5h-4h, and the amount of biochemical promoter is added to keep the pH value of the medicinal hydrolyzate at 2-4 for control.

3. The method for producing micro-nano pharmaceutical materials according to claim 1, characterized in that: The method of cyclically shearing and filtering the treated medicinal hydrolyzate comprises: The number of revolutions of the intelligently controlled circulating shear is 3000r / min-10000r / min, the filtering speed is 10m / h-30m / h, and the circulating shearing and filtering time is 0.5h-4h, so that the particle size of the final medicinal product is 10%-30% in the micron level and 90%-70% in the nanometer level.

4. The method for producing micro-nano pharmaceutical materials according to claim 1, characterized in that: The mixed medicinal hydrolyzate is subjected to ultrasonic enhanced dispersion, including: the frequency of the ultrasonic wave in the ultrasonic enhanced dispersion is controlled to be 10kHz-40kHz by intelligent control, and the sound intensity is controlled to be 1w / cm 2 —30w / cm 2 , the amount of dispersant added is 0.05%-0.3%.

5. The method for producing micro-nano pharmaceutical materials according to claim 1, characterized in that: It also includes heat recovery steps: The heat of the medicinal hydrolyzate in the cyclic shearing stage is recovered and recycled, and the heat energy required for heating in the biochemical hydrolysis stage is provided through a heat exchange equipment system.

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