A liquid bandage and its preparation method

Abstract

This invention relates to the field of medical dressing technology, and more particularly to a liquid wound dressing and its preparation method. The preparation method includes the following steps: Sodium chloride and sodium citrate are added to water according to the formula to obtain mixture A; copper gluconate is added to mixture A to form mixture B; Tween 20 and glycerin are mixed, L-menthol is added, and the mixture is stirred to form mixture C; mixture C is added to mixture B to form mixture D; acetic acid is added to water, mixed, and then chitosan is added and dissolved to obtain a chitosan-acetic acid solution; the chitosan-acetic acid solution is added to mixture D and dissolved to form mixture E; the pH of mixture E is adjusted to 4.5-6.5, filtered, filled, and sterilized to obtain the liquid wound dressing. The liquid wound dressing prepared by this invention can quickly form a protective film on the wound surface, effectively inhibiting bacterial growth, promoting wound healing, and also has good flexibility and comfort with low irritation.

Description

Technical Field

[0001] This invention relates to the field of medical dressing technology, and more particularly to a liquid wound dressing and its preparation method. Background Technology

[0002] Traditional adhesive bandages are typically sheet-like, consisting of an absorbent layer, an adhesive layer, and a release layer. While widely used in daily life, they have some drawbacks. For example, traditional bandages have limited adhesion and tend to fall off at joints and other active areas, failing to effectively cover and protect the wound. Furthermore, they have poor breathability, and prolonged use can lead to a hot and moist environment around the wound, promoting bacterial growth and hindering healing.

[0003] There are some liquid bandage products on the market, but most of them require ethanol as a solvent, which poses a problem of strong skin irritation.

[0004] Therefore, how to provide a liquid wound dressing with low skin irritation is a technical problem that urgently needs to be solved. Summary of the Invention

[0005] To address the problem of strong skin irritation caused by existing liquid wound dressings, this invention provides a method for preparing a liquid wound dressing. This method provides an ethanol-free solvent-based liquid wound dressing that improves antibacterial properties and rapid film-forming properties while reducing skin irritation, thus solving the problem of strong skin irritation caused by existing liquid wound dressings.

[0006] The technical solution adopted by this invention to solve its technical problem is:

[0007] A method for preparing a liquid wound dressing includes the following steps:

[0008] S1: Add sodium chloride and sodium citrate to water according to the formula, dissolve them, and obtain mixture A;

[0009] S2: Add copper gluconate to mixture A to form mixture B;

[0010] S3: Mix Tween 20 with glycerin, add L-menthol, and stir to form mixture C;

[0011] S4: Add the mixture C to the mixture B to form mixture D;

[0012] S5: Add acetic acid to water, mix well, then add chitosan and dissolve to obtain a chitosan-acetic acid solution;

[0013] S6: Add the chitosan-acetic acid solution to the mixture D, dissolve, and form mixture E;

[0014] S7: Adjust the pH of the mixture E to 4.5-6.5, filter, fill, sterilize, and obtain a liquid wound dressing.

[0015] Optionally, the amount of sodium chloride added in step S1 is 0.5-1.5 parts by weight.

[0016] Optionally, the amount of sodium citrate added in step S1 is 0.2-1.5 parts by weight.

[0017] Optionally, the amount of copper gluconate added in step S2 is 0.01-0.5 parts by weight.

[0018] Optionally, the amount of L-menthol added in step S3 is 0.1-2 parts by weight.

[0019] Optionally, the amount of glycerol added in step S3 is 3-15 parts by weight.

[0020] Optionally, the amount of Tween 20 added in step S3 is 0.4-3 parts by weight.

[0021] Optionally, the amount of acetic acid added in step S5 is 0.5-3 parts by weight.

[0022] Optionally, the amount of chitosan added in step S5 is 1-3 parts by weight.

[0023] Another object of the present invention is to provide a liquid bandage, which is prepared by the liquid bandage preparation method described above.

[0024] The beneficial effects of this invention are:

[0025] The liquid wound dressing preparation method provided by this invention can quickly form a protective film on the wound surface, effectively inhibiting bacterial growth and promoting wound healing. At the same time, it has good flexibility and comfort, and low irritation, solving the problems of weak antibacterial properties, strong irritation, and slow film formation of existing wound dressings. Detailed Implementation

[0026] The present invention will now be described in further detail. The embodiments described below are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0027] To address the problem of strong skin irritation caused by existing liquid wound dressings, this invention provides a method for preparing a liquid wound dressing, which includes the following steps:

[0028] S1: Add sodium chloride and sodium citrate to water according to the formula amount, and stir / sonicate until completely dissolved to obtain mixture A;

[0029] S2: Slowly add copper gluconate to mixture A, and use stirring / ultrasound or other methods to fully dissolve the copper gluconate in the solution to form mixture B;

[0030] S3: Mix Tween 20 and glycerin evenly, add L-menthol, and stir thoroughly to form mixture C;

[0031] S4: Slowly add mixture C to mixture B, and use stirring / ultrasound or other methods to fully mix the components to form mixture D;

[0032] S5: Add acetic acid to water, mix well, then add chitosan, and dissolve it by stirring / ultrasound to obtain a chitosan-acetic acid solution;

[0033] S6: Slowly add the chitosan-acetic acid solution to mixture D, and ensure that the chitosan is completely dissolved and uniformly dispersed by stirring / sonication to form mixture E;

[0034] S7: Adjust the pH of mixture E to 4.5-6.5, preferably to 5.0-5.8, using acetic acid solution or sodium citrate. Filter, fill, and sterilize to obtain liquid wound dressing.

[0035] The preparation method and mechanism of action of this liquid bandage are as follows:

[0036] 1. Chitosan solubility and system stability:

[0037] (1) Amino protonation aids solubilization: The amino group (-NH2) in chitosan molecules is protonated into a positively charged ammonium group (-NH3) in acetic acid solution. + Chitosan is dissolved by disrupting the hydrogen bond network between molecular chains through charge repulsion.

[0038] (2) Formation of ionic cross-linking network: gluconate (C 12 H 21 O 14 - ) and protonated chitosan (-NH3) + A dynamic ionic cross-linking network is formed through electrostatic interaction, which improves the homogeneity of the solution and the stability of the film formation, and avoids the precipitation of chitosan due to pH fluctuations.

[0039] (3) Chelation: Chitosan carries a positive charge (-NH3) in acidic solutions. + If in direct contact with Cu 2+ Electrostatic adsorption occurs, leading to aggregation. Citrate ions (C6H5O7) 3- ) Chelating Cu² + Then, its positive charge is neutralized to ensure the system is uniform and stable.

[0040] (4) pH control: Sodium citrate and acetic acid form a buffer system to maintain a pH of 4.5-6.5 (preferably 5.0-5.8), ensuring chitosan dissolution while avoiding excessive acidification that could irritate the skin. This also helps prevent Cu... 2+ It is inactivated under excessively acidic or alkaline conditions.

[0041] 2. Synergistic antibacterial effect (charge-coordinated antibacterial action):

[0042] (1) The antibacterial mechanism of chitosan:

[0043] A. Charge adsorption: Chitosan carries a positive charge (-NH3). + (This) binds to the bacterial cell membrane (which carries a negative charge) through electrostatic interactions, disrupting membrane permeability.

[0044] B. Membrane damage: After chitosan penetrates into the cell, it interferes with DNA / RNA transcription and protein synthesis.

[0045] (2) Cu² + Antibacterial mechanism:

[0046] A. Generates reactive oxygen species (ROS): Cu² + The Fenton reaction generates hydroxyl radicals (·OH), which oxidatively damage cell membranes, proteins, and nucleic acids.

[0047] B. Enzyme activity inhibition: It binds to the sulfhydryl groups (-SH) in microbial enzymes, blocking metabolic pathways.

[0048] (3) Synergistic enhancement effect:

[0049] The positive charge of chitosan (-NH3) + After adsorbing onto the bacterial surface and disrupting the cell membrane barrier, Cu² + It is easier to enter the cell, amplifying the generation of ROS and the enzyme inhibition effect.

[0050] 3. Optimization of film-forming properties:

[0051] (1) Glycerol-Tween 20 synergistic plasticization:

[0052] A. Glycerol binds to chitosan molecular chains through hydrogen bonds, lowering the glass transition temperature and enhancing membrane flexibility;

[0053] B. Tween 20 reduces the surface tension of the solution, promotes the uniform spread of the liquid on the wound surface, and shortens the film formation time to 2-4 minutes.

[0054] (2) Osmotic pressure adaptation: Sodium chloride adjusts the osmotic pressure of the solution to 280-320 mOsm / kg (similar to human tissue fluid), reducing osmotic pressure stress on wound cells and improving user comfort.

[0055] (3) Improved mechanical properties: Chitosan is protonated in the acetic acid solution system to form positively charged ammonium ions (-NH3). + The dissociation of copper gluconate produces gluconate ions. The combination of ammonium ions and gluconate ions can form an ionic cross-linking network, which improves the mechanical properties of the membrane.

[0056] 4. Improved biocompatibility: The reaction between sodium citrate and copper gluconate can reduce free Cu²⁺. + The concentration reduced the cytotoxicity of the dressing.

[0057] The method for preparing liquid wound dressing provided by this invention has the following advantages compared with the prior art:

[0058] 1. Excellent antibacterial properties: The combination of chitosan (natural antibacterial) and copper gluconate (broad-spectrum antibacterial) enhances the antibacterial effect, while multi-target action (membrane damage, ROS oxidation, enzyme inhibition) reduces the risk of drug resistance caused by a single antibacterial mechanism.

[0059] 2. Rapid film formation: The liquid bandage formulated with this product can form a film in as little as 2-4 minutes. It provides timely protection for wounds and adapts to irregular wound surfaces.

[0060] 3. Biosafety assurance:

[0061] (1) Low irritation: Ethanol-free solvent system, with low skin irritation;

[0062] (2) Good biocompatibility: Sodium citrate reacts with copper gluconate to reduce free Cu²⁺. + The concentration reduced the cytotoxicity of the dressing.

[0063] 4. High comfort: The cooling sensation from L-menthol can relieve wound pain, while glycerin keeps the wound moist. At the same time, the film formed has good flexibility and will not affect the movement of joints and other parts, thus improving the user's comfort.

[0064] 5. Good stability: Citrate ions (C6H5O7) 3- ) Chelating Cu² +Subsequently, its positive charge is neutralized to ensure the system's uniformity and stability. A buffer system formed by sodium citrate and acetic acid precisely controls the pH, satisfying both the requirements for chitosan dissolution and film formation while maintaining antibacterial activity and skin safety. This ensures product stability, allowing for uniform mixing of all components and preventing layering or precipitation during storage and use.

[0065] Specifically, in this invention, the amount of sodium chloride added in step S1 is preferably 0.5-1.5 parts by weight, more preferably 0.8-1.2 parts; the amount of sodium citrate added is preferably 0.2-1.5 parts, more preferably 0.3-1.0 parts; the amount of copper gluconate added in step S2 is preferably 0.01-0.5 parts, more preferably 0.01-0.05 parts; the amount of L-menthol added in step S3 is preferably 0.1-2 parts, more preferably 0.5-1.5 parts; the amount of glycerol added is preferably 3-15 parts, more preferably 5-10 parts; the amount of Tween 20 added is preferably 0.4-3 parts, more preferably 0.5-2 parts; the amount of acetic acid added in step S5 is preferably 0.5-3 parts, more preferably 0.5-1.5 parts; and the amount of chitosan added is preferably 1-3 parts, more preferably 1-2 parts.

[0066] Another object of the present invention is to provide a liquid bandage, which is prepared by the liquid bandage preparation method described above.

[0067] The liquid wound dressing provided by this invention can quickly form a protective film on the wound surface, effectively inhibiting bacterial growth and promoting wound healing. It also has good flexibility and comfort, and is less irritating, thus solving the problems of weak antibacterial properties, strong irritation, and slow film formation of existing wound dressings.

[0068] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, specific embodiments of the present invention will be described in detail below.

[0069] Example 1

[0070] This embodiment provides a method for preparing a liquid wound dressing, including the following steps:

[0071] S1: According to the weight parts, add 1 part of sodium chloride and 0.5 parts of sodium citrate to 35 parts of pure water, and sonicate until completely dissolved to obtain mixture A;

[0072] S2: Slowly add 0.03 parts of copper gluconate to mixture A, and use sonication to fully disperse the copper gluconate in the solution to form mixture B;

[0073] S3: Mix 1.5 parts of Tween 20 with 8 parts of glycerin until homogeneous, add 1 part of L-menthol, and stir thoroughly to form mixture C;

[0074] S4: Slowly add mixture C to mixture B, and use ultrasound to fully mix the components to form mixture D;

[0075] S5: Add 1 part acetic acid to 50 parts pure water, mix well, then add 1.5 parts chitosan, and dissolve it by ultrasonication to obtain a chitosan-acetic acid solution.

[0076] S6: Slowly add the chitosan-acetic acid solution to mixture D, and use ultrasound to ensure that the chitosan is completely dissolved and evenly dispersed to form mixture E;

[0077] S7: Adjust the pH of mixture E to 5.5 by adding sodium citrate (or an appropriate amount of pure water if necessary), filter it through a filter to remove any possible impurities; fill the filtered solution into a suitable package, affix a label, and sterilize it by irradiation to obtain a liquid bandage.

[0078] Example 2

[0079] This embodiment provides a method for preparing a liquid wound dressing, including the following steps:

[0080] S1: According to the weight parts, add 0.8 parts of sodium chloride and 0.3 parts of sodium citrate to 41 parts of pure water, and sonicate until completely dissolved to obtain mixture A;

[0081] S2: Slowly add 0.01 parts of copper gluconate to mixture A, and use sonication to fully disperse the copper gluconate in the solution to form mixture B;

[0082] S3: Mix 0.5 parts of Tween 20 with 5 parts of glycerin until homogeneous, add 0.5 parts of L-menthol, and stir thoroughly to form mixture C;

[0083] S4: Slowly add mixture C to mixture B, and use ultrasound to fully mix the components to form mixture D;

[0084] S5: Add 0.5 parts of acetic acid to 50 parts of pure water, mix well, then add 1 part of chitosan, and dissolve it by ultrasonication to obtain a chitosan-acetic acid solution.

[0085] S6: Slowly add the chitosan-acetic acid solution to mixture D, and use ultrasound to ensure that the chitosan is completely dissolved and evenly dispersed to form mixture E;

[0086] S7: Adjust the pH of mixture E to 5.0 by adding acetic acid solution, filter it through a filter to remove any possible impurities; fill the filtered solution into suitable packaging, affix a label, and sterilize it by irradiation to obtain a liquid wound dressing.

[0087] Example 3

[0088] This embodiment provides a method for preparing a liquid wound dressing, including the following steps:

[0089] S1: According to the weight parts, add 1.2 parts of sodium chloride and 1 part of sodium citrate to 30 parts of pure water, and sonicate until completely dissolved to obtain mixture A;

[0090] S2: Slowly add 0.05 parts of copper gluconate to mixture A, and use sonication to fully disperse the copper gluconate in the solution to form mixture B;

[0091] S3: Mix 2 parts of Tween 20 and 10 parts of glycerin evenly, add 1.5 parts of L-menthol, and stir thoroughly to form mixture C;

[0092] S4: Slowly add mixture C to mixture B, and use ultrasound to fully mix the components to form mixture D;

[0093] S5: Add 1.5 parts of acetic acid to 50 parts of pure water, mix well, then add 2 parts of chitosan, and dissolve it by ultrasonication to obtain a chitosan-acetic acid solution.

[0094] S6: Slowly add the chitosan-acetic acid solution to mixture D, and use ultrasound to ensure that the chitosan is completely dissolved and evenly dispersed to form mixture E;

[0095] S7: Adjust the pH of mixture E to 5.8 by adding sodium citrate (or an appropriate amount of pure water if necessary), filter it through a filter to remove any possible impurities; fill the filtered solution into suitable packaging, affix a label, and sterilize it by irradiation to obtain a liquid bandage.

[0096] Comparative Example 1

[0097] This comparative example provides a method for preparing a liquid wound dressing, comprising the following steps:

[0098] S1: According to the weight parts, add 1 part of sodium chloride and 0.5 parts of sodium citrate to 35 parts of pure water, and sonicate until completely dissolved to obtain mixture A;

[0099] S2: Slowly add 0.03 parts of copper gluconate to mixture A, and use sonication to fully disperse the copper gluconate in the solution to form mixture B;

[0100] S3: Mix 1.5 parts of Tween 20 with 8 parts of glycerin until homogeneous, add 1 part of L-menthol, and stir thoroughly to form mixture C;

[0101] S4: Slowly add mixture C to mixture B, and use ultrasound to fully mix the components to form mixture D;

[0102] S5: Slowly add 1.5 parts of chitosan to mixture D, and use ultrasound to ensure that the chitosan is evenly dispersed to form mixture E;

[0103] S6: During the operation, it was found that most of the chitosan remained undissolved because acetic acid was not added beforehand. Furthermore, the solution pH was 6.3, higher than the target pH of 5.5. Even after adjusting the pH to 5.5 with acetic acid, some chitosan remained undissolved. The solution was then filtered to remove any impurities and undissolved chitosan. The filtered solution was then bottled, labeled, and sterilized by irradiation to obtain a liquid wound dressing.

[0104] Comparative Example 2

[0105] This comparative example provides a method for preparing a liquid wound dressing, comprising the following steps:

[0106] S1: According to the weight parts, add 1 part of sodium chloride and 0.5 parts of sodium citrate to 35 parts of pure water, and sonicate until completely dissolved to obtain mixture A;

[0107] S2: Mix 1.5 parts of Tween 20 with 8 parts of glycerin until homogeneous, add 1 part of L-menthol, and stir thoroughly to form mixture B;

[0108] S3: Slowly add mixture B to mixture A, and use ultrasound to fully mix the components to form mixture C;

[0109] S4: Add 1 part acetic acid to 50 parts pure water, mix well, then add 1.5 parts chitosan, and dissolve it by ultrasonication to obtain a chitosan-acetic acid solution.

[0110] S5: Slowly add the chitosan-acetic acid solution to mixture C, and use ultrasonic operation to ensure that the chitosan is completely dissolved and uniformly dispersed to form mixture D;

[0111] S6: Adjust the pH of mixture D to 5.5 by adding sodium citrate (and a suitable amount of pure water if necessary). Filter the solution through a filter to remove any impurities. Fill the filtered solution into suitable packaging, label it, and sterilize it by irradiation to obtain a liquid bandage.

[0112] Comparative Example 3

[0113] This comparative example provides a method for preparing a liquid wound dressing, comprising the following steps:

[0114] S1: Add 1.5 parts sodium chloride to 35 parts pure water by weight, and sonicate until completely dissolved to obtain mixture A;

[0115] S2: Slowly add 0.03 parts of copper gluconate to mixture A, and use sonication to fully disperse the copper gluconate in the solution to form mixture B;

[0116] S3: Mix 1.5 parts of Tween 20 with 8 parts of glycerin until homogeneous, add 1 part of L-menthol, and stir thoroughly to form mixture C;

[0117] S4: Slowly add mixture C to mixture B, and use ultrasound to fully mix the components to form mixture D;

[0118] S5: Add 1 part acetic acid to 50 parts pure water, mix well, then add 1.5 parts chitosan, and dissolve it by ultrasonication to obtain a chitosan-acetic acid solution.

[0119] S6: Slowly add the chitosan-acetic acid solution to mixture D, and use ultrasound to ensure that the chitosan is completely dissolved and evenly dispersed to form mixture E;

[0120] S7: During the operation, it was found that mixture E partially agglomerated because sodium citrate was not added first. The pH of mixture E was adjusted to 5.5 by adding sodium citrate (and a suitable amount of pure water if necessary), but the agglomerates were not completely dissolved. The solution was then filtered to remove any impurities and undissolved substances. The filtered solution was then bottled into suitable packaging, labeled, and sterilized by irradiation to obtain a liquid wound dressing.

[0121] Comparative Example 4:

[0122] This embodiment provides a method for preparing a liquid wound dressing, including the following steps:

[0123] S1: According to the weight parts, add 1 part of sodium chloride and 0.5 parts of sodium citrate to 35 parts of pure water, and sonicate until completely dissolved to obtain mixture A;

[0124] S2: Slowly add 0.03 parts of copper gluconate to mixture A, and use sonication to fully disperse the copper gluconate in the solution to form mixture B;

[0125] S3: Mix 1 part L-menthol with 8 parts glycerol and stir thoroughly to form mixture C;

[0126] S4: Slowly add mixture C to mixture B, and use ultrasound to fully mix the components to form mixture D;

[0127] S5: Add 1 part acetic acid to 50 parts pure water, mix well, then add 1.5 parts chitosan, and dissolve it by ultrasonication to obtain a chitosan-acetic acid solution.

[0128] S6: Slowly add the chitosan-acetic acid solution to mixture D, and use ultrasound to ensure that the chitosan is completely dissolved and evenly dispersed to form mixture E;

[0129] S7: Adjust the pH of mixture E to 5.5 by adding sodium citrate and replenish the remaining water. Filter the solution through a filter to remove any impurities; fill the filtered solution into suitable packaging, label it, and sterilize it by irradiation to obtain a liquid bandage.

[0130] The performance of the liquid wound dressings prepared in the above embodiments and comparative examples was tested using the following methods:

[0131] 1. Antibacterial performance test: The antibacterial performance of the liquid bandages in the above embodiments and comparative examples was tested according to GB / T 2591-2003, and the antibacterial rate was calculated.

[0132] 2. Product Stability: The liquid adhesive bandages of the above embodiments and comparative examples were subjected to accelerated aging verification tests according to YY / T 0681.1-2018. The sterilized products were placed in an aging chamber at a temperature of 40℃±2℃ and a humidity of 70%±5%, and the accelerated aging factor (AAF) was calculated as Q10.

（TAA-TRT） / 10

[0133] 3. Film forming speed: Take 5ml of the liquid bandage from each of the above examples and comparative examples, drop it onto the mold, and record the time from drop to complete film formation. Each sample is tested 5 times independently.

[0134] The test results are shown in Table 1:

[0135] Table 1

[0136] Antibacterial properties (bacterial reduction rate) stability Average film formation time Example 1 99.98% The sample remained unchanged throughout the entire aging validation cycle. 146s Example 2 99.15% The sample remained unchanged throughout the entire aging validation cycle. 201s Example 3 ＞99.99% At the last accelerated aging verification observation point (290 days), the sample color darkened. 123s Comparative Example 1 90.94% At the third accelerated aging validation observation point (64 days), the sample showed stratification and deterioration, with precipitates appearing. Unable to form a complete and uniform thin film Comparative Example 2 75.14% The sample remained unchanged throughout the entire aging validation cycle. 150s Comparative Example 3 89.25% At the second accelerated aging validation observation point (32 days), the sample showed stratification and deterioration, with precipitates appearing. 157s Comparative Example 4 99.96% At the sixth accelerated aging verification observation point (258 days), the sample showed stratification and deterioration, with precipitates appearing. 294s

[0137] As can be seen from the data in the table above, the liquid wound dressings prepared in each embodiment of the present invention all have excellent antibacterial properties, rapid film-forming properties, and stability.

[0138] The difference between Comparative Example 1 and Example 1 is that chitosan was added directly without pre-dissolving it in acetic acid. Because the solubility of chitosan is reduced, the undissolved chitosan was filtered out during the filtration process, which resulted in the liquid wound dressing failing to form a film and the system being unstable, causing the solution to deteriorate in a short period of time.

[0139] The difference between Comparative Example 2 and Example 1 is that copper gluconate was not added. Due to the lack of the synergistic antibacterial effect of copper gluconate, the antibacterial performance of the liquid wound dressing was reduced.

[0140] The difference between Comparative Example 3 and Example 1 is that sodium citrate was not added, because chitosan carries a positive charge (-NH4+) in acidic solutions. 3+ ), directly in contact with Cu 2+ Electrostatic adsorption and aggregation are prone to occur. Filtering out these aggregates during the filtration process reduces the antibacterial properties of the liquid bandage and makes the system unstable, resulting in the appearance of precipitates in a short period.

[0141] The difference between Comparative Example 4 and Example 1 is that Tween 20 was not added. As a result, the surface tension of water could not be reduced and the stability of the L-menthol dissolution system was reduced, which led to slow film formation and system instability of the liquid bandage.

[0142] Based on the above-described preferred embodiments of the present invention, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the inventive concept. The technical scope of this invention is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A method for preparing a liquid wound dressing, characterized in that, Includes the following steps: S1: Add sodium chloride and sodium citrate to water according to the formula, dissolve them, and obtain mixture A; S2: Add copper gluconate to mixture A to form mixture B; S3: Mix Tween 20 with glycerin, add L-menthol, and stir to form mixture C; S4: Add the mixture C to the mixture B to form mixture D; S5: Add acetic acid to water, mix well, then add chitosan and dissolve to obtain a chitosan-acetic acid solution; S6: Add the chitosan-acetic acid solution to the mixture D, dissolve, and form mixture E; S7: Adjust the pH of the mixture E to 4.5-6.5, filter, fill, sterilize, and obtain a liquid wound dressing; The amount of acetic acid added in step S5 is 0.5-3 parts by weight; the amount of chitosan added in step S5 is 1-3 parts.

2. The method for preparing the liquid bandage as described in claim 1, characterized in that, The amount of sodium chloride added in step S1 is 0.5-1.5 parts by weight.

3. The method for preparing the liquid bandage as described in claim 1, characterized in that, The amount of sodium citrate added in step S1 is 0.2-1.5 parts by weight.

4. The method for preparing the liquid bandage as described in claim 1, characterized in that, The amount of copper gluconate added in step S2 is 0.01-0.5 parts by weight.

5. The method for preparing the liquid bandage as described in claim 1, characterized in that, The amount of L-menthol added in step S3 is 0.1-2 parts by weight.

6. The method for preparing the liquid bandage as described in claim 1, characterized in that, The amount of glycerol added in step S3 is 3-15 parts by weight.

7. The method for preparing the liquid bandage as described in claim 1, characterized in that, The amount of Tween 20 added in step S3 is 0.4-3 parts by weight.

8. A liquid bandage, characterized in that, The liquid bandage is prepared by the method described in any one of claims 1-7.