Microsphere preparation device and preparation method

Abstract

The invention discloses a microsphere preparation device. The microsphere preparation device comprises a microsphere preparation module and a sorting module, the ball forming module comprises a storage bin, a firing pin and a power mechanism, a nozzle structure is arranged at the bottom of the storage bin, the firing pin is arranged in the storage bin and opposite to the nozzle structure, and the power mechanism is connected with the firing pin and used for driving the firing pin to move back and forth along the central axis of the firing pin; the sequencing module is provided with a liquid inlet channel and a sequencing channel, and the outlet end of the nozzle structure and the liquid inlet channel are both communicated with the sequencing channel; wherein the firing pin is matched with the nozzle structure and used for pressing materials in the storage bin chamber into blocks one by one and then pushing the blocks into the sequencing channel, and the blocks flow along with liquid in the sequencing channel and are shaped into microspheres. The invention further discloses a preparation method of the microspheres. According to the invention, the pelletizing problem of substances with high viscosity, easy wall hanging and easy dispersion is solved, and industrial production is realized.

Description

Technical Field

[0001] The present invention relates to the technical field of microsphere preparation, and particularly to a microsphere preparation device and a preparation method thereof. Background Art

[0002] For substances with high viscosity, easy to disperse, and easy to adhere to the wall, under normal circumstances, they cannot form spheres alone. Due to high viscosity, it is difficult to shear it by means of fluid shear, and it cannot be separated from the surrounding substances, so it cannot form a single sphere; and due to the characteristic of being easy to adhere to the surrounding substances (adhering to the wall), once local adhesion occurs between this substance and the surrounding substances, it will be adsorbed and cannot be separated; due to the above characteristics, when local adhesion occurs between two microspheres due to the close distance, they are very likely to fuse together, resulting in an increase in the size of the microspheres; traditional sphere-making processes cannot meet the requirements. For example, in the microfluidic droplet shearing method, due to high viscosity, shearing cannot be formed, and because this substance will adhere to the channel wall (i.e., the phenomenon of wall adhesion), the microfluidic method cannot effectively shear either.

[0003] Other sphere-making methods, such as spray drying method, polymerization method, self-curing method, interfacial polycondensation method, spray condensation method, air suspension method, porous centrifugation method, etc. Also, due to the high viscosity of the material, the characteristics of being easy to adhere to the surface of surrounding objects and easy to disperse, these methods cannot be realized.

[0004] When the three characteristics of high viscosity, easy to adhere to the wall, and easy to disperse are gathered in the same substance, it increases the difficulty of making spheres; but in reality, certain mixtures of drugs, sustained-release agents, daily necessities, and mixtures of cosmetics have these characteristics. In order to maintain the active ingredients of these products and facilitate long-term storage, it is necessary to make their active ingredients into microspheres and suspend them in a solution; to solve this problem, a microsphere preparation device and a preparation method are provided. Summary of the Invention

[0005] The purpose of the present invention is to provide a microsphere preparation device and a preparation method thereof to overcome the existing defects, solve the problem of making spheres for substances with high viscosity, easy to adhere to the wall, and easy to disperse, and realize industrial production.

[0006] The technical solution to achieve the above purpose is as follows: A microsphere preparation device of the present invention includes: a sphere-making module and a sorting module; The sphere-making module includes a storage bin chamber, a plunger, and a power mechanism. A nozzle structure is provided at the bottom of the storage bin chamber. The plunger is arranged in the storage bin chamber and is opposite to the position of the nozzle structure. The power mechanism is connected to the plunger and is used to drive the plunger to move back and forth along its central axis; The sorting module has an inlet channel and a sorting channel. The outlet end of the nozzle structure and the inlet channel are both communicated with the sorting channel; Wherein, the striker cooperates with the nozzle structure to press the materials in the storage bin chamber into lumps one by one and then push them into the sorting channel, and the lumps flow along with the liquid in the sorting channel and are formed into microspheres.

[0007] Preferably, it further includes at least one feed port, which is arranged on the side wall of the ball-making module and communicated with the storage bin chamber, and the raw materials for microsphere preparation enter the storage bin chamber through the feed port.

[0008] Preferably, a pressure device is arranged at the feed port, and the pressure device is used to provide a positive pressure to push the materials at the feed port into the storage bin chamber.

[0009] Preferably, it further includes a liquid inlet, which is arranged on the side wall of the sorting module and communicated with the liquid inlet channel.

[0010] Preferably, the liquid inlet channel includes a first flow channel and a second flow channel. The first channel extends in the same direction as the sorting channel, and the cross-section of the first flow channel is annular. One end of the first channel is communicated with the liquid inlet, the other end of the first channel is communicated with one end of the second flow channel, and the other end of the second flow channel is communicated with the sorting channel.

[0011] Preferably, the longitudinal section of the liquid inlet channel is an M-shaped structure, and the sorting channel is connected to the central position of the M-shaped structure.

[0012] Preferably, the longitudinal section of the liquid inlet channel is a C-shaped structure with an opening downward, and the sorting channel is connected to the central position of the C-shaped structure.

[0013] Preferably, the inner wall shape of the nozzle structure is adapted to the end shape of the striker. When the striker is in the initial position, the inner wall of the nozzle structure fits with the striker head of the striker to form a seal, and the sealing method is linear seal or surface seal.

[0014] Preferably, the nozzle opening of the nozzle structure is a tapered structure with a wider upper part and a narrower lower part. The taper angle range of the tapered structure is 0-60 degrees, and the height dimension range of the nozzle opening is 0.05mm-5mm.

[0015] Preferably, the nozzle opening, the sorting channel and the striker are coaxially arranged.

[0016] Preferably, it further includes: a control unit and a liquid delivery unit; The liquid delivery unit is communicated with the liquid inlet channel through a liquid inlet, and both the power mechanism and the liquid delivery unit are electrically connected to the control unit, which is used to control the liquid flow rate and the impact frequency and amplitude of the striker.

[0017] Preferably, a feeding unit is further included, which is used to continuously deliver raw materials for preparing microspheres to the storage bin chamber.

[0018] Preferably, a microsphere collection and detection unit is further included, which is connected to the outlet of the sorting channel and is used to collect and detect microsphere products.

[0019] Preferably, a pressure filling unit is further included, which is arranged downstream of the microsphere collection and detection device and is used to fill the qualified microsphere products.

[0020] Preferably, a waste liquid recovery unit is further included, which is arranged downstream of the microsphere collection and detection device and is used to recover waste liquid from unqualified microsphere products.

[0021] A method for preparing microspheres according to the second aspect of the present invention includes: Step S1: Continuously deliver raw materials for preparing microspheres to the feed inlet and control the pressure at the feed inlet. Step S2: Under the action of pressure, the raw materials for preparing microspheres enter and fill the storage bin chamber, and the pressure in the storage bin chamber is maintained. Step S3: Drive the striker to move up and down reciprocally through a power mechanism. When the striker moves upward, the raw materials for preparing microspheres in the storage bin chamber quickly fill the position vacated by the striker head under the action of pressure; when the striker quickly moves downward, the raw materials for preparing microspheres at the nozzle opening are pressed into a block, and the block is quickly pushed out of the nozzle opening and separated from the nozzle opening under the action of inertia and flows into the sorting channel. Step S4: Meanwhile, the liquid at the liquid inlet flows into the sorting channel through the liquid inlet channel, and the circumferential cutting force of the liquid causes the block to separate from the nozzle opening. Step S5: The block moves with the liquid towards the outlet of the sorting channel. During this process, the block gradually becomes a spherical sphere under the action of surface tension.

[0022] Preferably, it further includes: when the movement frequency of the striker is constant, adjusting the size of the microspheres by adjusting the pressure at the feed inlet. When the pressure at the feed inlet increases, the sphere becomes larger; conversely, when the pressure decreases, the sphere becomes smaller.

[0023] Preferably, it further includes: when the pressure at the feed inlet is constant, adjusting the ejection volume and ejection frequency of the lumps by adjusting the movement frequency of the striker; When the impact frequency of the striker increases, the ejection volume of the lumps becomes smaller and the ejection frequency becomes faster; conversely, the ejection volume of the lumps becomes larger and the ejection frequency becomes slower.

[0024] Preferably, it further includes: when the pressure at the feed inlet and the impact frequency of the striker are constant, adjusting the ejection volume of the lumps by adjusting the impact amplitude of the striker; When the impact amplitude of the striker increases, the ejection volume of the lumps becomes larger; conversely, the ejection volume of the lumps becomes smaller.

[0025] Preferably, it further includes: adjusting the distance between the lumps by adjusting the liquid flow rate at the liquid inlet, thereby adjusting the ball-liquid ratio during microsphere collection.

[0026] Preferably, the raw material for microsphere preparation is a loose material, which is composed of at least two substances without cementation or with weak cementation, and the loose material has a high viscosity.

[0027] The beneficial effects of the present invention are as follows: by setting a liquid inlet, a liquid inlet channel, and a sorting channel, the liquid inlet channel ensures that the discharged substance is carried in the center of the sorting channel, so that the ejected substance does not contact the wall surface of the sorting channel, ensuring no wall sticking; at the same time, by controlling the flow rate at the liquid inlet, it is ensured that the spheres are discharged at a certain rate, preventing sphere aggregation at the nozzle, enabling continuous production, solving the problem that substances with high viscosity are not easily formed into spheres, solving the problem of wall sticking of the formed spheres of substances prone to wall sticking, and also solving the problem of easy fusion between spheres. Description of the Drawings

[0028] Figure 1 is a schematic cross-sectional view of the microsphere preparation device according to Embodiment 1 of the present invention; Figure 2 is an enlarged cross-sectional view of the nozzle according to Embodiment 1 of the present invention; Figure 3 is an enlarged cross-sectional view of the nozzle orifice according to Embodiment 1 of the present invention; Figure 4 is a schematic cross-sectional view of the microsphere preparation device according to Embodiment 2 of the present invention; Figure 5 is an enlarged cross-sectional view of the nozzle according to Embodiment 2 of the present invention; Figure 6 is an enlarged cross-sectional view of the nozzle orifice according to Embodiment 2 of the present invention; Figure 7 is a flowchart of a microsphere preparation method according to the present invention.

[0029] In the figure: 1. Ball manufacturing module; 2. Sorting module; 11. Feed inlet; 12. Storage bin chamber; 13. Nozzle; 131. Inner wall; 132. Nozzle orifice; 14. Piston pin; 141. Piston pin head; 21. Liquid inlet; 22. Liquid inlet channel; 23. Sorting channel; 3. Mass. Detailed implementation manners

[0030] The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings. In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention. In addition, the terms "first", "second", and "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0031] The present invention will be further described below with reference to the accompanying drawings.

[0032] As Figures 1-6 shown, a microsphere preparation device includes: a ball manufacturing module 1 and a sorting module 2; The ball manufacturing module 1 includes a storage bin chamber 12, a piston pin 14 and a power mechanism. A nozzle structure 13 is provided at the bottom of the storage bin chamber 12. The piston pin 14 is disposed in the storage bin chamber 12 and is opposite to the position of the nozzle structure 13. The power mechanism is connected to the piston pin 14 and is used to drive the piston pin 14 to move back and forth along its central axis; The sorting module 2 has a liquid inlet channel 22 and a sorting channel 23. The outlet end of the nozzle structure 13 and the liquid inlet channel 22 are both communicated with the sorting channel 23; Wherein, the piston pin 14 cooperates with the nozzle structure 13 to press the materials in the storage bin chamber 12 into masses 3 one by one and then push them into the sorting channel 23. The masses 3 flow in the sorting channel 23 along with the liquid and are formed into microspheres.

[0033] In an embodiment, at least one feed inlet 11 is further included. The feed inlet 11 is provided on the side wall of the ball manufacturing module 1 and is communicated with the storage bin chamber 12. The raw materials for preparing microspheres enter the storage bin chamber 12 through the feed inlet 11.

[0034] In an embodiment, a pressure device is provided at the feed inlet 11. The pressure device is used to provide a positive pressure to push the materials at the feed inlet 11 into the storage bin chamber 12.

[0035] In the embodiment, it further includes a liquid inlet 21 which is arranged on the side wall of the sorting module 2 and communicated with the liquid inlet channel 22.

[0036] In the embodiment, the liquid inlet channel 22 includes a first flow channel and a second flow channel. The first channel extends in the same direction as the sorting channel 23, and the cross-section of the first flow channel is annular. One end of the first channel is communicated with the liquid inlet 21, the other end of the first channel is communicated with one end of the second flow channel, and the other end of the second flow channel is communicated with the sorting channel 23.

[0037] In the embodiment, the inner wall shape of the nozzle structure 13 is adapted to the end shape of the striker 14. When the striker 14 is in the initial position, the inner wall 131 of the nozzle structure 13 fits with the striker head 141 of the striker 14 to form a seal. The sealing method is linear sealing or surface sealing. When sealed, it is ensured that the raw material does not leak out, and only when it is ejected will it be an independent ball. Otherwise, the ejected substance is a continuous line.

[0038] In the embodiment, the nozzle orifice 132 of the nozzle structure 13 is a tapered structure with a wider upper part and a narrower lower part. The taper angle range of the tapered structure is 0 - 60 degrees, and the height dimension range of the nozzle orifice 132 is 0.05 mm - 5 mm.

[0039] In the embodiment, the nozzle orifice 132, the sorting channel 23 and the striker 14 are coaxially arranged.

[0040] In the embodiment, it further includes: a control unit and a liquid delivery unit; The liquid delivery unit is communicated with the liquid inlet channel 22 through the liquid inlet 21. Both the power mechanism and the liquid delivery unit are electrically connected to the control unit. The control unit is used to control the liquid flow rate, as well as the impact frequency and impact amplitude of the striker 14.

[0041] In the embodiment, it further includes a feeding unit which is used to continuously supply the raw materials for preparing microspheres to the storage bin chamber 12.

[0042] In the embodiment, it further includes a microsphere collection and detection unit which is connected to the outlet of the sorting channel 23 and is used to collect and detect microsphere products.

[0043] In the embodiment, it further includes a pressure filling unit which is arranged downstream of the microsphere collection and detection device and is used to fill the qualified microsphere products.

[0044] In the embodiment, it further includes a waste liquid recovery unit which is arranged downstream of the microsphere collection and detection device and is used to recover the waste liquid of the unqualified microsphere products.

[0045] In the embodiment, the feeding unit, the microsphere collection and detection unit, the pressure filling unit and the waste liquid recovery unit are all electrically connected to the control unit and are centrally controlled by the control unit.

[0046] Among them, the structure of the liquid inlet channel 22 can be set into two structural forms, and will be described in detail through the following two embodiments. Embodiment

[0047] As Figure 1 、 2 shown, the longitudinal section of the liquid inlet channel 22 is an M-shaped structure, the sorting channel 23 is connected to the central position of the M-shaped structure, both the sorting channel 23 and the first channel of the liquid inlet channel 22 are vertically arranged, one end of the second channel communicates with the top end of the first channel, and the other end is inclined downward and communicates with the top end of the sorting channel 23. Correspondingly, the outer wall of the nozzle structure 13 is an inclined surface.

[0048] After the liquid enters the liquid inlet channel 22 through the liquid inlet 21, it first flows in the outer annular channel, i.e., the first flow channel, and then enters the inner conical channel, i.e., the second flow channel, when reaching the highest point, and flows to the lowest point of the inner conical channel under the dual action of liquid pressure and gravity, and thus enters the sorting channel 23. Embodiment

[0049] As Figure 4 、 5 shown, the longitudinal section of the liquid inlet channel 22 is a C-shaped structure with an opening downward, the sorting channel 23 is connected to the central position of the C-shaped structure; the second channel of the liquid inlet channel 22 is horizontally arranged, one end of which communicates with the top end of the first channel, and the other end communicates with the top end of the sorting channel 23, that is, the top end of the first channel is flush with the top end of the sorting channel 23, and the outer wall of the nozzle structure 13 is a plane.

[0050] After the liquid enters the liquid inlet channel 22 through the liquid inlet 21, it first flows in the outer annular channel, i.e., the first flow channel, and then enters the inner plane channel when reaching the highest point, and flows to the sorting channel 23 under the action of liquid pressure.

[0051] The purpose of such a setting is to guide the flow of the liquid so that the liquid can generate a circumferential cutting force when reaching the outlet end of the nozzle structure 13, helping the block 3 at the outlet end to break away from the nozzle structure 13.

[0052] The microsphere preparation device provided by the present application can use a substance with a loose structure and easy to disperse as the microsphere preparation raw material. The loose substance is first impacted into blocks by the ball-making module 1, and then the circumferential cutting separation is realized by the liquid in the sorting module 2, and finally formed into balls in the liquid. Moreover, the microsphere preparation device has no limitation on the viscosity of the microsphere preparation raw material. Even for a loose substance with high viscosity, it can be successfully formed into balls without wall sticking problems.

[0053] As Figure 7 shown, a microsphere preparation method includes: Step S1, continuously convey the raw materials for microsphere preparation to the feed inlet 11 and control the pressure at the feed inlet 11.

[0054] In the embodiment, the raw materials for microsphere preparation are loose substances, the loose substances are composed of at least two substances without cementation or with weak cementation, and the loose substances have high viscosity. Preferably, the viscosity of the loose substances is between 50000 CP and 200000 CP. Further preferably, the viscosity of the loose substances is between 60000 CP and 100000 CP.

[0055] In the embodiment, the feed inlet 11 is connected to the raw material container; the raw material container is communicated with a pneumatic device, and the pneumatic device gives air pressure and conducts the pressure to the raw material container and the feed inlet 11 communicated with the raw material container.

[0056] Step S2, under the action of pressure, the raw materials for microsphere preparation enter and fill the storage bin chamber 12, and the pressure in the storage bin chamber 12 is maintained.

[0057] In the embodiment, the storage bin chamber 12 and the liquid inlet 21, including the raw material container communicated with the liquid inlet 21, are all airtight. Apply air pressure inside the raw material container, and the air pressure can be conducted to the entire passage.

[0058] Step S3, drive the striker 14 to move up and down reciprocally through a power mechanism.

[0059] In the embodiment, when the striker 14 moves upward, the raw materials for microsphere preparation in the storage bin chamber 12 quickly fill the position vacated by the striker head 141 under the action of pressure; when the striker 14 quickly moves downward, the raw materials for microsphere preparation located at the nozzle orifice 132 are pressed into a block 3, and the block 3 is quickly pushed out of the nozzle orifice 132 and separated from the nozzle orifice 132 under the action of inertia and flows into the sorting channel 23.

[0060] Step S4, meanwhile, the liquid at the liquid inlet 21 flows into the sorting channel 23 through the liquid inlet channel 22, and the circumferential cutting force of the liquid prompts the block 3 to separate from the nozzle orifice 132.

[0061] Step S5, the block 3 moves towards the outlet of the sorting channel 23 along with the liquid. During this process, the block 3 gradually becomes a spherical sphere under the action of surface tension.

[0062] In the embodiment, the firing pin 14 continuously and rapidly impacts the inner cavity of the nozzle. Each time it impacts, the head of the firing pin will contact the inner wall of the nozzle and seal the nozzle orifice 132. Moreover, a positive pressure is always maintained in the storage bin chamber 12. Even when a certain negative pressure is generated at the nozzle orifice 132 when the firing pin 14 is lifted, the material in the bin will quickly fill the position vacated by the head of the firing pin under the action of the pressure. Therefore, the nozzle orifice 132 will not suck in too much liquid flow or air due to the negative pressure, and these liquid flows or air will not affect the microsphere preparation. By using the microsphere preparation device provided in this application, as long as the impact frequency of the firing pin 14, the pressure of the material in the bin, and the pressure of the liquid flow outside the bin are controlled, stable high-viscosity phase droplet microspheres can be formed.

[0063] In the embodiment, when the frequency of the firing pin 14 is fixed, by adjusting the pressure at the feed inlet 11, the size of the microspheres can be adjusted. When the pressure at the feed inlet 11 is increased, the sphere becomes larger; conversely, the sphere becomes smaller.

[0064] In the embodiment, when the pressure at the feed inlet 11 is fixed, by adjusting the frequency of the firing pin 14, the ejection volume and ejection frequency of the block 3 can be adjusted. When the frequency of the firing pin 14 is increased, the ejection volume of the block 3 becomes smaller and the ejection frequency becomes faster; conversely, the ejection volume of the block 3 becomes larger and the ejection frequency becomes slower.

[0065] In the embodiment, when the pressure at the feed inlet 11 and the frequency of the firing pin 14 are fixed, by adjusting the amplitude of the up-and-down movement of the firing pin 14, the ejection volume of the block 3 can be adjusted. When the amplitude of the up-and-down movement of the firing pin 14 is increased, the ejection volume of the block 3 becomes larger; conversely, the ejection volume of the block 3 becomes smaller.

[0066] In the embodiment, by adjusting the flow rate of the liquid at the liquid inlet 21, the distance between the blocks 3 can be adjusted so as not to cause fusion due to the proximity of the substances, and then the proportion of the spherical liquid in the spherical liquid collected at the outlet can be adjusted. For some substances that need to be formulated and bottled or stored in a certain proportion (such as cosmetic microspheres, drug suspensions), through this method, secondary proportioning is not required, avoiding adverse effects such as microspheres sticking to the wall, breaking, and fusing caused by excessive operations.

[0067] Through the comprehensive implementation and reasonable configuration of the above variables, the ejection volume, ejection frequency, and the interval distance between substances can be adjusted, so as to produce spheres of different sizes, change the production efficiency, and adjust the sphere-liquid ratio.

[0068] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A microsphere preparation device, characterized in that, Comprising: A ball manufacturing module (1) and a sorting module (2); The ball manufacturing module (1) includes a storage bin chamber (12), a plunger (14), and a power mechanism. A nozzle structure (13) is provided at the bottom of the storage bin chamber (12). The plunger (14) is disposed in the storage bin chamber (12) and is opposite to the position of the nozzle structure (13). The power mechanism is connected to the plunger (14) and is used to drive the plunger (14) to move back and forth along its central axis; The sorting module (2) has a liquid inlet channel (22) and a sorting channel (23). The outlet end of the nozzle structure (13) and the liquid inlet channel (22) are both communicated with the sorting channel (23); Wherein, the plunger (14) cooperates with the nozzle structure (13) to press the materials in the storage bin chamber (12) into lumps (3) one by one and then push them into the sorting channel (23). The lumps (3) flow in the sorting channel (23) along with the liquid and are formed into microspheres.

2. The microsphere preparation device according to claim 1, characterized in that, It further includes at least one feed inlet (11). The feed inlet (11) is provided on the side wall of the ball manufacturing module (1) and is communicated with the storage bin chamber (12). The raw materials for microsphere preparation enter the storage bin chamber (12) through the feed inlet (11).

3. The microsphere preparation device according to claim 2, characterized in that, A pressure device is provided at the feed inlet (11). The pressure device is used to provide a positive pressure to push the materials at the feed inlet (11) into the storage bin chamber (12).

4. The microsphere preparation device according to claim 1, characterized in that, It further includes a liquid inlet (21). The liquid inlet (21) is provided on the side wall of the sorting module (2) and is communicated with the liquid inlet channel (22).

5. The microsphere preparation device according to claim 4, characterized in that, The liquid inlet channel (22) includes a first flow channel and a second flow channel. The first channel extends in the same direction as the sorting channel (23), and the cross-section of the first flow channel is annular. One end of the first channel is communicated with the liquid inlet (21), the other end of the first channel is communicated with one end of the second flow channel, and the other end of the second flow channel is communicated with the sorting channel (23).

6. The microsphere preparation device according to claim 5, characterized in that, The longitudinal section of the liquid inlet channel (22) is an M-shaped structure, and the sorting channel (23) is connected to the central position of the M-shaped structure.

7. The microsphere preparation device according to claim 5, characterized in that, The longitudinal section of the liquid inlet channel (22) is a C-shaped structure with an opening downward, and the sorting channel (23) is connected to the central position of the C-shaped structure.

8. The microsphere preparation device according to claim 1, characterized in that, The inner wall shape of the nozzle structure (13) is adapted to the end shape of the plunger (14). When the plunger (14) is in the initial position, the inner wall (131) of the nozzle structure (13) fits with the plunger head (141) of the plunger (14) to form a seal, and the sealing method is linear sealing or surface sealing.

9. The microsphere preparation device according to claim 1, characterized in that, The nozzle orifice (132) of the nozzle structure (13) is a tapered structure with a wider upper part and a narrower lower part. The taper angle range of the tapered structure is 0-60 degrees, and the height dimension range of the nozzle orifice (132) is 0.05 mm - 5 mm.

10. The microsphere preparation device according to claim 9, characterized in that, The nozzle orifice (132), the sorting channel (23), and the plunger (14) are coaxially arranged.

11. The microsphere preparation device according to claim 1, characterized in that, It further includes: A control unit and a liquid delivery unit; The liquid delivery unit is communicated with the liquid inlet channel (22) through a liquid inlet (21). Both the power mechanism and the liquid delivery unit are electrically connected to the control unit, and the control unit is used to control the liquid flow rate, as well as the impact frequency and impact amplitude of the striker (14).

12. The microsphere preparation device according to claim 1, characterized in that, It further includes a feeding unit, which is used to continuously supply raw materials for preparing microspheres to the storage bin chamber (12).

13. The microsphere preparation device according to claim 1, characterized in that, It further includes a microsphere collection and detection unit, which is connected to the outlet of the sorting channel (23) and is used to collect microsphere products and conduct detections.

14. The microsphere preparation device according to claim 13, characterized in that, It further includes a pressure filling unit, which is arranged downstream of the microsphere collection and detection device and is used to fill the qualified microsphere products.

15. The microsphere preparation device according to claim 13, characterized in that, It further includes a waste liquid recovery unit, which is arranged downstream of the microsphere collection and detection device and is used to recover the waste liquid of the unqualified microsphere products.

16. A microsphere preparation method, characterized in that, It includes: Step S1: Continuously convey the raw materials for preparing microspheres to the feed inlet (11) and control the pressure of the feed inlet (11). Step S2: Under the action of pressure, the raw materials for preparing microspheres enter and fill the storage bin chamber (12), and the pressure in the storage bin chamber (12) is maintained. Step S3: Drive the striker (14) to move up and down reciprocally through a power mechanism. When the striker (14) moves upward, the raw materials for preparing microspheres in the storage bin chamber (12) quickly fill the position vacated by the striker head (141) under the action of pressure. When the striker (14) quickly moves downward, the raw materials for preparing microspheres located at the nozzle orifice (132) are pressed into a block (3), and the block (3) is quickly pushed out of the nozzle orifice (132) and separated from the nozzle orifice (132) under the action of inertia and flows into the sorting channel (23). Step S4: Meanwhile, the liquid at the liquid inlet (21) flows into the sorting channel (23) through the liquid inlet channel (22), and the circumferential cutting force of the liquid causes the block (3) to separate from the nozzle orifice (132). Step S5: The block (3) moves towards the outlet of the sorting channel (23) along with the liquid. During this process, the block (3) gradually becomes a spherical shape under the action of surface tension.

17. The method for preparing microspheres according to claim 16, wherein, It further includes: When the movement frequency of the striker (14) is constant, adjust the pressure of the feed inlet (11) to adjust the size of the microspheres. When the pressure of the feed inlet (11) increases, the sphere becomes larger; conversely, the sphere becomes smaller.

18. The method for preparing microspheres according to claim 16, wherein, It further includes: When the pressure of the feed inlet (11) is constant, adjust the movement frequency of the striker (14) to adjust the ejection volume and ejection frequency of the block (3). When the impact frequency of the striker (14) increases, the ejection volume of the block (3) becomes smaller and the ejection frequency becomes faster; conversely, the ejection volume of the block (3) becomes larger and the ejection frequency becomes slower.

19. The method for preparing microspheres according to claim 16, wherein, It further includes: When the pressure of the feed inlet (11) and the impact frequency of the striker (14) are constant, adjust the impact amplitude of the striker (14) to adjust the ejection volume of the block (3). When the impact amplitude of the striker (14) increases, the ejection volume of the mass (3) is larger; conversely, the ejection volume of the mass (3) is smaller.

20. The method for preparing microspheres according to claim 16, wherein, It further includes: By adjusting the liquid flow rate of the liquid inlet (21), the distance between the masses (3) is adjusted, and thus the ball-liquid ratio during microsphere collection is adjusted.

21. The method for preparing microspheres according to claim 16, wherein, The raw material for preparing the microspheres is a loose material, the loose material is composed of at least two substances without cementation or with weak cementation, and the loose material has a high viscosity.

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