Microsphere preparation device and preparation method

Abstract

The present invention discloses a microsphere preparation device, comprising: a ball making module and a sorting module; the ball making module comprises a storage chamber, a striker and a power mechanism, a nozzle structure is provided at the bottom of the storage chamber, the striker is provided in the storage chamber and is opposite to the position of the nozzle structure, the power mechanism is connected to the striker, and is used to drive the striker to move back and forth along its central axis; the sorting module has a liquid inlet channel and a sorting channel, and the outlet end of the nozzle structure and the liquid inlet channel are both connected to the sorting channel; wherein the striker cooperates with the nozzle structure to press the materials in the storage chamber into blocks one by one and then push them into the sorting channel, and the blocks flow with the liquid in the sorting channel and are shaped into microspheres. A method for preparing microspheres is also disclosed. The present invention solves the problem of making balls of materials with high viscosity, easy to stick to the wall, and easy to disperse, and realizes industrial production.

Description

Technical Field

[0001] The present invention relates to the technical field of microsphere preparation, and in particular to a microsphere preparation device and method. Background Art

[0002] For materials with high viscosity, easy to disperse and easy to stick to the wall, under normal circumstances, they cannot be formed into balls alone.

[0003] Due to its high viscosity, it is difficult to cut it apart by fluid shearing, and it cannot be separated from the surrounding substances and cannot form a separate sphere; and it is easy to adhere to the surrounding substances (hanging on the wall). Once the substance is locally adhered to the surrounding substances, it will be adsorbed and cannot be separated; Due to the above characteristics, when the distance between two microspheres is close, once local adhesion occurs, they will easily fuse together, making the microsphere size larger; traditional ball making processes cannot meet this requirement, such as the microfluidic droplet shear method. Due to its high viscosity, shear cannot be formed. Since the substance will adhere to the channel wall (that is, hanging on the wall phenomenon), the microfluidic method cannot effectively shear.

[0004] Other ball-making methods, such as spray drying, polymerization, self-solidification, interfacial polycondensation, spray coagulation, air suspension, porous centrifugation, etc., cannot be achieved due to the high viscosity of the material and its easy adhesion to the surrounding surface and easy dispersion.

[0005] When high viscosity, easy adhesion to the wall, and easy dispersion are combined in the same substance, the difficulty of making microspheres increases. However, in reality, some mixtures of medicines, sustained-release agents, daily necessities, and cosmetics have these characteristics. In order to maintain the effective ingredients of these products and facilitate long-term storage, their effective ingredients need to be made into microspheres and suspended in a solution. To solve this problem, a microsphere preparation device and preparation method are provided. Summary of the Invention

[0006] The purpose of the present invention is to overcome the existing defects and provide a microsphere preparation device and preparation method, which solves the problem of making microspheres of high viscosity, easy to stick to the wall, and easy to disperse materials, and realizes industrial production.

[0007] The technical solution to achieve the above purpose is:

[0008] A microsphere preparation device according to one embodiment of the present invention comprises: a microsphere making module and a sorting module;

[0009] The ball making module includes a material storage chamber, a striker and a power mechanism. A nozzle structure is provided at the bottom of the material storage chamber. The striker is provided in the material storage chamber and is opposite to the nozzle structure. The power mechanism is connected to the striker and is used to drive the striker to move back and forth along its central axis.

[0010] The sorting module has a liquid inlet channel and a sorting channel, and the outlet end of the nozzle structure and the liquid inlet channel are both connected to the sorting channel;

[0011] Wherein, the striker cooperates with the nozzle structure to press the materials in the storage bin chamber into lumps one by one and then push them into the sorting channel, and the lumps flow along with the liquid in the sorting channel and are formed into microspheres.

[0012] Preferably, it further includes at least one feed inlet, and the feed inlet is arranged on the side wall of the ball-making module and is connected to the storage bin chamber, and the raw materials for preparing microspheres enter the storage bin chamber through the feed inlet.

[0013] Preferably, a pressure device is arranged at the feed inlet, and the pressure device is used to provide a positive pressure to push the materials at the feed inlet into the storage bin chamber.

[0014] Preferably, it further includes a liquid inlet, and the liquid inlet is arranged on the side wall of the sorting module and is connected to the liquid inlet channel.

[0015] Preferably, the liquid inlet channel includes a first channel and a second channel. The first channel extends in the same direction as the sorting channel, and the cross-section of the first channel is annular. One end of the first channel is connected to the liquid inlet, the other end of the first channel is connected to one end of the second channel, and the other end of the second channel is connected to the sorting channel.

[0016] Preferably, the longitudinal section of the liquid inlet channel is an M-shaped structure, and the sorting channel is connected to the central position of the M-shaped structure.

[0017] Preferably, the longitudinal section of the liquid inlet channel is a U-shaped structure with an opening downward, and the sorting channel is connected to the central position of the U-shaped structure.

[0018] Preferably, the inner wall shape of the nozzle structure is adapted to the end shape of the striker. When the striker is in the initial position, the inner wall of the nozzle structure fits with the striker head of the striker to form a seal, and the sealing method is linear sealing or surface sealing.

[0019] Preferably, the nozzle opening of the nozzle structure is a tapered structure with a wider upper part and a narrower lower part. The taper angle range of the tapered structure is 0-60 degrees, and the height dimension range of the nozzle opening is 0.05 mm-5 mm.

[0020] Preferably, the nozzle opening, the sorting channel and the striker are coaxially arranged.

[0021] Preferably, it further includes: a control unit and a liquid delivery unit;

[0022] The liquid delivery unit is communicated with the liquid inlet channel through a liquid inlet. The power mechanism and the liquid delivery unit are both electrically connected to the control unit. The control unit is used to control the liquid flow rate and the impact frequency and impact amplitude of the striker.

[0023] Preferably, it further comprises a feeding unit, which is used to continuously deliver raw materials for preparing microspheres to the storage chamber.

[0024] Preferably, a microsphere collection and detection unit is further included, which is connected to the outlet of the sorting channel and is used to collect microsphere products and perform detection.

[0025] Preferably, it further comprises a pressure filling unit, which is arranged downstream of the microsphere collecting and detecting unit and is used to fill the microsphere products that have passed the test.

[0026] Preferably, the system further comprises a waste liquid recovery unit, which is arranged downstream of the microsphere collection and detection unit and is used to recover waste liquid from microsphere products that fail the test.

[0027] A second method for preparing microspheres according to the present invention comprises:

[0028] Step S1, continuously delivering the microsphere preparation raw materials to the feed port and controlling the pressure of the feed port;

[0029] Step S2, under the action of pressure, the raw materials for preparing microspheres enter and fill the storage chamber, and the pressure in the storage chamber is maintained;

[0030] Step S3, driving the striker to reciprocate up and down through the power mechanism;

[0031] When the striker moves upward, the raw materials for microsphere preparation in the storage chamber quickly fill the space vacated by the striker head under the action of pressure; when the striker is quickly pressed downward, the raw materials for microsphere preparation at the nozzle opening are pressed into a block, which is quickly pushed out of the nozzle opening and, under the action of inertia, leaves the nozzle opening and flows into the sorting channel;

[0032] Step S4, at the same time, the liquid in the liquid inlet flows into the sorting channel through the liquid inlet channel, and the shear force of the liquid causes the block to separate from the nozzle opening;

[0033] In step S5, the block moves toward the outlet of the sorting channel along with the liquid. During this process, the block gradually changes into a round sphere under the action of surface tension.

[0034] Preferably, the method further comprises: adjusting the size of the microspheres by adjusting the pressure of the feed port when the striker movement frequency is constant;

[0035] When the pressure at the feed port increases, the sphere becomes larger, and vice versa.

[0036] Preferably, the method further comprises: adjusting the ejection volume and ejection frequency of the block by adjusting the movement frequency of the striker under a condition where the pressure of the feed port is constant;

[0037] When the impact frequency of the striker increases, the ejection volume of the block becomes smaller and the ejection frequency becomes faster; conversely, the ejection volume of the block becomes larger and the ejection frequency becomes slower.

[0038] Preferably, the method further comprises: adjusting the ejection volume of the block by adjusting the impact amplitude of the striker when the pressure of the feed port and the impact frequency of the striker are constant;

[0039] When the impact amplitude of the striker increases, the ejection volume of the block becomes larger; otherwise, the ejection volume of the block becomes smaller.

[0040] Preferably, the method further comprises: adjusting the distance between the blocks by adjusting the liquid flow rate of the liquid inlet, thereby adjusting the ball-liquid ratio during microsphere collection.

[0041] Preferably, the raw material for preparing the microspheres is a loose substance, which is composed of at least two non-cemented or weakly-cemented substances, and has high viscosity.

[0042] The beneficial effects of the present invention are as follows: by setting a liquid inlet, a liquid inlet channel and a sorting channel, the present invention ensures that the material coming out of the liquid inlet channel is wrapped in the center of the sorting channel, so that the ejected material does not contact the wall of the sorting channel and does not stick to the wall; at the same time, by controlling the flow rate of the liquid inlet, it is ensured that the spheres are discharged at a certain rate, so that the spheres do not gather at the nozzle, and the production is continuous, which solves the problem that high-viscosity materials are difficult to form into balls, and also solves the problem that materials that are easy to stick to the wall stick to the wall after forming balls. At the same time, it also solves the problem that the balls are easy to merge. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 1 is a cross-sectional schematic diagram of a microsphere preparation device according to Example 1 of the present invention;

[0044] Figure 2 is an enlarged cross-sectional view of the nozzle of Example 1 of the present invention;

[0045] Figure 3 is an enlarged cross-sectional view of the nozzle opening of Example 1 of the present invention;

[0046] Figure 4 is a cross-sectional schematic diagram of a microsphere preparation device according to a second embodiment of the present invention;

[0047] Figure 5 is an enlarged cross-sectional view of the nozzle of Example 2 of the present invention;

[0048] Figure 6 is an enlarged cross-sectional view of the nozzle opening of Example 2 of the present invention;

[0049] Figure 7 The present invention is a flow chart of a method for preparing microspheres.

[0050] In the figure: 1. Ball making module; 2. Sorting module; 11. Feed inlet; 12. Storage chamber; 13. Nozzle structure; 131. Inner wall; 132. Nozzle opening; 14. Strike pin; 141. Strike pin head; 21. Liquid inlet; 22. Liquid inlet channel; 23. Sorting channel; 3. Blocks. DETAILED DESCRIPTION

[0051] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. In the description of the present invention, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0052] The present invention will be further described below with reference to the accompanying drawings.

[0053] like Figure 1-6 A microsphere preparation device is shown, comprising: a microsphere making module 1 and a sorting module 2;

[0054] The ball making module 1 includes a material storage chamber 12, a striker 14, and a power mechanism. A nozzle structure 13 is provided at the bottom of the material storage chamber 12. The striker 14 is provided in the material storage chamber 12 and is located opposite to the nozzle structure 13. The power mechanism is connected to the striker 14 and is used to drive the striker 14 to move back and forth along its central axis.

[0055] The sorting module 2 has a liquid inlet channel 22 and a sorting channel 23. The outlet end of the nozzle structure 13 and the liquid inlet channel 22 are both connected to the sorting channel 23.

[0056] The striker 14 cooperates with the nozzle structure 13 to press the materials in the storage chamber 12 into blocks 3 one by one and then push them into the sorting channel 23. The blocks 3 flow with the liquid in the sorting channel 23 and are shaped into microspheres.

[0057] In the embodiment, at least one feed port 11 is further included. The feed port 11 is provided on the side wall of the pelletizing module 1 and communicates with the storage chamber 12 . Raw materials for preparing microspheres enter the storage chamber 12 through the feed port 11 .

[0058] In the embodiment, a pressure device is provided at the feed port 11 , and the pressure device is used to provide positive pressure to push the material at the feed port 11 into the storage chamber 12 .

[0059] In the embodiment, a liquid inlet 21 is further included. The liquid inlet 21 is disposed on a side wall of the sorting module 2 and communicates with the liquid inlet channel 22 .

[0060] In the embodiment, the liquid inlet channel 22 includes a first channel and a second channel, the first channel extends in the same direction as the sorting channel 23, and the cross-section of the first channel is annular, one end of the first channel is connected to the liquid inlet 21, the other end of the first channel is connected to one end of the second channel, and the other end of the second channel is connected to the sorting channel 23.

[0061] In the embodiment, the inner wall shape of the nozzle structure 13 is adapted to the end shape of the striker 14. When the striker 14 is in the initial position, the inner wall 131 of the nozzle structure 13 and the striker head 141 of the striker 14 fit together to form a seal. The sealing method is linear sealing or surface sealing. When sealing, it is ensured that the raw material does not leak out, and it will be independent balls when sprayed out. Otherwise, the sprayed material will be a continuous line.

[0062] In the embodiment, the nozzle opening 132 of the nozzle structure 13 is a tapered structure that is wide at the top and narrow at the bottom. The taper angle of the tapered structure ranges from 0 to 60 degrees, and the height of the nozzle opening 132 ranges from 0.05 mm to 5 mm.

[0063] In the embodiment, the nozzle opening 132 , the sorting channel 23 and the striker 14 are coaxially arranged.

[0064] In the embodiment, it further comprises: a control unit and a liquid delivery unit;

[0065] The liquid delivery unit is connected to the liquid inlet channel 22 through the liquid inlet 21 . The power mechanism and the liquid delivery unit are both electrically connected to a control unit. The control unit is used to control the liquid flow rate and the impact frequency and impact amplitude of the striker 14 .

[0066] In the embodiment, a feeding unit is further included, and the feeding unit is used to continuously deliver raw materials for preparing microspheres to the storage chamber 12 .

[0067] In the embodiment, it further includes a microsphere collection and detection unit, which is connected to the outlet of the sorting channel 23 and is used to collect and detect microsphere products.

[0068] In the embodiment, it further includes a pressure filling unit, which is arranged downstream of the microsphere collection and detection unit and is used to fill the qualified microsphere products detected.

[0069] In the embodiment, it further includes a waste liquid recovery unit, which is arranged downstream of the microsphere collection and detection unit and is used to recover the waste liquid of the unqualified microsphere products detected.

[0070] In the embodiment, the feeding unit, the microsphere collection and detection unit, the pressure filling unit and the waste liquid recovery unit are all electrically connected to the control unit and are centrally controlled by the control unit.

[0071] Among them, the structure of the liquid inlet channel 22 can be set into two structural forms, and will be described in detail through the following two embodiments.

[0072] Embodiment 1:

[0073] As Figure 1 , 2 shown, the longitudinal section of the liquid inlet channel 22 is an M-shaped structure, the sorting channel 23 is connected to the central position of the M-shaped structure, both the sorting channel 23 and the first channel of the liquid inlet channel 22 are arranged vertically, one end of the second channel is connected to the top of the first channel, and the other end is inclined downward and connected to the top of the sorting channel 23. Correspondingly, the outer wall of the nozzle structure 13 is a slope.

[0074] After the liquid enters the liquid inlet channel 22 through the liquid inlet 21, it first flows in the outer annular channel, that is, the first channel, and then enters the inner conical channel, that is, the second channel, after reaching the highest point, and flows to the lowest point of the inner conical channel under the dual action of liquid pressure and gravity, and thus enters the sorting channel 23.

[0075] Embodiment 2:

[0076] As Figure 4 , 5 shown, the longitudinal section of the liquid inlet channel 22 is a C-shaped structure with an opening downward, the sorting channel 23 is connected to the central position of the C-shaped structure; the second channel of the liquid inlet channel 22 is arranged horizontally, one end of which is connected to the top of the first channel, and the other end is connected to the top of the sorting channel 23, that is, the top of the first channel is flush with the top of the sorting channel 23, and the outer wall of the nozzle structure 13 is a plane.

[0077] After the liquid enters the liquid inlet channel 22 through the liquid inlet 21 , it first flows in the outer annular channel, i.e., the first channel, and then enters the inner planar channel after reaching the highest point, and flows to the sorting channel 23 under the action of liquid pressure.

[0078] The purpose of such a setting is to guide the flow of the liquid so that the liquid can generate a shear force when it reaches the outlet end of the nozzle structure 13, thereby helping the block 3 at the outlet end to separate from the nozzle structure 13.

[0079] The microsphere preparation device provided herein can use loose, easily dispersed materials as microsphere preparation raw materials. The loose materials are first impacted into agglomerates by ball-forming module 1, then separated by circular cutting using the liquid in sorting module 2, and finally shaped into balls in the liquid. Furthermore, the microsphere preparation device has no restrictions on the viscosity of the microsphere preparation raw materials; even high-viscosity loose materials can be smoothly formed into balls without the problem of sticking to the wall.

[0080] like Figure 7 As shown, a method for preparing microspheres comprises:

[0081] In step S1 , the raw materials for preparing microspheres are continuously delivered to the feed port 11 , and the pressure of the feed port 11 is controlled.

[0082] In the embodiment, the raw material for preparing the microspheres is a loose material, which is composed of at least two non-cemented or weakly bonded materials and has a high viscosity. Preferably, the viscosity of the loose material is between 50,000 cp and 200,000 cp. Furthermore, the viscosity of the loose material is between 60,000 cp and 100,000 cp.

[0083] In the embodiment, the feed port 11 is connected to the raw material container; the raw material container is connected to the air pressure device, and the air pressure device sets the air pressure and transmits the pressure to the raw material container and the feed port 11 connected to the raw material container.

[0084] In step S2 , under the action of pressure, the raw materials for preparing microspheres enter and fill the storage chamber 12 , and the pressure in the storage chamber 12 is maintained.

[0085] In the embodiment, the material storage chamber 12 and the liquid inlet 21, including the raw material container connected to the liquid inlet 21, are all sealed, and air pressure is applied to the interior of the raw material container, and the air pressure can be transmitted to the entire passage.

[0086] In step S3, the striker 14 is driven by the power mechanism to perform up and down reciprocating motion.

[0087] In the embodiment, when the striker 14 moves upward, the raw materials for preparing microspheres in the storage chamber 12 quickly fill the space vacated by the striker head 141 under the action of pressure; when the striker 14 is quickly pressed down, the raw materials for preparing microspheres located at the nozzle opening 132 are pressed into a block 3, which is quickly pushed out of the nozzle opening 132 and separated from the nozzle opening 132 under the action of inertia and merged into the sorting channel 23.

[0088] In step S4 , at the same time, the liquid in the liquid inlet 21 flows into the sorting channel 23 through the liquid inlet channel 22 , and the shear force of the liquid causes the block 3 to separate from the nozzle opening 132 .

[0089] In step S5 , the block 3 moves toward the outlet of the sorting channel 23 along with the liquid. During this process, the block 3 gradually changes into a round sphere under the action of surface tension.

[0090] In the embodiment, when the frequency of the striker 14 is constant, the size of the microspheres is adjusted by adjusting the pressure of the feed port 11. When the pressure of the feed port 11 increases, the size of the microspheres increases, and vice versa.

[0091] In the embodiment, when the pressure of the feed port 11 is constant, the ejection volume and ejection frequency of the block 3 are adjusted by adjusting the frequency of the striker 14. When the frequency of the striker 14 is increased, the ejection volume of the block 3 becomes smaller and the ejection frequency becomes faster. Conversely, the ejection volume of the block 3 becomes larger and the ejection frequency becomes slower.

[0092] In the embodiment, when the pressure of the feed port 11 and the frequency of the striker 14 are constant, the ejection volume of the block 3 is adjusted by adjusting the amplitude of the up and down movement of the striker 14. When the amplitude of the up and down movement of the striker 14 increases, the ejection volume of the block 3 becomes larger, and vice versa, the ejection volume of the block 3 becomes smaller.

[0093] In the embodiment, by adjusting the flow rate of the liquid at the liquid inlet 21 and the distance between the blocks 3, fusion due to the close proximity of the materials is prevented, and the ball-to-liquid ratio in the spherical melt collected at the outlet is adjusted. Certain materials that need to be mixed in a certain ratio for bottling or storage (such as cosmetic microspheres and drug suspensions) do not need to be mixed in a secondary ratio through this method, thus avoiding excessive operations that may cause the microspheres to stick to the wall, break, or fuse.

[0094] The combined implementation and reasonable configuration of the above variables can adjust the ejection volume, ejection frequency, and spacing between substances, thereby producing spheres of different sizes, changing production efficiency, and adjusting the ball-liquid ratio.

[0095] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A microsphere preparation device, characterized in that: Including: A ball manufacturing module (1) and a sorting module (2); The ball manufacturing module (1) includes a storage bin chamber (12), a striker (14) and a power mechanism. A nozzle structure (13) is provided at the bottom of the storage bin chamber (12). The striker (14) is disposed in the storage bin chamber (12) and is opposite to the position of the nozzle structure (13). The power mechanism is connected to the striker (14) and is used to drive the striker (14) to move back and forth along its central axis; The sorting module (2) has a liquid inlet channel (22) and a sorting channel (23). The outlet end of the nozzle structure (13) and the liquid inlet channel (22) are both connected to the sorting channel (23); Wherein, the striker (14) cooperates with the nozzle structure (13) to press the materials in the storage bin chamber (12) into lumps (3) one by one and then push them into the sorting channel (23). The lumps (3) flow along with the liquid in the sorting channel (23) and are formed into microspheres; The liquid inlet channel (22) includes a first channel and a second channel. The first channel extends in the same direction as the sorting channel (23), and the cross-section of the first channel is annular. One end of the first channel is connected to the liquid inlet (21), and the other end of the first channel is connected to one end of the second channel. The other end of the second channel is connected to the sorting channel (23); The longitudinal section of the liquid inlet channel (22) is a U-shaped structure with an opening downward, and the sorting channel (23) is connected to the central position of the U-shaped structure; The inner wall shape of the nozzle structure (13) is adapted to the end shape of the striker (14). When the striker (14) is in the initial position, the inner wall (131) of the nozzle structure (13) fits with the striker head (141) of the striker (14) to form a seal, and the sealing method is linear sealing or surface sealing; The nozzle opening (132), the sorting channel (23) and the striker (14) are coaxially arranged.

2. The microsphere preparation device according to claim 1, characterized in that: It further includes at least one feed inlet (11). The feed inlet (11) is provided on the side wall of the ball manufacturing module (1) and is connected to the storage bin chamber (12). The raw materials for microsphere preparation enter the storage bin chamber (12) through the feed inlet (11).

3. The microsphere preparation device according to claim 2, characterized in that: A pressure device is provided at the feed inlet (11). The pressure device is used to provide a positive pressure to push the materials at the feed inlet (11) into the storage bin chamber (12).

4. The microsphere preparation device according to claim 1, characterized in that: It further includes a liquid inlet (21). The liquid inlet (21) is provided on the side wall of the sorting module (2) and is connected to the liquid inlet channel (22).

5. The microsphere preparation device according to claim 1, characterized in that: The longitudinal section of the liquid inlet channel (22) is an M-shaped structure, and the sorting channel (23) is connected to the central position of the M-shaped structure.

6. The microsphere preparation device according to claim 1, characterized in that: The nozzle opening (132) of the nozzle structure (13) is a tapered structure with a wider upper part and a narrower lower part. The taper angle range of the tapered structure is 0 - 60 degrees, and the height dimension range of the nozzle opening (132) is 0.05 mm - 5 mm.

7. The microsphere preparation device according to claim 1, characterized in that: It further includes: A control unit and a liquid delivery unit; The liquid delivery unit is in communication with the liquid inlet channel (22) via a liquid inlet (21), and the power mechanism and the liquid delivery unit are both electrically connected to the control unit, which is used to control the liquid flow rate and the impact frequency and impact amplitude of the striker (14).

8. The microsphere preparation device according to claim 1, characterized in that: It also includes a feeding unit, which is used to continuously transport raw materials for preparing microspheres to the storage chamber (12).

9. The microsphere preparation device according to claim 1, characterized in that: It also includes a microsphere collection and detection unit, which is connected to the outlet of the sorting channel (23) and is used to collect microsphere products and perform detection.

10. The microsphere preparation device according to claim 9, characterized in that: It also includes a pressure filling unit, which is arranged downstream of the microsphere collection and detection unit and is used to fill the microsphere products that have passed the detection.

11. The microsphere preparation device according to claim 9, characterized in that: It also includes a waste liquid recovery unit, which is arranged downstream of the microsphere collection and detection unit and is used to recover waste liquid from microsphere products that fail the test.

12. A method for preparing microspheres using the microsphere preparation device according to claim 1, characterized in that: include: Step S1, continuously delivering the microsphere preparation raw material to the feed port (11) and controlling the pressure of the feed port (11); Step S2, under the action of pressure, the raw materials for preparing microspheres enter and fill the storage chamber (12), and the pressure in the storage chamber (12) is maintained; Step S3, driving the striker (14) to perform up and down reciprocating motion through the power mechanism; When the striker (14) moves upward, the raw material for preparing microspheres in the storage chamber (12) quickly fills the space vacated by the striker head (141) under the action of pressure; when the striker (14) is quickly pressed downward, the raw material for preparing microspheres located at the nozzle opening (132) is pressed into a block (3), and the block (3) is quickly pushed out of the nozzle opening (132), and under the action of inertia, it separates from the nozzle opening (132) and flows into the sorting channel (23); Step S4, at the same time, the liquid in the liquid inlet (21) flows into the sorting channel (23) through the liquid inlet channel (22), and the shear force of the liquid causes the block (3) to separate from the nozzle opening (132); Step S5, the block (3) moves toward the outlet of the sorting channel (23) along with the liquid. During this process, the block (3) gradually changes into a round sphere under the action of surface tension; When the striker (14) moves at a constant frequency, the size of the microspheres is adjusted by adjusting the pressure of the feed port (11); When the pressure of the feed port (11) increases, the sphere becomes larger, and vice versa; When the pressure of the feed port (11) is constant, the ejection volume and ejection frequency of the block (3) are adjusted by adjusting the movement frequency of the striker (14); When the impact frequency of the striker (14) increases, the ejection volume of the block (3) becomes smaller and the ejection frequency becomes faster; conversely, the ejection volume of the block (3) becomes larger and the ejection frequency becomes slower; When the pressure of the feed port (11) and the impact frequency of the striker (14) are constant, the ejection volume of the block (3) is adjusted by adjusting the impact amplitude of the striker (14); When the impact amplitude of the striker (14) increases, the ejection volume of the block (3) increases; conversely, the ejection volume of the block (3) decreases.

13. The method for preparing microspheres according to claim 12, wherein: Also includes: By adjusting the liquid flow rate of the liquid inlet (21), the distance between the blocks (3) is adjusted, thereby adjusting the ball-liquid ratio during microsphere collection.

14. The method for preparing microspheres according to claim 12, wherein: The raw material for preparing the microspheres is a loose substance, which is composed of at least two substances with no or weak bonding, and has high viscosity.

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